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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC4-RTN4 (FusionGDB2 ID:4293)

Fusion Gene Summary for ANAPC4-RTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC4-RTN4
Fusion gene ID: 4293
HgeneTgene
Gene symbol

ANAPC4

RTN4

Gene ID

29945

57142

Gene nameanaphase promoting complex subunit 4reticulon 4
SynonymsAPC4ASY|NI220/250|NOGO|NSP|NSP-CL|Nbla00271|Nbla10545|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C
Cytomap

4p15.2

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 4cyclosome subunit 4reticulon-4Human NogoAMy043 proteinfoocenneurite growth inhibitor 220neurite outgrowth inhibitorneuroendocrine-specific protein C homologreticulon 5
Modification date2020031320200327
UniProtAcc

Q9UJX5

.
Ensembl transtripts involved in fusion geneENST00000315368, ENST00000510092, 
ENST00000354474, ENST00000402434, 
ENST00000486085, ENST00000317610, 
ENST00000337526, ENST00000357376, 
ENST00000357732, ENST00000394609, 
ENST00000394611, ENST00000404909, 
ENST00000405240, 
Fusion gene scores* DoF score4 X 4 X 2=3227 X 28 X 9=6804
# samples 435
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(35/6804*10)=-4.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC4 [Title/Abstract] AND RTN4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC4(25419961)-RTN4(55209717), # samples:1
RTN4(55209717)-ANAPC4(25419961), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC4

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneRTN4

GO:0030517

negative regulation of axon extension

10667797

TgeneRTN4

GO:0071787

endoplasmic reticulum tubular network formation

24262037|25612671

TgeneRTN4

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

27353365


check buttonFusion gene breakpoints across ANAPC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AW68688ANAPC4chr4

25419961

-RTN4chr2

55209717

+


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Fusion Gene ORF analysis for ANAPC4-RTN4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000315368ENST00000354474ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000315368ENST00000402434ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000315368ENST00000486085ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000510092ENST00000354474ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000510092ENST00000402434ANAPC4chr4

25419961

-RTN4chr2

55209717

+
5CDS-5UTRENST00000510092ENST00000486085ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000317610ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000337526ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000357376ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000357732ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000394609ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000394611ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000404909ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000315368ENST00000405240ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000317610ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000337526ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000357376ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000357732ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000394609ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000394611ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000404909ANAPC4chr4

25419961

-RTN4chr2

55209717

+
In-frameENST00000510092ENST00000405240ANAPC4chr4

25419961

-RTN4chr2

55209717

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315368ANAPC4chr425419961-ENST00000394609RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000405240RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000357376RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000317610RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000357732RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000337526RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000394611RTN4chr255209717+375325001422349735
ENST00000315368ANAPC4chr425419961-ENST00000404909RTN4chr255209717+375325001422349735
ENST00000510092ANAPC4chr425419961-ENST00000394609RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000405240RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000357376RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000317610RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000357732RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000337526RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000394611RTN4chr255209717+36672414622272736
ENST00000510092ANAPC4chr425419961-ENST00000404909RTN4chr255209717+36672414622272736

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315368ENST00000394609ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000405240ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000357376ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000317610ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000357732ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000337526ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000394611ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000315368ENST00000404909ANAPC4chr425419961-RTN4chr255209717+0.00045330.9995467
ENST00000510092ENST00000394609ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000405240ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000357376ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000317610ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000357732ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000337526ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000394611ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436
ENST00000510092ENST00000404909ANAPC4chr425419961-RTN4chr255209717+0.0005563930.9994436

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Fusion Genomic Features for ANAPC4-RTN4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANAPC4-RTN4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:25419961/chr2:55209717)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC4

Q9UJX5

.
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRTN4chr4:25419961chr2:55209717ENST0000031761007143_1480374.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000003176100730_470374.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000033752609143_14801193.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000003375260930_4701193.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000035737609143_1480987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000003573760930_470987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000035773208143_1480393.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000003577320830_470393.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000039460907143_1480200.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000003946090730_470200.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000039461109143_1480987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000003946110930_470987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000040490909143_1480987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000004049090930_470987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST0000040524009143_1480987.0Compositional biasNote=Poly-Pro
TgeneRTN4chr4:25419961chr2:55209717ENST000004052400930_470987.0Compositional biasNote=Poly-Glu
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610071005_11920374.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526091005_119201193.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376091005_11920987.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732081005_11920393.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609071005_11920200.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611091005_11920987.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909091005_11920987.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240091005_11920987.0DomainReticulon
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610071040_11330374.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610071155_11920374.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610071_10180374.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526091040_113301193.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526091155_119201193.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526091_101801193.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376091040_11330987.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376091155_11920987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376091_10180987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732081040_11330393.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732081155_11920393.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732081_10180393.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609071040_11330200.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609071155_11920200.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609071_10180200.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611091040_11330987.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611091155_11920987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611091_10180987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909091040_11330987.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909091155_11920987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909091_10180987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240091040_11330987.0Topological domainLumenal
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240091155_11920987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240091_10180987.0Topological domainCytoplasmic
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610071019_10390374.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000317610071134_11540374.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526091019_103901193.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000337526091134_115401193.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376091019_10390987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357376091134_11540987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732081019_10390393.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000357732081134_11540393.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609071019_10390200.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394609071134_11540200.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611091019_10390987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000394611091134_11540987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909091019_10390987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000404909091134_11540987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240091019_10390987.0TransmembraneHelical
TgeneRTN4chr4:25419961chr2:55209717ENST00000405240091134_11540987.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANAPC4-RTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4293_4293_1_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000317610_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_1_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000317610_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_2_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000337526_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_2_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000337526_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_3_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000357376_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_3_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000357376_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_4_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000357732_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_4_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000357732_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_5_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000394609_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_5_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000394609_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_6_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000394611_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_6_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000394611_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_7_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000404909_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_7_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000404909_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_8_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000405240_length(transcript)=3753nt_BP=2500nt
CCCGACGCCGGAAGTGCCTGGAGCGCGCGACAGCGGCGGGGCGGGGCGGCCTGGAGGCTGTGGCGCGCGGCCGGCAGAGGGAGGGGAGAG
GCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCATCCTTCCGGGT
GGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACACAGCTGGCGA
GGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGTGTCTGGCATG
GAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGAGCTTACACTC
TTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATAATGCTGAGGA
TGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAAATTCTGATGA
AATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTTATGGAATGTT
TAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGGTCACAGAAGT
CTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTCGGATGGCCAG
AAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATACTAATGCAGAT
GGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTATGGGGGAAAGC
AAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCATCATACTCCAG
TATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGGCTTCATGGAA
GCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGGCAAATGAACT
TCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAGAAGACCATGT
GCTTCCCGAGCTGAATAAGATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGGCTCCAGACCTTTA
TAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCACCCCCTAACACAGA
AGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTCGAAAATCATTGCA
TTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGAATCAAGCAATCTG
TATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATAAAACTTCAAATCT
ACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTCAATCTGTGAGTAA
TGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTTTAGATGCACAGTT
TTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGCTGCCTTTGTCTTT
AGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTGCTATTCCCACCCG
TACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAAAAGTGTCCTGTGT
GAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGGCCAAAAGGACATA
GGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTATTTTTTCAAATCCAAGCAAAAATCCCTG
GATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGGGAGG
GTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGGAAAA
ATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTCCTAT
CTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGATGGTG
GAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAAATGT
TTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGTTATA
TTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTGCTTG
ATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCATCTGT
TTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTATGGA
CTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATTTATA
CCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTTAAAA
GCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTGTTAT
TTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGGTGTG

>4293_4293_8_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000315368_RTN4_chr2_55209717_ENST00000405240_length(amino acids)=735AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKMTQKDITFVAE
FLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTEK
VRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ

--------------------------------------------------------------
>4293_4293_9_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000317610_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_9_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000317610_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_10_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000337526_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_10_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000337526_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_11_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000357376_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_11_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000357376_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_12_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000357732_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_12_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000357732_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_13_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000394609_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_13_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000394609_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_14_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000394611_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_14_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000394611_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_15_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000404909_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_15_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000404909_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------
>4293_4293_16_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000405240_length(transcript)=3667nt_BP=2414nt
GAGGGGAGAGGCCACTGGGGCCGTGTTAGTCTGCCGGTGGGGACTCTTGCAGGGCCGTCCCCATGTTGCGTTTTCCGACCTGTTTCCCAT
CCTTCCGGGTGGTGGGAGAGAAGCAGCTCCCGCAGGAGATTATTTTCCTGGTCTGGTCGCCCAAGCGGGATCTCATTGCTTTGGCCAACA
CAGCTGGCGAGGTTTTACTTCATCGACTGGCAAGTTTTCATCGAGTTTGGAGTTTTCCACCAAATGAAAATACAGGAAAGGAGGTGACGT
GTCTGGCATGGAGACCAGATGGCAAACTTTTGGCCTTTGCTCTTGCTGATACCAAGAAAATTGTTTTGTGTGATGTAGAAAAACCTGAGA
GCTTACACTCTTTTTCTGTGGAGGCTCCAGTTTCCTGTATGCATTGGATGGAAGTGACAGTAGAAAGCAGTGTTCTCACATCATTTTATA
ATGCTGAGGATGAATCAAATCTTCTCTTACCTAAACTACCTACACTGCCAAAAAACTATAGCAACACCTCAAAAATATTTAGTGAAGAAA
ATTCTGATGAAATTATTAAGCTCTTGGGAGACGTCAGGCTTAATATTCTCGTCCTTGGAGGAAGCTCTGGATTTATTGAGCTTTATGCTT
ATGGAATGTTTAAAATTGCTCGAGTCACAGGGATTGCTGGTACTTGTCTTGCATTATGTTTATCAAGTGATTTGAAATCATTATCAGTGG
TCACAGAAGTCTCTACCAATGGTGCTTCAGAAGTTTCATACTTTCAGCTTGAAACTAATCTGTTGTACTCTTTCTTACCTGAAGTAACTC
GGATGGCCAGAAAGTTTACTCATATTTCAGCTCTGTTACAGTATATAAATTTGTCACTAACATGTATGTGTGAAGCATGGGAAGAAATAC
TAATGCAGATGGATTCTCGTCTCACCAAGTTTGTGCAGGAAAAGAACACAACCACATCAGTGCAAGATGAGTTCATGCACTTGCTATTAT
GGGGGAAAGCAAGTGCTGAACTTCAGACTCTCTTGATGAATCAGTTAACAGTAAAGGGCTTGAAAAAGCTTGGCCAGTCTATAGAGTCAT
CATACTCCAGTATACAAAAATTGGTCATAAGTCATTTACAGAGTGGCTCGGAGTCTTTATTATACCATTTGAGTGAATTGAAAGGAATGG
CTTCATGGAAGCAAAAATATGAACCTCTTGGACTAGATGCTGCAGGAATCGAAGAAGCTATAACTGCTGTGGGTTCTTTTATACTCAAGG
CAAATGAACTTCTTCAAGTTATAGATAGTAGTATGAAAAACTTCAAAGCATTTTTTCGGTGGCTTTATGTGGCAATGTTGAGAATGACAG
AAGACCATGTGCTTCCCGAGCTGAATAAGGTAATGACTCAGAAAGATATCACATTTGTTGCTGAATTTCTTACTGAACATTTCAATGAGG
CTCCAGACCTTTATAATCGAAAAGGAAAATACTTTAACGTTGAAAGAGTTGGTCAGTACTTGAAAGATGAAGATGATGATCTTGTGTCAC
CCCCTAACACAGAAGGAAACCAGTGGTATGACTTTCTTCAAAATAGCAGCCACCTTAAAGAAAGTCCTTTGCTGTTTCCTTATTATCCTC
GAAAATCATTGCATTTTGTGAAAAGGCGGATGGAGAATATTATTGATCAGTGTTTGCAAAAGCCAGCAGATGTAATTGGAAAATCGATGA
ATCAAGCAATCTGTATTCCATTGTATAGAGATACCAGAAGTGAGGATTCTACACGTAGATTGTTCAAATTTCCTTTTCTGTGGAATAATA
AAACTTCAAATCTACATTATCTTCTTTTTACTATTCTAGAAGATTCACTTTATAAAATGTGCATCTTAAGGAGACATACTGATATTTCTC
AATCTGTGAGTAATGGACTAATTGCTATTAAATTTGGGAGCTTTACATATGCCACAACAGAAAAAGTCAGAAGAAGCATCTACAGTTGTT
TAGATGCACAGTTTTATGATGATGAAACTGTAACAGTAGTTCTTAAAGACACTGTAGGACGTGAAGGAAGAGATAGACTCTTGGTCCAGC
TGCCTTTGTCTTTAGTATATAACAGTGAAGATTCTGCAGAATATCAGTTCACTGGGACTTATTCTACAAGGCTAGATGAACAGTGTAGTG
CTATTCCCACCCGTACCATGCATTTTGAGAAGCACTGGAGATTACTGGAAAGTATGAAAGCACAGTATGTTGCTGGGAATGGTTTTCGAA
AAGTGTCCTGTGTGAGTCATTAAAGTGGAAAAACTTGACCCTGAGCTAGACTCCTAATCTAGCTTGCCATTATTGTGTGTGTAATTATGG
CCAAAAGGACATAGGAGATGGACTAAGATGTCTTGGACCACCTTTGTGTAACAAAGAAATAAACAGTAAATTTTAATCCAAGCAAAAATC
CCTGGATTGAAGCGCAAAGCTGAATGAAAACGCCCAAAATAATTAGTAGGAGTTCATCTTTAAAGGGGATATTCATTTGATTATACGGGG
GAGGGTCAGGGAAGAACGAACCTTGACGTTGCAGTGCAGTTTCACAGATCGTTGTTAGATCTTTATTTTTAGCCATGCACTGTTGTGAGG
AAAAATTACCTGTCTTGACTGCCATGTGTTCATCATCTTAAGTATTGTAAGCTGCTATGTATGGATTTAAACCGTAATCATATCTTTTTC
CTATCTATCTGAGGCACTGGTGGAATAAAAAACCTGTATATTTTACTTTGTTGCAGATAGTCTTGCCGCATCTTGGCAAGTTGCAGAGAT
GGTGGAGCTAGAAAAAAAAAAAAAAAAGCCCTTTTCAGTTTGTGCACTGTGTATGGTCCGTGTAGATTGATGCAGATTTTCTGAAATGAA
ATGTTTGTTTAGACGAGATCATACCGGTAAAGCAGGAATGACAAAGCTTGCTTTTCTGGTATGTTCTAGGTGTATTGTGACTTTTACTGT
TATATTAATTGCCAATATAAGTAAATATAGATTATATATGTATAGTGTTTCACAAAGCTTAGACCTTTACCTTCCAGCCACCCCACAGTG
CTTGATATTTCAGAGTCAGTCATTGGTTATACATGTGTAGTTCCAAAGCACATAAGCTAGAAGAAGAAATATTTCTAGGAGCACTACCAT
CTGTTTTCAACATGAAATGCCACACACATAGAACTCCAACATCAATTTCATTGCACAGACTGACTGTAGTTAATTTTGTCACAGAATCTA
TGGACTGAATCTAATGCTTCCAAAAATGTTGTTTGTTTGCAAATATCAAACATTGTTATGCAAGAAATTATTAATTACAAAATGAAGATT
TATACCATTGTGGTTTAAGCTGTACTGAACTAAATCTGTGGAATGCATTGTGAACTGTAAAAGCAAAGTATCAATAAAGCTTATAGACTT
AAAAGCACAGATAGATCATTATCTAGGACTTGCAAATAAGAATGTTAAAGATGCTATGGCTAACTCTCATTTCACTCTTCAGTGTTCCTG
TTATTTATGAACGGCATCAGTTTGCAGTGTTGATGTGGGTATTTACCTATGTTGGTGCCTTGTTTAATGGTCTGACACTACTGATTTTGG

>4293_4293_16_ANAPC4-RTN4_ANAPC4_chr4_25419961_ENST00000510092_RTN4_chr2_55209717_ENST00000405240_length(amino acids)=736AA_BP=
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALADTKKI
VLCDVEKPESLHSFSVEAPVSCMHWMEVTVESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNLLYSFLPEVTRMARKFTHISALLQYINLSLT
CMCEAWEEILMQMDSRLTKFVQEKNTTTSVQDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRWLYVAMLRMTEDHVLPELNKVMTQKDITFVA
EFLTEHFNEAPDLYNRKGKYFNVERVGQYLKDEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQK
PADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCILRRHTDISQSVSNGLIAIKFGSFTYATTE
KVRRSIYSCLDAQFYDDETVTVVLKDTVGREGRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANAPC4-RTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC4-RTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC4-RTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource