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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLK3-PSMD7 (FusionGDB2 ID:43090)

Fusion Gene Summary for KLK3-PSMD7

Fusion gene summary

Fusion gene information	Fusion gene name: KLK3-PSMD7
	Fusion gene ID: 43090
		Hgene	Tgene
	Gene symbol	KLK3	PSMD7
	Gene ID	3818	5713
	Gene name	kallikrein B1	proteasome 26S subunit, non-ATPase 7
	Synonyms	KLK3\|PKK\|PKKD\|PPK	MOV34\|P40\|Rpn8\|S12
	Cytomap	4q35.2	16q23.1
	Type of gene	protein-coding	protein-coding
	Description	plasma kallikreinkallikrein B, plasma (Fletcher factor) 1kininogeninplasma prekallikrein	26S proteasome non-ATPase regulatory subunit 726S proteasome regulatory subunit S1226S proteasome regulatory subunit rpn8Moloney leukemia virus-34 proviral integrationMov34 homologproteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homo
	Modification date	20200320	20200313
	UniProtAcc	P07288	.
	Ensembl transtripts involved in fusion gene	ENST00000326003, ENST00000360617, ENST00000593997, ENST00000595952, ENST00000597483,	ENST00000540379, ENST00000567958, ENST00000568615, ENST00000219313,
Fusion gene scores	* DoF score	24 X 31 X 2=1488	4 X 3 X 2=24
	# samples	31	4
	** MAII score	log2(31/1488*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: KLK3 [Title/Abstract] AND PSMD7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLK3(51361508)-PSMD7(74330845), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KLK3	GO:0031639	plasminogen activation	89876
Hgene	KLK3	GO:0051919	positive regulation of fibrinolysis	89876

Fusion gene breakpoints across KLK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PSMD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF858256	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+

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Fusion Gene ORF analysis for KLK3-PSMD7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000326003	ENST00000540379	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000326003	ENST00000567958	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000326003	ENST00000568615	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000360617	ENST00000540379	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000360617	ENST00000567958	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000360617	ENST00000568615	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000593997	ENST00000540379	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000593997	ENST00000567958	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000593997	ENST00000568615	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000595952	ENST00000540379	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000595952	ENST00000567958	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000595952	ENST00000568615	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000597483	ENST00000540379	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000597483	ENST00000567958	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
5CDS-5UTR	ENST00000597483	ENST00000568615	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
In-frame	ENST00000326003	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
In-frame	ENST00000360617	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
In-frame	ENST00000593997	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
In-frame	ENST00000595952	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+
In-frame	ENST00000597483	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000326003

KLK3

chr19

51361508

ENST00000219313

PSMD7

chr16

74330845

1807

310

1251

406

ENST00000597483

KLK3

chr19

51361508

ENST00000219313

PSMD7

chr16

74330845

1792

295

1236

406

ENST00000593997

KLK3

chr19

51361508

ENST00000219313

PSMD7

chr16

74330845

1787

290

1231

406

ENST00000595952

KLK3

chr19

51361508

ENST00000219313

PSMD7

chr16

74330845

1773

276

1217

375

ENST00000360617

KLK3

chr19

51361508

ENST00000219313

PSMD7

chr16

74330845

1766

269

1210

375

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000326003	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+	0.001422073	0.99857795
ENST00000597483	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+	0.001280023	0.99872005
ENST00000593997	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+	0.001345193	0.9986547
ENST00000595952	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+	0.001201596	0.9987984
ENST00000360617	ENST00000219313	KLK3	chr19	51361508	+	PSMD7	chr16	74330845	+	0.00128861	0.99871135

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Fusion Genomic Features for KLK3-PSMD7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLK3-PSMD7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51361508/chr16:74330845)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLK3 P07288	.
FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PSMD7

chr19:51361508

chr16:74330845

ENST00000219313

286_324

325.0

Compositional bias

Note=Glu/Lys-rich

Tgene

PSMD7

chr19:51361508

chr16:74330845

ENST00000219313

9_144

325.0

Domain

MPN

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLK3

chr19:51361508

chr16:74330845

ENST00000326003

25_258

262.0

Domain

Peptidase S1

Hgene

KLK3

chr19:51361508

chr16:74330845

ENST00000360617

25_258

239.0

Domain

Peptidase S1

Hgene

KLK3

chr19:51361508

chr16:74330845

ENST00000593997

25_258

228.0

Domain

Peptidase S1

Hgene

KLK3

chr19:51361508

chr16:74330845

ENST00000595952

25_258

219.0

Domain

Peptidase S1

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Fusion Gene Sequence for KLK3-PSMD7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43090_43090_1_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000326003_PSMD7_chr16_74330845_ENST00000219313_length(transcript)=1807nt_BP=310nt
AGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTG
CTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCA
GGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAAAGGAGCCAGCACTGGGGACCACC
TGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTCACCCCCTGGTGCTGCTCAGTGTGGTGGATCATTTCAACCGAATCGGCAA
GGTTGGAAACCAGAAGCGTGTTGTTGGTGTGCTTTTGGGGTCATGGCAAAAGAAAGTACTTGATGTATCGAACAGTTTTGCAGTTCCTTT
TGATGAAGATGACAAAGACGATTCTGTATGGTTTTTAGACCATGATTATTTGGAAAACATGTATGGAATGTTTAAGAAAGTCAATGCCAG
GGAAAGAATAGTTGGCTGGTACCACACAGGCCCTAAACTACACAAGAATGACATTGCCATCAACGAACTCATGAAAAGATACTGTCCTAA
TTCCGTATTGGTCATCATTGATGTGAAGCCGAAGGACCTAGGGCTGCCTACAGAAGCGTACATTTCAGTGGAAGAAGTCCATGATGATGG
AACTCCAACCTCGAAAACATTTGAACACGTGACCAGTGAAATTGGAGCAGAGGAAGCTGAGGAAGTTGGAGTTGAACACTTGTTACGAGA
TATCAAAGACACGACGGTGGGCACTCTGTCCCAGCGGATCACAAACCAGGTCCATGGTTTGAAGGGACTGAACTCCAAGCTTCTGGATAT
CAGGAGCTACCTGGAAAAAGTCGCCACAGGCAAGCTGCCCATCAACCACCAGATCATCTACCAGCTGCAGGACGTCTTCAACCTGCTGCC
AGATGTCAGCCTGCAGGAGTTCGTCAAGGCCTTTTACCTGAAGACCAATGACCAGATGGTGGTAGTGTACTTGGCCTCGCTGATCCGTTC
CGTGGTCGCCCTGCACAACCTCATCAACAACAAGATTGCCAACCGGGATGCAGAGAAGAAAGAAGGGCAGGAGAAAGAAGAGAGCAAAAA
GGATAGGAAAGAGGACAAGGAGAAAGATAAAGATAAGGAAAAGAGTGATGTAAAGAAAGAGGAGAAAAAGGAGAAAAAGTAAAACATGTA
TTAAATAGCTTTTTTAATTTGTAAATTAAAATCTTACAAACTAAATCAGTGTGCTGCTAGAGGGTTCTTTTTCACTTGACATGCTTATTA
GAAAGCTGACCCAACAAGAGCTCTCTGCCTCCGGTCACTCTTGCTGTGGTGCTACGTGGAAGTGAATGGAGACTGATCTCAAATCTGAAC
TGCAGCTTTCGCTGCTGTGAGTTGGGGATATGATAGTCAGCTCAGGCTTCAGATTGTATGAGAAAAATGAAGAGAAGTCAACAAATATTT
TGGTACTCTTCATTCATTTATCTCTAAAACCAGGAGTTGAATTTTCCTCATCTTGAAAGACTCTTGGGGTCTGTTTCTGGTATTTTACAA
AATTGCTAAGTGGAATGCATGAATTGCATTATGTTCTCTGGTAACACGTAGAGTTCAGACCCTTCTGAACTCTGTTGATAATACCACACC
ATGTTCTGGACCCATAGCTCTGGCATCCTCAGGGGTTGTGATCCAGCTCCATATATTGTTTACCTTCAAAGATACAATTAAATGGCTTGA

>43090_43090_1_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000326003_PSMD7_chr16_74330845_ENST00000219313_length(amino acids)=406AA_BP=93
MCHHVGPGCLPHPVRDVDWCCTPHPVSDCGRLGVREAFPTLAGACGLSWQGSLRRCSGAPPVGPHSCPLHQERSQHWGPPATPQAGAALN
QRSHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTG
PKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLS
QRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINN

--------------------------------------------------------------
>43090_43090_2_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000360617_PSMD7_chr16_74330845_ENST00000219313_length(transcript)=1766nt_BP=269nt
ATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAG
TGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTC
CTCACAGCTGCCCACTGCATCAGGAAAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTC
ACCCCCTGGTGCTGCTCAGTGTGGTGGATCATTTCAACCGAATCGGCAAGGTTGGAAACCAGAAGCGTGTTGTTGGTGTGCTTTTGGGGT
CATGGCAAAAGAAAGTACTTGATGTATCGAACAGTTTTGCAGTTCCTTTTGATGAAGATGACAAAGACGATTCTGTATGGTTTTTAGACC
ATGATTATTTGGAAAACATGTATGGAATGTTTAAGAAAGTCAATGCCAGGGAAAGAATAGTTGGCTGGTACCACACAGGCCCTAAACTAC
ACAAGAATGACATTGCCATCAACGAACTCATGAAAAGATACTGTCCTAATTCCGTATTGGTCATCATTGATGTGAAGCCGAAGGACCTAG
GGCTGCCTACAGAAGCGTACATTTCAGTGGAAGAAGTCCATGATGATGGAACTCCAACCTCGAAAACATTTGAACACGTGACCAGTGAAA
TTGGAGCAGAGGAAGCTGAGGAAGTTGGAGTTGAACACTTGTTACGAGATATCAAAGACACGACGGTGGGCACTCTGTCCCAGCGGATCA
CAAACCAGGTCCATGGTTTGAAGGGACTGAACTCCAAGCTTCTGGATATCAGGAGCTACCTGGAAAAAGTCGCCACAGGCAAGCTGCCCA
TCAACCACCAGATCATCTACCAGCTGCAGGACGTCTTCAACCTGCTGCCAGATGTCAGCCTGCAGGAGTTCGTCAAGGCCTTTTACCTGA
AGACCAATGACCAGATGGTGGTAGTGTACTTGGCCTCGCTGATCCGTTCCGTGGTCGCCCTGCACAACCTCATCAACAACAAGATTGCCA
ACCGGGATGCAGAGAAGAAAGAAGGGCAGGAGAAAGAAGAGAGCAAAAAGGATAGGAAAGAGGACAAGGAGAAAGATAAAGATAAGGAAA
AGAGTGATGTAAAGAAAGAGGAGAAAAAGGAGAAAAAGTAAAACATGTATTAAATAGCTTTTTTAATTTGTAAATTAAAATCTTACAAAC
TAAATCAGTGTGCTGCTAGAGGGTTCTTTTTCACTTGACATGCTTATTAGAAAGCTGACCCAACAAGAGCTCTCTGCCTCCGGTCACTCT
TGCTGTGGTGCTACGTGGAAGTGAATGGAGACTGATCTCAAATCTGAACTGCAGCTTTCGCTGCTGTGAGTTGGGGATATGATAGTCAGC
TCAGGCTTCAGATTGTATGAGAAAAATGAAGAGAAGTCAACAAATATTTTGGTACTCTTCATTCATTTATCTCTAAAACCAGGAGTTGAA
TTTTCCTCATCTTGAAAGACTCTTGGGGTCTGTTTCTGGTATTTTACAAAATTGCTAAGTGGAATGCATGAATTGCATTATGTTCTCTGG
TAACACGTAGAGTTCAGACCCTTCTGAACTCTGTTGATAATACCACACCATGTTCTGGACCCATAGCTCTGGCATCCTCAGGGGTTGTGA

>43090_43090_2_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000360617_PSMD7_chr16_74330845_ENST00000219313_length(amino acids)=375AA_BP=62
MGVREAFPTLAGACGLSWQGSLRRCSGAPPVGPHSCPLHQERSQHWGPPATPQAGAALNQRSHPLVLLSVVDHFNRIGKVGNQKRVVGVL
LGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPK
DLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGK
LPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKD

--------------------------------------------------------------
>43090_43090_3_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000593997_PSMD7_chr16_74330845_ENST00000219313_length(transcript)=1787nt_BP=290nt
CACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCT
CGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTT
CTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAAAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGG
CAGCATTGAACCAGAGGAGTCACCCCCTGGTGCTGCTCAGTGTGGTGGATCATTTCAACCGAATCGGCAAGGTTGGAAACCAGAAGCGTG
TTGTTGGTGTGCTTTTGGGGTCATGGCAAAAGAAAGTACTTGATGTATCGAACAGTTTTGCAGTTCCTTTTGATGAAGATGACAAAGACG
ATTCTGTATGGTTTTTAGACCATGATTATTTGGAAAACATGTATGGAATGTTTAAGAAAGTCAATGCCAGGGAAAGAATAGTTGGCTGGT
ACCACACAGGCCCTAAACTACACAAGAATGACATTGCCATCAACGAACTCATGAAAAGATACTGTCCTAATTCCGTATTGGTCATCATTG
ATGTGAAGCCGAAGGACCTAGGGCTGCCTACAGAAGCGTACATTTCAGTGGAAGAAGTCCATGATGATGGAACTCCAACCTCGAAAACAT
TTGAACACGTGACCAGTGAAATTGGAGCAGAGGAAGCTGAGGAAGTTGGAGTTGAACACTTGTTACGAGATATCAAAGACACGACGGTGG
GCACTCTGTCCCAGCGGATCACAAACCAGGTCCATGGTTTGAAGGGACTGAACTCCAAGCTTCTGGATATCAGGAGCTACCTGGAAAAAG
TCGCCACAGGCAAGCTGCCCATCAACCACCAGATCATCTACCAGCTGCAGGACGTCTTCAACCTGCTGCCAGATGTCAGCCTGCAGGAGT
TCGTCAAGGCCTTTTACCTGAAGACCAATGACCAGATGGTGGTAGTGTACTTGGCCTCGCTGATCCGTTCCGTGGTCGCCCTGCACAACC
TCATCAACAACAAGATTGCCAACCGGGATGCAGAGAAGAAAGAAGGGCAGGAGAAAGAAGAGAGCAAAAAGGATAGGAAAGAGGACAAGG
AGAAAGATAAAGATAAGGAAAAGAGTGATGTAAAGAAAGAGGAGAAAAAGGAGAAAAAGTAAAACATGTATTAAATAGCTTTTTTAATTT
GTAAATTAAAATCTTACAAACTAAATCAGTGTGCTGCTAGAGGGTTCTTTTTCACTTGACATGCTTATTAGAAAGCTGACCCAACAAGAG
CTCTCTGCCTCCGGTCACTCTTGCTGTGGTGCTACGTGGAAGTGAATGGAGACTGATCTCAAATCTGAACTGCAGCTTTCGCTGCTGTGA
GTTGGGGATATGATAGTCAGCTCAGGCTTCAGATTGTATGAGAAAAATGAAGAGAAGTCAACAAATATTTTGGTACTCTTCATTCATTTA
TCTCTAAAACCAGGAGTTGAATTTTCCTCATCTTGAAAGACTCTTGGGGTCTGTTTCTGGTATTTTACAAAATTGCTAAGTGGAATGCAT
GAATTGCATTATGTTCTCTGGTAACACGTAGAGTTCAGACCCTTCTGAACTCTGTTGATAATACCACACCATGTTCTGGACCCATAGCTC

>43090_43090_3_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000593997_PSMD7_chr16_74330845_ENST00000219313_length(amino acids)=406AA_BP=93
MCHHVGPGCLPHPVRDVDWCCTPHPVSDCGRLGVREAFPTLAGACGLSWQGSLRRCSGAPPVGPHSCPLHQERSQHWGPPATPQAGAALN
QRSHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTG
PKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLS
QRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINN

--------------------------------------------------------------
>43090_43090_4_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000595952_PSMD7_chr16_74330845_ENST00000219313_length(transcript)=1773nt_BP=276nt
TGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGG
CTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCA
GTGGGTCCTCACAGCTGCCCACTGCATCAGGAAAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAG
AGGAGTCACCCCCTGGTGCTGCTCAGTGTGGTGGATCATTTCAACCGAATCGGCAAGGTTGGAAACCAGAAGCGTGTTGTTGGTGTGCTT
TTGGGGTCATGGCAAAAGAAAGTACTTGATGTATCGAACAGTTTTGCAGTTCCTTTTGATGAAGATGACAAAGACGATTCTGTATGGTTT
TTAGACCATGATTATTTGGAAAACATGTATGGAATGTTTAAGAAAGTCAATGCCAGGGAAAGAATAGTTGGCTGGTACCACACAGGCCCT
AAACTACACAAGAATGACATTGCCATCAACGAACTCATGAAAAGATACTGTCCTAATTCCGTATTGGTCATCATTGATGTGAAGCCGAAG
GACCTAGGGCTGCCTACAGAAGCGTACATTTCAGTGGAAGAAGTCCATGATGATGGAACTCCAACCTCGAAAACATTTGAACACGTGACC
AGTGAAATTGGAGCAGAGGAAGCTGAGGAAGTTGGAGTTGAACACTTGTTACGAGATATCAAAGACACGACGGTGGGCACTCTGTCCCAG
CGGATCACAAACCAGGTCCATGGTTTGAAGGGACTGAACTCCAAGCTTCTGGATATCAGGAGCTACCTGGAAAAAGTCGCCACAGGCAAG
CTGCCCATCAACCACCAGATCATCTACCAGCTGCAGGACGTCTTCAACCTGCTGCCAGATGTCAGCCTGCAGGAGTTCGTCAAGGCCTTT
TACCTGAAGACCAATGACCAGATGGTGGTAGTGTACTTGGCCTCGCTGATCCGTTCCGTGGTCGCCCTGCACAACCTCATCAACAACAAG
ATTGCCAACCGGGATGCAGAGAAGAAAGAAGGGCAGGAGAAAGAAGAGAGCAAAAAGGATAGGAAAGAGGACAAGGAGAAAGATAAAGAT
AAGGAAAAGAGTGATGTAAAGAAAGAGGAGAAAAAGGAGAAAAAGTAAAACATGTATTAAATAGCTTTTTTAATTTGTAAATTAAAATCT
TACAAACTAAATCAGTGTGCTGCTAGAGGGTTCTTTTTCACTTGACATGCTTATTAGAAAGCTGACCCAACAAGAGCTCTCTGCCTCCGG
TCACTCTTGCTGTGGTGCTACGTGGAAGTGAATGGAGACTGATCTCAAATCTGAACTGCAGCTTTCGCTGCTGTGAGTTGGGGATATGAT
AGTCAGCTCAGGCTTCAGATTGTATGAGAAAAATGAAGAGAAGTCAACAAATATTTTGGTACTCTTCATTCATTTATCTCTAAAACCAGG
AGTTGAATTTTCCTCATCTTGAAAGACTCTTGGGGTCTGTTTCTGGTATTTTACAAAATTGCTAAGTGGAATGCATGAATTGCATTATGT
TCTCTGGTAACACGTAGAGTTCAGACCCTTCTGAACTCTGTTGATAATACCACACCATGTTCTGGACCCATAGCTCTGGCATCCTCAGGG

>43090_43090_4_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000595952_PSMD7_chr16_74330845_ENST00000219313_length(amino acids)=375AA_BP=62
MGVREAFPTLAGACGLSWQGSLRRCSGAPPVGPHSCPLHQERSQHWGPPATPQAGAALNQRSHPLVLLSVVDHFNRIGKVGNQKRVVGVL
LGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPK
DLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGK
LPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKD

--------------------------------------------------------------
>43090_43090_5_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000597483_PSMD7_chr16_74330845_ENST00000219313_length(transcript)=1792nt_BP=295nt
ACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCC
TGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCG
GTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAAAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGC
TGGGGCAGCATTGAACCAGAGGAGTCACCCCCTGGTGCTGCTCAGTGTGGTGGATCATTTCAACCGAATCGGCAAGGTTGGAAACCAGAA
GCGTGTTGTTGGTGTGCTTTTGGGGTCATGGCAAAAGAAAGTACTTGATGTATCGAACAGTTTTGCAGTTCCTTTTGATGAAGATGACAA
AGACGATTCTGTATGGTTTTTAGACCATGATTATTTGGAAAACATGTATGGAATGTTTAAGAAAGTCAATGCCAGGGAAAGAATAGTTGG
CTGGTACCACACAGGCCCTAAACTACACAAGAATGACATTGCCATCAACGAACTCATGAAAAGATACTGTCCTAATTCCGTATTGGTCAT
CATTGATGTGAAGCCGAAGGACCTAGGGCTGCCTACAGAAGCGTACATTTCAGTGGAAGAAGTCCATGATGATGGAACTCCAACCTCGAA
AACATTTGAACACGTGACCAGTGAAATTGGAGCAGAGGAAGCTGAGGAAGTTGGAGTTGAACACTTGTTACGAGATATCAAAGACACGAC
GGTGGGCACTCTGTCCCAGCGGATCACAAACCAGGTCCATGGTTTGAAGGGACTGAACTCCAAGCTTCTGGATATCAGGAGCTACCTGGA
AAAAGTCGCCACAGGCAAGCTGCCCATCAACCACCAGATCATCTACCAGCTGCAGGACGTCTTCAACCTGCTGCCAGATGTCAGCCTGCA
GGAGTTCGTCAAGGCCTTTTACCTGAAGACCAATGACCAGATGGTGGTAGTGTACTTGGCCTCGCTGATCCGTTCCGTGGTCGCCCTGCA
CAACCTCATCAACAACAAGATTGCCAACCGGGATGCAGAGAAGAAAGAAGGGCAGGAGAAAGAAGAGAGCAAAAAGGATAGGAAAGAGGA
CAAGGAGAAAGATAAAGATAAGGAAAAGAGTGATGTAAAGAAAGAGGAGAAAAAGGAGAAAAAGTAAAACATGTATTAAATAGCTTTTTT
AATTTGTAAATTAAAATCTTACAAACTAAATCAGTGTGCTGCTAGAGGGTTCTTTTTCACTTGACATGCTTATTAGAAAGCTGACCCAAC
AAGAGCTCTCTGCCTCCGGTCACTCTTGCTGTGGTGCTACGTGGAAGTGAATGGAGACTGATCTCAAATCTGAACTGCAGCTTTCGCTGC
TGTGAGTTGGGGATATGATAGTCAGCTCAGGCTTCAGATTGTATGAGAAAAATGAAGAGAAGTCAACAAATATTTTGGTACTCTTCATTC
ATTTATCTCTAAAACCAGGAGTTGAATTTTCCTCATCTTGAAAGACTCTTGGGGTCTGTTTCTGGTATTTTACAAAATTGCTAAGTGGAA
TGCATGAATTGCATTATGTTCTCTGGTAACACGTAGAGTTCAGACCCTTCTGAACTCTGTTGATAATACCACACCATGTTCTGGACCCAT

>43090_43090_5_KLK3-PSMD7_KLK3_chr19_51361508_ENST00000597483_PSMD7_chr16_74330845_ENST00000219313_length(amino acids)=406AA_BP=93
MCHHVGPGCLPHPVRDVDWCCTPHPVSDCGRLGVREAFPTLAGACGLSWQGSLRRCSGAPPVGPHSCPLHQERSQHWGPPATPQAGAALN
QRSHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTG
PKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLS
QRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KLK3-PSMD7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KLK3-PSMD7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KLK3-PSMD7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source