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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF21B-ANP32B (FusionGDB2 ID:42644)

Fusion Gene Summary for KIF21B-ANP32B

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF21B-ANP32B
Fusion gene ID: 42644
HgeneTgene
Gene symbol

KIF21B

ANP32B

Gene ID

23046

10541

Gene namekinesin family member 21Bacidic nuclear phosphoprotein 32 family member B
Synonyms-APRIL|PHAPI2|SSP29
Cytomap

1q32.1

9q22.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF21Bacidic leucine-rich nuclear phosphoprotein 32 family member Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member Bacidic protein rich in leucinesputative HLA-DR-associated protein I-2silver-stainable protein SSP29
Modification date2020031320200313
UniProtAcc

O75037

Q92688

Ensembl transtripts involved in fusion geneENST00000332129, ENST00000360529, 
ENST00000422435, ENST00000461742, 
ENST00000473205, ENST00000339399, 
Fusion gene scores* DoF score3 X 2 X 2=1219 X 20 X 7=2660
# samples 321
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(21/2660*10)=-3.66296501272243
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF21B [Title/Abstract] AND ANP32B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF21B(200992471)-ANP32B(100756913), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANP32B

GO:0006334

nucleosome assembly

20538007

TgeneANP32B

GO:0045596

negative regulation of cell differentiation

22705300


check buttonFusion gene breakpoints across KIF21B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANP32B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-8163-01AKIF21Bchr1

200992471

-ANP32Bchr9

100756913

+


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Fusion Gene ORF analysis for KIF21B-ANP32B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000332129ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000360529ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000422435ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
5CDS-3UTRENST00000461742ENST00000473205KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000332129ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000360529ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000422435ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+
In-frameENST00000461742ENST00000339399KIF21Bchr1

200992471

-ANP32Bchr9

100756913

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332129KIF21Bchr1200992471-ENST00000339399ANP32Bchr9100756913+15723582501059269
ENST00000360529KIF21Bchr1200992471-ENST00000339399ANP32Bchr9100756913+12806642767241
ENST00000461742KIF21Bchr1200992471-ENST00000339399ANP32Bchr9100756913+12806642767241
ENST00000422435KIF21Bchr1200992471-ENST00000339399ANP32Bchr9100756913+15723582501059269

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332129ENST00000339399KIF21Bchr1200992471-ANP32Bchr9100756913+7.51E-050.9999249
ENST00000360529ENST00000339399KIF21Bchr1200992471-ANP32Bchr9100756913+0.0001409660.999859
ENST00000461742ENST00000339399KIF21Bchr1200992471-ANP32Bchr9100756913+0.0001409660.999859
ENST00000422435ENST00000339399KIF21Bchr1200992471-ANP32Bchr9100756913+7.51E-050.9999249

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Fusion Genomic Features for KIF21B-ANP32B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIF21Bchr1200992470-ANP32Bchr9100756912+2.67E-111
KIF21Bchr1200992470-ANP32Bchr9100756912+2.67E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KIF21B-ANP32B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:200992471/chr9:100756913)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF21B

O75037

ANP32B

Q92688

FUNCTION: Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface. {ECO:0000250|UniProtKB:Q9QXL1}.FUNCTION: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:20015864, PubMed:18039846). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:20538007, PubMed:18039846). Plays also an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9EST5, ECO:0000269|PubMed:17178712, ECO:0000269|PubMed:18039846, ECO:0000269|PubMed:20015864, ECO:0000269|PubMed:20538007}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A and B viral genome replication (PubMed:33045004, PubMed:31217244). Plays also a role in foamy virus mRNA export from the nucleus to the cytoplasm (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:31217244, ECO:0000269|PubMed:33045004}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANP32Bchr1:200992471chr9:100756913ENST0000033939907146_25118252.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneANP32Bchr1:200992471chr9:100756913ENST0000033939907123_16118252.0DomainNote=LRRCT
TgeneANP32Bchr1:200992471chr9:100756913ENST0000033939907239_24218252.0MotifNuclear localization signal
TgeneANP32Bchr1:200992471chr9:100756913ENST000003393990716_4018252.0RepeatLRR 1
TgeneANP32Bchr1:200992471chr9:100756913ENST000003393990743_6418252.0RepeatLRR 2
TgeneANP32Bchr1:200992471chr9:100756913ENST000003393990765_8418252.0RepeatLRR 3
TgeneANP32Bchr1:200992471chr9:100756913ENST000003393990789_11018252.0RepeatLRR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134376_604131625.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134631_824131625.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134928_1016131625.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134376_604131611.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134631_824131611.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134928_1016131611.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135376_604131638.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135631_824131638.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135928_1016131638.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135376_604131624.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135631_824131624.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135928_1016131624.0Coiled coilOntology_term=ECO:0000255
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1348_370131625.0DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1348_370131611.0DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1358_370131638.0DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1358_370131624.0DomainKinesin motor
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-13487_94131625.0Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-13487_94131611.0Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-13587_94131638.0Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-13587_94131624.0Nucleotide bindingATP
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341306_1343131625.0RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341346_1384131625.0RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341410_1448131625.0RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341451_1493131625.0RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341502_1539131625.0RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341543_1582131625.0RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-1341585_1622131625.0RepeatNote=WD 7
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341306_1343131611.0RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341346_1384131611.0RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341410_1448131611.0RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341451_1493131611.0RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341502_1539131611.0RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341543_1582131611.0RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-1341585_1622131611.0RepeatNote=WD 7
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351306_1343131638.0RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351346_1384131638.0RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351410_1448131638.0RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351451_1493131638.0RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351502_1539131638.0RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351543_1582131638.0RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-1351585_1622131638.0RepeatNote=WD 7
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351306_1343131624.0RepeatNote=WD 1
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351346_1384131624.0RepeatNote=WD 2
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351410_1448131624.0RepeatNote=WD 3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351451_1493131624.0RepeatNote=WD 4
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351502_1539131624.0RepeatNote=WD 5
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351543_1582131624.0RepeatNote=WD 6
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-1351585_1622131624.0RepeatNote=WD 7


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Fusion Gene Sequence for KIF21B-ANP32B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42644_42644_1_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000332129_ANP32B_chr9_100756913_ENST00000339399_length(transcript)=1572nt_BP=358nt
GGGAGGTGGCTGCCGGGTGGGAGGTGTGTGCGCGTGTGCCGCGCCGTAGGGAGCGGCGGGTCGCGCCGCCGGCTGTCAGCTAGCTCCGCG
CCGCCGCCCGATGGCGCGAGGAGGCGCGCGGGCCCAGCCCCGGGGGGCCGGCCGCGGGTGAGCCCCTCGGCCTGCCGCCCGCGAGCATGT
CACCTCCAGCCGCCGCCGCCGCAGCCTCCGCCAGCCGCGCCCGCGCCCCCGCCTCCCGCAGCCGCAGCCGCTGCCTCGGGCATTGGCCCC
CAGACCCCCGCCTCTGATCCACGCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGT
TCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTT
AATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGG
TCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTT
GAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCT
GCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGA
GGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGA
TGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGA
AGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGA
AACAGAACTGTTCAGTATTGGTTGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGA
CACCCACCCACCCAAAGAGCCAAAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTT
GTGGACTTCACCCCAACAAAATTGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAA
CCGTCTGTGGCTACCAGTTACACTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTT
TGGGTCTGTTTTTTCATGCTTTGCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTAT

>42644_42644_1_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000332129_ANP32B_chr9_100756913_ENST00000339399_length(amino acids)=269AA_BP=35
MPRALAPRPPPLIHAQTLAPEGHGRPGGLLRQGGRQVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELS
ENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEV

--------------------------------------------------------------
>42644_42644_2_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000360529_ANP32B_chr9_100756913_ENST00000339399_length(transcript)=1280nt_BP=66nt
GCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAAT
TGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCA
GTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAA
CTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAA
AGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGAT
GGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGAT
GAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGAC
GATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAA
GGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGAAACAGAACTGTTCAGTATTGGT
TGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGACACCCACCCACCCAAAGAGCCA
AAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTTGTGGACTTCACCCCAACAAAAT
TGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAACCGTCTGTGGCTACCAGTTACA
CTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTTTGGGTCTGTTTTTTCATGCTTT
GCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTATTTTTAAGAATTTAAGCGAAATA

>42644_42644_2_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000360529_ANP32B_chr9_100756913_ENST00000339399_length(amino acids)=241AA_BP=7
MLRQGGRQVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKL
KDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEF

--------------------------------------------------------------
>42644_42644_3_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000422435_ANP32B_chr9_100756913_ENST00000339399_length(transcript)=1572nt_BP=358nt
GGGAGGTGGCTGCCGGGTGGGAGGTGTGTGCGCGTGTGCCGCGCCGTAGGGAGCGGCGGGTCGCGCCGCCGGCTGTCAGCTAGCTCCGCG
CCGCCGCCCGATGGCGCGAGGAGGCGCGCGGGCCCAGCCCCGGGGGGCCGGCCGCGGGTGAGCCCCTCGGCCTGCCGCCCGCGAGCATGT
CACCTCCAGCCGCCGCCGCCGCAGCCTCCGCCAGCCGCGCCCGCGCCCCCGCCTCCCGCAGCCGCAGCCGCTGCCTCGGGCATTGGCCCC
CAGACCCCCGCCTCTGATCCACGCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGT
TCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTT
AATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGG
TCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTT
GAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCT
GCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGA
GGAGGACGAAGAAGGAGAAGATGAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGA
TGTAGAAGGGGATGAGGACGACGATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGA
AGAGGAGGAAGAAGGTGGGAAAGGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGA
AACAGAACTGTTCAGTATTGGTTGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGA
CACCCACCCACCCAAAGAGCCAAAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTT
GTGGACTTCACCCCAACAAAATTGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAA
CCGTCTGTGGCTACCAGTTACACTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTT
TGGGTCTGTTTTTTCATGCTTTGCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTAT

>42644_42644_3_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000422435_ANP32B_chr9_100756913_ENST00000339399_length(amino acids)=269AA_BP=35
MPRALAPRPPPLIHAQTLAPEGHGRPGGLLRQGGRQVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELS
ENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEV

--------------------------------------------------------------
>42644_42644_4_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000461742_ANP32B_chr9_100756913_ENST00000339399_length(transcript)=1280nt_BP=66nt
GCCCAGACCCTAGCTCCAGAGGGCCATGGCCGGCCAGGGGGACTGCTGCGTCAAGGTGGCCGTCAGGTTCGAGAACTTGTCTTGGACAAT
TGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCA
GTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAA
CTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAA
AGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGAT
GGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGAAGGAGAAGAT
GAGGAAGACGAGGACGATGAGGATGGTGAAGAAGAGGAGTTTGATGAAGAAGATGATGAAGATGAAGATGTAGAAGGGGATGAGGACGAC
GATGAAGTCAGTGAGGAGGAAGAAGAATTTGGACTTGATGAAGAAGATGAAGATGAGGATGAGGATGAAGAGGAGGAAGAAGGTGGGAAA
GGTGAAAAGAGGAAGAGAGAAACAGATGATGAAGGAGAAGATGATTAAGACCCCAGATGACCTGCAGAAACAGAACTGTTCAGTATTGGT
TGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGACACCCACCCACCCAAAGAGCCA
AAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTTGTGGACTTCACCCCAACAAAAT
TGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAACCGTCTGTGGCTACCAGTTACA
CTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTTTGGGTCTGTTTTTTCATGCTTT
GCTTTTTAATTATTATTATTATTTTTTTTACATTAGGACATTTTATGTGACAACTGCCAAAAAAGTATTTTTAAGAATTTAAGCGAAATA

>42644_42644_4_KIF21B-ANP32B_KIF21B_chr1_200992471_ENST00000461742_ANP32B_chr9_100756913_ENST00000339399_length(amino acids)=241AA_BP=7
MLRQGGRQVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKL
KDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEF

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Fusion Gene PPI Analysis for KIF21B-ANP32B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000332129-134400_109913.6666666666666661625.0TRIM3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000360529-134400_109913.6666666666666661611.0TRIM3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000422435-135400_109913.6666666666666661638.0TRIM3
HgeneKIF21Bchr1:200992471chr9:100756913ENST00000461742-135400_109913.6666666666666661624.0TRIM3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF21B-ANP32B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF21B-ANP32B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource