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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIF13B-TENM4 (FusionGDB2 ID:42563)

Fusion Gene Summary for KIF13B-TENM4

Fusion gene summary

Fusion gene information	Fusion gene name: KIF13B-TENM4
	Fusion gene ID: 42563
		Hgene	Tgene
	Gene symbol	KIF13B	TENM4
	Gene ID	23303	26011
	Gene name	kinesin family member 13B	teneurin transmembrane protein 4
	Synonyms	GAKIN	Doc4\|ETM5\|ODZ4\|TEN4\|TNM4\|Ten-M4\|ten-4
	Cytomap	8p12	11q14.1
	Type of gene	protein-coding	protein-coding
	Description	kinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKIN	teneurin-4odz, odd Oz/ten-m homolog 4protein Odd Oz/ten-m homolog 4tenascin-M4
	Modification date	20200313	20200313
	UniProtAcc	Q9NQT8	.
	Ensembl transtripts involved in fusion gene	ENST00000524189, ENST00000404075, ENST00000521515,	ENST00000533038, ENST00000278550,
Fusion gene scores	* DoF score	23 X 22 X 14=7084	17 X 17 X 9=2601
	# samples	27	18
	** MAII score	log2(27/7084*10)=-4.71353289970108 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/2601*10)=-3.85299758761332 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KIF13B [Title/Abstract] AND TENM4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIF13B(28980108)-TENM4(78387432), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KIF13B	GO:0050770	regulation of axonogenesis	20194617

Fusion gene breakpoints across KIF13B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TENM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0ES-01A	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-

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Fusion Gene ORF analysis for KIF13B-TENM4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000524189	ENST00000533038	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-
In-frame	ENST00000524189	ENST00000278550	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-
intron-3CDS	ENST00000404075	ENST00000278550	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-
intron-3CDS	ENST00000521515	ENST00000278550	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-
intron-intron	ENST00000404075	ENST00000533038	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-
intron-intron	ENST00000521515	ENST00000533038	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000524189

KIF13B

chr8

28980108

ENST00000278550

TENM4

chr11

78387432

11851

3574

6623

2194

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000524189	ENST00000278550	KIF13B	chr8	28980108	-	TENM4	chr11	78387432	-	0.000788054	0.9992119

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Fusion Genomic Features for KIF13B-TENM4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIF13B-TENM4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:28980108/chr11:78387432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIF13B Q9NQT8	.
FUNCTION: Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. {ECO:0000269\|PubMed:20194617}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

1096_1143

1178

1827.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

364_439

1178

1827.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

607_710

1178

1827.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

752_772

1178

1827.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

471_535

1178

1827.0

Domain

Note=FHA

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

5_353

1178

1827.0

Domain

Kinesin motor

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

103_110

1178

1827.0

Nucleotide binding

ATP

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1887_1906

1753

2770.0

Repeat

Note=YD 5

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1928_1946

1753

2770.0

Repeat

Note=YD 6

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1947_1967

1753

2770.0

Repeat

Note=YD 7

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1974_1991

1753

2770.0

Repeat

Note=YD 8

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1992_2013

1753

2770.0

Repeat

Note=YD 9

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2014_2031

1753

2770.0

Repeat

Note=YD 10

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2034_2054

1753

2770.0

Repeat

Note=YD 11

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2057_2077

1753

2770.0

Repeat

Note=YD 12

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2085_2104

1753

2770.0

Repeat

Note=YD 13

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2110_2127

1753

2770.0

Repeat

Note=YD 14

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2128_2154

1753

2770.0

Repeat

Note=YD 15

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2156_2169

1753

2770.0

Repeat

Note=YD 16

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2170_2193

1753

2770.0

Repeat

Note=YD 17

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2196_2216

1753

2770.0

Repeat

Note=YD 18

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2217_2237

1753

2770.0

Repeat

Note=YD 19

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2239_2259

1753

2770.0

Repeat

Note=YD 20

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2271_2291

1753

2770.0

Repeat

Note=YD 21

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2293_2313

1753

2770.0

Repeat

Note=YD 22

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

2339_2380

1753

2770.0

Repeat

Note=YD 23

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIF13B

chr8:28980108

chr11:78387432

ENST00000524189

1721_1763

1178

1827.0

Domain

CAP-Gly

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

179_182

1753

2770.0

Compositional bias

Note=Poly-Pro

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1_341

1753

2770.0

Domain

Teneurin N-terminal

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

562_593

1753

2770.0

Domain

EGF-like 1

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

594_624

1753

2770.0

Domain

EGF-like 2

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

626_658

1753

2770.0

Domain

EGF-like 3

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

659_690

1753

2770.0

Domain

EGF-like 4

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

692_725

1753

2770.0

Domain

EGF-like 5

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

726_757

1753

2770.0

Domain

EGF-like 6

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

758_787

1753

2770.0

Domain

EGF-like 7

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

788_831

1753

2770.0

Domain

EGF-like 8

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1216_1259

1753

2770.0

Repeat

Note=NHL 1

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1264_1308

1753

2770.0

Repeat

Note=NHL 2

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1334_1378

1753

2770.0

Repeat

Note=NHL 3

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1393_1444

1753

2770.0

Repeat

Note=NHL 4

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1523_1566

1753

2770.0

Repeat

Note=NHL 5

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1576_1595

1753

2770.0

Repeat

Note=YD 1

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1612_1632

1753

2770.0

Repeat

Note=YD 2

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1675_1694

1753

2770.0

Repeat

Note=YD 3

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1695_1717

1753

2770.0

Repeat

Note=YD 4

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

1_345

1753

2770.0

Topological domain

Cytoplasmic

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

367_2769

1753

2770.0

Topological domain

Extracellular

Tgene

TENM4

chr8:28980108

chr11:78387432

ENST00000278550

346_366

1753

2770.0

Transmembrane

Helical

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Fusion Gene Sequence for KIF13B-TENM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42563_42563_1_KIF13B-TENM4_KIF13B_chr8_28980108_ENST00000524189_TENM4_chr11_78387432_ENST00000278550_length(transcript)=11851nt_BP=3574nt
GGCAGACGGAAGCCGAACGAGTTCCTCGGCGGCTGCAGGATGGGGGACTCCAAAGTGAAAGTGGCGGTGCGGATACGACCCATGAACCGG
CGAGAGACTGACTTGCATACCAAATGTGTGGTGGATGTGGATGCAAACAAGGTTATTCTTAATCCTGTAAATACGAATCTTTCCAAAGGA
GATGCCCGGGGCCAGCCGAAGGTGTTTGCTTATGATCATTGTTTCTGGTCTATGGATGAATCTGTCAAAGAAAAGTATGCAGGTCAAGAT
ATTGTTTTCAAGTGCCTTGGAGAGAATATCCTGCAGAATGCTTTTGATGGCTACAATGCATGTATCTTTGCCTATGGACAGACTGGCTCT
GGAAAATCTTATACCATGATGGGCACAGCTGACCAACCTGGATTAATCCCAAGACTTTGCAGTGGACTCTTTGAACGAACTCAGAAAGAG
GAAAATGAAGAACAGAGTTTTAAAGTAGAAGTGTCCTACATGGAAATTTATAATGAAAAAGTTCGAGACCTTCTTGATCCCAAAGGAAGC
CGTCAGACGTTGAAAGTCAGAGAGCATAGTGTGTTGGGACCTTATGTCGACGGACTTTCTAAACTGGCTGTCACAAGCTACAAGGATATT
GAGTCGTTGATGTCTGAGGGTAACAAATCTCGCACAGTTGCTGCAACCAACATGAACGAGGAGAGTAGCCGATCCCATGCAGTTTTCAAA
ATCACCCTCACACATACTCTCTACGATGTGAAGTCTGGGACATCTGGAGAGAAAGTGGGCAAACTCAGCCTGGTGGATTTAGCTGGCAGT
GAACGAGCAACGAAGACAGGCGCTGCAGGGGACAGGCTGAAGGAAGGGAGCAACATTAACAAGTCCCTCACAACCCTCGGTCTGGTTATC
TCAGCTCTTGCAGATCAGAGTGCTGGCAAAAACAAGAATAAATTTGTTCCATATCGTGACTCAGTTCTCACTTGGCTGCTCAAAGACAGC
CTCGGGGGTAACAGCAAGACCGCCATGGTGGCTACTGTGAGTCCTGCAGCTGATAACTATGATGAAACCCTCTCAACTCTGCGGTATGCA
GATCGAGCCAAGCACATTGTAAACCACGCTGTGGTGAATGAGGACCCTAATGCCCGAATTATCCGGGATCTCCGGGAAGAAGTTGAGAAA
CTCCGGGAGCAGCTGACCAAAGCAGAGGCAATGAAATCTCCAGAGCTAAAGGACCGGCTGGAAGAATCTGAGAAGCTAATCCAGGAAATG
ACTGTGACCTGGGAGGAGAAATTAAGGAAAACGGAGGAGATTGCACAGGAACGACAGAAACAGCTTGAGAGTCTTGGAATATCTCTTCAG
TCTTCGGGAATCAAAGTTGGGGATGATAAATGCTTCCTTGTGAATCTGAATGCTGACCCAGCTCTGAATGAGCTTCTGGTGTACTATTTA
AAGGAACATACATTGATAGGGTCAGCAAATTCCCAAGATATCCAACTGTGCGGCATGGGAATTCTTCCTGAACACTGTATTATAGACATC
ACGTCAGAAGGCCAGGTTATGCTGACTCCTCAGAAGAACACCAGAACATTTGTAAATGGGTCATCTGTCTCCAGTCCAATACAGCTACAC
CATGGGGACAGGATATTATGGGGAAACAATCATTTCTTCAGACTCAATTTGCCTAAAAAGAAAAAGAAAGCAGAACGAGAGGATGAGGAC
CAGGATCCCTCCATGAAGAACGAGAATAGTTCTGAGCAGCTGGATGTAGACGGAGACTCCTCCAGCGAGGTGTCCAGTGAAGTTAACTTT
AATTACGAATACGCACAGATGGAGGTCACCATGAAGGCCCTGGGCAGCAATGATCCGATGCAGTCCATATTAAACAGCTTAGAACAACAG
CATGAAGAAGAAAAACGATCTGCACTGGAGCGCCAGAGGCTTATGTATGAGCACGAATTGGAGCAGCTCCGGAGAAGGCTGTCTCCTGAG
AAGCAGAACTGCCGGAGCATGGACAGGTTTTCTTTCCACTCGCCCAGCGCTCAGCAACGCTTAAGACAGTGGGCTGAGGAGAGAGAAGCA
ACGTTGAATAACAGCCTGATGAGGCTGAGGGAACAAATTGTTAAGGCCAATCTATTGGTGAGAGAAGCTAATTACATTGCTGAGGAGCTG
GATAAAAGAACAGAATACAAAGTTACCCTACAGATTCCAGCCTCCAGCCTGGATGCCAACAGGAAGCGAGGCTCTCTTCTTAGTGAGCCT
GCAATCCAGGTGAGAAGAAAAGGAAAAGGAAAGCAGATTTGGTCTTTGGAAAAACTGGACAACAGGCTGTTGGATATGAGAGACCTTTAT
CAGGAGTGGAAAGAGTGTGAAGAAGATAACCCAGTAATACGATCATACTTCAAACGTGCTGATCCATTCTATGATGAGCAGGAAAATCAC
AGTCTCATTGGGGTGGCCAATGTCTTCCTCGAGTCACTTTTCTATGATGTGAAGTTACAATACGCTGTTCCCATCATCAACCAGAAAGGA
GAGGTGGCAGGTCGGCTGCACGTGGAGGTGATGCGACTCAGTGGTGATGTTGGGGAGAGGATCGCAGGAGGCGATGAGGTGGCAGAGGTC
TCCTTTGAGAAGGAGACCCAGGAGAACAAACTGGTGTGCATGGTTAAAATCCTGCAAGCTACTGGGTTGCCACAGCATCTGTCCCACTTT
GTGTTCTGCAAATACAGCTTCTGGGATCAACAGGAGCCGGTGATTGTCGCTCCTGAAGTGGACACCTCCTCCTCTTCCGTCAGCAAGGAG
CCGCACTGCATGGTTGTCTTTGATCATTGCAATGAGTTTTCTGTTAACATCACCGAAGACTTTATCGAGCATCTTTCCGAAGGAGCATTG
GCAATTGAAGTATATGGACATAAAATAAACGATCCCCGGAAAAACCCCGCCCTGTGGGATTTGGGAATCATCCAAGCAAAGACACGTAGT
CTTCGGGACAGATGGAGTGAAGTGACCAGGAAATTGGAATTCTGGGTTCAAATCTTGGAACAGAATGAGAATGGTGAATACTGCCCTGTA
GAAGTGATTTCTGCAAAGGATGTCCCAACAGGAGGAATCTTCCAGCTCCGGCAGGGGCAGTCCCGGAGAGTTCAAGTCGAAGTGAAGTCA
GTGCAGGAATCTGGGACTTTACCACTGATGGAAGAATGTATACTGTCTGTTGGCATTGGATGTGTCAAAGTTAGACCGCTCAGAGCCCCC
AGAACACATGAGACCTTCCATGAGGAAGAGGAAGACATGGACAGCTACCAGGATCGAGATTTAGAGAGACTTCGTAGAAAATGGCTAAAT
GCATTAACAAAACGTCAGGAGTACTTGGATCAACAATTGCAAAAGCTTGTCAGTAAACGTGATAAAACAGAGGATGATGCTGACCGTGAA
GCGCAGCTTCTGGAGATGCGGTTGACCCTAACTGAGGAGAGGAACGCGGTGATGGTCCCCTCTGCTGGCAGTGGTATTCCAGGGGCCCCA
GCAGAATGGACCCCAGTACCTGGGATGGAGACACACATTCCTGTTATATTCCTGGACTTAAATGACCAAGTCCGGAACAGCTACTACATC
GGGGCCGATGGCTCCTTGCGGCTGCTGCTGGCCAACGGCATGGAGGTGGCGCTGCAGACTGAGCCCCACTTGCTGGCTGGCACCGTCAAC
CCCACCGTGGGCAAGAGGAATGTCACGCTGCCCATCGACAACGGCCTCAACCTGGTGGAGTGGCGCCAGCGCAAAGAGCAGGCTCGGGGC
CAGGTCACTGTCTTTGGGCGCCGGCTGCGGGTTCACAACCGAAATCTCCTATCTCTGGACTTTGATCGCGTAACACGCACAGAGAAGATC
TATGATGACCACCGCAAGTTCACCCTTCGGATTCTGTACGACCAGGCGGGGCGGCCCAGCCTCTGGTCACCCAGCAGCAGGCTGAATGGT
GTCAACGTGACATACTCCCCTGGGGGTTACATTGCTGGCATCCAGAGGGGCATCATGTCTGAAAGAATGGAATACGACCAGGCGGGCCGC
ATCACATCCAGGATCTTCGCTGATGGGAAGACATGGAGCTACACATACTTAGAGAAGTCCATGGTGCTGCTACTACACAGCCAGAGGCAG
TATATCTTTGAGTTCGACAAGAATGACCGCCTCTCTTCTGTGACGATGCCCAACGTGGCGCGGCAGACACTAGAGACCATCCGCTCAGTG
GGCTACTACAGAAACATCTATCAGCCCCCTGAGGGCAATGCCTCAGTCATACAGGACTTCACTGAGGATGGGCACCTCCTTCACACCTTC
TACCTGGGCACTGGCCGCAGGGTGATATACAAGTATGGCAAACTGTCAAAGCTGGCAGAGACGCTCTATGACACCACCAAGGTCAGTTTC
ACCTATGACGAGACGGCAGGCATGCTGAAGACCATCAACCTACAGAATGAGGGCTTCACCTGCACCATCCGCTACCGTCAGATTGGGCCC
CTGATTGACCGACAGATCTTCCGCTTCACTGAGGAAGGCATGGTCAACGCCCGTTTTGACTACAACTATGACAACAGCTTCCGGGTGACC
AGCATGCAGGCTGTGATCAACGAGACCCCACTGCCCATTGATCTCTATCGCTATGATGATGTGTCAGGCAAGACAGAGCAGTTTGGGAAG
TTTGGTGTCATTTACTATGACATTAACCAGATCATCACCACAGCTGTCATGACCCACACCAAGCATTTTGATGCATATGGCAGGATGAAG
GAAGTGCAGTATGAGATCTTCCGCTCGCTCATGTACTGGATGACCGTCCAGTATGATAACATGGGGCGAGTAGTGAAGAAGGAGCTGAAG
GTAGGACCCTACGCCAATACCACTCGCTACTCCTATGAGTATGATGCTGACGGCCAGCTGCAGACAGTCTCCATCAATGACAAGCCACTC
TGGCGCTACAGCTACGACCTCAATGGGAACCTGCACTTACTGAGCCCTGGGAACAGTGCACGGCTCACACCACTACGGTATGACATCCGC
GACCGCATCACTCGGCTGGGTGACGTGCAATACAAGATGGATGAGGATGGCTTCCTGAGGCAGCGGGGCGGTGATATCTTTGAGTACAAC
TCAGCTGGCCTGCTCATCAAGGCCTACAACCGGGCTGGCAGCTGGAGTGTCAGGTACCGCTACGATGGCCTGGGGCGGCGCGTGTCCAGC
AAGAGCAGCCACAGCCACCACCTGCAGTTCTTCTATGCAGACCTGACCAACCCCACCAAGGTCACCCACCTGTACAACCACTCCAGCTCT
GAGATCACCTCCCTCTACTACGACTTGCAAGGACACCTCTTTGCCATGGAGCTGAGCAGTGGTGATGAGTTTTACATAGCTTGTGACAAC
ATCGGGACCCCTCTTGCTGTCTTTAGTGGAACAGGTTTGATGATCAAGCAAATCCTGTACACAGCCTATGGGGAGATCTACATGGATACC
AACCCCAACTTTCAGATCATCATAGGCTACCATGGTGGCCTCTATGATCCACTCACCAAGCTTGTCCACATGGGCCGGCGAGATTATGAT
GTGCTGGCCGGACGCTGGACTAGCCCAGACCACGAGCTGTGGAAGCACCTTAGTAGCAGCAACGTCATGCCTTTTAATCTCTATATGTTC
AAAAACAACAACCCCATCAGCAACTCCCAGGACATCAAGTGCTTCATGACAGATGTTAACAGCTGGCTGCTCACCTTTGGATTCCAGCTA
CACAACGTGATCCCTGGTTATCCCAAACCAGACATGGATGCCATGGAACCCTCCTACGAGCTCATCCACACACAGATGAAAACGCAGGAG
TGGGACAACAGCAAGTCTATCCTCGGGGTACAGTGTGAAGTACAGAAGCAGCTCAAGGCCTTTGTCACCTTAGAACGGTTTGACCAGCTC
TATGGCTCCACAATCACCAGCTGCCAGCAGGCTCCAAAGACCAAGAAGTTTGCATCCAGCGGCTCAGTCTTTGGCAAGGGGGTCAAGTTT
GCCTTGAAGGATGGCCGAGTGACCACAGACATCATCAGTGTGGCCAATGAGGATGGGCGAAGGGTTGCTGCCATCTTGAACCATGCCCAC
TACCTAGAGAACCTGCACTTCACCATTGATGGGGTGGATACCCATTACTTTGTGAAACCAGGACCTTCAGAAGGTGACCTGGCCATCCTG
GGCCTCAGTGGGGGGCGGCGAACCCTGGAGAATGGGGTCAACGTCACTGTGTCCCAGATCAACACAGTACTTAATGGCAGGACTAGACGC
TACACAGACATCCAGCTCCAGTACGGGGCACTGTGCTTGAACACACGCTACGGGACAACGTTGGATGAGGAGAAGGCACGGGTCCTGGAG
CTGGCCCGGCAGAGAGCCGTGCGCCAAGCGTGGGCCCGCGAGCAGCAGAGACTGCGGGAAGGGGAGGAAGGCCTGCGGGCCTGGACAGAG
GGGGAGAAGCAGCAGGTGCTGAGCACAGGGCGGGTGCAAGGCTACGACGGCTTTTTCGTGATCTCTGTCGAGCAGTACCCAGAACTGTCA
GACAGCGCCAACAACATCCACTTCATGAGACAGAGCGAGATGGGCCGGAGGTGACAGAGAGGACCAAGGACTTCTTGCCAAAGACAGCTA
CTCTTTTGTGGCCGCATACCTGACTGTGTTGTACTTTTAAAAAAATGATTTTTTAACAAGTGCAGAAACAAAAAGATACTGGTTGCATTG
TAACTCATGCAACATCCTTTTTTTTAGAAAAGAAAAACACAGATTTGGCCTTCGCACATTTTTTGCAAAGAACAGAAGGTATTTTTTTCT
GTAGTGTGATCACAATGAAAACTTTATTGTCTTTTGTTCCCTTTTTCCTTGAGGATTTTTCCCTTGTCGTTTGGGGTATGTATCTCCTCT
CTGAGATGCATCTCCTGGGGTGTGTCCTCGTCTGTCCCTAGGTACCCAGTGTGATGTGGGACATGAATGTCTGTGCTAACTTGTCTCATG
TGCAACCCTTTCTTCTTCGACTGGGGTCGGGCAGGAGTAAAGGGAGTGATGGGCCAGTACAACACCCCTTCCAAGGGGGCCTGGGAGGAG
GGTCTGTAGGACCTGAGGCTCCTTGGCAGGGCTCCTGCAGAAGAGTGGTGGATTTCTTCTCACCTTGTTCTCTGCCTCCAGAGGATCATA
GATGGCTTCATCTTGCTCCAGGGAATTTCATGGTGTTGTTCAGCACCTTTTTTAAGCTGCCCCAAACTCCTGTTCAAGCTTTCTATTTTG
ATGCTGAATGAAACCCCCTACCACTTTTGCAAATCCTGTGTAGTTGTCGGTGCCACCCCCATGCTGGGATAGAGAAAGTGTCTCCCAGGT
CCTTTCCCCCAGACCAGTGACATAACATCCTGGGCTCAGAGTCCCATCCTCCCGGGAGGGAAAGCACCCAGGATGCCTGTGATTGGTTGG
TCCTCCATGATGTTCCTGTTCATCTCCTCCTTTCTCCCAAAGCCAGATGTGAGAACGAGCACTGCACAGCAAGCCTTCAATGTGGGCACC
ATGTCCACAGAACAGAAGGCCACCCATGGCAAAGGCATGGCAGTGGTGGCGAGGGCACCAGCCTGCCTTCCGAGGCAAAGCCCTCTCTCT
ATGACTTTGAGTATCTTCCCTCCACCACTCAGCCGCCACCACTGAGACGTAGGAATGTGGAGGGAGGTGCTTGGTGGCCTTTGATTCTGG
AAAAATGCTTAACAAAAAAAGCCAGCCAAAGAGAGGAAGGCATAAGCTAAGCATCCTTCTAACCAGTTCCCAAAGTCCCATCTGCCTCCA
TGTACCAGCTGATCGCAGAGCTGGACTGGGGCAGGCTGGGCTTCCAGGAAATTCCTGAAGTTCTGAAACAGCTTCCCCTCTAGAGAAGCC
CACCCAATGTGTTTTTTAGTGACAGGAAGAAAGGAGGGAAGAGCTGATGTGGTGTGGCCTGCCCATATCATACAACCCCACCAGGAGCAG
GGCAGTTCCCAAGGTGGGTGCCCGTAGATCTGGGAGGCCAGGCTGGCATGATTCCTGTGAAGAACTGTGCCTGTGTCGTCAGGGAGAGGC
CTGAGCCCTCTCAGAAGCAGGGACAGCCCACACCTGAAGAGCACGCCCAAGCTGAGGCAGCAGCCAGCAGGCTGGGGGAGCAGTGAGGGC
AGGGGGAGTCACAGCCAGAGCTGGGAGCCCCTTGTTCAAGGATTCCATTCCTGGTTCATCCGCCTAATTACCATTGTCATTACCACTCAC
AGGAGGCTCTGGGAGATGGGAGGGGAAGCCAAATGCTTCCTTTTAAGCTGGGCTTCTTAGAAAATGGAACTTTTATGGGTTACATTTACA
TTAAGTGTGGAAAATGAATTCTGAGTCTGAGCTATTCCCCGTGGAAACCTTGTTGGACTGATAAGCTCATGGCACCTCTATAGCCTTACT
CACATAGTCTTCAGAATATTACACAAGTTAATGAAACTGAGAAGGTCTGACTGCATGAGGATCGGAGCAGCATGTAGTCTGGGTTCTGCC
TGGCAGAGGGAGGCAACCAAAACTTCTTGGGGAGAGGAGATTTCGCCTTAACGTCATCCCACTGGGATTAGAGGATGTGTTTCGCTAAGT
GCTCTTCCTGTTTCCAAAAAAAAAGCCACCCTGCTGCAGCAGTGCGCTTTGGCCTGCTTGTCCACTGGTTGCCCATTGCCCCTGGATCCA
GAGCTCTACTGAGTCAGATACAGTGCTCTGCAGGCCTGCTGTGGGAGGCATGAGCTGGAGATGGGGGCTCCCATCTGGCAGGATCATTCT
TGGATGAGATGGAAAACAGTTTGGCCTGAAGAACACAAGTTTTGTCCTCCAGAAGGGACTTACGCCTCTCAAAATGTACTCTTCATACCA
AGGGCCCTTGGGCAAAGTGCTCCTGCCCAGTTGATCAGTCCCATCCTGGCTGCCTGACATCAGTGAAGACCTGCTGGGGATGTCTGCTCA
GAGGTCAGGAACGGCATGCGGTCCACAGGAACCAGCTCCCTACGCTTCCCCCACGCCCTGTCCCTCCTCCACAGCCCCCTCCCCAAAGGA
ATAGGGTGGACTTTTAGGGATCAAAAACAGAATTATTGGGTGTTTCATTTATTTTTTTCTTTCTTTCTTTTTTTTTTCATAGAGATGGGG
TCTCACTATGTTGCCCAGGCTGTTCTCAAACTCCTGGCCTCAGGCGATCCACCTTGGCCTCCTGAAGTGCTGGGGTTACAGGTGTGAGCC
ACTGCGCCTGGACTGAGTGTTTGTTTCTTTAAAGGATCTTATATTTTTCCTGTGCTACATACCACCACAGCAGCCCAGCTTCTGTGGGGA
GAGAAGTTGAAGGATCCCGAAGCTTTAGAAAAAGGATCTCAGCTGTGGCACAGGCAGTGTTATGCGCCTCACTGCCACATTGGTGCTGTT
GTATTGAAGGTGGTGCTTCTGGCCTTGGCCCTTTTGAGTTGGTTTCCATTTGGGCTGCAGGTGACTCAGTGACTCCCTCCTCAAGCTGTC
CTCCTGCTAAGACCAGCAGTCACAAACCCATGGCAAGGGTGAGTGTGAAGGCCTAACCCTGTGCCTATGTAATAGGCTCCAAGCATCGAC
TCCCATCCTGAGAGGACCGGCCCTTTTGACACTCACCAACCAAATCTGTTCATTCGATAGAGTGACCAGGCCTCCCTCACCTGCCCAGGT
GTATGATCCTACAGTTCCTGCCTTCTCTCCTACCCCGCACAGCTGCCAACTGGTCCTACATCCTCAGCCCCTCTGCCACCACCTTAAATA
GGACTTTACTGATTCCCCAACTTTGTTTTTTTGTAGGATGAGATTTCCTTTTTATCCCACCCCCCCACACCCCAAACAGACATTGCTGGA
GGGCAGACTGGAGGAAGGGGAAGGCATGCAGGTAAATTACTGCCTTGTCAGCCTCTGACCCTCATCTCTCAGAATTGTTGGCTGAGAATT
AACCCAAGGACCACACCAGTGCCTGATTTCTACTTAGGGAGAGAGGATTGGAAACGATCCCTAAGAAACTGACTGAGGGTGAGAATGGCC
AGGAGGTGTGTGTCCAAATAACCAGGAGGGGGCACAGAAGATGATGGCAAGGCAGACTGGGCAGTGTTTTGTAGACACAGAACAAAGAAT
CAGAATTTGAAAAAAGAAGAAAAACAAATCTTCGCAGCTGCAACTTTAAAGTATCACCTTTATAGATGGCAGGGATTTCCATTATGCAAA
TGGAATCTAAGATTTCAATGTGAAATCTTAGAATGCAGTTTTACCACTTGCAGTCTTGTATTTGTGGTGGCCATGTGGTGAGGGCGGTGA
TGCTGAGCTTTCTGCCCAGGAGGAATGAGCTTTCAAGCTCTCAGCAGGGTGTCAGGCTTGGGGATTTGAGCATCCACTGCTCAAAGTCCA
GGCTATTCTCCAGTCCTCACGGCAGCCACTAAGCCCAGGAGCCAGACCTGGCCCGGGGACACATCTCCTGAGGGATCCCAGAAAGAACCC
AGTCTTTCCTTTCCCTTGGGGTCCTTGTTAGAATGAAAACCTCTCTATTTAAGGCACATCATTCCCAGCTAGGTTTATACACTTGTCTAT
ATTTTACTGGAGGAAAGGGAATTAAAAAAGAACTCTGCAGTTCAAGGCCCTTTCATTTAACCTTCCAAAAACAGCAAACTCATTTTAAAG
ACTCATTGCTGAGGTGATAGAGAGAAACCTTATCCTCTCCAACCTTCACATTCACAAAAACCATCCTTGTGTACTTGACTGCCCTAGACA
GTGGTGACTCTTAGGTTTCATTACGAATGTGGAATATCAGAGTGTGGGAAGGCCCAGGCGAGGGCCAATGTTGTGTTTCTTACCCCCTCT
GGAATGCCAAAGGCAAGGTACTAGGTGACCTCCTGGTCCCCAAGAAAATGTGATTTATTCTGAGGGCGAACAGCCAAGGGAGGACTAGTC
TGGAGCACGCTCGGCCGTCCTGGCAGGAGCTGAGCCTCAGGTGTCTGGCGGTGCCCCAGCAGCCCTGGATTCACCCAACACCAGAATCCC
ACTTTTCTAAATCCACCTGTTGTTCTGAGCACCTCTGAACCCGCAGCTTCGGCAAAAGGAGTCTGTACCAAGCTGCTTCTGGATGACCAA
CACTGGAGACTCTGGCCTTACCATGTGGAAATCATTTTCCTGAAGTCTGGAACTAATTTTGAGAAGTTTTTTTCTCAACACTTTTGTGTT
TCTAACACTGTATCTTGACTGTGTAAATACCAACAAGGCTGTAAATAAATGCAGATGTAGATACCTTCTAGAAAAAAAAAAGCATAAAAA
CAAAACCAGAAGTGATCCCGTGTAGCCTTCGTTGACAAATAAAGACTATTTTGTGTTTACAGGTGTCTGGTGGCCTTTGCTTGGAGATAA
AGGCTTCCTCTTGCCTGTCCCAGCCCCCGAGCCATCCTGGGTTTGCACTTCCCTGCTGGCTGCTATCAGGATGACCTGGGAGAGGACTCA
GTCCTAGGCCCCAGGGTCCCTCTAAATCCCTCCAGGCTGCAGCTCTGTCAAGAGGGATGTCCAGAGGGTCTCTAAGACCCTGAAGCTTGA
CTTTGCAATTGCATGACAGGAATAAATATCACAGCTCCTCTGACATCACTAGTGCAGCGTGGCTCCCCATCCCACTGCTGCCCTCGTTCA
GGGACAGGCTGAAGGGGCCAACGAACCCAACCCTCCCAGAGGAGGGAGCCTTGCTCCACCACTGGGCACACAGAGTCATCCACCATGCCA

>42563_42563_1_KIF13B-TENM4_KIF13B_chr8_28980108_ENST00000524189_TENM4_chr11_78387432_ENST00000278550_length(amino acids)=2194AA_BP=1178
MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQN
AFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLG
PYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRL
KEGSNINKSLTTLGLVISALADQSAGKNKNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVN
EDPNARIIRDLREEVEKLREQLTKAEAMKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDDKCFL
VNLNADPALNELLVYYLKEHTLIGSANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFF
RLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRSALERQR
LMYEHELEQLRRRLSPEKQNCRSMDRFSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREANYIAEELDKRTEYKVTLQIP
ASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDLYQEWKECEEDNPVIRSYFKRADPFYDEQENHSLIGVANVFLESL
FYDVKLQYAVPIINQKGEVAGRLHVEVMRLSGDVGERIAGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHLSHFVFCKYSFWDQQEP
VIVAPEVDTSSSSVSKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLE
FWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRPLRAPRTHETFHEEEEDM
DSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKRDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMETHI
PVIFLDLNDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHN
RNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWS
YTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYG
KLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPI
DLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYE
YDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAG
SWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGL
MIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIK
CFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPK
TKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGV
NVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIF13B-TENM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIF13B-TENM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KIF13B-TENM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source