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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KLK3-TMPRSS11A (FusionGDB2 ID:43097)

Fusion Gene Summary for KLK3-TMPRSS11A

check button Fusion gene summary
Fusion gene informationFusion gene name: KLK3-TMPRSS11A
Fusion gene ID: 43097
HgeneTgene
Gene symbol

KLK3

TMPRSS11A

Gene ID

3818

339967

Gene namekallikrein B1transmembrane serine protease 11A
SynonymsKLK3|PKK|PKKD|PPKECRG1
Cytomap

4q35.2

4q13.2

Type of geneprotein-codingprotein-coding
Descriptionplasma kallikreinkallikrein B, plasma (Fletcher factor) 1kininogeninplasma prekallikreintransmembrane protease serine 11Aairway trypsin-like protease 1epidermal type-II transmembrane serine proteaseesophageal cancer-susceptibility gene 1 proteintransmembrane protease, serine 11A
Modification date2020032020200313
UniProtAcc

P07288

.
Ensembl transtripts involved in fusion geneENST00000326003, ENST00000360617, 
ENST00000593997, ENST00000595952, 
ENST00000597483, 		ENST00000334830, 
ENST00000508048, ENST00000396188, 
Fusion gene scores* DoF score24 X 31 X 2=14881 X 1 X 1=1
# samples 311
** MAII scorelog2(31/1488*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: KLK3 [Title/Abstract] AND TMPRSS11A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKLK3(51361851)-TMPRSS11A(68777221), # samples:4
Anticipated loss of major functional domain due to fusion event.KLK3-TMPRSS11A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KLK3-TMPRSS11A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKLK3

GO:0031639

plasminogen activation

89876

HgeneKLK3

GO:0051919

positive regulation of fibrinolysis

89876


check buttonFusion gene breakpoints across KLK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMPRSS11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5503KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
ChimerDB4PRADTCGA-EJ-A46FKLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
ChimerDB4PRADTCGA-HC-7742KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
ChimerDB4PRADTCGA-HC-7750KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-


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Fusion Gene ORF analysis for KLK3-TMPRSS11A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000326003ENST00000334830KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000326003ENST00000508048KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000360617ENST00000334830KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000360617ENST00000508048KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000593997ENST00000334830KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000593997ENST00000508048KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000595952ENST00000334830KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000595952ENST00000508048KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000597483ENST00000334830KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
Frame-shiftENST00000597483ENST00000508048KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
In-frameENST00000326003ENST00000396188KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
In-frameENST00000360617ENST00000396188KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
In-frameENST00000593997ENST00000396188KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
In-frameENST00000595952ENST00000396188KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-
In-frameENST00000597483ENST00000396188KLK3chr19

51361851

+TMPRSS11Achr4

68777221

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326003KLK3chr1951361851+ENST00000396188TMPRSS11Achr468777221-187467117832271
ENST00000597483KLK3chr1951361851+ENST00000396188TMPRSS11Achr468777221-17305272688228
ENST00000593997KLK3chr1951361851+ENST00000396188TMPRSS11Achr468777221-210189821542173
ENST00000595952KLK3chr1951361851+ENST00000396188TMPRSS11Achr468777221-17115087669220
ENST00000360617KLK3chr1951361851+ENST00000396188TMPRSS11Achr468777221-18336300791263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326003ENST00000396188KLK3chr1951361851+TMPRSS11Achr468777221-0.0062385690.9937615
ENST00000597483ENST00000396188KLK3chr1951361851+TMPRSS11Achr468777221-0.037954240.9620457
ENST00000593997ENST00000396188KLK3chr1951361851+TMPRSS11Achr468777221-0.534252760.46574724
ENST00000595952ENST00000396188KLK3chr1951361851+TMPRSS11Achr468777221-0.0337619970.966238
ENST00000360617ENST00000396188KLK3chr1951361851+TMPRSS11Achr468777221-0.0056048520.99439514

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Fusion Genomic Features for KLK3-TMPRSS11A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLK3-TMPRSS11A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51361851/chr4:68777221)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KLK3

P07288

.
FUNCTION: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKLK3chr19:51361851chr4:68777221ENST00000326003+4525_258210262.0DomainPeptidase S1
HgeneKLK3chr19:51361851chr4:68777221ENST00000360617+4525_258210239.0DomainPeptidase S1
HgeneKLK3chr19:51361851chr4:68777221ENST00000593997+1425_2580228.0DomainPeptidase S1
HgeneKLK3chr19:51361851chr4:68777221ENST00000595952+4525_258167219.0DomainPeptidase S1
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST00000334830810190_420368422.0DomainPeptidase S1
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST0000033483081047_167368422.0DomainSEA
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST00000508048810190_420364418.0DomainPeptidase S1
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST0000050804881047_167364418.0DomainSEA
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST000003348308101_18368422.0Topological domainCytoplasmic
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST0000033483081040_421368422.0Topological domainExtracellular
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST000005080488101_18364418.0Topological domainCytoplasmic
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST0000050804881040_421364418.0Topological domainExtracellular
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST0000033483081019_39368422.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS11Achr19:51361851chr4:68777221ENST0000050804881019_39364418.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for KLK3-TMPRSS11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43097_43097_1_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000326003_TMPRSS11A_chr4_68777221_ENST00000396188_length(transcript)=1874nt_BP=671nt
AGCCCCAAGCTTACCACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTG
CTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCA
GGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTC
GGCACAGCCTGTTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGA
AGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGA
AGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGA
CCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGC
TGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGGGACCTTTAGTCACAAGGGATCTGAAAGATACGTGGT
ATCTCATTGGAATTGTAAGCTGGGGAGATAACTGTGGTCAAAAGGACAAGCCTGGAGTCTACACACAAGTGACTTATTACCGAAACTGGA
TTGCTTCAAAAACAGGCATCTAATTCACGATAAAAGTTAAACAAAGAAAGCTGTATGCAGGTCATATATGCATGAGAATTCAACTATTTA
GTGGGTGTAGTACAACAAAGTGATATTAAATTACTGGATCTAGTAACATGAAACACACAACGTAAGTTATTTAGAATCACTTTAATCAAC
CAATAATCCTTAGCCAATTTATAAGGGACTTTTATTTGTAAAGTAATGGATCTGGCTTGAAAAATACGGTAGAGATACTTAGCTCTTTAA
ATCACGAATGTTGAAGTACCAGTGAGACTCAATACATATTTTTGAAGATAGTCCATGGGATTTTTAGAATGTCGTTGTCAAGGGTCTCCT
TTTAACTGAGAAACTTTTTGAACTCACAAAGTGTTCAAGAAACCCTTGTATAATTCCCTACATTTCTCTCGAGCTCACAAATACTTTTTT
TTCTTTTTCCTTATTCAATCAGATTTTCCAAAGTACCTTTCCACCATAAGAAATGAATTTTCTACTTCTACACCCATTTGAGAGACACCA
ATAAAAGAAAGTCATATGTAGGAAACAAAGTCTGATAGTAAAACAAGCCAGAGATCTTCTAACTTTTTTTAGTTATAAAACCTCTAATTT
TTGGTGACTTTTCTACACACACACACACATACAGTCACATAGATATTCTTATCCTACAGATATAATCAGAAAAATCCCGATTAATGAATT
ATATATAGATAGATAGAGTGATTAGTTAATCAAAACTATATATTTGTTAAAAATTTGGGAGAAGGTGATGGTAATTTCATTAGTCCCAAA
ACACCGGCATAAGAAATTTGACATTTCACAGATGCACTTACATATTTTGACCACAAGGGGGAAATTTTGTGCATTATTATTGTAGGGTTA
AATGCCTGAAAAAAATAAGCATTTACTAATACCTTGAAAAATCAAAGAACATTATGTTCCTCCGTAGCAAGAAAAATTTTATGCCCTCGC

>43097_43097_1_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000326003_TMPRSS11A_chr4_68777221_ENST00000396188_length(amino acids)=271AA_BP=218
MHPESCVTMWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFH
PEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQ
CVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG

--------------------------------------------------------------
>43097_43097_2_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000360617_TMPRSS11A_chr4_68777221_ENST00000396188_length(transcript)=1833nt_BP=630nt
ATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGGCTGGGAG
TGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTC
CTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCCTGAAGACACAGGCCAGGTATTT
CAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGAC
CTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACC
ACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCC
AATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCG
GGTGATTCTGGGGGACCTTTAGTCACAAGGGATCTGAAAGATACGTGGTATCTCATTGGAATTGTAAGCTGGGGAGATAACTGTGGTCAA
AAGGACAAGCCTGGAGTCTACACACAAGTGACTTATTACCGAAACTGGATTGCTTCAAAAACAGGCATCTAATTCACGATAAAAGTTAAA
CAAAGAAAGCTGTATGCAGGTCATATATGCATGAGAATTCAACTATTTAGTGGGTGTAGTACAACAAAGTGATATTAAATTACTGGATCT
AGTAACATGAAACACACAACGTAAGTTATTTAGAATCACTTTAATCAACCAATAATCCTTAGCCAATTTATAAGGGACTTTTATTTGTAA
AGTAATGGATCTGGCTTGAAAAATACGGTAGAGATACTTAGCTCTTTAAATCACGAATGTTGAAGTACCAGTGAGACTCAATACATATTT
TTGAAGATAGTCCATGGGATTTTTAGAATGTCGTTGTCAAGGGTCTCCTTTTAACTGAGAAACTTTTTGAACTCACAAAGTGTTCAAGAA
ACCCTTGTATAATTCCCTACATTTCTCTCGAGCTCACAAATACTTTTTTTTCTTTTTCCTTATTCAATCAGATTTTCCAAAGTACCTTTC
CACCATAAGAAATGAATTTTCTACTTCTACACCCATTTGAGAGACACCAATAAAAGAAAGTCATATGTAGGAAACAAAGTCTGATAGTAA
AACAAGCCAGAGATCTTCTAACTTTTTTTAGTTATAAAACCTCTAATTTTTGGTGACTTTTCTACACACACACACACATACAGTCACATA
GATATTCTTATCCTACAGATATAATCAGAAAAATCCCGATTAATGAATTATATATAGATAGATAGAGTGATTAGTTAATCAAAACTATAT
ATTTGTTAAAAATTTGGGAGAAGGTGATGGTAATTTCATTAGTCCCAAAACACCGGCATAAGAAATTTGACATTTCACAGATGCACTTAC
ATATTTTGACCACAAGGGGGAAATTTTGTGCATTATTATTGTAGGGTTAAATGCCTGAAAAAAATAAGCATTTACTAATACCTTGAAAAA
TCAAAGAACATTATGTTCCTCCGTAGCAAGAAAAATTTTATGCCCTCGCATTGCTACAGCCAAATAGCTTATAAGGCTTATGGCAATGTC

>43097_43097_2_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000360617_TMPRSS11A_chr4_68777221_ENST00000396188_length(amino acids)=263AA_BP=210
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVF
QVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVIS

--------------------------------------------------------------
>43097_43097_3_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000593997_TMPRSS11A_chr4_68777221_ENST00000396188_length(transcript)=2101nt_BP=898nt
CACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCT
CGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTT
CTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTGTTTCATCCT
GAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTCTACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCA
GGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACC
CAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGAACCAGAGGAGTGTGAGTCATCCCTACTCCCAAGATCT
TGAGGGGAAAGGTGAGTGGGGACCTTAATTCTGGGCTGGGGTCTAGAAGCCAACAAGGCGTCTGCCTCCCCTGCTCCCCAGCTGTAGCCA
TGCCACCTCCCCGTGTCTCATCTCATTCCCTCCTTCCCTCTTCTTTGACTCCCTCAAGGCAATAGGTTATTCTTACAGCACAACTCATCT
GTTCCTGCGTTCAGCACACGGTTACTAGGCACCTGCTATGCACCCAGCACTGCCCTAGAGCCTGGGACATAGCAGTGAACAGACAGAGAG
CAGCCCCTCCCTTCTGTAGCCCCCAAGCCAGTGAGGGGCACAGGCAGGAACAGGGACCACAACACAGAAAAGCTGGAGGGTGTCAGGAGG
TGATTCTGGGGGACCTTTAGTCACAAGGGATCTGAAAGATACGTGGTATCTCATTGGAATTGTAAGCTGGGGAGATAACTGTGGTCAAAA
GGACAAGCCTGGAGTCTACACACAAGTGACTTATTACCGAAACTGGATTGCTTCAAAAACAGGCATCTAATTCACGATAAAAGTTAAACA
AAGAAAGCTGTATGCAGGTCATATATGCATGAGAATTCAACTATTTAGTGGGTGTAGTACAACAAAGTGATATTAAATTACTGGATCTAG
TAACATGAAACACACAACGTAAGTTATTTAGAATCACTTTAATCAACCAATAATCCTTAGCCAATTTATAAGGGACTTTTATTTGTAAAG
TAATGGATCTGGCTTGAAAAATACGGTAGAGATACTTAGCTCTTTAAATCACGAATGTTGAAGTACCAGTGAGACTCAATACATATTTTT
GAAGATAGTCCATGGGATTTTTAGAATGTCGTTGTCAAGGGTCTCCTTTTAACTGAGAAACTTTTTGAACTCACAAAGTGTTCAAGAAAC
CCTTGTATAATTCCCTACATTTCTCTCGAGCTCACAAATACTTTTTTTTCTTTTTCCTTATTCAATCAGATTTTCCAAAGTACCTTTCCA
CCATAAGAAATGAATTTTCTACTTCTACACCCATTTGAGAGACACCAATAAAAGAAAGTCATATGTAGGAAACAAAGTCTGATAGTAAAA
CAAGCCAGAGATCTTCTAACTTTTTTTAGTTATAAAACCTCTAATTTTTGGTGACTTTTCTACACACACACACACATACAGTCACATAGA
TATTCTTATCCTACAGATATAATCAGAAAAATCCCGATTAATGAATTATATATAGATAGATAGAGTGATTAGTTAATCAAAACTATATAT
TTGTTAAAAATTTGGGAGAAGGTGATGGTAATTTCATTAGTCCCAAAACACCGGCATAAGAAATTTGACATTTCACAGATGCACTTACAT
ATTTTGACCACAAGGGGGAAATTTTGTGCATTATTATTGTAGGGTTAAATGCCTGAAAAAAATAAGCATTTACTAATACCTTGAAAAATC
AAAGAACATTATGTTCCTCCGTAGCAAGAAAAATTTTATGCCCTCGCATTGCTACAGCCAAATAGCTTATAAGGCTTATGGCAATGTCCC

>43097_43097_3_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000593997_TMPRSS11A_chr4_68777221_ENST00000396188_length(amino acids)=173AA_BP=
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVF

--------------------------------------------------------------
>43097_43097_4_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000595952_TMPRSS11A_chr4_68777221_ENST00000396188_length(transcript)=1711nt_BP=508nt
TGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCCTGTCTCGGATTGTGGGAGG
CTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCA
GTGGGTCCTCACAGCTGCCCACTGCATCAGGAAGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCCGCCTGTCAGAGCCTGCCGA
GCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATTGA
ACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTGCGCAAGTTCACCCTCAGAA
GGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGGGACCTTTAGTCACAAGGGA
TCTGAAAGATACGTGGTATCTCATTGGAATTGTAAGCTGGGGAGATAACTGTGGTCAAAAGGACAAGCCTGGAGTCTACACACAAGTGAC
TTATTACCGAAACTGGATTGCTTCAAAAACAGGCATCTAATTCACGATAAAAGTTAAACAAAGAAAGCTGTATGCAGGTCATATATGCAT
GAGAATTCAACTATTTAGTGGGTGTAGTACAACAAAGTGATATTAAATTACTGGATCTAGTAACATGAAACACACAACGTAAGTTATTTA
GAATCACTTTAATCAACCAATAATCCTTAGCCAATTTATAAGGGACTTTTATTTGTAAAGTAATGGATCTGGCTTGAAAAATACGGTAGA
GATACTTAGCTCTTTAAATCACGAATGTTGAAGTACCAGTGAGACTCAATACATATTTTTGAAGATAGTCCATGGGATTTTTAGAATGTC
GTTGTCAAGGGTCTCCTTTTAACTGAGAAACTTTTTGAACTCACAAAGTGTTCAAGAAACCCTTGTATAATTCCCTACATTTCTCTCGAG
CTCACAAATACTTTTTTTTCTTTTTCCTTATTCAATCAGATTTTCCAAAGTACCTTTCCACCATAAGAAATGAATTTTCTACTTCTACAC
CCATTTGAGAGACACCAATAAAAGAAAGTCATATGTAGGAAACAAAGTCTGATAGTAAAACAAGCCAGAGATCTTCTAACTTTTTTTAGT
TATAAAACCTCTAATTTTTGGTGACTTTTCTACACACACACACACATACAGTCACATAGATATTCTTATCCTACAGATATAATCAGAAAA
ATCCCGATTAATGAATTATATATAGATAGATAGAGTGATTAGTTAATCAAAACTATATATTTGTTAAAAATTTGGGAGAAGGTGATGGTA
ATTTCATTAGTCCCAAAACACCGGCATAAGAAATTTGACATTTCACAGATGCACTTACATATTTTGACCACAAGGGGGAAATTTTGTGCA
TTATTATTGTAGGGTTAAATGCCTGAAAAAAATAAGCATTTACTAATACCTTGAAAAATCAAAGAACATTATGTTCCTCCGTAGCAAGAA
AAATTTTATGCCCTCGCATTGCTACAGCCAAATAGCTTATAAGGCTTATGGCAATGTCCCAACTATTGCAATCATAAAACCCTAGTTTTA

>43097_43097_4_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000595952_TMPRSS11A_chr4_68777221_ENST00000396188_length(amino acids)=220AA_BP=167
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRKPGDDSSHDLMLLRLSEPAELT
DAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVTRDLK

--------------------------------------------------------------
>43097_43097_5_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000597483_TMPRSS11A_chr4_68777221_ENST00000396188_length(transcript)=1730nt_BP=527nt
ACCTGCACCCGGAGAGCTGTGTCACCATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTCATCC
TGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTGCTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCG
GTGTTCTGGTGCACCCCCAGTGGGTCCTCACAGCTGCCCACTGCATCAGGAAGCCAGGTGATGACTCCAGCCACGACCTCATGCTGCTCC
GCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGACCTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCT
CAGGCTGGGGCAGCATTGAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCCAATGACGTGTGTG
CGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGACGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGG
GACCTTTAGTCACAAGGGATCTGAAAGATACGTGGTATCTCATTGGAATTGTAAGCTGGGGAGATAACTGTGGTCAAAAGGACAAGCCTG
GAGTCTACACACAAGTGACTTATTACCGAAACTGGATTGCTTCAAAAACAGGCATCTAATTCACGATAAAAGTTAAACAAAGAAAGCTGT
ATGCAGGTCATATATGCATGAGAATTCAACTATTTAGTGGGTGTAGTACAACAAAGTGATATTAAATTACTGGATCTAGTAACATGAAAC
ACACAACGTAAGTTATTTAGAATCACTTTAATCAACCAATAATCCTTAGCCAATTTATAAGGGACTTTTATTTGTAAAGTAATGGATCTG
GCTTGAAAAATACGGTAGAGATACTTAGCTCTTTAAATCACGAATGTTGAAGTACCAGTGAGACTCAATACATATTTTTGAAGATAGTCC
ATGGGATTTTTAGAATGTCGTTGTCAAGGGTCTCCTTTTAACTGAGAAACTTTTTGAACTCACAAAGTGTTCAAGAAACCCTTGTATAAT
TCCCTACATTTCTCTCGAGCTCACAAATACTTTTTTTTCTTTTTCCTTATTCAATCAGATTTTCCAAAGTACCTTTCCACCATAAGAAAT
GAATTTTCTACTTCTACACCCATTTGAGAGACACCAATAAAAGAAAGTCATATGTAGGAAACAAAGTCTGATAGTAAAACAAGCCAGAGA
TCTTCTAACTTTTTTTAGTTATAAAACCTCTAATTTTTGGTGACTTTTCTACACACACACACACATACAGTCACATAGATATTCTTATCC
TACAGATATAATCAGAAAAATCCCGATTAATGAATTATATATAGATAGATAGAGTGATTAGTTAATCAAAACTATATATTTGTTAAAAAT
TTGGGAGAAGGTGATGGTAATTTCATTAGTCCCAAAACACCGGCATAAGAAATTTGACATTTCACAGATGCACTTACATATTTTGACCAC
AAGGGGGAAATTTTGTGCATTATTATTGTAGGGTTAAATGCCTGAAAAAAATAAGCATTTACTAATACCTTGAAAAATCAAAGAACATTA
TGTTCCTCCGTAGCAAGAAAAATTTTATGCCCTCGCATTGCTACAGCCAAATAGCTTATAAGGCTTATGGCAATGTCCCAACTATTGCAA

>43097_43097_5_KLK3-TMPRSS11A_KLK3_chr19_51361851_ENST00000597483_TMPRSS11A_chr4_68777221_ENST00000396188_length(amino acids)=228AA_BP=175
LHPESCVTMWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRKPGDDSSHDLMLLR
LSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGG

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Fusion Gene PPI Analysis for KLK3-TMPRSS11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KLK3-TMPRSS11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KLK3-TMPRSS11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource