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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KIRREL-CD1C (FusionGDB2 ID:42786)

Fusion Gene Summary for KIRREL-CD1C

Fusion gene summary

Fusion gene information	Fusion gene name: KIRREL-CD1C
	Fusion gene ID: 42786
		Hgene	Tgene
	Gene symbol	KIRREL	CD1C
	Gene ID	55243	911
	Gene name	kirre like nephrin family adhesion molecule 1	CD1c molecule
	Synonyms	KIRREL\|NEPH1	BDCA1\|CD1\|CD1A\|R7
	Cytomap	1q23.1	1q23.1
	Type of gene	protein-coding	protein-coding
	Description	kin of IRRE-like protein 1kin of IRRE likekin of irregular chiasm-like protein 1nephrin relatednephrin-like protein 1	T-cell surface glycoprotein CD1cCD1C antigen, c polypeptidecortical thymocyte antigen CD1Cdifferentiation antigen CD1-alpha-3
	Modification date	20200313	20200313
	UniProtAcc	.	P29017
	Ensembl transtripts involved in fusion gene	ENST00000360089, ENST00000359209, ENST00000368173, ENST00000392272, ENST00000416935, ENST00000368172,	ENST00000368170,
Fusion gene scores	* DoF score	11 X 5 X 6=330	4 X 1 X 3=12
	# samples	13	4
	** MAII score	log2(13/330*10)=-1.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KIRREL [Title/Abstract] AND CD1C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KIRREL(157963518)-CD1C(158260924), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CD1C	GO:0002286	T cell activation involved in immune response	21167756

Fusion gene breakpoints across KIRREL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CD1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-7710	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
ChimerDB4	SARC	TCGA-DX-AB2O-01A	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
ChimerDB4	SARC	TCGA-DX-AB2V-01A	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+

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Fusion Gene ORF analysis for KIRREL-CD1C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000360089	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
In-frame	ENST00000359209	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
In-frame	ENST00000368173	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
In-frame	ENST00000392272	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
In-frame	ENST00000416935	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+
intron-3CDS	ENST00000368172	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000392272

KIRREL

chr1

157963518

ENST00000368170

CD1C

chr1

158260924

1551

456

404

1396

330

ENST00000368173

KIRREL

chr1

157963518

ENST00000368170

CD1C

chr1

158260924

1551

456

404

1396

330

ENST00000359209

KIRREL

chr1

157963518

ENST00000368170

CD1C

chr1

158260924

1214

119

1059

330

ENST00000416935

KIRREL

chr1

157963518

ENST00000368170

CD1C

chr1

158260924

1179

1024

330

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392272	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+	0.020694649	0.9793053
ENST00000368173	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+	0.020694649	0.9793053
ENST00000359209	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+	0.023271658	0.9767284
ENST00000416935	ENST00000368170	KIRREL	chr1	157963518	+	CD1C	chr1	158260924	+	0.020308461	0.97969157

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Fusion Genomic Features for KIRREL-CD1C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KIRREL	chr1	157963522	+	CD1C	chr1	158260923	+	0.9240832	0.075916864
KIRREL	chr1	157963522	+	CD1C	chr1	158260923	+	0.9240832	0.075916864
KIRREL	chr1	157963522	+	CD1C	chr1	158260923	+	0.9240832	0.075916864
KIRREL	chr1	157963522	+	CD1C	chr1	158260923	+	0.9240832	0.075916864

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KIRREL-CD1C

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:157963518/chr1:158260924)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CD1C P29017
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269\|PubMed:10786796, ECO:0000269\|PubMed:10890914, ECO:0000269\|PubMed:10899914, ECO:0000269\|PubMed:21167756}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CD1C

chr1:157963518

chr1:158260924

ENST00000368170

206_296

334.0

Domain

Note=Ig-like

Tgene

CD1C

chr1:157963518

chr1:158260924

ENST00000368170

329_332

334.0

Motif

Note=Internalization signal

Tgene

CD1C

chr1:157963518

chr1:158260924

ENST00000368170

18_302

334.0

Topological domain

Extracellular

Tgene

CD1C

chr1:157963518

chr1:158260924

ENST00000368170

324_333

334.0

Topological domain

Cytoplasmic

Tgene

CD1C

chr1:157963518

chr1:158260924

ENST00000368170

303_323

334.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

120_216

758.0

Domain

Note=Ig-like C2-type 2

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

21_115

758.0

Domain

Note=Ig-like C2-type 1

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

223_299

758.0

Domain

Note=Ig-like C2-type 3

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

308_387

758.0

Domain

Note=Ig-like C2-type 4

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

392_488

758.0

Domain

Note=Ig-like C2-type 5

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

120_216

774.0

Domain

Note=Ig-like C2-type 2

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

21_115

774.0

Domain

Note=Ig-like C2-type 1

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

223_299

774.0

Domain

Note=Ig-like C2-type 3

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

308_387

774.0

Domain

Note=Ig-like C2-type 4

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

392_488

774.0

Domain

Note=Ig-like C2-type 5

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

120_216

655.0

Domain

Note=Ig-like C2-type 2

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

21_115

655.0

Domain

Note=Ig-like C2-type 1

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

223_299

655.0

Domain

Note=Ig-like C2-type 3

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

308_387

655.0

Domain

Note=Ig-like C2-type 4

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

392_488

655.0

Domain

Note=Ig-like C2-type 5

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

405_407

758.0

Motif

Cell attachment site

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

405_407

774.0

Motif

Cell attachment site

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

405_407

655.0

Motif

Cell attachment site

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

17_499

758.0

Topological domain

Extracellular

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

521_757

758.0

Topological domain

Cytoplasmic

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

17_499

774.0

Topological domain

Extracellular

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

521_757

774.0

Topological domain

Cytoplasmic

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

17_499

655.0

Topological domain

Extracellular

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

521_757

655.0

Topological domain

Cytoplasmic

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000359209

500_520

758.0

Transmembrane

Helical

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000368173

500_520

774.0

Transmembrane

Helical

Hgene

KIRREL

chr1:157963518

chr1:158260924

ENST00000392272

500_520

655.0

Transmembrane

Helical

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Fusion Gene Sequence for KIRREL-CD1C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42786_42786_1_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000359209_CD1C_chr1_158260924_ENST00000368170_length(transcript)=1214nt_BP=119nt
CCGCTCCTCTGGCTCGCTCGCCAACTCCGGGCCCCAGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGAT
CCTCACTCTCTCCGATACTTTCTCCCAAGCATCCCAGGAACACGTCTCCTTCCATGTCATCCAGATCTTCTCATTTGTCAACCAATCCTG
GGCACGAGGTCAGGGCTCAGGATGGCTGGACGAGTTGCAGACTCATGGCTGGGACAGTGAATCAGGCACAATAATTTTCCTGCATAACTG
GTCCAAGGGCAACTTCAGCAATGAAGAGTTGTCAGACCTAGAGTTGTTATTTCGTTTCTACCTCTTTGGATTAACTCGGGAGATTCAAGA
CCATGCAAGTCAAGATTACTCGAAATATCCCTTTGAAGTACAGGTGAAAGCGGGCTGTGAGCTGCATTCTGGAAAGAGCCCAGAAGGCTT
CTTTCAGGTAGCTTTCAACGGATTAGATTTACTGAGTTTCCAGAATACAACATGGGTGCCATCTCCAGGCTGTGGAAGTTTGGCCCAAAG
TGTCTGTCATCTACTCAATCATCAGTATGAAGGCGTCACAGAAACAGTGTATAATCTCATAAGAAGCACTTGCCCCCGATTTCTCTTGGG
TCTCCTGGATGCAGGGAAGATGTATGTACACAGGCAAGTGAGGCCAGAAGCCTGGCTGTCCAGTCGCCCCAGCCTTGGGTCTGGCCAGCT
GTTGCTGGTTTGTCATGCCTCCGGCTTCTACCCAAAGCCTGTTTGGGTGACATGGATGCGGAATGAACAGGAGCAACTGGGCACTAAACA
TGGTGATATTCTTCCTAATGCTGATGGGACATGGTATCTTCAGGTGATCCTGGAGGTGGCATCTGAGGAGCCTGCTGGCCTGTCTTGTCG
AGTGAGACACAGCAGTCTAGGAGGCCAGGACATCATCCTCTACTGGGGACACCACTTTTCCATGAATTGGATTGCCTTGGTAGTGATAGT
GCCCTTGGTGATTCTAATAGTCCTTGTGTTATGGTTTAAGAAGCACTGCTCATATCAGGACATCCTGTGAGACTCTTCCCCCTGACTCCC
CCATTGTGTTAAGAACCCAGCAACCCAGGAGCCTAGTACAATATAGTGATGCCATCCCGTCGACTCTCCATTTAAATTGTTTCTCTTTCT

>42786_42786_1_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000359209_CD1C_chr1_158260924_ENST00000368170_length(amino acids)=330AA_BP=0
MLSLLVWILTLSDTFSQASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLF
GLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRS
TCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASE

--------------------------------------------------------------
>42786_42786_2_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000368173_CD1C_chr1_158260924_ENST00000368170_length(transcript)=1551nt_BP=456nt
GGCGCCGTCGGAGGGAGAGTAGACGTCAGGCGGAGGGAGGGAGGCAGGCAGGCAGGGAGGCAGGGAGGGAGAGAGGGAAGGAAGAGAAGG
GGAGAGAAAGGGGGAGCAAAGACCGAAAGAGACCCAGAGAGATACAGCTTGAGAGGAGAAATAATTAAAGGGGGAGGGCGACCAGGAGGA
GAAAAAGGTCTGGGAGGAAAGAGAGATAAAGAGAATCGGAGGGCAGGGAAATGAGTTTGTGCGCGTGAGTGTGCGCGCGCGCGTGTGTGT
GTGCAGGGGCGGGCGCGGGCGGGCGGGGGGCGGGCTCCCGGGCTCCCGGGCTCCCCTCCTCCCCAGCCCGCTCCTCTGGCTCGCTCGCCA
ACTCCGGGCCCCAGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCT
CCCAAGCATCCCAGGAACACGTCTCCTTCCATGTCATCCAGATCTTCTCATTTGTCAACCAATCCTGGGCACGAGGTCAGGGCTCAGGAT
GGCTGGACGAGTTGCAGACTCATGGCTGGGACAGTGAATCAGGCACAATAATTTTCCTGCATAACTGGTCCAAGGGCAACTTCAGCAATG
AAGAGTTGTCAGACCTAGAGTTGTTATTTCGTTTCTACCTCTTTGGATTAACTCGGGAGATTCAAGACCATGCAAGTCAAGATTACTCGA
AATATCCCTTTGAAGTACAGGTGAAAGCGGGCTGTGAGCTGCATTCTGGAAAGAGCCCAGAAGGCTTCTTTCAGGTAGCTTTCAACGGAT
TAGATTTACTGAGTTTCCAGAATACAACATGGGTGCCATCTCCAGGCTGTGGAAGTTTGGCCCAAAGTGTCTGTCATCTACTCAATCATC
AGTATGAAGGCGTCACAGAAACAGTGTATAATCTCATAAGAAGCACTTGCCCCCGATTTCTCTTGGGTCTCCTGGATGCAGGGAAGATGT
ATGTACACAGGCAAGTGAGGCCAGAAGCCTGGCTGTCCAGTCGCCCCAGCCTTGGGTCTGGCCAGCTGTTGCTGGTTTGTCATGCCTCCG
GCTTCTACCCAAAGCCTGTTTGGGTGACATGGATGCGGAATGAACAGGAGCAACTGGGCACTAAACATGGTGATATTCTTCCTAATGCTG
ATGGGACATGGTATCTTCAGGTGATCCTGGAGGTGGCATCTGAGGAGCCTGCTGGCCTGTCTTGTCGAGTGAGACACAGCAGTCTAGGAG
GCCAGGACATCATCCTCTACTGGGGACACCACTTTTCCATGAATTGGATTGCCTTGGTAGTGATAGTGCCCTTGGTGATTCTAATAGTCC
TTGTGTTATGGTTTAAGAAGCACTGCTCATATCAGGACATCCTGTGAGACTCTTCCCCCTGACTCCCCCATTGTGTTAAGAACCCAGCAA
CCCAGGAGCCTAGTACAATATAGTGATGCCATCCCGTCGACTCTCCATTTAAATTGTTTCTCTTTCTGCATAATAAACATTTGTTAATAA

>42786_42786_2_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000368173_CD1C_chr1_158260924_ENST00000368170_length(amino acids)=330AA_BP=0
MLSLLVWILTLSDTFSQASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLF
GLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRS
TCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASE

--------------------------------------------------------------
>42786_42786_3_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000392272_CD1C_chr1_158260924_ENST00000368170_length(transcript)=1551nt_BP=456nt
GGCGCCGTCGGAGGGAGAGTAGACGTCAGGCGGAGGGAGGGAGGCAGGCAGGCAGGGAGGCAGGGAGGGAGAGAGGGAAGGAAGAGAAGG
GGAGAGAAAGGGGGAGCAAAGACCGAAAGAGACCCAGAGAGATACAGCTTGAGAGGAGAAATAATTAAAGGGGGAGGGCGACCAGGAGGA
GAAAAAGGTCTGGGAGGAAAGAGAGATAAAGAGAATCGGAGGGCAGGGAAATGAGTTTGTGCGCGTGAGTGTGCGCGCGCGCGTGTGTGT
GTGCAGGGGCGGGCGCGGGCGGGCGGGGGGCGGGCTCCCGGGCTCCCGGGCTCCCCTCCTCCCCAGCCCGCTCCTCTGGCTCGCTCGCCA
ACTCCGGGCCCCAGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCT
CCCAAGCATCCCAGGAACACGTCTCCTTCCATGTCATCCAGATCTTCTCATTTGTCAACCAATCCTGGGCACGAGGTCAGGGCTCAGGAT
GGCTGGACGAGTTGCAGACTCATGGCTGGGACAGTGAATCAGGCACAATAATTTTCCTGCATAACTGGTCCAAGGGCAACTTCAGCAATG
AAGAGTTGTCAGACCTAGAGTTGTTATTTCGTTTCTACCTCTTTGGATTAACTCGGGAGATTCAAGACCATGCAAGTCAAGATTACTCGA
AATATCCCTTTGAAGTACAGGTGAAAGCGGGCTGTGAGCTGCATTCTGGAAAGAGCCCAGAAGGCTTCTTTCAGGTAGCTTTCAACGGAT
TAGATTTACTGAGTTTCCAGAATACAACATGGGTGCCATCTCCAGGCTGTGGAAGTTTGGCCCAAAGTGTCTGTCATCTACTCAATCATC
AGTATGAAGGCGTCACAGAAACAGTGTATAATCTCATAAGAAGCACTTGCCCCCGATTTCTCTTGGGTCTCCTGGATGCAGGGAAGATGT
ATGTACACAGGCAAGTGAGGCCAGAAGCCTGGCTGTCCAGTCGCCCCAGCCTTGGGTCTGGCCAGCTGTTGCTGGTTTGTCATGCCTCCG
GCTTCTACCCAAAGCCTGTTTGGGTGACATGGATGCGGAATGAACAGGAGCAACTGGGCACTAAACATGGTGATATTCTTCCTAATGCTG
ATGGGACATGGTATCTTCAGGTGATCCTGGAGGTGGCATCTGAGGAGCCTGCTGGCCTGTCTTGTCGAGTGAGACACAGCAGTCTAGGAG
GCCAGGACATCATCCTCTACTGGGGACACCACTTTTCCATGAATTGGATTGCCTTGGTAGTGATAGTGCCCTTGGTGATTCTAATAGTCC
TTGTGTTATGGTTTAAGAAGCACTGCTCATATCAGGACATCCTGTGAGACTCTTCCCCCTGACTCCCCCATTGTGTTAAGAACCCAGCAA
CCCAGGAGCCTAGTACAATATAGTGATGCCATCCCGTCGACTCTCCATTTAAATTGTTTCTCTTTCTGCATAATAAACATTTGTTAATAA

>42786_42786_3_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000392272_CD1C_chr1_158260924_ENST00000368170_length(amino acids)=330AA_BP=0
MLSLLVWILTLSDTFSQASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLF
GLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRS
TCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASE

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>42786_42786_4_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000416935_CD1C_chr1_158260924_ENST00000368170_length(transcript)=1179nt_BP=84nt
AGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGCATCCC
AGGAACACGTCTCCTTCCATGTCATCCAGATCTTCTCATTTGTCAACCAATCCTGGGCACGAGGTCAGGGCTCAGGATGGCTGGACGAGT
TGCAGACTCATGGCTGGGACAGTGAATCAGGCACAATAATTTTCCTGCATAACTGGTCCAAGGGCAACTTCAGCAATGAAGAGTTGTCAG
ACCTAGAGTTGTTATTTCGTTTCTACCTCTTTGGATTAACTCGGGAGATTCAAGACCATGCAAGTCAAGATTACTCGAAATATCCCTTTG
AAGTACAGGTGAAAGCGGGCTGTGAGCTGCATTCTGGAAAGAGCCCAGAAGGCTTCTTTCAGGTAGCTTTCAACGGATTAGATTTACTGA
GTTTCCAGAATACAACATGGGTGCCATCTCCAGGCTGTGGAAGTTTGGCCCAAAGTGTCTGTCATCTACTCAATCATCAGTATGAAGGCG
TCACAGAAACAGTGTATAATCTCATAAGAAGCACTTGCCCCCGATTTCTCTTGGGTCTCCTGGATGCAGGGAAGATGTATGTACACAGGC
AAGTGAGGCCAGAAGCCTGGCTGTCCAGTCGCCCCAGCCTTGGGTCTGGCCAGCTGTTGCTGGTTTGTCATGCCTCCGGCTTCTACCCAA
AGCCTGTTTGGGTGACATGGATGCGGAATGAACAGGAGCAACTGGGCACTAAACATGGTGATATTCTTCCTAATGCTGATGGGACATGGT
ATCTTCAGGTGATCCTGGAGGTGGCATCTGAGGAGCCTGCTGGCCTGTCTTGTCGAGTGAGACACAGCAGTCTAGGAGGCCAGGACATCA
TCCTCTACTGGGGACACCACTTTTCCATGAATTGGATTGCCTTGGTAGTGATAGTGCCCTTGGTGATTCTAATAGTCCTTGTGTTATGGT
TTAAGAAGCACTGCTCATATCAGGACATCCTGTGAGACTCTTCCCCCTGACTCCCCCATTGTGTTAAGAACCCAGCAACCCAGGAGCCTA
GTACAATATAGTGATGCCATCCCGTCGACTCTCCATTTAAATTGTTTCTCTTTCTGCATAATAAACATTTGTTAATAAAAACCAAATTCT

>42786_42786_4_KIRREL-CD1C_KIRREL_chr1_157963518_ENST00000416935_CD1C_chr1_158260924_ENST00000368170_length(amino acids)=330AA_BP=0
MLSLLVWILTLSDTFSQASQEHVSFHVIQIFSFVNQSWARGQGSGWLDELQTHGWDSESGTIIFLHNWSKGNFSNEELSDLELLFRFYLF
GLTREIQDHASQDYSKYPFEVQVKAGCELHSGKSPEGFFQVAFNGLDLLSFQNTTWVPSPGCGSLAQSVCHLLNHQYEGVTETVYNLIRS
TCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPVWVTWMRNEQEQLGTKHGDILPNADGTWYLQVILEVASE

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Fusion Gene PPI Analysis for KIRREL-CD1C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KIRREL-CD1C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KIRREL-CD1C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source