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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC5-VDAC3 (FusionGDB2 ID:4303)

Fusion Gene Summary for ANAPC5-VDAC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC5-VDAC3
Fusion gene ID: 4303
HgeneTgene
Gene symbol

ANAPC5

VDAC3

Gene ID

51433

7419

Gene nameanaphase promoting complex subunit 5voltage dependent anion channel 3
SynonymsAPC5HD-VDAC3|VDAC-3
Cytomap

12q24.31

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 5cyclosome subunit 5voltage-dependent anion-selective channel protein 3outer mitochondrial membrane protein porin 3
Modification date2020031320200313
UniProtAcc

Q9UJX4

.
Ensembl transtripts involved in fusion geneENST00000261819, ENST00000541887, 
ENST00000441917, ENST00000344395, 
ENST00000535482, ENST00000536366, 
ENST00000544314, 		ENST00000022615, 
ENST00000521158, ENST00000522572, 
ENST00000392935, 
Fusion gene scores* DoF score9 X 11 X 6=5948 X 8 X 6=384
# samples 118
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/384*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC5 [Title/Abstract] AND VDAC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC5(121785604)-VDAC3(42260828), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC5

GO:0070979

protein K11-linked ubiquitination

18485873


check buttonFusion gene breakpoints across ANAPC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VDAC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NANAPC5chr12

121785604

-VDAC3chr8

42260828

+


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Fusion Gene ORF analysis for ANAPC5-VDAC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000261819ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5CDS-intronENST00000261819ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5CDS-intronENST00000261819ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5CDS-intronENST00000541887ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5CDS-intronENST00000541887ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5CDS-intronENST00000541887ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5UTR-3CDSENST00000441917ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5UTR-intronENST00000441917ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5UTR-intronENST00000441917ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
5UTR-intronENST00000441917ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
In-frameENST00000261819ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
In-frameENST00000541887ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-3CDSENST00000344395ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-3CDSENST00000535482ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-3CDSENST00000536366ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-3CDSENST00000544314ENST00000392935ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000344395ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000344395ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000344395ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000535482ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000535482ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000535482ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000536366ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000536366ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000536366ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000544314ENST00000022615ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000544314ENST00000521158ANAPC5chr12

121785604

-VDAC3chr8

42260828

+
intron-intronENST00000544314ENST00000522572ANAPC5chr12

121785604

-VDAC3chr8

42260828

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541887ANAPC5chr12121785604-ENST00000392935VDAC3chr842260828+106733548635195
ENST00000261819ANAPC5chr12121785604-ENST00000392935VDAC3chr842260828+1141409122709195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541887ENST00000392935ANAPC5chr12121785604-VDAC3chr842260828+0.0016946340.9983053
ENST00000261819ENST00000392935ANAPC5chr12121785604-VDAC3chr842260828+0.0014979010.99850214

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Fusion Genomic Features for ANAPC5-VDAC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANAPC5chr12121785604-VDAC3chr842260828+7.43E-060.9999926
ANAPC5chr12121785604-VDAC3chr842260828+7.43E-060.9999926

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANAPC5-VDAC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121785604/chr8:42260828)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC5

Q9UJX4

.
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610242_244183284.0Nucleotide bindingNAD
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610260_264183284.0Nucleotide bindingNAD
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711242_244184285.0Nucleotide bindingNAD
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711260_264184285.0Nucleotide bindingNAD
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610189_198183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610202_211183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610218_227183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610231_238183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610242_251183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610254_263183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610273_282183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711189_198184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711202_211184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711218_227184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711231_238184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711242_251184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711254_263184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711273_282184285.0TransmembraneBeta stranded

