Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLHL20-DARS2 (FusionGDB2 ID:42953)

Fusion Gene Summary for KLHL20-DARS2

Fusion gene summary

Fusion gene information	Fusion gene name: KLHL20-DARS2
	Fusion gene ID: 42953
		Hgene	Tgene
	Gene symbol	KLHL20	DARS2
	Gene ID	27252	55157
	Gene name	kelch like family member 20	aspartyl-tRNA synthetase 2, mitochondrial
	Synonyms	KHLHX\|KLEIP\|KLHLX	ASPRS\|LBSL\|MT-ASPRS\|mtAspRS
	Cytomap	1q25.1	1q25.1
	Type of gene	protein-coding	protein-coding
	Description	kelch-like protein 20Kelch motif containing proteinkelch-like ECT2-interacting proteinkelch-like protein X	aspartate--tRNA ligase, mitochondrialaspartate tRNA ligase 2, mitochondrialaspartyl-tRNA synthetase, mitochondrial
	Modification date	20200327	20200313
	UniProtAcc	Q9Y2M5	Q6PI48
	Ensembl transtripts involved in fusion gene	ENST00000493170, ENST00000209884, ENST00000546011,	ENST00000361951, ENST00000471476, ENST00000239457,
Fusion gene scores	* DoF score	2 X 3 X 3=18	6 X 6 X 8=288
	# samples	3	9
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KLHL20 [Title/Abstract] AND DARS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLHL20(173703425)-DARS2(173819464), # samples:1 KLHL20(173721061)-DARS2(173825803), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KLHL20	GO:0016567	protein ubiquitination	20389280
Hgene	KLHL20	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	20389280
Hgene	KLHL20	GO:1990390	protein K33-linked ubiquitination	24768539
Tgene	DARS2	GO:0043039	tRNA aminoacylation	15779907\|17384640
Tgene	DARS2	GO:0070145	mitochondrial asparaginyl-tRNA aminoacylation	23275545

Fusion gene breakpoints across KLHL20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L7-A56G	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
ChimerDB4	OV	TCGA-13-0897	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+

Top

Fusion Gene ORF analysis for KLHL20-DARS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000493170	ENST00000361951	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
3UTR-3UTR	ENST00000493170	ENST00000471476	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
3UTR-5UTR	ENST00000493170	ENST00000239457	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
5CDS-3UTR	ENST00000209884	ENST00000471476	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
5CDS-3UTR	ENST00000209884	ENST00000471476	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
5CDS-3UTR	ENST00000546011	ENST00000471476	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
5CDS-5UTR	ENST00000209884	ENST00000239457	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
In-frame	ENST00000209884	ENST00000239457	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
In-frame	ENST00000209884	ENST00000361951	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
In-frame	ENST00000209884	ENST00000361951	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
In-frame	ENST00000546011	ENST00000239457	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
In-frame	ENST00000546011	ENST00000361951	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
intron-3CDS	ENST00000493170	ENST00000239457	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
intron-3CDS	ENST00000493170	ENST00000361951	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
intron-3CDS	ENST00000546011	ENST00000361951	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
intron-3UTR	ENST00000493170	ENST00000471476	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+
intron-3UTR	ENST00000546011	ENST00000471476	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+
intron-5UTR	ENST00000546011	ENST00000239457	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000209884

KLHL20

chr1

173703425

ENST00000361951

DARS2

chr1

173819464

2321

733

136

1479

447

ENST00000546011

KLHL20

chr1

173721061

ENST00000361951

DARS2

chr1

173825803

1437

332

143

595

150

ENST00000546011

KLHL20

chr1

173721061

ENST00000239457

DARS2

chr1

173825803

1435

332

143

595

150

ENST00000209884

KLHL20

chr1

173721061

ENST00000361951

DARS2

chr1

173825803

1997

892

136

1155

339

ENST00000209884

KLHL20

chr1

173721061

ENST00000239457

DARS2

chr1

173825803

1995

892

136

1155

339

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000209884	ENST00000361951	KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+	0.001131697	0.99886835
ENST00000546011	ENST00000361951	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+	0.003000847	0.99699914
ENST00000546011	ENST00000239457	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+	0.003004423	0.99699557
ENST00000209884	ENST00000361951	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+	0.001718007	0.9982821
ENST00000209884	ENST00000239457	KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+	0.001711009	0.9982889

Top

Fusion Genomic Features for KLHL20-DARS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+	0.000262197	0.9997378
KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+	8.24E-05	0.9999176
KLHL20	chr1	173703425	+	DARS2	chr1	173819464	+	0.000262197	0.9997378
KLHL20	chr1	173721061	+	DARS2	chr1	173825803	+	8.24E-05	0.9999176

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KLHL20-DARS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:173703425/chr1:173819464)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLHL20 Q9Y2M5	DARS2 Q6PI48
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486). {ECO:0000269\|PubMed:14528312, ECO:0000269\|PubMed:17395875, ECO:0000269\|PubMed:20389280, ECO:0000269\|PubMed:21670212, ECO:0000269\|PubMed:21840486, ECO:0000269\|PubMed:24768539}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

68_135

199

610.0

Domain

BTB

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

68_135

252

610.0

Domain

BTB

Tgene

DARS2

chr1:173703425

chr1:173819464

ENST00000361951

584_587

397

646.0

Nucleotide binding

ATP

Tgene

DARS2

chr1:173721061

chr1:173825803

ENST00000361951

584_587

558

646.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

170_272

199

610.0

Domain

Note=BACK

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

170_272

252

610.0

Domain

Note=BACK

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

319_365

199

610.0

Repeat

Note=Kelch 1

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

367_413

199

610.0

Repeat

Note=Kelch 2

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

414_460

199

610.0

Repeat

Note=Kelch 3

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

462_507

199

610.0

Repeat

Note=Kelch 4

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

509_554

199

610.0

Repeat

Note=Kelch 5

Hgene

KLHL20

chr1:173703425

chr1:173819464

ENST00000209884

556_601

199

610.0

Repeat

Note=Kelch 6

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

319_365

252

610.0

Repeat

Note=Kelch 1

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

367_413

252

610.0

Repeat

Note=Kelch 2

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

414_460

252

610.0

Repeat

Note=Kelch 3

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

462_507

252

610.0

Repeat

Note=Kelch 4

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

509_554

252

610.0

Repeat

Note=Kelch 5

Hgene

KLHL20

chr1:173721061

chr1:173825803

ENST00000209884

556_601

252

610.0

Repeat

Note=Kelch 6

Tgene

DARS2

chr1:173703425

chr1:173819464

ENST00000361951

266_268

397

646.0

Nucleotide binding

ATP

Tgene

DARS2

chr1:173721061

chr1:173825803

ENST00000361951

266_268

558

646.0

Nucleotide binding

ATP

Tgene

DARS2

chr1:173703425

chr1:173819464

ENST00000361951

244_247

397

646.0

Region

Aspartate

Tgene

DARS2

chr1:173721061

chr1:173825803

ENST00000361951

244_247

558

646.0

Region

Aspartate

Top

Fusion Gene Sequence for KLHL20-DARS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42953_42953_1_KLHL20-DARS2_KLHL20_chr1_173703425_ENST00000209884_DARS2_chr1_173819464_ENST00000361951_length(transcript)=2321nt_BP=733nt
CTGCCTGCGTTAGCGGCGGTGGAGGAGGAGGCAGAGAGGAGTGGAGGGCGGAGTAGACGGAGGAGGCTGCTGCAGAGAAGAAAGTGTCAG
AGCCGGTTCGGCTTTAGAGTGTGGTGAAGGGTACTTTTCATGGTGCATGGAAGGAAAGCCAATGCGCAGGTGTACCAACATTCGACCAGG
AGAGACTGGAATGGATGTAACAAGCCGCTGCACCCTTGGAGACCCCAACAAACTGCCAGAAGGGGTTCCCCAACCTGCCCGCATGCCCTA
TATCTCAGACAAGCACCCTCGACAAACCTTGGAAGTGATTAACCTTCTGAGAAAGCACCGGGAGCTATGTGATGTGGTGCTAGTTGTGGG
CGCCAAGAAGATATATGCCCATCGAGTCATTTTGTCAGCCTGTAGTCCCTACTTCCGAGCTATGTTTACAGGAGAATTGGCAGAGAGCCG
TCAGACAGAAGTAGTGATCCGAGACATTGACGAGAGGGCTATGGAATTACTGATTGACTTTGCGTATACCTCCCAGATAACAGTAGAAGA
GGGCAATGTTCAGACTCTTCTGCCAGCTGCTTGCCTCCTCCAGCTGGCAGAAATACAGGAAGCCTGCTGTGAATTCTTAAAGAGACAATT
AGATCCTTCTAACTGCCTGGGCATTCGGGCTTTTGCTGACACACATTCATGTCGTGAGTTGCTAAGGATAGCAGACAAGTTCACCCAACA
TAACTTTCAAGAGGAAATCTTACCTGTATTCCTTAACGCCAATAGAAACTGGAATTCTCCAGTTGCTAATTTCATAATGGAGTCACAAAG
ACTGGAATTAATCAGACTAATGGAGACCCAAGAGGAAGATGTGGTCCTACTAACTGCTGGAGAGCACAATAAAGCATGCTCTTTGTTAGG
AAAATTACGACTGGAATGTGCTGACCTTCTAGAAACAAGAGGAGTGGTGCTCCGTGACCCCACTCTGTTCTCTTTCCTTTGGGTGGTAGA
TTTCCCACTCTTCCTGCCCAAGGAGGAAAATCCCAGAGAGCTGGAATCGGCCCACCACCCATTTACTGCTCCCCACCCCAGTGACATACA
TCTCCTGTACACTGAGCCCAAAAAGGCCCGTAGCCAACACTATGACTTGGTTTTAAATGGCAATGAAATAGGAGGTGGTTCAATTCGAAT
TCACAATGCAGAGCTGCAGCGTTATATCCTGGCAACCTTACTAAAGGAGGATGTGAAAATGCTCTCCCATCTGCTCCAGGCTTTAGATTA
TGGGGCACCCCCTCATGGAGGAATTGCCTTAGGGTTAGACAGACTGATATGCCTTGTCACTGGATCTCCAAGCATCAGAGATGTCATAGC
CTTCCCAAAGTCCTTCCGGGGACATGACCTCATGAGCAATACCCCAGATTCTGTCCCTCCTGAGGAACTGAAGCCCTATCATATCCGAGT
CTCCAAGCCAACAGACTCCAAAGCAGAAAGAGCTCATTGAATCATGCATACCATGCAGAAAGTTGAGCTTTTAGGTTTTGTCCTCTTTGC
TTCCCCAAGGCTAAAGTCAGATCTAGAGTTCTGCCACAGGTCTAACAATCAAGTCTTTAGATGGAAGGAATCCAGGCAACATTCTTCACC
ACAACGAAGAAACAGATAAAAGATACCCAATTTTGACTTGATTTCATGCATCATTTGGATTTTTTTTGGTTAGGACTTTTTTTGAAGTTC
CTTTTTACTTAGGTGTGAAAGATGGTTCTTTGTTGAAATAATATAGTGGTTTAGTGTTTTCAAATCATGTTTCTCATACCCAGATAGTAG
ATTATTCACTTAGGACAGAGGTAATCAAATTATGTGTGAAATGTAGGAAAATGCTTGCCCCTGTAAACTAGTGAGTTGATGGAGCATTTG
CTTCATCATCCTCATCAAGAGAATCATATAAATTAAGCTTTATAATGACATTTCAACCATCAACATAATATAGTGAGGAGTAGCATAATA
TTTTTTAATAATGCAGAAAACATCACTGAAATGAGAGTCACAAATTTTTCTTCAGTGTTTCAGCCTGAGTAAGTTACATAAACCTCGCTT
AGCCTCCCTTCCTGCTAATGTGTAAAATACATACTTGCCCTGGCTACCTCACCGGGCTGTTATTGCTGGAATCAGAGGAGATAACATATA
TGGAAGATAAAGTGAATAAAAGTACTTTGAAAAACTATAAAGCATTCCACAAATATGAGATGATGGTATTATCCATCCATAAATAGGTAG

>42953_42953_1_KLHL20-DARS2_KLHL20_chr1_173703425_ENST00000209884_DARS2_chr1_173819464_ENST00000361951_length(amino acids)=447AA_BP=0
MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACS
PYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH
SCRELLRIADKFTQHNFQEEILPVFLNANRNWNSPVANFIMESQRLELIRLMETQEEDVVLLTAGEHNKACSLLGKLRLECADLLETRGV
VLRDPTLFSFLWVVDFPLFLPKEENPRELESAHHPFTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLK

--------------------------------------------------------------
>42953_42953_2_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000209884_DARS2_chr1_173825803_ENST00000239457_length(transcript)=1995nt_BP=892nt
CTGCCTGCGTTAGCGGCGGTGGAGGAGGAGGCAGAGAGGAGTGGAGGGCGGAGTAGACGGAGGAGGCTGCTGCAGAGAAGAAAGTGTCAG
AGCCGGTTCGGCTTTAGAGTGTGGTGAAGGGTACTTTTCATGGTGCATGGAAGGAAAGCCAATGCGCAGGTGTACCAACATTCGACCAGG
AGAGACTGGAATGGATGTAACAAGCCGCTGCACCCTTGGAGACCCCAACAAACTGCCAGAAGGGGTTCCCCAACCTGCCCGCATGCCCTA
TATCTCAGACAAGCACCCTCGACAAACCTTGGAAGTGATTAACCTTCTGAGAAAGCACCGGGAGCTATGTGATGTGGTGCTAGTTGTGGG
CGCCAAGAAGATATATGCCCATCGAGTCATTTTGTCAGCCTGTAGTCCCTACTTCCGAGCTATGTTTACAGGAGAATTGGCAGAGAGCCG
TCAGACAGAAGTAGTGATCCGAGACATTGACGAGAGGGCTATGGAATTACTGATTGACTTTGCGTATACCTCCCAGATAACAGTAGAAGA
GGGCAATGTTCAGACTCTTCTGCCAGCTGCTTGCCTCCTCCAGCTGGCAGAAATACAGGAAGCCTGCTGTGAATTCTTAAAGAGACAATT
AGATCCTTCTAACTGCCTGGGCATTCGGGCTTTTGCTGACACACATTCATGTCGTGAGTTGCTAAGGATAGCAGACAAGTTCACCCAACA
TAACTTTCAAGAGGTAATGGAGAGTGAAGAGTTCATGTTGCTTCCAGCCAATCAACTCATTGATATAATATCCAGTGATGAGCTAAACGT
TCGCAGTGAAGAACAAGTGTTCAATGCAGTGATGGCCTGGGTCAAATACAGTATTCAGGAAAGACGTCCTCAATTACCCCAGGAGGATGT
GAAAATGCTCTCCCATCTGCTCCAGGCTTTAGATTATGGGGCACCCCCTCATGGAGGAATTGCCTTAGGGTTAGACAGACTGATATGCCT
TGTCACTGGATCTCCAAGCATCAGAGATGTCATAGCCTTCCCAAAGTCCTTCCGGGGACATGACCTCATGAGCAATACCCCAGATTCTGT
CCCTCCTGAGGAACTGAAGCCCTATCATATCCGAGTCTCCAAGCCAACAGACTCCAAAGCAGAAAGAGCTCATTGAATCATGCATACCAT
GCAGAAAGTTGAGCTTTTAGGTTTTGTCCTCTTTGCTTCCCCAAGGCTAAAGTCAGATCTAGAGTTCTGCCACAGGTCTAACAATCAAGT
CTTTAGATGGAAGGAATCCAGGCAACATTCTTCACCACAACGAAGAAACAGATAAAAGATACCCAATTTTGACTTGATTTCATGCATCAT
TTGGATTTTTTTTGGTTAGGACTTTTTTTGAAGTTCCTTTTTACTTAGGTGTGAAAGATGGTTCTTTGTTGAAATAATATAGTGGTTTAG
TGTTTTCAAATCATGTTTCTCATACCCAGATAGTAGATTATTCACTTAGGACAGAGGTAATCAAATTATGTGTGAAATGTAGGAAAATGC
TTGCCCCTGTAAACTAGTGAGTTGATGGAGCATTTGCTTCATCATCCTCATCAAGAGAATCATATAAATTAAGCTTTATAATGACATTTC
AACCATCAACATAATATAGTGAGGAGTAGCATAATATTTTTTAATAATGCAGAAAACATCACTGAAATGAGAGTCACAAATTTTTCTTCA
GTGTTTCAGCCTGAGTAAGTTACATAAACCTCGCTTAGCCTCCCTTCCTGCTAATGTGTAAAATACATACTTGCCCTGGCTACCTCACCG
GGCTGTTATTGCTGGAATCAGAGGAGATAACATATATGGAAGATAAAGTGAATAAAAGTACTTTGAAAAACTATAAAGCATTCCACAAAT
ATGAGATGATGGTATTATCCATCCATAAATAGGTAGATATATCTCTATTTTATAGTTTCAGATTAAACAAAACTGATATCAATAGTAAAA

>42953_42953_2_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000209884_DARS2_chr1_173825803_ENST00000239457_length(amino acids)=339AA_BP=0
MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACS
PYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH
SCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQEDVKMLSHLLQALDYGAP

--------------------------------------------------------------
>42953_42953_3_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000209884_DARS2_chr1_173825803_ENST00000361951_length(transcript)=1997nt_BP=892nt
CTGCCTGCGTTAGCGGCGGTGGAGGAGGAGGCAGAGAGGAGTGGAGGGCGGAGTAGACGGAGGAGGCTGCTGCAGAGAAGAAAGTGTCAG
AGCCGGTTCGGCTTTAGAGTGTGGTGAAGGGTACTTTTCATGGTGCATGGAAGGAAAGCCAATGCGCAGGTGTACCAACATTCGACCAGG
AGAGACTGGAATGGATGTAACAAGCCGCTGCACCCTTGGAGACCCCAACAAACTGCCAGAAGGGGTTCCCCAACCTGCCCGCATGCCCTA
TATCTCAGACAAGCACCCTCGACAAACCTTGGAAGTGATTAACCTTCTGAGAAAGCACCGGGAGCTATGTGATGTGGTGCTAGTTGTGGG
CGCCAAGAAGATATATGCCCATCGAGTCATTTTGTCAGCCTGTAGTCCCTACTTCCGAGCTATGTTTACAGGAGAATTGGCAGAGAGCCG
TCAGACAGAAGTAGTGATCCGAGACATTGACGAGAGGGCTATGGAATTACTGATTGACTTTGCGTATACCTCCCAGATAACAGTAGAAGA
GGGCAATGTTCAGACTCTTCTGCCAGCTGCTTGCCTCCTCCAGCTGGCAGAAATACAGGAAGCCTGCTGTGAATTCTTAAAGAGACAATT
AGATCCTTCTAACTGCCTGGGCATTCGGGCTTTTGCTGACACACATTCATGTCGTGAGTTGCTAAGGATAGCAGACAAGTTCACCCAACA
TAACTTTCAAGAGGTAATGGAGAGTGAAGAGTTCATGTTGCTTCCAGCCAATCAACTCATTGATATAATATCCAGTGATGAGCTAAACGT
TCGCAGTGAAGAACAAGTGTTCAATGCAGTGATGGCCTGGGTCAAATACAGTATTCAGGAAAGACGTCCTCAATTACCCCAGGAGGATGT
GAAAATGCTCTCCCATCTGCTCCAGGCTTTAGATTATGGGGCACCCCCTCATGGAGGAATTGCCTTAGGGTTAGACAGACTGATATGCCT
TGTCACTGGATCTCCAAGCATCAGAGATGTCATAGCCTTCCCAAAGTCCTTCCGGGGACATGACCTCATGAGCAATACCCCAGATTCTGT
CCCTCCTGAGGAACTGAAGCCCTATCATATCCGAGTCTCCAAGCCAACAGACTCCAAAGCAGAAAGAGCTCATTGAATCATGCATACCAT
GCAGAAAGTTGAGCTTTTAGGTTTTGTCCTCTTTGCTTCCCCAAGGCTAAAGTCAGATCTAGAGTTCTGCCACAGGTCTAACAATCAAGT
CTTTAGATGGAAGGAATCCAGGCAACATTCTTCACCACAACGAAGAAACAGATAAAAGATACCCAATTTTGACTTGATTTCATGCATCAT
TTGGATTTTTTTTGGTTAGGACTTTTTTTGAAGTTCCTTTTTACTTAGGTGTGAAAGATGGTTCTTTGTTGAAATAATATAGTGGTTTAG
TGTTTTCAAATCATGTTTCTCATACCCAGATAGTAGATTATTCACTTAGGACAGAGGTAATCAAATTATGTGTGAAATGTAGGAAAATGC
TTGCCCCTGTAAACTAGTGAGTTGATGGAGCATTTGCTTCATCATCCTCATCAAGAGAATCATATAAATTAAGCTTTATAATGACATTTC
AACCATCAACATAATATAGTGAGGAGTAGCATAATATTTTTTAATAATGCAGAAAACATCACTGAAATGAGAGTCACAAATTTTTCTTCA
GTGTTTCAGCCTGAGTAAGTTACATAAACCTCGCTTAGCCTCCCTTCCTGCTAATGTGTAAAATACATACTTGCCCTGGCTACCTCACCG
GGCTGTTATTGCTGGAATCAGAGGAGATAACATATATGGAAGATAAAGTGAATAAAAGTACTTTGAAAAACTATAAAGCATTCCACAAAT
ATGAGATGATGGTATTATCCATCCATAAATAGGTAGATATATCTCTATTTTATAGTTTCAGATTAAACAAAACTGATATCAATAGTAAAA

>42953_42953_3_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000209884_DARS2_chr1_173825803_ENST00000361951_length(amino acids)=339AA_BP=0
MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACS
PYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH
SCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQEDVKMLSHLLQALDYGAP

--------------------------------------------------------------
>42953_42953_4_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000546011_DARS2_chr1_173825803_ENST00000239457_length(transcript)=1435nt_BP=332nt
CTACGAGCGGCATCCTGCCTGCGTTAGCGGCGGTGGAGGAGGAGGCAGAGAGGAGTGGAGGGCGGAGTAGACGGAGGAGGCTGCTGCAGA
GAAGAAAGTGTCAGAGCCGGTTCGGCTTTAGAGTGTGGTGAAGGGTACTTTTCATGGTGCATGGAAGGAAAGCCAATGCGCAGGTAATGG
AGAGTGAAGAGTTCATGTTGCTTCCAGCCAATCAACTCATTGATATAATATCCAGTGATGAGCTAAACGTTCGCAGTGAAGAACAAGTGT
TCAATGCAGTGATGGCCTGGGTCAAATACAGTATTCAGGAAAGACGTCCTCAATTACCCCAGGAGGATGTGAAAATGCTCTCCCATCTGC
TCCAGGCTTTAGATTATGGGGCACCCCCTCATGGAGGAATTGCCTTAGGGTTAGACAGACTGATATGCCTTGTCACTGGATCTCCAAGCA
TCAGAGATGTCATAGCCTTCCCAAAGTCCTTCCGGGGACATGACCTCATGAGCAATACCCCAGATTCTGTCCCTCCTGAGGAACTGAAGC
CCTATCATATCCGAGTCTCCAAGCCAACAGACTCCAAAGCAGAAAGAGCTCATTGAATCATGCATACCATGCAGAAAGTTGAGCTTTTAG
GTTTTGTCCTCTTTGCTTCCCCAAGGCTAAAGTCAGATCTAGAGTTCTGCCACAGGTCTAACAATCAAGTCTTTAGATGGAAGGAATCCA
GGCAACATTCTTCACCACAACGAAGAAACAGATAAAAGATACCCAATTTTGACTTGATTTCATGCATCATTTGGATTTTTTTTGGTTAGG
ACTTTTTTTGAAGTTCCTTTTTACTTAGGTGTGAAAGATGGTTCTTTGTTGAAATAATATAGTGGTTTAGTGTTTTCAAATCATGTTTCT
CATACCCAGATAGTAGATTATTCACTTAGGACAGAGGTAATCAAATTATGTGTGAAATGTAGGAAAATGCTTGCCCCTGTAAACTAGTGA
GTTGATGGAGCATTTGCTTCATCATCCTCATCAAGAGAATCATATAAATTAAGCTTTATAATGACATTTCAACCATCAACATAATATAGT
GAGGAGTAGCATAATATTTTTTAATAATGCAGAAAACATCACTGAAATGAGAGTCACAAATTTTTCTTCAGTGTTTCAGCCTGAGTAAGT
TACATAAACCTCGCTTAGCCTCCCTTCCTGCTAATGTGTAAAATACATACTTGCCCTGGCTACCTCACCGGGCTGTTATTGCTGGAATCA
GAGGAGATAACATATATGGAAGATAAAGTGAATAAAAGTACTTTGAAAAACTATAAAGCATTCCACAAATATGAGATGATGGTATTATCC

>42953_42953_4_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000546011_DARS2_chr1_173825803_ENST00000239457_length(amino acids)=150AA_BP=0
MVHGRKANAQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQEDVKMLSHLLQALDYGAPPHGGIALGL

--------------------------------------------------------------
>42953_42953_5_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000546011_DARS2_chr1_173825803_ENST00000361951_length(transcript)=1437nt_BP=332nt
CTACGAGCGGCATCCTGCCTGCGTTAGCGGCGGTGGAGGAGGAGGCAGAGAGGAGTGGAGGGCGGAGTAGACGGAGGAGGCTGCTGCAGA
GAAGAAAGTGTCAGAGCCGGTTCGGCTTTAGAGTGTGGTGAAGGGTACTTTTCATGGTGCATGGAAGGAAAGCCAATGCGCAGGTAATGG
AGAGTGAAGAGTTCATGTTGCTTCCAGCCAATCAACTCATTGATATAATATCCAGTGATGAGCTAAACGTTCGCAGTGAAGAACAAGTGT
TCAATGCAGTGATGGCCTGGGTCAAATACAGTATTCAGGAAAGACGTCCTCAATTACCCCAGGAGGATGTGAAAATGCTCTCCCATCTGC
TCCAGGCTTTAGATTATGGGGCACCCCCTCATGGAGGAATTGCCTTAGGGTTAGACAGACTGATATGCCTTGTCACTGGATCTCCAAGCA
TCAGAGATGTCATAGCCTTCCCAAAGTCCTTCCGGGGACATGACCTCATGAGCAATACCCCAGATTCTGTCCCTCCTGAGGAACTGAAGC
CCTATCATATCCGAGTCTCCAAGCCAACAGACTCCAAAGCAGAAAGAGCTCATTGAATCATGCATACCATGCAGAAAGTTGAGCTTTTAG
GTTTTGTCCTCTTTGCTTCCCCAAGGCTAAAGTCAGATCTAGAGTTCTGCCACAGGTCTAACAATCAAGTCTTTAGATGGAAGGAATCCA
GGCAACATTCTTCACCACAACGAAGAAACAGATAAAAGATACCCAATTTTGACTTGATTTCATGCATCATTTGGATTTTTTTTGGTTAGG
ACTTTTTTTGAAGTTCCTTTTTACTTAGGTGTGAAAGATGGTTCTTTGTTGAAATAATATAGTGGTTTAGTGTTTTCAAATCATGTTTCT
CATACCCAGATAGTAGATTATTCACTTAGGACAGAGGTAATCAAATTATGTGTGAAATGTAGGAAAATGCTTGCCCCTGTAAACTAGTGA
GTTGATGGAGCATTTGCTTCATCATCCTCATCAAGAGAATCATATAAATTAAGCTTTATAATGACATTTCAACCATCAACATAATATAGT
GAGGAGTAGCATAATATTTTTTAATAATGCAGAAAACATCACTGAAATGAGAGTCACAAATTTTTCTTCAGTGTTTCAGCCTGAGTAAGT
TACATAAACCTCGCTTAGCCTCCCTTCCTGCTAATGTGTAAAATACATACTTGCCCTGGCTACCTCACCGGGCTGTTATTGCTGGAATCA
GAGGAGATAACATATATGGAAGATAAAGTGAATAAAAGTACTTTGAAAAACTATAAAGCATTCCACAAATATGAGATGATGGTATTATCC

>42953_42953_5_KLHL20-DARS2_KLHL20_chr1_173721061_ENST00000546011_DARS2_chr1_173825803_ENST00000361951_length(amino acids)=150AA_BP=0
MVHGRKANAQVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQEDVKMLSHLLQALDYGAPPHGGIALGL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KLHL20-DARS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KLHL20-DARS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KLHL20-DARS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source