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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC16-MICU1 (FusionGDB2 ID:4281)

Fusion Gene Summary for ANAPC16-MICU1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC16-MICU1
Fusion gene ID: 4281
HgeneTgene
Gene symbol

ANAPC16

MICU1

Gene ID

119504

10367

Gene nameanaphase promoting complex subunit 16mitochondrial calcium uptake 1
SynonymsAPC16|C10orf104|CENP-27|MSAG|bA570G20.3CALC|CBARA1|EFHA3|MPXPS|ara CALC
Cytomap

10q22.1

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 16centromere protein 27cyclosome subunit 16metabolic syndrome-associated proteincalcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
Modification date2020031320200313
UniProtAcc

Q96DE5

Q9BPX6

Ensembl transtripts involved in fusion geneENST00000470481, ENST00000299381, 
ENST00000361114, ENST00000398761, 
ENST00000398763, ENST00000401998, 
ENST00000418483, ENST00000604025, 
Fusion gene scores* DoF score4 X 6 X 2=4822 X 15 X 11=3630
# samples 530
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(30/3630*10)=-3.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC16 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC16(73975830)-MICU1(74237014), # samples:2
ANAPC16(73975896)-MICU1(74237014), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC16

GO:0016567

protein ubiquitination

20360068

TgeneMICU1

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

TgeneMICU1

GO:0051260

protein homooligomerization

24514027

TgeneMICU1

GO:0051561

positive regulation of mitochondrial calcium ion concentration

24560927

TgeneMICU1

GO:0070509

calcium ion import

20693986


check buttonFusion gene breakpoints across ANAPC16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06Q-01AANAPC16chr10

73975830

+MICU1chr10

74237014

-
ChimerDB4BRCATCGA-A8-A06Q-01AANAPC16chr10

73975896

-MICU1chr10

74237014

-
ChimerDB4BRCATCGA-A8-A06Q-01AANAPC16chr10

73975896

+MICU1chr10

74237014

-
ChimerDB4BRCATCGA-A8-A06Q-01AANAPC16chr10

73980137

+MICU1chr10

74237014

-
ChimerDB4BRCATCGA-A8-A06Q-01AANAPC16chr10

73983814

+MICU1chr10

74237014

-
ChimerDB4BRCATCGA-A8-A06QANAPC16chr10

73975830

+MICU1chr10

74237014

-


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Fusion Gene ORF analysis for ANAPC16-MICU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000470481ENST00000361114ANAPC16chr10

73983814

+MICU1chr10

74237014

-
3UTR-3CDSENST00000470481ENST00000398761ANAPC16chr10

73983814

+MICU1chr10

74237014

-
3UTR-3CDSENST00000470481ENST00000398763ANAPC16chr10

73983814

+MICU1chr10

74237014

-
3UTR-3CDSENST00000470481ENST00000401998ANAPC16chr10

73983814

+MICU1chr10

74237014

-
3UTR-3CDSENST00000470481ENST00000418483ANAPC16chr10

73983814

+MICU1chr10

74237014

-
3UTR-intronENST00000470481ENST00000604025ANAPC16chr10

73983814

+MICU1chr10

74237014

-
5CDS-intronENST00000299381ENST00000604025ANAPC16chr10

73983814

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000361114ANAPC16chr10

73975896

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000361114ANAPC16chr10

73975830

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000398761ANAPC16chr10

73975896

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000398761ANAPC16chr10

73975830

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000398763ANAPC16chr10

73975896

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000398763ANAPC16chr10

73975830

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000401998ANAPC16chr10

73975896

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000401998ANAPC16chr10

73975830

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000418483ANAPC16chr10

73975896

+MICU1chr10

74237014

-
5UTR-3CDSENST00000299381ENST00000418483ANAPC16chr10

73975830

+MICU1chr10

74237014

-
5UTR-intronENST00000299381ENST00000604025ANAPC16chr10

73975896

+MICU1chr10

74237014

-
5UTR-intronENST00000299381ENST00000604025ANAPC16chr10

73975830

+MICU1chr10

74237014

-
In-frameENST00000299381ENST00000361114ANAPC16chr10

73983814

+MICU1chr10

74237014

-
In-frameENST00000299381ENST00000398761ANAPC16chr10

73983814

+MICU1chr10

74237014

-
In-frameENST00000299381ENST00000398763ANAPC16chr10

73983814

+MICU1chr10

74237014

-
In-frameENST00000299381ENST00000401998ANAPC16chr10

73983814

+MICU1chr10

74237014

-
In-frameENST00000299381ENST00000418483ANAPC16chr10

73983814

+MICU1chr10

74237014

-
intron-3CDSENST00000299381ENST00000361114ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000299381ENST00000398761ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000299381ENST00000398763ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000299381ENST00000401998ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000299381ENST00000418483ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000361114ANAPC16chr10

73975896

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000361114ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000361114ANAPC16chr10

73975830

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000398761ANAPC16chr10

73975896

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000398761ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000398761ANAPC16chr10

73975830

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000398763ANAPC16chr10

73975896

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000398763ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000398763ANAPC16chr10

73975830

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000401998ANAPC16chr10

73975896

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000401998ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000401998ANAPC16chr10

73975830

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000418483ANAPC16chr10

73975896

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000418483ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-3CDSENST00000470481ENST00000418483ANAPC16chr10

73975830

+MICU1chr10

74237014

-
intron-intronENST00000299381ENST00000604025ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-intronENST00000470481ENST00000604025ANAPC16chr10

73975896

+MICU1chr10

74237014

-
intron-intronENST00000470481ENST00000604025ANAPC16chr10

73980137

+MICU1chr10

74237014

-
intron-intronENST00000470481ENST00000604025ANAPC16chr10

73975830

+MICU1chr10

74237014

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000299381ANAPC16chr1073983814+ENST00000401998MICU1chr1074237014-18942601181038306
ENST00000299381ANAPC16chr1073983814+ENST00000361114MICU1chr1074237014-18942601181038306
ENST00000299381ANAPC16chr1073983814+ENST00000398761MICU1chr1074237014-18942601181038306
ENST00000299381ANAPC16chr1073983814+ENST00000418483MICU1chr1074237014-13202601181038306
ENST00000299381ANAPC16chr1073983814+ENST00000398763MICU1chr1074237014-11232601181038306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000299381ENST00000401998ANAPC16chr1073983814+MICU1chr1074237014-0.0027536640.9972464
ENST00000299381ENST00000361114ANAPC16chr1073983814+MICU1chr1074237014-0.0025921580.99740785
ENST00000299381ENST00000398761ANAPC16chr1073983814+MICU1chr1074237014-0.0027536640.9972464
ENST00000299381ENST00000418483ANAPC16chr1073983814+MICU1chr1074237014-0.0032897740.9967102
ENST00000299381ENST00000398763ANAPC16chr1073983814+MICU1chr1074237014-0.003655570.9963444

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Fusion Genomic Features for ANAPC16-MICU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANAPC16-MICU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:73975830/chr10:74237014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC16

Q96DE5

MICU1

Q9BPX6

FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:20360068}.FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269|PubMed:16002733, ECO:0000269|PubMed:20693986, ECO:0000269|PubMed:22904319, ECO:0000269|PubMed:23101630, ECO:0000269|PubMed:23747253, ECO:0000269|PubMed:24313810, ECO:0000269|PubMed:24332854, ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26341627, ECO:0000269|PubMed:26903221, ECO:0000269|PubMed:27099988}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANAPC16chr10:73983814chr10:74237014ENST00000299381+244_2647111.0Compositional biasNote=Ser-rich
TgeneMICU1chr10:73983814chr10:74237014ENST00000361114512231_242217477.0Calcium binding1
TgeneMICU1chr10:73983814chr10:74237014ENST00000361114512421_432217477.0Calcium binding2
TgeneMICU1chr10:73983814chr10:74237014ENST0000039876329231_24219279.0Calcium binding1
TgeneMICU1chr10:73983814chr10:74237014ENST0000039876329421_43219279.0Calcium binding2
TgeneMICU1chr10:73983814chr10:74237014ENST0000041848307231_24219279.0Calcium binding1
TgeneMICU1chr10:73983814chr10:74237014ENST0000041848307421_43219279.0Calcium binding2
TgeneMICU1chr10:73983814chr10:74237014ENST00000361114512218_253217477.0DomainEF-hand 1
TgeneMICU1chr10:73983814chr10:74237014ENST00000361114512408_443217477.0DomainEF-hand 2
TgeneMICU1chr10:73983814chr10:74237014ENST0000039876329218_25319279.0DomainEF-hand 1
TgeneMICU1chr10:73983814chr10:74237014ENST0000039876329408_44319279.0DomainEF-hand 2
TgeneMICU1chr10:73983814chr10:74237014ENST0000041848307218_25319279.0DomainEF-hand 1
TgeneMICU1chr10:73983814chr10:74237014ENST0000041848307408_44319279.0DomainEF-hand 2
TgeneMICU1chr10:73983814chr10:74237014ENST00000361114512455_465217477.0RegionC-helix region
TgeneMICU1chr10:73983814chr10:74237014ENST0000039876329455_46519279.0RegionC-helix region
TgeneMICU1chr10:73983814chr10:74237014ENST000003987632999_11019279.0RegionPolybasic region
TgeneMICU1chr10:73983814chr10:74237014ENST0000041848307455_46519279.0RegionC-helix region
TgeneMICU1chr10:73983814chr10:74237014ENST000004184830799_11019279.0RegionPolybasic region
TgeneMICU1chr10:73983814chr10:74237014ENST000003987632953_47619279.0Topological domainMitochondrial intermembrane
TgeneMICU1chr10:73983814chr10:74237014ENST000004184830753_47619279.0Topological domainMitochondrial intermembrane
TgeneMICU1chr10:73983814chr10:74237014ENST000003987632934_5219279.0TransmembraneHelical
TgeneMICU1chr10:73983814chr10:74237014ENST000004184830734_5219279.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMICU1chr10:73983814chr10:74237014ENST0000036111451299_110217477.0RegionPolybasic region
TgeneMICU1chr10:73983814chr10:74237014ENST0000036111451253_476217477.0Topological domainMitochondrial intermembrane
TgeneMICU1chr10:73983814chr10:74237014ENST0000036111451234_52217477.0TransmembraneHelical


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Fusion Gene Sequence for ANAPC16-MICU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4281_4281_1_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000361114_length(transcript)=1894nt_BP=260nt
CGAACACGCCGCGGTCCTCGTCGTGGTGAGCGCAGCCACTCAGGCTGGTCCTGGGGGTGGGGCTGTAGGGGAAAGTGCTAAAGCCGCTGA
GTGAAGTAAGAACTCTGCTAGAGAGGAAATGGCTGCTTCATCATCATCCTCCTCAGCTGGTGGGGTCAGTGGAAGTTCTGTCACTGGATC
TGGTTTCAGTGTCTCAGACCTTGCCCCACCACGGAAAGCCCTTTTCACCTACCCCAAAGGAGCTGGAGAGATGTTAGAAGCTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT
GGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTG
TCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACAT
GAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCA
CACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTG
CTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACC
CTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCT
CAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGA
CTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAG
CTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAA

>4281_4281_1_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000361114_length(amino acids)=306AA_BP=47
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEAPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRH
RDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLK
KHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------
>4281_4281_2_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000398761_length(transcript)=1894nt_BP=260nt
CGAACACGCCGCGGTCCTCGTCGTGGTGAGCGCAGCCACTCAGGCTGGTCCTGGGGGTGGGGCTGTAGGGGAAAGTGCTAAAGCCGCTGA
GTGAAGTAAGAACTCTGCTAGAGAGGAAATGGCTGCTTCATCATCATCCTCCTCAGCTGGTGGGGTCAGTGGAAGTTCTGTCACTGGATC
TGGTTTCAGTGTCTCAGACCTTGCCCCACCACGGAAAGCCCTTTTCACCTACCCCAAAGGAGCTGGAGAGATGTTAGAAGCTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT
GGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTG
TCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACAT
GAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCA
CACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTG
CTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACC
CTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCT
CAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGA
CTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAG
CTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAA

>4281_4281_2_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000398761_length(amino acids)=306AA_BP=47
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEAPQRNFEIAFKMFDLNGDGEVDMEEFEQAISIIRSQTSMGMRH
RDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLK
KHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------
>4281_4281_3_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000398763_length(transcript)=1123nt_BP=260nt
CGAACACGCCGCGGTCCTCGTCGTGGTGAGCGCAGCCACTCAGGCTGGTCCTGGGGGTGGGGCTGTAGGGGAAAGTGCTAAAGCCGCTGA
GTGAAGTAAGAACTCTGCTAGAGAGGAAATGGCTGCTTCATCATCATCCTCCTCAGCTGGTGGGGTCAGTGGAAGTTCTGTCACTGGATC
TGGTTTCAGTGTCTCAGACCTTGCCCCACCACGGAAAGCCCTTTTCACCTACCCCAAAGGAGCTGGAGAGATGTTAGAAGCTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT

>4281_4281_3_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000398763_length(amino acids)=306AA_BP=47
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEAPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRH
RDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLK
KHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------
>4281_4281_4_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000401998_length(transcript)=1894nt_BP=260nt
CGAACACGCCGCGGTCCTCGTCGTGGTGAGCGCAGCCACTCAGGCTGGTCCTGGGGGTGGGGCTGTAGGGGAAAGTGCTAAAGCCGCTGA
GTGAAGTAAGAACTCTGCTAGAGAGGAAATGGCTGCTTCATCATCATCCTCCTCAGCTGGTGGGGTCAGTGGAAGTTCTGTCACTGGATC
TGGTTTCAGTGTCTCAGACCTTGCCCCACCACGGAAAGCCCTTTTCACCTACCCCAAAGGAGCTGGAGAGATGTTAGAAGCTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT
GGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTG
TCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACAT
GAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCA
CACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTG
CTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACC
CTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCT
CAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGA
CTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAG
CTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAA

>4281_4281_4_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000401998_length(amino acids)=306AA_BP=47
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEAPQRNFEIAFKMFDLNGDGEVDMEEFEQAISIIRSQTSMGMRH
RDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLK
KHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------
>4281_4281_5_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000418483_length(transcript)=1320nt_BP=260nt
CGAACACGCCGCGGTCCTCGTCGTGGTGAGCGCAGCCACTCAGGCTGGTCCTGGGGGTGGGGCTGTAGGGGAAAGTGCTAAAGCCGCTGA
GTGAAGTAAGAACTCTGCTAGAGAGGAAATGGCTGCTTCATCATCATCCTCCTCAGCTGGTGGGGTCAGTGGAAGTTCTGTCACTGGATC
TGGTTTCAGTGTCTCAGACCTTGCCCCACCACGGAAAGCCCTTTTCACCTACCCCAAAGGAGCTGGAGAGATGTTAGAAGCTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT
GGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTG
TCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACAT

>4281_4281_5_ANAPC16-MICU1_ANAPC16_chr10_73983814_ENST00000299381_MICU1_chr10_74237014_ENST00000418483_length(amino acids)=306AA_BP=47
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEAPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRH
RDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLK
KHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANAPC16-MICU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC16-MICU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC16-MICU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource