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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KLHDC4-ZCCHC14 (FusionGDB2 ID:42929) |
Fusion Gene Summary for KLHDC4-ZCCHC14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KLHDC4-ZCCHC14 | Fusion gene ID: 42929 | Hgene | Tgene | Gene symbol | KLHDC4 | ZCCHC14 | Gene ID | 54758 | 23174 |
| Gene name | kelch domain containing 4 | zinc finger CCHC-type containing 14 | |
| Synonyms | - | BDG-29|BDG29 | |
| Cytomap | 16q24.2 | 16q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kelch domain-containing protein 4 | zinc finger CCHC domain-containing protein 14zinc finger, CCHC domain containing 14 | |
| Modification date | 20200320 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000270583, ENST00000347925, ENST00000353170, ENST00000566349, | ENST00000268616, | |
| Fusion gene scores | * DoF score | 8 X 6 X 5=240 | 3 X 3 X 2=18 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KLHDC4 [Title/Abstract] AND ZCCHC14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ZCCHC14(87493613)-KLHDC4(87760530), # samples:1 KLHDC4(87788800)-ZCCHC14(87493737), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ZCCHC14-KLHDC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across KLHDC4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ZCCHC14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-E7-A7DV-01A | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - |
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Fusion Gene ORF analysis for KLHDC4-ZCCHC14 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000270583 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - |
| In-frame | ENST00000347925 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - |
| In-frame | ENST00000353170 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - |
| intron-3CDS | ENST00000566349 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000353170 | KLHDC4 | chr16 | 87788800 | - | ENST00000268616 | ZCCHC14 | chr16 | 87493737 | - | 6932 | 207 | 9 | 2897 | 962 |
| ENST00000347925 | KLHDC4 | chr16 | 87788800 | - | ENST00000268616 | ZCCHC14 | chr16 | 87493737 | - | 7180 | 455 | 17 | 3145 | 1042 |
| ENST00000270583 | KLHDC4 | chr16 | 87788800 | - | ENST00000268616 | ZCCHC14 | chr16 | 87493737 | - | 7153 | 428 | 26 | 3118 | 1030 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000353170 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - | 0.000321025 | 0.99967897 |
| ENST00000347925 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - | 0.000295871 | 0.99970406 |
| ENST00000270583 | ENST00000268616 | KLHDC4 | chr16 | 87788800 | - | ZCCHC14 | chr16 | 87493737 | - | 0.000282819 | 0.9997172 |
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Fusion Genomic Features for KLHDC4-ZCCHC14 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KLHDC4-ZCCHC14 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:87493613/chr16:87760530) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 420_425 | 53 | 950.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 704_747 | 53 | 950.0 | Compositional bias | Note=Ser-rich | |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 748_751 | 53 | 950.0 | Compositional bias | Note=Poly-Gly | |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 763_769 | 53 | 950.0 | Compositional bias | Note=His-rich | |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 772_783 | 53 | 950.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 906_923 | 53 | 950.0 | Zinc finger | CCHC-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000270583 | - | 4 | 12 | 133_187 | 123 | 564.3333333333334 | Repeat | Note=Kelch 2 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000270583 | - | 4 | 12 | 188_241 | 123 | 564.3333333333334 | Repeat | Note=Kelch 3 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000270583 | - | 4 | 12 | 243_289 | 123 | 564.3333333333334 | Repeat | Note=Kelch 4 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000270583 | - | 4 | 12 | 308_361 | 123 | 564.3333333333334 | Repeat | Note=Kelch 5 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000270583 | - | 4 | 12 | 443_494 | 123 | 564.3333333333334 | Repeat | Note=Kelch 6 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000270583 | - | 4 | 12 | 77_129 | 123 | 564.3333333333334 | Repeat | Note=Kelch 1 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000347925 | - | 4 | 11 | 133_187 | 123 | 524.6666666666666 | Repeat | Note=Kelch 2 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000347925 | - | 4 | 11 | 188_241 | 123 | 524.6666666666666 | Repeat | Note=Kelch 3 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000347925 | - | 4 | 11 | 243_289 | 123 | 524.6666666666666 | Repeat | Note=Kelch 4 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000347925 | - | 4 | 11 | 308_361 | 123 | 524.6666666666666 | Repeat | Note=Kelch 5 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000347925 | - | 4 | 11 | 443_494 | 123 | 524.6666666666666 | Repeat | Note=Kelch 6 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000347925 | - | 4 | 11 | 77_129 | 123 | 524.6666666666666 | Repeat | Note=Kelch 1 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000353170 | - | 2 | 10 | 133_187 | 66 | 521.0 | Repeat | Note=Kelch 2 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000353170 | - | 2 | 10 | 188_241 | 66 | 521.0 | Repeat | Note=Kelch 3 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000353170 | - | 2 | 10 | 243_289 | 66 | 521.0 | Repeat | Note=Kelch 4 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000353170 | - | 2 | 10 | 308_361 | 66 | 521.0 | Repeat | Note=Kelch 5 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000353170 | - | 2 | 10 | 443_494 | 66 | 521.0 | Repeat | Note=Kelch 6 |
| Hgene | KLHDC4 | chr16:87788800 | chr16:87493737 | ENST00000353170 | - | 2 | 10 | 77_129 | 66 | 521.0 | Repeat | Note=Kelch 1 |
| Tgene | ZCCHC14 | chr16:87788800 | chr16:87493737 | ENST00000268616 | 0 | 13 | 29_37 | 53 | 950.0 | Compositional bias | Note=Poly-Gly |
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Fusion Gene Sequence for KLHDC4-ZCCHC14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >42929_42929_1_KLHDC4-ZCCHC14_KLHDC4_chr16_87788800_ENST00000270583_ZCCHC14_chr16_87493737_ENST00000268616_length(transcript)=7153nt_BP=428nt GCGGAGAGCGCGGGCCGTTTTCTTTCCTGGTGTCCCGTCGCGGCTTGGGACCCGGCAAGATGGGCAAGAAGGGCAAGAAGGAGAAGAAGG GCCGCGGCGCGGAGAAGACGGCCGCCAAGATGGAGAAGAAGGTGTCTAAGCGCTCGCGGAAGGAGGAGGAAGACCTGGAAGCGCTCATAG CCCATTTCCAGACACTCGATGCCAAGAGGACTCAGACTGTGGAACTTCCGTGCCCCCCACCCTCACCAAGGTTAAATGCCTCCCTCTCGG TTCATCCTGAGAAAGATGAGTTAATCCTTTTTGGAGGTGAATATTTCAACGGCCAAAAAACTTTTTTGTATAACGAGCTCTATGTCTACA ATACCAGAAAGGACACCTGGACCAAAGTTGACATCCCCAGTCCACCTCCGAGGCGCTGTGCTCACCAGATCACTCCAAGAACTGAGGCCC CTGTCAGCAGTGTCAGTAATAGTTTGGAGAATGCCCTGCACACATCAGCACATTCCACGGAGGAGTCGCTGCCCAAGAGGCCCTTAGGAA AACACAGCAAAGTGAGTGTTGAAAAGATAGACCTGAAGGGATTATCACACACAAAAAATGACAGAAATGTTGAATGTTCCTTTGAGGTCT TGTGGTCTGATTCTTCAATAACATCAGTAACCAAATCTTCCTCTGAAGTGACGGAATTTATTTCAAAGCTATGTCAGCTCTATCCTGAAG AGAACTTGGAGAAACTCATTCCTTGCTTAGCTGGTCCGGACGCATTTTATGTGGAGCGAAACCACGTGGATCTGGACTCAGGCCTGAGGT ACCTGGCCTCATTACCTTCTCACGTGTTGAAAAATGACCATGTCAGGAGGTTTCTCAGCACTTCCTCTCCCCCACAGCAGCTTCAGAGTC CAAGTCCTGGCAATCCCTCCCTTTCTAAAGTAGGTACCGTGATGGGCGTGTCTGGAAGGCCTGTGTGTGGAGTGGCTGGTATCCCGTCCT CGCAGAGCGGAGCCCAGCACCACGGGCAGCACCCGGCCGGCTCCGCCGCCCCCTTGCCTCACTGCTCCCATGCGGGCAGCGCGGGCTCAG CCCTGGCCTACCGGACCCAGATGGACACATCACCTGCCATCCTCATGCCTTCCAGTCTGCAGACCCCTCAGACCCAGGAGCAGAATGGGA TTCTAGACTGGCTTAGGAAACTGCGTTTGCACAAGTATTACCCCGTCTTTAAGCAGCTCTCCATGGAGAAGTTTTTGAGCCTTACTGAAG AAGATCTGAATAAATTTGAGTCTCTTACCATGGGGGCAAAGAAGAAGCTCAAGACCCAGCTGGAGCTGGAAAAGGAGAAGTCAGAGAGAC GGTGCCTGAACCCCTCGGCCCCGCCGCTGGTCACCAGCAGTGGTGTGGCTCGAGTGCCCCCCACCAGCCACGTCGGGCCCGTGCAGTCGG GGCGGGGCAGCCATGCAGCAGAGCTGCGGGTGGAAGTGGAGCAGCCCCATCACCAGCTGCCCCGGGAAGGCAGTTCCTCGGAGTACTCCA GCTCCTCCTCCAGCCCCATGGGGGTACAGGCCCGGGAAGAGAGCTCCGACAGCGCTGAGGAGAATGACAGACGTGTGGAGATTCACTTGG AGAGCTCTGACAAGGAGAAGCCGGTGATGCTGCTGAATCACTTCACTTCCAGTTCCGCCAGACCCACGGCCCAGGTTCTCCCTGTGCAGA ATGAGGCCAGCTCCAATCCATCAGGCCACCACCCCCTGCCCCCGCAGATGCTGAGCGCAGCCTCACACATCACACCCATCCGCATGCTGA ATTCCGTGCACAAGCCGGAAAGAGGGAGCGCGGACATGAAGCTCCTCTCGTCTTCTGTGCACTCACTTTTGTCTCTAGAAGAAAGGAATA AAGGATCTGGACCAAGAAGCAGCATGAAAGTGGACAAGAGCTTTGGCAGCGCCATGATGGACGTGCTGCCCGCGTCCGCACCCCACCAGC CTGTGCAGGTCCTCTCTGGGCTTTCGGAGAGCAGCTCCATGTCACCCACAGTCTCCTTTGGTCCCCGGACCAAAGTCGTGCATGCATCCA CGCTGGACAGGGTGCTGAAGACAGCACAGCAACCGGCCCTGGTCGTGGAGACCAGCACGGCCGCCACGGGGACGCCCAGCACAGTCCTCC ACGCCGCCCGTCCGCCCATCAAACTGCTGCTGTCGTCATCTGTTCCTGCTGATTCTGCCATTTCTGGGCAAACTTCCTGTCCTAATAATG TGCAAATAAGTGTGCCCCCTGCAATAATAAACCCCCGGACTGCTCTGTACACAGCCAACACCAAAGTTGCCTTTTCTGCAATGAGCAGTA TGCCAGTGGGCCCCCTGCAGGGTGGCTTCTGTGCAAACAGCAACACTGCCTCTCCCAGCAGCCACCCCTCCACGTCCTTTGCCAACATGG CCACGTTGCCCAGCTGCCCAGCCCCCAGCTCCAGCCCGGCGCTGTCCTCCGTCCCTGAAAGCAGTTTCTATAGCAGCAGTGGCGGTGGCG GCTCCACAGGAAACATTCCTGCCTCGAATCCGAACCACCACCACCACCACCACCATCAGCAGCCCCCGGCACCCCCGCAGCCCGCCCCAC CCCCGCCAGGCTGCATTGTGTGCACGTCCTGTGGCTGCAGCGGCAGCTGCGGCTCGAGTGGCCTGACTGTCAGCTACGCCAACTACTTCC AGCACCCGTTCTCCGGTCCGTCCGTGTTCACCTTCCCCTTCTTGCCCTTCAGTCCCATGTGCAGCAGCGGCTACGTCAGCGCCCAGCAGT ACGGCGGCGGCTCCACCTTCCCCGTCGTGCACGCCCCTTACAGCAGCAGCGGGACCCCAGACCCTGTCCTGAGTGGGCAGTCCACGTTTG CCGTGCCACCCATGCAGAACTTCATGGCAGGGACAGCAGGGGTGTACCAGACCCAAGGACTGGTGGGCAGTAGCAATGGTTCCAGTCACA AAAAGAGCGGGAACCTATCTTGTTACAACTGCGGGGCCACTGGTCACCGCGCCCAGGACTGCAAACAGCCGTCCATGGACTTCAACCGGC CAGGTACTTTTAGGTTGAAATACGCCCCTCCAGCAGAAAGTCTGGACTCCACAGATTGATATTTTTCTCTGGCAACAGAACGTTATTAAG CCATGGAGACATAAGGAAAATTAAATACAAAACTGAGAAGTCTAGTTGCTGTTGAGCTTAATCTTTTTAATCCAAAGGTGCTTTACTTTT CCTAGACTGGATAGAAAATCTAGCGTAGAAGTGCATCAAACTCGATTTATTGCCAAAACCCTAGATTGGAGCTTGGTGTCAGAACTCGCC TAGTGGGCATCTCTGTGGCTGGTGAGATCGGCCACCTCCACTTTTGGTTGCAGTGCAGAGACGCCATGTCTCCCGAAGAGCATTGCCATC ACTGGCCCTCCTAGGCTCACACGTCAATTCCAGGGCAGCTACACGTGGTCTGAATCGAGAACCGAGCTTGGAGTTCTCCAAGTGGAGTTC CACCCGCCGGACTCCTGACACCCCTGGGCTAGGGAAAATGTCGACTTTGTTTTGTTCTGTTCCTAAAGTGATTAGCACTAATCTCTGGGA TTTTTAAGGATTGCACTACAGAAGAATGTACCCTGATGTAAATCTCTGCGGTTCTGGGAGCCAAACTCCTCTGAGAACAGTCAGTGCAAG AGACTCCAATAATCCATATTGAAAGAGTCAGCACCAGCAGAGGCTACTCGACTTAGGACGCAACAGAGGTTTTAGTATTTCCTTCCCTCC TCCAAGCACTTGTAGCAGTTTCAGGTTTTTAATTTTTTTCTGCAAATAAATCTAAACTACGTTATTAAATAGAAATAGTTTACTCGCAAC AACTTAATTTCTAAGGGTCCAAGTCCCAGAGAATCCATAGTCGTCAAAGCTTTGAGAGTATCTTTCTTCCCAGCCAGTCAGTGGCTTTGA GCCCTATCTTCCACTACAAATGACCTCTCGAGGGGGGACGGCGACAGCGCGGCTCTGTGAGTGGCTGTGAGGATGCTGCACGTCCTCAGC AGAGTTTGCAAGTTGCTTTATCTCCCACGGGCTCCCCAAGAACCTCCAACCCCGAGGCTTATCGCTAGCGGATTCACACCTGAGACAGAC ATTTCAACAATGATACAGTCCTGTCATTTATCAGCAAAAGATTGGGAATTTTCTCCTGTCAACTTCTTTTGTATTAGGCTGTGTATTGAT AGTTAATTCCGTTAAAAATTACTTGGAAAACAGTGGGAAGTGGTAGGACTCTGGAAGAGGCCACACACCCGAGAGCTGCGAGATCTGTGC AAGTCTGGTTTTGGTTAGGTAGTAATAAAAGTCCTCACTGTAGATCTCTAAATTTCAACCCACGGAAATGAAAGCCTTTTGTCTGAAATT TACGGACTTAAATCTTCAAGGTTAAAGGGAATTTTCTGCTCAAATAATACTCTTATCGAAAATGCTAAAGTCTTCAATGTTAAAATACTG ATTGGTAAAATCTTGCAGTTGGGATTTTGCAGTTGGATATTTATTTTAAAAAAAATTATAATATTCAGACTATTCTTAAAATGGGACAAT CAGCCTCATGAAAAATTGATGTAAATCAGAAGAATACCCTAGAATGAGGCCTTGTGATGTGAGCGTTCAATTTGAAGAGCAGTTCCTAAC TTCATAGAAACTAAAGCAGAAAGTTGTTACATTTTTTTTATGACAGGCTTTTAGTAGAATTTTTTAGTTTTATTTTAGTTGAATTTTATT TCTATGCAATGCAGAATTAACAGACCTCTTCTCCTCATGGTACACAGTATTACAGTGTTGAAGTAATGGTGATGCTTATTACAACAGCTA TTTAGGGGAATGTTACGTTGATCTCTTAAATTGTAAACACTACAAAATGTCAAAATAATGAGAACTGACACAACTTTGCCTTAAAGAGTA CTAGACTGGACCTTCTCATATTACGTTTAAGGAAGACTTAGAGTGTTCATTGATGTTTACGATTTTAATATTTCTGAAGGCCATTACAGT GGCCTGGATATGTGCTGAAAGCCAAACTTTTAAATTTTTTGGTTTTTTTAAGCAAAGAAATATTTTAAATAAATCCTATTTCAACACTGA AATTGTTGAAAACCGTCTCATAACAAAAGGAAAAAACATTGGAATTTTTGTTTTAGTGGTCAGTATAGGGGAATGAAAGCGTCTGTTGTT ACCCACGTAACTATTTTGATAAGTATTAGAGGTTAACCTTAAATCCAGCAAAACATTAAAACAGAAACTTTTCAACTTGGAGCCTGCCAT TCAGCGTTGAGGTAGATGAGTTCCGACACTGTCACGGCTGTGTTCCCAGCAGCGAAGGCCTCTGCGGAGCTGCCAGTCGTCTTGAACGTG CATGGGCGGCGTGTGACATCTCCAGGGAGGCCGTCCGAAGTCGAGAATCGTCAGCTGTAAGTAGGAGCTACACAGCGCAGAGAAAATGGA ACCACCCATCCGTGAGGCCTCTTTCCGGAGGGAGCCGCACACTTGGACTTGAGAGTTTGCCAGCAGCGAGCTCGGATGCATCTCTCCAAA AGCCACCAAGGTCGGCGCGTCTGAAGAGCGTTTTGCGGTCATCAGACTTCCTCATCTGAAAACACAGAACATACTGACCCTTTCAAGTAC TTAGTCATTTTCCTGAAAGTGTGGTCTGTTTCAGAATGCTGTGGCAACCAGGTAGGTGTGGCACTGGCCATGTGCCACGTCTTTGCCCTT TGTAGTCTGTCAGATATTAAAGTTTCTAACCCTGTTTTTTTAATCTCCAAGAATGGGGAAAGTGGAATGTAGAGATGGAAGCAGAACGTG ATGTTTGGATACAACAGCTATTTAATCCTTTTTTATTTTTTAAGCAAAACACTCAGTTTTCTACCTTATTTTCTAATGTTGATTTCATGG TAATACTGACAGTTGGAAGTGTTTAACATAAAAACTCATTGCTAAAGAGCACTGAGGAAATGGGAGCTAGCGCACTTGTAATAAAAATAA AGACAAAATATTTTCTTGAATGCATATATGTGATTGGGTATTTTAAAAACCAGTATCATCTGTCATCTCCAAAAGATTACAGGAGTCAGC TTGTTAATACAGTAGTGTTAGTAGGTTCTGTATTTTTAATTCAGTACTTAGAATTCTAGGTCCTTTATTGCCCAAAGTCAGCACAGTTAG TTTATACCACAGACTCTGTCTTGGGGCACAGTAGTGGGGCGGGGTAGTGACTTTGCCTAAACATCACCCAGCTGGAACAGAGGCTGAGCG GGGCTTTAGGCACTTGCCAGATGGGAACTGGGTTGCACCCTCCTTGCTCCCTGTCATTTTCTTGTCACTCTTCCTGCTTCCCAGTGTTTT ATTTTATGCCTTGCTCGTTGTACATCATGATGACTGATGGTCTTCAAGGTTGTGAGGAAAGCCGTCTCCCTGCTTGACTCGACTGCTGTC CCAGAGGAGAGTCCTGTGCGACCTGAGCGGGGGTGGCTGCCATTTCCAGCATGCAGGTGACTTCCAAAGAATGAGTCAGGTGGCACTGAA AGCCATGGGTTCTGAAGAGGCGAATTTGTTGAAAAGTCCCAAGGGTCTGAATGAAAGCATCTTTAATCAACACTCAACACTCGCAATATT CTAGAAAACCATATACTGTGCTGGTTGAGGCCAAAGGTTAACATTGCTCCACTGTTCACCAAGGAAGGGGGCAGTGGCCATCCGCCGCGG CCTCACGTGCGTTGTAACAAGCCCTCATCACATGTGTGAGTCTTACGTGCACAAAAAGAGAAGGCTTTGGTACTGAAACTGGACACCTTG TGTACTCGATACCTTCACAGCTTCTATTGGACATATTTTCTTTTTAGGAATGAAGGAAAATTCTCCCATTTTTGAGCCATTCTTTTGTCA ATTCTACAAAATTGCATGTAACTTTATAAATATTTTTAAAAGATATAGTTTTGTAAATATTTAATATTCCGCTAATTTGATTTTGAATTG TAAATGTCAAGTATTCTGTTTTTGGGGTTTTTATGTTTTATTATACTTTGTTAAAAAGGACAAATTGTACATTTTTAGAATGTTTTTATG >42929_42929_1_KLHDC4-ZCCHC14_KLHDC4_chr16_87788800_ENST00000270583_ZCCHC14_chr16_87493737_ENST00000268616_length(amino acids)=1030AA_BP=1 MVSRRGLGPGKMGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRLNASLSVHPEKDELI LFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQITPRTEAPVSSVSNSLENALHTSAHSTEESLPKRPLGKHSKVSVEK IDLKGLSHTKNDRNVECSFEVLWSDSSITSVTKSSSEVTEFISKLCQLYPEENLEKLIPCLAGPDAFYVERNHVDLDSGLRYLASLPSHV LKNDHVRRFLSTSSPPQQLQSPSPGNPSLSKVGTVMGVSGRPVCGVAGIPSSQSGAQHHGQHPAGSAAPLPHCSHAGSAGSALAYRTQMD TSPAILMPSSLQTPQTQEQNGILDWLRKLRLHKYYPVFKQLSMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSERRCLNPSAPP LVTSSGVARVPPTSHVGPVQSGRGSHAAELRVEVEQPHHQLPREGSSSEYSSSSSSPMGVQAREESSDSAEENDRRVEIHLESSDKEKPV MLLNHFTSSSARPTAQVLPVQNEASSNPSGHHPLPPQMLSAASHITPIRMLNSVHKPERGSADMKLLSSSVHSLLSLEERNKGSGPRSSM KVDKSFGSAMMDVLPASAPHQPVQVLSGLSESSSMSPTVSFGPRTKVVHASTLDRVLKTAQQPALVVETSTAATGTPSTVLHAARPPIKL LLSSSVPADSAISGQTSCPNNVQISVPPAIINPRTALYTANTKVAFSAMSSMPVGPLQGGFCANSNTASPSSHPSTSFANMATLPSCPAP SSSPALSSVPESSFYSSSGGGGSTGNIPASNPNHHHHHHHQQPPAPPQPAPPPPGCIVCTSCGCSGSCGSSGLTVSYANYFQHPFSGPSV FTFPFLPFSPMCSSGYVSAQQYGGGSTFPVVHAPYSSSGTPDPVLSGQSTFAVPPMQNFMAGTAGVYQTQGLVGSSNGSSHKKSGNLSCY -------------------------------------------------------------- >42929_42929_2_KLHDC4-ZCCHC14_KLHDC4_chr16_87788800_ENST00000347925_ZCCHC14_chr16_87493737_ENST00000268616_length(transcript)=7180nt_BP=455nt CTCCGCCCCACGAGCACCTGTTTCCGAGCGGAGAGCGCGGGCCGTTTTCTTTCCTGGTGTCCCGTCGCGGCTTGGGACCCGGCAAGATGG GCAAGAAGGGCAAGAAGGAGAAGAAGGGCCGCGGCGCGGAGAAGACGGCCGCCAAGATGGAGAAGAAGGTGTCTAAGCGCTCGCGGAAGG AGGAGGAAGACCTGGAAGCGCTCATAGCCCATTTCCAGACACTCGATGCCAAGAGGACTCAGACTGTGGAACTTCCGTGCCCCCCACCCT CACCAAGGTTAAATGCCTCCCTCTCGGTTCATCCTGAGAAAGATGAGTTAATCCTTTTTGGAGGTGAATATTTCAACGGCCAAAAAACTT TTTTGTATAACGAGCTCTATGTCTACAATACCAGAAAGGACACCTGGACCAAAGTTGACATCCCCAGTCCACCTCCGAGGCGCTGTGCTC ACCAGATCACTCCAAGAACTGAGGCCCCTGTCAGCAGTGTCAGTAATAGTTTGGAGAATGCCCTGCACACATCAGCACATTCCACGGAGG AGTCGCTGCCCAAGAGGCCCTTAGGAAAACACAGCAAAGTGAGTGTTGAAAAGATAGACCTGAAGGGATTATCACACACAAAAAATGACA GAAATGTTGAATGTTCCTTTGAGGTCTTGTGGTCTGATTCTTCAATAACATCAGTAACCAAATCTTCCTCTGAAGTGACGGAATTTATTT CAAAGCTATGTCAGCTCTATCCTGAAGAGAACTTGGAGAAACTCATTCCTTGCTTAGCTGGTCCGGACGCATTTTATGTGGAGCGAAACC ACGTGGATCTGGACTCAGGCCTGAGGTACCTGGCCTCATTACCTTCTCACGTGTTGAAAAATGACCATGTCAGGAGGTTTCTCAGCACTT CCTCTCCCCCACAGCAGCTTCAGAGTCCAAGTCCTGGCAATCCCTCCCTTTCTAAAGTAGGTACCGTGATGGGCGTGTCTGGAAGGCCTG TGTGTGGAGTGGCTGGTATCCCGTCCTCGCAGAGCGGAGCCCAGCACCACGGGCAGCACCCGGCCGGCTCCGCCGCCCCCTTGCCTCACT GCTCCCATGCGGGCAGCGCGGGCTCAGCCCTGGCCTACCGGACCCAGATGGACACATCACCTGCCATCCTCATGCCTTCCAGTCTGCAGA CCCCTCAGACCCAGGAGCAGAATGGGATTCTAGACTGGCTTAGGAAACTGCGTTTGCACAAGTATTACCCCGTCTTTAAGCAGCTCTCCA TGGAGAAGTTTTTGAGCCTTACTGAAGAAGATCTGAATAAATTTGAGTCTCTTACCATGGGGGCAAAGAAGAAGCTCAAGACCCAGCTGG AGCTGGAAAAGGAGAAGTCAGAGAGACGGTGCCTGAACCCCTCGGCCCCGCCGCTGGTCACCAGCAGTGGTGTGGCTCGAGTGCCCCCCA CCAGCCACGTCGGGCCCGTGCAGTCGGGGCGGGGCAGCCATGCAGCAGAGCTGCGGGTGGAAGTGGAGCAGCCCCATCACCAGCTGCCCC GGGAAGGCAGTTCCTCGGAGTACTCCAGCTCCTCCTCCAGCCCCATGGGGGTACAGGCCCGGGAAGAGAGCTCCGACAGCGCTGAGGAGA ATGACAGACGTGTGGAGATTCACTTGGAGAGCTCTGACAAGGAGAAGCCGGTGATGCTGCTGAATCACTTCACTTCCAGTTCCGCCAGAC CCACGGCCCAGGTTCTCCCTGTGCAGAATGAGGCCAGCTCCAATCCATCAGGCCACCACCCCCTGCCCCCGCAGATGCTGAGCGCAGCCT CACACATCACACCCATCCGCATGCTGAATTCCGTGCACAAGCCGGAAAGAGGGAGCGCGGACATGAAGCTCCTCTCGTCTTCTGTGCACT CACTTTTGTCTCTAGAAGAAAGGAATAAAGGATCTGGACCAAGAAGCAGCATGAAAGTGGACAAGAGCTTTGGCAGCGCCATGATGGACG TGCTGCCCGCGTCCGCACCCCACCAGCCTGTGCAGGTCCTCTCTGGGCTTTCGGAGAGCAGCTCCATGTCACCCACAGTCTCCTTTGGTC CCCGGACCAAAGTCGTGCATGCATCCACGCTGGACAGGGTGCTGAAGACAGCACAGCAACCGGCCCTGGTCGTGGAGACCAGCACGGCCG CCACGGGGACGCCCAGCACAGTCCTCCACGCCGCCCGTCCGCCCATCAAACTGCTGCTGTCGTCATCTGTTCCTGCTGATTCTGCCATTT CTGGGCAAACTTCCTGTCCTAATAATGTGCAAATAAGTGTGCCCCCTGCAATAATAAACCCCCGGACTGCTCTGTACACAGCCAACACCA AAGTTGCCTTTTCTGCAATGAGCAGTATGCCAGTGGGCCCCCTGCAGGGTGGCTTCTGTGCAAACAGCAACACTGCCTCTCCCAGCAGCC ACCCCTCCACGTCCTTTGCCAACATGGCCACGTTGCCCAGCTGCCCAGCCCCCAGCTCCAGCCCGGCGCTGTCCTCCGTCCCTGAAAGCA GTTTCTATAGCAGCAGTGGCGGTGGCGGCTCCACAGGAAACATTCCTGCCTCGAATCCGAACCACCACCACCACCACCACCATCAGCAGC CCCCGGCACCCCCGCAGCCCGCCCCACCCCCGCCAGGCTGCATTGTGTGCACGTCCTGTGGCTGCAGCGGCAGCTGCGGCTCGAGTGGCC TGACTGTCAGCTACGCCAACTACTTCCAGCACCCGTTCTCCGGTCCGTCCGTGTTCACCTTCCCCTTCTTGCCCTTCAGTCCCATGTGCA GCAGCGGCTACGTCAGCGCCCAGCAGTACGGCGGCGGCTCCACCTTCCCCGTCGTGCACGCCCCTTACAGCAGCAGCGGGACCCCAGACC CTGTCCTGAGTGGGCAGTCCACGTTTGCCGTGCCACCCATGCAGAACTTCATGGCAGGGACAGCAGGGGTGTACCAGACCCAAGGACTGG TGGGCAGTAGCAATGGTTCCAGTCACAAAAAGAGCGGGAACCTATCTTGTTACAACTGCGGGGCCACTGGTCACCGCGCCCAGGACTGCA AACAGCCGTCCATGGACTTCAACCGGCCAGGTACTTTTAGGTTGAAATACGCCCCTCCAGCAGAAAGTCTGGACTCCACAGATTGATATT TTTCTCTGGCAACAGAACGTTATTAAGCCATGGAGACATAAGGAAAATTAAATACAAAACTGAGAAGTCTAGTTGCTGTTGAGCTTAATC TTTTTAATCCAAAGGTGCTTTACTTTTCCTAGACTGGATAGAAAATCTAGCGTAGAAGTGCATCAAACTCGATTTATTGCCAAAACCCTA GATTGGAGCTTGGTGTCAGAACTCGCCTAGTGGGCATCTCTGTGGCTGGTGAGATCGGCCACCTCCACTTTTGGTTGCAGTGCAGAGACG CCATGTCTCCCGAAGAGCATTGCCATCACTGGCCCTCCTAGGCTCACACGTCAATTCCAGGGCAGCTACACGTGGTCTGAATCGAGAACC GAGCTTGGAGTTCTCCAAGTGGAGTTCCACCCGCCGGACTCCTGACACCCCTGGGCTAGGGAAAATGTCGACTTTGTTTTGTTCTGTTCC TAAAGTGATTAGCACTAATCTCTGGGATTTTTAAGGATTGCACTACAGAAGAATGTACCCTGATGTAAATCTCTGCGGTTCTGGGAGCCA AACTCCTCTGAGAACAGTCAGTGCAAGAGACTCCAATAATCCATATTGAAAGAGTCAGCACCAGCAGAGGCTACTCGACTTAGGACGCAA CAGAGGTTTTAGTATTTCCTTCCCTCCTCCAAGCACTTGTAGCAGTTTCAGGTTTTTAATTTTTTTCTGCAAATAAATCTAAACTACGTT ATTAAATAGAAATAGTTTACTCGCAACAACTTAATTTCTAAGGGTCCAAGTCCCAGAGAATCCATAGTCGTCAAAGCTTTGAGAGTATCT TTCTTCCCAGCCAGTCAGTGGCTTTGAGCCCTATCTTCCACTACAAATGACCTCTCGAGGGGGGACGGCGACAGCGCGGCTCTGTGAGTG GCTGTGAGGATGCTGCACGTCCTCAGCAGAGTTTGCAAGTTGCTTTATCTCCCACGGGCTCCCCAAGAACCTCCAACCCCGAGGCTTATC GCTAGCGGATTCACACCTGAGACAGACATTTCAACAATGATACAGTCCTGTCATTTATCAGCAAAAGATTGGGAATTTTCTCCTGTCAAC TTCTTTTGTATTAGGCTGTGTATTGATAGTTAATTCCGTTAAAAATTACTTGGAAAACAGTGGGAAGTGGTAGGACTCTGGAAGAGGCCA CACACCCGAGAGCTGCGAGATCTGTGCAAGTCTGGTTTTGGTTAGGTAGTAATAAAAGTCCTCACTGTAGATCTCTAAATTTCAACCCAC GGAAATGAAAGCCTTTTGTCTGAAATTTACGGACTTAAATCTTCAAGGTTAAAGGGAATTTTCTGCTCAAATAATACTCTTATCGAAAAT GCTAAAGTCTTCAATGTTAAAATACTGATTGGTAAAATCTTGCAGTTGGGATTTTGCAGTTGGATATTTATTTTAAAAAAAATTATAATA TTCAGACTATTCTTAAAATGGGACAATCAGCCTCATGAAAAATTGATGTAAATCAGAAGAATACCCTAGAATGAGGCCTTGTGATGTGAG CGTTCAATTTGAAGAGCAGTTCCTAACTTCATAGAAACTAAAGCAGAAAGTTGTTACATTTTTTTTATGACAGGCTTTTAGTAGAATTTT TTAGTTTTATTTTAGTTGAATTTTATTTCTATGCAATGCAGAATTAACAGACCTCTTCTCCTCATGGTACACAGTATTACAGTGTTGAAG TAATGGTGATGCTTATTACAACAGCTATTTAGGGGAATGTTACGTTGATCTCTTAAATTGTAAACACTACAAAATGTCAAAATAATGAGA ACTGACACAACTTTGCCTTAAAGAGTACTAGACTGGACCTTCTCATATTACGTTTAAGGAAGACTTAGAGTGTTCATTGATGTTTACGAT TTTAATATTTCTGAAGGCCATTACAGTGGCCTGGATATGTGCTGAAAGCCAAACTTTTAAATTTTTTGGTTTTTTTAAGCAAAGAAATAT TTTAAATAAATCCTATTTCAACACTGAAATTGTTGAAAACCGTCTCATAACAAAAGGAAAAAACATTGGAATTTTTGTTTTAGTGGTCAG TATAGGGGAATGAAAGCGTCTGTTGTTACCCACGTAACTATTTTGATAAGTATTAGAGGTTAACCTTAAATCCAGCAAAACATTAAAACA GAAACTTTTCAACTTGGAGCCTGCCATTCAGCGTTGAGGTAGATGAGTTCCGACACTGTCACGGCTGTGTTCCCAGCAGCGAAGGCCTCT GCGGAGCTGCCAGTCGTCTTGAACGTGCATGGGCGGCGTGTGACATCTCCAGGGAGGCCGTCCGAAGTCGAGAATCGTCAGCTGTAAGTA GGAGCTACACAGCGCAGAGAAAATGGAACCACCCATCCGTGAGGCCTCTTTCCGGAGGGAGCCGCACACTTGGACTTGAGAGTTTGCCAG CAGCGAGCTCGGATGCATCTCTCCAAAAGCCACCAAGGTCGGCGCGTCTGAAGAGCGTTTTGCGGTCATCAGACTTCCTCATCTGAAAAC ACAGAACATACTGACCCTTTCAAGTACTTAGTCATTTTCCTGAAAGTGTGGTCTGTTTCAGAATGCTGTGGCAACCAGGTAGGTGTGGCA CTGGCCATGTGCCACGTCTTTGCCCTTTGTAGTCTGTCAGATATTAAAGTTTCTAACCCTGTTTTTTTAATCTCCAAGAATGGGGAAAGT GGAATGTAGAGATGGAAGCAGAACGTGATGTTTGGATACAACAGCTATTTAATCCTTTTTTATTTTTTAAGCAAAACACTCAGTTTTCTA CCTTATTTTCTAATGTTGATTTCATGGTAATACTGACAGTTGGAAGTGTTTAACATAAAAACTCATTGCTAAAGAGCACTGAGGAAATGG GAGCTAGCGCACTTGTAATAAAAATAAAGACAAAATATTTTCTTGAATGCATATATGTGATTGGGTATTTTAAAAACCAGTATCATCTGT CATCTCCAAAAGATTACAGGAGTCAGCTTGTTAATACAGTAGTGTTAGTAGGTTCTGTATTTTTAATTCAGTACTTAGAATTCTAGGTCC TTTATTGCCCAAAGTCAGCACAGTTAGTTTATACCACAGACTCTGTCTTGGGGCACAGTAGTGGGGCGGGGTAGTGACTTTGCCTAAACA TCACCCAGCTGGAACAGAGGCTGAGCGGGGCTTTAGGCACTTGCCAGATGGGAACTGGGTTGCACCCTCCTTGCTCCCTGTCATTTTCTT GTCACTCTTCCTGCTTCCCAGTGTTTTATTTTATGCCTTGCTCGTTGTACATCATGATGACTGATGGTCTTCAAGGTTGTGAGGAAAGCC GTCTCCCTGCTTGACTCGACTGCTGTCCCAGAGGAGAGTCCTGTGCGACCTGAGCGGGGGTGGCTGCCATTTCCAGCATGCAGGTGACTT CCAAAGAATGAGTCAGGTGGCACTGAAAGCCATGGGTTCTGAAGAGGCGAATTTGTTGAAAAGTCCCAAGGGTCTGAATGAAAGCATCTT TAATCAACACTCAACACTCGCAATATTCTAGAAAACCATATACTGTGCTGGTTGAGGCCAAAGGTTAACATTGCTCCACTGTTCACCAAG GAAGGGGGCAGTGGCCATCCGCCGCGGCCTCACGTGCGTTGTAACAAGCCCTCATCACATGTGTGAGTCTTACGTGCACAAAAAGAGAAG GCTTTGGTACTGAAACTGGACACCTTGTGTACTCGATACCTTCACAGCTTCTATTGGACATATTTTCTTTTTAGGAATGAAGGAAAATTC TCCCATTTTTGAGCCATTCTTTTGTCAATTCTACAAAATTGCATGTAACTTTATAAATATTTTTAAAAGATATAGTTTTGTAAATATTTA ATATTCCGCTAATTTGATTTTGAATTGTAAATGTCAAGTATTCTGTTTTTGGGGTTTTTATGTTTTATTATACTTTGTTAAAAAGGACAA >42929_42929_2_KLHDC4-ZCCHC14_KLHDC4_chr16_87788800_ENST00000347925_ZCCHC14_chr16_87493737_ENST00000268616_length(amino acids)=1042AA_BP=1 MFPSGERGPFSFLVSRRGLGPGKMGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEEEDLEALIAHFQTLDAKRTQTVELPCPPPSPRLNA SLSVHPEKDELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQITPRTEAPVSSVSNSLENALHTSAHSTEESLPKR PLGKHSKVSVEKIDLKGLSHTKNDRNVECSFEVLWSDSSITSVTKSSSEVTEFISKLCQLYPEENLEKLIPCLAGPDAFYVERNHVDLDS GLRYLASLPSHVLKNDHVRRFLSTSSPPQQLQSPSPGNPSLSKVGTVMGVSGRPVCGVAGIPSSQSGAQHHGQHPAGSAAPLPHCSHAGS AGSALAYRTQMDTSPAILMPSSLQTPQTQEQNGILDWLRKLRLHKYYPVFKQLSMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEK SERRCLNPSAPPLVTSSGVARVPPTSHVGPVQSGRGSHAAELRVEVEQPHHQLPREGSSSEYSSSSSSPMGVQAREESSDSAEENDRRVE IHLESSDKEKPVMLLNHFTSSSARPTAQVLPVQNEASSNPSGHHPLPPQMLSAASHITPIRMLNSVHKPERGSADMKLLSSSVHSLLSLE ERNKGSGPRSSMKVDKSFGSAMMDVLPASAPHQPVQVLSGLSESSSMSPTVSFGPRTKVVHASTLDRVLKTAQQPALVVETSTAATGTPS TVLHAARPPIKLLLSSSVPADSAISGQTSCPNNVQISVPPAIINPRTALYTANTKVAFSAMSSMPVGPLQGGFCANSNTASPSSHPSTSF ANMATLPSCPAPSSSPALSSVPESSFYSSSGGGGSTGNIPASNPNHHHHHHHQQPPAPPQPAPPPPGCIVCTSCGCSGSCGSSGLTVSYA NYFQHPFSGPSVFTFPFLPFSPMCSSGYVSAQQYGGGSTFPVVHAPYSSSGTPDPVLSGQSTFAVPPMQNFMAGTAGVYQTQGLVGSSNG -------------------------------------------------------------- >42929_42929_3_KLHDC4-ZCCHC14_KLHDC4_chr16_87788800_ENST00000353170_ZCCHC14_chr16_87493737_ENST00000268616_length(transcript)=6932nt_BP=207nt CCCGGCAAGATGGGCAAGAAGGGCAAGAAGGAGAAGAAGGGCCGCGGCGCGGAGAAGACGGCCGCCAAGATGGAGAAGAAGGTGTCTAAG CGCTCGCGGAAGGAGGAGACTTTTTTGTATAACGAGCTCTATGTCTACAATACCAGAAAGGACACCTGGACCAAAGTTGACATCCCCAGT CCACCTCCGAGGCGCTGTGCTCACCAGATCACTCCAAGAACTGAGGCCCCTGTCAGCAGTGTCAGTAATAGTTTGGAGAATGCCCTGCAC ACATCAGCACATTCCACGGAGGAGTCGCTGCCCAAGAGGCCCTTAGGAAAACACAGCAAAGTGAGTGTTGAAAAGATAGACCTGAAGGGA TTATCACACACAAAAAATGACAGAAATGTTGAATGTTCCTTTGAGGTCTTGTGGTCTGATTCTTCAATAACATCAGTAACCAAATCTTCC TCTGAAGTGACGGAATTTATTTCAAAGCTATGTCAGCTCTATCCTGAAGAGAACTTGGAGAAACTCATTCCTTGCTTAGCTGGTCCGGAC GCATTTTATGTGGAGCGAAACCACGTGGATCTGGACTCAGGCCTGAGGTACCTGGCCTCATTACCTTCTCACGTGTTGAAAAATGACCAT GTCAGGAGGTTTCTCAGCACTTCCTCTCCCCCACAGCAGCTTCAGAGTCCAAGTCCTGGCAATCCCTCCCTTTCTAAAGTAGGTACCGTG ATGGGCGTGTCTGGAAGGCCTGTGTGTGGAGTGGCTGGTATCCCGTCCTCGCAGAGCGGAGCCCAGCACCACGGGCAGCACCCGGCCGGC TCCGCCGCCCCCTTGCCTCACTGCTCCCATGCGGGCAGCGCGGGCTCAGCCCTGGCCTACCGGACCCAGATGGACACATCACCTGCCATC CTCATGCCTTCCAGTCTGCAGACCCCTCAGACCCAGGAGCAGAATGGGATTCTAGACTGGCTTAGGAAACTGCGTTTGCACAAGTATTAC CCCGTCTTTAAGCAGCTCTCCATGGAGAAGTTTTTGAGCCTTACTGAAGAAGATCTGAATAAATTTGAGTCTCTTACCATGGGGGCAAAG AAGAAGCTCAAGACCCAGCTGGAGCTGGAAAAGGAGAAGTCAGAGAGACGGTGCCTGAACCCCTCGGCCCCGCCGCTGGTCACCAGCAGT GGTGTGGCTCGAGTGCCCCCCACCAGCCACGTCGGGCCCGTGCAGTCGGGGCGGGGCAGCCATGCAGCAGAGCTGCGGGTGGAAGTGGAG CAGCCCCATCACCAGCTGCCCCGGGAAGGCAGTTCCTCGGAGTACTCCAGCTCCTCCTCCAGCCCCATGGGGGTACAGGCCCGGGAAGAG AGCTCCGACAGCGCTGAGGAGAATGACAGACGTGTGGAGATTCACTTGGAGAGCTCTGACAAGGAGAAGCCGGTGATGCTGCTGAATCAC TTCACTTCCAGTTCCGCCAGACCCACGGCCCAGGTTCTCCCTGTGCAGAATGAGGCCAGCTCCAATCCATCAGGCCACCACCCCCTGCCC CCGCAGATGCTGAGCGCAGCCTCACACATCACACCCATCCGCATGCTGAATTCCGTGCACAAGCCGGAAAGAGGGAGCGCGGACATGAAG CTCCTCTCGTCTTCTGTGCACTCACTTTTGTCTCTAGAAGAAAGGAATAAAGGATCTGGACCAAGAAGCAGCATGAAAGTGGACAAGAGC TTTGGCAGCGCCATGATGGACGTGCTGCCCGCGTCCGCACCCCACCAGCCTGTGCAGGTCCTCTCTGGGCTTTCGGAGAGCAGCTCCATG TCACCCACAGTCTCCTTTGGTCCCCGGACCAAAGTCGTGCATGCATCCACGCTGGACAGGGTGCTGAAGACAGCACAGCAACCGGCCCTG GTCGTGGAGACCAGCACGGCCGCCACGGGGACGCCCAGCACAGTCCTCCACGCCGCCCGTCCGCCCATCAAACTGCTGCTGTCGTCATCT GTTCCTGCTGATTCTGCCATTTCTGGGCAAACTTCCTGTCCTAATAATGTGCAAATAAGTGTGCCCCCTGCAATAATAAACCCCCGGACT GCTCTGTACACAGCCAACACCAAAGTTGCCTTTTCTGCAATGAGCAGTATGCCAGTGGGCCCCCTGCAGGGTGGCTTCTGTGCAAACAGC AACACTGCCTCTCCCAGCAGCCACCCCTCCACGTCCTTTGCCAACATGGCCACGTTGCCCAGCTGCCCAGCCCCCAGCTCCAGCCCGGCG CTGTCCTCCGTCCCTGAAAGCAGTTTCTATAGCAGCAGTGGCGGTGGCGGCTCCACAGGAAACATTCCTGCCTCGAATCCGAACCACCAC CACCACCACCACCATCAGCAGCCCCCGGCACCCCCGCAGCCCGCCCCACCCCCGCCAGGCTGCATTGTGTGCACGTCCTGTGGCTGCAGC GGCAGCTGCGGCTCGAGTGGCCTGACTGTCAGCTACGCCAACTACTTCCAGCACCCGTTCTCCGGTCCGTCCGTGTTCACCTTCCCCTTC TTGCCCTTCAGTCCCATGTGCAGCAGCGGCTACGTCAGCGCCCAGCAGTACGGCGGCGGCTCCACCTTCCCCGTCGTGCACGCCCCTTAC AGCAGCAGCGGGACCCCAGACCCTGTCCTGAGTGGGCAGTCCACGTTTGCCGTGCCACCCATGCAGAACTTCATGGCAGGGACAGCAGGG GTGTACCAGACCCAAGGACTGGTGGGCAGTAGCAATGGTTCCAGTCACAAAAAGAGCGGGAACCTATCTTGTTACAACTGCGGGGCCACT GGTCACCGCGCCCAGGACTGCAAACAGCCGTCCATGGACTTCAACCGGCCAGGTACTTTTAGGTTGAAATACGCCCCTCCAGCAGAAAGT CTGGACTCCACAGATTGATATTTTTCTCTGGCAACAGAACGTTATTAAGCCATGGAGACATAAGGAAAATTAAATACAAAACTGAGAAGT CTAGTTGCTGTTGAGCTTAATCTTTTTAATCCAAAGGTGCTTTACTTTTCCTAGACTGGATAGAAAATCTAGCGTAGAAGTGCATCAAAC TCGATTTATTGCCAAAACCCTAGATTGGAGCTTGGTGTCAGAACTCGCCTAGTGGGCATCTCTGTGGCTGGTGAGATCGGCCACCTCCAC TTTTGGTTGCAGTGCAGAGACGCCATGTCTCCCGAAGAGCATTGCCATCACTGGCCCTCCTAGGCTCACACGTCAATTCCAGGGCAGCTA CACGTGGTCTGAATCGAGAACCGAGCTTGGAGTTCTCCAAGTGGAGTTCCACCCGCCGGACTCCTGACACCCCTGGGCTAGGGAAAATGT CGACTTTGTTTTGTTCTGTTCCTAAAGTGATTAGCACTAATCTCTGGGATTTTTAAGGATTGCACTACAGAAGAATGTACCCTGATGTAA ATCTCTGCGGTTCTGGGAGCCAAACTCCTCTGAGAACAGTCAGTGCAAGAGACTCCAATAATCCATATTGAAAGAGTCAGCACCAGCAGA GGCTACTCGACTTAGGACGCAACAGAGGTTTTAGTATTTCCTTCCCTCCTCCAAGCACTTGTAGCAGTTTCAGGTTTTTAATTTTTTTCT GCAAATAAATCTAAACTACGTTATTAAATAGAAATAGTTTACTCGCAACAACTTAATTTCTAAGGGTCCAAGTCCCAGAGAATCCATAGT CGTCAAAGCTTTGAGAGTATCTTTCTTCCCAGCCAGTCAGTGGCTTTGAGCCCTATCTTCCACTACAAATGACCTCTCGAGGGGGGACGG CGACAGCGCGGCTCTGTGAGTGGCTGTGAGGATGCTGCACGTCCTCAGCAGAGTTTGCAAGTTGCTTTATCTCCCACGGGCTCCCCAAGA ACCTCCAACCCCGAGGCTTATCGCTAGCGGATTCACACCTGAGACAGACATTTCAACAATGATACAGTCCTGTCATTTATCAGCAAAAGA TTGGGAATTTTCTCCTGTCAACTTCTTTTGTATTAGGCTGTGTATTGATAGTTAATTCCGTTAAAAATTACTTGGAAAACAGTGGGAAGT GGTAGGACTCTGGAAGAGGCCACACACCCGAGAGCTGCGAGATCTGTGCAAGTCTGGTTTTGGTTAGGTAGTAATAAAAGTCCTCACTGT AGATCTCTAAATTTCAACCCACGGAAATGAAAGCCTTTTGTCTGAAATTTACGGACTTAAATCTTCAAGGTTAAAGGGAATTTTCTGCTC AAATAATACTCTTATCGAAAATGCTAAAGTCTTCAATGTTAAAATACTGATTGGTAAAATCTTGCAGTTGGGATTTTGCAGTTGGATATT TATTTTAAAAAAAATTATAATATTCAGACTATTCTTAAAATGGGACAATCAGCCTCATGAAAAATTGATGTAAATCAGAAGAATACCCTA GAATGAGGCCTTGTGATGTGAGCGTTCAATTTGAAGAGCAGTTCCTAACTTCATAGAAACTAAAGCAGAAAGTTGTTACATTTTTTTTAT GACAGGCTTTTAGTAGAATTTTTTAGTTTTATTTTAGTTGAATTTTATTTCTATGCAATGCAGAATTAACAGACCTCTTCTCCTCATGGT ACACAGTATTACAGTGTTGAAGTAATGGTGATGCTTATTACAACAGCTATTTAGGGGAATGTTACGTTGATCTCTTAAATTGTAAACACT ACAAAATGTCAAAATAATGAGAACTGACACAACTTTGCCTTAAAGAGTACTAGACTGGACCTTCTCATATTACGTTTAAGGAAGACTTAG AGTGTTCATTGATGTTTACGATTTTAATATTTCTGAAGGCCATTACAGTGGCCTGGATATGTGCTGAAAGCCAAACTTTTAAATTTTTTG GTTTTTTTAAGCAAAGAAATATTTTAAATAAATCCTATTTCAACACTGAAATTGTTGAAAACCGTCTCATAACAAAAGGAAAAAACATTG GAATTTTTGTTTTAGTGGTCAGTATAGGGGAATGAAAGCGTCTGTTGTTACCCACGTAACTATTTTGATAAGTATTAGAGGTTAACCTTA AATCCAGCAAAACATTAAAACAGAAACTTTTCAACTTGGAGCCTGCCATTCAGCGTTGAGGTAGATGAGTTCCGACACTGTCACGGCTGT GTTCCCAGCAGCGAAGGCCTCTGCGGAGCTGCCAGTCGTCTTGAACGTGCATGGGCGGCGTGTGACATCTCCAGGGAGGCCGTCCGAAGT CGAGAATCGTCAGCTGTAAGTAGGAGCTACACAGCGCAGAGAAAATGGAACCACCCATCCGTGAGGCCTCTTTCCGGAGGGAGCCGCACA CTTGGACTTGAGAGTTTGCCAGCAGCGAGCTCGGATGCATCTCTCCAAAAGCCACCAAGGTCGGCGCGTCTGAAGAGCGTTTTGCGGTCA TCAGACTTCCTCATCTGAAAACACAGAACATACTGACCCTTTCAAGTACTTAGTCATTTTCCTGAAAGTGTGGTCTGTTTCAGAATGCTG TGGCAACCAGGTAGGTGTGGCACTGGCCATGTGCCACGTCTTTGCCCTTTGTAGTCTGTCAGATATTAAAGTTTCTAACCCTGTTTTTTT AATCTCCAAGAATGGGGAAAGTGGAATGTAGAGATGGAAGCAGAACGTGATGTTTGGATACAACAGCTATTTAATCCTTTTTTATTTTTT AAGCAAAACACTCAGTTTTCTACCTTATTTTCTAATGTTGATTTCATGGTAATACTGACAGTTGGAAGTGTTTAACATAAAAACTCATTG CTAAAGAGCACTGAGGAAATGGGAGCTAGCGCACTTGTAATAAAAATAAAGACAAAATATTTTCTTGAATGCATATATGTGATTGGGTAT TTTAAAAACCAGTATCATCTGTCATCTCCAAAAGATTACAGGAGTCAGCTTGTTAATACAGTAGTGTTAGTAGGTTCTGTATTTTTAATT CAGTACTTAGAATTCTAGGTCCTTTATTGCCCAAAGTCAGCACAGTTAGTTTATACCACAGACTCTGTCTTGGGGCACAGTAGTGGGGCG GGGTAGTGACTTTGCCTAAACATCACCCAGCTGGAACAGAGGCTGAGCGGGGCTTTAGGCACTTGCCAGATGGGAACTGGGTTGCACCCT CCTTGCTCCCTGTCATTTTCTTGTCACTCTTCCTGCTTCCCAGTGTTTTATTTTATGCCTTGCTCGTTGTACATCATGATGACTGATGGT CTTCAAGGTTGTGAGGAAAGCCGTCTCCCTGCTTGACTCGACTGCTGTCCCAGAGGAGAGTCCTGTGCGACCTGAGCGGGGGTGGCTGCC ATTTCCAGCATGCAGGTGACTTCCAAAGAATGAGTCAGGTGGCACTGAAAGCCATGGGTTCTGAAGAGGCGAATTTGTTGAAAAGTCCCA AGGGTCTGAATGAAAGCATCTTTAATCAACACTCAACACTCGCAATATTCTAGAAAACCATATACTGTGCTGGTTGAGGCCAAAGGTTAA CATTGCTCCACTGTTCACCAAGGAAGGGGGCAGTGGCCATCCGCCGCGGCCTCACGTGCGTTGTAACAAGCCCTCATCACATGTGTGAGT CTTACGTGCACAAAAAGAGAAGGCTTTGGTACTGAAACTGGACACCTTGTGTACTCGATACCTTCACAGCTTCTATTGGACATATTTTCT TTTTAGGAATGAAGGAAAATTCTCCCATTTTTGAGCCATTCTTTTGTCAATTCTACAAAATTGCATGTAACTTTATAAATATTTTTAAAA GATATAGTTTTGTAAATATTTAATATTCCGCTAATTTGATTTTGAATTGTAAATGTCAAGTATTCTGTTTTTGGGGTTTTTATGTTTTAT TATACTTTGTTAAAAAGGACAAATTGTACATTTTTAGAATGTTTTTATGAGTAAATTTAATGTACTGAAAATAAAAATTTTAAAAAAGGC >42929_42929_3_KLHDC4-ZCCHC14_KLHDC4_chr16_87788800_ENST00000353170_ZCCHC14_chr16_87493737_ENST00000268616_length(amino acids)=962AA_BP=0 MGKKGKKEKKGRGAEKTAAKMEKKVSKRSRKEETFLYNELYVYNTRKDTWTKVDIPSPPPRRCAHQITPRTEAPVSSVSNSLENALHTSA HSTEESLPKRPLGKHSKVSVEKIDLKGLSHTKNDRNVECSFEVLWSDSSITSVTKSSSEVTEFISKLCQLYPEENLEKLIPCLAGPDAFY VERNHVDLDSGLRYLASLPSHVLKNDHVRRFLSTSSPPQQLQSPSPGNPSLSKVGTVMGVSGRPVCGVAGIPSSQSGAQHHGQHPAGSAA PLPHCSHAGSAGSALAYRTQMDTSPAILMPSSLQTPQTQEQNGILDWLRKLRLHKYYPVFKQLSMEKFLSLTEEDLNKFESLTMGAKKKL KTQLELEKEKSERRCLNPSAPPLVTSSGVARVPPTSHVGPVQSGRGSHAAELRVEVEQPHHQLPREGSSSEYSSSSSSPMGVQAREESSD SAEENDRRVEIHLESSDKEKPVMLLNHFTSSSARPTAQVLPVQNEASSNPSGHHPLPPQMLSAASHITPIRMLNSVHKPERGSADMKLLS SSVHSLLSLEERNKGSGPRSSMKVDKSFGSAMMDVLPASAPHQPVQVLSGLSESSSMSPTVSFGPRTKVVHASTLDRVLKTAQQPALVVE TSTAATGTPSTVLHAARPPIKLLLSSSVPADSAISGQTSCPNNVQISVPPAIINPRTALYTANTKVAFSAMSSMPVGPLQGGFCANSNTA SPSSHPSTSFANMATLPSCPAPSSSPALSSVPESSFYSSSGGGGSTGNIPASNPNHHHHHHHQQPPAPPQPAPPPPGCIVCTSCGCSGSC GSSGLTVSYANYFQHPFSGPSVFTFPFLPFSPMCSSGYVSAQQYGGGSTFPVVHAPYSSSGTPDPVLSGQSTFAVPPMQNFMAGTAGVYQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KLHDC4-ZCCHC14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KLHDC4-ZCCHC14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KLHDC4-ZCCHC14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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