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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLHL24-CEP89 (FusionGDB2 ID:42971)

Fusion Gene Summary for KLHL24-CEP89

check button Fusion gene summary
Fusion gene informationFusion gene name: KLHL24-CEP89
Fusion gene ID: 42971
HgeneTgene
Gene symbol

KLHL24

CEP89

Gene ID

54800

84902

Gene namekelch like family member 24centrosomal protein 89
SynonymsDRE1|EBSSH|KRIP6CCDC123|CEP123
Cytomap

3q27.1

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionkelch-like protein 24kainate receptor interacting protein for GluR6kelch-like 24centrosomal protein of 89 kDacentrosomal protein 123centrosomal protein 89kDacoiled-coil domain containing 123coiled-coil domain-containing protein 123, mitochondrial
Modification date2020031320200313
UniProtAcc

Q6TFL4

Q96ST8

Ensembl transtripts involved in fusion geneENST00000242810, ENST00000454652, 
ENST00000476808, ENST00000461813, 
ENST00000590597, ENST00000591863, 
ENST00000305768, 
Fusion gene scores* DoF score11 X 11 X 5=60511 X 11 X 7=847
# samples 1415
** MAII scorelog2(14/605*10)=-2.11150831521699
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/847*10)=-2.49739946883632
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLHL24 [Title/Abstract] AND CEP89 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLHL24(183369064)-CEP89(33392318), # samples:2
KLHL24(183381430)-CEP89(33392318), # samples:2
Anticipated loss of major functional domain due to fusion event.KLHL24-CEP89 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLHL24

GO:0016567

protein ubiquitination

27798626


check buttonFusion gene breakpoints across KLHL24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP89 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-1071-01AKLHL24chr3

183369064

+CEP89chr19

33392318

-
ChimerDB4LUSCTCGA-21-1071-01AKLHL24chr3

183381430

-CEP89chr19

33392318

-
ChimerDB4LUSCTCGA-21-1071KLHL24chr3

183369064

+CEP89chr19

33392318

-
ChimerDB4LUSCTCGA-21-1071KLHL24chr3

183381430

+CEP89chr19

33392318

-


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Fusion Gene ORF analysis for KLHL24-CEP89

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000242810ENST00000590597KLHL24chr3

183369064

+CEP89chr19

33392318

-
5CDS-intronENST00000242810ENST00000590597KLHL24chr3

183381430

+CEP89chr19

33392318

-
5CDS-intronENST00000242810ENST00000591863KLHL24chr3

183369064

+CEP89chr19

33392318

-
5CDS-intronENST00000242810ENST00000591863KLHL24chr3

183381430

+CEP89chr19

33392318

-
5CDS-intronENST00000454652ENST00000590597KLHL24chr3

183369064

+CEP89chr19

33392318

-
5CDS-intronENST00000454652ENST00000590597KLHL24chr3

183381430

+CEP89chr19

33392318

-
5CDS-intronENST00000454652ENST00000591863KLHL24chr3

183369064

+CEP89chr19

33392318

-
5CDS-intronENST00000454652ENST00000591863KLHL24chr3

183381430

+CEP89chr19

33392318

-
5CDS-intronENST00000476808ENST00000590597KLHL24chr3

183369064

+CEP89chr19

33392318

-
5CDS-intronENST00000476808ENST00000590597KLHL24chr3

183381430

+CEP89chr19

33392318

-
5CDS-intronENST00000476808ENST00000591863KLHL24chr3

183369064

+CEP89chr19

33392318

-
5CDS-intronENST00000476808ENST00000591863KLHL24chr3

183381430

+CEP89chr19

33392318

-
Frame-shiftENST00000242810ENST00000305768KLHL24chr3

183381430

+CEP89chr19

33392318

-
Frame-shiftENST00000454652ENST00000305768KLHL24chr3

183381430

+CEP89chr19

33392318

-
Frame-shiftENST00000476808ENST00000305768KLHL24chr3

183381430

+CEP89chr19

33392318

-
In-frameENST00000242810ENST00000305768KLHL24chr3

183369064

+CEP89chr19

33392318

-
In-frameENST00000454652ENST00000305768KLHL24chr3

183369064

+CEP89chr19

33392318

-
In-frameENST00000476808ENST00000305768KLHL24chr3

183369064

+CEP89chr19

33392318

-
intron-3CDSENST00000461813ENST00000305768KLHL24chr3

183369064

+CEP89chr19

33392318

-
intron-3CDSENST00000461813ENST00000305768KLHL24chr3

183381430

+CEP89chr19

33392318

-
intron-intronENST00000461813ENST00000590597KLHL24chr3

183369064

+CEP89chr19

33392318

-
intron-intronENST00000461813ENST00000590597KLHL24chr3

183381430

+CEP89chr19

33392318

-
intron-intronENST00000461813ENST00000591863KLHL24chr3

183369064

+CEP89chr19

33392318

-
intron-intronENST00000461813ENST00000591863KLHL24chr3

183381430

+CEP89chr19

33392318

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000242810KLHL24chr3183369064+ENST00000305768CEP89chr1933392318-222312703502056568
ENST00000454652KLHL24chr3183369064+ENST00000305768CEP89chr1933392318-225913063862092568
ENST00000476808KLHL24chr3183369064+ENST00000305768CEP89chr1933392318-187392001706568

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000242810ENST00000305768KLHL24chr3183369064+CEP89chr1933392318-0.0011553280.9988446
ENST00000454652ENST00000305768KLHL24chr3183369064+CEP89chr1933392318-0.0012267930.99877316
ENST00000476808ENST00000305768KLHL24chr3183369064+CEP89chr1933392318-0.0017154930.9982845

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Fusion Genomic Features for KLHL24-CEP89


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLHL24-CEP89


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183369064/chr19:33392318)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLHL24

Q6TFL4

CEP89

Q96ST8

FUNCTION: Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (PubMed:27889062). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (PubMed:27798626). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). {ECO:0000250|UniProtKB:Q56A24, ECO:0000269|PubMed:27798626, ECO:0000269|PubMed:27889062}.FUNCTION: Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38168_270306601.0DomainNote=BACK
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+3866_133306601.0DomainBTB
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49168_270306601.0DomainNote=BACK
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+4966_133306601.0DomainBTB
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15168_270306538.0DomainNote=BACK
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+1566_133306538.0DomainBTB
TgeneCEP89chr3:183369064chr19:33392318ENST0000059059709234_3330357.0Coiled coilOntology_term=ECO:0000255
TgeneCEP89chr3:183369064chr19:33392318ENST0000059059709369_7190357.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38314_363306601.0RepeatNote=Kelch 1
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38365_407306601.0RepeatNote=Kelch 2
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38408_454306601.0RepeatNote=Kelch 3
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38456_502306601.0RepeatNote=Kelch 4
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38504_544306601.0RepeatNote=Kelch 5
HgeneKLHL24chr3:183369064chr19:33392318ENST00000242810+38546_592306601.0RepeatNote=Kelch 6
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49314_363306601.0RepeatNote=Kelch 1
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49365_407306601.0RepeatNote=Kelch 2
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49408_454306601.0RepeatNote=Kelch 3
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49456_502306601.0RepeatNote=Kelch 4
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49504_544306601.0RepeatNote=Kelch 5
HgeneKLHL24chr3:183369064chr19:33392318ENST00000454652+49546_592306601.0RepeatNote=Kelch 6
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15314_363306538.0RepeatNote=Kelch 1
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15365_407306538.0RepeatNote=Kelch 2
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15408_454306538.0RepeatNote=Kelch 3
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15456_502306538.0RepeatNote=Kelch 4
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15504_544306538.0RepeatNote=Kelch 5
HgeneKLHL24chr3:183369064chr19:33392318ENST00000476808+15546_592306538.0RepeatNote=Kelch 6
TgeneCEP89chr3:183369064chr19:33392318ENST000003057681319234_333521784.0Coiled coilOntology_term=ECO:0000255
TgeneCEP89chr3:183369064chr19:33392318ENST000003057681319369_719521784.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for KLHL24-CEP89


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>42971_42971_1_KLHL24-CEP89_KLHL24_chr3_183369064_ENST00000242810_CEP89_chr19_33392318_ENST00000305768_length(transcript)=2223nt_BP=1270nt
GGCCAGGGTTCGCTGACGCTCAGTGTTTTGGCCCGGACGGTCACATGTTTCCTTTGTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGA
GACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTTAGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAG
GTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGTGTGGAAATTAAAAGAACACACATATTTTGACTGGGGCTTTGA
TCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAACAATTATATAGTCAACTGATGTAACAATGGTACTAA
TATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTC
TGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGTGATAGCCGCT
TATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTA
TGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATG
TTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATG
CATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTCAAAACACTCT
TCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGATGAACTTATTG
ATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGA
GAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAAGTGGACCAAT
TGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCCCCAAGGACTA
GGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTGCAAGCGCAGA
AGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAAATCAATAGGA
AATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTGGCAAACCTTG
TTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGAGTGCTTAATA
AAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTGGGGGACATCA
GTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAGGTGCTGAAGG
ACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACCTTCAGGGAAA
ACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCCAGCCTCAATG
GCGTCTCTCAGGCAGACCTGCTGGACGGCTGCGATGTCTGCTCCTATGACCTGAAGTCTCATGCCCCCACCTGCTAGAATCTGCGGGAGC
CCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTGCAGGGCAGCCCATGGTGGCAGCCGGAGGTGCGTAAG

>42971_42971_1_KLHL24-CEP89_KLHL24_chr3_183369064_ENST00000242810_CEP89_chr19_33392318_ENST00000305768_length(amino acids)=568AA_BP=306
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK
INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKL
GDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAP

--------------------------------------------------------------
>42971_42971_2_KLHL24-CEP89_KLHL24_chr3_183369064_ENST00000454652_CEP89_chr19_33392318_ENST00000305768_length(transcript)=2259nt_BP=1306nt
GTTGTGAGCTGCGGCAGAGACTGGTGGCTGGAGGAGACGCCGGCGCTGGAGAGTGCGCTGCGCCGCCCGCCGCTGAGGGACCGCGGGGTT
AGCCACTGCTGGCTGCTTCCAGTGTTCGCCGAGAGGTACCGGGGGTGACAGCTCCGGGACCGGCCGAAAGGCGAGGAACCGGAAGCCCGG
GGGAGTGCGACCGCCTCAAATCCAGCCTTCTTGTTTGGTGGGACGACCGTCGGTTCTGTCCGGGAGGAATGACGGGGTCAAGGTGTGGAA
ATTAAAAGAACACACATATTTTGACTGGGGCTTTGATCAACCAAATGCTAAAAAGCCACATAAAGAAGATCCCTAATAGTCATTTCTCAA
CAATTATATAGTCAACTGATGTAACAATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAA
CTAAGCGAAAAGTTTTTGAAATGGACCCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACA
TACTCCAGATATTTAATGAATTTCGTGATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAG
CTGTGCTCTCAGCCTGTAGCAGCTACTTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTA
TTTTAGCTGAAGCTATGGAATGTTTTTTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGA
CATCAAGCCTCTTTCAGATTAGTGTTCTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCC
AGCGCTTTGCTGATACCCATTCACTCAAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACG
AAGAATTTCTTGAGCTTGACAAAGATGAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAG
CCGTCATGCGTTGGGTCTATCGTGCCGTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATC
CCAACTACTTTGTTCAAACAGTTGAAGTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACC
ACATACTTGGGAATGAAATGATGTCCCCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGG
AGTTGATGGAGAAGCTGACAGTCCTGCAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGG
AAGCCGAACTTGAACGAGCACAGAAAATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGA
ACGAAATGTCTGCTCATCAGTACCTGGCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAA
AATGTTTAGAAAGTGAGAAGGATGGAGTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCT
ACAAGAAGCAGGCAGCACTGAAGCTGGGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACC
GGCAGGAGATGCGGCACCTGCACCAGGTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTG
AACTTGAAGTTATTTGGGAATCTACCTTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGG
ACAACCCCAGAGCTCTGGTTGCCCCCAGCCTCAATGGCGTCTCTCAGGCAGACCTGCTGGACGGCTGCGATGTCTGCTCCTATGACCTGA
AGTCTCATGCCCCCACCTGCTAGAATCTGCGGGAGCCCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTG
CAGGGCAGCCCATGGTGGCAGCCGGAGGTGCGTAAGCCCACTGAACGCTGCAGGGCAGGGAAGAAATAAATGGTCTCATAGTTTAATCCA

>42971_42971_2_KLHL24-CEP89_KLHL24_chr3_183369064_ENST00000454652_CEP89_chr19_33392318_ENST00000305768_length(amino acids)=568AA_BP=306
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK
INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKL
GDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAP

--------------------------------------------------------------
>42971_42971_3_KLHL24-CEP89_KLHL24_chr3_183369064_ENST00000476808_CEP89_chr19_33392318_ENST00000305768_length(transcript)=1873nt_BP=920nt
ATGGTACTAATATTGGGACGCAGACTAAACAGAGAGGATCTTGGGGTGCGTGATTCCCCAGCAACTAAGCGAAAAGTTTTTGAAATGGAC
CCCAAATCTCTGACAGGTCATGAGTTTTTTGACTTCTCTTCAGGATCATCCCATGCCGAAAACATACTCCAGATATTTAATGAATTTCGT
GATAGCCGCTTATTCACAGATGTTATCATTTGTGTGGAAGGAAAAGAATTTCCTTGCCATAGAGCTGTGCTCTCAGCCTGTAGCAGCTAC
TTCAGAGCTATGTTTTGTAATGACCACAGGGAAAGCCGAGAAATGTTGGTTGAGATCAATGGTATTTTAGCTGAAGCTATGGAATGTTTT
TTGCAGTATGTTTATACTGGAAAGGTGAAGATCACTACAGAGAATGTACAGTATCTCTTTGAGACATCAAGCCTCTTTCAGATTAGTGTT
CTCCGTGATGCATGTGCCAAGTTCTTGGAGGAGCAACTTGATCCTTGTAATTGCTTAGGAATCCAGCGCTTTGCTGATACCCATTCACTC
AAAACACTCTTCACAAAATGCAAAAATTTTGCGTTACAGACTTTTGAGGATGTATCCCAGCACGAAGAATTTCTTGAGCTTGACAAAGAT
GAACTTATTGATTATATTTGTAGTGATGAACTTGTTATTGGTAAAGAGGAGATGGTTTTTGAAGCCGTCATGCGTTGGGTCTATCGTGCC
GTTGATCTGAGAAGACCACTGTTACACGAGCTCCTGACACATGTGAGACTCCCTCTGTTGCATCCCAACTACTTTGTTCAAACAGTTGAA
GTGGACCAATTGATCCAGAATTCTCCTGAGTGTTATCAGTTGTTGCATGAAGCAAGACGGTACCACATACTTGGGAATGAAATGATGTCC
CCAAGGACTAGGCCACGCAGCCAATTACAGAAGGAAGAAGAGAAAGAAAGGGCTGAGATGGAGGAGTTGATGGAGAAGCTGACAGTCCTG
CAAGCGCAGAAGAAGAGCCTGCTGTTAGAGAAGAACAGTTTGACAGAGCAAAACAAAGCACTGGAAGCCGAACTTGAACGAGCACAGAAA
ATCAATAGGAAATCTCAAAAGAAAATTGAGGTCCTCAAAAAGCAGGTGGAAAAAGCCATGGGGAACGAAATGTCTGCTCATCAGTACCTG
GCAAACCTTGTTGGCCTGGCAGAAAACATAACCCAGGAACGTGACAGTCTTATGTGTTTGGCAAAATGTTTAGAAAGTGAGAAGGATGGA
GTGCTTAATAAAGTCATAAAAAGCAACATTCGCCTGGGAAAGTTAGAGGAAAAAGTCAAGGGCTACAAGAAGCAGGCAGCACTGAAGCTG
GGGGACATCAGTCACCGTCTGCTGGAGCAGCAGGAGGACTTCGCCGGCAAGACAGCCCAGTACCGGCAGGAGATGCGGCACCTGCACCAG
GTGCTGAAGGACAAGCAGGAGGTGCTGGACCAGGCGCTGCAGCAGAACAGAGAAATGGAAGGTGAACTTGAAGTTATTTGGGAATCTACC
TTCAGGGAAAACCGAAGAATCCGAGAACTTCTCCAGGACACACTCACGAGGACAGGCGTGCAGGACAACCCCAGAGCTCTGGTTGCCCCC
AGCCTCAATGGCGTCTCTCAGGCAGACCTGCTGGACGGCTGCGATGTCTGCTCCTATGACCTGAAGTCTCATGCCCCCACCTGCTAGAAT
CTGCGGGAGCCCGTGGTGTAGCCTCCTCTGGCCTGAAAGGTCTGCCTCACACAGGCCTTCCCTGCAGGGCAGCCCATGGTGGCAGCCGGA

>42971_42971_3_KLHL24-CEP89_KLHL24_chr3_183369064_ENST00000476808_CEP89_chr19_33392318_ENST00000305768_length(amino acids)=568AA_BP=306
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSY
FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE
VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK
INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKL
GDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQDNPRALVAP

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Fusion Gene PPI Analysis for KLHL24-CEP89


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLHL24-CEP89


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLHL24-CEP89


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource