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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLC1-KLC1 (FusionGDB2 ID:42826)

Fusion Gene Summary for KLC1-KLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: KLC1-KLC1
Fusion gene ID: 42826
HgeneTgene
Gene symbol

KLC1

KLC1

Gene ID

3831

3831

Gene namekinesin light chain 1kinesin light chain 1
SynonymsKLC|KNS2|KNS2AKLC|KNS2|KNS2A
Cytomap

14q32.33

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionkinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50kinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50
Modification date2020031320200313
UniProtAcc

Q07866

Q07866

Ensembl transtripts involved in fusion geneENST00000246489, ENST00000334553, 
ENST00000347839, ENST00000348520, 
ENST00000380038, ENST00000389744, 
ENST00000445352, ENST00000452929, 
ENST00000553286, ENST00000554280, 
ENST00000555836, ENST00000557450, 
ENST00000557575, 		ENST00000389744, 
ENST00000445352, ENST00000553286, 
ENST00000557575, ENST00000246489, 
ENST00000334553, ENST00000347839, 
ENST00000348520, ENST00000380038, 
ENST00000452929, ENST00000554280, 
ENST00000555836, ENST00000557450, 
Fusion gene scores* DoF score9 X 12 X 6=64820 X 16 X 10=3200
# samples 1622
** MAII scorelog2(16/648*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/3200*10)=-3.86249647625007
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLC1 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLC1(104145802)-KLC1(104151978), # samples:1
KLC1(104145884)-KLC1(104136518), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF950914KLC1chr14

104145884

+KLC1chr14

104136518

+
ChiTaRS5.0N/ABQ320374KLC1chr14

104145802

-KLC1chr14

104151978

-


Top

Fusion Gene ORF analysis for KLC1-KLC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000246489ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000246489ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000246489ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000246489ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000334553ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000334553ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000334553ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000334553ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000347839ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000347839ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000347839ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000347839ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000348520ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000348520ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000348520ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000348520ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000380038ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000380038ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000380038ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000380038ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000389744ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000389744ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000389744ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000389744ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000445352ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000445352ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000445352ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000445352ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000452929ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000452929ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000452929ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000452929ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000553286ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000553286ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000553286ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000553286ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000554280ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000554280ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000554280ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000554280ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000555836ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000555836ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000555836ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000555836ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557450ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557450ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557450ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557450ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557575ENST00000389744KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557575ENST00000445352KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557575ENST00000553286KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-3UTRENST00000557575ENST00000557575KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000246489ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000334553ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000347839ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000348520ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000380038ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000389744ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000445352ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000452929ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000553286ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000553286ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000553286ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000553286ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000553286ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000553286ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000553286ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000553286ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000553286ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000554280ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

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5CDS-intronENST00000554280ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000554280ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000246489KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000334553KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000347839KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000348520KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000380038KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000452929KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000554280KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000555836KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000555836ENST00000557450KLC1chr14

104145802

-KLC1chr14

104151978

-
5CDS-intronENST00000557450ENST00000246489KLC1chr14

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5CDS-intronENST00000557450ENST00000334553KLC1chr14

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5CDS-intronENST00000557450ENST00000347839KLC1chr14

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5CDS-intronENST00000557450ENST00000348520KLC1chr14

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5CDS-intronENST00000557450ENST00000380038KLC1chr14

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5CDS-intronENST00000557450ENST00000452929KLC1chr14

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5CDS-intronENST00000557450ENST00000554280KLC1chr14

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5CDS-intronENST00000557450ENST00000555836KLC1chr14

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5CDS-intronENST00000557450ENST00000557450KLC1chr14

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5CDS-intronENST00000557575ENST00000246489KLC1chr14

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5CDS-intronENST00000557575ENST00000334553KLC1chr14

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5CDS-intronENST00000557575ENST00000347839KLC1chr14

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5CDS-intronENST00000557575ENST00000348520KLC1chr14

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5CDS-intronENST00000557575ENST00000380038KLC1chr14

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5CDS-intronENST00000557575ENST00000452929KLC1chr14

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5CDS-intronENST00000557575ENST00000554280KLC1chr14

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5CDS-intronENST00000557575ENST00000555836KLC1chr14

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5CDS-intronENST00000557575ENST00000557450KLC1chr14

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In-frameENST00000334553ENST00000553286KLC1chr14

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In-frameENST00000334553ENST00000554280KLC1chr14

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In-frameENST00000452929ENST00000557450KLC1chr14

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In-frameENST00000452929ENST00000557575KLC1chr14

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In-frameENST00000553286ENST00000334553KLC1chr14

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In-frameENST00000553286ENST00000347839KLC1chr14

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In-frameENST00000553286ENST00000348520KLC1chr14

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In-frameENST00000553286ENST00000389744KLC1chr14

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In-frameENST00000553286ENST00000452929KLC1chr14

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In-frameENST00000553286ENST00000554280KLC1chr14

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In-frameENST00000553286ENST00000555836KLC1chr14

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In-frameENST00000553286ENST00000557450KLC1chr14

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In-frameENST00000557575ENST00000334553KLC1chr14

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In-frameENST00000557575ENST00000348520KLC1chr14

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In-frameENST00000557575ENST00000380038KLC1chr14

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In-frameENST00000557575ENST00000553286KLC1chr14

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intron-3CDSENST00000347839ENST00000246489KLC1chr14

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intron-3CDSENST00000347839ENST00000334553KLC1chr14

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intron-3CDSENST00000347839ENST00000347839KLC1chr14

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intron-3CDSENST00000347839ENST00000348520KLC1chr14

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intron-3CDSENST00000347839ENST00000380038KLC1chr14

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intron-3CDSENST00000347839ENST00000389744KLC1chr14

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intron-3CDSENST00000347839ENST00000445352KLC1chr14

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intron-3CDSENST00000347839ENST00000452929KLC1chr14

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intron-3CDSENST00000347839ENST00000553286KLC1chr14

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intron-3CDSENST00000347839ENST00000554280KLC1chr14

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intron-3CDSENST00000347839ENST00000555836KLC1chr14

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intron-3CDSENST00000347839ENST00000557450KLC1chr14

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intron-3CDSENST00000347839ENST00000557575KLC1chr14

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intron-3CDSENST00000380038ENST00000246489KLC1chr14

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intron-3CDSENST00000380038ENST00000334553KLC1chr14

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intron-3CDSENST00000380038ENST00000347839KLC1chr14

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intron-3CDSENST00000380038ENST00000348520KLC1chr14

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intron-3CDSENST00000380038ENST00000380038KLC1chr14

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intron-3CDSENST00000445352ENST00000554280KLC1chr14

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104136518

+
intron-3CDSENST00000557450ENST00000452929KLC1chr14

104145884

+KLC1chr14

104136518

+
intron-3CDSENST00000557450ENST00000553286KLC1chr14

104145884

+KLC1chr14

104136518

+
intron-3CDSENST00000557450ENST00000554280KLC1chr14

104145884

+KLC1chr14

104136518

+
intron-3CDSENST00000557450ENST00000555836KLC1chr14

104145884

+KLC1chr14

104136518

+
intron-3CDSENST00000557450ENST00000557450KLC1chr14

104145884

+KLC1chr14

104136518

+
intron-3CDSENST00000557450ENST00000557575KLC1chr14

104145884

+KLC1chr14

104136518

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KLC1-KLC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KLC1chr14104145882+KLC1chr14104136518+9.02E-080.9999999
KLC1chr14104145882+KLC1chr14104136518+9.02E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KLC1-KLC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:104145802/chr14:104151978)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLC1

Q07866

KLC1

Q07866

FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+131627_156550638.0Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+131727_156550668.6666666666666Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+131527_156550585.0Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+131527_156550898.3333333333334Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+131627_156550619.0Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+131427_156550561.0Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+1316213_246550638.0RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+1316255_288550638.0RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+1316297_330550638.0RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+1316339_372550638.0RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+1316381_414550638.0RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000246489+1316464_497550638.0RepeatNote=TPR 6
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+1317213_246550668.6666666666666RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+1317255_288550668.6666666666666RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+1317297_330550668.6666666666666RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+1317339_372550668.6666666666666RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+1317381_414550668.6666666666666RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000334553+1317464_497550668.6666666666666RepeatNote=TPR 6
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+1315213_246550585.0RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+1315255_288550585.0RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+1315297_330550585.0RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+1315339_372550585.0RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+1315381_414550585.0RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000348520+1315464_497550585.0RepeatNote=TPR 6
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+1315213_246550898.3333333333334RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+1315255_288550898.3333333333334RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+1315297_330550898.3333333333334RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+1315339_372550898.3333333333334RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+1315381_414550898.3333333333334RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000389744+1315464_497550898.3333333333334RepeatNote=TPR 6
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+1316213_246550619.0RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+1316255_288550619.0RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+1316297_330550619.0RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+1316339_372550619.0RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+1316381_414550619.0RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000452929+1316464_497550619.0RepeatNote=TPR 6
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+1314213_246550561.0RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+1314255_288550561.0RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+1314297_330550561.0RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+1314339_372550561.0RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+1314381_414550561.0RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000553286+1314464_497550561.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000246489516297_330295638.0RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000246489516339_372295638.0RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000246489516381_414295638.0RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000246489516464_497295638.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000334553517297_330295668.6666666666666RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000334553517339_372295668.6666666666666RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000334553517381_414295668.6666666666666RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000334553517464_497295668.6666666666666RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000347839516297_330295629.0RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000347839516339_372295629.0RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000347839516381_414295629.0RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000347839516464_497295629.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000348520515297_330295585.0RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000348520515339_372295585.0RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000348520515381_414295585.0RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000348520515464_497295585.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000389744515297_330295898.3333333333334RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000389744515339_372295898.3333333333334RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000389744515381_414295898.3333333333334RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000389744515464_497295898.3333333333334RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000452929516297_330295619.0RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000452929516339_372295619.0RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000452929516381_414295619.0RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000452929516464_497295619.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000553286514297_330295561.0RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000553286514339_372295561.0RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000553286514381_414295561.0RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000553286514464_497295561.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST00000557450515297_330295585.0RepeatNote=TPR 3
TgeneKLC1chr14:104145884chr14:104136518ENST00000557450515339_372295585.0RepeatNote=TPR 4
TgeneKLC1chr14:104145884chr14:104136518ENST00000557450515381_414295585.0RepeatNote=TPR 5
TgeneKLC1chr14:104145884chr14:104136518ENST00000557450515464_497295585.0RepeatNote=TPR 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+11627_1560629.0Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+11527_1560585.0Coiled coil.
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+116213_2460629.0RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+116255_2880629.0RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+116297_3300629.0RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+116339_3720629.0RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+116381_4140629.0RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000347839+116464_4970629.0RepeatNote=TPR 6
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+115213_2460585.0RepeatNote=TPR 1
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+115255_2880585.0RepeatNote=TPR 2
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+115297_3300585.0RepeatNote=TPR 3
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+115339_3720585.0RepeatNote=TPR 4
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+115381_4140585.0RepeatNote=TPR 5
HgeneKLC1chr14:104145884chr14:104136518ENST00000557450+115464_4970585.0RepeatNote=TPR 6
TgeneKLC1chr14:104145884chr14:104136518ENST0000024648951627_156295638.0Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000033455351727_156295668.6666666666666Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000034783951627_156295629.0Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000034852051527_156295585.0Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000038974451527_156295898.3333333333334Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000045292951627_156295619.0Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000055328651427_156295561.0Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST0000055745051527_156295585.0Coiled coil.
TgeneKLC1chr14:104145884chr14:104136518ENST00000246489516213_246295638.0RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000246489516255_288295638.0RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000334553517213_246295668.6666666666666RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000334553517255_288295668.6666666666666RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000347839516213_246295629.0RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000347839516255_288295629.0RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000348520515213_246295585.0RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000348520515255_288295585.0RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000389744515213_246295898.3333333333334RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000389744515255_288295898.3333333333334RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000452929516213_246295619.0RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000452929516255_288295619.0RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000553286514213_246295561.0RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000553286514255_288295561.0RepeatNote=TPR 2
TgeneKLC1chr14:104145884chr14:104136518ENST00000557450515213_246295585.0RepeatNote=TPR 1
TgeneKLC1chr14:104145884chr14:104136518ENST00000557450515255_288295585.0RepeatNote=TPR 2


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Fusion Gene Sequence for KLC1-KLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KLC1-KLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLC1-KLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLC1-KLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource