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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KLK8-NLRP4 (FusionGDB2 ID:43107)

Fusion Gene Summary for KLK8-NLRP4

Fusion gene summary

Fusion gene information	Fusion gene name: KLK8-NLRP4
	Fusion gene ID: 43107
		Hgene	Tgene
	Gene symbol	KLK8	NLRP4
	Gene ID	11202	147945
	Gene name	kallikrein related peptidase 8	NLR family pyrin domain containing 4
	Synonyms	HNP\|NP\|NRPN\|PRSS19\|TADG14	CLR19.5\|CT58\|NALP4\|PAN2\|PYPAF4\|RNH2
	Cytomap	19q13.41	19q13.43
	Type of gene	protein-coding	protein-coding
	Description	kallikrein-8ovasinserine protease 19serine protease TADG-14tumor-associated differentially expressed gene 14 protein	NACHT, LRR and PYD domains-containing protein 4NACHT, leucine rich repeat and PYD containing 4PAAD and NACHT-containing protein 2PYRIN and NACHT-containing protein 2PYRIN-containing APAF1-like protein 4cancer/testis antigen 58nucleotide-binding olig
	Modification date	20200313	20200313
	UniProtAcc	O60259	.
	Ensembl transtripts involved in fusion gene	ENST00000598195, ENST00000291726, ENST00000347619, ENST00000391806, ENST00000593490, ENST00000600767, ENST00000320838,	ENST00000301295, ENST00000346986, ENST00000587891,
Fusion gene scores	* DoF score	1 X 3 X 1=3	5 X 7 X 4=140
	# samples	2	7
	** MAII score	log2(2/3*10)=2.73696559416621	log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KLK8 [Title/Abstract] AND NLRP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KLK8(51504353)-NLRP4(56388361), # samples:1 KLK8(51504354)-NLRP4(56388362), # samples:1 KLK8(51501007)-NLRP4(56388362), # samples:1
Anticipated loss of major functional domain due to fusion event.	KLK8-NLRP4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KLK8-NLRP4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KLK8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NLRP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-23-1024-01A	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
ChimerDB4	OV	TCGA-23-1024-01A	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
ChimerDB4	OV	TCGA-23-1024	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+

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Fusion Gene ORF analysis for KLK8-NLRP4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000598195	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
5UTR-3CDS	ENST00000598195	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
5UTR-3CDS	ENST00000598195	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000291726	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000291726	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000291726	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000347619	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000347619	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000347619	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000391806	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000391806	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000391806	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000593490	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000593490	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
Frame-shift	ENST00000593490	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000593490	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
Frame-shift	ENST00000593490	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000593490	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
Frame-shift	ENST00000600767	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000600767	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
Frame-shift	ENST00000600767	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000600767	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
Frame-shift	ENST00000600767	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
Frame-shift	ENST00000600767	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000291726	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000291726	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000291726	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000291726	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000291726	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000291726	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000320838	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000320838	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000320838	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000320838	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000320838	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000320838	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000347619	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000347619	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000347619	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000347619	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000347619	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000347619	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000391806	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000391806	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000391806	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000391806	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000391806	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
In-frame	ENST00000391806	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
In-frame	ENST00000600767	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
In-frame	ENST00000600767	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
In-frame	ENST00000600767	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000320838	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000320838	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000320838	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000593490	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000593490	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000593490	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000598195	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000598195	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
intron-3CDS	ENST00000598195	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000598195	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+
intron-3CDS	ENST00000598195	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+
intron-3CDS	ENST00000598195	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000391806	KLK8	chr19	51504353	-	ENST00000301295	NLRP4	chr19	56388361	+	874	151	59	610	183
ENST00000391806	KLK8	chr19	51504353	-	ENST00000346986	NLRP4	chr19	56388361	+	876	151	59	610	183
ENST00000391806	KLK8	chr19	51504353	-	ENST00000587891	NLRP4	chr19	56388361	+	878	151	59	610	183
ENST00000291726	KLK8	chr19	51504353	-	ENST00000301295	NLRP4	chr19	56388361	+	972	249	157	708	183
ENST00000291726	KLK8	chr19	51504353	-	ENST00000346986	NLRP4	chr19	56388361	+	974	249	157	708	183
ENST00000291726	KLK8	chr19	51504353	-	ENST00000587891	NLRP4	chr19	56388361	+	976	249	157	708	183
ENST00000320838	KLK8	chr19	51504353	-	ENST00000301295	NLRP4	chr19	56388361	+	972	249	157	708	183
ENST00000320838	KLK8	chr19	51504353	-	ENST00000346986	NLRP4	chr19	56388361	+	974	249	157	708	183
ENST00000320838	KLK8	chr19	51504353	-	ENST00000587891	NLRP4	chr19	56388361	+	976	249	157	708	183
ENST00000347619	KLK8	chr19	51504353	-	ENST00000301295	NLRP4	chr19	56388361	+	938	215	123	674	183
ENST00000347619	KLK8	chr19	51504353	-	ENST00000346986	NLRP4	chr19	56388361	+	940	215	123	674	183
ENST00000347619	KLK8	chr19	51504353	-	ENST00000587891	NLRP4	chr19	56388361	+	942	215	123	674	183
ENST00000391806	KLK8	chr19	51504354	-	ENST00000301295	NLRP4	chr19	56388362	+	874	151	59	610	183
ENST00000391806	KLK8	chr19	51504354	-	ENST00000346986	NLRP4	chr19	56388362	+	876	151	59	610	183
ENST00000391806	KLK8	chr19	51504354	-	ENST00000587891	NLRP4	chr19	56388362	+	878	151	59	610	183
ENST00000291726	KLK8	chr19	51504354	-	ENST00000301295	NLRP4	chr19	56388362	+	972	249	157	708	183
ENST00000291726	KLK8	chr19	51504354	-	ENST00000346986	NLRP4	chr19	56388362	+	974	249	157	708	183
ENST00000291726	KLK8	chr19	51504354	-	ENST00000587891	NLRP4	chr19	56388362	+	976	249	157	708	183
ENST00000320838	KLK8	chr19	51504354	-	ENST00000301295	NLRP4	chr19	56388362	+	972	249	157	708	183
ENST00000320838	KLK8	chr19	51504354	-	ENST00000346986	NLRP4	chr19	56388362	+	974	249	157	708	183
ENST00000320838	KLK8	chr19	51504354	-	ENST00000587891	NLRP4	chr19	56388362	+	976	249	157	708	183
ENST00000347619	KLK8	chr19	51504354	-	ENST00000301295	NLRP4	chr19	56388362	+	938	215	123	674	183
ENST00000347619	KLK8	chr19	51504354	-	ENST00000346986	NLRP4	chr19	56388362	+	940	215	123	674	183
ENST00000347619	KLK8	chr19	51504354	-	ENST00000587891	NLRP4	chr19	56388362	+	942	215	123	674	183
ENST00000600767	KLK8	chr19	51501007	-	ENST00000301295	NLRP4	chr19	56388362	+	1840	1117	475	1152	225
ENST00000600767	KLK8	chr19	51501007	-	ENST00000346986	NLRP4	chr19	56388362	+	1842	1117	475	1152	225
ENST00000600767	KLK8	chr19	51501007	-	ENST00000587891	NLRP4	chr19	56388362	+	1844	1117	475	1152	225

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000391806	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.90343773	0.09656231
ENST00000391806	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9036328	0.09636718
ENST00000391806	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9005786	0.09942135
ENST00000291726	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.93309075	0.066909224
ENST00000291726	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9342664	0.06573357
ENST00000291726	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9336454	0.06635459
ENST00000320838	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.93309075	0.066909224
ENST00000320838	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9342664	0.06573357
ENST00000320838	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9336454	0.06635459
ENST00000347619	ENST00000301295	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9578945	0.042105448
ENST00000347619	ENST00000346986	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9587488	0.04125118
ENST00000347619	ENST00000587891	KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.9578933	0.042106688
ENST00000391806	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.90343773	0.09656231
ENST00000391806	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9036328	0.09636718
ENST00000391806	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9005786	0.09942135
ENST00000291726	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.93309075	0.066909224
ENST00000291726	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9342664	0.06573357
ENST00000291726	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9336454	0.06635459
ENST00000320838	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.93309075	0.066909224
ENST00000320838	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9342664	0.06573357
ENST00000320838	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9336454	0.06635459
ENST00000347619	ENST00000301295	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9578945	0.042105448
ENST00000347619	ENST00000346986	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9587488	0.04125118
ENST00000347619	ENST00000587891	KLK8	chr19	51504354	-	NLRP4	chr19	56388362	+	0.9578933	0.042106688
ENST00000600767	ENST00000301295	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+	0.09738155	0.9026184
ENST00000600767	ENST00000346986	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+	0.09614783	0.9038522
ENST00000600767	ENST00000587891	KLK8	chr19	51501007	-	NLRP4	chr19	56388362	+	0.095603466	0.90439653

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Fusion Genomic Features for KLK8-NLRP4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.5861212	0.41387874
KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.5861212	0.41387874
KLK8	chr19	51501006	-	NLRP4	chr19	56388361	+	0.000109682	0.9998903
KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.5861212	0.41387874
KLK8	chr19	51504353	-	NLRP4	chr19	56388361	+	0.5861212	0.41387874
KLK8	chr19	51501006	-	NLRP4	chr19	56388361	+	0.000109682	0.9998903

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KLK8-NLRP4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51504353/chr19:56388361)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLK8 O60259	.
FUNCTION: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269\|PubMed:16337200}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLK8

chr19:51501007

chr19:56388362

ENST00000391806

33_257

254

306.0

Domain

Peptidase S1

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

863_886

841

995.0

Repeat

Note=LRR 6

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

920_943

841

995.0

Repeat

Note=LRR 7

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

949_972

841

995.0

Repeat

Note=LRR 8

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

806_833

766

920.0

Repeat

Note=LRR 5

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

863_886

766

920.0

Repeat

Note=LRR 6

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

920_943

766

920.0

Repeat

Note=LRR 7

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

949_972

766

920.0

Repeat

Note=LRR 8

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

863_886

841

995.0

Repeat

Note=LRR 6

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

920_943

841

995.0

Repeat

Note=LRR 7

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

949_972

841

995.0

Repeat

Note=LRR 8

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

806_833

766

920.0

Repeat

Note=LRR 5

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

863_886

766

920.0

Repeat

Note=LRR 6

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

920_943

766

920.0

Repeat

Note=LRR 7

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

949_972

766

920.0

Repeat

Note=LRR 8

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

863_886

841

995.0

Repeat

Note=LRR 6

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

920_943

841

995.0

Repeat

Note=LRR 7

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

949_972

841

995.0

Repeat

Note=LRR 8

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

806_833

766

920.0

Repeat

Note=LRR 5

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

863_886

766

920.0

Repeat

Note=LRR 6

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

920_943

766

920.0

Repeat

Note=LRR 7

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

949_972

766

920.0

Repeat

Note=LRR 8

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLK8

chr19:51501007

chr19:56388362

ENST00000291726

33_257

209

261.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51501007

chr19:56388362

ENST00000320838

33_257

33.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51501007

chr19:56388362

ENST00000347619

33_257

120.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51501007

chr19:56388362

ENST00000593490

33_257

33.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51501007

chr19:56388362

ENST00000600767

33_257

209

261.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504353

chr19:56388361

ENST00000291726

33_257

261.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504353

chr19:56388361

ENST00000320838

33_257

33.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504353

chr19:56388361

ENST00000347619

33_257

120.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504353

chr19:56388361

ENST00000391806

33_257

306.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504353

chr19:56388361

ENST00000593490

33_257

33.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504353

chr19:56388361

ENST00000600767

33_257

261.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504354

chr19:56388362

ENST00000291726

33_257

261.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504354

chr19:56388362

ENST00000320838

33_257

33.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504354

chr19:56388362

ENST00000347619

33_257

120.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504354

chr19:56388362

ENST00000391806

33_257

306.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504354

chr19:56388362

ENST00000593490

33_257

33.0

Domain

Peptidase S1

Hgene

KLK8

chr19:51504354

chr19:56388362

ENST00000600767

33_257

261.0

Domain

Peptidase S1

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

149_472

841

995.0

Domain

NACHT

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

1_94

841

995.0

Domain

Pyrin

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

149_472

766

920.0

Domain

NACHT

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

1_94

766

920.0

Domain

Pyrin

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

149_472

841

995.0

Domain

NACHT

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

1_94

841

995.0

Domain

Pyrin

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

149_472

766

920.0

Domain

NACHT

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

1_94

766

920.0

Domain

Pyrin

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

149_472

841

995.0

Domain

NACHT

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

1_94

841

995.0

Domain

Pyrin

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

149_472

766

920.0

Domain

NACHT

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

1_94

766

920.0

Domain

Pyrin

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

155_162

841

995.0

Nucleotide binding

ATP

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

155_162

766

920.0

Nucleotide binding

ATP

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

155_162

841

995.0

Nucleotide binding

ATP

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

155_162

766

920.0

Nucleotide binding

ATP

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

155_162

841

995.0

Nucleotide binding

ATP

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

155_162

766

920.0

Nucleotide binding

ATP

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

637_660

841

995.0

Repeat

Note=LRR 1

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

698_721

841

995.0

Repeat

Note=LRR 2

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

722_745

841

995.0

Repeat

Note=LRR 3

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

750_777

841

995.0

Repeat

Note=LRR 4

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000301295

806_833

841

995.0

Repeat

Note=LRR 5

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

637_660

766

920.0

Repeat

Note=LRR 1

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

698_721

766

920.0

Repeat

Note=LRR 2

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

722_745

766

920.0

Repeat

Note=LRR 3

Tgene

NLRP4

chr19:51501007

chr19:56388362

ENST00000587891

750_777

766

920.0

Repeat

Note=LRR 4

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

637_660

841

995.0

Repeat

Note=LRR 1

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

698_721

841

995.0

Repeat

Note=LRR 2

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

722_745

841

995.0

Repeat

Note=LRR 3

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

750_777

841

995.0

Repeat

Note=LRR 4

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000301295

806_833

841

995.0

Repeat

Note=LRR 5

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

637_660

766

920.0

Repeat

Note=LRR 1

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

698_721

766

920.0

Repeat

Note=LRR 2

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

722_745

766

920.0

Repeat

Note=LRR 3

Tgene

NLRP4

chr19:51504353

chr19:56388361

ENST00000587891

750_777

766

920.0

Repeat

Note=LRR 4

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

637_660

841

995.0

Repeat

Note=LRR 1

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

698_721

841

995.0

Repeat

Note=LRR 2

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

722_745

841

995.0

Repeat

Note=LRR 3

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

750_777

841

995.0

Repeat

Note=LRR 4

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000301295

806_833

841

995.0

Repeat

Note=LRR 5

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

637_660

766

920.0

Repeat

Note=LRR 1

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

698_721

766

920.0

Repeat

Note=LRR 2

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

722_745

766

920.0

Repeat

Note=LRR 3

Tgene

NLRP4

chr19:51504354

chr19:56388362

ENST00000587891

750_777

766

920.0

Repeat

Note=LRR 4

Top

Fusion Gene Sequence for KLK8-NLRP4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43107_43107_1_KLK8-NLRP4_KLK8_chr19_51501007_ENST00000600767_NLRP4_chr19_56388362_ENST00000301295_length(transcript)=1840nt_BP=1117nt
CGCCCCTCGTGATGTCAGGGGCGCAGTAGCTCCGCCCACGTGGAGCTCGGGCGGTGTAGAGCTCAGCCCCTTGTGGCCCCGTCCTGGGCG
TGTGCTGGGTTTGAATCCTGGCGGAGACCTGGGGGGAAATTGAGGGAGGGTCTGGATACCTTTAGAGCCAATGCAACGGATGATTTTTCA
GTAAACGCGGGAAACCTCACCTTCTTTCTGCCTGAGCTGTGAGATGAGTGGAGAGCAAACGGGTGGGCGGTGAAGGGCAGATGAGGGAAC
CGGTACCGCCTTGCAACTCCCCCTTAAACCCCTATGTTCCAGTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAG
CAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAAT
CAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTT
GCTGGGGGGAGCCTGGGCAGGACACTCCAGGGCACAGGAGGACAAGGTGCTGGGGGGTCATGAGTGCCAACCCCATTCGCAGCCTTGGCA
GGCGGCCTTGTTCCAGGGCCAGCAACTACTCTGTGGCGGTGTCCTTGTAGGTGGCAACTGGGTCCTTACAGCTGCCCACTGTAAAAAACC
GAAATACACAGTACGCCTGGGAGACCACAGCCTACAGAATAAAGATGGCCCAGAGCAAGAAATACCTGTGGTTCAGTCCATCCCACACCC
CTGCTACAACAGCAGCGATGTGGAGGACCACAACCATGATCTGATGCTTCTTCAACTGCGTGACCAGGCATCCCTGGGGTCCAAAGTGAA
GCCCATCAGCCTGGCAGATCATTGCACCCAGCCTGGCCAGAAGTGCACCGTCTCAGGCTGGGGCACTGTCACCAGTCCCCGAGAGAATTT
TCCTGACACTCTCAACTGTGCAGAAGTAAAAATCTTTCCCCAGAAGAAGTGTGAGGATGCTTACCCGGGGCAGATCACAGATGGCATGGT
CTGTGCAGGCAGCAGCAAAGGGGCTGACACGTGCCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTC
TCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGC
ATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCA
GTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGT
GTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACC
TGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACA
GGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCAT
AGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGA

>43107_43107_1_KLK8-NLRP4_KLK8_chr19_51501007_ENST00000600767_NLRP4_chr19_56388362_ENST00000301295_length(amino acids)=225AA_BP=
MEDLTMGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGD
HSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAE

--------------------------------------------------------------
>43107_43107_2_KLK8-NLRP4_KLK8_chr19_51501007_ENST00000600767_NLRP4_chr19_56388362_ENST00000346986_length(transcript)=1842nt_BP=1117nt
CGCCCCTCGTGATGTCAGGGGCGCAGTAGCTCCGCCCACGTGGAGCTCGGGCGGTGTAGAGCTCAGCCCCTTGTGGCCCCGTCCTGGGCG
TGTGCTGGGTTTGAATCCTGGCGGAGACCTGGGGGGAAATTGAGGGAGGGTCTGGATACCTTTAGAGCCAATGCAACGGATGATTTTTCA
GTAAACGCGGGAAACCTCACCTTCTTTCTGCCTGAGCTGTGAGATGAGTGGAGAGCAAACGGGTGGGCGGTGAAGGGCAGATGAGGGAAC
CGGTACCGCCTTGCAACTCCCCCTTAAACCCCTATGTTCCAGTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAG
CAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAAT
CAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTT
GCTGGGGGGAGCCTGGGCAGGACACTCCAGGGCACAGGAGGACAAGGTGCTGGGGGGTCATGAGTGCCAACCCCATTCGCAGCCTTGGCA
GGCGGCCTTGTTCCAGGGCCAGCAACTACTCTGTGGCGGTGTCCTTGTAGGTGGCAACTGGGTCCTTACAGCTGCCCACTGTAAAAAACC
GAAATACACAGTACGCCTGGGAGACCACAGCCTACAGAATAAAGATGGCCCAGAGCAAGAAATACCTGTGGTTCAGTCCATCCCACACCC
CTGCTACAACAGCAGCGATGTGGAGGACCACAACCATGATCTGATGCTTCTTCAACTGCGTGACCAGGCATCCCTGGGGTCCAAAGTGAA
GCCCATCAGCCTGGCAGATCATTGCACCCAGCCTGGCCAGAAGTGCACCGTCTCAGGCTGGGGCACTGTCACCAGTCCCCGAGAGAATTT
TCCTGACACTCTCAACTGTGCAGAAGTAAAAATCTTTCCCCAGAAGAAGTGTGAGGATGCTTACCCGGGGCAGATCACAGATGGCATGGT
CTGTGCAGGCAGCAGCAAAGGGGCTGACACGTGCCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTC
TCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGC
ATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCA
GTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGT
GTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACC
TGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACA
GGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCAT
AGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGA

>43107_43107_2_KLK8-NLRP4_KLK8_chr19_51501007_ENST00000600767_NLRP4_chr19_56388362_ENST00000346986_length(amino acids)=225AA_BP=
MEDLTMGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGD
HSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAE

--------------------------------------------------------------
>43107_43107_3_KLK8-NLRP4_KLK8_chr19_51501007_ENST00000600767_NLRP4_chr19_56388362_ENST00000587891_length(transcript)=1844nt_BP=1117nt
CGCCCCTCGTGATGTCAGGGGCGCAGTAGCTCCGCCCACGTGGAGCTCGGGCGGTGTAGAGCTCAGCCCCTTGTGGCCCCGTCCTGGGCG
TGTGCTGGGTTTGAATCCTGGCGGAGACCTGGGGGGAAATTGAGGGAGGGTCTGGATACCTTTAGAGCCAATGCAACGGATGATTTTTCA
GTAAACGCGGGAAACCTCACCTTCTTTCTGCCTGAGCTGTGAGATGAGTGGAGAGCAAACGGGTGGGCGGTGAAGGGCAGATGAGGGAAC
CGGTACCGCCTTGCAACTCCCCCTTAAACCCCTATGTTCCAGTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAG
CAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAAT
CAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTT
GCTGGGGGGAGCCTGGGCAGGACACTCCAGGGCACAGGAGGACAAGGTGCTGGGGGGTCATGAGTGCCAACCCCATTCGCAGCCTTGGCA
GGCGGCCTTGTTCCAGGGCCAGCAACTACTCTGTGGCGGTGTCCTTGTAGGTGGCAACTGGGTCCTTACAGCTGCCCACTGTAAAAAACC
GAAATACACAGTACGCCTGGGAGACCACAGCCTACAGAATAAAGATGGCCCAGAGCAAGAAATACCTGTGGTTCAGTCCATCCCACACCC
CTGCTACAACAGCAGCGATGTGGAGGACCACAACCATGATCTGATGCTTCTTCAACTGCGTGACCAGGCATCCCTGGGGTCCAAAGTGAA
GCCCATCAGCCTGGCAGATCATTGCACCCAGCCTGGCCAGAAGTGCACCGTCTCAGGCTGGGGCACTGTCACCAGTCCCCGAGAGAATTT
TCCTGACACTCTCAACTGTGCAGAAGTAAAAATCTTTCCCCAGAAGAAGTGTGAGGATGCTTACCCGGGGCAGATCACAGATGGCATGGT
CTGTGCAGGCAGCAGCAAAGGGGCTGACACGTGCCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTC
TCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGC
ATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCA
GTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGT
GTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACC
TGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACA
GGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCAT
AGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGA

>43107_43107_3_KLK8-NLRP4_KLK8_chr19_51501007_ENST00000600767_NLRP4_chr19_56388362_ENST00000587891_length(amino acids)=225AA_BP=
MEDLTMGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGD
HSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAE

--------------------------------------------------------------
>43107_43107_4_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000291726_NLRP4_chr19_56388361_ENST00000301295_length(transcript)=972nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_4_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000291726_NLRP4_chr19_56388361_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_5_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000291726_NLRP4_chr19_56388361_ENST00000346986_length(transcript)=974nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_5_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000291726_NLRP4_chr19_56388361_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_6_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000291726_NLRP4_chr19_56388361_ENST00000587891_length(transcript)=976nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_6_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000291726_NLRP4_chr19_56388361_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_7_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000320838_NLRP4_chr19_56388361_ENST00000301295_length(transcript)=972nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_7_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000320838_NLRP4_chr19_56388361_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_8_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000320838_NLRP4_chr19_56388361_ENST00000346986_length(transcript)=974nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_8_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000320838_NLRP4_chr19_56388361_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_9_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000320838_NLRP4_chr19_56388361_ENST00000587891_length(transcript)=976nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_9_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000320838_NLRP4_chr19_56388361_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_10_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000347619_NLRP4_chr19_56388361_ENST00000301295_length(transcript)=938nt_BP=215nt
GAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCT
CCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTG
GATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTC
ATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCAT
ACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGT
AAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGTGT
GCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACCTG
ACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACAGG
GACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCATAG
ATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGACC

>43107_43107_10_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000347619_NLRP4_chr19_56388361_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_11_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000347619_NLRP4_chr19_56388361_ENST00000346986_length(transcript)=940nt_BP=215nt
GAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCT
CCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTG
GATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTC
ATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCAT
ACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGT
AAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGTGT
GCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACCTG
ACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACAGG
GACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCATAG
ATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGACC

>43107_43107_11_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000347619_NLRP4_chr19_56388361_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_12_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000347619_NLRP4_chr19_56388361_ENST00000587891_length(transcript)=942nt_BP=215nt
GAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCT
CCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTG
GATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTC
ATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCAT
ACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGT
AAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGTGT
GCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACCTG
ACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACAGG
GACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCATAG
ATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGACC

>43107_43107_12_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000347619_NLRP4_chr19_56388361_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_13_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000391806_NLRP4_chr19_56388361_ENST00000301295_length(transcript)=874nt_BP=151nt
AGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGC
CCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTG
GCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGC
AGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGG
ATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCT
GTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGG
CTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTC
TGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTG
TGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTT

>43107_43107_13_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000391806_NLRP4_chr19_56388361_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_14_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000391806_NLRP4_chr19_56388361_ENST00000346986_length(transcript)=876nt_BP=151nt
AGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGC
CCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTG
GCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGC
AGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGG
ATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCT
GTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGG
CTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTC
TGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTG
TGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTT

>43107_43107_14_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000391806_NLRP4_chr19_56388361_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_15_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000391806_NLRP4_chr19_56388361_ENST00000587891_length(transcript)=878nt_BP=151nt
AGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGC
CCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTG
GCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGC
AGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGG
ATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCT
GTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGG
CTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTC
TGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTG
TGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTT

>43107_43107_15_KLK8-NLRP4_KLK8_chr19_51504353_ENST00000391806_NLRP4_chr19_56388361_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_16_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000291726_NLRP4_chr19_56388362_ENST00000301295_length(transcript)=972nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_16_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000291726_NLRP4_chr19_56388362_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_17_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000291726_NLRP4_chr19_56388362_ENST00000346986_length(transcript)=974nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_17_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000291726_NLRP4_chr19_56388362_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_18_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000291726_NLRP4_chr19_56388362_ENST00000587891_length(transcript)=976nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_18_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000291726_NLRP4_chr19_56388362_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_19_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000320838_NLRP4_chr19_56388362_ENST00000301295_length(transcript)=972nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_19_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000320838_NLRP4_chr19_56388362_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_20_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000320838_NLRP4_chr19_56388362_ENST00000346986_length(transcript)=974nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_20_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000320838_NLRP4_chr19_56388362_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_21_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000320838_NLRP4_chr19_56388362_ENST00000587891_length(transcript)=976nt_BP=249nt
GTTCCCAGAAGCTCCCCAGGCTCTAGTGCAGGAGGAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTG
TACCAGGCAGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCA
TGGGACGCCCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCAC
TGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGT
GGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTG
CTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGT
TGTACTCTGTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACT
TCTGACGGCTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAAC
CTGGGCTCTGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACT
CTGAGTTGTGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGA

>43107_43107_21_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000320838_NLRP4_chr19_56388362_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_22_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000347619_NLRP4_chr19_56388362_ENST00000301295_length(transcript)=938nt_BP=215nt
GAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCT
CCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTG
GATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTC
ATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCAT
ACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGT
AAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGTGT
GCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACCTG
ACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACAGG
GACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCATAG
ATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGACC

>43107_43107_22_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000347619_NLRP4_chr19_56388362_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_23_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000347619_NLRP4_chr19_56388362_ENST00000346986_length(transcript)=940nt_BP=215nt
GAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCT
CCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTG
GATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTC
ATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCAT
ACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGT
AAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGTGT
GCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACCTG
ACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACAGG
GACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCATAG
ATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGACC

>43107_43107_23_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000347619_NLRP4_chr19_56388362_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_24_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000347619_NLRP4_chr19_56388362_ENST00000587891_length(transcript)=942nt_BP=215nt
GAGAAGGAGGAGGAGCAGGAGGTGGAGATTCCCAGTTAAAAGGCTCCAGAATCGTGTACCAGGCAGAGAACTGAAGTACTGGGGCCTCCT
CCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGCCCCCGACCTCGTGCGGCCAAGACGTG
GATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTGGCTGTGAAGACCTCGCCTCTGCTCTC
ATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGCAGCTGTTGTGTCGGGCTCTGACGCAT
ACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGGATCTCGCGTCTGTTCTCACCTGCAGT
AAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCTGTGAGGCCCTGAGACACCCAGAGTGT
GCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGGCTGAGGAAGAGAGAAATCCTAACCTG
ACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTCTGACTCGAACACCTGCAAAGGACAGG
GACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTGTGAGATTTCTGGCACCCCATTCATAG
ATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTTCATGGTCTCTCGGTCTCACAAGGACC

>43107_43107_24_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000347619_NLRP4_chr19_56388362_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_25_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000391806_NLRP4_chr19_56388362_ENST00000301295_length(transcript)=874nt_BP=151nt
AGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGC
CCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTG
GCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGC
AGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGG
ATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCT
GTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGG
CTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTC
TGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTG
TGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTT

>43107_43107_25_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000391806_NLRP4_chr19_56388362_ENST00000301295_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_26_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000391806_NLRP4_chr19_56388362_ENST00000346986_length(transcript)=876nt_BP=151nt
AGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGC
CCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTG
GCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGC
AGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGG
ATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCT
GTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGG
CTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTC
TGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTG
TGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTT

>43107_43107_26_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000391806_NLRP4_chr19_56388362_ENST00000346986_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

--------------------------------------------------------------
>43107_43107_27_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000391806_NLRP4_chr19_56388362_ENST00000587891_length(transcript)=878nt_BP=151nt
AGAGAACTGAAGTACTGGGGCCTCCTCCACTGGGTCCGAATCAGTAGGTGACCCCGCCCCTGGATTCTGGAAGACCTCACCATGGGACGC
CCCCGACCTCGTGCGGCCAAGACGTGGATGTTCCTGCTCTTGCTGGGGGGAGCCTGGGCAGTTTGGTAAAATGTTTTATCACTGCTGCTG
GCTGTGAAGACCTCGCCTCTGCTCTCATCAGCAATCAAAACCTGAAGATTCTGCAAATTGGGTGCAATGAAATCGGAGATGTGGGTGTGC
AGCTGTTGTGTCGGGCTCTGACGCATACGGATTGCCGCTTAGAGATTCTTGGGTTGGAAGAATGTGGGTTAACGAGCACCTGCTGTAAGG
ATCTCGCGTCTGTTCTCACCTGCAGTAAGACCCTGCAGCAGCTCAACCTGACCTTGAACACCTTGGACCACACAGGGGTGGTTGTACTCT
GTGAGGCCCTGAGACACCCAGAGTGTGCCCTGCAGGTGCTCGGGCTGAGAAAAACTGATTTTGATGAGGAAACCCAGGCACTTCTGACGG
CTGAGGAAGAGAGAAATCCTAACCTGACCATCACAGACGACTGTGACACAATCACAAGGGTAGAGATCTGATTGCGAGGAACCTGGGCTC
TGACTCGAACACCTGCAAAGGACAGGGACTGGGACCGTTACTTACATGACACTGCACCCAGGAGATACAAATCATTGATACTCTGAGTTG
TGAGATTTCTGGCACCCCATTCATAGATTTGATATGATACACGTGGTTTTTATGTGCTCTGTGGCCTTGGATGAGTCACTGAAAGGCCTT

>43107_43107_27_KLK8-NLRP4_KLK8_chr19_51504354_ENST00000391806_NLRP4_chr19_56388362_ENST00000587891_length(amino acids)=183AA_BP=28
MDSGRPHHGTPPTSCGQDVDVPALAGGSLGSLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLE
ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCDTITR

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Fusion Gene PPI Analysis for KLK8-NLRP4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for KLK8-NLRP4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KLK8-NLRP4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source