FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KIRREL-CD48 (FusionGDB2 ID:42787)

Fusion Gene Summary for KIRREL-CD48

check button Fusion gene summary
Fusion gene informationFusion gene name: KIRREL-CD48
Fusion gene ID: 42787
HgeneTgene
Gene symbol

KIRREL

CD48

Gene ID

55243

962

Gene namekirre like nephrin family adhesion molecule 1CD48 molecule
SynonymsKIRREL|NEPH1BCM1|BLAST|BLAST1|MEM-102|SLAMF2|hCD48|mCD48
Cytomap

1q23.1

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionkin of IRRE-like protein 1kin of IRRE likekin of irregular chiasm-like protein 1nephrin relatednephrin-like protein 1CD48 antigenB-lymphocyte activation marker BLAST-1BCM1 surface antigenCD48 antigen (B-cell membrane protein)SLAM family member 2TCT.1leukocyte antigen MEM-102signaling lymphocytic activation molecule 2
Modification date2020031320200313
UniProtAcc.

P09326

Ensembl transtripts involved in fusion geneENST00000360089, ENST00000359209, 
ENST00000368173, ENST00000392272, 
ENST00000416935, ENST00000368172, 
ENST00000368045, ENST00000368046, 
Fusion gene scores* DoF score11 X 5 X 6=3304 X 2 X 3=24
# samples 134
** MAII scorelog2(13/330*10)=-1.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KIRREL [Title/Abstract] AND CD48 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKIRREL(157963518)-CD48(160654979), # samples:2
Anticipated loss of major functional domain due to fusion event.KIRREL-CD48 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KIRREL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CD48 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FR-A3YN-06AKIRRELchr1

157963518

-CD48chr1

160654979

-
ChimerDB4SKCMTCGA-FR-A3YN-06AKIRRELchr1

157963518

+CD48chr1

160654979

-


Top

Fusion Gene ORF analysis for KIRREL-CD48

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000360089ENST00000368045KIRRELchr1

157963518

+CD48chr1

160654979

-
5UTR-3CDSENST00000360089ENST00000368046KIRRELchr1

157963518

+CD48chr1

160654979

-
Frame-shiftENST00000359209ENST00000368045KIRRELchr1

157963518

+CD48chr1

160654979

-
Frame-shiftENST00000368173ENST00000368045KIRRELchr1

157963518

+CD48chr1

160654979

-
Frame-shiftENST00000392272ENST00000368045KIRRELchr1

157963518

+CD48chr1

160654979

-
Frame-shiftENST00000416935ENST00000368045KIRRELchr1

157963518

+CD48chr1

160654979

-
In-frameENST00000359209ENST00000368046KIRRELchr1

157963518

+CD48chr1

160654979

-
In-frameENST00000368173ENST00000368046KIRRELchr1

157963518

+CD48chr1

160654979

-
In-frameENST00000392272ENST00000368046KIRRELchr1

157963518

+CD48chr1

160654979

-
In-frameENST00000416935ENST00000368046KIRRELchr1

157963518

+CD48chr1

160654979

-
intron-3CDSENST00000368172ENST00000368045KIRRELchr1

157963518

+CD48chr1

160654979

-
intron-3CDSENST00000368172ENST00000368046KIRRELchr1

157963518

+CD48chr1

160654979

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392272KIRRELchr1157963518+ENST00000368046CD48chr1160654979-14124564041105233
ENST00000368173KIRRELchr1157963518+ENST00000368046CD48chr1160654979-14124564041105233
ENST00000359209KIRRELchr1157963518+ENST00000368046CD48chr1160654979-107511967768233
ENST00000416935KIRRELchr1157963518+ENST00000368046CD48chr1160654979-10408432733233

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392272ENST00000368046KIRRELchr1157963518+CD48chr1160654979-0.0062326060.9937674
ENST00000368173ENST00000368046KIRRELchr1157963518+CD48chr1160654979-0.0062326060.9937674
ENST00000359209ENST00000368046KIRRELchr1157963518+CD48chr1160654979-0.0032070850.99679285
ENST00000416935ENST00000368046KIRRELchr1157963518+CD48chr1160654979-0.0027359140.99726415

Top

Fusion Genomic Features for KIRREL-CD48


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KIRREL-CD48


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:157963518/chr1:160654979)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CD48

P09326

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD48chr1:157963518chr1:160654979ENST0000036804604132_21227244.0DomainNote=Ig-like C2-type 2
TgeneCD48chr1:157963518chr1:160654979ENST000003680460429_12727244.0DomainNote=Ig-like C2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115120_21617758.0DomainNote=Ig-like C2-type 2
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+11521_11517758.0DomainNote=Ig-like C2-type 1
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115223_29917758.0DomainNote=Ig-like C2-type 3
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115308_38717758.0DomainNote=Ig-like C2-type 4
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115392_48817758.0DomainNote=Ig-like C2-type 5
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115120_21617774.0DomainNote=Ig-like C2-type 2
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+11521_11517774.0DomainNote=Ig-like C2-type 1
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115223_29917774.0DomainNote=Ig-like C2-type 3
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115308_38717774.0DomainNote=Ig-like C2-type 4
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115392_48817774.0DomainNote=Ig-like C2-type 5
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113120_21617655.0DomainNote=Ig-like C2-type 2
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+11321_11517655.0DomainNote=Ig-like C2-type 1
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113223_29917655.0DomainNote=Ig-like C2-type 3
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113308_38717655.0DomainNote=Ig-like C2-type 4
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113392_48817655.0DomainNote=Ig-like C2-type 5
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115405_40717758.0MotifCell attachment site
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115405_40717774.0MotifCell attachment site
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113405_40717655.0MotifCell attachment site
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+11517_49917758.0Topological domainExtracellular
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115521_75717758.0Topological domainCytoplasmic
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+11517_49917774.0Topological domainExtracellular
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115521_75717774.0Topological domainCytoplasmic
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+11317_49917655.0Topological domainExtracellular
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113521_75717655.0Topological domainCytoplasmic
HgeneKIRRELchr1:157963518chr1:160654979ENST00000359209+115500_52017758.0TransmembraneHelical
HgeneKIRRELchr1:157963518chr1:160654979ENST00000368173+115500_52017774.0TransmembraneHelical
HgeneKIRRELchr1:157963518chr1:160654979ENST00000392272+113500_52017655.0TransmembraneHelical


Top

Fusion Gene Sequence for KIRREL-CD48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42787_42787_1_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000359209_CD48_chr1_160654979_ENST00000368046_length(transcript)=1075nt_BP=119nt
CCGCTCCTCTGGCTCGCTCGCCAACTCCGGGCCCCAGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGAT
CCTCACTCTCTCCGATACTTTCTCCCAAGGTCACTTGGTACATATGACCGTGGTCTCCGGCAGCAACGTGACTCTGAACATCTCTGAGAG
CCTGCCTGAGAACTACAAACAACTAACCTGGTTTTATACTTTCGACCAGAAGATTGTAGAATGGGATTCCAGAAAATCTAAGTACTTTGA
ATCCAAATTTAAAGGCAGGGTCAGACTTGATCCTCAGAGTGGCGCACTGTACATCTCTAAGGTCCAGAAAGAGGACAACAGCACCTACAT
CATGAGGGTGTTGAAAAAGACTGGGAATGAGCAAGAATGGAAGATCAAGCTGCAAGTGCTTGACCCTGTACCCAAGCCTGTCATCAAAAT
TGAGAAGATAGAAGACATGGATGACAACTGTTATCTGAAACTGTCATGTGTGATACCTGGCGAGTCTGTAAACTACACCTGGTATGGGGA
CAAAAGGCCCTTCCCAAAGGAGCTCCAGAACAGTGTGCTTGAAACCACCCTTATGCCACATAATTACTCCAGGTGTTATACTTGCCAAGT
CAGCAATTCTGTGAGCAGCAAGAATGGCACGGTCTGCCTCAGTCCACCCTGTACCCTGGCCCGGTCCTTTGGAGTAGAATGGATTGCAAG
TTGGCTAGTGGTCACGGTGCCCACCATTCTTGGCCTGTTACTTACCTGAGATGAGCTCTTTTAACTCAAGCGAAACTTCAAGGCCAGAAG
ATCTTGCCTGTTGGTGATCATGCTCCTCACCAGGACAGAGACTGTATAGGCTGACCAGAAGCATGCTGCTGAATTATCAACGAGGATTTT
CAAGTTAACTTTTAAATACTGGTTATTATTTAATTTTATATCCCTTTGTTGTTTTCTAGTACACAGAGATATAGAGATACACATGCTTTT

>42787_42787_1_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000359209_CD48_chr1_160654979_ENST00000368046_length(amino acids)=233AA_BP=17
MLSLLVWILTLSDTFSQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQ
KEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNY

--------------------------------------------------------------
>42787_42787_2_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000368173_CD48_chr1_160654979_ENST00000368046_length(transcript)=1412nt_BP=456nt
GGCGCCGTCGGAGGGAGAGTAGACGTCAGGCGGAGGGAGGGAGGCAGGCAGGCAGGGAGGCAGGGAGGGAGAGAGGGAAGGAAGAGAAGG
GGAGAGAAAGGGGGAGCAAAGACCGAAAGAGACCCAGAGAGATACAGCTTGAGAGGAGAAATAATTAAAGGGGGAGGGCGACCAGGAGGA
GAAAAAGGTCTGGGAGGAAAGAGAGATAAAGAGAATCGGAGGGCAGGGAAATGAGTTTGTGCGCGTGAGTGTGCGCGCGCGCGTGTGTGT
GTGCAGGGGCGGGCGCGGGCGGGCGGGGGGCGGGCTCCCGGGCTCCCGGGCTCCCCTCCTCCCCAGCCCGCTCCTCTGGCTCGCTCGCCA
ACTCCGGGCCCCAGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCT
CCCAAGGTCACTTGGTACATATGACCGTGGTCTCCGGCAGCAACGTGACTCTGAACATCTCTGAGAGCCTGCCTGAGAACTACAAACAAC
TAACCTGGTTTTATACTTTCGACCAGAAGATTGTAGAATGGGATTCCAGAAAATCTAAGTACTTTGAATCCAAATTTAAAGGCAGGGTCA
GACTTGATCCTCAGAGTGGCGCACTGTACATCTCTAAGGTCCAGAAAGAGGACAACAGCACCTACATCATGAGGGTGTTGAAAAAGACTG
GGAATGAGCAAGAATGGAAGATCAAGCTGCAAGTGCTTGACCCTGTACCCAAGCCTGTCATCAAAATTGAGAAGATAGAAGACATGGATG
ACAACTGTTATCTGAAACTGTCATGTGTGATACCTGGCGAGTCTGTAAACTACACCTGGTATGGGGACAAAAGGCCCTTCCCAAAGGAGC
TCCAGAACAGTGTGCTTGAAACCACCCTTATGCCACATAATTACTCCAGGTGTTATACTTGCCAAGTCAGCAATTCTGTGAGCAGCAAGA
ATGGCACGGTCTGCCTCAGTCCACCCTGTACCCTGGCCCGGTCCTTTGGAGTAGAATGGATTGCAAGTTGGCTAGTGGTCACGGTGCCCA
CCATTCTTGGCCTGTTACTTACCTGAGATGAGCTCTTTTAACTCAAGCGAAACTTCAAGGCCAGAAGATCTTGCCTGTTGGTGATCATGC
TCCTCACCAGGACAGAGACTGTATAGGCTGACCAGAAGCATGCTGCTGAATTATCAACGAGGATTTTCAAGTTAACTTTTAAATACTGGT
TATTATTTAATTTTATATCCCTTTGTTGTTTTCTAGTACACAGAGATATAGAGATACACATGCTTTTTTCCCACCCAAAATTGTGACAAC

>42787_42787_2_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000368173_CD48_chr1_160654979_ENST00000368046_length(amino acids)=233AA_BP=17
MLSLLVWILTLSDTFSQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQ
KEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNY

--------------------------------------------------------------
>42787_42787_3_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000392272_CD48_chr1_160654979_ENST00000368046_length(transcript)=1412nt_BP=456nt
GGCGCCGTCGGAGGGAGAGTAGACGTCAGGCGGAGGGAGGGAGGCAGGCAGGCAGGGAGGCAGGGAGGGAGAGAGGGAAGGAAGAGAAGG
GGAGAGAAAGGGGGAGCAAAGACCGAAAGAGACCCAGAGAGATACAGCTTGAGAGGAGAAATAATTAAAGGGGGAGGGCGACCAGGAGGA
GAAAAAGGTCTGGGAGGAAAGAGAGATAAAGAGAATCGGAGGGCAGGGAAATGAGTTTGTGCGCGTGAGTGTGCGCGCGCGCGTGTGTGT
GTGCAGGGGCGGGCGCGGGCGGGCGGGGGGCGGGCTCCCGGGCTCCCGGGCTCCCCTCCTCCCCAGCCCGCTCCTCTGGCTCGCTCGCCA
ACTCCGGGCCCCAGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCT
CCCAAGGTCACTTGGTACATATGACCGTGGTCTCCGGCAGCAACGTGACTCTGAACATCTCTGAGAGCCTGCCTGAGAACTACAAACAAC
TAACCTGGTTTTATACTTTCGACCAGAAGATTGTAGAATGGGATTCCAGAAAATCTAAGTACTTTGAATCCAAATTTAAAGGCAGGGTCA
GACTTGATCCTCAGAGTGGCGCACTGTACATCTCTAAGGTCCAGAAAGAGGACAACAGCACCTACATCATGAGGGTGTTGAAAAAGACTG
GGAATGAGCAAGAATGGAAGATCAAGCTGCAAGTGCTTGACCCTGTACCCAAGCCTGTCATCAAAATTGAGAAGATAGAAGACATGGATG
ACAACTGTTATCTGAAACTGTCATGTGTGATACCTGGCGAGTCTGTAAACTACACCTGGTATGGGGACAAAAGGCCCTTCCCAAAGGAGC
TCCAGAACAGTGTGCTTGAAACCACCCTTATGCCACATAATTACTCCAGGTGTTATACTTGCCAAGTCAGCAATTCTGTGAGCAGCAAGA
ATGGCACGGTCTGCCTCAGTCCACCCTGTACCCTGGCCCGGTCCTTTGGAGTAGAATGGATTGCAAGTTGGCTAGTGGTCACGGTGCCCA
CCATTCTTGGCCTGTTACTTACCTGAGATGAGCTCTTTTAACTCAAGCGAAACTTCAAGGCCAGAAGATCTTGCCTGTTGGTGATCATGC
TCCTCACCAGGACAGAGACTGTATAGGCTGACCAGAAGCATGCTGCTGAATTATCAACGAGGATTTTCAAGTTAACTTTTAAATACTGGT
TATTATTTAATTTTATATCCCTTTGTTGTTTTCTAGTACACAGAGATATAGAGATACACATGCTTTTTTCCCACCCAAAATTGTGACAAC

>42787_42787_3_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000392272_CD48_chr1_160654979_ENST00000368046_length(amino acids)=233AA_BP=17
MLSLLVWILTLSDTFSQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQ
KEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNY

--------------------------------------------------------------
>42787_42787_4_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000416935_CD48_chr1_160654979_ENST00000368046_length(transcript)=1040nt_BP=84nt
AGCCGCGGGCGGGCGCACGGCGGGCGGACAGCATGCTGAGCCTCCTCGTCTGGATCCTCACTCTCTCCGATACTTTCTCCCAAGGTCACT
TGGTACATATGACCGTGGTCTCCGGCAGCAACGTGACTCTGAACATCTCTGAGAGCCTGCCTGAGAACTACAAACAACTAACCTGGTTTT
ATACTTTCGACCAGAAGATTGTAGAATGGGATTCCAGAAAATCTAAGTACTTTGAATCCAAATTTAAAGGCAGGGTCAGACTTGATCCTC
AGAGTGGCGCACTGTACATCTCTAAGGTCCAGAAAGAGGACAACAGCACCTACATCATGAGGGTGTTGAAAAAGACTGGGAATGAGCAAG
AATGGAAGATCAAGCTGCAAGTGCTTGACCCTGTACCCAAGCCTGTCATCAAAATTGAGAAGATAGAAGACATGGATGACAACTGTTATC
TGAAACTGTCATGTGTGATACCTGGCGAGTCTGTAAACTACACCTGGTATGGGGACAAAAGGCCCTTCCCAAAGGAGCTCCAGAACAGTG
TGCTTGAAACCACCCTTATGCCACATAATTACTCCAGGTGTTATACTTGCCAAGTCAGCAATTCTGTGAGCAGCAAGAATGGCACGGTCT
GCCTCAGTCCACCCTGTACCCTGGCCCGGTCCTTTGGAGTAGAATGGATTGCAAGTTGGCTAGTGGTCACGGTGCCCACCATTCTTGGCC
TGTTACTTACCTGAGATGAGCTCTTTTAACTCAAGCGAAACTTCAAGGCCAGAAGATCTTGCCTGTTGGTGATCATGCTCCTCACCAGGA
CAGAGACTGTATAGGCTGACCAGAAGCATGCTGCTGAATTATCAACGAGGATTTTCAAGTTAACTTTTAAATACTGGTTATTATTTAATT
TTATATCCCTTTGTTGTTTTCTAGTACACAGAGATATAGAGATACACATGCTTTTTTCCCACCCAAAATTGTGACAACATTATGTGAATG

>42787_42787_4_KIRREL-CD48_KIRREL_chr1_157963518_ENST00000416935_CD48_chr1_160654979_ENST00000368046_length(amino acids)=233AA_BP=17
MLSLLVWILTLSDTFSQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQ
KEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KIRREL-CD48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KIRREL-CD48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KIRREL-CD48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource