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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KIF5C-GULP1 (FusionGDB2 ID:42738)

Fusion Gene Summary for KIF5C-GULP1

check button Fusion gene summary
Fusion gene informationFusion gene name: KIF5C-GULP1
Fusion gene ID: 42738
HgeneTgene
Gene symbol

KIF5C

GULP1

Gene ID

3800

51454

Gene namekinesin family member 5CGULP PTB domain containing engulfment adaptor 1
SynonymsCDCBM2|KINN|NKHC|NKHC-2|NKHC2CED-6|CED6|GULP
Cytomap

2q23.1-q23.2

2q32.1-q32.2

Type of geneprotein-codingprotein-coding
Descriptionkinesin heavy chain isoform 5Ckinesin heavy chainkinesin heavy chain neuron-specific 2PTB domain-containing engulfment adapter protein 1GULP, engulfment adaptor PTB domain containing 1PTB domain adapter protein CED-6PTB domain adaptor protein CED-6cell death protein 6 homologengulfment adapter protein
Modification date2020031320200313
UniProtAcc

O60282

Q9UBP9

Ensembl transtripts involved in fusion geneENST00000397413, ENST00000414838, 
ENST00000435030, ENST00000464066, 
ENST00000409830, ENST00000409843, 
ENST00000359135, ENST00000409580, 
ENST00000409609, ENST00000409637, 
ENST00000409805, ENST00000410051, 
ENST00000479019, 
Fusion gene scores* DoF score8 X 7 X 5=28010 X 12 X 6=720
# samples 810
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/720*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KIF5C [Title/Abstract] AND GULP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIF5C(149868197)-GULP1(189458667), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGULP1

GO:0006911

phagocytosis, engulfment

11729193


check buttonFusion gene breakpoints across KIF5C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GULP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2O-01AKIF5Cchr2

149868197

-GULP1chr2

189458667

+
ChimerDB4SARCTCGA-DX-AB2O-01AKIF5Cchr2

149868197

+GULP1chr2

189458667

+


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Fusion Gene ORF analysis for KIF5C-GULP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000397413ENST00000409830KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000397413ENST00000409843KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000414838ENST00000409830KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000414838ENST00000409843KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000435030ENST00000409830KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000435030ENST00000409843KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000464066ENST00000409830KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-3CDSENST00000464066ENST00000409843KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000359135KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000409580KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000409609KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000409637KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000409805KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000410051KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000397413ENST00000479019KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000359135KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000409580KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000409609KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000409637KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000409805KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000410051KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000414838ENST00000479019KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000359135KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000409580KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000409609KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000409637KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000409805KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000410051KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000435030ENST00000479019KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000359135KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000409580KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000409609KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000409637KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000409805KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000410051KIF5Cchr2

149868197

+GULP1chr2

189458667

+
3UTR-intronENST00000464066ENST00000479019KIF5Cchr2

149868197

+GULP1chr2

189458667

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KIF5C-GULP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KIF5Cchr2149868197+GULP1chr2189458666+5.44E-050.99994564
KIF5Cchr2149868197+GULP1chr2189458666+5.44E-050.99994564

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KIF5C-GULP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:149868197/:189458667)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF5C

O60282

GULP1

Q9UBP9

FUNCTION: Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:P28738, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:24812067}.FUNCTION: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for KIF5C-GULP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KIF5C-GULP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KIF5C-GULP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KIF5C-GULP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource