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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIF3A-PDLIM4 (FusionGDB2 ID:42689)

Fusion Gene Summary for KIF3A-PDLIM4

Fusion gene summary

Fusion gene information	Fusion gene name: KIF3A-PDLIM4
	Fusion gene ID: 42689
		Hgene	Tgene
	Gene symbol	KIF3A	PDLIM4
	Gene ID	11127	8572
	Gene name	kinesin family member 3A	PDZ and LIM domain 4
	Synonyms	FLA10\|KLP-20	RIL
	Cytomap	5q31.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	kinesin-like protein KIF3Akinesin family protein 3Amicrotubule plus end-directed kinesin motor 3A	PDZ and LIM domain protein 4LIM domain proteinLIM protein RILenigma homologreversion-induced LIM protein
	Modification date	20200313	20200313
	UniProtAcc	Q9Y496	.
	Ensembl transtripts involved in fusion gene	ENST00000378735, ENST00000378746, ENST00000403231, ENST00000487055,	ENST00000484620, ENST00000253754, ENST00000379018,
Fusion gene scores	* DoF score	5 X 5 X 2=50	4 X 2 X 4=32
	# samples	5	4
	** MAII score	log2(5/50*10)=0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KIF3A [Title/Abstract] AND PDLIM4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIF3A(132073106)-PDLIM4(131598302), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PDLIM4	GO:0031532	actin cytoskeleton reorganization	21636573

Fusion gene breakpoints across KIF3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDLIM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-8238-01A	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+

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Fusion Gene ORF analysis for KIF3A-PDLIM4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000378735	ENST00000484620	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
5CDS-intron	ENST00000378746	ENST00000484620	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
5CDS-intron	ENST00000403231	ENST00000484620	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
In-frame	ENST00000378735	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
In-frame	ENST00000378735	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
In-frame	ENST00000378746	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
In-frame	ENST00000378746	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
In-frame	ENST00000403231	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
In-frame	ENST00000403231	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
intron-3CDS	ENST00000487055	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
intron-3CDS	ENST00000487055	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+
intron-intron	ENST00000487055	ENST00000484620	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378746	KIF3A	chr5	132073106	-	ENST00000253754	PDLIM4	chr5	131598302	+	2350	225	138	1124	328
ENST00000378746	KIF3A	chr5	132073106	-	ENST00000379018	PDLIM4	chr5	131598302	+	1110	225	138	872	244
ENST00000378735	KIF3A	chr5	132073106	-	ENST00000253754	PDLIM4	chr5	131598302	+	2284	159	72	1058	328
ENST00000378735	KIF3A	chr5	132073106	-	ENST00000379018	PDLIM4	chr5	131598302	+	1044	159	72	806	244
ENST00000403231	KIF3A	chr5	132073106	-	ENST00000253754	PDLIM4	chr5	131598302	+	2131	6	0	905	301
ENST00000403231	KIF3A	chr5	132073106	-	ENST00000379018	PDLIM4	chr5	131598302	+	891	6	0	653	217

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378746	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+	0.09395748	0.9060425
ENST00000378746	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+	0.16878004	0.83122
ENST00000378735	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+	0.084945954	0.9150541
ENST00000378735	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+	0.11432276	0.8856773
ENST00000403231	ENST00000253754	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+	0.08316314	0.91683686
ENST00000403231	ENST00000379018	KIF3A	chr5	132073106	-	PDLIM4	chr5	131598302	+	0.08575824	0.9142418

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Fusion Genomic Features for KIF3A-PDLIM4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KIF3A	chr5	132073105	-	PDLIM4	chr5	131598301	+	6.63E-07	0.9999993
KIF3A	chr5	132073105	-	PDLIM4	chr5	131598301	+	6.63E-07	0.9999993

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIF3A-PDLIM4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:132073106/chr5:131598302)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIF3A Q9Y496	.
FUNCTION: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250\|UniProtKB:P28741}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PDLIM4

chr5:132073106

chr5:131598302

ENST00000253754

253_312

331.0

Domain

LIM zinc-binding

Tgene

PDLIM4

chr5:132073106

chr5:131598302

ENST00000379018

253_312

247.0

Domain

LIM zinc-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIF3A

chr5:132073106

chr5:131598302

ENST00000378746

355_590

700.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

KIF3A

chr5:132073106

chr5:131598302

ENST00000378746

14_345

700.0

Domain

Kinesin motor

Hgene

KIF3A

chr5:132073106

chr5:131598302

ENST00000378746

100_107

700.0

Nucleotide binding

ATP

Hgene

KIF3A

chr5:132073106

chr5:131598302

ENST00000378746

697_699

700.0

Region

Note=Globular

Tgene

PDLIM4

chr5:132073106

chr5:131598302

ENST00000253754

1_84

331.0

Domain

PDZ

Tgene

PDLIM4

chr5:132073106

chr5:131598302

ENST00000379018

1_84

247.0

Domain

PDZ

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Fusion Gene Sequence for KIF3A-PDLIM4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42689_42689_1_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378735_PDLIM4_chr5_131598302_ENST00000253754_length(transcript)=2284nt_BP=159nt
CGGCTGCGCACTGGGCGCTCTCGCCCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCG
CACCCGGTGTCGCTGGGCTGCACCCCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCT
GCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGC
ATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAG
GCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGAT
GGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAG
ATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCC
GAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTA
GAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCCAGCAAGCTGGGCGCTCCGCTGAGCGGC
CTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGC
TTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCG
CGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGC
CTGCTTCTTAAGGTCCCTGCTCGGCCGGTGTAAATATGTTTCACCCTGTCCCTCTAATAAAGCTCCTCTGCTCCACCTTGAACCTGTCAC
CTGGCCTGCCACCCTCCTGCGCAGGCCATGCATGGCTCCCGAGTACAGTAGTATCTGCTTAGGTGCCAGGCATGTCCTAGGCTCTGGGTG
CAGTAGTGAGCAGGACGGGTACCATGCTGCCCTGAAGGGGGCCACAGCCTGGGTGGAAGGCAGACCTGAATCACAACGGGCCAGCTCTAG
TAATACGAAGGTGAGGTCTGGGATGCTGCGTGCGGCGCGACGACAGGAGGTATGACCTGGGTGGGGTCAGGGAAAGTCTTAGCTGAGAAC
TAAGAGATGAGGGAGGCACAAACTCTGCACGGGGGAACTGTGTGTGCAAAGGTGAGCTGGGGGCGAGAAAGGCCTCTGTGGCCGTCATCG
GCACTAGCGGGTTGGGGGTGGTGGTGGGGTGCTGGCAGCCTCAGGAGCGATCGCTCCCCTGGAGAGGGTGATTGAGTGTGGAGATCACCG
GGGCCGCCGCGGGCCGTCTGCACTTCTGTTCCAGGTTTTTCTGGCATTTTCTGTTCCAGGTTTCTTCCACCCACGAGCACTTTATTCTCC
TCCGAGACCCCCTTTTCTTCCCCTTCCTCTCTCCCCCACCAGGGGGCGCGCTTAAATTTCCAGACAGAGACCAGAAGGAAGGTTTAGAAA
GAAAAGAACACTTGCCCAGGGCAGCTTTGCCCTCCAAGAGGCTCCCTCCTGTCTCTAAGTCAATTCCACCCCTCCTCGAAGTCCCGGCTT
CCACCCCTCTCCTCAGAGTCCCGGCGTTTACCTCGTGGTGTGTTTGCCTTGGGCCTTTCATGCCCCGGCTGCACACATCGTCTGTGAATT
GTGGCTGTTCACTCCCGAGGATGTGTCCTAGACTCCGGGTCGCGTGGATCTACCCTCTAGTTTACTTGCTCGGGAGAAGAAACTGACTCG
TTTTATTTAGTGCCTATTTAGCGAGCCCAGAGTAACGTACATTTGTGCTGTTTTCAATTTTGTGCTATCGCAAATCACAAAAAAACTGTT
ATCAATTCACATTCATCATCAGCACGAGACCCATTTCCTTGTGCTCCTGCCAGCTCAGGATATTATGTTTCTTTTTTCATTTTTGCCAGT

>42689_42689_1_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378735_PDLIM4_chr5_131598302_ENST00000253754_length(amino acids)=328AA_BP=29
MAILSAHPVSLGCTPGGDVRRAREGAKMPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAP
DDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDC
RVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDK

--------------------------------------------------------------
>42689_42689_2_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378735_PDLIM4_chr5_131598302_ENST00000379018_length(transcript)=1044nt_BP=159nt
CGGCTGCGCACTGGGCGCTCTCGCCCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCG
CACCCGGTGTCGCTGGGCTGCACCCCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCT
GCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGC
ATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAG
GCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGAT
GGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAG
ATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCC
GAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTA
GAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACC
TCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACG
TGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGGCCGG

>42689_42689_2_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378735_PDLIM4_chr5_131598302_ENST00000379018_length(amino acids)=244AA_BP=29
MAILSAHPVSLGCTPGGDVRRAREGAKMPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAP
DDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDC

--------------------------------------------------------------
>42689_42689_3_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378746_PDLIM4_chr5_131598302_ENST00000253754_length(transcript)=2350nt_BP=225nt
GCGCAGGCGTAATTCAAGGGCCGAGAGAGCCTGAGACTGGGCTTGGGGCGGGGCGAGCTCGGAATGCGGCTGCGCACTGGGCGCTCTCGC
CCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCGCACCCGGTGTCGCTGGGCTGCACC
CCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGA
GACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTC
ACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCT
GAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCA
TATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCA
CCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAG
CCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGG
CCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCCAGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACG
CGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTG
AACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTAC
GACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGG
CCGGTGTAAATATGTTTCACCCTGTCCCTCTAATAAAGCTCCTCTGCTCCACCTTGAACCTGTCACCTGGCCTGCCACCCTCCTGCGCAG
GCCATGCATGGCTCCCGAGTACAGTAGTATCTGCTTAGGTGCCAGGCATGTCCTAGGCTCTGGGTGCAGTAGTGAGCAGGACGGGTACCA
TGCTGCCCTGAAGGGGGCCACAGCCTGGGTGGAAGGCAGACCTGAATCACAACGGGCCAGCTCTAGTAATACGAAGGTGAGGTCTGGGAT
GCTGCGTGCGGCGCGACGACAGGAGGTATGACCTGGGTGGGGTCAGGGAAAGTCTTAGCTGAGAACTAAGAGATGAGGGAGGCACAAACT
CTGCACGGGGGAACTGTGTGTGCAAAGGTGAGCTGGGGGCGAGAAAGGCCTCTGTGGCCGTCATCGGCACTAGCGGGTTGGGGGTGGTGG
TGGGGTGCTGGCAGCCTCAGGAGCGATCGCTCCCCTGGAGAGGGTGATTGAGTGTGGAGATCACCGGGGCCGCCGCGGGCCGTCTGCACT
TCTGTTCCAGGTTTTTCTGGCATTTTCTGTTCCAGGTTTCTTCCACCCACGAGCACTTTATTCTCCTCCGAGACCCCCTTTTCTTCCCCT
TCCTCTCTCCCCCACCAGGGGGCGCGCTTAAATTTCCAGACAGAGACCAGAAGGAAGGTTTAGAAAGAAAAGAACACTTGCCCAGGGCAG
CTTTGCCCTCCAAGAGGCTCCCTCCTGTCTCTAAGTCAATTCCACCCCTCCTCGAAGTCCCGGCTTCCACCCCTCTCCTCAGAGTCCCGG
CGTTTACCTCGTGGTGTGTTTGCCTTGGGCCTTTCATGCCCCGGCTGCACACATCGTCTGTGAATTGTGGCTGTTCACTCCCGAGGATGT
GTCCTAGACTCCGGGTCGCGTGGATCTACCCTCTAGTTTACTTGCTCGGGAGAAGAAACTGACTCGTTTTATTTAGTGCCTATTTAGCGA
GCCCAGAGTAACGTACATTTGTGCTGTTTTCAATTTTGTGCTATCGCAAATCACAAAAAAACTGTTATCAATTCACATTCATCATCAGCA
CGAGACCCATTTCCTTGTGCTCCTGCCAGCTCAGGATATTATGTTTCTTTTTTCATTTTTGCCAGTCTGTTAAGTAAAATGTCATATGCG

>42689_42689_3_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378746_PDLIM4_chr5_131598302_ENST00000253754_length(amino acids)=328AA_BP=29
MAILSAHPVSLGCTPGGDVRRAREGAKMPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAP
DDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDC
RVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDK

--------------------------------------------------------------
>42689_42689_4_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378746_PDLIM4_chr5_131598302_ENST00000379018_length(transcript)=1110nt_BP=225nt
GCGCAGGCGTAATTCAAGGGCCGAGAGAGCCTGAGACTGGGCTTGGGGCGGGGCGAGCTCGGAATGCGGCTGCGCACTGGGCGCTCTCGC
CCGAGAAGCCGCAGTCTCGAGAGCGTCAACGAGGTGTTTCGGTAGTCTCTGGCCATCCTTTCTGCGCACCCGGTGTCGCTGGGCTGCACC
CCGGGCGGGGACGTCCGCCGGGCACGGGAGGGGGCCAAGATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGA
GACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTCATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTC
ACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCCAGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCT
GAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCCTCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCA
TATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGCAGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCA
CCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGCCGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAG
CCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGCTCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCA
TCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTC
TGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCA
AGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGGCCGGTGTAAATATGTTTCACCCTGTCCC

>42689_42689_4_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000378746_PDLIM4_chr5_131598302_ENST00000379018_length(amino acids)=244AA_BP=29
MAILSAHPVSLGCTPGGDVRRAREGAKMPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAP
DDSKAQAHRIHIDPEIQDGSPTTSRRPSGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDC

--------------------------------------------------------------
>42689_42689_5_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000403231_PDLIM4_chr5_131598302_ENST00000253754_length(transcript)=2131nt_BP=6nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGATTGGCCCGGGCCTGGCGGCCCCCGGAACCTCAAGCCCACGGCC
AGCAAGCTGGGCGCTCCGCTGAGCGGCCTGCAGGGGCTGCCCGAGTGCACGCGCTGCGGCCACGGCATCGTGGGCACCATCGTCAAGGCA
CGGGACAAGCTCTACCATCCCGAGTGCTTCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGG
CTCTACTGTGAGAGCCACGCCAAGGCGCGCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTC
GTCTGAGCTGGGACCCTGCTCCCACGCCTGCTTCTTAAGGTCCCTGCTCGGCCGGTGTAAATATGTTTCACCCTGTCCCTCTAATAAAGC
TCCTCTGCTCCACCTTGAACCTGTCACCTGGCCTGCCACCCTCCTGCGCAGGCCATGCATGGCTCCCGAGTACAGTAGTATCTGCTTAGG
TGCCAGGCATGTCCTAGGCTCTGGGTGCAGTAGTGAGCAGGACGGGTACCATGCTGCCCTGAAGGGGGCCACAGCCTGGGTGGAAGGCAG
ACCTGAATCACAACGGGCCAGCTCTAGTAATACGAAGGTGAGGTCTGGGATGCTGCGTGCGGCGCGACGACAGGAGGTATGACCTGGGTG
GGGTCAGGGAAAGTCTTAGCTGAGAACTAAGAGATGAGGGAGGCACAAACTCTGCACGGGGGAACTGTGTGTGCAAAGGTGAGCTGGGGG
CGAGAAAGGCCTCTGTGGCCGTCATCGGCACTAGCGGGTTGGGGGTGGTGGTGGGGTGCTGGCAGCCTCAGGAGCGATCGCTCCCCTGGA
GAGGGTGATTGAGTGTGGAGATCACCGGGGCCGCCGCGGGCCGTCTGCACTTCTGTTCCAGGTTTTTCTGGCATTTTCTGTTCCAGGTTT
CTTCCACCCACGAGCACTTTATTCTCCTCCGAGACCCCCTTTTCTTCCCCTTCCTCTCTCCCCCACCAGGGGGCGCGCTTAAATTTCCAG
ACAGAGACCAGAAGGAAGGTTTAGAAAGAAAAGAACACTTGCCCAGGGCAGCTTTGCCCTCCAAGAGGCTCCCTCCTGTCTCTAAGTCAA
TTCCACCCCTCCTCGAAGTCCCGGCTTCCACCCCTCTCCTCAGAGTCCCGGCGTTTACCTCGTGGTGTGTTTGCCTTGGGCCTTTCATGC
CCCGGCTGCACACATCGTCTGTGAATTGTGGCTGTTCACTCCCGAGGATGTGTCCTAGACTCCGGGTCGCGTGGATCTACCCTCTAGTTT
ACTTGCTCGGGAGAAGAAACTGACTCGTTTTATTTAGTGCCTATTTAGCGAGCCCAGAGTAACGTACATTTGTGCTGTTTTCAATTTTGT
GCTATCGCAAATCACAAAAAAACTGTTATCAATTCACATTCATCATCAGCACGAGACCCATTTCCTTGTGCTCCTGCCAGCTCAGGATAT

>42689_42689_5_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000403231_PDLIM4_chr5_131598302_ENST00000253754_length(amino acids)=301AA_BP=2
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG
SFRYLQGMLEAGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECFMCSDCGLNLKQRGYFFLDER

--------------------------------------------------------------
>42689_42689_6_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000403231_PDLIM4_chr5_131598302_ENST00000379018_length(transcript)=891nt_BP=6nt
ATGCCGGTCCATGCTGGCAGCAAGGCTGCATTGGCTGCCCTGTGCCCAGGAGACCTGATCCAGGCCATCAATGGTGAGAGCACAGAGCTC
ATGACACACCTGGAGGCACAGAACCGCATCAAGGGCTGCCACGATCACCTCACACTGTCTGTGAGCAGGCCTGAGGGTAGGAGCTGGCCC
AGTGCCCCTGATGACAGCAAGGCTCAGGCACACAGGATCCACATCGATCCTGAGATCCAGGACGGCAGCCCAACAACCAGCAGGCGGCCC
TCAGGCACCGGGACTGGGCCAGAAGATGGCAGACCAAGCCTGGGATCTCCATATGGACAACCCCCTCGCTTTCCAGTCCCTCACAATGGC
AGCAGCGAGGCCACCCTGCCAGCCCAGATGAGCACCCTGCATGTGTCTCCACCCCCCAGCGCTGACCCAGCCAGAGGCCTCCCGCGGAGC
CGGGACTGCAGAGTCGACCTGGGCTCCGAGGTGTACAGGATGCTGCGGGAGCCAGCCGAGCCCGTGGCCGCGGAGCCCAAGCAGTCAGGC
TCCTTCCGCTACTTGCAGGGCATGCTAGAGGCCGGCGAGGGCGGGGCACCATCGTCAAGGCACGGGACAAGCTCTACCATCCCGAGTGCT
TCATGTGCAGTGACTGCGGCCTGAACCTCAAGCAGCGTGGTTACTTCTTTCTGGACGAGCGGCTCTACTGTGAGAGCCACGCCAAGGCGC
GCGTGAAGCCGCCCGAGGGCTACGACGTGGTGGCGGTGTACCCCAATGCCAAGGTGGAACTCGTCTGAGCTGGGACCCTGCTCCCACGCC

>42689_42689_6_KIF3A-PDLIM4_KIF3A_chr5_132073106_ENST00000403231_PDLIM4_chr5_131598302_ENST00000379018_length(amino acids)=217AA_BP=2
MPVHAGSKAALAALCPGDLIQAINGESTELMTHLEAQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQAHRIHIDPEIQDGSPTTSRRP
SGTGTGPEDGRPSLGSPYGQPPRFPVPHNGSSEATLPAQMSTLHVSPPPSADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIF3A-PDLIM4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KIF3A-PDLIM4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KIF3A-PDLIM4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source