FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KIF26A-CEP170B (FusionGDB2 ID:42660)

Fusion Gene Summary for KIF26A-CEP170B

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF26A-CEP170B
Fusion gene ID: 42660
HgeneTgene
Gene symbol

KIF26A

CEP170B

Gene ID

26153

283638

Gene namekinesin family member 26Acentrosomal protein 170B
Synonyms-CEP170R|FAM68C|KIAA0284
Cytomap

14q32.33

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF26AKIF26A variant proteincentrosomal protein of 170 kDa protein BCep170-related
Modification date2020031320200313
UniProtAcc

Q9ULI4

Q9Y4F5

Ensembl transtripts involved in fusion geneENST00000315264, ENST00000423312, 
ENST00000414716, ENST00000418279, 
ENST00000453495, ENST00000556508, 
Fusion gene scores* DoF score4 X 2 X 4=324 X 8 X 3=96
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF26A [Title/Abstract] AND CEP170B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF26A(104605625)-CEP170B(105359860), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIF26A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP170B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2O-01AKIF26Achr14

104605625

+CEP170Bchr14

105359860

+
ChimerDB4SARCTCGA-DX-AB2V-01AKIF26Achr14

104605625

+CEP170Bchr14

105359860

+


Top

Fusion Gene ORF analysis for KIF26A-CEP170B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000315264ENST00000414716KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
5UTR-3CDSENST00000315264ENST00000418279KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
5UTR-3CDSENST00000315264ENST00000453495KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
5UTR-3CDSENST00000315264ENST00000556508KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
In-frameENST00000423312ENST00000414716KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
In-frameENST00000423312ENST00000418279KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
In-frameENST00000423312ENST00000453495KIF26Achr14

104605625

+CEP170Bchr14

105359860

+
In-frameENST00000423312ENST00000556508KIF26Achr14

104605625

+CEP170Bchr14

105359860

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423312KIF26Achr14104605625+ENST00000556508CEP170Bchr14105359860+26992880914304
ENST00000423312KIF26Achr14104605625+ENST00000453495CEP170Bchr14105359860+26982880914304
ENST00000423312KIF26Achr14104605625+ENST00000414716CEP170Bchr14105359860+27272880914304
ENST00000423312KIF26Achr14104605625+ENST00000418279CEP170Bchr14105359860+27062880914304

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423312ENST00000556508KIF26Achr14104605625+CEP170Bchr14105359860+0.0330503020.9669497
ENST00000423312ENST00000453495KIF26Achr14104605625+CEP170Bchr14105359860+0.032991350.9670087
ENST00000423312ENST00000414716KIF26Achr14104605625+CEP170Bchr14105359860+0.0326863860.96731365
ENST00000423312ENST00000418279KIF26Achr14104605625+CEP170Bchr14105359860+0.0325725670.96742743

Top

Fusion Genomic Features for KIF26A-CEP170B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIF26Achr14104605625+CEP170Bchr14105359859+5.57E-081
KIF26Achr14104605625+CEP170Bchr14105359859+5.57E-081
KIF26Achr14104605625+CEP170Bchr14105359859+5.57E-081
KIF26Achr14104605625+CEP170Bchr14105359859+5.57E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for KIF26A-CEP170B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104605625/chr14:105359860)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF26A

Q9ULI4

CEP170B

Q9Y4F5

FUNCTION: Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). {ECO:0000250}.FUNCTION: Plays a role in microtubule organization. {ECO:0000250|UniProtKB:Q5SW79}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF26Achr14:104605625chr14:105359860ENST00000423312+2151784_1812961883.0Coiled coilOntology_term=ECO:0000255
HgeneKIF26Achr14:104605625chr14:105359860ENST00000423312+215371_725961883.0DomainKinesin motor
HgeneKIF26Achr14:104605625chr14:105359860ENST00000423312+215469_476961883.0Nucleotide bindingATP
TgeneCEP170Bchr14:104605625chr14:105359860ENST00000414716131923_7313461555.0DomainFHA
TgeneCEP170Bchr14:104605625chr14:105359860ENST00000556508121823_7313111520.0DomainFHA


Top

Fusion Gene Sequence for KIF26A-CEP170B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42660_42660_1_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000414716_length(transcript)=2727nt_BP=288nt
ATGGTCGGCCGCGGCGTCCCTCTGTGCGCTGCGCAGCCCGCGGTGGCCGAGGGCGGCCCGGCCCGCGAGCCGCCGCCGCTGCTGGAGGTG
TCCCCCCGAAAGAGGCTACCCGCCGGGCCCGACCAGGACCCATGCGGCAGCCGCCCTGCTCCCGAAGGCGCCGGGGCCGGCCCAGAGCAG
GGCCACTCGGCCGGCGGAGGCGGCTGGTGCCGCCACTGCCACACGAAGCTGGTGGAGCTCAAGCGACAGGCGTGGAAGCTGGTCAGCGGG
CCCGGGACCACCCTCCGGCTGGTGCAGCGCATCCCCGAGGCCAGCCTCAACTTCCAGAAGGTGCCGCCCGGCTCGCTGAACTCTCGGGAC
TTTGACCAGAACATGAACGACAGCTGTGAGGACGCCCTGGCCAACAAGACGCGGCCTCGGAACCGAGAGGAGGTGATCTTCGATAACCTG
ATGCTGAACCCGGTGTCCCAGCTGTCGCAGGCCATCCGTGAGAACACAGAGCACCTTGCCGAGAAGATGAAGATCCTCTTTCAGAACACA
GGGAGAGCTTGGGAGGACCTGGAAGCCAGGATCAACGCCGAGAACGAGGTGCCCATCCTGAAGACATCTAACAAGGAAATCAGCTCCATC
CTGAAGGAACTGAGGCGGGTGCAGAAACAGCTGGAAGTTATCAATGCCATCGTGGACCCCAGTGGGAGCCTGGACCTGCTCACAGGAAAC
AGGAGCTTGGCCAGCTCTGCACAGCCGGGGCTGGGGAAGGGCCGCGTGGCTGCCCAGAGCCCACCCTCACCCGCCTCAGCCGAGGCCCTG
CTGCCAGCCCTGCCCCTGAGGAATTTCCCACAGCGGGCCAGCTGTGGGCCTCCCAGCCTCCCGGACCCCACCTTCCTCCCTGATGCCGAG
AGGTTCCTGATCTAGGCCCCAGACCTGGCCAGGCCAGCCTCCCTGTGCGTGTGCGTCTCTGCCTTCCGTCCGCCGCACACCCGCCTGCCT
GGCCGCAGGTGGTTCTCCCTGAAGACCCCCACATGTGCCATATCCCTGTGGGCGGGTGCCTCCCACGCCCTTGCCCCCTCGTCAGCTCCC
AGCCAGCACCCTACTCACCCTGTCCAGCCCCATGGCCACCCCCACCCCTGCCTCGCCCCCTACAGGCCTCTGGGCCCAGCTCCTGGCCAG
GCTGCTGCCAAGGTCAAGCCCTCAAGGGCATTACCCCGCCTCCTCTTCATCACTGTTATTTTTGTCTTTAGCTTTAAAGGAAAGAGTTGT
TGGTGCCATTGCAGGTGCCCCCTCCAGGCCTGACTGGCTCCGCCAGGCACTAACCTGCCATAACCCTTTGTGCTGGCCTGCGGCCAGGCA
GAGGAAGAGAGGTCGACTGTGGGGTCATTTGGTGCCAAACATGGAGGTGGGCAGGCTCACCTGTTCCTGGGACTGTCTGAGATGGCAGGG
CACTTGCCCTGGTGGCTCCCACCTGACCCCAGGCCTTTTATAGGCAGGAGCCCCACTGCTTCCAGCCTCTGGTGCCAACACAGTTGCCAA
ACCCATTGAGCTTGGGGCTGCCCTGTGGAGGCCTCCTGGGTATGGACCAGGGGCTTGTTGAGAGCTGAGCCATGCACACAGGTGCAGACA
CCCCCCAACTCCCATGCACACGGCTAGTCCAGGCGCCTCCACGCTGCACCGTGAGGACTGCAGGGCATGTCCCCGTGAGGGGCTATGGGC
CTCTGTAGGTGGGCTTCCAAGGTCCTGGGTGCAGCCGGGTGCATGGCAGCCCTTCTGGCGGGGGTGAGCGCACGACCAAAGTCACTGGAA
GCCGGGTTTCCGGAAGCTCGCAGCTTGGCCTGCACCACACGCCCTCCCCTTTTGGCTTCACGCCATCAGGCCTCAAGTGGGCATGGGGGC
AGGGACGGGCCCAGGAACTGTTGTTTTCTCAGGATTCTTTCAGCTGGGAACATGGCAGGTGAGCAGAGCTTGGTGCCTCTGCCGTGGCCC
CTGCTGGGGCAGCCCGTGTTGCCGGAGCCTCTAAGCCAAAGAGCCCGTTGGCCGTGGTTGGTGGGGGTGGACGTGGGGGTGTCCCACCTG
GACCAGACTGGCGTGGGTGAGCTCCACACCCTGCCTGGCAATGGTATGAGAGTCGGACCTGGACAGGGCCAGCTGCTGGGGGAGCGGCAC
TGGGGACTGGAGGCTGGAAGCGGGTGGTGTGTGTCCCCTGTTTACTTTTAGCTGAGCTGGGGTTGGGTGTACGGGTTCTGTTCCTCTGAG
CCTGCGGCCCACCTGATGTTTACGTGTGTGTGTGAGGGGGGGCGGGGGTGGCAGGTGTCCCCCCCTGGTCCCCGCCCCAAGAGCCTGCTG
TCTGTATGGAGGAGGTGCTAGCCCGGTCCACCGGGCTGCTGCCCACCCCTGCATGCCCCAGTTGCCCACCCCGCCTGCCCCTGGACATGA
AGTGGTCACGCTTCATCCACGGCTCCTTCCCACCCCTCGGCAGTGGCTGTGCAATGTTTTAAGTTCACAAGTTCCTGCTCCTCCCCACAC
TGAGCTCCTTTGTTCCTCCCCCTCCAGCCTTTGCCTGGGAACTGGTCCTTGTTTGCCGGGCTTCTCGGAGGGTTCACTGTACATTCGTTC
TCAGGTGGTCTTGTGGCTGTCTTTCGGAAAATGGTTATTTTATATGATTTGTCATGGAATTTGTTCTAATAAATCATTCTTCTATCACAT

>42660_42660_1_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000414716_length(amino acids)=304AA_BP=49
MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSG
PGTTLRLVQRIPEASLNFQKVPPGSLNSRDFDQNMNDSCEDALANKTRPRNREEVIFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNT
GRAWEDLEARINAENEVPILKTSNKEISSILKELRRVQKQLEVINAIVDPSGSLDLLTGNRSLASSAQPGLGKGRVAAQSPPSPASAEAL

--------------------------------------------------------------
>42660_42660_2_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000418279_length(transcript)=2706nt_BP=288nt
ATGGTCGGCCGCGGCGTCCCTCTGTGCGCTGCGCAGCCCGCGGTGGCCGAGGGCGGCCCGGCCCGCGAGCCGCCGCCGCTGCTGGAGGTG
TCCCCCCGAAAGAGGCTACCCGCCGGGCCCGACCAGGACCCATGCGGCAGCCGCCCTGCTCCCGAAGGCGCCGGGGCCGGCCCAGAGCAG
GGCCACTCGGCCGGCGGAGGCGGCTGGTGCCGCCACTGCCACACGAAGCTGGTGGAGCTCAAGCGACAGGCGTGGAAGCTGGTCAGCGGG
CCCGGGACCACCCTCCGGCTGGTGCAGCGCATCCCCGAGGCCAGCCTCAACTTCCAGAAGGTGCCGCCCGGCTCGCTGAACTCTCGGGAC
TTTGACCAGAACATGAACGACAGCTGTGAGGACGCCCTGGCCAACAAGACGCGGCCTCGGAACCGAGAGGAGGTGATCTTCGATAACCTG
ATGCTGAACCCGGTGTCCCAGCTGTCGCAGGCCATCCGTGAGAACACAGAGCACCTTGCCGAGAAGATGAAGATCCTCTTTCAGAACACA
GGGAGAGCTTGGGAGGACCTGGAAGCCAGGATCAACGCCGAGAACGAGGTGCCCATCCTGAAGACATCTAACAAGGAAATCAGCTCCATC
CTGAAGGAACTGAGGCGGGTGCAGAAACAGCTGGAAGTTATCAATGCCATCGTGGACCCCAGTGGGAGCCTGGACCTGCTCACAGGAAAC
AGGAGCTTGGCCAGCTCTGCACAGCCGGGGCTGGGGAAGGGCCGCGTGGCTGCCCAGAGCCCACCCTCACCCGCCTCAGCCGAGGCCCTG
CTGCCAGCCCTGCCCCTGAGGAATTTCCCACAGCGGGCCAGCTGTGGGCCTCCCAGCCTCCCGGACCCCACCTTCCTCCCTGATGCCGAG
AGGTTCCTGATCTAGGCCCCAGACCTGGCCAGGCCAGCCTCCCTGTGCGTGTGCGTCTCTGCCTTCCGTCCGCCGCACACCCGCCTGCCT
GGCCGCAGGTGGTTCTCCCTGAAGACCCCCACATGTGCCATATCCCTGTGGGCGGGTGCCTCCCACGCCCTTGCCCCCTCGTCAGCTCCC
AGCCAGCACCCTACTCACCCTGTCCAGCCCCATGGCCACCCCCACCCCTGCCTCGCCCCCTACAGGCCTCTGGGCCCAGCTCCTGGCCAG
GCTGCTGCCAAGGTCAAGCCCTCAAGGGCATTACCCCGCCTCCTCTTCATCACTGTTATTTTTGTCTTTAGCTTTAAAGGAAAGAGTTGT
TGGTGCCATTGCAGGTGCCCCCTCCAGGCCTGACTGGCTCCGCCAGGCACTAACCTGCCATAACCCTTTGTGCTGGCCTGCGGCCAGGCA
GAGGAAGAGAGGTCGACTGTGGGGTCATTTGGTGCCAAACATGGAGGTGGGCAGGCTCACCTGTTCCTGGGACTGTCTGAGATGGCAGGG
CACTTGCCCTGGTGGCTCCCACCTGACCCCAGGCCTTTTATAGGCAGGAGCCCCACTGCTTCCAGCCTCTGGTGCCAACACAGTTGCCAA
ACCCATTGAGCTTGGGGCTGCCCTGTGGAGGCCTCCTGGGTATGGACCAGGGGCTTGTTGAGAGCTGAGCCATGCACACAGGTGCAGACA
CCCCCCAACTCCCATGCACACGGCTAGTCCAGGCGCCTCCACGCTGCACCGTGAGGACTGCAGGGCATGTCCCCGTGAGGGGCTATGGGC
CTCTGTAGGTGGGCTTCCAAGGTCCTGGGTGCAGCCGGGTGCATGGCAGCCCTTCTGGCGGGGGTGAGCGCACGACCAAAGTCACTGGAA
GCCGGGTTTCCGGAAGCTCGCAGCTTGGCCTGCACCACACGCCCTCCCCTTTTGGCTTCACGCCATCAGGCCTCAAGTGGGCATGGGGGC
AGGGACGGGCCCAGGAACTGTTGTTTTCTCAGGATTCTTTCAGCTGGGAACATGGCAGGTGAGCAGAGCTTGGTGCCTCTGCCGTGGCCC
CTGCTGGGGCAGCCCGTGTTGCCGGAGCCTCTAAGCCAAAGAGCCCGTTGGCCGTGGTTGGTGGGGGTGGACGTGGGGGTGTCCCACCTG
GACCAGACTGGCGTGGGTGAGCTCCACACCCTGCCTGGCAATGGTATGAGAGTCGGACCTGGACAGGGCCAGCTGCTGGGGGAGCGGCAC
TGGGGACTGGAGGCTGGAAGCGGGTGGTGTGTGTCCCCTGTTTACTTTTAGCTGAGCTGGGGTTGGGTGTACGGGTTCTGTTCCTCTGAG
CCTGCGGCCCACCTGATGTTTACGTGTGTGTGTGAGGGGGGGCGGGGGTGGCAGGTGTCCCCCCCTGGTCCCCGCCCCAAGAGCCTGCTG
TCTGTATGGAGGAGGTGCTAGCCCGGTCCACCGGGCTGCTGCCCACCCCTGCATGCCCCAGTTGCCCACCCCGCCTGCCCCTGGACATGA
AGTGGTCACGCTTCATCCACGGCTCCTTCCCACCCCTCGGCAGTGGCTGTGCAATGTTTTAAGTTCACAAGTTCCTGCTCCTCCCCACAC
TGAGCTCCTTTGTTCCTCCCCCTCCAGCCTTTGCCTGGGAACTGGTCCTTGTTTGCCGGGCTTCTCGGAGGGTTCACTGTACATTCGTTC
TCAGGTGGTCTTGTGGCTGTCTTTCGGAAAATGGTTATTTTATATGATTTGTCATGGAATTTGTTCTAATAAATCATTCTTCTATCACAT

>42660_42660_2_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000418279_length(amino acids)=304AA_BP=49
MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSG
PGTTLRLVQRIPEASLNFQKVPPGSLNSRDFDQNMNDSCEDALANKTRPRNREEVIFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNT
GRAWEDLEARINAENEVPILKTSNKEISSILKELRRVQKQLEVINAIVDPSGSLDLLTGNRSLASSAQPGLGKGRVAAQSPPSPASAEAL

--------------------------------------------------------------
>42660_42660_3_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000453495_length(transcript)=2698nt_BP=288nt
ATGGTCGGCCGCGGCGTCCCTCTGTGCGCTGCGCAGCCCGCGGTGGCCGAGGGCGGCCCGGCCCGCGAGCCGCCGCCGCTGCTGGAGGTG
TCCCCCCGAAAGAGGCTACCCGCCGGGCCCGACCAGGACCCATGCGGCAGCCGCCCTGCTCCCGAAGGCGCCGGGGCCGGCCCAGAGCAG
GGCCACTCGGCCGGCGGAGGCGGCTGGTGCCGCCACTGCCACACGAAGCTGGTGGAGCTCAAGCGACAGGCGTGGAAGCTGGTCAGCGGG
CCCGGGACCACCCTCCGGCTGGTGCAGCGCATCCCCGAGGCCAGCCTCAACTTCCAGAAGGTGCCGCCCGGCTCGCTGAACTCTCGGGAC
TTTGACCAGAACATGAACGACAGCTGTGAGGACGCCCTGGCCAACAAGACGCGGCCTCGGAACCGAGAGGAGGTGATCTTCGATAACCTG
ATGCTGAACCCGGTGTCCCAGCTGTCGCAGGCCATCCGTGAGAACACAGAGCACCTTGCCGAGAAGATGAAGATCCTCTTTCAGAACACA
GGGAGAGCTTGGGAGGACCTGGAAGCCAGGATCAACGCCGAGAACGAGGTGCCCATCCTGAAGACATCTAACAAGGAAATCAGCTCCATC
CTGAAGGAACTGAGGCGGGTGCAGAAACAGCTGGAAGTTATCAATGCCATCGTGGACCCCAGTGGGAGCCTGGACCTGCTCACAGGAAAC
AGGAGCTTGGCCAGCTCTGCACAGCCGGGGCTGGGGAAGGGCCGCGTGGCTGCCCAGAGCCCACCCTCACCCGCCTCAGCCGAGGCCCTG
CTGCCAGCCCTGCCCCTGAGGAATTTCCCACAGCGGGCCAGCTGTGGGCCTCCCAGCCTCCCGGACCCCACCTTCCTCCCTGATGCCGAG
AGGTTCCTGATCTAGGCCCCAGACCTGGCCAGGCCAGCCTCCCTGTGCGTGTGCGTCTCTGCCTTCCGTCCGCCGCACACCCGCCTGCCT
GGCCGCAGGTGGTTCTCCCTGAAGACCCCCACATGTGCCATATCCCTGTGGGCGGGTGCCTCCCACGCCCTTGCCCCCTCGTCAGCTCCC
AGCCAGCACCCTACTCACCCTGTCCAGCCCCATGGCCACCCCCACCCCTGCCTCGCCCCCTACAGGCCTCTGGGCCCAGCTCCTGGCCAG
GCTGCTGCCAAGGTCAAGCCCTCAAGGGCATTACCCCGCCTCCTCTTCATCACTGTTATTTTTGTCTTTAGCTTTAAAGGAAAGAGTTGT
TGGTGCCATTGCAGGTGCCCCCTCCAGGCCTGACTGGCTCCGCCAGGCACTAACCTGCCATAACCCTTTGTGCTGGCCTGCGGCCAGGCA
GAGGAAGAGAGGTCGACTGTGGGGTCATTTGGTGCCAAACATGGAGGTGGGCAGGCTCACCTGTTCCTGGGACTGTCTGAGATGGCAGGG
CACTTGCCCTGGTGGCTCCCACCTGACCCCAGGCCTTTTATAGGCAGGAGCCCCACTGCTTCCAGCCTCTGGTGCCAACACAGTTGCCAA
ACCCATTGAGCTTGGGGCTGCCCTGTGGAGGCCTCCTGGGTATGGACCAGGGGCTTGTTGAGAGCTGAGCCATGCACACAGGTGCAGACA
CCCCCCAACTCCCATGCACACGGCTAGTCCAGGCGCCTCCACGCTGCACCGTGAGGACTGCAGGGCATGTCCCCGTGAGGGGCTATGGGC
CTCTGTAGGTGGGCTTCCAAGGTCCTGGGTGCAGCCGGGTGCATGGCAGCCCTTCTGGCGGGGGTGAGCGCACGACCAAAGTCACTGGAA
GCCGGGTTTCCGGAAGCTCGCAGCTTGGCCTGCACCACACGCCCTCCCCTTTTGGCTTCACGCCATCAGGCCTCAAGTGGGCATGGGGGC
AGGGACGGGCCCAGGAACTGTTGTTTTCTCAGGATTCTTTCAGCTGGGAACATGGCAGGTGAGCAGAGCTTGGTGCCTCTGCCGTGGCCC
CTGCTGGGGCAGCCCGTGTTGCCGGAGCCTCTAAGCCAAAGAGCCCGTTGGCCGTGGTTGGTGGGGGTGGACGTGGGGGTGTCCCACCTG
GACCAGACTGGCGTGGGTGAGCTCCACACCCTGCCTGGCAATGGTATGAGAGTCGGACCTGGACAGGGCCAGCTGCTGGGGGAGCGGCAC
TGGGGACTGGAGGCTGGAAGCGGGTGGTGTGTGTCCCCTGTTTACTTTTAGCTGAGCTGGGGTTGGGTGTACGGGTTCTGTTCCTCTGAG
CCTGCGGCCCACCTGATGTTTACGTGTGTGTGTGAGGGGGGGCGGGGGTGGCAGGTGTCCCCCCCTGGTCCCCGCCCCAAGAGCCTGCTG
TCTGTATGGAGGAGGTGCTAGCCCGGTCCACCGGGCTGCTGCCCACCCCTGCATGCCCCAGTTGCCCACCCCGCCTGCCCCTGGACATGA
AGTGGTCACGCTTCATCCACGGCTCCTTCCCACCCCTCGGCAGTGGCTGTGCAATGTTTTAAGTTCACAAGTTCCTGCTCCTCCCCACAC
TGAGCTCCTTTGTTCCTCCCCCTCCAGCCTTTGCCTGGGAACTGGTCCTTGTTTGCCGGGCTTCTCGGAGGGTTCACTGTACATTCGTTC

>42660_42660_3_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000453495_length(amino acids)=304AA_BP=49
MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSG
PGTTLRLVQRIPEASLNFQKVPPGSLNSRDFDQNMNDSCEDALANKTRPRNREEVIFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNT
GRAWEDLEARINAENEVPILKTSNKEISSILKELRRVQKQLEVINAIVDPSGSLDLLTGNRSLASSAQPGLGKGRVAAQSPPSPASAEAL

--------------------------------------------------------------
>42660_42660_4_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000556508_length(transcript)=2699nt_BP=288nt
ATGGTCGGCCGCGGCGTCCCTCTGTGCGCTGCGCAGCCCGCGGTGGCCGAGGGCGGCCCGGCCCGCGAGCCGCCGCCGCTGCTGGAGGTG
TCCCCCCGAAAGAGGCTACCCGCCGGGCCCGACCAGGACCCATGCGGCAGCCGCCCTGCTCCCGAAGGCGCCGGGGCCGGCCCAGAGCAG
GGCCACTCGGCCGGCGGAGGCGGCTGGTGCCGCCACTGCCACACGAAGCTGGTGGAGCTCAAGCGACAGGCGTGGAAGCTGGTCAGCGGG
CCCGGGACCACCCTCCGGCTGGTGCAGCGCATCCCCGAGGCCAGCCTCAACTTCCAGAAGGTGCCGCCCGGCTCGCTGAACTCTCGGGAC
TTTGACCAGAACATGAACGACAGCTGTGAGGACGCCCTGGCCAACAAGACGCGGCCTCGGAACCGAGAGGAGGTGATCTTCGATAACCTG
ATGCTGAACCCGGTGTCCCAGCTGTCGCAGGCCATCCGTGAGAACACAGAGCACCTTGCCGAGAAGATGAAGATCCTCTTTCAGAACACA
GGGAGAGCTTGGGAGGACCTGGAAGCCAGGATCAACGCCGAGAACGAGGTGCCCATCCTGAAGACATCTAACAAGGAAATCAGCTCCATC
CTGAAGGAACTGAGGCGGGTGCAGAAACAGCTGGAAGTTATCAATGCCATCGTGGACCCCAGTGGGAGCCTGGACCTGCTCACAGGAAAC
AGGAGCTTGGCCAGCTCTGCACAGCCGGGGCTGGGGAAGGGCCGCGTGGCTGCCCAGAGCCCACCCTCACCCGCCTCAGCCGAGGCCCTG
CTGCCAGCCCTGCCCCTGAGGAATTTCCCACAGCGGGCCAGCTGTGGGCCTCCCAGCCTCCCGGACCCCACCTTCCTCCCTGATGCCGAG
AGGTTCCTGATCTAGGCCCCAGACCTGGCCAGGCCAGCCTCCCTGTGCGTGTGCGTCTCTGCCTTCCGTCCGCCGCACACCCGCCTGCCT
GGCCGCAGGTGGTTCTCCCTGAAGACCCCCACATGTGCCATATCCCTGTGGGCGGGTGCCTCCCACGCCCTTGCCCCCTCGTCAGCTCCC
AGCCAGCACCCTACTCACCCTGTCCAGCCCCATGGCCACCCCCACCCCTGCCTCGCCCCCTACAGGCCTCTGGGCCCAGCTCCTGGCCAG
GCTGCTGCCAAGGTCAAGCCCTCAAGGGCATTACCCCGCCTCCTCTTCATCACTGTTATTTTTGTCTTTAGCTTTAAAGGAAAGAGTTGT
TGGTGCCATTGCAGGTGCCCCCTCCAGGCCTGACTGGCTCCGCCAGGCACTAACCTGCCATAACCCTTTGTGCTGGCCTGCGGCCAGGCA
GAGGAAGAGAGGTCGACTGTGGGGTCATTTGGTGCCAAACATGGAGGTGGGCAGGCTCACCTGTTCCTGGGACTGTCTGAGATGGCAGGG
CACTTGCCCTGGTGGCTCCCACCTGACCCCAGGCCTTTTATAGGCAGGAGCCCCACTGCTTCCAGCCTCTGGTGCCAACACAGTTGCCAA
ACCCATTGAGCTTGGGGCTGCCCTGTGGAGGCCTCCTGGGTATGGACCAGGGGCTTGTTGAGAGCTGAGCCATGCACACAGGTGCAGACA
CCCCCCAACTCCCATGCACACGGCTAGTCCAGGCGCCTCCACGCTGCACCGTGAGGACTGCAGGGCATGTCCCCGTGAGGGGCTATGGGC
CTCTGTAGGTGGGCTTCCAAGGTCCTGGGTGCAGCCGGGTGCATGGCAGCCCTTCTGGCGGGGGTGAGCGCACGACCAAAGTCACTGGAA
GCCGGGTTTCCGGAAGCTCGCAGCTTGGCCTGCACCACACGCCCTCCCCTTTTGGCTTCACGCCATCAGGCCTCAAGTGGGCATGGGGGC
AGGGACGGGCCCAGGAACTGTTGTTTTCTCAGGATTCTTTCAGCTGGGAACATGGCAGGTGAGCAGAGCTTGGTGCCTCTGCCGTGGCCC
CTGCTGGGGCAGCCCGTGTTGCCGGAGCCTCTAAGCCAAAGAGCCCGTTGGCCGTGGTTGGTGGGGGTGGACGTGGGGGTGTCCCACCTG
GACCAGACTGGCGTGGGTGAGCTCCACACCCTGCCTGGCAATGGTATGAGAGTCGGACCTGGACAGGGCCAGCTGCTGGGGGAGCGGCAC
TGGGGACTGGAGGCTGGAAGCGGGTGGTGTGTGTCCCCTGTTTACTTTTAGCTGAGCTGGGGTTGGGTGTACGGGTTCTGTTCCTCTGAG
CCTGCGGCCCACCTGATGTTTACGTGTGTGTGTGAGGGGGGGCGGGGGTGGCAGGTGTCCCCCCCTGGTCCCCGCCCCAAGAGCCTGCTG
TCTGTATGGAGGAGGTGCTAGCCCGGTCCACCGGGCTGCTGCCCACCCCTGCATGCCCCAGTTGCCCACCCCGCCTGCCCCTGGACATGA
AGTGGTCACGCTTCATCCACGGCTCCTTCCCACCCCTCGGCAGTGGCTGTGCAATGTTTTAAGTTCACAAGTTCCTGCTCCTCCCCACAC
TGAGCTCCTTTGTTCCTCCCCCTCCAGCCTTTGCCTGGGAACTGGTCCTTGTTTGCCGGGCTTCTCGGAGGGTTCACTGTACATTCGTTC

>42660_42660_4_KIF26A-CEP170B_KIF26A_chr14_104605625_ENST00000423312_CEP170B_chr14_105359860_ENST00000556508_length(amino acids)=304AA_BP=49
MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQGHSAGGGGWCRHCHTKLVELKRQAWKLVSG
PGTTLRLVQRIPEASLNFQKVPPGSLNSRDFDQNMNDSCEDALANKTRPRNREEVIFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNT
GRAWEDLEARINAENEVPILKTSNKEISSILKELRRVQKQLEVINAIVDPSGSLDLLTGNRSLASSAQPGLGKGRVAAQSPPSPASAEAL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIF26A-CEP170B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KIF26A-CEP170B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KIF26A-CEP170B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource