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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLF6-ARMC4 (FusionGDB2 ID:42880)

Fusion Gene Summary for KLF6-ARMC4

check button Fusion gene summary
Fusion gene informationFusion gene name: KLF6-ARMC4
Fusion gene ID: 42880
HgeneTgene
Gene symbol

KLF6

ARMC4

Gene ID

1316

55130

Gene nameKruppel like factor 6armadillo repeat containing 4
SynonymsBCD1|CBA1|COPEB|CPBP|GBF|PAC1|ST12|ZF9CILD23|gudu
Cytomap

10p15.2

10p12.1

Type of geneprotein-codingprotein-coding
DescriptionKrueppel-like factor 6B-cell-derived protein 1GC-rich binding factorGC-rich sites-binding factor GBFKruppel-like zinc finger protein Zf9core promoter element-binding proteinproto-oncogene BCD1protooncogene B-cell derived 1suppression of tumorigeniarmadillo repeat-containing protein 4testis tissue sperm-binding protein Li 74n
Modification date2020031320200313
UniProtAcc

Q99612

.
Ensembl transtripts involved in fusion geneENST00000497571, ENST00000173785, 
ENST00000469435, ENST00000542957, 
ENST00000239715, ENST00000480504, 
ENST00000305242, ENST00000537576, 
ENST00000545014, 
Fusion gene scores* DoF score7 X 8 X 3=1687 X 5 X 5=175
# samples 88
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLF6 [Title/Abstract] AND ARMC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLF6(3822298)-ARMC4(28196706), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLF6

GO:0045944

positive regulation of transcription by RNA polymerase II

18755691


check buttonFusion gene breakpoints across KLF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARMC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4962-01AKLF6chr10

3822298

-ARMC4chr10

28196706

-


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Fusion Gene ORF analysis for KLF6-ARMC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000497571ENST00000239715KLF6chr10

3822298

-ARMC4chr10

28196706

-
5CDS-intronENST00000497571ENST00000480504KLF6chr10

3822298

-ARMC4chr10

28196706

-
5UTR-3CDSENST00000173785ENST00000305242KLF6chr10

3822298

-ARMC4chr10

28196706

-
5UTR-3CDSENST00000173785ENST00000537576KLF6chr10

3822298

-ARMC4chr10

28196706

-
5UTR-3CDSENST00000173785ENST00000545014KLF6chr10

3822298

-ARMC4chr10

28196706

-
5UTR-intronENST00000173785ENST00000239715KLF6chr10

3822298

-ARMC4chr10

28196706

-
5UTR-intronENST00000173785ENST00000480504KLF6chr10

3822298

-ARMC4chr10

28196706

-
In-frameENST00000497571ENST00000305242KLF6chr10

3822298

-ARMC4chr10

28196706

-
In-frameENST00000497571ENST00000537576KLF6chr10

3822298

-ARMC4chr10

28196706

-
In-frameENST00000497571ENST00000545014KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-3CDSENST00000469435ENST00000305242KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-3CDSENST00000469435ENST00000537576KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-3CDSENST00000469435ENST00000545014KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-3CDSENST00000542957ENST00000305242KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-3CDSENST00000542957ENST00000537576KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-3CDSENST00000542957ENST00000545014KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-intronENST00000469435ENST00000239715KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-intronENST00000469435ENST00000480504KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-intronENST00000542957ENST00000239715KLF6chr10

3822298

-ARMC4chr10

28196706

-
intron-intronENST00000542957ENST00000480504KLF6chr10

3822298

-ARMC4chr10

28196706

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000497571KLF6chr103822298-ENST00000537576ARMC4chr1028196706-187910611741607477
ENST00000497571KLF6chr103822298-ENST00000305242ARMC4chr1028196706-204510611741700508
ENST00000497571KLF6chr103822298-ENST00000545014ARMC4chr1028196706-216510611741829551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000497571ENST00000537576KLF6chr103822298-ARMC4chr1028196706-0.0176219160.98237807
ENST00000497571ENST00000305242KLF6chr103822298-ARMC4chr1028196706-0.0105548560.98944515
ENST00000497571ENST00000545014KLF6chr103822298-ARMC4chr1028196706-0.029381340.9706187

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Fusion Genomic Features for KLF6-ARMC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLF6-ARMC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:3822298/chr10:28196706)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLF6

Q99612

.
FUNCTION: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLF6chr10:3822298chr10:28196706ENST00000497571-3462_70266284.0Motif9aaTAD%3B inactive
HgeneKLF6chr10:3822298chr10:28196706ENST00000497571-34200_224266284.0Zinc fingerC2H2-type 1
HgeneKLF6chr10:3822298chr10:28196706ENST00000497571-34230_254266284.0Zinc fingerC2H2-type 2
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520871_9108311045.0RepeatARM 7
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520912_9518311045.0RepeatARM 8
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520953_9928311045.0RepeatARM 9
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520994_10338311045.0RepeatARM 10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLF6chr10:3822298chr10:28196706ENST00000469435-1262_700282.0Motif9aaTAD%3B inactive
HgeneKLF6chr10:3822298chr10:28196706ENST00000542957-1362_700238.0Motif9aaTAD%3B inactive
HgeneKLF6chr10:3822298chr10:28196706ENST00000469435-12200_2240282.0Zinc fingerC2H2-type 1
HgeneKLF6chr10:3822298chr10:28196706ENST00000469435-12230_2540282.0Zinc fingerC2H2-type 2
HgeneKLF6chr10:3822298chr10:28196706ENST00000469435-12260_2820282.0Zinc fingerC2H2-type 3
HgeneKLF6chr10:3822298chr10:28196706ENST00000497571-34260_282266284.0Zinc fingerC2H2-type 3
HgeneKLF6chr10:3822298chr10:28196706ENST00000542957-13200_2240238.0Zinc fingerC2H2-type 1
HgeneKLF6chr10:3822298chr10:28196706ENST00000542957-13230_2540238.0Zinc fingerC2H2-type 2
HgeneKLF6chr10:3822298chr10:28196706ENST00000542957-13260_2820238.0Zinc fingerC2H2-type 3
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520484_5238311045.0RepeatARM 1
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520525_5648311045.0RepeatARM 2
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520622_6618311045.0RepeatARM 3
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520663_7028311045.0RepeatARM 4
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520746_7858311045.0RepeatARM 5
TgeneARMC4chr10:3822298chr10:28196706ENST000003052421520828_8678311045.0RepeatARM 6


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Fusion Gene Sequence for KLF6-ARMC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42880_42880_1_KLF6-ARMC4_KLF6_chr10_3822298_ENST00000497571_ARMC4_chr10_28196706_ENST00000305242_length(transcript)=2045nt_BP=1061nt
GGCGGGGGCGGAGGGGGAGGCTGGCAGCGGAGCTTTGAATAGGGAAGTTTTGCAGGGGTTACGTTTGCAGTCAGTCCGGTGTTTGCAAAT
ATTGTGTGGGCTCCGCGCGCTGCGGGCTGCGGGAGGGTCCGGCCGGGCGTCTCTGCGAGCCTGGAGTTTGCATGAAACTTTCACCTGCGC
TCCGGGGAGACTTTCGGCTCCGGCTCCCACCGCGCGCCTCGCCGCCCTCGCGACCGCGGGCTCCGTCCAACCCGGCCCGACATGGACGTG
CTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAGTACTGGCAA
CAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTG
TGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCG
AGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCC
AAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAA
CTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCA
GGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAA
AGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGA
AGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGATCGCTTAGAT
GGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGCATCAAAAAT
GCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAAGAAGTTCTG
GCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCTTTATTGTCC
AAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAATAGAGTGGCC
TTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAGGCCTTGTAC
CAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGCTTCTACTGGATATGGTTGGGTCCCCTGACCAG
GATCTCCAGGAAGCTGCAGCTGGTTGTATATCCAATATCCGCAGGCTGGCTCTTGCTACAGAGAAGGCAAGATACACTTGAAATTTAAAT
GGACATTACAAGCTATCAAATTCTACATGACACAGGACATGTCACTCCCATGGCCAGAAAGCCTAAATTGGGAAACAGTTGTTAGCAAAC
CCTTTCAACCATCTAAATGAAAACACACAAATTGAAAATGCACAGAATGTTTTTCATCTGAAAATTGCATGGAGACTTTTGTTTCTATTT
AATGTTTTCGAGATATGACATGTGATAAGATGGAAAGCCAATAAACCTGTGATAAGTTTCTAAGAATATGAGAATATACGTATATGATGT

>42880_42880_1_KLF6-ARMC4_KLF6_chr10_3822298_ENST00000497571_ARMC4_chr10_28196706_ENST00000305242_length(amino acids)=508AA_BP=245
MRSGETFGSGSHRAPRRPRDRGLRPTRPDMDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQE
DLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSS
PELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRF
ARSDELTRHFRKHTGAKPFKCSHCDRIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKE
VLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQA

--------------------------------------------------------------
>42880_42880_2_KLF6-ARMC4_KLF6_chr10_3822298_ENST00000497571_ARMC4_chr10_28196706_ENST00000537576_length(transcript)=1879nt_BP=1061nt
GGCGGGGGCGGAGGGGGAGGCTGGCAGCGGAGCTTTGAATAGGGAAGTTTTGCAGGGGTTACGTTTGCAGTCAGTCCGGTGTTTGCAAAT
ATTGTGTGGGCTCCGCGCGCTGCGGGCTGCGGGAGGGTCCGGCCGGGCGTCTCTGCGAGCCTGGAGTTTGCATGAAACTTTCACCTGCGC
TCCGGGGAGACTTTCGGCTCCGGCTCCCACCGCGCGCCTCGCCGCCCTCGCGACCGCGGGCTCCGTCCAACCCGGCCCGACATGGACGTG
CTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAGTACTGGCAA
CAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTG
TGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCG
AGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCC
AAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAA
CTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCA
GGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAA
AGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGA
AGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGATCGCTTAGAT
GGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGCATCAAAAAT
GCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAAGAAGTTCTG
GCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCTTTATTGTCC
AAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAATAGAGTGGCC
TTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAGGCCTTGTAC
CAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGAAAAACATTTTTATCTCTTAGAAGAAATGACTA
GAGTGAACCTCAAAACCTCATCTGCAAATTGACTCATGGATCCATAAATTCACTCCTGGACCCCAGTTGAGAACCCTGACCCTAAGGATT
CTGAGCCTGCAAACCCTGGAGAAAAGTGGGGTTTGGCTGATCTCAGCTGGGCCAGGTGAGGATTAGCACCAGGTTGCAAGTAGATTCAAT

>42880_42880_2_KLF6-ARMC4_KLF6_chr10_3822298_ENST00000497571_ARMC4_chr10_28196706_ENST00000537576_length(amino acids)=477AA_BP=245
MRSGETFGSGSHRAPRRPRDRGLRPTRPDMDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQE
DLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSS
PELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRF
ARSDELTRHFRKHTGAKPFKCSHCDRIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKE
VLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQA

--------------------------------------------------------------
>42880_42880_3_KLF6-ARMC4_KLF6_chr10_3822298_ENST00000497571_ARMC4_chr10_28196706_ENST00000545014_length(transcript)=2165nt_BP=1061nt
GGCGGGGGCGGAGGGGGAGGCTGGCAGCGGAGCTTTGAATAGGGAAGTTTTGCAGGGGTTACGTTTGCAGTCAGTCCGGTGTTTGCAAAT
ATTGTGTGGGCTCCGCGCGCTGCGGGCTGCGGGAGGGTCCGGCCGGGCGTCTCTGCGAGCCTGGAGTTTGCATGAAACTTTCACCTGCGC
TCCGGGGAGACTTTCGGCTCCGGCTCCCACCGCGCGCCTCGCCGCCCTCGCGACCGCGGGCTCCGTCCAACCCGGCCCGACATGGACGTG
CTCCCCATGTGCAGCATCTTCCAGGAGCTCCAGATCGTGCACGAGACCGGCTACTTCTCGGCGCTGCCGTCTCTGGAGGAGTACTGGCAA
CAGACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTG
TGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCG
AGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCC
AAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAA
CTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCA
GGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAA
AGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGA
AGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGATAATTGATCGCTTAGAT
GGAGTTCGTTTGTTGTGGTCCCTGCTGAAAAATCCTCACCCAGACGTGAAGGCCAGCGCAGCATGGGCACTCTGTCCATGCATCAAAAAT
GCAAAGGATGCTGGGGAAATGGTTCGTTCCTTTGTTGGTGGTTTGGAACTTATTGTCAATTTACTGAAATCAGATAACAAAGAAGTTCTG
GCAAGTGTATGTGCTGCCATTACCAACATAGCAAAAGATCAAGAAAATTTAGCTGTTATCACAGATCATGGAGTTGTTCCTTTATTGTCC
AAACTGGCAAATACAAATAACAATAAATTGAGACATCATCTAGCAGAAGCTATTTCACGTTGCTGTATGTGGGGCAGGAATAGAGTGGCC
TTCGGTGAGCACAAAGCAGTGGCTCCACTAGTGCGTTATCTGAAATCAAATGACACCAACGTGCATCGGGCGACAGCTCAGGCCTTGTAC
CAACTCTCAGAAGACGCCGATAACTGCATCACCATGCATGAGAATGGTGCAGTAAAGACAGAGTCTCGCCATGTCGCCAGGCTAGAGTGC
AGTGACAACGATCTTGGCTCACTGCAACCTCCACCTCCCGGATTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGC
TTCTACTGGATATGGTTGGGTCCCCTGACCAGGATCTCCAGGAAGCTGCAGCTGGTTGTATATCCAATATCCGCAGGCTGGCTCTTGCTA
CAGAGAAGGCAAGATACACTTGAAATTTAAATGGACATTACAAGCTATCAAATTCTACATGACACAGGACATGTCACTCCCATGGCCAGA
AAGCCTAAATTGGGAAACAGTTGTTAGCAAACCCTTTCAACCATCTAAATGAAAACACACAAATTGAAAATGCACAGAATGTTTTTCATC
TGAAAATTGCATGGAGACTTTTGTTTCTATTTAATGTTTTCGAGATATGACATGTGATAAGATGGAAAGCCAATAAACCTGTGATAAGTT
TCTAAGAATATGAGAATATACGTATATGATGTATTTTTAGTTCAGTGATGCTTTTGTATTTGTGGCGATTTTAATAAAAAGGATATGGCC

>42880_42880_3_KLF6-ARMC4_KLF6_chr10_3822298_ENST00000497571_ARMC4_chr10_28196706_ENST00000545014_length(amino acids)=551AA_BP=245
MRSGETFGSGSHRAPRRPRDRGLRPTRPDMDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQE
DLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSS
PELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRF
ARSDELTRHFRKHTGAKPFKCSHCDRIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKE
VLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQA
LYQLSEDADNCITMHENGAVKTESRHVARLECSDNDLGSLQPPPPGFKRFSCLSLLSSWDYSFYWIWLGPLTRISRKLQLVVYPISAGWL

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Fusion Gene PPI Analysis for KLF6-ARMC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLF6-ARMC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLF6-ARMC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource