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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2B-CEACAM16 (FusionGDB2 ID:43227)

Fusion Gene Summary for KMT2B-CEACAM16

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2B-CEACAM16
Fusion gene ID: 43227
HgeneTgene
Gene symbol

KMT2B

CEACAM16

Gene ID

9757

388551

Gene namelysine methyltransferase 2BCEA cell adhesion molecule 16, tectorial membrane component
SynonymsCXXC10|DYT28|HRX2|MLL1B|MLL2|MLL4|TRX2|WBP-7|WBP7CEAL2|DFNA4B|DFNB113
Cytomap

19q13.12

19q13.31-q13.32

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2BWW domain binding protein 7histone-lysine N-methyltransferase MLL4lysine (K)-specific methyltransferase 2Bmixed lineage leukemia gene homolog 2myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophcarcinoembryonic antigen-related cell adhesion molecule 16carcinoembryonic antigen like-2 proteincarcinoembryonic antigen related cell adhesion molecule 16
Modification date2020031320200313
UniProtAcc

Q9UMN6

.
Ensembl transtripts involved in fusion geneENST00000607650, ENST00000222270, 
ENST00000420124, ENST00000341701, 
ENST00000405314, ENST00000587331, 
Fusion gene scores* DoF score6 X 6 X 4=1446 X 5 X 6=180
# samples 57
** MAII scorelog2(5/144*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2B [Title/Abstract] AND CEACAM16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2B(36228164)-CEACAM16(45213768), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2B

GO:0044648

histone H3-K4 dimethylation

25561738

HgeneKMT2B

GO:0097692

histone H3-K4 monomethylation

25561738


check buttonFusion gene breakpoints across KMT2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEACAM16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-4488-01AKMT2Bchr19

36228164

+CEACAM16chr19

45213768

+


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Fusion Gene ORF analysis for KMT2B-CEACAM16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000607650ENST00000405314KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
3UTR-3CDSENST00000607650ENST00000587331KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
In-frameENST00000222270ENST00000405314KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
In-frameENST00000222270ENST00000587331KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
In-frameENST00000420124ENST00000405314KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
In-frameENST00000420124ENST00000587331KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
intron-3CDSENST00000341701ENST00000405314KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+
intron-3CDSENST00000341701ENST00000587331KMT2Bchr19

36228164

+CEACAM16chr19

45213768

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222270KMT2Bchr1936228164+ENST00000587331CEACAM16chr1945213768+77697550075682522
ENST00000222270KMT2Bchr1936228164+ENST00000405314CEACAM16chr1945213768+77697550075682522
ENST00000420124KMT2Bchr1936228164+ENST00000587331CEACAM16chr1945213768+77697550075682522
ENST00000420124KMT2Bchr1936228164+ENST00000405314CEACAM16chr1945213768+77697550075682522

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222270ENST00000587331KMT2Bchr1936228164+CEACAM16chr1945213768+0.0052802120.99471974
ENST00000222270ENST00000405314KMT2Bchr1936228164+CEACAM16chr1945213768+0.0052802120.99471974
ENST00000420124ENST00000587331KMT2Bchr1936228164+CEACAM16chr1945213768+0.0052802120.99471974
ENST00000420124ENST00000405314KMT2Bchr1936228164+CEACAM16chr1945213768+0.0052802120.99471974

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Fusion Genomic Features for KMT2B-CEACAM16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KMT2Bchr1936228164+CEACAM16chr1945213767+0.0113414480.9886586
KMT2Bchr1936228164+CEACAM16chr1945213767+0.0113414480.9886586

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KMT2B-CEACAM16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:36228164/chr19:45213768)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2B

Q9UMN6

.
FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:17707229). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:17707229). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PubMed:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). {ECO:0000250|UniProtKB:O08550, ECO:0000269|PubMed:17707229}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371963_197025162716.0Compositional biasNote=Poly-Pro
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33372251_225925162716.0Compositional biasNote=Poly-Pro
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337248_25525162716.0Compositional biasNote=Poly-Pro
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+333726_3725162716.0Compositional biasNote=Poly-Gly
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337362_39825162716.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337402_77125162716.0Compositional biasNote=Pro-rich
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337808_81225162716.0Compositional biasNote=Poly-Gln
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371963_197025162716.0Compositional biasNote=Poly-Pro
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33372251_225925162716.0Compositional biasNote=Poly-Pro
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337248_25525162716.0Compositional biasNote=Poly-Pro
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+333726_3725162716.0Compositional biasNote=Poly-Gly
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337362_39825162716.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337402_77125162716.0Compositional biasNote=Pro-rich
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337808_81225162716.0Compositional biasNote=Poly-Gln
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337110_11725162716.0DNA bindingNote=A.T hook 2
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337357_36525162716.0DNA bindingNote=A.T hook 3
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+333737_4425162716.0DNA bindingNote=A.T hook 1
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337110_11725162716.0DNA bindingNote=A.T hook 2
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337357_36525162716.0DNA bindingNote=A.T hook 3
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+333737_4425162716.0DNA bindingNote=A.T hook 1
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371727_178325162716.0DomainFYR N-terminal
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33372411_249225162716.0DomainFYR C-terminal
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371727_178325162716.0DomainFYR N-terminal
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33372411_249225162716.0DomainFYR C-terminal
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+333717_3625162716.0MotifMenin-binding motif (MBM)
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+333717_3625162716.0MotifMenin-binding motif (MBM)
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371201_125225162716.0Zinc fingerPHD-type 1
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371249_130325162716.0Zinc fingerPHD-type 2
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371335_139625162716.0Zinc fingerPHD-type 3
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371578_161825162716.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33371639_168625162716.0Zinc fingerPHD-type 4
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+3337959_100625162716.0Zinc fingerCXXC-type
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371201_125225162716.0Zinc fingerPHD-type 1
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371249_130325162716.0Zinc fingerPHD-type 2
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371335_139625162716.0Zinc fingerPHD-type 3
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371578_161825162716.0Zinc fingerC2HC pre-PHD-type
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33371639_168625162716.0Zinc fingerPHD-type 4
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+3337959_100625162716.0Zinc fingerCXXC-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33372575_269125162716.0DomainSET
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33372699_271525162716.0DomainPost-SET
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33372575_269125162716.0DomainSET
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33372699_271525162716.0DomainPost-SET
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000222270+33372652_265325162716.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Bchr19:36228164chr19:45213768ENST00000420124+33372652_265325162716.0RegionS-adenosyl-L-methionine binding
TgeneCEACAM16chr19:36228164chr19:45213768ENST0000040531446133_218422426.0DomainNote=Ig-like C2-type 1
TgeneCEACAM16chr19:36228164chr19:45213768ENST0000040531446223_309422426.0DomainNote=Ig-like C2-type 2
TgeneCEACAM16chr19:36228164chr19:45213768ENST0000058733157133_218422426.0DomainNote=Ig-like C2-type 1
TgeneCEACAM16chr19:36228164chr19:45213768ENST0000058733157223_309422426.0DomainNote=Ig-like C2-type 2


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Fusion Gene Sequence for KMT2B-CEACAM16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43227_43227_1_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000222270_CEACAM16_chr19_45213768_ENST00000405314_length(transcript)=7769nt_BP=7550nt
ATGGCGGCGGCGGCGGGCGGCGGCAGTTGCCCCGGGCCTGGCTCCGCGCGGGGCCGCTTCCCGGGCCGGCCGCGGGGCGCCGGCGGGGGC
GGGGGCCGCGGCGGACGGGGCAACGGGGCCGAAAGAGTGCGGGTAGCTCTGCGGCGCGGCGGTGGCGCGACGGGGCCGGGCGGAGCCGAG
CCCGGGGAGGACACGGCCCTGCTCCGTTTGCTGGGGCTCCGCCGGGGCCTGCGCCGGCTCCGCCGCCTGTGGGCCGGCCCGCGGGTCCAG
CGGGGCCGGGGACGGGGTCGGGGCCGGGGCTGGGGCCCGAGTCGAGGCTGCGTGCCGGAGGAGGAGAGCAGTGACGGGGAATCCGACGAG
GAGGAGTTTCAGGGTTTTCATTCAGATGAAGATGTGGCCCCCAGTTCCCTGCGCTCTGCGCTCCGATCCCAGCGAGGTCGAGCGCCCCGA
GGTCGGGGTCGCAAGCATAAGACGACCCCCCTTCCTCCTCCTCGCCTAGCAGATGTGGCTCCTACCCCCCCAAAGACCCCTGCCCGGAAA
CGGGGTGAGGAAGGCACAGAACGGATGGTGCAGGCACTGACTGAACTTCTCCGGCGGGCCCAGGCACCCCAAGCACCCCGGAGCCGGGCA
TGTGAGCCCTCCACCCCCCGGCGGTCTCGGGGACGGCCCCCAGGACGGCCAGCAGGCCCCTGCAGGAGGAAGCAGCAAGCAGTAGTGGTG
GCAGAAGCAGCTGTGACAATCCCCAAACCTGAGCCCCCACCTCCTGTGGTTCCAGTGAAACATCAGACTGGCAGCTGGAAATGCAAGGAG
GGGCCCGGTCCAGGACCTGGGACCCCCAGGCGTGGAGGACAGTCAAGCCGTGGAGGCCGTGGAGGCAGGGGCCGCGGCCGAGGTGGTGGG
CTCCCCTTTGTGATCAAGTTTGTTTCAAGGGCCAAAAAAGTAAAGATGGGACAATTGTCCTTGGGACTCGAATCAGGTCAAGGTCAAGGT
CAACATGAGGAAAGTTGGCAGGATGTCCCCCAAAGAAGAGTTGGATCTGGACAGGGAGGGAGCCCTTGCTGGAAAAAGCAGGAACAGAAG
CTGGATGACGAGGAAGAAGAGAAGAAAGAAGAAGAAGAAAAAGACAAGGAGGGAGAAGAGAAGGAAGAAAGAGCTGTAGCTGAGGAGATG
ATGCCAGCTGCGGAAAAGGAAGAGGCAAAGCTGCCACCACCGCCTCTGACTCCTCCAGCCCCTTCACCTCCTCCACCCCTCCCACCCCCT
TCGACATCTCCTCCACCCCCACTCTGCCCTCCACCACCACCCCCAGTGTCCCCACCACCTCTACCATCCCCTCCACCGCCTCCTGCCCAA
GAGGAGCAGGAGGAATCCCCTCCTCCTGTGGTCCCAGCTACGTGCTCCAGGAAGAGGGGCCGGCCTCCCCTGACTCCCAGCCAGCGGGCG
GAGCGGGAAGCTGCTCGGGCAGGGCCAGAGGGCACCTCTCCTCCCACTCCAACCCCCAGCACCGCCACGGGAGGCCCTCCGGAAGACAGT
CCCACCGTGGCCCCCAAAAGCACCACCTTCCTGAAGAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATC
AAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCAAAGGTGGAGGTCTCACCTGTCCTGCGACCTCCCATTACCACCTCC
CCACCTGTTCCCCAGGAGCCAGCACCAGTCCCCTCTCCACCACGTGCCCCAACTCCTCCATCTACCCCAGTTCCACTCCCTGAGAAGAGA
CGGTCCATCCTAAGGGAACCCACATTTCGCTGGACCTCACTGACCCGGGAGCTGCCCCCTCCTCCCCCAGCCCCTCCACCTCCCCCGGCC
CCCTCCCCACCCCCTGCTCCTGCCACCTCCTCCCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAG
ATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAGCCTCCTCCTGCCGATGACTCTCCAGCTGAG
CCTGAGCCTCGGGCAGTGGGCCGCACCAACCACCTCAGCCTGCCTCGATTCGCCCCTGTGGTCACCACTCCTGTTAAGGCCGAGGTGTCC
CCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCCCTGCAGGCCTTGCAAACCCAGCTCCTGCCC
CAGGCACTACCGCCACCACAGCCACAGCTGCAGCCACCGCCGTCACCACAGCAGATGCCTCCCCTGGAAAAAGCCCGGATTGCGGGCGTG
GGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAG
CAGCAGAAGGTGGCAGCTTCCATGCCGCTGAGCCCTGGAGGGCAGATGGAGGAGGTGGCCGGGGCTGTCAAGCAGATCTCCGACAGAGGC
CCTGTCCGGTCTGAAGATGAGTCGGTGGAAGCTAAGAGAGAGCGGCCCTCAGGTCCCGAGTCCCCTGTGCAAGGTCCCCGCATCAAACAT
GTCTGCCGTCATGCTGCTGTGGCCCTGGGTCAGGCCCGGGCCATGGTGCCTGAAGATGTCCCTCGCCTCAGTGCCCTCCCTCTCCGGGAT
CGGCAGGACCTCGCCACAGAGGATACATCATCGGCGTCCGAGACTGAGAGTGTCCCGTCACGGTCCCGGCGGGGAAAGGTGGAGGCAGCA
GGCCCTGGGGGAGAATCAGAGCCCACAGGTTCTGGAGGGACCCTGGCCCACACACCCCGGCGCTCACTGCCCTCCCATCACGGCAAGAAG
ATGCGCATGGCTCGATGTGGACACTGTCGGGGCTGCCTACGTGTGCAGGACTGTGGGTCCTGTGTCAACTGCCTAGACAAGCCCAAGTTT
GGGGGCCCTAACACCAAGAAGCAGTGCTGTGTATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAGGC
CGGACGATAGTGAAGACGCTGTTGCCCTGGGATTCCGATGAATCTCCTGAGGCCTCCCCTGGTCCTCCAGGCCCACGCCGGGGGGCGGGA
GCTGGGGGGCCCCGGGAGGAGGTGGTGGCCCACCCAGGGCCCGAGGAGCAGGACTCCCTCCTGCAGCGCAAGTCAGCTCGGCGCTGCGTC
AAACAGCGACCCTCCTATGATATCTTCGAGGATTCGGATGACTCGGAGCCCGGGGGCCCCCCTGCTCCTCGGCGTCGGACCCCCCGAGAA
AATGAGCTGCCACTGCCAGAACCTGAGGAGCAGAGCCGGCCCCGCAAACCTACCCTGCAGCCTGTGTTGCAGCTCAAGGCCCGAAGGCGC
CTGGACAAGGATGCTTTGGCCCCTGGCCCCTTTGCTTCTTTTCCCAATGGCTGGACTGGAAAGCAGAAGTCTCCCGATGGTGTGCACCGC
GTCCGTGTGGATTTTAAGGAGGATTGTGATTTAGAGAACGTGTGGCTGATGGGGGGCCTGAGTGTGCTCACCTCTGTGCCAGGGGGCCCC
CCGATGGTGTGCTTGCTGTGTGCCAGCAAAGGACTCCACGAGCTGGTGTTCTGTCAAGTCTGCTGTGACCCATTCCACCCATTCTGCCTG
GAGGAGGCCGAGCGGCCCCTGCCCCAGCATCACGACACCTGGTGCTGCCGTCGCTGCAAATTCTGCCACGTCTGTGGACGCAAAGGTCGT
GGATCCAAGCACCTCCTGGAGTGCGAGCGCTGCCGCCATGCATACCACCCGGCCTGTCTGGGGCCCAGCTATCCAACCCGGGCCACGCGC
AAACGGCGCCACTGGATCTGTTCAGCCTGTGTGCGCTGTAAGAGCTGTGGGGCAACTCCAGGCAAGAACTGGGACGTCGAGTGGTCTGGA
GATTACAGCCTCTGCCCCAGGTGCACCCAGCTATATGAGAAAGGAAACTACTGCCCGATCTGTACACGCTGCTATGAAGACAACGACTAT
GAGAGCAAGATGATGCAGTGCGCACAGTGCGATCACTGGGTGCATGCCAAGTGCGAGGGGCTCTCAGATGAAGACTACGAGATCCTTTCA
GGACTGCCAGACTCGGTGCTGTACACCTGCGGACCGTGTGCTGGGGCAGCGCAGCCCCGCTGGCGAGAGGCCCTGAGCGGGGCCCTCCAG
GGGGGCCTGCGCCAGGTGCTCCAGGGCCTGCTGAGCTCCAAGGTGGTGGGCCCACTGCTGCTCTGCACCCAGTGTGGGCCAGATGGGAAG
CAACTGCACCCAGGACCCTGCGGCCTGCAAGCTGTGAGTCAGCGCTTCGAGGATGGCCACTACAAGTCTGTGCACAGCTTCATGGAGGAC
ATGGTGGGCATCCTCATGCGGCACTCGGAGGAGGGAGAGACCCCGGACCGCCGGGCTGGAGGCCAGATGAAGGGGCTCCTGCTGAAGCTG
CTAGAATCTGCGTTCGGCTGGTTCGACGCCCACGACCCCAAGTACTGGCGACGGAGTACCCGGCTGCCAAACGGAGTCCTTCCCAATGCG
GTGTTGCCCCCATCCCTGGATCATGTCTATGCGCAGTGGAGACAGCAGGAACCAGAGACCCCAGAATCAGGGCAGCCTCCAGGGGATCCC
TCAGCAGCATTCCAGGGCAAGGATCCGGCTGCCTTCTCACACCTGGAGGACCCCCGTCAGTGTGCACTCTGCCTCAAATACGGGGATGCA
GACTCCAAGGAGGCGGGGCGGCTCTTGTACATCGGGCAGAACGAGTGGACACACGTCAACTGTGCCATCTGGTCGGCGGAAGTCTTCGAG
GAGAACGACGGCTCCCTCAAGAATGTGCATGCTGCTGTGGCCCGAGGGAGGCAGATGCGCTGCGAGCTCTGCCTGAAGCCTGGCGCCACG
GTGGGCTGCTGCCTGTCCTCCTGCCTCAGCAACTTCCACTTCATGTGTGCCCGGGCCAGCTACTGCATCTTCCAGGATGACAAGAAAGTC
TTCTGCCAGAAACACACTGATCTCCTGGATGGCAAGGAAATTGTGAACCCCGATGGTTTTGATGTTCTCCGCCGAGTCTATGTGGACTTC
GAGGGCATCAACTTCAAGCGGAAGTTCTTGACGGGGCTTGAACCCGATGCCATCAACGTGCTCATTGGTTCCATCCGCATTGACTCCCTG
GGTACTCTGTCTGATCTCTCGGACTGCGAGGGACGGCTCTTCCCCATTGGCTACCAGTGCTCCCGTCTGTACTGGAGCACAGTGGATGCT
CGGAGGCGCTGCTGGTATCGGTGCCGAATTCTGGAGTATCGGCCATGGGGGCCGAGGGAAGAGCCAGCTCACCTGGAGGCTGCAGAGGAG
AACCAGACCATTGTGCACAGCCCCGCCCCTTCCTCAGAGCCCCCAGGTGGTGAGGACCCCCCACTGGACACAGATGTTCTTGTCCCTGGA
GCTCCTGAGCGCCACTCGCCCATTCAGAACCTGGACCCTCCACTGCGGCCAGATTCAGGCAGCGCCCCTCCTCCAGCCCCCCGTTCTTTT
TCGGGGGCTCGAATCAAAGTGCCCAACTACTCGCCATCCCGGAGGCCCTTGGGGGGTGTCTCCTTTGGCCCCCTGCCCTCCCCTGGAAGT
CCATCTTCACTGACCCACCACATCCCCACAGTGGGAGACCCGGACTTCCCAGCTCCCCCCAGACGTTCCCGTCGTCCCAGCCCTTTGGCT
CCCAGGCCGCCTCCATCACGGTGGGCCTCCCCTCCTCTAAAAACCTCCCCTCAGCTCAGGGTGCCCCCTCCTACCTCAGTCGTCACAGCC
CTCACACCTACCTCAGGGGAGCTGGCTCCCCCTGGCCCGGCCCCATCTCCACCACCCCCTGAAGACCTGGGCCCAGACTTCGAGGACATG
GAGGTGGTGTCAGGACTGAGTGCTGCTGACCTGGACTTCGCGGCCAGCCTGCTGGGGACTGAGCCCTTCCAGGAAGAGATTGTAGCCGCT
GGGGCCATGGGGAGCAGCCACGGGGGCCCGGGGGACAGCTCCGAGGAGGAGTCCAGCCCCACCTCCCGCTACATCCACTTCCCTGTGACT
GTGGTGTCCGCCCCTGGTCTGGCCCCCAGCGCTACCCCTGGAGCCCCCCGCATTGAACAGCTGGACGGCGTGGACGACGGCACTGACAGT
GAGGCTGAGGCGGTGCAGCAGCCTCGGGGCCAGGGCACGCCTCCTTCGGGGCCAGGAGTAGTCCGGGCAGGGGTCCTTGGGGCTGCAGGG
GACAGGGCCCGGCCTCCTGAGGACCTGCCATCGGAAATTGTGGATTTTGTGTTGAAGAACCTAGGGGGTCCTGGGGATGGAGGTGCTGGC
CCTAGAGAGGAGTCACTCCCCCCGGCGCCTCCCCTGGCTAATGGCAGCCAGCCCTCCCAAGGCCTGACCGCCAGCCCAGCTGACCCCACC
CGCACATTTGCCTGGCTCCCAGGGGCCCCAGGGGTCCGGGTGTTAAGCCTTGGCCCTGCCCCTGAGCCCCCCAAACCCGCCACATCCAAA
ATCATACTTGTCAACAAGCTGGGGCAAGTATTTGTGAAGATGGCTGGGGAGGGTGAACCTGTCCCACCCCCAGTGAAGCAGCCACCTTTG
CCCCCCACCATTTCCCCCACGGCTCCCACCTCCTGGACTCTGCCCCCAGGCCCCCTCCTCGGCGTGCTGCCCGTGGTCGGAGTGGTCCGC
CCTGCCCCGCCCCCGCCACCCCCTCCCCTGACGCTGGTGCTGAGCAGTGGGCCAGCCAGCCCGCCCCGCCAGGCCATCCGCGTCAAGAGG
GTGTCCACTTTCTCCGGCCGGTCCCCGCCAGCACCTCCCCCATACAAAGCCCCCCGGCTGGATGAAGATGGAGAGGCCTCAGAGGATACC
CCTCAGGTTCCAGGGCTTGGCAGTGGCGGGTTTAGCCGTGTGAGGATGAAAACCCCCACAGTGCGTGGGGTCCTTGACCTGGATCGGCCT
GGGGAGCCCGCTGGGGAAGAAAGTCCTGGGCCCCTCCAGGAACGGTCCCCTTTGCTGCCACTTCCGGAAGATGGTCCTCCCCAGGTCCCC
GATGGTCCCCCAGACCTGCTGCTTGAGTCCCAGTGGCACCACTATTCAGGTGAGGCTTCGAGCTCTGAGGAAGAGCCTCCATCCCCAGAT
GATAAAGAGAACCAGGCCCCAAAACGGACTGGCCCACATCTGCGCTTCGAGATCAGCAGTGAGGATGGGTTCAGCGTTGAGGCAGAGAGC
TTGGAGGGGGCGTGGAGAACTCTGATCGAGAAAGTGCAAGAGGCCCGAGGGCATGCCCGACTCAGACATCTCTCCTTTAGTGGAATGAGT
GGGGCGAGACTCCTGGGCATCCACCATGATGCTGTCATCTTCCTGGCCGAGCAGCTCCCCGGAGCCCAGCGTTGCCAGCACTATAAGTTC
CGTTACCACCAGCAGGGAGAGGGCCAGGAGGAGCCGCCCCTGAATCCCCATGGGGCTGCTCGGGCAGAGGTCTATCTCCGCCCTGGGGTA
ACAGCGTGACCCTGGAGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGC
GAGGATGCCAGGCTGTGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGA

>43227_43227_1_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000222270_CEACAM16_chr19_45213768_ENST00000405314_length(amino acids)=2522AA_BP=20
MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQ
RGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARK
RGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKE
GPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQK
LDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQ
EEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVI
KTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPA
PSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS
PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQ
QQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRD
RQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKF
GGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCV
KQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHR
VRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGR
GSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDY
ESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGK
QLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNA
VLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFE
ENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDF
EGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEE
NQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGS
PSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDM
EVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDS
EAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPT
RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVR
PAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRP
GEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAES
LEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRPGV

--------------------------------------------------------------
>43227_43227_2_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000222270_CEACAM16_chr19_45213768_ENST00000587331_length(transcript)=7769nt_BP=7550nt
ATGGCGGCGGCGGCGGGCGGCGGCAGTTGCCCCGGGCCTGGCTCCGCGCGGGGCCGCTTCCCGGGCCGGCCGCGGGGCGCCGGCGGGGGC
GGGGGCCGCGGCGGACGGGGCAACGGGGCCGAAAGAGTGCGGGTAGCTCTGCGGCGCGGCGGTGGCGCGACGGGGCCGGGCGGAGCCGAG
CCCGGGGAGGACACGGCCCTGCTCCGTTTGCTGGGGCTCCGCCGGGGCCTGCGCCGGCTCCGCCGCCTGTGGGCCGGCCCGCGGGTCCAG
CGGGGCCGGGGACGGGGTCGGGGCCGGGGCTGGGGCCCGAGTCGAGGCTGCGTGCCGGAGGAGGAGAGCAGTGACGGGGAATCCGACGAG
GAGGAGTTTCAGGGTTTTCATTCAGATGAAGATGTGGCCCCCAGTTCCCTGCGCTCTGCGCTCCGATCCCAGCGAGGTCGAGCGCCCCGA
GGTCGGGGTCGCAAGCATAAGACGACCCCCCTTCCTCCTCCTCGCCTAGCAGATGTGGCTCCTACCCCCCCAAAGACCCCTGCCCGGAAA
CGGGGTGAGGAAGGCACAGAACGGATGGTGCAGGCACTGACTGAACTTCTCCGGCGGGCCCAGGCACCCCAAGCACCCCGGAGCCGGGCA
TGTGAGCCCTCCACCCCCCGGCGGTCTCGGGGACGGCCCCCAGGACGGCCAGCAGGCCCCTGCAGGAGGAAGCAGCAAGCAGTAGTGGTG
GCAGAAGCAGCTGTGACAATCCCCAAACCTGAGCCCCCACCTCCTGTGGTTCCAGTGAAACATCAGACTGGCAGCTGGAAATGCAAGGAG
GGGCCCGGTCCAGGACCTGGGACCCCCAGGCGTGGAGGACAGTCAAGCCGTGGAGGCCGTGGAGGCAGGGGCCGCGGCCGAGGTGGTGGG
CTCCCCTTTGTGATCAAGTTTGTTTCAAGGGCCAAAAAAGTAAAGATGGGACAATTGTCCTTGGGACTCGAATCAGGTCAAGGTCAAGGT
CAACATGAGGAAAGTTGGCAGGATGTCCCCCAAAGAAGAGTTGGATCTGGACAGGGAGGGAGCCCTTGCTGGAAAAAGCAGGAACAGAAG
CTGGATGACGAGGAAGAAGAGAAGAAAGAAGAAGAAGAAAAAGACAAGGAGGGAGAAGAGAAGGAAGAAAGAGCTGTAGCTGAGGAGATG
ATGCCAGCTGCGGAAAAGGAAGAGGCAAAGCTGCCACCACCGCCTCTGACTCCTCCAGCCCCTTCACCTCCTCCACCCCTCCCACCCCCT
TCGACATCTCCTCCACCCCCACTCTGCCCTCCACCACCACCCCCAGTGTCCCCACCACCTCTACCATCCCCTCCACCGCCTCCTGCCCAA
GAGGAGCAGGAGGAATCCCCTCCTCCTGTGGTCCCAGCTACGTGCTCCAGGAAGAGGGGCCGGCCTCCCCTGACTCCCAGCCAGCGGGCG
GAGCGGGAAGCTGCTCGGGCAGGGCCAGAGGGCACCTCTCCTCCCACTCCAACCCCCAGCACCGCCACGGGAGGCCCTCCGGAAGACAGT
CCCACCGTGGCCCCCAAAAGCACCACCTTCCTGAAGAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATC
AAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCAAAGGTGGAGGTCTCACCTGTCCTGCGACCTCCCATTACCACCTCC
CCACCTGTTCCCCAGGAGCCAGCACCAGTCCCCTCTCCACCACGTGCCCCAACTCCTCCATCTACCCCAGTTCCACTCCCTGAGAAGAGA
CGGTCCATCCTAAGGGAACCCACATTTCGCTGGACCTCACTGACCCGGGAGCTGCCCCCTCCTCCCCCAGCCCCTCCACCTCCCCCGGCC
CCCTCCCCACCCCCTGCTCCTGCCACCTCCTCCCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAG
ATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAGCCTCCTCCTGCCGATGACTCTCCAGCTGAG
CCTGAGCCTCGGGCAGTGGGCCGCACCAACCACCTCAGCCTGCCTCGATTCGCCCCTGTGGTCACCACTCCTGTTAAGGCCGAGGTGTCC
CCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCCCTGCAGGCCTTGCAAACCCAGCTCCTGCCC
CAGGCACTACCGCCACCACAGCCACAGCTGCAGCCACCGCCGTCACCACAGCAGATGCCTCCCCTGGAAAAAGCCCGGATTGCGGGCGTG
GGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAG
CAGCAGAAGGTGGCAGCTTCCATGCCGCTGAGCCCTGGAGGGCAGATGGAGGAGGTGGCCGGGGCTGTCAAGCAGATCTCCGACAGAGGC
CCTGTCCGGTCTGAAGATGAGTCGGTGGAAGCTAAGAGAGAGCGGCCCTCAGGTCCCGAGTCCCCTGTGCAAGGTCCCCGCATCAAACAT
GTCTGCCGTCATGCTGCTGTGGCCCTGGGTCAGGCCCGGGCCATGGTGCCTGAAGATGTCCCTCGCCTCAGTGCCCTCCCTCTCCGGGAT
CGGCAGGACCTCGCCACAGAGGATACATCATCGGCGTCCGAGACTGAGAGTGTCCCGTCACGGTCCCGGCGGGGAAAGGTGGAGGCAGCA
GGCCCTGGGGGAGAATCAGAGCCCACAGGTTCTGGAGGGACCCTGGCCCACACACCCCGGCGCTCACTGCCCTCCCATCACGGCAAGAAG
ATGCGCATGGCTCGATGTGGACACTGTCGGGGCTGCCTACGTGTGCAGGACTGTGGGTCCTGTGTCAACTGCCTAGACAAGCCCAAGTTT
GGGGGCCCTAACACCAAGAAGCAGTGCTGTGTATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAGGC
CGGACGATAGTGAAGACGCTGTTGCCCTGGGATTCCGATGAATCTCCTGAGGCCTCCCCTGGTCCTCCAGGCCCACGCCGGGGGGCGGGA
GCTGGGGGGCCCCGGGAGGAGGTGGTGGCCCACCCAGGGCCCGAGGAGCAGGACTCCCTCCTGCAGCGCAAGTCAGCTCGGCGCTGCGTC
AAACAGCGACCCTCCTATGATATCTTCGAGGATTCGGATGACTCGGAGCCCGGGGGCCCCCCTGCTCCTCGGCGTCGGACCCCCCGAGAA
AATGAGCTGCCACTGCCAGAACCTGAGGAGCAGAGCCGGCCCCGCAAACCTACCCTGCAGCCTGTGTTGCAGCTCAAGGCCCGAAGGCGC
CTGGACAAGGATGCTTTGGCCCCTGGCCCCTTTGCTTCTTTTCCCAATGGCTGGACTGGAAAGCAGAAGTCTCCCGATGGTGTGCACCGC
GTCCGTGTGGATTTTAAGGAGGATTGTGATTTAGAGAACGTGTGGCTGATGGGGGGCCTGAGTGTGCTCACCTCTGTGCCAGGGGGCCCC
CCGATGGTGTGCTTGCTGTGTGCCAGCAAAGGACTCCACGAGCTGGTGTTCTGTCAAGTCTGCTGTGACCCATTCCACCCATTCTGCCTG
GAGGAGGCCGAGCGGCCCCTGCCCCAGCATCACGACACCTGGTGCTGCCGTCGCTGCAAATTCTGCCACGTCTGTGGACGCAAAGGTCGT
GGATCCAAGCACCTCCTGGAGTGCGAGCGCTGCCGCCATGCATACCACCCGGCCTGTCTGGGGCCCAGCTATCCAACCCGGGCCACGCGC
AAACGGCGCCACTGGATCTGTTCAGCCTGTGTGCGCTGTAAGAGCTGTGGGGCAACTCCAGGCAAGAACTGGGACGTCGAGTGGTCTGGA
GATTACAGCCTCTGCCCCAGGTGCACCCAGCTATATGAGAAAGGAAACTACTGCCCGATCTGTACACGCTGCTATGAAGACAACGACTAT
GAGAGCAAGATGATGCAGTGCGCACAGTGCGATCACTGGGTGCATGCCAAGTGCGAGGGGCTCTCAGATGAAGACTACGAGATCCTTTCA
GGACTGCCAGACTCGGTGCTGTACACCTGCGGACCGTGTGCTGGGGCAGCGCAGCCCCGCTGGCGAGAGGCCCTGAGCGGGGCCCTCCAG
GGGGGCCTGCGCCAGGTGCTCCAGGGCCTGCTGAGCTCCAAGGTGGTGGGCCCACTGCTGCTCTGCACCCAGTGTGGGCCAGATGGGAAG
CAACTGCACCCAGGACCCTGCGGCCTGCAAGCTGTGAGTCAGCGCTTCGAGGATGGCCACTACAAGTCTGTGCACAGCTTCATGGAGGAC
ATGGTGGGCATCCTCATGCGGCACTCGGAGGAGGGAGAGACCCCGGACCGCCGGGCTGGAGGCCAGATGAAGGGGCTCCTGCTGAAGCTG
CTAGAATCTGCGTTCGGCTGGTTCGACGCCCACGACCCCAAGTACTGGCGACGGAGTACCCGGCTGCCAAACGGAGTCCTTCCCAATGCG
GTGTTGCCCCCATCCCTGGATCATGTCTATGCGCAGTGGAGACAGCAGGAACCAGAGACCCCAGAATCAGGGCAGCCTCCAGGGGATCCC
TCAGCAGCATTCCAGGGCAAGGATCCGGCTGCCTTCTCACACCTGGAGGACCCCCGTCAGTGTGCACTCTGCCTCAAATACGGGGATGCA
GACTCCAAGGAGGCGGGGCGGCTCTTGTACATCGGGCAGAACGAGTGGACACACGTCAACTGTGCCATCTGGTCGGCGGAAGTCTTCGAG
GAGAACGACGGCTCCCTCAAGAATGTGCATGCTGCTGTGGCCCGAGGGAGGCAGATGCGCTGCGAGCTCTGCCTGAAGCCTGGCGCCACG
GTGGGCTGCTGCCTGTCCTCCTGCCTCAGCAACTTCCACTTCATGTGTGCCCGGGCCAGCTACTGCATCTTCCAGGATGACAAGAAAGTC
TTCTGCCAGAAACACACTGATCTCCTGGATGGCAAGGAAATTGTGAACCCCGATGGTTTTGATGTTCTCCGCCGAGTCTATGTGGACTTC
GAGGGCATCAACTTCAAGCGGAAGTTCTTGACGGGGCTTGAACCCGATGCCATCAACGTGCTCATTGGTTCCATCCGCATTGACTCCCTG
GGTACTCTGTCTGATCTCTCGGACTGCGAGGGACGGCTCTTCCCCATTGGCTACCAGTGCTCCCGTCTGTACTGGAGCACAGTGGATGCT
CGGAGGCGCTGCTGGTATCGGTGCCGAATTCTGGAGTATCGGCCATGGGGGCCGAGGGAAGAGCCAGCTCACCTGGAGGCTGCAGAGGAG
AACCAGACCATTGTGCACAGCCCCGCCCCTTCCTCAGAGCCCCCAGGTGGTGAGGACCCCCCACTGGACACAGATGTTCTTGTCCCTGGA
GCTCCTGAGCGCCACTCGCCCATTCAGAACCTGGACCCTCCACTGCGGCCAGATTCAGGCAGCGCCCCTCCTCCAGCCCCCCGTTCTTTT
TCGGGGGCTCGAATCAAAGTGCCCAACTACTCGCCATCCCGGAGGCCCTTGGGGGGTGTCTCCTTTGGCCCCCTGCCCTCCCCTGGAAGT
CCATCTTCACTGACCCACCACATCCCCACAGTGGGAGACCCGGACTTCCCAGCTCCCCCCAGACGTTCCCGTCGTCCCAGCCCTTTGGCT
CCCAGGCCGCCTCCATCACGGTGGGCCTCCCCTCCTCTAAAAACCTCCCCTCAGCTCAGGGTGCCCCCTCCTACCTCAGTCGTCACAGCC
CTCACACCTACCTCAGGGGAGCTGGCTCCCCCTGGCCCGGCCCCATCTCCACCACCCCCTGAAGACCTGGGCCCAGACTTCGAGGACATG
GAGGTGGTGTCAGGACTGAGTGCTGCTGACCTGGACTTCGCGGCCAGCCTGCTGGGGACTGAGCCCTTCCAGGAAGAGATTGTAGCCGCT
GGGGCCATGGGGAGCAGCCACGGGGGCCCGGGGGACAGCTCCGAGGAGGAGTCCAGCCCCACCTCCCGCTACATCCACTTCCCTGTGACT
GTGGTGTCCGCCCCTGGTCTGGCCCCCAGCGCTACCCCTGGAGCCCCCCGCATTGAACAGCTGGACGGCGTGGACGACGGCACTGACAGT
GAGGCTGAGGCGGTGCAGCAGCCTCGGGGCCAGGGCACGCCTCCTTCGGGGCCAGGAGTAGTCCGGGCAGGGGTCCTTGGGGCTGCAGGG
GACAGGGCCCGGCCTCCTGAGGACCTGCCATCGGAAATTGTGGATTTTGTGTTGAAGAACCTAGGGGGTCCTGGGGATGGAGGTGCTGGC
CCTAGAGAGGAGTCACTCCCCCCGGCGCCTCCCCTGGCTAATGGCAGCCAGCCCTCCCAAGGCCTGACCGCCAGCCCAGCTGACCCCACC
CGCACATTTGCCTGGCTCCCAGGGGCCCCAGGGGTCCGGGTGTTAAGCCTTGGCCCTGCCCCTGAGCCCCCCAAACCCGCCACATCCAAA
ATCATACTTGTCAACAAGCTGGGGCAAGTATTTGTGAAGATGGCTGGGGAGGGTGAACCTGTCCCACCCCCAGTGAAGCAGCCACCTTTG
CCCCCCACCATTTCCCCCACGGCTCCCACCTCCTGGACTCTGCCCCCAGGCCCCCTCCTCGGCGTGCTGCCCGTGGTCGGAGTGGTCCGC
CCTGCCCCGCCCCCGCCACCCCCTCCCCTGACGCTGGTGCTGAGCAGTGGGCCAGCCAGCCCGCCCCGCCAGGCCATCCGCGTCAAGAGG
GTGTCCACTTTCTCCGGCCGGTCCCCGCCAGCACCTCCCCCATACAAAGCCCCCCGGCTGGATGAAGATGGAGAGGCCTCAGAGGATACC
CCTCAGGTTCCAGGGCTTGGCAGTGGCGGGTTTAGCCGTGTGAGGATGAAAACCCCCACAGTGCGTGGGGTCCTTGACCTGGATCGGCCT
GGGGAGCCCGCTGGGGAAGAAAGTCCTGGGCCCCTCCAGGAACGGTCCCCTTTGCTGCCACTTCCGGAAGATGGTCCTCCCCAGGTCCCC
GATGGTCCCCCAGACCTGCTGCTTGAGTCCCAGTGGCACCACTATTCAGGTGAGGCTTCGAGCTCTGAGGAAGAGCCTCCATCCCCAGAT
GATAAAGAGAACCAGGCCCCAAAACGGACTGGCCCACATCTGCGCTTCGAGATCAGCAGTGAGGATGGGTTCAGCGTTGAGGCAGAGAGC
TTGGAGGGGGCGTGGAGAACTCTGATCGAGAAAGTGCAAGAGGCCCGAGGGCATGCCCGACTCAGACATCTCTCCTTTAGTGGAATGAGT
GGGGCGAGACTCCTGGGCATCCACCATGATGCTGTCATCTTCCTGGCCGAGCAGCTCCCCGGAGCCCAGCGTTGCCAGCACTATAAGTTC
CGTTACCACCAGCAGGGAGAGGGCCAGGAGGAGCCGCCCCTGAATCCCCATGGGGCTGCTCGGGCAGAGGTCTATCTCCGCCCTGGGGTA
ACAGCGTGACCCTGGAGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGC
GAGGATGCCAGGCTGTGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGA

>43227_43227_2_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000222270_CEACAM16_chr19_45213768_ENST00000587331_length(amino acids)=2522AA_BP=20
MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQ
RGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARK
RGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKE
GPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQK
LDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQ
EEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVI
KTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPA
PSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS
PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQ
QQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRD
RQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKF
GGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCV
KQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHR
VRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGR
GSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDY
ESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGK
QLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNA
VLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFE
ENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDF
EGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEE
NQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGS
PSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDM
EVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDS
EAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPT
RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVR
PAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRP
GEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAES
LEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRPGV

--------------------------------------------------------------
>43227_43227_3_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000420124_CEACAM16_chr19_45213768_ENST00000405314_length(transcript)=7769nt_BP=7550nt
ATGGCGGCGGCGGCGGGCGGCGGCAGTTGCCCCGGGCCTGGCTCCGCGCGGGGCCGCTTCCCGGGCCGGCCGCGGGGCGCCGGCGGGGGC
GGGGGCCGCGGCGGACGGGGCAACGGGGCCGAAAGAGTGCGGGTAGCTCTGCGGCGCGGCGGTGGCGCGACGGGGCCGGGCGGAGCCGAG
CCCGGGGAGGACACGGCCCTGCTCCGTTTGCTGGGGCTCCGCCGGGGCCTGCGCCGGCTCCGCCGCCTGTGGGCCGGCCCGCGGGTCCAG
CGGGGCCGGGGACGGGGTCGGGGCCGGGGCTGGGGCCCGAGTCGAGGCTGCGTGCCGGAGGAGGAGAGCAGTGACGGGGAATCCGACGAG
GAGGAGTTTCAGGGTTTTCATTCAGATGAAGATGTGGCCCCCAGTTCCCTGCGCTCTGCGCTCCGATCCCAGCGAGGTCGAGCGCCCCGA
GGTCGGGGTCGCAAGCATAAGACGACCCCCCTTCCTCCTCCTCGCCTAGCAGATGTGGCTCCTACCCCCCCAAAGACCCCTGCCCGGAAA
CGGGGTGAGGAAGGCACAGAACGGATGGTGCAGGCACTGACTGAACTTCTCCGGCGGGCCCAGGCACCCCAAGCACCCCGGAGCCGGGCA
TGTGAGCCCTCCACCCCCCGGCGGTCTCGGGGACGGCCCCCAGGACGGCCAGCAGGCCCCTGCAGGAGGAAGCAGCAAGCAGTAGTGGTG
GCAGAAGCAGCTGTGACAATCCCCAAACCTGAGCCCCCACCTCCTGTGGTTCCAGTGAAACATCAGACTGGCAGCTGGAAATGCAAGGAG
GGGCCCGGTCCAGGACCTGGGACCCCCAGGCGTGGAGGACAGTCAAGCCGTGGAGGCCGTGGAGGCAGGGGCCGCGGCCGAGGTGGTGGG
CTCCCCTTTGTGATCAAGTTTGTTTCAAGGGCCAAAAAAGTAAAGATGGGACAATTGTCCTTGGGACTCGAATCAGGTCAAGGTCAAGGT
CAACATGAGGAAAGTTGGCAGGATGTCCCCCAAAGAAGAGTTGGATCTGGACAGGGAGGGAGCCCTTGCTGGAAAAAGCAGGAACAGAAG
CTGGATGACGAGGAAGAAGAGAAGAAAGAAGAAGAAGAAAAAGACAAGGAGGGAGAAGAGAAGGAAGAAAGAGCTGTAGCTGAGGAGATG
ATGCCAGCTGCGGAAAAGGAAGAGGCAAAGCTGCCACCACCGCCTCTGACTCCTCCAGCCCCTTCACCTCCTCCACCCCTCCCACCCCCT
TCGACATCTCCTCCACCCCCACTCTGCCCTCCACCACCACCCCCAGTGTCCCCACCACCTCTACCATCCCCTCCACCGCCTCCTGCCCAA
GAGGAGCAGGAGGAATCCCCTCCTCCTGTGGTCCCAGCTACGTGCTCCAGGAAGAGGGGCCGGCCTCCCCTGACTCCCAGCCAGCGGGCG
GAGCGGGAAGCTGCTCGGGCAGGGCCAGAGGGCACCTCTCCTCCCACTCCAACCCCCAGCACCGCCACGGGAGGCCCTCCGGAAGACAGT
CCCACCGTGGCCCCCAAAAGCACCACCTTCCTGAAGAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATC
AAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCAAAGGTGGAGGTCTCACCTGTCCTGCGACCTCCCATTACCACCTCC
CCACCTGTTCCCCAGGAGCCAGCACCAGTCCCCTCTCCACCACGTGCCCCAACTCCTCCATCTACCCCAGTTCCACTCCCTGAGAAGAGA
CGGTCCATCCTAAGGGAACCCACATTTCGCTGGACCTCACTGACCCGGGAGCTGCCCCCTCCTCCCCCAGCCCCTCCACCTCCCCCGGCC
CCCTCCCCACCCCCTGCTCCTGCCACCTCCTCCCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAG
ATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAGCCTCCTCCTGCCGATGACTCTCCAGCTGAG
CCTGAGCCTCGGGCAGTGGGCCGCACCAACCACCTCAGCCTGCCTCGATTCGCCCCTGTGGTCACCACTCCTGTTAAGGCCGAGGTGTCC
CCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCCCTGCAGGCCTTGCAAACCCAGCTCCTGCCC
CAGGCACTACCGCCACCACAGCCACAGCTGCAGCCACCGCCGTCACCACAGCAGATGCCTCCCCTGGAAAAAGCCCGGATTGCGGGCGTG
GGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAG
CAGCAGAAGGTGGCAGCTTCCATGCCGCTGAGCCCTGGAGGGCAGATGGAGGAGGTGGCCGGGGCTGTCAAGCAGATCTCCGACAGAGGC
CCTGTCCGGTCTGAAGATGAGTCGGTGGAAGCTAAGAGAGAGCGGCCCTCAGGTCCCGAGTCCCCTGTGCAAGGTCCCCGCATCAAACAT
GTCTGCCGTCATGCTGCTGTGGCCCTGGGTCAGGCCCGGGCCATGGTGCCTGAAGATGTCCCTCGCCTCAGTGCCCTCCCTCTCCGGGAT
CGGCAGGACCTCGCCACAGAGGATACATCATCGGCGTCCGAGACTGAGAGTGTCCCGTCACGGTCCCGGCGGGGAAAGGTGGAGGCAGCA
GGCCCTGGGGGAGAATCAGAGCCCACAGGTTCTGGAGGGACCCTGGCCCACACACCCCGGCGCTCACTGCCCTCCCATCACGGCAAGAAG
ATGCGCATGGCTCGATGTGGACACTGTCGGGGCTGCCTACGTGTGCAGGACTGTGGGTCCTGTGTCAACTGCCTAGACAAGCCCAAGTTT
GGGGGCCCTAACACCAAGAAGCAGTGCTGTGTATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAGGC
CGGACGATAGTGAAGACGCTGTTGCCCTGGGATTCCGATGAATCTCCTGAGGCCTCCCCTGGTCCTCCAGGCCCACGCCGGGGGGCGGGA
GCTGGGGGGCCCCGGGAGGAGGTGGTGGCCCACCCAGGGCCCGAGGAGCAGGACTCCCTCCTGCAGCGCAAGTCAGCTCGGCGCTGCGTC
AAACAGCGACCCTCCTATGATATCTTCGAGGATTCGGATGACTCGGAGCCCGGGGGCCCCCCTGCTCCTCGGCGTCGGACCCCCCGAGAA
AATGAGCTGCCACTGCCAGAACCTGAGGAGCAGAGCCGGCCCCGCAAACCTACCCTGCAGCCTGTGTTGCAGCTCAAGGCCCGAAGGCGC
CTGGACAAGGATGCTTTGGCCCCTGGCCCCTTTGCTTCTTTTCCCAATGGCTGGACTGGAAAGCAGAAGTCTCCCGATGGTGTGCACCGC
GTCCGTGTGGATTTTAAGGAGGATTGTGATTTAGAGAACGTGTGGCTGATGGGGGGCCTGAGTGTGCTCACCTCTGTGCCAGGGGGCCCC
CCGATGGTGTGCTTGCTGTGTGCCAGCAAAGGACTCCACGAGCTGGTGTTCTGTCAAGTCTGCTGTGACCCATTCCACCCATTCTGCCTG
GAGGAGGCCGAGCGGCCCCTGCCCCAGCATCACGACACCTGGTGCTGCCGTCGCTGCAAATTCTGCCACGTCTGTGGACGCAAAGGTCGT
GGATCCAAGCACCTCCTGGAGTGCGAGCGCTGCCGCCATGCATACCACCCGGCCTGTCTGGGGCCCAGCTATCCAACCCGGGCCACGCGC
AAACGGCGCCACTGGATCTGTTCAGCCTGTGTGCGCTGTAAGAGCTGTGGGGCAACTCCAGGCAAGAACTGGGACGTCGAGTGGTCTGGA
GATTACAGCCTCTGCCCCAGGTGCACCCAGCTATATGAGAAAGGAAACTACTGCCCGATCTGTACACGCTGCTATGAAGACAACGACTAT
GAGAGCAAGATGATGCAGTGCGCACAGTGCGATCACTGGGTGCATGCCAAGTGCGAGGGGCTCTCAGATGAAGACTACGAGATCCTTTCA
GGACTGCCAGACTCGGTGCTGTACACCTGCGGACCGTGTGCTGGGGCAGCGCAGCCCCGCTGGCGAGAGGCCCTGAGCGGGGCCCTCCAG
GGGGGCCTGCGCCAGGTGCTCCAGGGCCTGCTGAGCTCCAAGGTGGTGGGCCCACTGCTGCTCTGCACCCAGTGTGGGCCAGATGGGAAG
CAACTGCACCCAGGACCCTGCGGCCTGCAAGCTGTGAGTCAGCGCTTCGAGGATGGCCACTACAAGTCTGTGCACAGCTTCATGGAGGAC
ATGGTGGGCATCCTCATGCGGCACTCGGAGGAGGGAGAGACCCCGGACCGCCGGGCTGGAGGCCAGATGAAGGGGCTCCTGCTGAAGCTG
CTAGAATCTGCGTTCGGCTGGTTCGACGCCCACGACCCCAAGTACTGGCGACGGAGTACCCGGCTGCCAAACGGAGTCCTTCCCAATGCG
GTGTTGCCCCCATCCCTGGATCATGTCTATGCGCAGTGGAGACAGCAGGAACCAGAGACCCCAGAATCAGGGCAGCCTCCAGGGGATCCC
TCAGCAGCATTCCAGGGCAAGGATCCGGCTGCCTTCTCACACCTGGAGGACCCCCGTCAGTGTGCACTCTGCCTCAAATACGGGGATGCA
GACTCCAAGGAGGCGGGGCGGCTCTTGTACATCGGGCAGAACGAGTGGACACACGTCAACTGTGCCATCTGGTCGGCGGAAGTCTTCGAG
GAGAACGACGGCTCCCTCAAGAATGTGCATGCTGCTGTGGCCCGAGGGAGGCAGATGCGCTGCGAGCTCTGCCTGAAGCCTGGCGCCACG
GTGGGCTGCTGCCTGTCCTCCTGCCTCAGCAACTTCCACTTCATGTGTGCCCGGGCCAGCTACTGCATCTTCCAGGATGACAAGAAAGTC
TTCTGCCAGAAACACACTGATCTCCTGGATGGCAAGGAAATTGTGAACCCCGATGGTTTTGATGTTCTCCGCCGAGTCTATGTGGACTTC
GAGGGCATCAACTTCAAGCGGAAGTTCTTGACGGGGCTTGAACCCGATGCCATCAACGTGCTCATTGGTTCCATCCGCATTGACTCCCTG
GGTACTCTGTCTGATCTCTCGGACTGCGAGGGACGGCTCTTCCCCATTGGCTACCAGTGCTCCCGTCTGTACTGGAGCACAGTGGATGCT
CGGAGGCGCTGCTGGTATCGGTGCCGAATTCTGGAGTATCGGCCATGGGGGCCGAGGGAAGAGCCAGCTCACCTGGAGGCTGCAGAGGAG
AACCAGACCATTGTGCACAGCCCCGCCCCTTCCTCAGAGCCCCCAGGTGGTGAGGACCCCCCACTGGACACAGATGTTCTTGTCCCTGGA
GCTCCTGAGCGCCACTCGCCCATTCAGAACCTGGACCCTCCACTGCGGCCAGATTCAGGCAGCGCCCCTCCTCCAGCCCCCCGTTCTTTT
TCGGGGGCTCGAATCAAAGTGCCCAACTACTCGCCATCCCGGAGGCCCTTGGGGGGTGTCTCCTTTGGCCCCCTGCCCTCCCCTGGAAGT
CCATCTTCACTGACCCACCACATCCCCACAGTGGGAGACCCGGACTTCCCAGCTCCCCCCAGACGTTCCCGTCGTCCCAGCCCTTTGGCT
CCCAGGCCGCCTCCATCACGGTGGGCCTCCCCTCCTCTAAAAACCTCCCCTCAGCTCAGGGTGCCCCCTCCTACCTCAGTCGTCACAGCC
CTCACACCTACCTCAGGGGAGCTGGCTCCCCCTGGCCCGGCCCCATCTCCACCACCCCCTGAAGACCTGGGCCCAGACTTCGAGGACATG
GAGGTGGTGTCAGGACTGAGTGCTGCTGACCTGGACTTCGCGGCCAGCCTGCTGGGGACTGAGCCCTTCCAGGAAGAGATTGTAGCCGCT
GGGGCCATGGGGAGCAGCCACGGGGGCCCGGGGGACAGCTCCGAGGAGGAGTCCAGCCCCACCTCCCGCTACATCCACTTCCCTGTGACT
GTGGTGTCCGCCCCTGGTCTGGCCCCCAGCGCTACCCCTGGAGCCCCCCGCATTGAACAGCTGGACGGCGTGGACGACGGCACTGACAGT
GAGGCTGAGGCGGTGCAGCAGCCTCGGGGCCAGGGCACGCCTCCTTCGGGGCCAGGAGTAGTCCGGGCAGGGGTCCTTGGGGCTGCAGGG
GACAGGGCCCGGCCTCCTGAGGACCTGCCATCGGAAATTGTGGATTTTGTGTTGAAGAACCTAGGGGGTCCTGGGGATGGAGGTGCTGGC
CCTAGAGAGGAGTCACTCCCCCCGGCGCCTCCCCTGGCTAATGGCAGCCAGCCCTCCCAAGGCCTGACCGCCAGCCCAGCTGACCCCACC
CGCACATTTGCCTGGCTCCCAGGGGCCCCAGGGGTCCGGGTGTTAAGCCTTGGCCCTGCCCCTGAGCCCCCCAAACCCGCCACATCCAAA
ATCATACTTGTCAACAAGCTGGGGCAAGTATTTGTGAAGATGGCTGGGGAGGGTGAACCTGTCCCACCCCCAGTGAAGCAGCCACCTTTG
CCCCCCACCATTTCCCCCACGGCTCCCACCTCCTGGACTCTGCCCCCAGGCCCCCTCCTCGGCGTGCTGCCCGTGGTCGGAGTGGTCCGC
CCTGCCCCGCCCCCGCCACCCCCTCCCCTGACGCTGGTGCTGAGCAGTGGGCCAGCCAGCCCGCCCCGCCAGGCCATCCGCGTCAAGAGG
GTGTCCACTTTCTCCGGCCGGTCCCCGCCAGCACCTCCCCCATACAAAGCCCCCCGGCTGGATGAAGATGGAGAGGCCTCAGAGGATACC
CCTCAGGTTCCAGGGCTTGGCAGTGGCGGGTTTAGCCGTGTGAGGATGAAAACCCCCACAGTGCGTGGGGTCCTTGACCTGGATCGGCCT
GGGGAGCCCGCTGGGGAAGAAAGTCCTGGGCCCCTCCAGGAACGGTCCCCTTTGCTGCCACTTCCGGAAGATGGTCCTCCCCAGGTCCCC
GATGGTCCCCCAGACCTGCTGCTTGAGTCCCAGTGGCACCACTATTCAGGTGAGGCTTCGAGCTCTGAGGAAGAGCCTCCATCCCCAGAT
GATAAAGAGAACCAGGCCCCAAAACGGACTGGCCCACATCTGCGCTTCGAGATCAGCAGTGAGGATGGGTTCAGCGTTGAGGCAGAGAGC
TTGGAGGGGGCGTGGAGAACTCTGATCGAGAAAGTGCAAGAGGCCCGAGGGCATGCCCGACTCAGACATCTCTCCTTTAGTGGAATGAGT
GGGGCGAGACTCCTGGGCATCCACCATGATGCTGTCATCTTCCTGGCCGAGCAGCTCCCCGGAGCCCAGCGTTGCCAGCACTATAAGTTC
CGTTACCACCAGCAGGGAGAGGGCCAGGAGGAGCCGCCCCTGAATCCCCATGGGGCTGCTCGGGCAGAGGTCTATCTCCGCCCTGGGGTA
ACAGCGTGACCCTGGAGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGC
GAGGATGCCAGGCTGTGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGA

>43227_43227_3_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000420124_CEACAM16_chr19_45213768_ENST00000405314_length(amino acids)=2522AA_BP=20
MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQ
RGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARK
RGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKE
GPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQK
LDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQ
EEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVI
KTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPA
PSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS
PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQ
QQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRD
RQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKF
GGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCV
KQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHR
VRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGR
GSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDY
ESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGK
QLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNA
VLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFE
ENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDF
EGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEE
NQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGS
PSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDM
EVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDS
EAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPT
RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVR
PAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRP
GEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAES
LEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRPGV

--------------------------------------------------------------
>43227_43227_4_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000420124_CEACAM16_chr19_45213768_ENST00000587331_length(transcript)=7769nt_BP=7550nt
ATGGCGGCGGCGGCGGGCGGCGGCAGTTGCCCCGGGCCTGGCTCCGCGCGGGGCCGCTTCCCGGGCCGGCCGCGGGGCGCCGGCGGGGGC
GGGGGCCGCGGCGGACGGGGCAACGGGGCCGAAAGAGTGCGGGTAGCTCTGCGGCGCGGCGGTGGCGCGACGGGGCCGGGCGGAGCCGAG
CCCGGGGAGGACACGGCCCTGCTCCGTTTGCTGGGGCTCCGCCGGGGCCTGCGCCGGCTCCGCCGCCTGTGGGCCGGCCCGCGGGTCCAG
CGGGGCCGGGGACGGGGTCGGGGCCGGGGCTGGGGCCCGAGTCGAGGCTGCGTGCCGGAGGAGGAGAGCAGTGACGGGGAATCCGACGAG
GAGGAGTTTCAGGGTTTTCATTCAGATGAAGATGTGGCCCCCAGTTCCCTGCGCTCTGCGCTCCGATCCCAGCGAGGTCGAGCGCCCCGA
GGTCGGGGTCGCAAGCATAAGACGACCCCCCTTCCTCCTCCTCGCCTAGCAGATGTGGCTCCTACCCCCCCAAAGACCCCTGCCCGGAAA
CGGGGTGAGGAAGGCACAGAACGGATGGTGCAGGCACTGACTGAACTTCTCCGGCGGGCCCAGGCACCCCAAGCACCCCGGAGCCGGGCA
TGTGAGCCCTCCACCCCCCGGCGGTCTCGGGGACGGCCCCCAGGACGGCCAGCAGGCCCCTGCAGGAGGAAGCAGCAAGCAGTAGTGGTG
GCAGAAGCAGCTGTGACAATCCCCAAACCTGAGCCCCCACCTCCTGTGGTTCCAGTGAAACATCAGACTGGCAGCTGGAAATGCAAGGAG
GGGCCCGGTCCAGGACCTGGGACCCCCAGGCGTGGAGGACAGTCAAGCCGTGGAGGCCGTGGAGGCAGGGGCCGCGGCCGAGGTGGTGGG
CTCCCCTTTGTGATCAAGTTTGTTTCAAGGGCCAAAAAAGTAAAGATGGGACAATTGTCCTTGGGACTCGAATCAGGTCAAGGTCAAGGT
CAACATGAGGAAAGTTGGCAGGATGTCCCCCAAAGAAGAGTTGGATCTGGACAGGGAGGGAGCCCTTGCTGGAAAAAGCAGGAACAGAAG
CTGGATGACGAGGAAGAAGAGAAGAAAGAAGAAGAAGAAAAAGACAAGGAGGGAGAAGAGAAGGAAGAAAGAGCTGTAGCTGAGGAGATG
ATGCCAGCTGCGGAAAAGGAAGAGGCAAAGCTGCCACCACCGCCTCTGACTCCTCCAGCCCCTTCACCTCCTCCACCCCTCCCACCCCCT
TCGACATCTCCTCCACCCCCACTCTGCCCTCCACCACCACCCCCAGTGTCCCCACCACCTCTACCATCCCCTCCACCGCCTCCTGCCCAA
GAGGAGCAGGAGGAATCCCCTCCTCCTGTGGTCCCAGCTACGTGCTCCAGGAAGAGGGGCCGGCCTCCCCTGACTCCCAGCCAGCGGGCG
GAGCGGGAAGCTGCTCGGGCAGGGCCAGAGGGCACCTCTCCTCCCACTCCAACCCCCAGCACCGCCACGGGAGGCCCTCCGGAAGACAGT
CCCACCGTGGCCCCCAAAAGCACCACCTTCCTGAAGAATATCCGGCAGTTTATTATGCCTGTGGTGAGTGCCCGCTCCTCCCGTGTCATC
AAGACACCCCGGCGATTTATGGATGAAGACCCCCCCAAACCCCCAAAGGTGGAGGTCTCACCTGTCCTGCGACCTCCCATTACCACCTCC
CCACCTGTTCCCCAGGAGCCAGCACCAGTCCCCTCTCCACCACGTGCCCCAACTCCTCCATCTACCCCAGTTCCACTCCCTGAGAAGAGA
CGGTCCATCCTAAGGGAACCCACATTTCGCTGGACCTCACTGACCCGGGAGCTGCCCCCTCCTCCCCCAGCCCCTCCACCTCCCCCGGCC
CCCTCCCCACCCCCTGCTCCTGCCACCTCCTCCCGGAGGCCCCTACTCCTTCGGGCCCCTCAGTTTACCCCAAGCGAAGCCCACCTGAAG
ATCTACGAATCGGTGCTTACTCCTCCTCCTCTTGGGGCTCCTGAAGCCCCTGAGCCAGAGCCTCCTCCTGCCGATGACTCTCCAGCTGAG
CCTGAGCCTCGGGCAGTGGGCCGCACCAACCACCTCAGCCTGCCTCGATTCGCCCCTGTGGTCACCACTCCTGTTAAGGCCGAGGTGTCC
CCTCACGGGGCTCCAGCTCTGAGCAACGGGCCACAGACACAGGCTCAGCTACTGCAGCCCCTGCAGGCCTTGCAAACCCAGCTCCTGCCC
CAGGCACTACCGCCACCACAGCCACAGCTGCAGCCACCGCCGTCACCACAGCAGATGCCTCCCCTGGAAAAAGCCCGGATTGCGGGCGTG
GGTTCCTTGCCGCTGTCTGGGGTAGAGGAGAAGATGTTCAGCCTCCTCAAGAGAGCCAAAGTGCAGCTATTCAAGATCGATCAGCAGCAG
CAGCAGAAGGTGGCAGCTTCCATGCCGCTGAGCCCTGGAGGGCAGATGGAGGAGGTGGCCGGGGCTGTCAAGCAGATCTCCGACAGAGGC
CCTGTCCGGTCTGAAGATGAGTCGGTGGAAGCTAAGAGAGAGCGGCCCTCAGGTCCCGAGTCCCCTGTGCAAGGTCCCCGCATCAAACAT
GTCTGCCGTCATGCTGCTGTGGCCCTGGGTCAGGCCCGGGCCATGGTGCCTGAAGATGTCCCTCGCCTCAGTGCCCTCCCTCTCCGGGAT
CGGCAGGACCTCGCCACAGAGGATACATCATCGGCGTCCGAGACTGAGAGTGTCCCGTCACGGTCCCGGCGGGGAAAGGTGGAGGCAGCA
GGCCCTGGGGGAGAATCAGAGCCCACAGGTTCTGGAGGGACCCTGGCCCACACACCCCGGCGCTCACTGCCCTCCCATCACGGCAAGAAG
ATGCGCATGGCTCGATGTGGACACTGTCGGGGCTGCCTACGTGTGCAGGACTGTGGGTCCTGTGTCAACTGCCTAGACAAGCCCAAGTTT
GGGGGCCCTAACACCAAGAAGCAGTGCTGTGTATACCGGAAGTGTGACAAAATAGAGGCTCGGAAGATGGAACGACTGGCTAAAAAAGGC
CGGACGATAGTGAAGACGCTGTTGCCCTGGGATTCCGATGAATCTCCTGAGGCCTCCCCTGGTCCTCCAGGCCCACGCCGGGGGGCGGGA
GCTGGGGGGCCCCGGGAGGAGGTGGTGGCCCACCCAGGGCCCGAGGAGCAGGACTCCCTCCTGCAGCGCAAGTCAGCTCGGCGCTGCGTC
AAACAGCGACCCTCCTATGATATCTTCGAGGATTCGGATGACTCGGAGCCCGGGGGCCCCCCTGCTCCTCGGCGTCGGACCCCCCGAGAA
AATGAGCTGCCACTGCCAGAACCTGAGGAGCAGAGCCGGCCCCGCAAACCTACCCTGCAGCCTGTGTTGCAGCTCAAGGCCCGAAGGCGC
CTGGACAAGGATGCTTTGGCCCCTGGCCCCTTTGCTTCTTTTCCCAATGGCTGGACTGGAAAGCAGAAGTCTCCCGATGGTGTGCACCGC
GTCCGTGTGGATTTTAAGGAGGATTGTGATTTAGAGAACGTGTGGCTGATGGGGGGCCTGAGTGTGCTCACCTCTGTGCCAGGGGGCCCC
CCGATGGTGTGCTTGCTGTGTGCCAGCAAAGGACTCCACGAGCTGGTGTTCTGTCAAGTCTGCTGTGACCCATTCCACCCATTCTGCCTG
GAGGAGGCCGAGCGGCCCCTGCCCCAGCATCACGACACCTGGTGCTGCCGTCGCTGCAAATTCTGCCACGTCTGTGGACGCAAAGGTCGT
GGATCCAAGCACCTCCTGGAGTGCGAGCGCTGCCGCCATGCATACCACCCGGCCTGTCTGGGGCCCAGCTATCCAACCCGGGCCACGCGC
AAACGGCGCCACTGGATCTGTTCAGCCTGTGTGCGCTGTAAGAGCTGTGGGGCAACTCCAGGCAAGAACTGGGACGTCGAGTGGTCTGGA
GATTACAGCCTCTGCCCCAGGTGCACCCAGCTATATGAGAAAGGAAACTACTGCCCGATCTGTACACGCTGCTATGAAGACAACGACTAT
GAGAGCAAGATGATGCAGTGCGCACAGTGCGATCACTGGGTGCATGCCAAGTGCGAGGGGCTCTCAGATGAAGACTACGAGATCCTTTCA
GGACTGCCAGACTCGGTGCTGTACACCTGCGGACCGTGTGCTGGGGCAGCGCAGCCCCGCTGGCGAGAGGCCCTGAGCGGGGCCCTCCAG
GGGGGCCTGCGCCAGGTGCTCCAGGGCCTGCTGAGCTCCAAGGTGGTGGGCCCACTGCTGCTCTGCACCCAGTGTGGGCCAGATGGGAAG
CAACTGCACCCAGGACCCTGCGGCCTGCAAGCTGTGAGTCAGCGCTTCGAGGATGGCCACTACAAGTCTGTGCACAGCTTCATGGAGGAC
ATGGTGGGCATCCTCATGCGGCACTCGGAGGAGGGAGAGACCCCGGACCGCCGGGCTGGAGGCCAGATGAAGGGGCTCCTGCTGAAGCTG
CTAGAATCTGCGTTCGGCTGGTTCGACGCCCACGACCCCAAGTACTGGCGACGGAGTACCCGGCTGCCAAACGGAGTCCTTCCCAATGCG
GTGTTGCCCCCATCCCTGGATCATGTCTATGCGCAGTGGAGACAGCAGGAACCAGAGACCCCAGAATCAGGGCAGCCTCCAGGGGATCCC
TCAGCAGCATTCCAGGGCAAGGATCCGGCTGCCTTCTCACACCTGGAGGACCCCCGTCAGTGTGCACTCTGCCTCAAATACGGGGATGCA
GACTCCAAGGAGGCGGGGCGGCTCTTGTACATCGGGCAGAACGAGTGGACACACGTCAACTGTGCCATCTGGTCGGCGGAAGTCTTCGAG
GAGAACGACGGCTCCCTCAAGAATGTGCATGCTGCTGTGGCCCGAGGGAGGCAGATGCGCTGCGAGCTCTGCCTGAAGCCTGGCGCCACG
GTGGGCTGCTGCCTGTCCTCCTGCCTCAGCAACTTCCACTTCATGTGTGCCCGGGCCAGCTACTGCATCTTCCAGGATGACAAGAAAGTC
TTCTGCCAGAAACACACTGATCTCCTGGATGGCAAGGAAATTGTGAACCCCGATGGTTTTGATGTTCTCCGCCGAGTCTATGTGGACTTC
GAGGGCATCAACTTCAAGCGGAAGTTCTTGACGGGGCTTGAACCCGATGCCATCAACGTGCTCATTGGTTCCATCCGCATTGACTCCCTG
GGTACTCTGTCTGATCTCTCGGACTGCGAGGGACGGCTCTTCCCCATTGGCTACCAGTGCTCCCGTCTGTACTGGAGCACAGTGGATGCT
CGGAGGCGCTGCTGGTATCGGTGCCGAATTCTGGAGTATCGGCCATGGGGGCCGAGGGAAGAGCCAGCTCACCTGGAGGCTGCAGAGGAG
AACCAGACCATTGTGCACAGCCCCGCCCCTTCCTCAGAGCCCCCAGGTGGTGAGGACCCCCCACTGGACACAGATGTTCTTGTCCCTGGA
GCTCCTGAGCGCCACTCGCCCATTCAGAACCTGGACCCTCCACTGCGGCCAGATTCAGGCAGCGCCCCTCCTCCAGCCCCCCGTTCTTTT
TCGGGGGCTCGAATCAAAGTGCCCAACTACTCGCCATCCCGGAGGCCCTTGGGGGGTGTCTCCTTTGGCCCCCTGCCCTCCCCTGGAAGT
CCATCTTCACTGACCCACCACATCCCCACAGTGGGAGACCCGGACTTCCCAGCTCCCCCCAGACGTTCCCGTCGTCCCAGCCCTTTGGCT
CCCAGGCCGCCTCCATCACGGTGGGCCTCCCCTCCTCTAAAAACCTCCCCTCAGCTCAGGGTGCCCCCTCCTACCTCAGTCGTCACAGCC
CTCACACCTACCTCAGGGGAGCTGGCTCCCCCTGGCCCGGCCCCATCTCCACCACCCCCTGAAGACCTGGGCCCAGACTTCGAGGACATG
GAGGTGGTGTCAGGACTGAGTGCTGCTGACCTGGACTTCGCGGCCAGCCTGCTGGGGACTGAGCCCTTCCAGGAAGAGATTGTAGCCGCT
GGGGCCATGGGGAGCAGCCACGGGGGCCCGGGGGACAGCTCCGAGGAGGAGTCCAGCCCCACCTCCCGCTACATCCACTTCCCTGTGACT
GTGGTGTCCGCCCCTGGTCTGGCCCCCAGCGCTACCCCTGGAGCCCCCCGCATTGAACAGCTGGACGGCGTGGACGACGGCACTGACAGT
GAGGCTGAGGCGGTGCAGCAGCCTCGGGGCCAGGGCACGCCTCCTTCGGGGCCAGGAGTAGTCCGGGCAGGGGTCCTTGGGGCTGCAGGG
GACAGGGCCCGGCCTCCTGAGGACCTGCCATCGGAAATTGTGGATTTTGTGTTGAAGAACCTAGGGGGTCCTGGGGATGGAGGTGCTGGC
CCTAGAGAGGAGTCACTCCCCCCGGCGCCTCCCCTGGCTAATGGCAGCCAGCCCTCCCAAGGCCTGACCGCCAGCCCAGCTGACCCCACC
CGCACATTTGCCTGGCTCCCAGGGGCCCCAGGGGTCCGGGTGTTAAGCCTTGGCCCTGCCCCTGAGCCCCCCAAACCCGCCACATCCAAA
ATCATACTTGTCAACAAGCTGGGGCAAGTATTTGTGAAGATGGCTGGGGAGGGTGAACCTGTCCCACCCCCAGTGAAGCAGCCACCTTTG
CCCCCCACCATTTCCCCCACGGCTCCCACCTCCTGGACTCTGCCCCCAGGCCCCCTCCTCGGCGTGCTGCCCGTGGTCGGAGTGGTCCGC
CCTGCCCCGCCCCCGCCACCCCCTCCCCTGACGCTGGTGCTGAGCAGTGGGCCAGCCAGCCCGCCCCGCCAGGCCATCCGCGTCAAGAGG
GTGTCCACTTTCTCCGGCCGGTCCCCGCCAGCACCTCCCCCATACAAAGCCCCCCGGCTGGATGAAGATGGAGAGGCCTCAGAGGATACC
CCTCAGGTTCCAGGGCTTGGCAGTGGCGGGTTTAGCCGTGTGAGGATGAAAACCCCCACAGTGCGTGGGGTCCTTGACCTGGATCGGCCT
GGGGAGCCCGCTGGGGAAGAAAGTCCTGGGCCCCTCCAGGAACGGTCCCCTTTGCTGCCACTTCCGGAAGATGGTCCTCCCCAGGTCCCC
GATGGTCCCCCAGACCTGCTGCTTGAGTCCCAGTGGCACCACTATTCAGGTGAGGCTTCGAGCTCTGAGGAAGAGCCTCCATCCCCAGAT
GATAAAGAGAACCAGGCCCCAAAACGGACTGGCCCACATCTGCGCTTCGAGATCAGCAGTGAGGATGGGTTCAGCGTTGAGGCAGAGAGC
TTGGAGGGGGCGTGGAGAACTCTGATCGAGAAAGTGCAAGAGGCCCGAGGGCATGCCCGACTCAGACATCTCTCCTTTAGTGGAATGAGT
GGGGCGAGACTCCTGGGCATCCACCATGATGCTGTCATCTTCCTGGCCGAGCAGCTCCCCGGAGCCCAGCGTTGCCAGCACTATAAGTTC
CGTTACCACCAGCAGGGAGAGGGCCAGGAGGAGCCGCCCCTGAATCCCCATGGGGCTGCTCGGGCAGAGGTCTATCTCCGCCCTGGGGTA
ACAGCGTGACCCTGGAGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGC
GAGGATGCCAGGCTGTGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGA

>43227_43227_4_KMT2B-CEACAM16_KMT2B_chr19_36228164_ENST00000420124_CEACAM16_chr19_45213768_ENST00000587331_length(amino acids)=2522AA_BP=20
MAAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQ
RGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARK
RGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKE
GPGPGPGTPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQK
LDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQ
EEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVI
KTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPA
PSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVS
PHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQ
QQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRD
RQDLATEDTSSASETESVPSRSRRGKVEAAGPGGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKF
GGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCV
KQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHR
VRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGR
GSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDY
ESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQPRWREALSGALQGGLRQVLQGLLSSKVVGPLLLCTQCGPDGK
QLHPGPCGLQAVSQRFEDGHYKSVHSFMEDMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNA
VLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHLEDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFE
ENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVNPDGFDVLRRVYVDF
EGINFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPAHLEAAEE
NQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGS
PSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDM
EVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDS
EAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLTASPADPT
RTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVR
PAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRLDEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRP
GEPAGEESPGPLQERSPLLPLPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAES
LEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRPGV

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Fusion Gene PPI Analysis for KMT2B-CEACAM16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2B-CEACAM16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2B-CEACAM16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource