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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLK2-PVRL2 (FusionGDB2 ID:43067)

Fusion Gene Summary for KLK2-PVRL2

check button Fusion gene summary
Fusion gene informationFusion gene name: KLK2-PVRL2
Fusion gene ID: 43067
HgeneTgene
Gene symbol

KLK2

PVRL2

Gene ID

3817

5819

Gene namekallikrein related peptidase 2nectin cell adhesion molecule 2
SynonymsKLK2A2|hGK-1|hK2CD112|HVEB|PRR2|PVRL2|PVRR2
Cytomap

19q13.33

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionkallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2nectin-2herpesvirus entry protein Bpoliovirus receptor-like 2poliovirus receptor-related 2 (herpesvirus entry mediator B)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000391810, ENST00000325321, 
ENST00000358049, ENST00000597509, 
ENST00000252483, ENST00000252485, 
Fusion gene scores* DoF score21 X 19 X 4=15968 X 6 X 7=336
# samples 3012
** MAII scorelog2(30/1596*10)=-2.41142624572647
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/336*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLK2 [Title/Abstract] AND PVRL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLK2(51376775)-PVRL2(45368527), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePVRL2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

9845526

TgenePVRL2

GO:0019064

fusion of virus membrane with host plasma membrane

12915581

TgenePVRL2

GO:0044406

adhesion of symbiont to host

12915581

TgenePVRL2

GO:0046596

regulation of viral entry into host cell

11602758

TgenePVRL2

GO:0046814

coreceptor-mediated virion attachment to host cell

12915581

TgenePVRL2

GO:0050862

positive regulation of T cell receptor signaling pathway

26755705

TgenePVRL2

GO:0060370

susceptibility to T cell mediated cytotoxicity

15039383


check buttonFusion gene breakpoints across KLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PVRL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-7509-01AKLK2chr19

51376774

+PVRL2chr19

45368527

+
ChimerDB4PRADTCGA-G9-7509KLK2chr19

51376775

+PVRL2chr19

45368527

+
ChimerDB4PRADTCGA-G9-7509KLK2chr19

51376775

+PVRL2chr19

45368528

+


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Fusion Gene ORF analysis for KLK2-PVRL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000391810ENST00000252483KLK2chr19

51376774

+PVRL2chr19

45368527

+
5UTR-3CDSENST00000391810ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368527

+
5UTR-3CDSENST00000391810ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368528

+
5UTR-3CDSENST00000391810ENST00000252485KLK2chr19

51376774

+PVRL2chr19

45368527

+
5UTR-3CDSENST00000391810ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368527

+
5UTR-3CDSENST00000391810ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368528

+
In-frameENST00000325321ENST00000252483KLK2chr19

51376774

+PVRL2chr19

45368527

+
In-frameENST00000325321ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368527

+
In-frameENST00000325321ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368528

+
In-frameENST00000325321ENST00000252485KLK2chr19

51376774

+PVRL2chr19

45368527

+
In-frameENST00000325321ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368527

+
In-frameENST00000325321ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368528

+
In-frameENST00000358049ENST00000252483KLK2chr19

51376774

+PVRL2chr19

45368527

+
In-frameENST00000358049ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368527

+
In-frameENST00000358049ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368528

+
In-frameENST00000358049ENST00000252485KLK2chr19

51376774

+PVRL2chr19

45368527

+
In-frameENST00000358049ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368527

+
In-frameENST00000358049ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368528

+
intron-3CDSENST00000597509ENST00000252483KLK2chr19

51376774

+PVRL2chr19

45368527

+
intron-3CDSENST00000597509ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368527

+
intron-3CDSENST00000597509ENST00000252483KLK2chr19

51376775

+PVRL2chr19

45368528

+
intron-3CDSENST00000597509ENST00000252485KLK2chr19

51376774

+PVRL2chr19

45368527

+
intron-3CDSENST00000597509ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368527

+
intron-3CDSENST00000597509ENST00000252485KLK2chr19

51376775

+PVRL2chr19

45368528

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325321KLK2chr1951376775+ENST00000252485PVRL2chr1945368527+1944271271622531
ENST00000325321KLK2chr1951376775+ENST00000252483PVRL2chr1945368527+2649271271799590
ENST00000358049KLK2chr1951376775+ENST00000252485PVRL2chr1945368527+173562161413465
ENST00000358049KLK2chr1951376775+ENST00000252483PVRL2chr1945368527+244062161590524
ENST00000325321KLK2chr1951376775+ENST00000252485PVRL2chr1945368528+1944271271622531
ENST00000325321KLK2chr1951376775+ENST00000252483PVRL2chr1945368528+2649271271799590
ENST00000358049KLK2chr1951376775+ENST00000252485PVRL2chr1945368528+173562161413465
ENST00000358049KLK2chr1951376775+ENST00000252483PVRL2chr1945368528+244062161590524
ENST00000325321KLK2chr1951376774+ENST00000252485PVRL2chr1945368527+1944271271622531
ENST00000325321KLK2chr1951376774+ENST00000252483PVRL2chr1945368527+2649271271799590
ENST00000358049KLK2chr1951376774+ENST00000252485PVRL2chr1945368527+173562161413465
ENST00000358049KLK2chr1951376774+ENST00000252483PVRL2chr1945368527+244062161590524

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325321ENST00000252485KLK2chr1951376775+PVRL2chr1945368527+0.0118784920.9881215
ENST00000325321ENST00000252483KLK2chr1951376775+PVRL2chr1945368527+0.0057479220.9942521
ENST00000358049ENST00000252485KLK2chr1951376775+PVRL2chr1945368527+0.0118115550.98818845
ENST00000358049ENST00000252483KLK2chr1951376775+PVRL2chr1945368527+0.0054277930.9945722
ENST00000325321ENST00000252485KLK2chr1951376775+PVRL2chr1945368528+0.0118784920.9881215
ENST00000325321ENST00000252483KLK2chr1951376775+PVRL2chr1945368528+0.0057479220.9942521
ENST00000358049ENST00000252485KLK2chr1951376775+PVRL2chr1945368528+0.0118115550.98818845
ENST00000358049ENST00000252483KLK2chr1951376775+PVRL2chr1945368528+0.0054277930.9945722
ENST00000325321ENST00000252485KLK2chr1951376774+PVRL2chr1945368527+0.0118784920.9881215
ENST00000325321ENST00000252483KLK2chr1951376774+PVRL2chr1945368527+0.0057479220.9942521
ENST00000358049ENST00000252485KLK2chr1951376774+PVRL2chr1945368527+0.0118115550.98818845
ENST00000358049ENST00000252483KLK2chr1951376774+PVRL2chr1945368527+0.0054277930.9945722

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Fusion Genomic Features for KLK2-PVRL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KLK2chr1951376775+PVRL2chr1945368527+4.97E-060.999995
KLK2chr1951376775+PVRL2chr1945368527+4.97E-060.999995
KLK2chr1951376775+PVRL2chr1945368527+4.97E-060.999995
KLK2chr1951376775+PVRL2chr1945368527+4.97E-060.999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KLK2-PVRL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51376775/chr19:45368527)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248309162_25629539.0DomainNote=Ig-like C2-type 1
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248309261_34529539.0DomainNote=Ig-like C2-type 2
TgenePVRL2chr19:51376774chr19:45368527ENST000002524830932_15629539.0DomainNote=Ig-like V-type
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248506162_25629480.0DomainNote=Ig-like C2-type 1
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248506261_34529480.0DomainNote=Ig-like C2-type 2
TgenePVRL2chr19:51376774chr19:45368527ENST000002524850632_15629480.0DomainNote=Ig-like V-type
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248309162_25629539.0DomainNote=Ig-like C2-type 1
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248309261_34529539.0DomainNote=Ig-like C2-type 2
TgenePVRL2chr19:51376775chr19:45368527ENST000002524830932_15629539.0DomainNote=Ig-like V-type
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248506162_25629480.0DomainNote=Ig-like C2-type 1
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248506261_34529480.0DomainNote=Ig-like C2-type 2
TgenePVRL2chr19:51376775chr19:45368527ENST000002524850632_15629480.0DomainNote=Ig-like V-type
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248309162_25629539.0DomainNote=Ig-like C2-type 1
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248309261_34529539.0DomainNote=Ig-like C2-type 2
TgenePVRL2chr19:51376775chr19:45368528ENST000002524830932_15629539.0DomainNote=Ig-like V-type
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248506162_25629480.0DomainNote=Ig-like C2-type 1
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248506261_34529480.0DomainNote=Ig-like C2-type 2
TgenePVRL2chr19:51376775chr19:45368528ENST000002524850632_15629480.0DomainNote=Ig-like V-type
TgenePVRL2chr19:51376774chr19:45368527ENST000002524830932_36029539.0Topological domainExtracellular
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248309382_53829539.0Topological domainCytoplasmic
TgenePVRL2chr19:51376774chr19:45368527ENST000002524850632_36029480.0Topological domainExtracellular
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248506382_53829480.0Topological domainCytoplasmic
TgenePVRL2chr19:51376775chr19:45368527ENST000002524830932_36029539.0Topological domainExtracellular
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248309382_53829539.0Topological domainCytoplasmic
TgenePVRL2chr19:51376775chr19:45368527ENST000002524850632_36029480.0Topological domainExtracellular
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248506382_53829480.0Topological domainCytoplasmic
TgenePVRL2chr19:51376775chr19:45368528ENST000002524830932_36029539.0Topological domainExtracellular
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248309382_53829539.0Topological domainCytoplasmic
TgenePVRL2chr19:51376775chr19:45368528ENST000002524850632_36029480.0Topological domainExtracellular
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248506382_53829480.0Topological domainCytoplasmic
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248309361_38129539.0TransmembraneHelical
TgenePVRL2chr19:51376774chr19:45368527ENST0000025248506361_38129480.0TransmembraneHelical
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248309361_38129539.0TransmembraneHelical
TgenePVRL2chr19:51376775chr19:45368527ENST0000025248506361_38129480.0TransmembraneHelical
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248309361_38129539.0TransmembraneHelical
TgenePVRL2chr19:51376775chr19:45368528ENST0000025248506361_38129480.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLK2chr19:51376774chr19:45368527ENST00000325321+1525_25815262.0DomainPeptidase S1
HgeneKLK2chr19:51376774chr19:45368527ENST00000358049+1525_25815224.0DomainPeptidase S1
HgeneKLK2chr19:51376774chr19:45368527ENST00000391810+1425_2580160.0DomainPeptidase S1
HgeneKLK2chr19:51376775chr19:45368527ENST00000325321+1525_25815262.0DomainPeptidase S1
HgeneKLK2chr19:51376775chr19:45368527ENST00000358049+1525_25815224.0DomainPeptidase S1
HgeneKLK2chr19:51376775chr19:45368527ENST00000391810+1425_2580160.0DomainPeptidase S1
HgeneKLK2chr19:51376775chr19:45368528ENST00000325321+1525_25815262.0DomainPeptidase S1
HgeneKLK2chr19:51376775chr19:45368528ENST00000358049+1525_25815224.0DomainPeptidase S1
HgeneKLK2chr19:51376775chr19:45368528ENST00000391810+1425_2580160.0DomainPeptidase S1


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Fusion Gene Sequence for KLK2-PVRL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43067_43067_1_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000325321_PVRL2_chr19_45368527_ENST00000252483_length(transcript)=2649nt_BP=271nt
GATCTAGTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCCAGCCTCCAGCAGCA
TGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGAGAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCC
CCCCAGCCCCAAACTCACCACCTGGCCGTGGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACT
GGAGCCCAGGATGTGCGAGTTCAAGTGCTACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCT
GTTCCTGGACTGTACATCTCCCTGGTGACCTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATG
GGTCCCAGCTTCCCCAGCCCGAAGCCTGGCAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAG
CTCCAGGACGCCACGCTGGCCCTCCACGGGCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCC
GTCCGAGGGATGACCTGGCTCAGAGTCATAGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACA
GTGGCCCTCTGCATCTCCAAAGAGGGCCGCCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTG
TCAGGGACCCTGGCCGGAACTGTCACTGTCACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAA
GTGGAGCATGAGAGCTTCGAGGAACCAGCCCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGAT
GACAACTGGTACCTCGGCCGTACTGATGCCACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACC
TCAGGCACCTTCCCGACCTCCGCAGTGGCCCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGC
ACAGTCACCAATGCCGTGGGCATGGGCCGCGCTGAGCAGGTCATCTTTGTCCGAGAGACCCCCAACACAGCAGGCGCAGGGGCCACAGGC
GGCATCATCGGGGGCATCATCGCCGCCATCATTGCTACTGCTGTGGCTGCCACGGGCATCCTTATCTGCCGGCAGCAGCGGAAGGAGCAG
ACGCTGCAGGGGGCAGAGGAGGACGAAGACCTGGAGGGACCTCCCTCCTACAAGCCACCAACCCCAAAAGCGAAGCTGGAGGCACAGGAG
ATGCCCTCCCAGCTCTTCACTCTGGGGGCCTCGGAGCACAGCCCACTCAAGACCCCCTACTTTGATGCTGGCGCCTCATGCACTGAGCAG
GAAATGCCTCGATACCATGAGCTGCCCACCTTGGAAGAACGGTCAGGACCCTTGCACCCTGGAGCCACAAGCCTGGGGTCCCCCATCCCG
GTGCCTCCAGGGCCACCTGCTGTGGAAGACGTTTCCCTGGATCTAGAGGATGAGGAGGGGGAGGAGGAGGAAGAGTATCTGGACAAGATC
AACCCCATCTATGATGCTCTGTCCTATAGCAGCCCCTCTGATTCCTACCAGGGCAAAGGCTTTGTCATGTCCCGGGCCATGTATGTGTGA
GCTGCCATGCGCCTGGCGTCTCACATCTCACCTGTTGATCCCTTAGCTTTCTTGCCAAGGATCTAGTGCCCCCTGACCTCTGGCCAGGCC
ACTGTCAGTTAACACATATGCATTCCATTTGTGATGTCTACCTTGGTGGCTCCACTATGACCCCTAACCCATGAGCCCAGAGAAATTCAC
CGTGATAATGGAATCCTGGCAACCTTATCTCATGAGGCAGGAGGTGGGGAAGGTGCTTCTGCACAACCTCTGATCCCAAGGACTCCTCTC
CCAGACTGTGACCTTAGACCATACCTCTCACCCCCCAATGCCTCGACTCCCCCAAAATCACAAAGAAGACCCTAGACCTATAATTTGTCT
TCAGGTAGTAAATTCCCAATAGGTCTGCTGGAGTGGGCGCTGAGGGCTCCCTGCTGCTCAGACCTGAGCCCTCCAGGCAGCAGGGTCCCA
CTTACCCCCTCCCCACCCTGTTCCCCAAAGGTGGGAAAGAGGGGATTCCCCAGCCCAAGGCAGGGTTTTCCCAGCACCCTCCTGTAAGCA
GAAGTCTCAGGGTCCAGACCCTTCCCTGAGCCCCCACCCCCACCCCAATTCCTGCCTACCAAGCAAGCAGCCCCAGCCTAGGGTCAGACA
GGGTGAGCCTCATACAGACTGTGCCTTGATGGCCCCAGCCTTGGGAGAAGAATTTACTGTTAACCTGGAAGACTACTGAATCATTTTACC
CTTGCCCAGTGGAATAGGACCTAAACATCCCCCTTCCGGGGAAAGTGGGTCATCTGAATTGGGGGTAGCAATTGATACTGTTTTGTAAAC

>43067_43067_1_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000325321_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=590AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDE
DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVE

--------------------------------------------------------------
>43067_43067_2_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000325321_PVRL2_chr19_45368527_ENST00000252485_length(transcript)=1944nt_BP=271nt
GATCTAGTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCCAGCCTCCAGCAGCA
TGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGAGAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCC
CCCCAGCCCCAAACTCACCACCTGGCCGTGGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACT
GGAGCCCAGGATGTGCGAGTTCAAGTGCTACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCT
GTTCCTGGACTGTACATCTCCCTGGTGACCTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATG
GGTCCCAGCTTCCCCAGCCCGAAGCCTGGCAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAG
CTCCAGGACGCCACGCTGGCCCTCCACGGGCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCC
GTCCGAGGGATGACCTGGCTCAGAGTCATAGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACA
GTGGCCCTCTGCATCTCCAAAGAGGGCCGCCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTG
TCAGGGACCCTGGCCGGAACTGTCACTGTCACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAA
GTGGAGCATGAGAGCTTCGAGGAACCAGCCCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGAT
GACAACTGGTACCTCGGCCGTACTGATGCCACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACC
TCAGGCACCTTCCCGACCTCCGCAGTGGCCCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGC
ACAGTCACCAATGCCGTGGGCATGGGCCGCGCTGAGCAGGTCATCTTTGTCCGAGAAACCCCCAGGGCCTCGCCCCGAGATGTGGGCCCG
CTGGTGTGGGGGGCCGTGGGGGGGACACTGCTGGTGCTGCTGCTTCTGGCTGGGGGGTCCTTGGCCTTCATCCTGCTGAGGGTGAGGAGG
AGGAGGAAGAGCCCTGGAGGAGCAGGAGGAGGAGCCAGTGGCGACGGGGGATTCTACGATCCGAAAGCTCAGGTGTTGGGAAATGGGGAC
CCCGTCTTCTGGACACCAGTAGTCCCTGGTCCCATGGAACCAGATGGCAAGGATGAGGAGGAGGAGGAGGAGGAAGAGAAGGCAGAGAAA
GGCCTCATGTTGCCTCCACCCCCAGCACTCGAGGATGACATGGAGTCCCAGCTGGACGGCTCCCTCATCTCACGGCGGGCAGTTTATGTG
TGACCTGGACACAGACAGAGACAGAGCCAGGCCCGGCCCTCCCGCCCCCGACCTGACCACGCCGGCCTAGGGTTCCAGACTGGTTGGACT
TGTTCGTCTGGACGACACTGGAGTGGAACACTGCCTCCCACTTTCTTGGGACTTGGAGGGAGGTGGAACAGCACACTGGACTTCTCCCGT
CTCTAGGGCTGCATGGGGAGCCCGGGGAGCTGAGTAGTGGGGATCCAGAGAGGACCCCCGCCCCCAGAGACTTGGTTTTGGCTCCAGCCT

>43067_43067_2_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000325321_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=531AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAG

--------------------------------------------------------------
>43067_43067_3_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000358049_PVRL2_chr19_45368527_ENST00000252483_length(transcript)=2440nt_BP=62nt
GGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGAGCCCAGGATGTGCGAGTTCAAGTGCT
ACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCTGTTCCTGGACTGTACATCTCCCTGGTGAC
CTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATGGGTCCCAGCTTCCCCAGCCCGAAGCCTGG
CAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAGCTCCAGGACGCCACGCTGGCCCTCCACGG
GCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCCGTCCGAGGGATGACCTGGCTCAGAGTCAT
AGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACAGTGGCCCTCTGCATCTCCAAAGAGGGCCG
CCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTGTCAGGGACCCTGGCCGGAACTGTCACTGT
CACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAAGTGGAGCATGAGAGCTTCGAGGAACCAGC
CCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGATGACAACTGGTACCTCGGCCGTACTGATGC
CACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACCTCAGGCACCTTCCCGACCTCCGCAGTGGC
CCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGCACAGTCACCAATGCCGTGGGCATGGGCCG
CGCTGAGCAGGTCATCTTTGTCCGAGAGACCCCCAACACAGCAGGCGCAGGGGCCACAGGCGGCATCATCGGGGGCATCATCGCCGCCAT
CATTGCTACTGCTGTGGCTGCCACGGGCATCCTTATCTGCCGGCAGCAGCGGAAGGAGCAGACGCTGCAGGGGGCAGAGGAGGACGAAGA
CCTGGAGGGACCTCCCTCCTACAAGCCACCAACCCCAAAAGCGAAGCTGGAGGCACAGGAGATGCCCTCCCAGCTCTTCACTCTGGGGGC
CTCGGAGCACAGCCCACTCAAGACCCCCTACTTTGATGCTGGCGCCTCATGCACTGAGCAGGAAATGCCTCGATACCATGAGCTGCCCAC
CTTGGAAGAACGGTCAGGACCCTTGCACCCTGGAGCCACAAGCCTGGGGTCCCCCATCCCGGTGCCTCCAGGGCCACCTGCTGTGGAAGA
CGTTTCCCTGGATCTAGAGGATGAGGAGGGGGAGGAGGAGGAAGAGTATCTGGACAAGATCAACCCCATCTATGATGCTCTGTCCTATAG
CAGCCCCTCTGATTCCTACCAGGGCAAAGGCTTTGTCATGTCCCGGGCCATGTATGTGTGAGCTGCCATGCGCCTGGCGTCTCACATCTC
ACCTGTTGATCCCTTAGCTTTCTTGCCAAGGATCTAGTGCCCCCTGACCTCTGGCCAGGCCACTGTCAGTTAACACATATGCATTCCATT
TGTGATGTCTACCTTGGTGGCTCCACTATGACCCCTAACCCATGAGCCCAGAGAAATTCACCGTGATAATGGAATCCTGGCAACCTTATC
TCATGAGGCAGGAGGTGGGGAAGGTGCTTCTGCACAACCTCTGATCCCAAGGACTCCTCTCCCAGACTGTGACCTTAGACCATACCTCTC
ACCCCCCAATGCCTCGACTCCCCCAAAATCACAAAGAAGACCCTAGACCTATAATTTGTCTTCAGGTAGTAAATTCCCAATAGGTCTGCT
GGAGTGGGCGCTGAGGGCTCCCTGCTGCTCAGACCTGAGCCCTCCAGGCAGCAGGGTCCCACTTACCCCCTCCCCACCCTGTTCCCCAAA
GGTGGGAAAGAGGGGATTCCCCAGCCCAAGGCAGGGTTTTCCCAGCACCCTCCTGTAAGCAGAAGTCTCAGGGTCCAGACCCTTCCCTGA
GCCCCCACCCCCACCCCAATTCCTGCCTACCAAGCAAGCAGCCCCAGCCTAGGGTCAGACAGGGTGAGCCTCATACAGACTGTGCCTTGA
TGGCCCCAGCCTTGGGAGAAGAATTTACTGTTAACCTGGAAGACTACTGAATCATTTTACCCTTGCCCAGTGGAATAGGACCTAAACATC
CCCCTTCCGGGGAAAGTGGGTCATCTGAATTGGGGGTAGCAATTGATACTGTTTTGTAAACTACATTTCCTACAAAATATGAATTTATAC

>43067_43067_3_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000358049_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=524AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAV
AATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERS

--------------------------------------------------------------
>43067_43067_4_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000358049_PVRL2_chr19_45368527_ENST00000252485_length(transcript)=1735nt_BP=62nt
GGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGAGCCCAGGATGTGCGAGTTCAAGTGCT
ACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCTGTTCCTGGACTGTACATCTCCCTGGTGAC
CTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATGGGTCCCAGCTTCCCCAGCCCGAAGCCTGG
CAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAGCTCCAGGACGCCACGCTGGCCCTCCACGG
GCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCCGTCCGAGGGATGACCTGGCTCAGAGTCAT
AGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACAGTGGCCCTCTGCATCTCCAAAGAGGGCCG
CCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTGTCAGGGACCCTGGCCGGAACTGTCACTGT
CACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAAGTGGAGCATGAGAGCTTCGAGGAACCAGC
CCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGATGACAACTGGTACCTCGGCCGTACTGATGC
CACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACCTCAGGCACCTTCCCGACCTCCGCAGTGGC
CCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGCACAGTCACCAATGCCGTGGGCATGGGCCG
CGCTGAGCAGGTCATCTTTGTCCGAGAAACCCCCAGGGCCTCGCCCCGAGATGTGGGCCCGCTGGTGTGGGGGGCCGTGGGGGGGACACT
GCTGGTGCTGCTGCTTCTGGCTGGGGGGTCCTTGGCCTTCATCCTGCTGAGGGTGAGGAGGAGGAGGAAGAGCCCTGGAGGAGCAGGAGG
AGGAGCCAGTGGCGACGGGGGATTCTACGATCCGAAAGCTCAGGTGTTGGGAAATGGGGACCCCGTCTTCTGGACACCAGTAGTCCCTGG
TCCCATGGAACCAGATGGCAAGGATGAGGAGGAGGAGGAGGAGGAAGAGAAGGCAGAGAAAGGCCTCATGTTGCCTCCACCCCCAGCACT
CGAGGATGACATGGAGTCCCAGCTGGACGGCTCCCTCATCTCACGGCGGGCAGTTTATGTGTGACCTGGACACAGACAGAGACAGAGCCA
GGCCCGGCCCTCCCGCCCCCGACCTGACCACGCCGGCCTAGGGTTCCAGACTGGTTGGACTTGTTCGTCTGGACGACACTGGAGTGGAAC
ACTGCCTCCCACTTTCTTGGGACTTGGAGGGAGGTGGAACAGCACACTGGACTTCTCCCGTCTCTAGGGCTGCATGGGGAGCCCGGGGAG
CTGAGTAGTGGGGATCCAGAGAGGACCCCCGCCCCCAGAGACTTGGTTTTGGCTCCAGCCTTCCCCTGGCCCCGTGACACTCAGGAGTTA

>43067_43067_4_KLK2-PVRL2_KLK2_chr19_51376774_ENST00000358049_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=465AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLL
LAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDME

--------------------------------------------------------------
>43067_43067_5_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368527_ENST00000252483_length(transcript)=2649nt_BP=271nt
GATCTAGTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCCAGCCTCCAGCAGCA
TGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGAGAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCC
CCCCAGCCCCAAACTCACCACCTGGCCGTGGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACT
GGAGCCCAGGATGTGCGAGTTCAAGTGCTACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCT
GTTCCTGGACTGTACATCTCCCTGGTGACCTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATG
GGTCCCAGCTTCCCCAGCCCGAAGCCTGGCAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAG
CTCCAGGACGCCACGCTGGCCCTCCACGGGCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCC
GTCCGAGGGATGACCTGGCTCAGAGTCATAGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACA
GTGGCCCTCTGCATCTCCAAAGAGGGCCGCCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTG
TCAGGGACCCTGGCCGGAACTGTCACTGTCACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAA
GTGGAGCATGAGAGCTTCGAGGAACCAGCCCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGAT
GACAACTGGTACCTCGGCCGTACTGATGCCACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACC
TCAGGCACCTTCCCGACCTCCGCAGTGGCCCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGC
ACAGTCACCAATGCCGTGGGCATGGGCCGCGCTGAGCAGGTCATCTTTGTCCGAGAGACCCCCAACACAGCAGGCGCAGGGGCCACAGGC
GGCATCATCGGGGGCATCATCGCCGCCATCATTGCTACTGCTGTGGCTGCCACGGGCATCCTTATCTGCCGGCAGCAGCGGAAGGAGCAG
ACGCTGCAGGGGGCAGAGGAGGACGAAGACCTGGAGGGACCTCCCTCCTACAAGCCACCAACCCCAAAAGCGAAGCTGGAGGCACAGGAG
ATGCCCTCCCAGCTCTTCACTCTGGGGGCCTCGGAGCACAGCCCACTCAAGACCCCCTACTTTGATGCTGGCGCCTCATGCACTGAGCAG
GAAATGCCTCGATACCATGAGCTGCCCACCTTGGAAGAACGGTCAGGACCCTTGCACCCTGGAGCCACAAGCCTGGGGTCCCCCATCCCG
GTGCCTCCAGGGCCACCTGCTGTGGAAGACGTTTCCCTGGATCTAGAGGATGAGGAGGGGGAGGAGGAGGAAGAGTATCTGGACAAGATC
AACCCCATCTATGATGCTCTGTCCTATAGCAGCCCCTCTGATTCCTACCAGGGCAAAGGCTTTGTCATGTCCCGGGCCATGTATGTGTGA
GCTGCCATGCGCCTGGCGTCTCACATCTCACCTGTTGATCCCTTAGCTTTCTTGCCAAGGATCTAGTGCCCCCTGACCTCTGGCCAGGCC
ACTGTCAGTTAACACATATGCATTCCATTTGTGATGTCTACCTTGGTGGCTCCACTATGACCCCTAACCCATGAGCCCAGAGAAATTCAC
CGTGATAATGGAATCCTGGCAACCTTATCTCATGAGGCAGGAGGTGGGGAAGGTGCTTCTGCACAACCTCTGATCCCAAGGACTCCTCTC
CCAGACTGTGACCTTAGACCATACCTCTCACCCCCCAATGCCTCGACTCCCCCAAAATCACAAAGAAGACCCTAGACCTATAATTTGTCT
TCAGGTAGTAAATTCCCAATAGGTCTGCTGGAGTGGGCGCTGAGGGCTCCCTGCTGCTCAGACCTGAGCCCTCCAGGCAGCAGGGTCCCA
CTTACCCCCTCCCCACCCTGTTCCCCAAAGGTGGGAAAGAGGGGATTCCCCAGCCCAAGGCAGGGTTTTCCCAGCACCCTCCTGTAAGCA
GAAGTCTCAGGGTCCAGACCCTTCCCTGAGCCCCCACCCCCACCCCAATTCCTGCCTACCAAGCAAGCAGCCCCAGCCTAGGGTCAGACA
GGGTGAGCCTCATACAGACTGTGCCTTGATGGCCCCAGCCTTGGGAGAAGAATTTACTGTTAACCTGGAAGACTACTGAATCATTTTACC
CTTGCCCAGTGGAATAGGACCTAAACATCCCCCTTCCGGGGAAAGTGGGTCATCTGAATTGGGGGTAGCAATTGATACTGTTTTGTAAAC

>43067_43067_5_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=590AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDE
DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVE

--------------------------------------------------------------
>43067_43067_6_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368527_ENST00000252485_length(transcript)=1944nt_BP=271nt
GATCTAGTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCCAGCCTCCAGCAGCA
TGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGAGAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCC
CCCCAGCCCCAAACTCACCACCTGGCCGTGGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACT
GGAGCCCAGGATGTGCGAGTTCAAGTGCTACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCT
GTTCCTGGACTGTACATCTCCCTGGTGACCTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATG
GGTCCCAGCTTCCCCAGCCCGAAGCCTGGCAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAG
CTCCAGGACGCCACGCTGGCCCTCCACGGGCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCC
GTCCGAGGGATGACCTGGCTCAGAGTCATAGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACA
GTGGCCCTCTGCATCTCCAAAGAGGGCCGCCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTG
TCAGGGACCCTGGCCGGAACTGTCACTGTCACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAA
GTGGAGCATGAGAGCTTCGAGGAACCAGCCCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGAT
GACAACTGGTACCTCGGCCGTACTGATGCCACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACC
TCAGGCACCTTCCCGACCTCCGCAGTGGCCCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGC
ACAGTCACCAATGCCGTGGGCATGGGCCGCGCTGAGCAGGTCATCTTTGTCCGAGAAACCCCCAGGGCCTCGCCCCGAGATGTGGGCCCG
CTGGTGTGGGGGGCCGTGGGGGGGACACTGCTGGTGCTGCTGCTTCTGGCTGGGGGGTCCTTGGCCTTCATCCTGCTGAGGGTGAGGAGG
AGGAGGAAGAGCCCTGGAGGAGCAGGAGGAGGAGCCAGTGGCGACGGGGGATTCTACGATCCGAAAGCTCAGGTGTTGGGAAATGGGGAC
CCCGTCTTCTGGACACCAGTAGTCCCTGGTCCCATGGAACCAGATGGCAAGGATGAGGAGGAGGAGGAGGAGGAAGAGAAGGCAGAGAAA
GGCCTCATGTTGCCTCCACCCCCAGCACTCGAGGATGACATGGAGTCCCAGCTGGACGGCTCCCTCATCTCACGGCGGGCAGTTTATGTG
TGACCTGGACACAGACAGAGACAGAGCCAGGCCCGGCCCTCCCGCCCCCGACCTGACCACGCCGGCCTAGGGTTCCAGACTGGTTGGACT
TGTTCGTCTGGACGACACTGGAGTGGAACACTGCCTCCCACTTTCTTGGGACTTGGAGGGAGGTGGAACAGCACACTGGACTTCTCCCGT
CTCTAGGGCTGCATGGGGAGCCCGGGGAGCTGAGTAGTGGGGATCCAGAGAGGACCCCCGCCCCCAGAGACTTGGTTTTGGCTCCAGCCT

>43067_43067_6_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=531AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAG

--------------------------------------------------------------
>43067_43067_7_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368528_ENST00000252483_length(transcript)=2649nt_BP=271nt
GATCTAGTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCCAGCCTCCAGCAGCA
TGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGAGAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCC
CCCCAGCCCCAAACTCACCACCTGGCCGTGGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACT
GGAGCCCAGGATGTGCGAGTTCAAGTGCTACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCT
GTTCCTGGACTGTACATCTCCCTGGTGACCTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATG
GGTCCCAGCTTCCCCAGCCCGAAGCCTGGCAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAG
CTCCAGGACGCCACGCTGGCCCTCCACGGGCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCC
GTCCGAGGGATGACCTGGCTCAGAGTCATAGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACA
GTGGCCCTCTGCATCTCCAAAGAGGGCCGCCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTG
TCAGGGACCCTGGCCGGAACTGTCACTGTCACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAA
GTGGAGCATGAGAGCTTCGAGGAACCAGCCCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGAT
GACAACTGGTACCTCGGCCGTACTGATGCCACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACC
TCAGGCACCTTCCCGACCTCCGCAGTGGCCCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGC
ACAGTCACCAATGCCGTGGGCATGGGCCGCGCTGAGCAGGTCATCTTTGTCCGAGAGACCCCCAACACAGCAGGCGCAGGGGCCACAGGC
GGCATCATCGGGGGCATCATCGCCGCCATCATTGCTACTGCTGTGGCTGCCACGGGCATCCTTATCTGCCGGCAGCAGCGGAAGGAGCAG
ACGCTGCAGGGGGCAGAGGAGGACGAAGACCTGGAGGGACCTCCCTCCTACAAGCCACCAACCCCAAAAGCGAAGCTGGAGGCACAGGAG
ATGCCCTCCCAGCTCTTCACTCTGGGGGCCTCGGAGCACAGCCCACTCAAGACCCCCTACTTTGATGCTGGCGCCTCATGCACTGAGCAG
GAAATGCCTCGATACCATGAGCTGCCCACCTTGGAAGAACGGTCAGGACCCTTGCACCCTGGAGCCACAAGCCTGGGGTCCCCCATCCCG
GTGCCTCCAGGGCCACCTGCTGTGGAAGACGTTTCCCTGGATCTAGAGGATGAGGAGGGGGAGGAGGAGGAAGAGTATCTGGACAAGATC
AACCCCATCTATGATGCTCTGTCCTATAGCAGCCCCTCTGATTCCTACCAGGGCAAAGGCTTTGTCATGTCCCGGGCCATGTATGTGTGA
GCTGCCATGCGCCTGGCGTCTCACATCTCACCTGTTGATCCCTTAGCTTTCTTGCCAAGGATCTAGTGCCCCCTGACCTCTGGCCAGGCC
ACTGTCAGTTAACACATATGCATTCCATTTGTGATGTCTACCTTGGTGGCTCCACTATGACCCCTAACCCATGAGCCCAGAGAAATTCAC
CGTGATAATGGAATCCTGGCAACCTTATCTCATGAGGCAGGAGGTGGGGAAGGTGCTTCTGCACAACCTCTGATCCCAAGGACTCCTCTC
CCAGACTGTGACCTTAGACCATACCTCTCACCCCCCAATGCCTCGACTCCCCCAAAATCACAAAGAAGACCCTAGACCTATAATTTGTCT
TCAGGTAGTAAATTCCCAATAGGTCTGCTGGAGTGGGCGCTGAGGGCTCCCTGCTGCTCAGACCTGAGCCCTCCAGGCAGCAGGGTCCCA
CTTACCCCCTCCCCACCCTGTTCCCCAAAGGTGGGAAAGAGGGGATTCCCCAGCCCAAGGCAGGGTTTTCCCAGCACCCTCCTGTAAGCA
GAAGTCTCAGGGTCCAGACCCTTCCCTGAGCCCCCACCCCCACCCCAATTCCTGCCTACCAAGCAAGCAGCCCCAGCCTAGGGTCAGACA
GGGTGAGCCTCATACAGACTGTGCCTTGATGGCCCCAGCCTTGGGAGAAGAATTTACTGTTAACCTGGAAGACTACTGAATCATTTTACC
CTTGCCCAGTGGAATAGGACCTAAACATCCCCCTTCCGGGGAAAGTGGGTCATCTGAATTGGGGGTAGCAATTGATACTGTTTTGTAAAC

>43067_43067_7_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368528_ENST00000252483_length(amino acids)=590AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDE
DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVE

--------------------------------------------------------------
>43067_43067_8_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368528_ENST00000252485_length(transcript)=1944nt_BP=271nt
GATCTAGTATGTGTGGAACAGCAAGTGCTGGCTCTCCCTCCCCTTCCACAGCTCTGGGTGTGGGAGGGGGTTGTCCAGCCTCCAGCAGCA
TGGGGAGGGCCTTGGTCAGCATCTAGGTGCCAACAGGGCAAGGGCGGGGTCCTGGAGAATGAAGGCTTTATAGGGCTCCTCAGGGAGGCC
CCCCAGCCCCAAACTCACCACCTGGCCGTGGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACT
GGAGCCCAGGATGTGCGAGTTCAAGTGCTACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCT
GTTCCTGGACTGTACATCTCCCTGGTGACCTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATG
GGTCCCAGCTTCCCCAGCCCGAAGCCTGGCAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAG
CTCCAGGACGCCACGCTGGCCCTCCACGGGCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCC
GTCCGAGGGATGACCTGGCTCAGAGTCATAGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACA
GTGGCCCTCTGCATCTCCAAAGAGGGCCGCCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTG
TCAGGGACCCTGGCCGGAACTGTCACTGTCACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAA
GTGGAGCATGAGAGCTTCGAGGAACCAGCCCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGAT
GACAACTGGTACCTCGGCCGTACTGATGCCACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACC
TCAGGCACCTTCCCGACCTCCGCAGTGGCCCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGC
ACAGTCACCAATGCCGTGGGCATGGGCCGCGCTGAGCAGGTCATCTTTGTCCGAGAAACCCCCAGGGCCTCGCCCCGAGATGTGGGCCCG
CTGGTGTGGGGGGCCGTGGGGGGGACACTGCTGGTGCTGCTGCTTCTGGCTGGGGGGTCCTTGGCCTTCATCCTGCTGAGGGTGAGGAGG
AGGAGGAAGAGCCCTGGAGGAGCAGGAGGAGGAGCCAGTGGCGACGGGGGATTCTACGATCCGAAAGCTCAGGTGTTGGGAAATGGGGAC
CCCGTCTTCTGGACACCAGTAGTCCCTGGTCCCATGGAACCAGATGGCAAGGATGAGGAGGAGGAGGAGGAGGAAGAGAAGGCAGAGAAA
GGCCTCATGTTGCCTCCACCCCCAGCACTCGAGGATGACATGGAGTCCCAGCTGGACGGCTCCCTCATCTCACGGCGGGCAGTTTATGTG
TGACCTGGACACAGACAGAGACAGAGCCAGGCCCGGCCCTCCCGCCCCCGACCTGACCACGCCGGCCTAGGGTTCCAGACTGGTTGGACT
TGTTCGTCTGGACGACACTGGAGTGGAACACTGCCTCCCACTTTCTTGGGACTTGGAGGGAGGTGGAACAGCACACTGGACTTCTCCCGT
CTCTAGGGCTGCATGGGGAGCCCGGGGAGCTGAGTAGTGGGGATCCAGAGAGGACCCCCGCCCCCAGAGACTTGGTTTTGGCTCCAGCCT

>43067_43067_8_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000325321_PVRL2_chr19_45368528_ENST00000252485_length(amino acids)=531AA_BP=79
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAQDVRVQV
LPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALH
GLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVT
VTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAV
AQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAG

--------------------------------------------------------------
>43067_43067_9_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368527_ENST00000252483_length(transcript)=2440nt_BP=62nt
GGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGAGCCCAGGATGTGCGAGTTCAAGTGCT
ACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCTGTTCCTGGACTGTACATCTCCCTGGTGAC
CTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATGGGTCCCAGCTTCCCCAGCCCGAAGCCTGG
CAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAGCTCCAGGACGCCACGCTGGCCCTCCACGG
GCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCCGTCCGAGGGATGACCTGGCTCAGAGTCAT
AGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACAGTGGCCCTCTGCATCTCCAAAGAGGGCCG
CCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTGTCAGGGACCCTGGCCGGAACTGTCACTGT
CACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAAGTGGAGCATGAGAGCTTCGAGGAACCAGC
CCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGATGACAACTGGTACCTCGGCCGTACTGATGC
CACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACCTCAGGCACCTTCCCGACCTCCGCAGTGGC
CCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGCACAGTCACCAATGCCGTGGGCATGGGCCG
CGCTGAGCAGGTCATCTTTGTCCGAGAGACCCCCAACACAGCAGGCGCAGGGGCCACAGGCGGCATCATCGGGGGCATCATCGCCGCCAT
CATTGCTACTGCTGTGGCTGCCACGGGCATCCTTATCTGCCGGCAGCAGCGGAAGGAGCAGACGCTGCAGGGGGCAGAGGAGGACGAAGA
CCTGGAGGGACCTCCCTCCTACAAGCCACCAACCCCAAAAGCGAAGCTGGAGGCACAGGAGATGCCCTCCCAGCTCTTCACTCTGGGGGC
CTCGGAGCACAGCCCACTCAAGACCCCCTACTTTGATGCTGGCGCCTCATGCACTGAGCAGGAAATGCCTCGATACCATGAGCTGCCCAC
CTTGGAAGAACGGTCAGGACCCTTGCACCCTGGAGCCACAAGCCTGGGGTCCCCCATCCCGGTGCCTCCAGGGCCACCTGCTGTGGAAGA
CGTTTCCCTGGATCTAGAGGATGAGGAGGGGGAGGAGGAGGAAGAGTATCTGGACAAGATCAACCCCATCTATGATGCTCTGTCCTATAG
CAGCCCCTCTGATTCCTACCAGGGCAAAGGCTTTGTCATGTCCCGGGCCATGTATGTGTGAGCTGCCATGCGCCTGGCGTCTCACATCTC
ACCTGTTGATCCCTTAGCTTTCTTGCCAAGGATCTAGTGCCCCCTGACCTCTGGCCAGGCCACTGTCAGTTAACACATATGCATTCCATT
TGTGATGTCTACCTTGGTGGCTCCACTATGACCCCTAACCCATGAGCCCAGAGAAATTCACCGTGATAATGGAATCCTGGCAACCTTATC
TCATGAGGCAGGAGGTGGGGAAGGTGCTTCTGCACAACCTCTGATCCCAAGGACTCCTCTCCCAGACTGTGACCTTAGACCATACCTCTC
ACCCCCCAATGCCTCGACTCCCCCAAAATCACAAAGAAGACCCTAGACCTATAATTTGTCTTCAGGTAGTAAATTCCCAATAGGTCTGCT
GGAGTGGGCGCTGAGGGCTCCCTGCTGCTCAGACCTGAGCCCTCCAGGCAGCAGGGTCCCACTTACCCCCTCCCCACCCTGTTCCCCAAA
GGTGGGAAAGAGGGGATTCCCCAGCCCAAGGCAGGGTTTTCCCAGCACCCTCCTGTAAGCAGAAGTCTCAGGGTCCAGACCCTTCCCTGA
GCCCCCACCCCCACCCCAATTCCTGCCTACCAAGCAAGCAGCCCCAGCCTAGGGTCAGACAGGGTGAGCCTCATACAGACTGTGCCTTGA
TGGCCCCAGCCTTGGGAGAAGAATTTACTGTTAACCTGGAAGACTACTGAATCATTTTACCCTTGCCCAGTGGAATAGGACCTAAACATC
CCCCTTCCGGGGAAAGTGGGTCATCTGAATTGGGGGTAGCAATTGATACTGTTTTGTAAACTACATTTCCTACAAAATATGAATTTATAC

>43067_43067_9_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368527_ENST00000252483_length(amino acids)=524AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAV
AATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERS

--------------------------------------------------------------
>43067_43067_10_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368527_ENST00000252485_length(transcript)=1735nt_BP=62nt
GGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGAGCCCAGGATGTGCGAGTTCAAGTGCT
ACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCTGTTCCTGGACTGTACATCTCCCTGGTGAC
CTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATGGGTCCCAGCTTCCCCAGCCCGAAGCCTGG
CAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAGCTCCAGGACGCCACGCTGGCCCTCCACGG
GCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCCGTCCGAGGGATGACCTGGCTCAGAGTCAT
AGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACAGTGGCCCTCTGCATCTCCAAAGAGGGCCG
CCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTGTCAGGGACCCTGGCCGGAACTGTCACTGT
CACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAAGTGGAGCATGAGAGCTTCGAGGAACCAGC
CCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGATGACAACTGGTACCTCGGCCGTACTGATGC
CACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACCTCAGGCACCTTCCCGACCTCCGCAGTGGC
CCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGCACAGTCACCAATGCCGTGGGCATGGGCCG
CGCTGAGCAGGTCATCTTTGTCCGAGAAACCCCCAGGGCCTCGCCCCGAGATGTGGGCCCGCTGGTGTGGGGGGCCGTGGGGGGGACACT
GCTGGTGCTGCTGCTTCTGGCTGGGGGGTCCTTGGCCTTCATCCTGCTGAGGGTGAGGAGGAGGAGGAAGAGCCCTGGAGGAGCAGGAGG
AGGAGCCAGTGGCGACGGGGGATTCTACGATCCGAAAGCTCAGGTGTTGGGAAATGGGGACCCCGTCTTCTGGACACCAGTAGTCCCTGG
TCCCATGGAACCAGATGGCAAGGATGAGGAGGAGGAGGAGGAGGAAGAGAAGGCAGAGAAAGGCCTCATGTTGCCTCCACCCCCAGCACT
CGAGGATGACATGGAGTCCCAGCTGGACGGCTCCCTCATCTCACGGCGGGCAGTTTATGTGTGACCTGGACACAGACAGAGACAGAGCCA
GGCCCGGCCCTCCCGCCCCCGACCTGACCACGCCGGCCTAGGGTTCCAGACTGGTTGGACTTGTTCGTCTGGACGACACTGGAGTGGAAC
ACTGCCTCCCACTTTCTTGGGACTTGGAGGGAGGTGGAACAGCACACTGGACTTCTCCCGTCTCTAGGGCTGCATGGGGAGCCCGGGGAG
CTGAGTAGTGGGGATCCAGAGAGGACCCCCGCCCCCAGAGACTTGGTTTTGGCTCCAGCCTTCCCCTGGCCCCGTGACACTCAGGAGTTA

>43067_43067_10_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368527_ENST00000252485_length(amino acids)=465AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLL
LAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDME

--------------------------------------------------------------
>43067_43067_11_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368528_ENST00000252483_length(transcript)=2440nt_BP=62nt
GGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGAGCCCAGGATGTGCGAGTTCAAGTGCT
ACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCTGTTCCTGGACTGTACATCTCCCTGGTGAC
CTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATGGGTCCCAGCTTCCCCAGCCCGAAGCCTGG
CAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAGCTCCAGGACGCCACGCTGGCCCTCCACGG
GCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCCGTCCGAGGGATGACCTGGCTCAGAGTCAT
AGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACAGTGGCCCTCTGCATCTCCAAAGAGGGCCG
CCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTGTCAGGGACCCTGGCCGGAACTGTCACTGT
CACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAAGTGGAGCATGAGAGCTTCGAGGAACCAGC
CCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGATGACAACTGGTACCTCGGCCGTACTGATGC
CACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACCTCAGGCACCTTCCCGACCTCCGCAGTGGC
CCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGCACAGTCACCAATGCCGTGGGCATGGGCCG
CGCTGAGCAGGTCATCTTTGTCCGAGAGACCCCCAACACAGCAGGCGCAGGGGCCACAGGCGGCATCATCGGGGGCATCATCGCCGCCAT
CATTGCTACTGCTGTGGCTGCCACGGGCATCCTTATCTGCCGGCAGCAGCGGAAGGAGCAGACGCTGCAGGGGGCAGAGGAGGACGAAGA
CCTGGAGGGACCTCCCTCCTACAAGCCACCAACCCCAAAAGCGAAGCTGGAGGCACAGGAGATGCCCTCCCAGCTCTTCACTCTGGGGGC
CTCGGAGCACAGCCCACTCAAGACCCCCTACTTTGATGCTGGCGCCTCATGCACTGAGCAGGAAATGCCTCGATACCATGAGCTGCCCAC
CTTGGAAGAACGGTCAGGACCCTTGCACCCTGGAGCCACAAGCCTGGGGTCCCCCATCCCGGTGCCTCCAGGGCCACCTGCTGTGGAAGA
CGTTTCCCTGGATCTAGAGGATGAGGAGGGGGAGGAGGAGGAAGAGTATCTGGACAAGATCAACCCCATCTATGATGCTCTGTCCTATAG
CAGCCCCTCTGATTCCTACCAGGGCAAAGGCTTTGTCATGTCCCGGGCCATGTATGTGTGAGCTGCCATGCGCCTGGCGTCTCACATCTC
ACCTGTTGATCCCTTAGCTTTCTTGCCAAGGATCTAGTGCCCCCTGACCTCTGGCCAGGCCACTGTCAGTTAACACATATGCATTCCATT
TGTGATGTCTACCTTGGTGGCTCCACTATGACCCCTAACCCATGAGCCCAGAGAAATTCACCGTGATAATGGAATCCTGGCAACCTTATC
TCATGAGGCAGGAGGTGGGGAAGGTGCTTCTGCACAACCTCTGATCCCAAGGACTCCTCTCCCAGACTGTGACCTTAGACCATACCTCTC
ACCCCCCAATGCCTCGACTCCCCCAAAATCACAAAGAAGACCCTAGACCTATAATTTGTCTTCAGGTAGTAAATTCCCAATAGGTCTGCT
GGAGTGGGCGCTGAGGGCTCCCTGCTGCTCAGACCTGAGCCCTCCAGGCAGCAGGGTCCCACTTACCCCCTCCCCACCCTGTTCCCCAAA
GGTGGGAAAGAGGGGATTCCCCAGCCCAAGGCAGGGTTTTCCCAGCACCCTCCTGTAAGCAGAAGTCTCAGGGTCCAGACCCTTCCCTGA
GCCCCCACCCCCACCCCAATTCCTGCCTACCAAGCAAGCAGCCCCAGCCTAGGGTCAGACAGGGTGAGCCTCATACAGACTGTGCCTTGA
TGGCCCCAGCCTTGGGAGAAGAATTTACTGTTAACCTGGAAGACTACTGAATCATTTTACCCTTGCCCAGTGGAATAGGACCTAAACATC
CCCCTTCCGGGGAAAGTGGGTCATCTGAATTGGGGGTAGCAATTGATACTGTTTTGTAAACTACATTTCCTACAAAATATGAATTTATAC

>43067_43067_11_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368528_ENST00000252483_length(amino acids)=524AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAV
AATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERS

--------------------------------------------------------------
>43067_43067_12_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368528_ENST00000252485_length(transcript)=1735nt_BP=62nt
GGACACCTGTGTCAGCATGTGGGACCTGGTTCTCTCCATCGCCTTGTCTGTGGGGTGCACTGGAGCCCAGGATGTGCGAGTTCAAGTGCT
ACCCGAGGTGCGAGGCCAGCTCGGGGGCACCGTGGAGCTGCCGTGCCACCTGCTGCCACCTGTTCCTGGACTGTACATCTCCCTGGTGAC
CTGGCAGCGCCCAGATGCACCTGCGAACCACCAGAATGTGGCCGCCTTCCACCCTAAGATGGGTCCCAGCTTCCCCAGCCCGAAGCCTGG
CAGCGAGCGGCTGTCCTTCGTCTCTGCCAAGCAGAGCACTGGGCAAGACACAGAGGCAGAGCTCCAGGACGCCACGCTGGCCCTCCACGG
GCTCACGGTGGAGGACGAGGGCAACTACACTTGCGAGTTTGCCACCTTCCCCAAGGGGTCCGTCCGAGGGATGACCTGGCTCAGAGTCAT
AGCCAAGCCCAAGAACCAAGCTGAGGCCCAGAAGGTCACGTTCAGCCAGGACCCTACGACAGTGGCCCTCTGCATCTCCAAAGAGGGCCG
CCCACCTGCCCGGATCTCCTGGCTCTCATCCCTGGACTGGGAAGCCAAAGAGACTCAGGTGTCAGGGACCCTGGCCGGAACTGTCACTGT
CACCAGCCGCTTCACCTTGGTGCCCTCGGGCCGAGCAGATGGTGTCACGGTCACCTGCAAAGTGGAGCATGAGAGCTTCGAGGAACCAGC
CCTGATACCTGTGACCCTCTCTGTACGCTACCCTCCTGAAGTGTCCATCTCCGGCTATGATGACAACTGGTACCTCGGCCGTACTGATGC
CACCCTGAGCTGTGACGTCCGCAGCAACCCAGAGCCCACGGGCTATGACTGGAGCACGACCTCAGGCACCTTCCCGACCTCCGCAGTGGC
CCAGGGCTCCCAGCTGGTCATCCACGCAGTGGACAGTCTGTTCAATACCACCTTCGTCTGCACAGTCACCAATGCCGTGGGCATGGGCCG
CGCTGAGCAGGTCATCTTTGTCCGAGAAACCCCCAGGGCCTCGCCCCGAGATGTGGGCCCGCTGGTGTGGGGGGCCGTGGGGGGGACACT
GCTGGTGCTGCTGCTTCTGGCTGGGGGGTCCTTGGCCTTCATCCTGCTGAGGGTGAGGAGGAGGAGGAAGAGCCCTGGAGGAGCAGGAGG
AGGAGCCAGTGGCGACGGGGGATTCTACGATCCGAAAGCTCAGGTGTTGGGAAATGGGGACCCCGTCTTCTGGACACCAGTAGTCCCTGG
TCCCATGGAACCAGATGGCAAGGATGAGGAGGAGGAGGAGGAGGAAGAGAAGGCAGAGAAAGGCCTCATGTTGCCTCCACCCCCAGCACT
CGAGGATGACATGGAGTCCCAGCTGGACGGCTCCCTCATCTCACGGCGGGCAGTTTATGTGTGACCTGGACACAGACAGAGACAGAGCCA
GGCCCGGCCCTCCCGCCCCCGACCTGACCACGCCGGCCTAGGGTTCCAGACTGGTTGGACTTGTTCGTCTGGACGACACTGGAGTGGAAC
ACTGCCTCCCACTTTCTTGGGACTTGGAGGGAGGTGGAACAGCACACTGGACTTCTCCCGTCTCTAGGGCTGCATGGGGAGCCCGGGGAG
CTGAGTAGTGGGGATCCAGAGAGGACCCCCGCCCCCAGAGACTTGGTTTTGGCTCCAGCCTTCCCCTGGCCCCGTGACACTCAGGAGTTA

>43067_43067_12_KLK2-PVRL2_KLK2_chr19_51376775_ENST00000358049_PVRL2_chr19_45368528_ENST00000252485_length(amino acids)=465AA_BP=13
MWDLVLSIALSVGCTGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLS
FVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARI
SWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCD
VRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLL
LAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDME

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KLK2-PVRL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLK2-PVRL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLK2-PVRL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource