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	Fusion Gene Summary
	Fusion Gene ORF analysis
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	Fusion Gene Sequence
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Fusion gene:KLHL24-ATP11B (FusionGDB2 ID:42969)

Fusion Gene Summary for KLHL24-ATP11B

Fusion gene summary

Fusion gene information	Fusion gene name: KLHL24-ATP11B
	Fusion gene ID: 42969
		Hgene	Tgene
	Gene symbol	KLHL24	ATP11B
	Gene ID	54800	23200
	Gene name	kelch like family member 24	ATPase phospholipid transporting 11B (putative)
	Synonyms	DRE1\|EBSSH\|KRIP6	ATPIF\|ATPIR
	Cytomap	3q27.1	3q26.33
	Type of gene	protein-coding	protein-coding
	Description	kelch-like protein 24kainate receptor interacting protein for GluR6kelch-like 24	probable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B protein
	Modification date	20200313	20200313
	UniProtAcc	Q6TFL4	Q9Y2G3
	Ensembl transtripts involved in fusion gene	ENST00000242810, ENST00000454652, ENST00000476808, ENST00000461813,	ENST00000482794, ENST00000493826, ENST00000323116,
Fusion gene scores	* DoF score	11 X 11 X 5=605	12 X 11 X 4=528
	# samples	14	14
	** MAII score	log2(14/605*10)=-2.11150831521699 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/528*10)=-1.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KLHL24 [Title/Abstract] AND ATP11B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLHL24(183390272)-ATP11B(182631649), # samples:3
Anticipated loss of major functional domain due to fusion event.	KLHL24-ATP11B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. KLHL24-ATP11B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KLHL24	GO:0016567	protein ubiquitination	27798626

Fusion gene breakpoints across KLHL24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP11B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-G7-6793-01A	KLHL24	chr3	183390272	-	ATP11B	chr3	182631649	+
ChimerDB4	KIRP	TCGA-G7-6793-01A	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
ChimerDB4	KIRP	TCGA-G7-6793	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
ChimerDB4	KIRP	TCGA-G7-6793	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+

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Fusion Gene ORF analysis for KLHL24-ATP11B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000242810	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
5CDS-intron	ENST00000242810	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
5CDS-intron	ENST00000242810	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
5CDS-intron	ENST00000242810	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
5CDS-intron	ENST00000454652	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
5CDS-intron	ENST00000454652	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
5CDS-intron	ENST00000454652	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
5CDS-intron	ENST00000454652	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
5CDS-intron	ENST00000476808	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
5CDS-intron	ENST00000476808	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
5CDS-intron	ENST00000476808	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
5CDS-intron	ENST00000476808	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
Frame-shift	ENST00000476808	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
Frame-shift	ENST00000476808	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
In-frame	ENST00000242810	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
In-frame	ENST00000242810	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
In-frame	ENST00000454652	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
In-frame	ENST00000454652	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
intron-3CDS	ENST00000461813	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
intron-3CDS	ENST00000461813	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
intron-intron	ENST00000461813	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
intron-intron	ENST00000461813	ENST00000482794	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+
intron-intron	ENST00000461813	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+
intron-intron	ENST00000461813	ENST00000493826	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000242810

KLHL24

chr3

183390272

ENST00000323116

ATP11B

chr3

182631649

5699

1952

350

2167

605

ENST00000454652

KLHL24

chr3

183390272

ENST00000323116

ATP11B

chr3

182631649

5735

1988

386

2203

605

ENST00000242810

KLHL24

chr3

183390272

ENST00000323116

ATP11B

chr3

182631648

5699

1952

350

2167

605

ENST00000454652

KLHL24

chr3

183390272

ENST00000323116

ATP11B

chr3

182631648

5735

1988

386

2203

605

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000242810	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+	9.84E-05	0.99990165
ENST00000454652	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631649	+	0.000100139	0.99989986
ENST00000242810	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+	9.84E-05	0.99990165
ENST00000454652	ENST00000323116	KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+	0.000100139	0.99989986

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Fusion Genomic Features for KLHL24-ATP11B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+	4.52E-05	0.9999548
KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+	4.52E-05	0.9999548
KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+	4.52E-05	0.9999548
KLHL24	chr3	183390272	+	ATP11B	chr3	182631648	+	4.52E-05	0.9999548

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLHL24-ATP11B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183390272/chr3:182631649)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLHL24 Q6TFL4	ATP11B Q9Y2G3
FUNCTION: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). {ECO:0000250\|UniProtKB:Q56A24, ECO:0000269\|PubMed:27798626, ECO:0000269\|PubMed:27889062}.	FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269\|PubMed:30018401}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

168_270

534

601.0

Domain

Note=BACK

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

66_133

534

601.0

Domain

BTB

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

168_270

534

601.0

Domain

Note=BACK

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

66_133

534

601.0

Domain

BTB

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

168_270

534

601.0

Domain

Note=BACK

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

66_133

534

601.0

Domain

BTB

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

168_270

534

601.0

Domain

Note=BACK

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

66_133

534

601.0

Domain

BTB

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

314_363

534

601.0

Repeat

Note=Kelch 1

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

365_407

534

601.0

Repeat

Note=Kelch 2

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

408_454

534

601.0

Repeat

Note=Kelch 3

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

456_502

534

601.0

Repeat

Note=Kelch 4

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

314_363

534

601.0

Repeat

Note=Kelch 1

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

365_407

534

601.0

Repeat

Note=Kelch 2

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

408_454

534

601.0

Repeat

Note=Kelch 3

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

456_502

534

601.0

Repeat

Note=Kelch 4

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

314_363

534

601.0

Repeat

Note=Kelch 1

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

365_407

534

601.0

Repeat

Note=Kelch 2

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

408_454

534

601.0

Repeat

Note=Kelch 3

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

456_502

534

601.0

Repeat

Note=Kelch 4

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

314_363

534

601.0

Repeat

Note=Kelch 1

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

365_407

534

601.0

Repeat

Note=Kelch 2

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

408_454

534

601.0

Repeat

Note=Kelch 3

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

456_502

534

601.0

Repeat

Note=Kelch 4

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

1021_1025

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

1048_1065

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

105_289

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

1091_1177

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

1_55

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

312_341

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

360_876

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

78_82

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

899_910

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

931_960

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

983_997

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

1021_1025

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

1048_1065

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

105_289

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

1091_1177

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

1_55

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

312_341

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

360_876

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

78_82

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

899_910

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

931_960

196.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

983_997

196.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

1026_1047

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

1066_1090

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

290_311

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

342_359

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

56_77

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

83_104

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

877_898

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

911_930

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

961_982

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000493826

998_1020

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

1026_1047

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

1066_1090

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

290_311

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

342_359

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

56_77

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

83_104

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

877_898

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

911_930

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

961_982

196.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000493826

998_1020

196.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

168_270

538.0

Domain

Note=BACK

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

66_133

538.0

Domain

BTB

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

168_270

538.0

Domain

Note=BACK

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

66_133

538.0

Domain

BTB

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

504_544

534

601.0

Repeat

Note=Kelch 5

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000242810

546_592

534

601.0

Repeat

Note=Kelch 6

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

504_544

534

601.0

Repeat

Note=Kelch 5

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000454652

546_592

534

601.0

Repeat

Note=Kelch 6

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

314_363

538.0

Repeat

Note=Kelch 1

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

365_407

538.0

Repeat

Note=Kelch 2

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

408_454

538.0

Repeat

Note=Kelch 3

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

456_502

538.0

Repeat

Note=Kelch 4

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

504_544

538.0

Repeat

Note=Kelch 5

Hgene

KLHL24

chr3:183390272

chr3:182631648

ENST00000476808

546_592

538.0

Repeat

Note=Kelch 6

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

504_544

534

601.0

Repeat

Note=Kelch 5

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000242810

546_592

534

601.0

Repeat

Note=Kelch 6

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

504_544

534

601.0

Repeat

Note=Kelch 5

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000454652

546_592

534

601.0

Repeat

Note=Kelch 6

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

314_363

538.0

Repeat

Note=Kelch 1

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

365_407

538.0

Repeat

Note=Kelch 2

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

408_454

538.0

Repeat

Note=Kelch 3

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

456_502

538.0

Repeat

Note=Kelch 4

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

504_544

538.0

Repeat

Note=Kelch 5

Hgene

KLHL24

chr3:183390272

chr3:182631649

ENST00000476808

546_592

538.0

Repeat

Note=Kelch 6

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

1021_1025

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

1048_1065

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

105_289

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

1091_1177

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

1_55

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

312_341

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

360_876

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

78_82

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

899_910

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

931_960

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

983_997

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

1021_1025

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

1048_1065

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

105_289

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

1091_1177

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

1_55

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

312_341

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

360_876

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

78_82

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

899_910

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

931_960

1106

1178.0

Topological domain

Cytoplasmic

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

983_997

1106

1178.0

Topological domain

Extracellular

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

1026_1047

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

1066_1090

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

290_311

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

342_359

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

56_77

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

83_104

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

877_898

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

911_930

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

961_982

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631648

ENST00000323116

998_1020

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

1026_1047

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

1066_1090

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

290_311

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

342_359

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

56_77

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

83_104

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

877_898

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

911_930

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

961_982

1106

1178.0

Transmembrane

Helical

Tgene

ATP11B

chr3:183390272

chr3:182631649

ENST00000323116

998_1020

1106

1178.0

Transmembrane

Helical

Top

Fusion Gene Sequence for KLHL24-ATP11B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>42969_42969_1_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000242810_ATP11B_chr3_182631648_ENST00000323116_length(transcript)=5699nt_BP=1952nt
GGCCAGGGTTCGCTGACGCTCAGTGTTTTGGCCCGGACGGTCACATGTTTCCTTTGTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGA
GACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTTAGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAG
GTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGTGTGGAAATTAAAAGAACACACATATTTTGACTGGGGCTTTGA
TCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAACAATTATATAGTCAACTGATGTAACAATGGTACTAA
TATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTC
TGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGTGATAGCCGCT
TATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTA
TGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATG
TTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATG
CATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTCAAAACACTCT
TCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGATGAACTTATTG
ATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGA
GAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAAGTGGACCAAT
TGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCCCCAAGGACTA
GGCCACGCAGGTCCACTGGCTATTCTGAGGTGATAGTTGTCGTTGGAGGATGTGAGCGAGTTGGAGGATTTAATCTTCCATACACTGAGT
GCTACGATCCTGTAACAGGAGAATGGAAGTCTTTGGCTAAGCTTCCAGAATTTACCAAATCAGAGTATGCAGTCTGTGCTCTAAGGAATG
ACATTCTTGTTTCAGGTGGAAGAATCAACAGCCGTGATGTCTGGATTTATAACTCACAGTTAAATATTTGGATCAGAGTTGCCTCTCTCA
ATAAAGGCAGATGGCGTCACAAAATGGCTGTCCTCCTTGGTAAAGTATATGTTGTCGGTGGCTATGATGGGCAAAACAGACTTAGCAGCG
TAGAATGTTATGATTCCTTTTCAAATCGATGGACTGAAGTTGCTCCCCTTAAGGAAGCCGTGAGTTCTCCTGCAGTGACTAGCTGTGTAG
GCAAACTGTTTGTGATTGGTGGAGGACCTGATGATAATACTTGTTCTGATAAGGTTCAATCTTATGATCCAGAAACCAATTCTTGGCTAC
TTCGTGCAGCTATCCCAATTGCCAAAAGGTGTATAACAGCTGTATCCCTAAACAACCTGATCTATGTTGCCGGTGGACTGACCAAGGCAA
TATACTGTTACGATCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCAGCCGTCAGCTTACTGAAACAAATGCAGGTATCAAGT
GCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTGGAAGAATGCTGGAACGAGTTATAGGAAGATGTAGTC
CAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACAGGAGCATCTTGACTCTCTCCACAATGGACTCATCTA
CTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAAATTCAGTGTGATCACCCTGTTAATGGCCACACTAGC
TCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATAATGGCAAACAAACAGAAAGCATTAGTACAAGCCCCT
CCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACATTTTTCATCTCTTTGTCTGGTTTGTCCCTTGTGCTT
ATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATATAAATGTAGAAAAAAGAGAGAAATCTTAGTAAAGAGT
ATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAAATTATGCTGAAAGTTTGCCTTGAGAACTCTATTTTT
TTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAGGAATTTTGGTCCCTCAGTGACCTGTGTTGTTAATTC
ATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTATTTACTGCAGTATGGGGAGTAAATTTATACCAATTC
CTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTATATCATATATACAAATCAGGAATCAGGTCCGTTCAC
CGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTATAGTGGGTAAATTAGATACTATTAGCATATTATTAA
TTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTTAAATTTGCTTTTTTTCTCTTTACCTGAAGGCTCTGT
GTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTGGACAGTATTTAAATATTGCAAATATGTTTAATTATA
CAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCTGCAGCCGACTTAGACATGCTCTTCCCTTTCTATAAG
CTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCATCTAACTTATAGCAAACTACCACAATACAGTGAGTT
CTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAATGCTCAACTTGTATCAGGTAATGTTAGCAATAAATT
AAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACTTCAAAACCTAACTTCCATCCTGAATTTATCAAGTAG
TTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATTTAGAAGTGATTATTAGCTTGAGAACTATTACCCAGC
TCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTACCAAGTTTTCCCTTGAAAATGTAATTCCTTTATGGA
GATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTAGAATTGGACTGGCAGGGGAAAGAATGGTAGAGACAG
AAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTAACATTTGTCTGTTCCAGTGATGTAAGGATATTAAGT
TATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTCATAGCTGGATTTAGGAAGATCTGTTATTCTGGAAGT
ACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAGAAGAGGAAATAATGAAGATATACTCAGTAGAGTACT
AGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATAACAAAATGACACCCAGTAGGCCTGCATTACATTTAC
ATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGACTCCAAAGTCATAAAATAGCCTATGACCAACTGCAGC
AAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATTTTCTGTACTCACCATTTGAAGTTAGTTAAGGAGAAC
TTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTGTTACTCCAAATCCACTCCGTTTTTAAAGCAAAATTA
TCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAGTCTGCAAGCTTTCAGTAGTTTTCTAGTGCTATATTC
ATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTTGCATATTTCTTTAAAATTCTTTCTTTGGAAAGTATG
ATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATACGTTATTGCTAATCAGTGGTCTCAAATCGATTTGCC
TCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGTCAGTTTCCAAAATTGCCCCTCAGCTGCTTTAAGTGA
CTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAAGTATGGGCCAGGGAGAACTACAGCTACGAAGACCTG
CTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTCTTTCTTGGGTCTAAAGCTCATAATACACAAAGGCTT
CCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCAAATCAACCCTAGGAAATACTTGCATTCTGCCCTACG
GTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTTATCTGATCGCTTGAGACTCCTAATAGGCAGGAGTCA
AGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTCTGAAAAATCTCGTGAAGGCTGTAGGAAAAGGGAGAA
TCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCAGGTATTAATAAAAATAACACACCAAAGAGTTACGTA
AAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTGAAATGAGTTATCTATTTTCATAAAAGTAAAACACTA
TTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGATCATAACTCATGATATGTTTGTAATCATGGTAATTT
AGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAAATTTTGGACCTGAGACACTGTGGCTGTCTAATGTAA
TCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTACTCATAATTTTTTAAAGTTTATGAAGTTATATTTAT

>42969_42969_1_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000242810_ATP11B_chr3_182631648_ENST00000323116_length(amino acids)=605AA_BP=533
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQLTETNA

--------------------------------------------------------------
>42969_42969_2_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000242810_ATP11B_chr3_182631649_ENST00000323116_length(transcript)=5699nt_BP=1952nt
GGCCAGGGTTCGCTGACGCTCAGTGTTTTGGCCCGGACGGTCACATGTTTCCTTTGTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGA
GACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTTAGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAG
GTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGTGTGGAAATTAAAAGAACACACATATTTTGACTGGGGCTTTGA
TCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAACAATTATATAGTCAACTGATGTAACAATGGTACTAA
TATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTC
TGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGTGATAGCCGCT
TATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTA
TGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATG
TTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATG
CATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTCAAAACACTCT
TCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGATGAACTTATTG
ATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGA
GAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAAGTGGACCAAT
TGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCCCCAAGGACTA
GGCCACGCAGGTCCACTGGCTATTCTGAGGTGATAGTTGTCGTTGGAGGATGTGAGCGAGTTGGAGGATTTAATCTTCCATACACTGAGT
GCTACGATCCTGTAACAGGAGAATGGAAGTCTTTGGCTAAGCTTCCAGAATTTACCAAATCAGAGTATGCAGTCTGTGCTCTAAGGAATG
ACATTCTTGTTTCAGGTGGAAGAATCAACAGCCGTGATGTCTGGATTTATAACTCACAGTTAAATATTTGGATCAGAGTTGCCTCTCTCA
ATAAAGGCAGATGGCGTCACAAAATGGCTGTCCTCCTTGGTAAAGTATATGTTGTCGGTGGCTATGATGGGCAAAACAGACTTAGCAGCG
TAGAATGTTATGATTCCTTTTCAAATCGATGGACTGAAGTTGCTCCCCTTAAGGAAGCCGTGAGTTCTCCTGCAGTGACTAGCTGTGTAG
GCAAACTGTTTGTGATTGGTGGAGGACCTGATGATAATACTTGTTCTGATAAGGTTCAATCTTATGATCCAGAAACCAATTCTTGGCTAC
TTCGTGCAGCTATCCCAATTGCCAAAAGGTGTATAACAGCTGTATCCCTAAACAACCTGATCTATGTTGCCGGTGGACTGACCAAGGCAA
TATACTGTTACGATCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCAGCCGTCAGCTTACTGAAACAAATGCAGGTATCAAGT
GCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTGGAAGAATGCTGGAACGAGTTATAGGAAGATGTAGTC
CAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACAGGAGCATCTTGACTCTCTCCACAATGGACTCATCTA
CTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAAATTCAGTGTGATCACCCTGTTAATGGCCACACTAGC
TCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATAATGGCAAACAAACAGAAAGCATTAGTACAAGCCCCT
CCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACATTTTTCATCTCTTTGTCTGGTTTGTCCCTTGTGCTT
ATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATATAAATGTAGAAAAAAGAGAGAAATCTTAGTAAAGAGT
ATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAAATTATGCTGAAAGTTTGCCTTGAGAACTCTATTTTT
TTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAGGAATTTTGGTCCCTCAGTGACCTGTGTTGTTAATTC
ATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTATTTACTGCAGTATGGGGAGTAAATTTATACCAATTC
CTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTATATCATATATACAAATCAGGAATCAGGTCCGTTCAC
CGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTATAGTGGGTAAATTAGATACTATTAGCATATTATTAA
TTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTTAAATTTGCTTTTTTTCTCTTTACCTGAAGGCTCTGT
GTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTGGACAGTATTTAAATATTGCAAATATGTTTAATTATA
CAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCTGCAGCCGACTTAGACATGCTCTTCCCTTTCTATAAG
CTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCATCTAACTTATAGCAAACTACCACAATACAGTGAGTT
CTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAATGCTCAACTTGTATCAGGTAATGTTAGCAATAAATT
AAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACTTCAAAACCTAACTTCCATCCTGAATTTATCAAGTAG
TTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATTTAGAAGTGATTATTAGCTTGAGAACTATTACCCAGC
TCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTACCAAGTTTTCCCTTGAAAATGTAATTCCTTTATGGA
GATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTAGAATTGGACTGGCAGGGGAAAGAATGGTAGAGACAG
AAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTAACATTTGTCTGTTCCAGTGATGTAAGGATATTAAGT
TATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTCATAGCTGGATTTAGGAAGATCTGTTATTCTGGAAGT
ACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAGAAGAGGAAATAATGAAGATATACTCAGTAGAGTACT
AGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATAACAAAATGACACCCAGTAGGCCTGCATTACATTTAC
ATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGACTCCAAAGTCATAAAATAGCCTATGACCAACTGCAGC
AAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATTTTCTGTACTCACCATTTGAAGTTAGTTAAGGAGAAC
TTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTGTTACTCCAAATCCACTCCGTTTTTAAAGCAAAATTA
TCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAGTCTGCAAGCTTTCAGTAGTTTTCTAGTGCTATATTC
ATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTTGCATATTTCTTTAAAATTCTTTCTTTGGAAAGTATG
ATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATACGTTATTGCTAATCAGTGGTCTCAAATCGATTTGCC
TCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGTCAGTTTCCAAAATTGCCCCTCAGCTGCTTTAAGTGA
CTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAAGTATGGGCCAGGGAGAACTACAGCTACGAAGACCTG
CTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTCTTTCTTGGGTCTAAAGCTCATAATACACAAAGGCTT
CCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCAAATCAACCCTAGGAAATACTTGCATTCTGCCCTACG
GTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTTATCTGATCGCTTGAGACTCCTAATAGGCAGGAGTCA
AGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTCTGAAAAATCTCGTGAAGGCTGTAGGAAAAGGGAGAA
TCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCAGGTATTAATAAAAATAACACACCAAAGAGTTACGTA
AAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTGAAATGAGTTATCTATTTTCATAAAAGTAAAACACTA
TTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGATCATAACTCATGATATGTTTGTAATCATGGTAATTT
AGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAAATTTTGGACCTGAGACACTGTGGCTGTCTAATGTAA
TCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTACTCATAATTTTTTAAAGTTTATGAAGTTATATTTAT

>42969_42969_2_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000242810_ATP11B_chr3_182631649_ENST00000323116_length(amino acids)=605AA_BP=533
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQLTETNA

--------------------------------------------------------------
>42969_42969_3_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000454652_ATP11B_chr3_182631648_ENST00000323116_length(transcript)=5735nt_BP=1988nt
GTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGAGACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTT
AGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAGGTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGAAGCCCGG
GGGAGTGCGACCGCCTCAAATCCAGCCTTCTTGTTTGGTGGGACGACCGTCGGTTCTGTCCGGGAGGAATGACGGGGTCAAGGTGTGGAA
ATTAAAAGAACACACATATTTTGACTGGGGCTTTGATCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAA
CAATTATATAGTCAACTGATGTAACAATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAA
CTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACA
TACTCCAGATATTTAATGAATTTCGTGATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAG
CTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTA
TTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGA
CATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCC
AGCGCTTTGCTGATACCCATTCACTCAAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACG
AAGAATTTCTTGAGCTTGACAAAGATGAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAG
CCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATC
CCAACTACTTTGTTCAAACAGTTGAAGTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACC
ACATACTTGGGAATGAAATGATGTCCCCAAGGACTAGGCCACGCAGGTCCACTGGCTATTCTGAGGTGATAGTTGTCGTTGGAGGATGTG
AGCGAGTTGGAGGATTTAATCTTCCATACACTGAGTGCTACGATCCTGTAACAGGAGAATGGAAGTCTTTGGCTAAGCTTCCAGAATTTA
CCAAATCAGAGTATGCAGTCTGTGCTCTAAGGAATGACATTCTTGTTTCAGGTGGAAGAATCAACAGCCGTGATGTCTGGATTTATAACT
CACAGTTAAATATTTGGATCAGAGTTGCCTCTCTCAATAAAGGCAGATGGCGTCACAAAATGGCTGTCCTCCTTGGTAAAGTATATGTTG
TCGGTGGCTATGATGGGCAAAACAGACTTAGCAGCGTAGAATGTTATGATTCCTTTTCAAATCGATGGACTGAAGTTGCTCCCCTTAAGG
AAGCCGTGAGTTCTCCTGCAGTGACTAGCTGTGTAGGCAAACTGTTTGTGATTGGTGGAGGACCTGATGATAATACTTGTTCTGATAAGG
TTCAATCTTATGATCCAGAAACCAATTCTTGGCTACTTCGTGCAGCTATCCCAATTGCCAAAAGGTGTATAACAGCTGTATCCCTAAACA
ACCTGATCTATGTTGCCGGTGGACTGACCAAGGCAATATACTGTTACGATCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCA
GCCGTCAGCTTACTGAAACAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTG
GAAGAATGCTGGAACGAGTTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACA
GGAGCATCTTGACTCTCTCCACAATGGACTCATCTACTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAA
ATTCAGTGTGATCACCCTGTTAATGGCCACACTAGCTCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATA
ATGGCAAACAAACAGAAAGCATTAGTACAAGCCCCTCCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACA
TTTTTCATCTCTTTGTCTGGTTTGTCCCTTGTGCTTATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATAT
AAATGTAGAAAAAAGAGAGAAATCTTAGTAAAGAGTATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAA
ATTATGCTGAAAGTTTGCCTTGAGAACTCTATTTTTTTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAG
GAATTTTGGTCCCTCAGTGACCTGTGTTGTTAATTCATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTA
TTTACTGCAGTATGGGGAGTAAATTTATACCAATTCCTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTA
TATCATATATACAAATCAGGAATCAGGTCCGTTCACCGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTA
TAGTGGGTAAATTAGATACTATTAGCATATTATTAATTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTT
AAATTTGCTTTTTTTCTCTTTACCTGAAGGCTCTGTGTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTG
GACAGTATTTAAATATTGCAAATATGTTTAATTATACAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCT
GCAGCCGACTTAGACATGCTCTTCCCTTTCTATAAGCTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCA
TCTAACTTATAGCAAACTACCACAATACAGTGAGTTCTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAA
TGCTCAACTTGTATCAGGTAATGTTAGCAATAAATTAAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACT
TCAAAACCTAACTTCCATCCTGAATTTATCAAGTAGTTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATT
TAGAAGTGATTATTAGCTTGAGAACTATTACCCAGCTCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTA
CCAAGTTTTCCCTTGAAAATGTAATTCCTTTATGGAGATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTA
GAATTGGACTGGCAGGGGAAAGAATGGTAGAGACAGAAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTA
ACATTTGTCTGTTCCAGTGATGTAAGGATATTAAGTTATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTC
ATAGCTGGATTTAGGAAGATCTGTTATTCTGGAAGTACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAG
AAGAGGAAATAATGAAGATATACTCAGTAGAGTACTAGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATA
ACAAAATGACACCCAGTAGGCCTGCATTACATTTACATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGAC
TCCAAAGTCATAAAATAGCCTATGACCAACTGCAGCAAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATT
TTCTGTACTCACCATTTGAAGTTAGTTAAGGAGAACTTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTG
TTACTCCAAATCCACTCCGTTTTTAAAGCAAAATTATCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAG
TCTGCAAGCTTTCAGTAGTTTTCTAGTGCTATATTCATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTT
GCATATTTCTTTAAAATTCTTTCTTTGGAAAGTATGATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATA
CGTTATTGCTAATCAGTGGTCTCAAATCGATTTGCCTCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGT
CAGTTTCCAAAATTGCCCCTCAGCTGCTTTAAGTGACTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAA
GTATGGGCCAGGGAGAACTACAGCTACGAAGACCTGCTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTC
TTTCTTGGGTCTAAAGCTCATAATACACAAAGGCTTCCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCA
AATCAACCCTAGGAAATACTTGCATTCTGCCCTACGGTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTT
ATCTGATCGCTTGAGACTCCTAATAGGCAGGAGTCAAGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTC
TGAAAAATCTCGTGAAGGCTGTAGGAAAAGGGAGAATCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCA
GGTATTAATAAAAATAACACACCAAAGAGTTACGTAAAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTG
AAATGAGTTATCTATTTTCATAAAAGTAAAACACTATTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGA
TCATAACTCATGATATGTTTGTAATCATGGTAATTTAGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAA
ATTTTGGACCTGAGACACTGTGGCTGTCTAATGTAATCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTA

>42969_42969_3_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000454652_ATP11B_chr3_182631648_ENST00000323116_length(amino acids)=605AA_BP=533
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQLTETNA

--------------------------------------------------------------
>42969_42969_4_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000454652_ATP11B_chr3_182631649_ENST00000323116_length(transcript)=5735nt_BP=1988nt
GTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGAGACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTT
AGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAGGTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGAAGCCCGG
GGGAGTGCGACCGCCTCAAATCCAGCCTTCTTGTTTGGTGGGACGACCGTCGGTTCTGTCCGGGAGGAATGACGGGGTCAAGGTGTGGAA
ATTAAAAGAACACACATATTTTGACTGGGGCTTTGATCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAA
CAATTATATAGTCAACTGATGTAACAATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAA
CTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACA
TACTCCAGATATTTAATGAATTTCGTGATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAG
CTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTA
TTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGA
CATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCC
AGCGCTTTGCTGATACCCATTCACTCAAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACG
AAGAATTTCTTGAGCTTGACAAAGATGAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAG
CCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATC
CCAACTACTTTGTTCAAACAGTTGAAGTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACC
ACATACTTGGGAATGAAATGATGTCCCCAAGGACTAGGCCACGCAGGTCCACTGGCTATTCTGAGGTGATAGTTGTCGTTGGAGGATGTG
AGCGAGTTGGAGGATTTAATCTTCCATACACTGAGTGCTACGATCCTGTAACAGGAGAATGGAAGTCTTTGGCTAAGCTTCCAGAATTTA
CCAAATCAGAGTATGCAGTCTGTGCTCTAAGGAATGACATTCTTGTTTCAGGTGGAAGAATCAACAGCCGTGATGTCTGGATTTATAACT
CACAGTTAAATATTTGGATCAGAGTTGCCTCTCTCAATAAAGGCAGATGGCGTCACAAAATGGCTGTCCTCCTTGGTAAAGTATATGTTG
TCGGTGGCTATGATGGGCAAAACAGACTTAGCAGCGTAGAATGTTATGATTCCTTTTCAAATCGATGGACTGAAGTTGCTCCCCTTAAGG
AAGCCGTGAGTTCTCCTGCAGTGACTAGCTGTGTAGGCAAACTGTTTGTGATTGGTGGAGGACCTGATGATAATACTTGTTCTGATAAGG
TTCAATCTTATGATCCAGAAACCAATTCTTGGCTACTTCGTGCAGCTATCCCAATTGCCAAAAGGTGTATAACAGCTGTATCCCTAAACA
ACCTGATCTATGTTGCCGGTGGACTGACCAAGGCAATATACTGTTACGATCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCA
GCCGTCAGCTTACTGAAACAAATGCAGGTATCAAGTGCTTGGACTCCATGTGCTGTTTCCCGGAAGGAGAAGCAGCGTGTGCATCTGTTG
GAAGAATGCTGGAACGAGTTATAGGAAGATGTAGTCCAACCCACATCAGCAGATCATGGAGTGCATCGGATCCTTTCTATACCAACGACA
GGAGCATCTTGACTCTCTCCACAATGGACTCATCTACTTGTTAAAGGGGCAGTAGTACTTTGTGGGAGCCAGTTCACCTCCTTTCCTAAA
ATTCAGTGTGATCACCCTGTTAATGGCCACACTAGCTCTGAAATTAATTTCCAAAATCTTTGTAGTAGTTCATACCCACTCAGAGTTATA
ATGGCAAACAAACAGAAAGCATTAGTACAAGCCCCTCCCAACACCCTTAATTTGAATCTGAACATGTTAAAATTTGAGAATAAAGAGACA
TTTTTCATCTCTTTGTCTGGTTTGTCCCTTGTGCTTATGGGACTCCTAATGGCATTTCAGTCTGTTGCTGAGGCCATTATATTTTAATAT
AAATGTAGAAAAAAGAGAGAAATCTTAGTAAAGAGTATTTTTTAGTATTAGCTTGATTATTGACTCTTCTATTTAAATCTGCTTCTGTAA
ATTATGCTGAAAGTTTGCCTTGAGAACTCTATTTTTTTATTAGAGTTATATTTAAAGCTTTTCATGGGAAAAGTTAATGTGAATACTGAG
GAATTTTGGTCCCTCAGTGACCTGTGTTGTTAATTCATTAATGCATTCTGAGTTCACAGAGCAAATTAGGAGAATCATTTCCAACCATTA
TTTACTGCAGTATGGGGAGTAAATTTATACCAATTCCTCTAACTGTACTGTAACACAGCCTGTAAAGTTAGCCATATAAATGCAAGGGTA
TATCATATATACAAATCAGGAATCAGGTCCGTTCACCGAACTTCAAATTGATGTTTACTAATATTTTTGTGACAGAGTATAAAGACCCTA
TAGTGGGTAAATTAGATACTATTAGCATATTATTAATTTAATGTCTTTATCATTGGATCTTTTGCATGCTTTAATCTGGTTAACATATTT
AAATTTGCTTTTTTTCTCTTTACCTGAAGGCTCTGTGTATAGTATTTCATGACATCGTTGTACAGTTTAACTATATCAATAAAAAGTTTG
GACAGTATTTAAATATTGCAAATATGTTTAATTATACAAATCAGAATAGTATGGGTAATTAAATGAATACAAAAAGAAGAGCCTCTTTCT
GCAGCCGACTTAGACATGCTCTTCCCTTTCTATAAGCTAGATTTTAGAATAAAGGGTTTCAGTTAATAATCTTATTTTCAGGTTATGTCA
TCTAACTTATAGCAAACTACCACAATACAGTGAGTTCTGCCAGTGTCCCAGTACAAGGCATATTTCAGGTGTGGCTGTGGAATGTAAAAA
TGCTCAACTTGTATCAGGTAATGTTAGCAATAAATTAAATGCTAAGAATGATTAATCGGGTACATGTTACTGTAATTAACTCATTGCACT
TCAAAACCTAACTTCCATCCTGAATTTATCAAGTAGTTCAGTATTGTCATTTGTTTTTGTTTTATTGAAAAGTAATGTTGTCTTAAGATT
TAGAAGTGATTATTAGCTTGAGAACTATTACCCAGCTCTAAGCAAATAATGATTGTATACATATTAAGATAATGGTTAAATGCGGTTTTA
CCAAGTTTTCCCTTGAAAATGTAATTCCTTTATGGAGATTTATTGTGCAGCCCTAAGCTTCCTTCCCATTTCATGAATATAAGGCTTCTA
GAATTGGACTGGCAGGGGAAAGAATGGTAGAGACAGAAATTAAGACTTTATCCTTGTTTGCTTGTAAACTATTATTTTCTTGCTAATGTA
ACATTTGTCTGTTCCAGTGATGTAAGGATATTAAGTTATTAAGCTAAATATTAATTTTCAAAAATAGTCCTTCTTTAACTTAGATATTTC
ATAGCTGGATTTAGGAAGATCTGTTATTCTGGAAGTACTAAAAAGAATAATACAACGTACAATGTCTGCATTCACTAATTCATGTTCCAG
AAGAGGAAATAATGAAGATATACTCAGTAGAGTACTAGGTGGGAGGATATGGAAATTTGCTCATAAAATCTCTTATAAAACGTGCATATA
ACAAAATGACACCCAGTAGGCCTGCATTACATTTACATGACCGTGTTTATTTGCCATCAAATAAACTGAGTACTGACACCAGACAAAGAC
TCCAAAGTCATAAAATAGCCTATGACCAACTGCAGCAAGACAGGAGGTCAGCTCGCCTATAATGGTGCTTAAAGTGTGATTGATGTAATT
TTCTGTACTCACCATTTGAAGTTAGTTAAGGAGAACTTTATTTTTTTAAAAAAAGTAAATGGCAACCACTAGTGTGCTCATCCTGAACTG
TTACTCCAAATCCACTCCGTTTTTAAAGCAAAATTATCTTGTGATTTTAAGAAAAGAGTTTTCTATTTATTTAAGAAAGTAACAATGCAG
TCTGCAAGCTTTCAGTAGTTTTCTAGTGCTATATTCATCCTGTAAAACTCTTACTACGTAACCAGTAATCACAAGGAAAGTGTCCCCTTT
GCATATTTCTTTAAAATTCTTTCTTTGGAAAGTATGATGTTGATAATTAACTTACCCTTATCTGCCAAAACCAGAGCAAAATGCTAAATA
CGTTATTGCTAATCAGTGGTCTCAAATCGATTTGCCTCCCTTTGCCTCGTCTGAGGGCTGTAAGCCTGAAGATAGTGGCAAGCACCAAGT
CAGTTTCCAAAATTGCCCCTCAGCTGCTTTAAGTGACTCAGCACCCTGCCTCAGCTTCAGCAGGCGTAGGCTCACCCTGGGCGGAGCAAA
GTATGGGCCAGGGAGAACTACAGCTACGAAGACCTGCTGTCGAGTTGAGAAAAGGGGAGAATTTATGGTCTGAATTTTCTAACTGTCCTC
TTTCTTGGGTCTAAAGCTCATAATACACAAAGGCTTCCAGACCTGAGCCACACCCAGGCCCTATCCTGAACAGGAGACTAAACAGAGGCA
AATCAACCCTAGGAAATACTTGCATTCTGCCCTACGGTTAGTACCAGGACTGAGGTCATTTCTACTGGAAAAGATTGTGAGATTGAACTT
ATCTGATCGCTTGAGACTCCTAATAGGCAGGAGTCAAGGCCACTAGAAAATTGACAGTTAAGAGCCAAAAGTTTTTAAAATATGCTACTC
TGAAAAATCTCGTGAAGGCTGTAGGAAAAGGGAGAATCTTCCATGTTGGTGTTTTTCCTGTAAAGATCAGTTTGGGGTATGATATAAGCA
GGTATTAATAAAAATAACACACCAAAGAGTTACGTAAAACATGTTTTATTAATTTTGGTCCCCACGTACAGACATTTTATTTCTATTTTG
AAATGAGTTATCTATTTTCATAAAAGTAAAACACTATTAAAGTGCTGTTTTATGTGAAATAACTTGAATGTTGTTCCTATAAAAAATAGA
TCATAACTCATGATATGTTTGTAATCATGGTAATTTAGATTTTTATGAGGAATGAGTATCTGGAAATATTGTAGCAATACTTGGTTTAAA
ATTTTGGACCTGAGACACTGTGGCTGTCTAATGTAATCCTTTAAAAATTCTCTGCATTGTCAGTAAATGTAGTATATTATTGTACAGCTA

>42969_42969_4_KLHL24-ATP11B_KLHL24_chr3_183390272_ENST00000454652_ATP11B_chr3_182631649_ENST00000323116_length(amino acids)=605AA_BP=533
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT
SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQLTETNA

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Fusion Gene PPI Analysis for KLHL24-ATP11B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KLHL24-ATP11B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KLHL24-ATP11B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source