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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF3B-TOX2 (FusionGDB2 ID:42705)

Fusion Gene Summary for KIF3B-TOX2

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF3B-TOX2
Fusion gene ID: 42705
HgeneTgene
Gene symbol

KIF3B

TOX2

Gene ID

9371

84969

Gene namekinesin family member 3BTOX high mobility group box family member 2
SynonymsFLA8|HH0048|KLP-11C20orf100|GCX-1|GCX1|dJ1108D11.2|dJ495O3.1
Cytomap

20q11.21

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionkinesin-like protein KIF3Bmicrotubule plus end-directed kinesin motor 3BTOX high mobility group box family member 2granulosa cell HMG box 1
Modification date2020031320200313
UniProtAcc

O15066

.
Ensembl transtripts involved in fusion geneENST00000375712, ENST00000418717, 
ENST00000358131, ENST00000372999, 
ENST00000423191, ENST00000435864, 
ENST00000341197, 
Fusion gene scores* DoF score14 X 8 X 7=78411 X 9 X 8=792
# samples 1714
** MAII scorelog2(17/784*10)=-2.20531890797751
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/792*10)=-2.50007360313464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF3B [Title/Abstract] AND TOX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF3B(30898984)-TOX2(42602007), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTOX2

GO:0045944

positive regulation of transcription by RNA polymerase II

25352127


check buttonFusion gene breakpoints across KIF3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TOX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6625-01AKIF3Bchr20

30898984

-TOX2chr20

42602007

+
ChimerDB4COADTCGA-G4-6625-01AKIF3Bchr20

30898984

+TOX2chr20

42602007

+
ChimerDB4COADTCGA-G4-6625KIF3Bchr20

30898984

+TOX2chr20

42602006

+


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Fusion Gene ORF analysis for KIF3B-TOX2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000375712ENST00000358131KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-5UTRENST00000375712ENST00000358131KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-5UTRENST00000375712ENST00000372999KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-5UTRENST00000375712ENST00000372999KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-5UTRENST00000375712ENST00000423191KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-5UTRENST00000375712ENST00000423191KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-5UTRENST00000418717ENST00000358131KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-5UTRENST00000418717ENST00000358131KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-5UTRENST00000418717ENST00000372999KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-5UTRENST00000418717ENST00000372999KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-5UTRENST00000418717ENST00000423191KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-5UTRENST00000418717ENST00000423191KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-intronENST00000375712ENST00000435864KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-intronENST00000375712ENST00000435864KIF3Bchr20

30898984

+TOX2chr20

42602006

+
5CDS-intronENST00000418717ENST00000435864KIF3Bchr20

30898984

+TOX2chr20

42602007

+
5CDS-intronENST00000418717ENST00000435864KIF3Bchr20

30898984

+TOX2chr20

42602006

+
In-frameENST00000375712ENST00000341197KIF3Bchr20

30898984

+TOX2chr20

42602007

+
In-frameENST00000375712ENST00000341197KIF3Bchr20

30898984

+TOX2chr20

42602006

+
In-frameENST00000418717ENST00000341197KIF3Bchr20

30898984

+TOX2chr20

42602007

+
In-frameENST00000418717ENST00000341197KIF3Bchr20

30898984

+TOX2chr20

42602006

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375712KIF3Bchr2030898984+ENST00000341197TOX2chr2042602007+332415711462992948
ENST00000418717KIF3Bchr2030898984+ENST00000341197TOX2chr2042602007+225950681927639
ENST00000375712KIF3Bchr2030898984+ENST00000341197TOX2chr2042602006+332415711462992948
ENST00000418717KIF3Bchr2030898984+ENST00000341197TOX2chr2042602006+225950681927639

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375712ENST00000341197KIF3Bchr2030898984+TOX2chr2042602007+0.0055047190.9944952
ENST00000418717ENST00000341197KIF3Bchr2030898984+TOX2chr2042602007+0.0232405550.9767594
ENST00000375712ENST00000341197KIF3Bchr2030898984+TOX2chr2042602006+0.0055047190.9944952
ENST00000418717ENST00000341197KIF3Bchr2030898984+TOX2chr2042602006+0.0232405550.9767594

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Fusion Genomic Features for KIF3B-TOX2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIF3Bchr2030898984+TOX2chr2042602006+4.80E-101
KIF3Bchr2030898984+TOX2chr2042602006+4.80E-101
KIF3Bchr2030898984+TOX2chr2042602006+4.80E-101
KIF3Bchr2030898984+TOX2chr2042602006+4.80E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KIF3B-TOX2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30898984/chr20:42602007)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF3B

O15066

.
FUNCTION: Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+29386_393468748.0Compositional biasNote=Poly-Gly
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+29394_406468748.0Compositional biasNote=Poly-Glu
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+29386_393468748.0Compositional biasNote=Poly-Gly
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+29394_406468748.0Compositional biasNote=Poly-Glu
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+299_340468748.0DomainKinesin motor
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+299_340468748.0DomainKinesin motor
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+2996_103468748.0Nucleotide bindingATP
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+2996_103468748.0Nucleotide bindingATP
TgeneTOX2chr20:30898984chr20:42602006ENST0000034119709245_25033507.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602006ENST0000034119709372_45633507.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602006ENST0000035813108245_25042489.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602006ENST0000035813108372_45642489.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602006ENST00000372999110245_2500465.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602006ENST00000372999110372_4560465.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602006ENST0000042319109245_2500465.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602006ENST0000042319109372_4560465.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602007ENST0000034119709245_25033507.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602007ENST0000034119709372_45633507.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602007ENST0000035813108245_25042489.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602007ENST0000035813108372_45642489.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602007ENST00000372999110245_2500465.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602007ENST00000372999110372_4560465.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602007ENST0000042319109245_2500465.0Compositional biasNote=Poly-Lys
TgeneTOX2chr20:30898984chr20:42602007ENST0000042319109372_4560465.0Compositional biasNote=Pro-rich
TgeneTOX2chr20:30898984chr20:42602006ENST0000034119709255_32333507.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602006ENST0000035813108255_32342489.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602006ENST00000372999110255_3230465.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602006ENST0000042319109255_3230465.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602007ENST0000034119709255_32333507.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602007ENST0000035813108255_32342489.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602007ENST00000372999110255_3230465.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602007ENST0000042319109255_3230465.0DNA bindingHMG box
TgeneTOX2chr20:30898984chr20:42602006ENST0000034119709223_25233507.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602006ENST0000035813108223_25242489.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602006ENST00000372999110223_2520465.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602006ENST0000042319109223_2520465.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602007ENST0000034119709223_25233507.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602007ENST0000035813108223_25242489.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602007ENST00000372999110223_2520465.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602007ENST0000042319109223_2520465.0MotifNuclear localization signal
TgeneTOX2chr20:30898984chr20:42602006ENST000003411970976_11433507.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602006ENST000003581310876_11442489.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602006ENST0000037299911076_1140465.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602006ENST000004231910976_1140465.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602007ENST000003411970976_11433507.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602007ENST000003581310876_11442489.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602007ENST0000037299911076_1140465.0RegionRequired for transcriptional activation
TgeneTOX2chr20:30898984chr20:42602007ENST000004231910976_1140465.0RegionRequired for transcriptional activation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+29346_579468748.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+29346_579468748.0Coiled coilOntology_term=ECO:0000255
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+29723_730468748.0Compositional biasNote=Poly-Ser
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+29723_730468748.0Compositional biasNote=Poly-Ser
HgeneKIF3Bchr20:30898984chr20:42602006ENST00000375712+29580_747468748.0RegionNote=Globular
HgeneKIF3Bchr20:30898984chr20:42602007ENST00000375712+29580_747468748.0RegionNote=Globular


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Fusion Gene Sequence for KIF3B-TOX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42705_42705_1_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000375712_TOX2_chr20_42602006_ENST00000341197_length(transcript)=3324nt_BP=1571nt
ATCCGGGGCAGCGGGGAATGGCTGAGCCAGGGGTTCGCCGCCCCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCCGCTTTCGG
CTCGGGCCTCAGGACCGTAGCATCCTGAGACATTTTGAATTGACACTTCTCAAGATTTGACTGGATCAGAGTTCATCATGTCAAAGTTGA
AAAGCTCAGAGTCAGTCAGGGTGGTGGTTCGCTGTCGGCCCATGAATGGCAAGGAAAAGGCTGCTTCGTATGACAAAGTGGTGGATGTGG
ATGTTAAGCTGGGGCAGGTGTCTGTGAAGAACCCCAAAGGGACGGCCCATGAAATGCCCAAGACCTTCACCTTTGATGCCGTCTATGACT
GGAATGCCAAGCAGTTTGAACTGTACGATGAGACGTTCCGACCACTTGTTGACTCTGTCCTGCAAGGTTTCAATGGAACCATTTTTGCCT
ATGGACAAACTGGGACAGGAAAAACCTACACCATGGAAGGAATCCGTGGTGACCCTGAAAAAAGAGGAGTCATTCCTAACTCATTTGACC
ATATCTTCACCCACATCTCTCGATCCCAGAATCAACAATACCTGGTCAGGGCTTCTTACTTAGAGATCTACCAGGAGGAGATCCGAGATT
TGCTCTCAAAGGATCAGACCAAAAGGCTTGAGCTCAAAGAGAGGCCTGACACAGGAGTGTATGTGAAAGACCTGTCTTCCTTTGTCACCA
AGAGTGTGAAGGAGATAGAGCATGTGATGAATGTGGGGAACCAGAACCGTTCTGTCGGTGCTACCAACATGAACGAGCACAGCTCGCGTT
CTCATGCAATTTTCGTTATCACTATTGAGTGCAGCGAGGTGGGCCTCGATGGTGAAAACCACATCCGTGTAGGAAAATTGAACCTTGTAG
ATCTTGCTGGCAGCGAACGGCAAGCCAAGACCGGCGCACAAGGGGAGAGATTAAAAGAAGCTACCAAGATCAACCTCTCCCTTTCCGCTT
TGGGTAATGTCATCTCTGCTCTAGTGGACGGCAAAAGCACTCACATTCCATATCGGGACTCAAAGCTTACCAGGCTCCTCCAAGATTCCC
TTGGTGGCAATGCCAAGACTGTGATGGTGGCCAACGTGGGGCCTGCCTCTTACAACGTAGAAGAGACTCTGACCACTCTGCGATATGCCA
ACCGTGCCAAAAACATTAAGAACAAACCAAGGGTCAATGAGGACCCCAAGGATGCCCTCCTTCGAGAATTCCAGGAAGAGATTGCTCGGC
TCAAGGCCCAGCTGGAAAAACGGTCCATTGGTAGGAGGAAGAGGCGAGAGAAGCGGAGGGAAGGTGGTGGCAGTGGTGGGGGTGGGGAAG
AGGAGGAGGAGGAGGGAGAAGAGGGTGAGGAGGAAGGGGATGATAAGGATGATTACTGGCGGGAACAGCAAGAAAAACTGGAGATTGAGA
AGCGGGCCATTGTAGAGGATCACAGCTTGGTTGCAGAGGAGAAGATGAGGCTGCTGAAGGAGAAAGAGAAAAAGATGGAGGACCTGCGGC
GGGAGAAGGATGCTGCCGAGATGCTGGGCGCCAAGATCAAGTTTGATGGTGACAGTGCCTACGTGGGGATGAGTGACGGAAACCCAGAGC
TCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACACCTCCCAACCTCCCGGAGC
CATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTCTGCTCCCTGCCTACTCCT
ATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCCAGCTGCCCACGATCCAGG
AGATGGTCCACTCGGAAGTGGCTGCCTATGACTCGGGCCGGCCCGGGCCCCTGCTGGGTCGCCCGGCAATGCTGGCCAGCCACATGAGTG
CCCTCAGCCAGTCCCAGCTCATCTCGCAGATGGGCATCCGGAGCAGCATCGCCCACAGCTCCCCATCACCGCCGGGGAGCAAGTCAGCGA
CCCCCTCTCCCTCCAGCTCCACTCAGGAAGAGGAGTCGGAAGTGCATTTCAAGATCTCGGGAGAAAAGAGACCTTCAGCCGACCCAGGAA
AAAAGGCCAAGAACCCGAAGAAGAAGAAAAAGAAGGACCCCAATGAGCCGCAGAAGCCTGTGTCGGCCTACGCACTCTTCTTCAGAGACA
CTCAGGCCGCCATCAAGGGTCAGAACCCCAGTGCCACTTTCGGTGACGTGTCCAAAATCGTGGCCTCCATGTGGGACAGCCTGGGAGAGG
AACAGAAGCAGGCCTACAAGAGGAAGACAGAAGCAGCAAAGAAGGAATATCTGAAGGCCCTGGCAGCCTACCGGGCTAGCCTCGTCTCCA
AGAGCTCCCCAGATCAAGGTGAGACCAAGAGCACTCAGGCAAACCCACCAGCCAAAATGCTCCCACCCAAGCAGCCCATGTATGCCATGC
CAGGCCTGGCCTCCTTCCTGACGCCGTCGGACCTGCAGGCCTTCCGCAGTGGGGCCTCCCCTGCCAGCCTCGCCCGGACGCTGGGCTCCA
AGTCTCTGCTGCCAGGCCTCAGTGCGTCCCCGCCGCCGCCACCCTCCTTCCCGCTCAGCCCCACACTGCACCAGCAGCTGTCACTGCCCC
CTCACGCCCAGGGCGCCCTCCTCAGTCCACCTGTTAGCATGTCCCCAGCCCCCCAGCCCCCTGTCCTGCCCACCCCCATGGCACTCCAGG
TGCAGCTGGCGATGAGCCCCTCACCTCCAGGGCCACAGGACTTCCCGCACATCTCTGAGTTCCCCAGCAGCTCGGGATCCTGCTCACCTG
GCCCATCCAACCCCACCAGCAGCGGGGACTGGGACAGCAGCTACCCCAGTGGGGAGTGTGGCATCAGCACCTGCAGCCTGCTCCCCAGGG
ACAAATCGCTCTACCTCACCTAATCCCGCCTCCCTACCATCCCTGAGGCTCGCTGGAAGGCACTGCTCAGAGCCTGAAGGGCTGACAGCA
GAAAAGAGGCCCTGGCCAGAGGCAGGGTGGCCCATCGGAGAGAGCAGTGACACACCCATTGCCCGGGGGCTGAGTCTCTTCCTCAACCTC
CCACCAGACTCTGCAGAGGCAGCCCACTGCCCACCACCAGCCCAAAGAACCTGCAGGAACCTTCCGCCCGCTGACCTGCTTGCTCCAGGG

>42705_42705_1_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000375712_TOX2_chr20_42602006_ENST00000341197_length(amino acids)=948AA_BP=475
MTGSEFIMSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDS
VLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTG
VYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLK
EATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDA
LLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLL
KEKEKKMEDLRREKDAAEMLGAKIKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHG
LTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAH
SSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSK
IVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGA
SPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHIS

--------------------------------------------------------------
>42705_42705_2_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000375712_TOX2_chr20_42602007_ENST00000341197_length(transcript)=3324nt_BP=1571nt
ATCCGGGGCAGCGGGGAATGGCTGAGCCAGGGGTTCGCCGCCCCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCCGCTTTCGG
CTCGGGCCTCAGGACCGTAGCATCCTGAGACATTTTGAATTGACACTTCTCAAGATTTGACTGGATCAGAGTTCATCATGTCAAAGTTGA
AAAGCTCAGAGTCAGTCAGGGTGGTGGTTCGCTGTCGGCCCATGAATGGCAAGGAAAAGGCTGCTTCGTATGACAAAGTGGTGGATGTGG
ATGTTAAGCTGGGGCAGGTGTCTGTGAAGAACCCCAAAGGGACGGCCCATGAAATGCCCAAGACCTTCACCTTTGATGCCGTCTATGACT
GGAATGCCAAGCAGTTTGAACTGTACGATGAGACGTTCCGACCACTTGTTGACTCTGTCCTGCAAGGTTTCAATGGAACCATTTTTGCCT
ATGGACAAACTGGGACAGGAAAAACCTACACCATGGAAGGAATCCGTGGTGACCCTGAAAAAAGAGGAGTCATTCCTAACTCATTTGACC
ATATCTTCACCCACATCTCTCGATCCCAGAATCAACAATACCTGGTCAGGGCTTCTTACTTAGAGATCTACCAGGAGGAGATCCGAGATT
TGCTCTCAAAGGATCAGACCAAAAGGCTTGAGCTCAAAGAGAGGCCTGACACAGGAGTGTATGTGAAAGACCTGTCTTCCTTTGTCACCA
AGAGTGTGAAGGAGATAGAGCATGTGATGAATGTGGGGAACCAGAACCGTTCTGTCGGTGCTACCAACATGAACGAGCACAGCTCGCGTT
CTCATGCAATTTTCGTTATCACTATTGAGTGCAGCGAGGTGGGCCTCGATGGTGAAAACCACATCCGTGTAGGAAAATTGAACCTTGTAG
ATCTTGCTGGCAGCGAACGGCAAGCCAAGACCGGCGCACAAGGGGAGAGATTAAAAGAAGCTACCAAGATCAACCTCTCCCTTTCCGCTT
TGGGTAATGTCATCTCTGCTCTAGTGGACGGCAAAAGCACTCACATTCCATATCGGGACTCAAAGCTTACCAGGCTCCTCCAAGATTCCC
TTGGTGGCAATGCCAAGACTGTGATGGTGGCCAACGTGGGGCCTGCCTCTTACAACGTAGAAGAGACTCTGACCACTCTGCGATATGCCA
ACCGTGCCAAAAACATTAAGAACAAACCAAGGGTCAATGAGGACCCCAAGGATGCCCTCCTTCGAGAATTCCAGGAAGAGATTGCTCGGC
TCAAGGCCCAGCTGGAAAAACGGTCCATTGGTAGGAGGAAGAGGCGAGAGAAGCGGAGGGAAGGTGGTGGCAGTGGTGGGGGTGGGGAAG
AGGAGGAGGAGGAGGGAGAAGAGGGTGAGGAGGAAGGGGATGATAAGGATGATTACTGGCGGGAACAGCAAGAAAAACTGGAGATTGAGA
AGCGGGCCATTGTAGAGGATCACAGCTTGGTTGCAGAGGAGAAGATGAGGCTGCTGAAGGAGAAAGAGAAAAAGATGGAGGACCTGCGGC
GGGAGAAGGATGCTGCCGAGATGCTGGGCGCCAAGATCAAGTTTGATGGTGACAGTGCCTACGTGGGGATGAGTGACGGAAACCCAGAGC
TCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACACCTCCCAACCTCCCGGAGC
CATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTCTGCTCCCTGCCTACTCCT
ATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCCAGCTGCCCACGATCCAGG
AGATGGTCCACTCGGAAGTGGCTGCCTATGACTCGGGCCGGCCCGGGCCCCTGCTGGGTCGCCCGGCAATGCTGGCCAGCCACATGAGTG
CCCTCAGCCAGTCCCAGCTCATCTCGCAGATGGGCATCCGGAGCAGCATCGCCCACAGCTCCCCATCACCGCCGGGGAGCAAGTCAGCGA
CCCCCTCTCCCTCCAGCTCCACTCAGGAAGAGGAGTCGGAAGTGCATTTCAAGATCTCGGGAGAAAAGAGACCTTCAGCCGACCCAGGAA
AAAAGGCCAAGAACCCGAAGAAGAAGAAAAAGAAGGACCCCAATGAGCCGCAGAAGCCTGTGTCGGCCTACGCACTCTTCTTCAGAGACA
CTCAGGCCGCCATCAAGGGTCAGAACCCCAGTGCCACTTTCGGTGACGTGTCCAAAATCGTGGCCTCCATGTGGGACAGCCTGGGAGAGG
AACAGAAGCAGGCCTACAAGAGGAAGACAGAAGCAGCAAAGAAGGAATATCTGAAGGCCCTGGCAGCCTACCGGGCTAGCCTCGTCTCCA
AGAGCTCCCCAGATCAAGGTGAGACCAAGAGCACTCAGGCAAACCCACCAGCCAAAATGCTCCCACCCAAGCAGCCCATGTATGCCATGC
CAGGCCTGGCCTCCTTCCTGACGCCGTCGGACCTGCAGGCCTTCCGCAGTGGGGCCTCCCCTGCCAGCCTCGCCCGGACGCTGGGCTCCA
AGTCTCTGCTGCCAGGCCTCAGTGCGTCCCCGCCGCCGCCACCCTCCTTCCCGCTCAGCCCCACACTGCACCAGCAGCTGTCACTGCCCC
CTCACGCCCAGGGCGCCCTCCTCAGTCCACCTGTTAGCATGTCCCCAGCCCCCCAGCCCCCTGTCCTGCCCACCCCCATGGCACTCCAGG
TGCAGCTGGCGATGAGCCCCTCACCTCCAGGGCCACAGGACTTCCCGCACATCTCTGAGTTCCCCAGCAGCTCGGGATCCTGCTCACCTG
GCCCATCCAACCCCACCAGCAGCGGGGACTGGGACAGCAGCTACCCCAGTGGGGAGTGTGGCATCAGCACCTGCAGCCTGCTCCCCAGGG
ACAAATCGCTCTACCTCACCTAATCCCGCCTCCCTACCATCCCTGAGGCTCGCTGGAAGGCACTGCTCAGAGCCTGAAGGGCTGACAGCA
GAAAAGAGGCCCTGGCCAGAGGCAGGGTGGCCCATCGGAGAGAGCAGTGACACACCCATTGCCCGGGGGCTGAGTCTCTTCCTCAACCTC
CCACCAGACTCTGCAGAGGCAGCCCACTGCCCACCACCAGCCCAAAGAACCTGCAGGAACCTTCCGCCCGCTGACCTGCTTGCTCCAGGG

>42705_42705_2_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000375712_TOX2_chr20_42602007_ENST00000341197_length(amino acids)=948AA_BP=475
MTGSEFIMSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDS
VLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTG
VYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLK
EATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDA
LLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLL
KEKEKKMEDLRREKDAAEMLGAKIKFDGDSAYVGMSDGNPELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHG
LTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAH
SSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSADPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSK
IVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGA
SPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLSLPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHIS

--------------------------------------------------------------
>42705_42705_3_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000418717_TOX2_chr20_42602006_ENST00000341197_length(transcript)=2259nt_BP=506nt
TAGGAAAATTGAACCTTGTAGATCTTGCTGGCAGCGAACGGCAAGCCAAGACCGGCGCACAAGGGGAGAGATTAAAAGAAGCTACCAAGA
TCAACCTCTCCCTTTCCGCTTTGGGTAATGTCATCTCTGCTCTAGTGGACGGCAAAAGCACTCACATTCCATATCGGGACTCAAAGCTTA
CCAGGCTCCTCCAAGATTCCCTTGGTGGCAATGCCAAGACTGTGATGGTGGCCAACGTGGGGCCTGCCTCTTACAACGTAGAAGAGACTC
TGACCACTCTGCGATATGCCAACCGTGCCAAAAACATTAAGAACAAACCAAGGGTCAATGAGGACCCCAAGGATGCCCTCCTTCGAGAAT
TCCAGGAAGAGATTGCTCGGCTCAAGGCCCAGCTGGAAAAACGGTCCATTGAGGAGAAGATGAGGCTGCTGAAGGAGAAAGAGAAAAAGA
TGGAGGACCTGCGGCGGGAGAAGGATGCTGCCGAGATGCTGGGCGCCAAGATCAAGTTTGATGGTGACAGTGCCTACGTGGGGATGAGTG
ACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACACCTC
CCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTCTGC
TCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCCAGC
TGCCCACGATCCAGGAGATGGTCCACTCGGAAGTGGCTGCCTATGACTCGGGCCGGCCCGGGCCCCTGCTGGGTCGCCCGGCAATGCTGG
CCAGCCACATGAGTGCCCTCAGCCAGTCCCAGCTCATCTCGCAGATGGGCATCCGGAGCAGCATCGCCCACAGCTCCCCATCACCGCCGG
GGAGCAAGTCAGCGACCCCCTCTCCCTCCAGCTCCACTCAGGAAGAGGAGTCGGAAGTGCATTTCAAGATCTCGGGAGAAAAGAGACCTT
CAGCCGACCCAGGAAAAAAGGCCAAGAACCCGAAGAAGAAGAAAAAGAAGGACCCCAATGAGCCGCAGAAGCCTGTGTCGGCCTACGCAC
TCTTCTTCAGAGACACTCAGGCCGCCATCAAGGGTCAGAACCCCAGTGCCACTTTCGGTGACGTGTCCAAAATCGTGGCCTCCATGTGGG
ACAGCCTGGGAGAGGAACAGAAGCAGGCCTACAAGAGGAAGACAGAAGCAGCAAAGAAGGAATATCTGAAGGCCCTGGCAGCCTACCGGG
CTAGCCTCGTCTCCAAGAGCTCCCCAGATCAAGGTGAGACCAAGAGCACTCAGGCAAACCCACCAGCCAAAATGCTCCCACCCAAGCAGC
CCATGTATGCCATGCCAGGCCTGGCCTCCTTCCTGACGCCGTCGGACCTGCAGGCCTTCCGCAGTGGGGCCTCCCCTGCCAGCCTCGCCC
GGACGCTGGGCTCCAAGTCTCTGCTGCCAGGCCTCAGTGCGTCCCCGCCGCCGCCACCCTCCTTCCCGCTCAGCCCCACACTGCACCAGC
AGCTGTCACTGCCCCCTCACGCCCAGGGCGCCCTCCTCAGTCCACCTGTTAGCATGTCCCCAGCCCCCCAGCCCCCTGTCCTGCCCACCC
CCATGGCACTCCAGGTGCAGCTGGCGATGAGCCCCTCACCTCCAGGGCCACAGGACTTCCCGCACATCTCTGAGTTCCCCAGCAGCTCGG
GATCCTGCTCACCTGGCCCATCCAACCCCACCAGCAGCGGGGACTGGGACAGCAGCTACCCCAGTGGGGAGTGTGGCATCAGCACCTGCA
GCCTGCTCCCCAGGGACAAATCGCTCTACCTCACCTAATCCCGCCTCCCTACCATCCCTGAGGCTCGCTGGAAGGCACTGCTCAGAGCCT
GAAGGGCTGACAGCAGAAAAGAGGCCCTGGCCAGAGGCAGGGTGGCCCATCGGAGAGAGCAGTGACACACCCATTGCCCGGGGGCTGAGT
CTCTTCCTCAACCTCCCACCAGACTCTGCAGAGGCAGCCCACTGCCCACCACCAGCCCAAAGAACCTGCAGGAACCTTCCGCCCGCTGAC
CTGCTTGCTCCAGGGTAACTGTGGACCCTGTCCTCGCCCTGCGCACGGTACCCTATGTCTGGACACCCGGCCCCAGCTCCAGCCCCAGCC

>42705_42705_3_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000418717_TOX2_chr20_42602006_ENST00000341197_length(amino acids)=639AA_BP=166
MNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTT
LRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKFDGDSAYVGMSDGN
PELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPT
IQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSAD
PGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASL
VSKSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLS
LPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLL

--------------------------------------------------------------
>42705_42705_4_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000418717_TOX2_chr20_42602007_ENST00000341197_length(transcript)=2259nt_BP=506nt
TAGGAAAATTGAACCTTGTAGATCTTGCTGGCAGCGAACGGCAAGCCAAGACCGGCGCACAAGGGGAGAGATTAAAAGAAGCTACCAAGA
TCAACCTCTCCCTTTCCGCTTTGGGTAATGTCATCTCTGCTCTAGTGGACGGCAAAAGCACTCACATTCCATATCGGGACTCAAAGCTTA
CCAGGCTCCTCCAAGATTCCCTTGGTGGCAATGCCAAGACTGTGATGGTGGCCAACGTGGGGCCTGCCTCTTACAACGTAGAAGAGACTC
TGACCACTCTGCGATATGCCAACCGTGCCAAAAACATTAAGAACAAACCAAGGGTCAATGAGGACCCCAAGGATGCCCTCCTTCGAGAAT
TCCAGGAAGAGATTGCTCGGCTCAAGGCCCAGCTGGAAAAACGGTCCATTGAGGAGAAGATGAGGCTGCTGAAGGAGAAAGAGAAAAAGA
TGGAGGACCTGCGGCGGGAGAAGGATGCTGCCGAGATGCTGGGCGCCAAGATCAAGTTTGATGGTGACAGTGCCTACGTGGGGATGAGTG
ACGGAAACCCAGAGCTCCTGTCAACCAGCCAGACCTACAACGGCCAGAGCGAGAACAACGAAGACTATGAGATCCCCCCGATAACACCTC
CCAACCTCCCGGAGCCATCCCTCCTGCACCTGGGGGACCACGAAGCCAGCTACCACTCGCTGTGCCACGGCCTCACCCCCAACGGTCTGC
TCCCTGCCTACTCCTATCAGGCCATGGACCTCCCAGCCATCATGGTGTCCAACATGCTAGCACAGGACAGCCACCTGCTGTCGGGCCAGC
TGCCCACGATCCAGGAGATGGTCCACTCGGAAGTGGCTGCCTATGACTCGGGCCGGCCCGGGCCCCTGCTGGGTCGCCCGGCAATGCTGG
CCAGCCACATGAGTGCCCTCAGCCAGTCCCAGCTCATCTCGCAGATGGGCATCCGGAGCAGCATCGCCCACAGCTCCCCATCACCGCCGG
GGAGCAAGTCAGCGACCCCCTCTCCCTCCAGCTCCACTCAGGAAGAGGAGTCGGAAGTGCATTTCAAGATCTCGGGAGAAAAGAGACCTT
CAGCCGACCCAGGAAAAAAGGCCAAGAACCCGAAGAAGAAGAAAAAGAAGGACCCCAATGAGCCGCAGAAGCCTGTGTCGGCCTACGCAC
TCTTCTTCAGAGACACTCAGGCCGCCATCAAGGGTCAGAACCCCAGTGCCACTTTCGGTGACGTGTCCAAAATCGTGGCCTCCATGTGGG
ACAGCCTGGGAGAGGAACAGAAGCAGGCCTACAAGAGGAAGACAGAAGCAGCAAAGAAGGAATATCTGAAGGCCCTGGCAGCCTACCGGG
CTAGCCTCGTCTCCAAGAGCTCCCCAGATCAAGGTGAGACCAAGAGCACTCAGGCAAACCCACCAGCCAAAATGCTCCCACCCAAGCAGC
CCATGTATGCCATGCCAGGCCTGGCCTCCTTCCTGACGCCGTCGGACCTGCAGGCCTTCCGCAGTGGGGCCTCCCCTGCCAGCCTCGCCC
GGACGCTGGGCTCCAAGTCTCTGCTGCCAGGCCTCAGTGCGTCCCCGCCGCCGCCACCCTCCTTCCCGCTCAGCCCCACACTGCACCAGC
AGCTGTCACTGCCCCCTCACGCCCAGGGCGCCCTCCTCAGTCCACCTGTTAGCATGTCCCCAGCCCCCCAGCCCCCTGTCCTGCCCACCC
CCATGGCACTCCAGGTGCAGCTGGCGATGAGCCCCTCACCTCCAGGGCCACAGGACTTCCCGCACATCTCTGAGTTCCCCAGCAGCTCGG
GATCCTGCTCACCTGGCCCATCCAACCCCACCAGCAGCGGGGACTGGGACAGCAGCTACCCCAGTGGGGAGTGTGGCATCAGCACCTGCA
GCCTGCTCCCCAGGGACAAATCGCTCTACCTCACCTAATCCCGCCTCCCTACCATCCCTGAGGCTCGCTGGAAGGCACTGCTCAGAGCCT
GAAGGGCTGACAGCAGAAAAGAGGCCCTGGCCAGAGGCAGGGTGGCCCATCGGAGAGAGCAGTGACACACCCATTGCCCGGGGGCTGAGT
CTCTTCCTCAACCTCCCACCAGACTCTGCAGAGGCAGCCCACTGCCCACCACCAGCCCAAAGAACCTGCAGGAACCTTCCGCCCGCTGAC
CTGCTTGCTCCAGGGTAACTGTGGACCCTGTCCTCGCCCTGCGCACGGTACCCTATGTCTGGACACCCGGCCCCAGCTCCAGCCCCAGCC

>42705_42705_4_KIF3B-TOX2_KIF3B_chr20_30898984_ENST00000418717_TOX2_chr20_42602007_ENST00000341197_length(amino acids)=639AA_BP=166
MNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTT
LRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKFDGDSAYVGMSDGN
PELLSTSQTYNGQSENNEDYEIPPITPPNLPEPSLLHLGDHEASYHSLCHGLTPNGLLPAYSYQAMDLPAIMVSNMLAQDSHLLSGQLPT
IQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGIRSSIAHSSPSPPGSKSATPSPSSSTQEEESEVHFKISGEKRPSAD
PGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASL
VSKSSPDQGETKSTQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSGASPASLARTLGSKSLLPGLSASPPPPPSFPLSPTLHQQLS
LPPHAQGALLSPPVSMSPAPQPPVLPTPMALQVQLAMSPSPPGPQDFPHISEFPSSSGSCSPGPSNPTSSGDWDSSYPSGECGISTCSLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KIF3B-TOX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF3B-TOX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF3B-TOX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource