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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLHL5-HLA-F (FusionGDB2 ID:43022)

Fusion Gene Summary for KLHL5-HLA-F

Fusion gene summary

Fusion gene information	Fusion gene name: KLHL5-HLA-F
	Fusion gene ID: 43022
		Hgene	Tgene
	Gene symbol	KLHL5	HLA-F
	Gene ID	51088	3134
	Gene name	kelch like family member 5	major histocompatibility complex, class I, F
	Synonyms	-	CDA12\|HLA-5.4\|HLA-CDA12\|HLAF
	Cytomap	4p14	6p22.1
	Type of gene	protein-coding	protein-coding
	Description	kelch-like protein 5lymphocyte activation-associated protein	HLA class I histocompatibility antigen, alpha chain FHLA F antigenMHC class I antigen Fleukocyte antigen F
	Modification date	20200327	20200313
	UniProtAcc	.	P30511
	Ensembl transtripts involved in fusion gene	ENST00000261425, ENST00000261426, ENST00000359687, ENST00000381930, ENST00000504108, ENST00000508137,	ENST00000440587, ENST00000259951, ENST00000334668, ENST00000342322, ENST00000359076, ENST00000376848, ENST00000376861, ENST00000383515, ENST00000383516, ENST00000383626, ENST00000383627, ENST00000420067, ENST00000422439, ENST00000422711, ENST00000428296, ENST00000430472, ENST00000434407, ENST00000435058, ENST00000440590, ENST00000444891, ENST00000445657, ENST00000463731, ENST00000475996, ENST00000485297, ENST00000489167, ENST00000490259, ENST00000490874, ENST00000496199, ENST00000547132, ENST00000549067, ENST00000549254, ENST00000549422, ENST00000550932, ENST00000551026, ENST00000551347, ENST00000551780, ENST00000551832, ENST00000552082, ENST00000552880,
Fusion gene scores	* DoF score	10 X 7 X 6=420	2 X 2 X 2=8
	# samples	11	2
	** MAII score	log2(11/420*10)=-1.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: KLHL5 [Title/Abstract] AND HLA-F [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLHL5(39128477)-HLA-F(29705899), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HLA-F	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	28636952
Tgene	HLA-F	GO:0002477	antigen processing and presentation of exogenous peptide antigen via MHC class Ib	23851683
Tgene	HLA-F	GO:0002725	negative regulation of T cell cytokine production	24018270
Tgene	HLA-F	GO:0002728	negative regulation of natural killer cell cytokine production	24018270
Tgene	HLA-F	GO:0002729	positive regulation of natural killer cell cytokine production	27455421
Tgene	HLA-F	GO:0043322	negative regulation of natural killer cell degranulation	24018270
Tgene	HLA-F	GO:0043323	positive regulation of natural killer cell degranulation	27455421
Tgene	HLA-F	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	24018270
Tgene	HLA-F	GO:1901215	negative regulation of neuron death	26928464

Fusion gene breakpoints across KLHL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLA-F (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A4NO-01A	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+

Top

Fusion Gene ORF analysis for KLHL5-HLA-F

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000261425	ENST00000440587	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000261426	ENST00000440587	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000359687	ENST00000440587	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000381930	ENST00000440587	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000504108	ENST00000440587	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-3UTR	ENST00000508137	ENST00000440587	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000259951	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000334668	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000342322	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000359076	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000376848	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000376861	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383515	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383516	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383626	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000383627	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000420067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000422439	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000422711	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000428296	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000430472	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000434407	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000435058	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000440590	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000444891	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000445657	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000463731	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000475996	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000485297	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000489167	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000490259	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000490874	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000496199	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000547132	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000549067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000549254	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000549422	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000550932	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551026	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551347	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551780	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000551832	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000552082	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261425	ENST00000552880	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000259951	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000334668	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000342322	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000359076	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000376848	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000376861	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383515	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383516	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383626	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000383627	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000420067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000422439	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000422711	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000428296	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000430472	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000434407	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000435058	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000440590	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000444891	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000445657	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000463731	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000475996	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000485297	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000489167	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000490259	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000490874	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000496199	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000547132	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000549067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000549254	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000549422	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000550932	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551026	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551347	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551780	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000551832	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000552082	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000261426	ENST00000552880	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000259951	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000334668	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000342322	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000359076	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000376848	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000376861	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383515	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383516	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383626	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000383627	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000420067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000422439	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000422711	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000428296	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000430472	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000434407	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000435058	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000440590	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000444891	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000445657	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000463731	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000475996	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000485297	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000489167	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000490259	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000490874	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000496199	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000547132	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000549067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000549254	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000549422	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000550932	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551026	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551347	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551780	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000551832	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000552082	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000359687	ENST00000552880	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000259951	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000334668	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000342322	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000359076	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000376848	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000376861	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383515	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383516	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383626	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000383627	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000420067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000422439	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000422711	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000428296	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000430472	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000434407	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000435058	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000440590	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000444891	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000445657	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000463731	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000475996	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000485297	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000489167	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000490259	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000490874	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000496199	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000547132	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000549067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000549254	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000549422	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000550932	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551026	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551347	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551780	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000551832	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000552082	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000381930	ENST00000552880	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000259951	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000334668	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000342322	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000359076	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000376848	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000376861	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383515	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383516	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383626	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000383627	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000420067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000422439	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000422711	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000428296	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000430472	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000434407	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000435058	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000440590	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000444891	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000445657	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000463731	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000475996	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000485297	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000489167	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000490259	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000490874	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000496199	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000547132	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000549067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000549254	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000549422	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000550932	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551026	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551347	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551780	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000551832	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000552082	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000504108	ENST00000552880	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000259951	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000334668	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000342322	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000359076	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000376848	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000376861	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383515	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383516	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383626	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000383627	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000420067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000422439	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000422711	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000428296	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000430472	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000434407	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000435058	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000440590	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000444891	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000445657	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000463731	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000475996	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000485297	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000489167	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000490259	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000490874	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000496199	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000547132	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000549067	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000549254	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000549422	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000550932	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551026	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551347	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551780	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000551832	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000552082	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+
intron-intron	ENST00000508137	ENST00000552880	KLHL5	chr4	39128477	-	HLA-F	chr6	29705899	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for KLHL5-HLA-F

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLHL5-HLA-F

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39128477/:29705899)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HLA-F P30511
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269\|PubMed:23851683, ECO:0000269\|PubMed:24018270, ECO:0000269\|PubMed:26928464, ECO:0000269\|PubMed:27455421, ECO:0000269\|PubMed:28636952}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for KLHL5-HLA-F

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KLHL5-HLA-F

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KLHL5-HLA-F

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KLHL5-HLA-F

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source