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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLF6-CREM (FusionGDB2 ID:42881)

Fusion Gene Summary for KLF6-CREM

Fusion gene summary

Fusion gene information	Fusion gene name: KLF6-CREM
	Fusion gene ID: 42881
		Hgene	Tgene
	Gene symbol	KLF6	CREM
	Gene ID	1316	1390
	Gene name	Kruppel like factor 6	cAMP responsive element modulator
	Synonyms	BCD1\|CBA1\|COPEB\|CPBP\|GBF\|PAC1\|ST12\|ZF9	CREM-2\|ICER\|hCREM-2
	Cytomap	10p15.2	10p11.21
	Type of gene	protein-coding	protein-coding
	Description	Krueppel-like factor 6B-cell-derived protein 1GC-rich binding factorGC-rich sites-binding factor GBFKruppel-like zinc finger protein Zf9core promoter element-binding proteinproto-oncogene BCD1protooncogene B-cell derived 1suppression of tumorigeni	cAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICER
	Modification date	20200313	20200313
	UniProtAcc	Q99612	Q03060
	Ensembl transtripts involved in fusion gene	ENST00000469435, ENST00000497571, ENST00000542957, ENST00000173785,	ENST00000333809, ENST00000337656, ENST00000345491, ENST00000348787, ENST00000374721, ENST00000374726, ENST00000374728, ENST00000374734, ENST00000395895, ENST00000429130, ENST00000439705, ENST00000469949, ENST00000479070, ENST00000489321, ENST00000342105, ENST00000344351, ENST00000354759, ENST00000356917, ENST00000361599, ENST00000395887, ENST00000460270, ENST00000463314, ENST00000463960, ENST00000468236, ENST00000473940, ENST00000474362, ENST00000474931, ENST00000484283, ENST00000487763, ENST00000488328, ENST00000488741, ENST00000489388, ENST00000490511,
Fusion gene scores	* DoF score	7 X 8 X 3=168	12 X 12 X 7=1008
	# samples	8	12
	** MAII score	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/1008*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KLF6 [Title/Abstract] AND CREM [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLF6(3827105)-CREM(35437296), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KLF6	GO:0045944	positive regulation of transcription by RNA polymerase II	18755691
Tgene	CREM	GO:0006355	regulation of transcription, DNA-templated	8206879

Fusion gene breakpoints across KLF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CREM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2020-01A	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
ChimerDB4	OV	TCGA-24-2020	KLF6	chr10	3827104	-	CREM	chr10	35437295	+

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Fusion Gene ORF analysis for KLF6-CREM

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000469435	ENST00000333809	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000333809	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000337656	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000337656	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000345491	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000345491	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000348787	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000348787	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000374721	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000374721	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000374726	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000374726	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000374728	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000374728	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000374734	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000374734	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000395895	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000395895	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000429130	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000429130	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000439705	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000439705	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000469949	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000469949	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000479070	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000479070	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000469435	ENST00000489321	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000469435	ENST00000489321	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000333809	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000333809	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000337656	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000337656	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000345491	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000345491	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000348787	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000348787	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000374721	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000374721	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000374726	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000374726	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000374728	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000374728	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000374734	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000374734	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000395895	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000395895	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000429130	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000429130	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000439705	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000439705	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000469949	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000469949	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000479070	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000479070	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000497571	ENST00000489321	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000497571	ENST00000489321	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000333809	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000333809	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000337656	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000337656	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000345491	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000345491	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000348787	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000348787	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000374721	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000374721	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000374726	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000374726	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000374728	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000374728	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000374734	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000374734	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000395895	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000395895	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000429130	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000429130	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000439705	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000439705	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000469949	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000469949	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000479070	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000479070	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-5UTR	ENST00000542957	ENST00000489321	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-5UTR	ENST00000542957	ENST00000489321	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000342105	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000342105	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000344351	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000344351	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000354759	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000354759	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000356917	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000356917	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000361599	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000361599	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000395887	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000395887	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000460270	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000460270	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000463314	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000463314	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000463960	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000463960	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000468236	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000468236	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000473940	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000473940	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000474362	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000474362	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000474931	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000474931	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000484283	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000484283	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000487763	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000487763	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000488328	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000488328	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000488741	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000488741	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000489388	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000489388	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000469435	ENST00000490511	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000469435	ENST00000490511	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000342105	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000342105	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000344351	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000344351	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000354759	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000354759	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000356917	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000356917	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000361599	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000361599	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000395887	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000395887	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000460270	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000460270	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000463314	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000463314	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000463960	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000463960	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000468236	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000468236	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000473940	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000473940	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000474362	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000474362	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000474931	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000474931	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000484283	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000484283	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000487763	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000487763	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000488328	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000488328	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000488741	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000488741	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000489388	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000489388	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000497571	ENST00000490511	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000497571	ENST00000490511	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000342105	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000342105	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000344351	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000344351	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000354759	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000354759	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000356917	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000356917	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000361599	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000361599	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000395887	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000395887	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000460270	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000460270	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000463314	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000463314	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000463960	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000463960	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000468236	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000468236	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000473940	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000473940	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000474362	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000474362	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000474931	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000474931	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000484283	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000484283	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000487763	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000487763	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000488328	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000488328	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000488741	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000488741	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000489388	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000489388	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
5CDS-intron	ENST00000542957	ENST00000490511	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
5CDS-intron	ENST00000542957	ENST00000490511	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000333809	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000333809	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000337656	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000337656	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000345491	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000345491	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000348787	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000348787	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000374721	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000374721	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000374726	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000374726	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000374728	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000374728	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000374734	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000374734	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000395895	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000395895	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000429130	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000429130	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000439705	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000439705	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000469949	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000469949	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000479070	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000479070	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-5UTR	ENST00000173785	ENST00000489321	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-5UTR	ENST00000173785	ENST00000489321	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000342105	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000342105	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000344351	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000344351	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000354759	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000354759	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000356917	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000356917	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000361599	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000361599	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000395887	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000395887	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000460270	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000460270	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000463314	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000463314	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000463960	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000463960	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000468236	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000468236	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000473940	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000473940	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000474362	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000474362	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000474931	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000474931	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000484283	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000484283	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000487763	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000487763	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000488328	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000488328	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000488741	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000488741	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000489388	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000489388	KLF6	chr10	3827104	-	CREM	chr10	35437295	+
intron-intron	ENST00000173785	ENST00000490511	KLF6	chr10	3827105	-	CREM	chr10	35437296	+
intron-intron	ENST00000173785	ENST00000490511	KLF6	chr10	3827104	-	CREM	chr10	35437295	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for KLF6-CREM

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KLF6	chr10	3827104	-	CREM	chr10	35437299	+	8.28E-06	0.9999918
KLF6	chr10	3827104	-	CREM	chr10	35437299	+	8.28E-06	0.9999918
KLF6	chr10	3827104	-	CREM	chr10	35437299	+	8.28E-06	0.9999918
KLF6	chr10	3827104	-	CREM	chr10	35437299	+	8.28E-06	0.9999918

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KLF6-CREM

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3827105/:35437296)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLF6 Q99612	CREM Q03060
FUNCTION: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}.	FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269\|PubMed:10373550}.; FUNCTION: [Isoform 6]: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for KLF6-CREM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for KLF6-CREM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KLF6-CREM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KLF6-CREM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source