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217209_24995756.0RepeatNote=TPR 1
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217250_30095756.0RepeatNote=TPR 2
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217301_33795756.0RepeatNote=TPR 3
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217338_37895756.0RepeatNote=TPR 4
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217379_41895756.0RepeatNote=TPR 5
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217419_46695756.0RepeatNote=TPR 6
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217467_50095756.0RepeatNote=TPR 7
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217501_54095756.0RepeatNote=TPR 8
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217541_58095756.0RepeatNote=TPR 9
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217581_62095756.0RepeatNote=TPR 10
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217621_66095756.0RepeatNote=TPR 11
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217661_69695756.0RepeatNote=TPR 12
HgeneANAPC5chr12:121785604chr8:42260828ENST00000261819-217697_73695756.0RepeatNote=TPR 13
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115209_2490644.0RepeatNote=TPR 1
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115250_3000644.0RepeatNote=TPR 2
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115301_3370644.0RepeatNote=TPR 3
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115338_3780644.0RepeatNote=TPR 4
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115379_4180644.0RepeatNote=TPR 5
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115419_4660644.0RepeatNote=TPR 6
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115467_5000644.0RepeatNote=TPR 7
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115501_5400644.0RepeatNote=TPR 8
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115541_5800644.0RepeatNote=TPR 9
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115581_6200644.0RepeatNote=TPR 10
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115621_6600644.0RepeatNote=TPR 11
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115661_6960644.0RepeatNote=TPR 12
HgeneANAPC5chr12:121785604chr8:42260828ENST00000344395-115697_7360644.0RepeatNote=TPR 13
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116209_2490644.0RepeatNote=TPR 1
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116250_3000644.0RepeatNote=TPR 2
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116301_3370644.0RepeatNote=TPR 3
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116338_3780644.0RepeatNote=TPR 4
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116379_4180644.0RepeatNote=TPR 5
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116419_4660644.0RepeatNote=TPR 6
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116467_5000644.0RepeatNote=TPR 7
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116501_5400644.0RepeatNote=TPR 8
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116541_5800644.0RepeatNote=TPR 9
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116581_6200644.0RepeatNote=TPR 10
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116621_6600644.0RepeatNote=TPR 11
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116661_6960644.0RepeatNote=TPR 12
HgeneANAPC5chr12:121785604chr8:42260828ENST00000441917-116697_7360644.0RepeatNote=TPR 13
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15209_2490220.0RepeatNote=TPR 1
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15250_3000220.0RepeatNote=TPR 2
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15301_3370220.0RepeatNote=TPR 3
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15338_3780220.0RepeatNote=TPR 4
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15379_4180220.0RepeatNote=TPR 5
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15419_4660220.0RepeatNote=TPR 6
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15467_5000220.0RepeatNote=TPR 7
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15501_5400220.0RepeatNote=TPR 8
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15541_5800220.0RepeatNote=TPR 9
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15581_6200220.0RepeatNote=TPR 10
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15621_6600220.0RepeatNote=TPR 11
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15661_6960220.0RepeatNote=TPR 12
HgeneANAPC5chr12:121785604chr8:42260828ENST00000536366-15697_7360220.0RepeatNote=TPR 13
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610111_120183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610123_130183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610137_145183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610150_158183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610163_175183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000022615610178_185183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000002261561026_35183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000002261561039_47183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000002261561054_64183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000002261561069_76183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000002261561080_89183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000002261561095_104183284.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711111_120184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711123_130184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711137_145184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711150_158184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711163_175184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST00000521158711178_185184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000052115871126_35184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000052115871139_47184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000052115871154_64184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000052115871169_76184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000052115871180_89184285.0TransmembraneBeta stranded
TgeneVDAC3chr12:121785604chr8:42260828ENST0000052115871195_104184285.0TransmembraneBeta stranded


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Fusion Gene Sequence for ANAPC5-VDAC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4303_4303_1_ANAPC5-VDAC3_ANAPC5_chr12_121785604_ENST00000261819_VDAC3_chr8_42260828_ENST00000392935_length(transcript)=1141nt_BP=409nt
GCGGATGTCTGTTTCCTGGGATATTGTGAGGGCGGGCGGAGATGTAGACCCGGTAGTGTTGTGCCTTGTGGTGACAACTGGCGGCAGCGC
GCCGCGGGCCCGAGACTTAGTCTCGGGCCGCCATGGCCAGCGTCCACGAGAGCCTCTACTTCAATCCCATGATGACCAATGGGGTTGTGC
ACGCCAATGTGTTCGGCATCAAGGACTGGGTGACGCCGTACAAGATCGCGGTGCTGGTGCTGCTGAACGAGATGAGCCGCACAGGCGAGG
GCGCCGTCAGCCTCATGGAGCGGCGGAGGCTCAACCAGCTGCTCCTGCCCCTGCTGCAGGGCCCAGATATTACACTGTCAAAACTTTACA
AGTTAATTGAAGAGTCTTGTCCACAGCTGGCAAATTCAGTGCAGATCAGGAACGATGGCACTGAATTTGGAGGTTCTATCTACCAGAAGG
TGAATGAGAAGATTGAAACATCCATAAACCTTGCTTGGACAGCTGGGAGTAACAACACCCGTTTTGGCATTGCTGCTAAGTACATGCTGG
ATTGTAGAACTTCTCTCTCTGCTAAAGTAAATAATGCCAGCCTGATTGGACTGGGTTATACTCAGACCCTTCGACCAGGAGTCAAATTGA
CTTTATCAGCTTTAATCGATGGGAAGAACTTCAGTGCAGGAGGTCACAAGGTTGGCTTGGGATTTGAACTGGAAGCTTAATGTGGTTTGA
GGAAAGCATCAGATTTGTCCCTGGAAGTGAAGAGAAATGAACCCACTATGTTTTGGCCTTAAAATTCTTCTGTGAAATTTCAAAAGTGTG
AACTTTTTATTCTTCCAAAGAATTGTAATCCTCCCCACACTGAAGTCTAGGGGTTGCGAATCCCTCCTGAGGGAGATGCTTGAAGGCATG
CCTGGAAGTTGTCATGTTTGTGCCACGTTTCAGTTCAGTTCTGAAGTGTTATTAAATGTGTTCCTCAGCGACAGTGTAGCGTCATGTTAG
AGGAGACGATCTGACCCACCAGTTTGTACATCACGTCCTGCATGTCCCACACCATTTTTTCATGACCTTGTAATATACTGGTCTCTGTGC

>4303_4303_1_ANAPC5-VDAC3_ANAPC5_chr12_121785604_ENST00000261819_VDAC3_chr8_42260828_ENST00000392935_length(amino acids)=195AA_BP=95
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLA
NSVQIRNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNF

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>4303_4303_2_ANAPC5-VDAC3_ANAPC5_chr12_121785604_ENST00000541887_VDAC3_chr8_42260828_ENST00000392935_length(transcript)=1067nt_BP=335nt
CAACTGGCGGCAGCGCGCCGCGGGCCCGAGACTTAGTCTCGGGCCGCCATGGCCAGCGTCCACGAGAGCCTCTACTTCAATCCCATGATG
ACCAATGGGGTTGTGCACGCCAATGTGTTCGGCATCAAGGACTGGGTGACGCCGTACAAGATCGCGGTGCTGGTGCTGCTGAACGAGATG
AGCCGCACAGGCGAGGGCGCCGTCAGCCTCATGGAGCGGCGGAGGCTCAACCAGCTGCTCCTGCCCCTGCTGCAGGGCCCAGATATTACA
CTGTCAAAACTTTACAAGTTAATTGAAGAGTCTTGTCCACAGCTGGCAAATTCAGTGCAGATCAGGAACGATGGCACTGAATTTGGAGGT
TCTATCTACCAGAAGGTGAATGAGAAGATTGAAACATCCATAAACCTTGCTTGGACAGCTGGGAGTAACAACACCCGTTTTGGCATTGCT
GCTAAGTACATGCTGGATTGTAGAACTTCTCTCTCTGCTAAAGTAAATAATGCCAGCCTGATTGGACTGGGTTATACTCAGACCCTTCGA
CCAGGAGTCAAATTGACTTTATCAGCTTTAATCGATGGGAAGAACTTCAGTGCAGGAGGTCACAAGGTTGGCTTGGGATTTGAACTGGAA
GCTTAATGTGGTTTGAGGAAAGCATCAGATTTGTCCCTGGAAGTGAAGAGAAATGAACCCACTATGTTTTGGCCTTAAAATTCTTCTGTG
AAATTTCAAAAGTGTGAACTTTTTATTCTTCCAAAGAATTGTAATCCTCCCCACACTGAAGTCTAGGGGTTGCGAATCCCTCCTGAGGGA
GATGCTTGAAGGCATGCCTGGAAGTTGTCATGTTTGTGCCACGTTTCAGTTCAGTTCTGAAGTGTTATTAAATGTGTTCCTCAGCGACAG
TGTAGCGTCATGTTAGAGGAGACGATCTGACCCACCAGTTTGTACATCACGTCCTGCATGTCCCACACCATTTTTTCATGACCTTGTAAT

>4303_4303_2_ANAPC5-VDAC3_ANAPC5_chr12_121785604_ENST00000541887_VDAC3_chr8_42260828_ENST00000392935_length(amino acids)=195AA_BP=95
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLA
NSVQIRNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNF

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Fusion Gene PPI Analysis for ANAPC5-VDAC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC5-VDAC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC5-VDAC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource