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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLK3-CDC42EP4 (FusionGDB2 ID:43076)

Fusion Gene Summary for KLK3-CDC42EP4

check button Fusion gene summary
Fusion gene informationFusion gene name: KLK3-CDC42EP4
Fusion gene ID: 43076
HgeneTgene
Gene symbol

KLK3

CDC42EP4

Gene ID

3818

23580

Gene namekallikrein B1CDC42 effector protein 4
SynonymsKLK3|PKK|PKKD|PPKBORG4|CEP4|KAIA1777
Cytomap

4q35.2

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionplasma kallikreinkallikrein B, plasma (Fletcher factor) 1kininogeninplasma prekallikreincdc42 effector protein 4CDC42 effector protein (Rho GTPase binding) 4binder of Rho GTPases 4
Modification date2020032020200313
UniProtAcc

P07288

Q9H3Q1

Ensembl transtripts involved in fusion geneENST00000326003, ENST00000360617, 
ENST00000593997, ENST00000595952, 
ENST00000597483, 		ENST00000581014, 
ENST00000582303, ENST00000335793, 
ENST00000439510, 
Fusion gene scores* DoF score24 X 31 X 2=14887 X 3 X 6=126
# samples 3110
** MAII scorelog2(31/1488*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KLK3 [Title/Abstract] AND CDC42EP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLK3(51361401)-CDC42EP4(71282209), # samples:1
Anticipated loss of major functional domain due to fusion event.KLK3-CDC42EP4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLK3

GO:0031639

plasminogen activation

89876

HgeneKLK3

GO:0051919

positive regulation of fibrinolysis

89876

TgeneCDC42EP4

GO:0008360

regulation of cell shape

11035016

TgeneCDC42EP4

GO:0031274

positive regulation of pseudopodium assembly

11035016


check buttonFusion gene breakpoints across KLK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDC42EP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA874433KLK3chr19

51361401

+CDC42EP4chr17

71282209

-


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Fusion Gene ORF analysis for KLK3-CDC42EP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326003ENST00000581014KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
5CDS-intronENST00000326003ENST00000582303KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
5CDS-intronENST00000360617ENST00000581014KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
5CDS-intronENST00000360617ENST00000582303KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
5CDS-intronENST00000593997ENST00000581014KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
5CDS-intronENST00000593997ENST00000582303KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
Frame-shiftENST00000326003ENST00000335793KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
Frame-shiftENST00000360617ENST00000335793KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
Frame-shiftENST00000593997ENST00000335793KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
In-frameENST00000326003ENST00000439510KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
In-frameENST00000360617ENST00000439510KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
In-frameENST00000593997ENST00000439510KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-3CDSENST00000595952ENST00000335793KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-3CDSENST00000595952ENST00000439510KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-3CDSENST00000597483ENST00000335793KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-3CDSENST00000597483ENST00000439510KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-intronENST00000595952ENST00000581014KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-intronENST00000595952ENST00000582303KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-intronENST00000597483ENST00000581014KLK3chr19

51361401

+CDC42EP4chr17

71282209

-
intron-intronENST00000597483ENST00000582303KLK3chr19

51361401

+CDC42EP4chr17

71282209

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326003KLK3chr1951361401+ENST00000439510CDC42EP4chr1771282209-2863417171057346
ENST00000593997KLK3chr1951361401+ENST00000439510CDC42EP4chr1771282209-2843397211037338
ENST00000360617KLK3chr1951361401+ENST00000439510CDC42EP4chr1771282209-282237601016338

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326003ENST00000439510KLK3chr1951361401+CDC42EP4chr1771282209-0.0170973330.98290265
ENST00000593997ENST00000439510KLK3chr1951361401+CDC42EP4chr1771282209-0.017056370.98294365
ENST00000360617ENST00000439510KLK3chr1951361401+CDC42EP4chr1771282209-0.0164056940.98359436

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Fusion Genomic Features for KLK3-CDC42EP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLK3-CDC42EP4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51361401/chr17:71282209)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLK3

P07288

CDC42EP4

Q9H3Q1

FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.FUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDC42EP4chr19:51361401chr17:71282209ENST000003357930270_740357.0Compositional biasNote=Poly-Ser
TgeneCDC42EP4chr19:51361401chr17:71282209ENST000003357930227_410357.0DomainCRIB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLK3chr19:51361401chr17:71282209ENST00000326003+1525_2580262.0DomainPeptidase S1
HgeneKLK3chr19:51361401chr17:71282209ENST00000360617+1525_2580239.0DomainPeptidase S1
HgeneKLK3chr19:51361401chr17:71282209ENST00000593997+1425_2580228.0DomainPeptidase S1
HgeneKLK3chr19:51361401chr17:71282209ENST00000595952+1525_2580219.0DomainPeptidase S1


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Fusion Gene Sequence for KLK3-CDC42EP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43076_43076_1_KLK3-CDC42EP4_KLK3_chr19_51361401_ENST00000326003_CDC42EP4_chr17_71282209_ENST00000439510_length(transcript)=2863nt_BP=417nt
AGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTG
CTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCA
GGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAATCGATTCCTCAGGCCAGGTGATG
ACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGC
CAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTGAAGAAGGCCAATGACGGGGAGGGCGGCGATG
AGGAGGCGGGCACGGAGGAGGCAGTGCCCCGTCGGAATGGGGCCGCGGGTCCACATTCCCCTGACCCCCTCCTCGATGAGCAGGCCTTTG
GGGATCTGACAGATCTGCCTGTCGTGCCCAAGGCCACGTACGGGCTGAAGCATGCGGAGTCCATCATGTCCTTCCACATCGACCTGGGGC
CCTCCATGCTGGGTGACGTCCTCAGCATCATGGACAAGGAGGAGTGGGACCCCGAGGAGGGGGAGGGTGGTTACCATGGCGATGAGGGCG
CCGCTGGCACCATCACCCAGGCTCCCCCGTACGCCGTGGCGGCCCCTCCCCTGGCAAGGCAGGAAGGCAAGGCTGGCCCAGACTTGCCCT
CCCTCCCCTCCCATGCTCTGGAGGATGAGGGGTGGGCAGCAGCGGCCCCCAGCCCCGGCTCAGCCCGCAGCATGGGCAGCCACACCACAC
GGGACAGCAGCTCCCTCTCCAGCTGCACCTCAGGCATCCTGGAGGAGCGCAGCCCTGCCTTCCGGGGGCCGGACAGGGCCCGGGCTGCTG
TCTCAAGACAGCCAGACAAGGAGTTCTCCTTCATGGATGAGGAGGAGGAGGATGAAATCCGTGTGTGAGGCGGACAGTGGGTGGCCACCG
GGAGCTCTTGGCTGCATCTTCTCCCTGCCCCCACCCCACTATGACCTTTGACCCTACGGCGCAGGGGCAGCCAGGACCCTTGATTCAGAC
CATGGACCCTGGACCTTGTAGATGAGGGACACTGGCCTGGCCCTCGGGTCTTCGGAGGACGTAGGGGGCTGGCATGGGTGCCGACTGGCT
GCCTGACTTCATCATGCTCCCTGCACTTAGGCTGCGTGGGACAAGGGCTGTGTTGTCACAGCAGGAATAGGTTTTCCTCTGTTGGCCTCC
CTTTCCTCCACCCTGGCCTCAAATGGATGCCAGATGCCAACCCCAGTTCTGGCCACGTACAGCCAGCGGGTCAGCCCAGAGGCAGCCTCA
GCTCCAGGGCTAAGGACTCTCGGCTCCCATTTTCTCTGCTGGCGTTTCTGCTGTGCCCAGCAGTGGCTGCTGGGGAAGCAGCTGCAGCAG
GAGGGAGACGGTCTTGCCTCTCAGCCCCTCCCTGCCCCACCCCAGCTCCTGCCCTGGAAATCTGGAGCCCCTTGGAGCTGAGCTGGACGG
GGGGCCAGCTGCGAGCATGTGCACTAAACGCAGCCCTTTCCAGGGGAAGAGAACAGGATGGAGAATGGAAGGAAAGCCCCCCAGGCTTCG
TGAATTGCAAGAAGGGACCCTTCCAGGATGACACTAGGAACAGGGCTAGGGCACTCGCTCAGTCCCTAGGGGCTTGTTTGTTCTTTATTA
TTGTGTTTAAATCCTTATAGAGCAATATCAGGATGGTGTTAATAGGTCTGCCTCAGAATGAGAATCAATCCTTTTAGAAAACCTTTATAC
TAAGCCTCCTCTTCAAAATTCACAGTGGCGATTAGCGGACTGGAGTCTGGTGGCGATTAGCGGACTGGAGTCTGGGGACATCCGTGGCAA
AGACACCAGCTCAACTTTAGTGCTTCCCAACTTTATTTAGAATGACATGGGGTGGGTGTCTGGTGTGTGTGTTTTCCCTACGCACCTCCC
ATAGCTATTAACAACTGAGGAAGGCCAGTGCAGAATATTTTTGGAGAACGATTTTTTTTTTAAATAATATATCATTCCTATGGGGGGAAA
GCCTTTTTTTTCTTTTTGGCTGAGTTATTCCCTCCCTCCCCTCAATACCCTCAGTACTGACTACTTCCCTTTCTTTTCTCAGGCCTCCCC
CCACCGACTTTTGAGGCCAGGGTTGGCCAGATTTAGCAAAACCAAAACAGAGTGCTGAGTTAAACGCAAATTTCAGGTAAACAAAAGATA
ATTTTCTAGCATTAATATGCCCCACGCAATATTTGGAACACTTATGTGAAAAATGATTTGTTTTTCTGAAATTCACGTTTCTCTCTGAGT
CCTGTAACTGTCCCCGAGGGGATTGAGCAGAAGCTCGGGTATGAGCCCTGAGGTTGACTGCCGGTTATTTTTCTGTCCTGGGAACAGCCT
GACCCACCTCCCTGTCTCCATGTAGCCAGTGAGGGGAGGGGGAGACACAGAACCAACCACAGCCAGGGGCGTCCCCATGGCGACTGTGGC
CCGGCCCCTCCTCTCTTGCCTGACTCTCCTCTCTTGCCTGACTCTAGACACTAACTTAGTTCCAGGTTCGGTGCCCTGTTGGTGCTCCTG
TTTCCAATAGCTTAGGTCCCATGGTGGGGGAGGAACCTCAGGGGCTATGCAGCCCCCGCCAGCTGCCCTCGAATCCCGTCCAGGCCAATT

>43076_43076_1_KLK3-CDC42EP4_KLK3_chr19_51361401_ENST00000326003_CDC42EP4_chr17_71282209_ENST00000439510_length(amino acids)=346AA_BP=134
MHPESCVTMWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNRFLRPGDDSSHDL
MLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEELKKANDGEGGDEEAGTEEAVPRRNGAAGPHSPDPLLDEQAFGDLTDL
PVVPKATYGLKHAESIMSFHIDLGPSMLGDVLSIMDKEEWDPEEGEGGYHGDEGAAGTITQAPPYAVAAPPLARQEGKAGPDLPSLPSHA

--------------------------------------------------------------
>43076_43076_2_KLK3-CDC42EP4_KLK3_chr19_51361401_ENST00000360617_CDC42EP4_chr17_71282209_ENST00000439510_length(transcript)=2822nt_BP=376nt
ATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAG
TGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTC
CTCACAGCTGCCCACTGCATCAGGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCT
GCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGC
ATTGAACCAGAGGAGTTGAAGAAGGCCAATGACGGGGAGGGCGGCGATGAGGAGGCGGGCACGGAGGAGGCAGTGCCCCGTCGGAATGGG
GCCGCGGGTCCACATTCCCCTGACCCCCTCCTCGATGAGCAGGCCTTTGGGGATCTGACAGATCTGCCTGTCGTGCCCAAGGCCACGTAC
GGGCTGAAGCATGCGGAGTCCATCATGTCCTTCCACATCGACCTGGGGCCCTCCATGCTGGGTGACGTCCTCAGCATCATGGACAAGGAG
GAGTGGGACCCCGAGGAGGGGGAGGGTGGTTACCATGGCGATGAGGGCGCCGCTGGCACCATCACCCAGGCTCCCCCGTACGCCGTGGCG
GCCCCTCCCCTGGCAAGGCAGGAAGGCAAGGCTGGCCCAGACTTGCCCTCCCTCCCCTCCCATGCTCTGGAGGATGAGGGGTGGGCAGCA
GCGGCCCCCAGCCCCGGCTCAGCCCGCAGCATGGGCAGCCACACCACACGGGACAGCAGCTCCCTCTCCAGCTGCACCTCAGGCATCCTG
GAGGAGCGCAGCCCTGCCTTCCGGGGGCCGGACAGGGCCCGGGCTGCTGTCTCAAGACAGCCAGACAAGGAGTTCTCCTTCATGGATGAG
GAGGAGGAGGATGAAATCCGTGTGTGAGGCGGACAGTGGGTGGCCACCGGGAGCTCTTGGCTGCATCTTCTCCCTGCCCCCACCCCACTA
TGACCTTTGACCCTACGGCGCAGGGGCAGCCAGGACCCTTGATTCAGACCATGGACCCTGGACCTTGTAGATGAGGGACACTGGCCTGGC
CCTCGGGTCTTCGGAGGACGTAGGGGGCTGGCATGGGTGCCGACTGGCTGCCTGACTTCATCATGCTCCCTGCACTTAGGCTGCGTGGGA
CAAGGGCTGTGTTGTCACAGCAGGAATAGGTTTTCCTCTGTTGGCCTCCCTTTCCTCCACCCTGGCCTCAAATGGATGCCAGATGCCAAC
CCCAGTTCTGGCCACGTACAGCCAGCGGGTCAGCCCAGAGGCAGCCTCAGCTCCAGGGCTAAGGACTCTCGGCTCCCATTTTCTCTGCTG
GCGTTTCTGCTGTGCCCAGCAGTGGCTGCTGGGGAAGCAGCTGCAGCAGGAGGGAGACGGTCTTGCCTCTCAGCCCCTCCCTGCCCCACC
CCAGCTCCTGCCCTGGAAATCTGGAGCCCCTTGGAGCTGAGCTGGACGGGGGGCCAGCTGCGAGCATGTGCACTAAACGCAGCCCTTTCC
AGGGGAAGAGAACAGGATGGAGAATGGAAGGAAAGCCCCCCAGGCTTCGTGAATTGCAAGAAGGGACCCTTCCAGGATGACACTAGGAAC
AGGGCTAGGGCACTCGCTCAGTCCCTAGGGGCTTGTTTGTTCTTTATTATTGTGTTTAAATCCTTATAGAGCAATATCAGGATGGTGTTA
ATAGGTCTGCCTCAGAATGAGAATCAATCCTTTTAGAAAACCTTTATACTAAGCCTCCTCTTCAAAATTCACAGTGGCGATTAGCGGACT
GGAGTCTGGTGGCGATTAGCGGACTGGAGTCTGGGGACATCCGTGGCAAAGACACCAGCTCAACTTTAGTGCTTCCCAACTTTATTTAGA
ATGACATGGGGTGGGTGTCTGGTGTGTGTGTTTTCCCTACGCACCTCCCATAGCTATTAACAACTGAGGAAGGCCAGTGCAGAATATTTT
TGGAGAACGATTTTTTTTTTAAATAATATATCATTCCTATGGGGGGAAAGCCTTTTTTTTCTTTTTGGCTGAGTTATTCCCTCCCTCCCC
TCAATACCCTCAGTACTGACTACTTCCCTTTCTTTTCTCAGGCCTCCCCCCACCGACTTTTGAGGCCAGGGTTGGCCAGATTTAGCAAAA
CCAAAACAGAGTGCTGAGTTAAACGCAAATTTCAGGTAAACAAAAGATAATTTTCTAGCATTAATATGCCCCACGCAATATTTGGAACAC
TTATGTGAAAAATGATTTGTTTTTCTGAAATTCACGTTTCTCTCTGAGTCCTGTAACTGTCCCCGAGGGGATTGAGCAGAAGCTCGGGTA
TGAGCCCTGAGGTTGACTGCCGGTTATTTTTCTGTCCTGGGAACAGCCTGACCCACCTCCCTGTCTCCATGTAGCCAGTGAGGGGAGGGG
GAGACACAGAACCAACCACAGCCAGGGGCGTCCCCATGGCGACTGTGGCCCGGCCCCTCCTCTCTTGCCTGACTCTCCTCTCTTGCCTGA
CTCTAGACACTAACTTAGTTCCAGGTTCGGTGCCCTGTTGGTGCTCCTGTTTCCAATAGCTTAGGTCCCATGGTGGGGGAGGAACCTCAG
GGGCTATGCAGCCCCCGCCAGCTGCCCTCGAATCCCGTCCAGGCCAATTCCAGATTCTAAACTGATTTTTTTCATGATATTGTCAAAACA

>43076_43076_2_KLK3-CDC42EP4_KLK3_chr19_51361401_ENST00000360617_CDC42EP4_chr17_71282209_ENST00000439510_length(amino acids)=338AA_BP=126
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNRFLRPGDDSSHDLMLLRLSEP
AELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEELKKANDGEGGDEEAGTEEAVPRRNGAAGPHSPDPLLDEQAFGDLTDLPVVPKATY
GLKHAESIMSFHIDLGPSMLGDVLSIMDKEEWDPEEGEGGYHGDEGAAGTITQAPPYAVAAPPLARQEGKAGPDLPSLPSHALEDEGWAA

--------------------------------------------------------------
>43076_43076_3_KLK3-CDC42EP4_KLK3_chr19_51361401_ENST00000593997_CDC42EP4_chr17_71282209_ENST00000439510_length(transcript)=2843nt_BP=397nt
CACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCT
CGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTT
CTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATG
CTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGC
TACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTGAAGAAGGCCAATGACGGGGAGGGCGGCGATGAGGAGGCGGGCACGGAGGAG
GCAGTGCCCCGTCGGAATGGGGCCGCGGGTCCACATTCCCCTGACCCCCTCCTCGATGAGCAGGCCTTTGGGGATCTGACAGATCTGCCT
GTCGTGCCCAAGGCCACGTACGGGCTGAAGCATGCGGAGTCCATCATGTCCTTCCACATCGACCTGGGGCCCTCCATGCTGGGTGACGTC
CTCAGCATCATGGACAAGGAGGAGTGGGACCCCGAGGAGGGGGAGGGTGGTTACCATGGCGATGAGGGCGCCGCTGGCACCATCACCCAG
GCTCCCCCGTACGCCGTGGCGGCCCCTCCCCTGGCAAGGCAGGAAGGCAAGGCTGGCCCAGACTTGCCCTCCCTCCCCTCCCATGCTCTG
GAGGATGAGGGGTGGGCAGCAGCGGCCCCCAGCCCCGGCTCAGCCCGCAGCATGGGCAGCCACACCACACGGGACAGCAGCTCCCTCTCC
AGCTGCACCTCAGGCATCCTGGAGGAGCGCAGCCCTGCCTTCCGGGGGCCGGACAGGGCCCGGGCTGCTGTCTCAAGACAGCCAGACAAG
GAGTTCTCCTTCATGGATGAGGAGGAGGAGGATGAAATCCGTGTGTGAGGCGGACAGTGGGTGGCCACCGGGAGCTCTTGGCTGCATCTT
CTCCCTGCCCCCACCCCACTATGACCTTTGACCCTACGGCGCAGGGGCAGCCAGGACCCTTGATTCAGACCATGGACCCTGGACCTTGTA
GATGAGGGACACTGGCCTGGCCCTCGGGTCTTCGGAGGACGTAGGGGGCTGGCATGGGTGCCGACTGGCTGCCTGACTTCATCATGCTCC
CTGCACTTAGGCTGCGTGGGACAAGGGCTGTGTTGTCACAGCAGGAATAGGTTTTCCTCTGTTGGCCTCCCTTTCCTCCACCCTGGCCTC
AAATGGATGCCAGATGCCAACCCCAGTTCTGGCCACGTACAGCCAGCGGGTCAGCCCAGAGGCAGCCTCAGCTCCAGGGCTAAGGACTCT
CGGCTCCCATTTTCTCTGCTGGCGTTTCTGCTGTGCCCAGCAGTGGCTGCTGGGGAAGCAGCTGCAGCAGGAGGGAGACGGTCTTGCCTC
TCAGCCCCTCCCTGCCCCACCCCAGCTCCTGCCCTGGAAATCTGGAGCCCCTTGGAGCTGAGCTGGACGGGGGGCCAGCTGCGAGCATGT
GCACTAAACGCAGCCCTTTCCAGGGGAAGAGAACAGGATGGAGAATGGAAGGAAAGCCCCCCAGGCTTCGTGAATTGCAAGAAGGGACCC
TTCCAGGATGACACTAGGAACAGGGCTAGGGCACTCGCTCAGTCCCTAGGGGCTTGTTTGTTCTTTATTATTGTGTTTAAATCCTTATAG
AGCAATATCAGGATGGTGTTAATAGGTCTGCCTCAGAATGAGAATCAATCCTTTTAGAAAACCTTTATACTAAGCCTCCTCTTCAAAATT
CACAGTGGCGATTAGCGGACTGGAGTCTGGTGGCGATTAGCGGACTGGAGTCTGGGGACATCCGTGGCAAAGACACCAGCTCAACTTTAG
TGCTTCCCAACTTTATTTAGAATGACATGGGGTGGGTGTCTGGTGTGTGTGTTTTCCCTACGCACCTCCCATAGCTATTAACAACTGAGG
AAGGCCAGTGCAGAATATTTTTGGAGAACGATTTTTTTTTTAAATAATATATCATTCCTATGGGGGGAAAGCCTTTTTTTTCTTTTTGGC
TGAGTTATTCCCTCCCTCCCCTCAATACCCTCAGTACTGACTACTTCCCTTTCTTTTCTCAGGCCTCCCCCCACCGACTTTTGAGGCCAG
GGTTGGCCAGATTTAGCAAAACCAAAACAGAGTGCTGAGTTAAACGCAAATTTCAGGTAAACAAAAGATAATTTTCTAGCATTAATATGC
CCCACGCAATATTTGGAACACTTATGTGAAAAATGATTTGTTTTTCTGAAATTCACGTTTCTCTCTGAGTCCTGTAACTGTCCCCGAGGG
GATTGAGCAGAAGCTCGGGTATGAGCCCTGAGGTTGACTGCCGGTTATTTTTCTGTCCTGGGAACAGCCTGACCCACCTCCCTGTCTCCA
TGTAGCCAGTGAGGGGAGGGGGAGACACAGAACCAACCACAGCCAGGGGCGTCCCCATGGCGACTGTGGCCCGGCCCCTCCTCTCTTGCC
TGACTCTCCTCTCTTGCCTGACTCTAGACACTAACTTAGTTCCAGGTTCGGTGCCCTGTTGGTGCTCCTGTTTCCAATAGCTTAGGTCCC
ATGGTGGGGGAGGAACCTCAGGGGCTATGCAGCCCCCGCCAGCTGCCCTCGAATCCCGTCCAGGCCAATTCCAGATTCTAAACTGATTTT

>43076_43076_3_KLK3-CDC42EP4_KLK3_chr19_51361401_ENST00000593997_CDC42EP4_chr17_71282209_ENST00000439510_length(amino acids)=338AA_BP=126
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNRFLRPGDDSSHDLMLLRLSEP
AELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEELKKANDGEGGDEEAGTEEAVPRRNGAAGPHSPDPLLDEQAFGDLTDLPVVPKATY
GLKHAESIMSFHIDLGPSMLGDVLSIMDKEEWDPEEGEGGYHGDEGAAGTITQAPPYAVAAPPLARQEGKAGPDLPSLPSHALEDEGWAA

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Fusion Gene PPI Analysis for KLK3-CDC42EP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLK3-CDC42EP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLK3-CDC42EP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource