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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2C-AUTS2 (FusionGDB2 ID:43235)

Fusion Gene Summary for KMT2C-AUTS2

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C-AUTS2
Fusion gene ID: 43235
HgeneTgene
Gene symbol

KMT2C

AUTS2

Gene ID

58508

26053

Gene namelysine methyltransferase 2Cactivator of transcription and developmental regulator AUTS2
SynonymsHALR|KLEFS2|MLL3FBRSL2|MRD26
Cytomap

7q36.1

7q11.22

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage leautism susceptibility gene 2 proteinAUTS2, activator of transcription and developmental regulatorautism susceptibility candidate 2autism-related protein 1
Modification date2020032020200313
UniProtAcc

Q8NEZ4

Q8WXX7

Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000403018, ENST00000489774, 
ENST00000342771, ENST00000406775, 
Fusion gene scores* DoF score26 X 23 X 12=717625 X 24 X 10=6000
# samples 3227
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/6000*10)=-4.47393118833241
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2C [Title/Abstract] AND AUTS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2C(152132711)-AUTS2(69900738), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722

TgeneAUTS2

GO:0045944

positive regulation of transcription by RNA polymerase II

25519132

TgeneAUTS2

GO:0051571

positive regulation of histone H3-K4 methylation

25519132

TgeneAUTS2

GO:2000620

positive regulation of histone H4-K16 acetylation

25519132


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AUTS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07C-01AKMT2Cchr7

152132711

-AUTS2chr7

69900738

+


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Fusion Gene ORF analysis for KMT2C-AUTS2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262189ENST00000403018KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
5CDS-intronENST00000262189ENST00000489774KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
5CDS-intronENST00000355193ENST00000403018KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
5CDS-intronENST00000355193ENST00000489774KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
In-frameENST00000262189ENST00000342771KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
In-frameENST00000262189ENST00000406775KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
In-frameENST00000355193ENST00000342771KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
In-frameENST00000355193ENST00000406775KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-3CDSENST00000485241ENST00000342771KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-3CDSENST00000485241ENST00000406775KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-3CDSENST00000485655ENST00000342771KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-3CDSENST00000485655ENST00000406775KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-intronENST00000485241ENST00000403018KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-intronENST00000485241ENST00000489774KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-intronENST00000485655ENST00000403018KMT2Cchr7

152132711

-AUTS2chr7

69900738

+
intron-intronENST00000485655ENST00000489774KMT2Cchr7

152132711

-AUTS2chr7

69900738

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262189KMT2Cchr7152132711-ENST00000406775AUTS2chr769900738+49353806893427912
ENST00000262189KMT2Cchr7152132711-ENST00000342771AUTS2chr769900738+55723806893499936
ENST00000355193KMT2Cchr7152132711-ENST00000406775AUTS2chr769900738+49353806893427912
ENST00000355193KMT2Cchr7152132711-ENST00000342771AUTS2chr769900738+55723806893499936

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000406775KMT2Cchr7152132711-AUTS2chr769900738+0.0087032510.99129677
ENST00000262189ENST00000342771KMT2Cchr7152132711-AUTS2chr769900738+0.0063198780.9936801
ENST00000355193ENST00000406775KMT2Cchr7152132711-AUTS2chr769900738+0.0087032510.99129677
ENST00000355193ENST00000342771KMT2Cchr7152132711-AUTS2chr769900738+0.0063198780.9936801

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Fusion Genomic Features for KMT2C-AUTS2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KMT2Cchr7152132710-AUTS2chr769900737+3.98E-070.99999964
KMT2Cchr7152132710-AUTS2chr769900737+3.98E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KMT2C-AUTS2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:152132711/chr7:69900738)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

AUTS2

Q8WXX7

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed:25519132). As a consequence, the complex mediates transcriptional activation (PubMed:25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). {ECO:0000250|UniProtKB:A0A087WPF7, ECO:0000269|PubMed:25519132}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-15934_46534912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-16034_46534969.0DNA bindingNote=A.T hook
TgeneAUTS2chr7:152132711chr7:69900738ENST000003427713191122_11812201260.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319288_4712201260.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319525_5482201260.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319545_6462201260.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000403018051122_11810267.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805288_4710267.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805525_5480267.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805545_6460267.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST000004067753181122_11812201236.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318288_4712201236.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318525_5482201236.0Compositional biasHis-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318545_6462201236.0Compositional biasPro-rich
TgeneAUTS2chr7:152132711chr7:69900738ENST00000342771319289_4722201260.0RegionImportant for regulation of lamellipodia formation
TgeneAUTS2chr7:152132711chr7:69900738ENST0000040301805289_4720267.0RegionImportant for regulation of lamellipodia formation
TgeneAUTS2chr7:152132711chr7:69900738ENST00000406775318289_4722201236.0RegionImportant for regulation of lamellipodia formation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591338_1366534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591754_1787534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593054_3081534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593173_3272534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593391_3433534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159644_672534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-15992_112534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601338_1366534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601754_1787534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603054_3081534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603173_3272534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603391_3433534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160644_672534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-16092_112534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591719_1796534912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591834_2281534912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1592412_2630534912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1592690_2786534912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593012_3509534912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1593277_3381534912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601719_1796534969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601834_2281534969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1602412_2630534969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1602690_2786534969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603012_3509534969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1603277_3381534969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159436_489534912.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594545_4605534912.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594606_4691534912.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594771_4887534912.0DomainSET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594895_4911534912.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160436_489534969.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604545_4605534969.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604606_4691534969.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604771_4887534969.0DomainSET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604895_4911534969.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594848_4849534912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604848_4849534969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591007_1057534912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1591084_1139534912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159227_262534912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159283_331534912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159341_391534912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159344_389534912.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159388_438534912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594399_4439534912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-1594460_4507534912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159464_520534912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000262189-159957_1010534912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601007_1057534969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1601084_1139534969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160227_262534969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160283_331534969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160341_391534969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160344_389534969.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160388_438534969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604399_4439534969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-1604460_4507534969.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160464_520534969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:69900738ENST00000355193-160957_1010534969.0Zinc fingerPHD-type 5


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Fusion Gene Sequence for KMT2C-AUTS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43235_43235_1_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000262189_AUTS2_chr7_69900738_ENST00000342771_length(transcript)=5572nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAATGTGACAGTGACAGTGACCAGGAAGAGAAGGCATCAGATGCCAGCTCTGAAAAACTCTTCAACACTGTTA
TTGTAAACAAAGATCCGGAGTTAGGTGTTGGCACGCTACCAGAACATGACAGCCAGGATGCAGGGCCGATTGTCCCCAAGATATCGGGTC
TAGAGAGAAGCCAGGAGAAGAGCCAGGACTGTTGCAAAGAGCCAATCTTTGAGCCTGTGGTGCTTAAAGACCCCTGCCCTCAGGTCGCAC
AGCCAATACCCCAGCCGCAGACGGAGCCCCAACTCCGAGCTCCTTCTCCGGACCCTGACTTGGTGCAGCGCACAGAGGCCCCACCTCAAC
CCCCACCTCTGAGTACACAGCCACCACAGGGCCCTCCTGAGGCCCAGCTCCAGCCTGCCCCGCAGCCTCAGGTGCAGAGGCCACCCAGGC
CACAGTCCCCCACCCAGCTGCTCCATCAGAACCTCCCACCTGTGCAGGCCCACCCCTCTGCTCAGAGCCTCTCCCAGCCATTGTCAGCCT
ACAACAGCAGTAGCTTAAGCCTCAACAGTTTAAGCAGCAGCAGAAGCAGCACTCCAGCGAAGACTCAGCCCGCCCCACCTCACATCTCCC
ACCACCCCTCTGCCTCCCCGTTCCCCCTCTCCCTGCCCAACCACAGCCCCCTGCACAGCTTCACACCCACCCTCCAGCCCCCCGCACACT
CACATCACCCCAATATGTTTGCCCCTCCCACTGCTCTGCCTCCTCCACCACCACTGACATCAGGAAGTCTGCAGGTGGCCGGACACCCGG
CCGGGAGCACTTACTCAGAGCAAGACATCTTGCGACAGGAACTGAACACTCGTTTTTTGGCCTCTCAGAGTGCTGACCGCGGGGCTTCCC
TGGGCCCTCCGCCCTACCTGCGGACCGAGTTCCATCAGCACCAGCACCAGCACCAGCACACCCACCAGCACACGCACCAGCACACCTTCA
CGCCGTTCCCCCACGCCATCCCACCCACCGCCATCATGCCGACGCCAGCACCTCCCATGTTTGACAAATACCCTACAAAAGTTGACCCAT
TCTACCGGCACAGTCTCTTCCATTCCTATCCTCCTGCAGTGTCGGGCATCCCCCCTATGATCCCACCCACTGGCCCTTTTGGTTCACTAC
AAGGAGCATTTCAGCCGAAGACATCCAACCCTATCGATGTCGCTGCTCGGCCTGGGACAGTCCCACACACTTTACTCCAAAAGGACCCGA
GGTTGACAGATCCTTTCAGACCTATGTTAAGGAAACCAGGGAAGTGGTGTGCTATGCATGTTCACATCGCCTGGCAGATTTACCACCACC
AACAGAAAGTCAAGAAACAGATGCAGTCAGACCCACATAAGCTGGACTTTGGACTGAAACCTGAGTTCCTGAGCCGCCCTCCAGGCCCCA
GTCTTTTTGGAGCCATCCACCACCCCCATGACCTGGCACGGCCTTCAACTTTGTTCTCTGCCGCTGGTGCTGCACACCCAACTGGGACCC
CTTTTGGGCCACCTCCTCATCACAGCAACTTCCTCAACCCTGCTGCCCACCTAGAGCCTTTTAATCGGCCGTCTACATTCACAGGCCTAG
CAGCAGTTGGTGGCAATGCCTTCGGGGGACTTGGAAATCCTTCCGTTACACCCAACTCAATGTTCGGCCACAAGGATGGCCCCAGTGTGC
AGAACTTTAGCAACCCTCACGAACCCTGGAACCGGCTGCACCGAACGCCTCCGTCGTTCCCGACCCCTCCGCCCTGGCTGAAGCCAGGGG
AGCTGGAGCGCAGCGCGTCCGCTGCAGCTCATGACAGAGATAGAGATGTAGATAAACGAGACTCATCTGTTAGTAAAGATGACAAAGAAA
GGGAAAGCGTCGAGAAGAGACACTCCAGCCACCCTTCACCAGCACCTGTCCTCCCGGTGAATGCCCTGGGACATACCCGCAGCTCCACTG
AACAGATCCGGGCTCATCTGAACACTGAGGCTCGGGAGAAGGACAAACCCAAAGAGAGGGAGAGAGACCACTCGGAATCCCGCAAGGACC
TGGCCGCCGACGAGCACAAGGCGAAAGAGGGCCACCTGCCCGAGAAGGACGGGCACGGCCACGAGGGGCGCGCCGCGGGCGAAGAGGCCA
AGCAGCTGGCCCGGGTGCCGTCTCCCTACGTGCGGACCCCGGTGGTGGAGAGTGCCAGGCCCAACAGCACCTCGAGCCGGGAGGCCGAGC
CGCGCAAGGGTGAGCCGGCCTACGAGAACCCCAAGAAGAGCTCCGAGGTCAAGGTGAAGGAGGAGCGGAAGGAAGACCATGACCTGCCTC
CAGAGGCCCCGCAGACCCACCGGGCCTCGGAGCCGCCGCCTCCCAACTCCTCGTCCAGCGTGCACCCGGGGCCCCTGGCCTCGATGCCCA
TGACGGTGGGGGTGACGGGCATTCACCCCATGAACAGCATCAGCAGCCTGGACAGGACTCGCATGATGACCCCCTTCATGGGCATCAGCC
CCCTCCCGGGCGGAGAGCGCTTCCCGTACCCTTCTTTCCACTGGGACCCCATCCGGGACCCCTTGAGGGATCCTTACCGAGAACTTGACA
TTCACCGGAGAGACCCGCTGGGCAGGGACTTCCTGCTAAGGAACGACCCGCTCCACCGGCTCTCGACTCCCCGGCTGTACGAAGCCGACC
GCTCCTTCAGGGACCGGGAGCCTCACGACTACAGCCACCACCACCACCACCACCACCACCCGCTGTCTGTGGACCCTCGGCGGGAGCACG
AGCGGGGAGGCCACCTGGACGAGCGGGAGCGCTTGCACATGCTCAGAGAAGACTACGAGCACACGCGGCTCCACTCCGTGCACCCCGCCT
CCCTCGACGGACACCTCCCCCACCCCAGCCTCATCACCCCGGGACTCCCCAGCATGCACTATCCCCGCATCAGCCCCACCGCGGGCAACC
AGAACGGACTCCTCAACAAGACCCCTCCGACAGCAGCGCTGAGCGCACCTCCCCCGCTCATCTCCACGCTGGGGGGCCGCCCGGTCTCTC
CCAGAAGGACGACTCCTCTGTCCGCAGAGATAAGGGAGAGGCCCCCTTCCCACACGCTGAAGGATATCGAGGCCCGATAAGCCGAGAACA
GGAGCAAGAACGAGGAAGAAGAAACCCTAGGCAGACACCAGGCCAGGCTTGAGAGACAGAACTCCTGCATGGCTCACACAGACTGGGGGG
GAAAGCCCCACCCCTTCCCCTTGTAAAAAATGTATAGACTCAGTGCACATTTTGAAATGTTTTGTATATTATATGTTGAGATTTTTCAGA
TCTTTTAGCCCAGTCATATGTTCTCACGTCTCCTACTTTTTGTTTCTCGTATAAAACTTTTTGATTTGAACCAAAACAGTGAAGATGACA
ACACACACCAATTGGATGATAATTGTAGCGGGGGCGGTGGGGGGGAGAAGTCCACGCCATCCATCATGCAAAATTCTTTCAGATGAGGTG
GGAAGGCCGTGTACATAGTTATGTAAAAAGAGATTGCTTCATGAGCTAATGGTTCATATATGCAAAAGGGTAAGATGAAAGCTTTACTTT
GTACAAATGTAAATAGATAAAGTAACATAATACATTAATACTTCTTAAAATGTGCTATTTGCAAACTTACTTAATATCAGTGAACACAGT
CGGCTAAAGCTGTGTTCCCATATATTGTTATAGACAGCTAAACCCTTCAACTATGCAATGAATGTTCGGGCTTTTCACAAAAGCCCGCCT
AACTCAAAGGAGCCTTTTCAAATCCATTTACAGCATACTTAAGGTCATATTTTCCCTGAACAAGCGCTTACGTGATATGACTCTGTTTTC
CTTGCTTGTTTTTTTTCAAACGGAGAAACATCCTGTTTTGCAAATTGGACCCCAGGCTGGAACTTAGCATCTGAAGTTGCCGCTTGTGGG
CTCTGGGGGAAAGTGTAGCCCCGGAGAGGTAACTGAGGACATGAGCAACCAGTGCCAGGGAGGGTGGGATTTGCCAGATGCCAAAATCAG
GGGACGGGTGGTGGTGTCTGTCAGACACACACAGGTCGCCAGTGACTTCACACACACCTCATGTGAGAACCATGCCTTTTTTAGTGTGTC
CTATTTCATACCTGTACACACTTCCTCGTTTTGTAATGAGATTTACTTACACCCAAACAGATCCTGAAAGAAAGCTTCAAGTTTTCTCAG
ATGATGGATATGTTTTCACTGTATTCAATAACTGACGGATGTAAGGTGCACGTTTCCTGATGTGACGCACTGTATTCCAGCTGGTGATCA
AGTCTGGGAACAGCCGTAACAGGTCAACCTTGTGGAGCCATCGCGAGTTAGAGGGTGAAAGATGGCAGAAAAAAAAGTCTTGTGTGTGAG
TGTGTTTTTTGAGTTTGCATCAATCTTAATGTCTCTTCATAATACTTTTATAATACATTAAGCCTCTTGTCTACATATTTGGAGAGAATA
TGACTTTACTAGCAGAGAAATACAATATATCTTGTCTACTGGACTGTAAAATATATGTATGAAATAAAATTAGTTCCATTTGGTCTTCTA
GTATATTAAAGTGCTATCTGACGTTGTTATCCTGTTTTTGCAAAAAAAAAAAAAAAAAAAAGTTAACTACAGACCATTGTTTCTAATAAG
CAGAGAGATCTATTTTAGTAGTAAACTGAAGGTTTAGTTGTGAGCTTCAGATTTTGTGAACTCCAGATGTTGTGCGGTGTTTTTTTTTTT
TTTTAAGACAACAACTAAAAAAAATGCAAGGAATATGTACACTGGAACTGTAGTGGTAGCTTTCAGTATTGTAAAGAGATTGTTCTATAC
GGACCTTTTTGCTGTTTATCCTGTATGTAATAAAGTCCTTTCTAGATCCTATGTGAAAAGAAAAGTGAAGCAACTGAATCTTCAGCATGT
TCTCATCGGCGGAGCCTTCTTGTGTAATGTAAACTGTGCCATGTTATTAAAAAATGTGAACTAAGCTTCCAGCTGCTTGTTTGTGTGAGG
TGACCATCATTACCTTAGGGAAGAAGCCATACCTGTACAAGACCGGGCTCTTGAAAAGAAACACCTCGAACCCAGCCCGTGTAAGAACAG

>43235_43235_1_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000262189_AUTS2_chr7_69900738_ENST00000342771_length(amino acids)=936AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLK
PEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNS
MFGHKDGPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPV
NALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESAR
PNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRT
RMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHH
PLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPL

--------------------------------------------------------------
>43235_43235_2_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000262189_AUTS2_chr7_69900738_ENST00000406775_length(transcript)=4935nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAATGTGACAGTGACAGTGACCAGGAAGAGAAGGCATCAGATGCCAGCTCTGAAAAACTCTTCAACACTGTTA
TTGTAAACAAAGATCCGGAGTTAGGTGTTGGCACGCTACCAGAACATGACAGCCAGGATGCAGGGCCGATTGTCCCCAAGATATCGGGTC
TAGAGAGAAGCCAGGAGAAGAGCCAGGACTGTTGCAAAGAGCCAATCTTTGAGCCTGTGGTGCTTAAAGACCCCTGCCCTCAGGTCGCAC
AGCCAATACCCCAGCCGCAGACGGAGCCCCAACTCCGAGCTCCTTCTCCGGACCCTGACTTGGTGCAGCGCACAGAGGCCCCACCTCAAC
CCCCACCTCTGAGTACACAGCCACCACAGGGCCCTCCTGAGGCCCAGCTCCAGCCTGCCCCGCAGCCTCAGGTGCAGAGGCCACCCAGGC
CACAGTCCCCCACCCAGCTGCTCCATCAGAACCTCCCACCTGTGCAGGCCCACCCCTCTGCTCAGAGCCTCTCCCAGCCATTGTCAGCCT
ACAACAGCAGTAGCTTAAGCCTCAACAGTTTAAGCAGCAGCAGAAGCAGCACTCCAGCGAAGACTCAGCCCGCCCCACCTCACATCTCCC
ACCACCCCTCTGCCTCCCCGTTCCCCCTCTCCCTGCCCAACCACAGCCCCCTGCACAGCTTCACACCCACCCTCCAGCCCCCCGCACACT
CACATCACCCCAATATGTTTGCCCCTCCCACTGCTCTGCCTCCTCCACCACCACTGACATCAGGAAGTCTGCAGGTGGCCGGACACCCGG
CCGGGAGCACTTACTCAGAGCAAGACATCTTGCGACAGGAACTGAACACTCGTTTTTTGGCCTCTCAGAGTGCTGACCGCGGGGCTTCCC
TGGGCCCTCCGCCCTACCTGCGGACCGAGTTCCATCAGCACCAGCACCAGCACCAGCACACCCACCAGCACACGCACCAGCACACCTTCA
CGCCGTTCCCCCACGCCATCCCACCCACCGCCATCATGCCGACGCCAGCACCTCCCATGTTTGACAAATACCCTACAAAAGTTGACCCAT
TCTACCGGCACAGTCTCTTCCATTCCTATCCTCCTGCAGTGTCGGGCATCCCCCCTATGATCCCACCCACTGGCCCTTTTGGTTCACTAC
AAGGAGCATTTCAGCCGAAGTTGACAGATCCTTTCAGACCTATGTTAAGGAAACCAGGGAAGTGGTGTGCTATGCATGTTCACATCGCCT
GGCAGATTTACCACCACCAACAGAAAGTCAAGAAACAGATGCAGTCAGACCCACATAAGCTGGACTTTGGACTGAAACCTGAGTTCCTGA
GCCGCCCTCCAGGCCCCAGTCTTTTTGGAGCCATCCACCACCCCCATGACCTGGCACGGCCTTCAACTTTGTTCTCTGCCGCTGGTGCTG
CACACCCAACTGGGACCCCTTTTGGGCCACCTCCTCATCACAGCAACTTCCTCAACCCTGCTGCCCACCTAGAGCCTTTTAATCGGCCGT
CTACATTCACAGGCCTAGCAGCAGTTGGTGGCAATGCCTTCGGGGGACTTGGAAATCCTTCCGTTACACCCAACTCAATGTTCGGCCACA
AGGATGGCCCCAGTGTGCAGAACTTTAGCAACCCTCACGAACCCTGGAACCGGCTGCACCGAACGCCTCCGTCGTTCCCGACCCCTCCGC
CCTGGCTGAAGCCAGGGGAGCTGGAGCGCAGCGCGTCCGCTGCAGCTCATGACAGAGATAGAGATGTAGATAAACGAGACTCATCTGTTA
GTAAAGATGACAAAGAAAGGGAAAGCGTCGAGAAGAGACACTCCAGCCACCCTTCACCAGCACCTGTCCTCCCGGTGAATGCCCTGGGAC
ATACCCGCAGCTCCACTGAACAGATCCGGGCTCATCTGAACACTGAGGCTCGGGAGAAGGACAAACCCAAAGAGAGGGAGAGAGACCACT
CGGAATCCCGCAAGGACCTGGCCGCCGACGAGCACAAGGCGAAAGAGGGCCACCTGCCCGAGAAGGACGGGCACGGCCACGAGGGGCGCG
CCGCGGGCGAAGAGGCCAAGCAGCTGGCCCGGGTGCCGTCTCCCTACGTGCGGACCCCGGTGGTGGAGAGTGCCAGGCCCAACAGCACCT
CGAGCCGGGAGGCCGAGCCGCGCAAGGGTGAGCCGGCCTACGAGAACCCCAAGAAGAGCTCCGAGGTCAAGGTGAAGGAGGAGCGGAAGG
AAGACCATGACCTGCCTCCAGAGGCCCCGCAGACCCACCGGGCCTCGGAGCCGCCGCCTCCCAACTCCTCGTCCAGCGTGCACCCGGGGC
CCCTGGCCTCGATGCCCATGACGGTGGGGGTGACGGGCATTCACCCCATGAACAGCATCAGCAGCCTGGACAGGACTCGCATGATGACCC
CCTTCATGGGCATCAGCCCCCTCCCGGGCGGAGAGCGCTTCCCGTACCCTTCTTTCCACTGGGACCCCATCCGGGACCCCTTGAGGGATC
CTTACCGAGAACTTGACATTCACCGGAGAGACCCGCTGGGCAGGGACTTCCTGCTAAGGAACGACCCGCTCCACCGGCTCTCGACTCCCC
GGCTGTACGAAGCCGACCGCTCCTTCAGGGACCGGGAGCCTCACGACTACAGCCACCACCACCACCACCACCACCACCCGCTGTCTGTGG
ACCCTCGGCGGGAGCACGAGCGGGGAGGCCACCTGGACGAGCGGGAGCGCTTGCACATGCTCAGAGAAGACTACGAGCACACGCGGCTCC
ACTCCGTGCACCCCGCCTCCCTCGACGGACACCTCCCCCACCCCAGCCTCATCACCCCGGGACTCCCCAGCATGCACTATCCCCGCATCA
GCCCCACCGCGGGCAACCAGAACGGACTCCTCAACAAGACCCCTCCGACAGCAGCGCTGAGCGCACCTCCCCCGCTCATCTCCACGCTGG
GGGGCCGCCCGGTCTCTCCCAGAAGGACGACTCCTCTGTCCGCAGAGATAAGGGAGAGGCCCCCTTCCCACACGCTGAAGGATATCGAGG
CCCGATAAGCCGAGAACAGGAGCAAGAACGAGGAAGAAGAAACCCTAGGCAGACACCAGGCCAGGCTTGAGAGACAGAACTCCTGCATGG
CTCACACAGACTGGGGGGGAAAGCCCCACCCCTTCCCCTTGTAAAAAATGTATAGACTCAGTGCACATTTTGAAATGTTTTGTATATTAT
ATGTTGAGATTTTTCAGATCTTTTAGCCCAGTCATATGTTCTCACGTCTCCTACTTTTTGTTTCTCGTATAAAACTTTTTGATTTGAACC
AAAACAGTGAAGATGACAACACACACCAATTGGATGATAATTGTAGCGGGGGCGGTGGGGGGGAGAAGTCCACGCCATCCATCATGCAAA
ATTCTTTCAGATGAGGTGGGAAGGCCGTGTACATAGTTATGTAAAAAGAGATTGCTTCATGAGCTAATGGTTCATATATGCAAAAGGGTA
AGATGAAAGCTTTACTTTGTACAAATGTAAATAGATAAAGTAACATAATACATTAATACTTCTTAAAATGTGCTATTTGCAAACTTACTT
AATATCAGTGAACACAGTCGGCTAAAGCTGTGTTCCCATATATTGTTATAGACAGCTAAACCCTTCAACTATGCAATGAATGTTCGGGCT
TTTCACAAAAGCCCGCCTAACTCAAAGGAGCCTTTTCAAATCCATTTACAGCATACTTAAGGTCATATTTTCCCTGAACAAGCGCTTACG
TGATATGACTCTGTTTTCCTTGCTTGTTTTTTTTCAAACGGAGAAACATCCTGTTTTGCAAATTGGACCCCAGGCTGGAACTTAGCATCT
GAAGTTGCCGCTTGTGGGCTCTGGGGGAAAGTGTAGCCCCGGAGAGGTAACTGAGGACATGAGCAACCAGTGCCAGGGAGGGTGGGATTT
GCCAGATGCCAAAATCAGGGGACGGGTGGTGGTGTCTGTCAGACACACACAGGTCGCCAGTGACTTCACACACACCTCATGTGAGAACCA
TGCCTTTTTTAGTGTGTCCTATTTCATACCTGTACACACTTCCTCGTTTTGTAATGAGATTTACTTACACCCAAACAGATCCTGAAAGAA
AGCTTCAAGTTTTCTCAGATGATGGATATGTTTTCACTGTATTCAATAACTGACGGATGTAAGGTGCACGTTTCCTGATGTGACGCACTG
TATTCCAGCTGGTGATCAAGTCTGGGAACAGCCGTAACAGGTCAACCTTGTGGAGCCATCGCGAGTTAGAGGGTGAAAGATGGCAGAAAA
AAAAGTCTTGTGTGTGAGTGTGTTTTTTGAGTTTGCATCAATCTTAATGTCTCTTCATAATACTTTTATAATACATTAAGCCTCTTGTCT
ACATATTTGGAGAGAATATGACTTTACTAGCAGAGAAATACAATATATCTTGTCTACTGGACTGTAAAATATATGTATGAAATAAAATTA

>43235_43235_2_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000262189_AUTS2_chr7_69900738_ENST00000406775_length(amino acids)=912AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLAR
PSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLH
RTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREK
DKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKS
SEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFH
WDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHM
LREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRER

--------------------------------------------------------------
>43235_43235_3_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000355193_AUTS2_chr7_69900738_ENST00000342771_length(transcript)=5572nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAATGTGACAGTGACAGTGACCAGGAAGAGAAGGCATCAGATGCCAGCTCTGAAAAACTCTTCAACACTGTTA
TTGTAAACAAAGATCCGGAGTTAGGTGTTGGCACGCTACCAGAACATGACAGCCAGGATGCAGGGCCGATTGTCCCCAAGATATCGGGTC
TAGAGAGAAGCCAGGAGAAGAGCCAGGACTGTTGCAAAGAGCCAATCTTTGAGCCTGTGGTGCTTAAAGACCCCTGCCCTCAGGTCGCAC
AGCCAATACCCCAGCCGCAGACGGAGCCCCAACTCCGAGCTCCTTCTCCGGACCCTGACTTGGTGCAGCGCACAGAGGCCCCACCTCAAC
CCCCACCTCTGAGTACACAGCCACCACAGGGCCCTCCTGAGGCCCAGCTCCAGCCTGCCCCGCAGCCTCAGGTGCAGAGGCCACCCAGGC
CACAGTCCCCCACCCAGCTGCTCCATCAGAACCTCCCACCTGTGCAGGCCCACCCCTCTGCTCAGAGCCTCTCCCAGCCATTGTCAGCCT
ACAACAGCAGTAGCTTAAGCCTCAACAGTTTAAGCAGCAGCAGAAGCAGCACTCCAGCGAAGACTCAGCCCGCCCCACCTCACATCTCCC
ACCACCCCTCTGCCTCCCCGTTCCCCCTCTCCCTGCCCAACCACAGCCCCCTGCACAGCTTCACACCCACCCTCCAGCCCCCCGCACACT
CACATCACCCCAATATGTTTGCCCCTCCCACTGCTCTGCCTCCTCCACCACCACTGACATCAGGAAGTCTGCAGGTGGCCGGACACCCGG
CCGGGAGCACTTACTCAGAGCAAGACATCTTGCGACAGGAACTGAACACTCGTTTTTTGGCCTCTCAGAGTGCTGACCGCGGGGCTTCCC
TGGGCCCTCCGCCCTACCTGCGGACCGAGTTCCATCAGCACCAGCACCAGCACCAGCACACCCACCAGCACACGCACCAGCACACCTTCA
CGCCGTTCCCCCACGCCATCCCACCCACCGCCATCATGCCGACGCCAGCACCTCCCATGTTTGACAAATACCCTACAAAAGTTGACCCAT
TCTACCGGCACAGTCTCTTCCATTCCTATCCTCCTGCAGTGTCGGGCATCCCCCCTATGATCCCACCCACTGGCCCTTTTGGTTCACTAC
AAGGAGCATTTCAGCCGAAGACATCCAACCCTATCGATGTCGCTGCTCGGCCTGGGACAGTCCCACACACTTTACTCCAAAAGGACCCGA
GGTTGACAGATCCTTTCAGACCTATGTTAAGGAAACCAGGGAAGTGGTGTGCTATGCATGTTCACATCGCCTGGCAGATTTACCACCACC
AACAGAAAGTCAAGAAACAGATGCAGTCAGACCCACATAAGCTGGACTTTGGACTGAAACCTGAGTTCCTGAGCCGCCCTCCAGGCCCCA
GTCTTTTTGGAGCCATCCACCACCCCCATGACCTGGCACGGCCTTCAACTTTGTTCTCTGCCGCTGGTGCTGCACACCCAACTGGGACCC
CTTTTGGGCCACCTCCTCATCACAGCAACTTCCTCAACCCTGCTGCCCACCTAGAGCCTTTTAATCGGCCGTCTACATTCACAGGCCTAG
CAGCAGTTGGTGGCAATGCCTTCGGGGGACTTGGAAATCCTTCCGTTACACCCAACTCAATGTTCGGCCACAAGGATGGCCCCAGTGTGC
AGAACTTTAGCAACCCTCACGAACCCTGGAACCGGCTGCACCGAACGCCTCCGTCGTTCCCGACCCCTCCGCCCTGGCTGAAGCCAGGGG
AGCTGGAGCGCAGCGCGTCCGCTGCAGCTCATGACAGAGATAGAGATGTAGATAAACGAGACTCATCTGTTAGTAAAGATGACAAAGAAA
GGGAAAGCGTCGAGAAGAGACACTCCAGCCACCCTTCACCAGCACCTGTCCTCCCGGTGAATGCCCTGGGACATACCCGCAGCTCCACTG
AACAGATCCGGGCTCATCTGAACACTGAGGCTCGGGAGAAGGACAAACCCAAAGAGAGGGAGAGAGACCACTCGGAATCCCGCAAGGACC
TGGCCGCCGACGAGCACAAGGCGAAAGAGGGCCACCTGCCCGAGAAGGACGGGCACGGCCACGAGGGGCGCGCCGCGGGCGAAGAGGCCA
AGCAGCTGGCCCGGGTGCCGTCTCCCTACGTGCGGACCCCGGTGGTGGAGAGTGCCAGGCCCAACAGCACCTCGAGCCGGGAGGCCGAGC
CGCGCAAGGGTGAGCCGGCCTACGAGAACCCCAAGAAGAGCTCCGAGGTCAAGGTGAAGGAGGAGCGGAAGGAAGACCATGACCTGCCTC
CAGAGGCCCCGCAGACCCACCGGGCCTCGGAGCCGCCGCCTCCCAACTCCTCGTCCAGCGTGCACCCGGGGCCCCTGGCCTCGATGCCCA
TGACGGTGGGGGTGACGGGCATTCACCCCATGAACAGCATCAGCAGCCTGGACAGGACTCGCATGATGACCCCCTTCATGGGCATCAGCC
CCCTCCCGGGCGGAGAGCGCTTCCCGTACCCTTCTTTCCACTGGGACCCCATCCGGGACCCCTTGAGGGATCCTTACCGAGAACTTGACA
TTCACCGGAGAGACCCGCTGGGCAGGGACTTCCTGCTAAGGAACGACCCGCTCCACCGGCTCTCGACTCCCCGGCTGTACGAAGCCGACC
GCTCCTTCAGGGACCGGGAGCCTCACGACTACAGCCACCACCACCACCACCACCACCACCCGCTGTCTGTGGACCCTCGGCGGGAGCACG
AGCGGGGAGGCCACCTGGACGAGCGGGAGCGCTTGCACATGCTCAGAGAAGACTACGAGCACACGCGGCTCCACTCCGTGCACCCCGCCT
CCCTCGACGGACACCTCCCCCACCCCAGCCTCATCACCCCGGGACTCCCCAGCATGCACTATCCCCGCATCAGCCCCACCGCGGGCAACC
AGAACGGACTCCTCAACAAGACCCCTCCGACAGCAGCGCTGAGCGCACCTCCCCCGCTCATCTCCACGCTGGGGGGCCGCCCGGTCTCTC
CCAGAAGGACGACTCCTCTGTCCGCAGAGATAAGGGAGAGGCCCCCTTCCCACACGCTGAAGGATATCGAGGCCCGATAAGCCGAGAACA
GGAGCAAGAACGAGGAAGAAGAAACCCTAGGCAGACACCAGGCCAGGCTTGAGAGACAGAACTCCTGCATGGCTCACACAGACTGGGGGG
GAAAGCCCCACCCCTTCCCCTTGTAAAAAATGTATAGACTCAGTGCACATTTTGAAATGTTTTGTATATTATATGTTGAGATTTTTCAGA
TCTTTTAGCCCAGTCATATGTTCTCACGTCTCCTACTTTTTGTTTCTCGTATAAAACTTTTTGATTTGAACCAAAACAGTGAAGATGACA
ACACACACCAATTGGATGATAATTGTAGCGGGGGCGGTGGGGGGGAGAAGTCCACGCCATCCATCATGCAAAATTCTTTCAGATGAGGTG
GGAAGGCCGTGTACATAGTTATGTAAAAAGAGATTGCTTCATGAGCTAATGGTTCATATATGCAAAAGGGTAAGATGAAAGCTTTACTTT
GTACAAATGTAAATAGATAAAGTAACATAATACATTAATACTTCTTAAAATGTGCTATTTGCAAACTTACTTAATATCAGTGAACACAGT
CGGCTAAAGCTGTGTTCCCATATATTGTTATAGACAGCTAAACCCTTCAACTATGCAATGAATGTTCGGGCTTTTCACAAAAGCCCGCCT
AACTCAAAGGAGCCTTTTCAAATCCATTTACAGCATACTTAAGGTCATATTTTCCCTGAACAAGCGCTTACGTGATATGACTCTGTTTTC
CTTGCTTGTTTTTTTTCAAACGGAGAAACATCCTGTTTTGCAAATTGGACCCCAGGCTGGAACTTAGCATCTGAAGTTGCCGCTTGTGGG
CTCTGGGGGAAAGTGTAGCCCCGGAGAGGTAACTGAGGACATGAGCAACCAGTGCCAGGGAGGGTGGGATTTGCCAGATGCCAAAATCAG
GGGACGGGTGGTGGTGTCTGTCAGACACACACAGGTCGCCAGTGACTTCACACACACCTCATGTGAGAACCATGCCTTTTTTAGTGTGTC
CTATTTCATACCTGTACACACTTCCTCGTTTTGTAATGAGATTTACTTACACCCAAACAGATCCTGAAAGAAAGCTTCAAGTTTTCTCAG
ATGATGGATATGTTTTCACTGTATTCAATAACTGACGGATGTAAGGTGCACGTTTCCTGATGTGACGCACTGTATTCCAGCTGGTGATCA
AGTCTGGGAACAGCCGTAACAGGTCAACCTTGTGGAGCCATCGCGAGTTAGAGGGTGAAAGATGGCAGAAAAAAAAGTCTTGTGTGTGAG
TGTGTTTTTTGAGTTTGCATCAATCTTAATGTCTCTTCATAATACTTTTATAATACATTAAGCCTCTTGTCTACATATTTGGAGAGAATA
TGACTTTACTAGCAGAGAAATACAATATATCTTGTCTACTGGACTGTAAAATATATGTATGAAATAAAATTAGTTCCATTTGGTCTTCTA
GTATATTAAAGTGCTATCTGACGTTGTTATCCTGTTTTTGCAAAAAAAAAAAAAAAAAAAAGTTAACTACAGACCATTGTTTCTAATAAG
CAGAGAGATCTATTTTAGTAGTAAACTGAAGGTTTAGTTGTGAGCTTCAGATTTTGTGAACTCCAGATGTTGTGCGGTGTTTTTTTTTTT
TTTTAAGACAACAACTAAAAAAAATGCAAGGAATATGTACACTGGAACTGTAGTGGTAGCTTTCAGTATTGTAAAGAGATTGTTCTATAC
GGACCTTTTTGCTGTTTATCCTGTATGTAATAAAGTCCTTTCTAGATCCTATGTGAAAAGAAAAGTGAAGCAACTGAATCTTCAGCATGT
TCTCATCGGCGGAGCCTTCTTGTGTAATGTAAACTGTGCCATGTTATTAAAAAATGTGAACTAAGCTTCCAGCTGCTTGTTTGTGTGAGG
TGACCATCATTACCTTAGGGAAGAAGCCATACCTGTACAAGACCGGGCTCTTGAAAAGAAACACCTCGAACCCAGCCCGTGTAAGAACAG

>43235_43235_3_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000355193_AUTS2_chr7_69900738_ENST00000342771_length(amino acids)=936AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLK
PEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNS
MFGHKDGPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPV
NALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESAR
PNSTSSREAEPRKGEPAYENPKKSSEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRT
RMMTPFMGISPLPGGERFPYPSFHWDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHH
PLSVDPRREHERGGHLDERERLHMLREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPL

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>43235_43235_4_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000355193_AUTS2_chr7_69900738_ENST00000406775_length(transcript)=4935nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAATGTGACAGTGACAGTGACCAGGAAGAGAAGGCATCAGATGCCAGCTCTGAAAAACTCTTCAACACTGTTA
TTGTAAACAAAGATCCGGAGTTAGGTGTTGGCACGCTACCAGAACATGACAGCCAGGATGCAGGGCCGATTGTCCCCAAGATATCGGGTC
TAGAGAGAAGCCAGGAGAAGAGCCAGGACTGTTGCAAAGAGCCAATCTTTGAGCCTGTGGTGCTTAAAGACCCCTGCCCTCAGGTCGCAC
AGCCAATACCCCAGCCGCAGACGGAGCCCCAACTCCGAGCTCCTTCTCCGGACCCTGACTTGGTGCAGCGCACAGAGGCCCCACCTCAAC
CCCCACCTCTGAGTACACAGCCACCACAGGGCCCTCCTGAGGCCCAGCTCCAGCCTGCCCCGCAGCCTCAGGTGCAGAGGCCACCCAGGC
CACAGTCCCCCACCCAGCTGCTCCATCAGAACCTCCCACCTGTGCAGGCCCACCCCTCTGCTCAGAGCCTCTCCCAGCCATTGTCAGCCT
ACAACAGCAGTAGCTTAAGCCTCAACAGTTTAAGCAGCAGCAGAAGCAGCACTCCAGCGAAGACTCAGCCCGCCCCACCTCACATCTCCC
ACCACCCCTCTGCCTCCCCGTTCCCCCTCTCCCTGCCCAACCACAGCCCCCTGCACAGCTTCACACCCACCCTCCAGCCCCCCGCACACT
CACATCACCCCAATATGTTTGCCCCTCCCACTGCTCTGCCTCCTCCACCACCACTGACATCAGGAAGTCTGCAGGTGGCCGGACACCCGG
CCGGGAGCACTTACTCAGAGCAAGACATCTTGCGACAGGAACTGAACACTCGTTTTTTGGCCTCTCAGAGTGCTGACCGCGGGGCTTCCC
TGGGCCCTCCGCCCTACCTGCGGACCGAGTTCCATCAGCACCAGCACCAGCACCAGCACACCCACCAGCACACGCACCAGCACACCTTCA
CGCCGTTCCCCCACGCCATCCCACCCACCGCCATCATGCCGACGCCAGCACCTCCCATGTTTGACAAATACCCTACAAAAGTTGACCCAT
TCTACCGGCACAGTCTCTTCCATTCCTATCCTCCTGCAGTGTCGGGCATCCCCCCTATGATCCCACCCACTGGCCCTTTTGGTTCACTAC
AAGGAGCATTTCAGCCGAAGTTGACAGATCCTTTCAGACCTATGTTAAGGAAACCAGGGAAGTGGTGTGCTATGCATGTTCACATCGCCT
GGCAGATTTACCACCACCAACAGAAAGTCAAGAAACAGATGCAGTCAGACCCACATAAGCTGGACTTTGGACTGAAACCTGAGTTCCTGA
GCCGCCCTCCAGGCCCCAGTCTTTTTGGAGCCATCCACCACCCCCATGACCTGGCACGGCCTTCAACTTTGTTCTCTGCCGCTGGTGCTG
CACACCCAACTGGGACCCCTTTTGGGCCACCTCCTCATCACAGCAACTTCCTCAACCCTGCTGCCCACCTAGAGCCTTTTAATCGGCCGT
CTACATTCACAGGCCTAGCAGCAGTTGGTGGCAATGCCTTCGGGGGACTTGGAAATCCTTCCGTTACACCCAACTCAATGTTCGGCCACA
AGGATGGCCCCAGTGTGCAGAACTTTAGCAACCCTCACGAACCCTGGAACCGGCTGCACCGAACGCCTCCGTCGTTCCCGACCCCTCCGC
CCTGGCTGAAGCCAGGGGAGCTGGAGCGCAGCGCGTCCGCTGCAGCTCATGACAGAGATAGAGATGTAGATAAACGAGACTCATCTGTTA
GTAAAGATGACAAAGAAAGGGAAAGCGTCGAGAAGAGACACTCCAGCCACCCTTCACCAGCACCTGTCCTCCCGGTGAATGCCCTGGGAC
ATACCCGCAGCTCCACTGAACAGATCCGGGCTCATCTGAACACTGAGGCTCGGGAGAAGGACAAACCCAAAGAGAGGGAGAGAGACCACT
CGGAATCCCGCAAGGACCTGGCCGCCGACGAGCACAAGGCGAAAGAGGGCCACCTGCCCGAGAAGGACGGGCACGGCCACGAGGGGCGCG
CCGCGGGCGAAGAGGCCAAGCAGCTGGCCCGGGTGCCGTCTCCCTACGTGCGGACCCCGGTGGTGGAGAGTGCCAGGCCCAACAGCACCT
CGAGCCGGGAGGCCGAGCCGCGCAAGGGTGAGCCGGCCTACGAGAACCCCAAGAAGAGCTCCGAGGTCAAGGTGAAGGAGGAGCGGAAGG
AAGACCATGACCTGCCTCCAGAGGCCCCGCAGACCCACCGGGCCTCGGAGCCGCCGCCTCCCAACTCCTCGTCCAGCGTGCACCCGGGGC
CCCTGGCCTCGATGCCCATGACGGTGGGGGTGACGGGCATTCACCCCATGAACAGCATCAGCAGCCTGGACAGGACTCGCATGATGACCC
CCTTCATGGGCATCAGCCCCCTCCCGGGCGGAGAGCGCTTCCCGTACCCTTCTTTCCACTGGGACCCCATCCGGGACCCCTTGAGGGATC
CTTACCGAGAACTTGACATTCACCGGAGAGACCCGCTGGGCAGGGACTTCCTGCTAAGGAACGACCCGCTCCACCGGCTCTCGACTCCCC
GGCTGTACGAAGCCGACCGCTCCTTCAGGGACCGGGAGCCTCACGACTACAGCCACCACCACCACCACCACCACCACCCGCTGTCTGTGG
ACCCTCGGCGGGAGCACGAGCGGGGAGGCCACCTGGACGAGCGGGAGCGCTTGCACATGCTCAGAGAAGACTACGAGCACACGCGGCTCC
ACTCCGTGCACCCCGCCTCCCTCGACGGACACCTCCCCCACCCCAGCCTCATCACCCCGGGACTCCCCAGCATGCACTATCCCCGCATCA
GCCCCACCGCGGGCAACCAGAACGGACTCCTCAACAAGACCCCTCCGACAGCAGCGCTGAGCGCACCTCCCCCGCTCATCTCCACGCTGG
GGGGCCGCCCGGTCTCTCCCAGAAGGACGACTCCTCTGTCCGCAGAGATAAGGGAGAGGCCCCCTTCCCACACGCTGAAGGATATCGAGG
CCCGATAAGCCGAGAACAGGAGCAAGAACGAGGAAGAAGAAACCCTAGGCAGACACCAGGCCAGGCTTGAGAGACAGAACTCCTGCATGG
CTCACACAGACTGGGGGGGAAAGCCCCACCCCTTCCCCTTGTAAAAAATGTATAGACTCAGTGCACATTTTGAAATGTTTTGTATATTAT
ATGTTGAGATTTTTCAGATCTTTTAGCCCAGTCATATGTTCTCACGTCTCCTACTTTTTGTTTCTCGTATAAAACTTTTTGATTTGAACC
AAAACAGTGAAGATGACAACACACACCAATTGGATGATAATTGTAGCGGGGGCGGTGGGGGGGAGAAGTCCACGCCATCCATCATGCAAA
ATTCTTTCAGATGAGGTGGGAAGGCCGTGTACATAGTTATGTAAAAAGAGATTGCTTCATGAGCTAATGGTTCATATATGCAAAAGGGTA
AGATGAAAGCTTTACTTTGTACAAATGTAAATAGATAAAGTAACATAATACATTAATACTTCTTAAAATGTGCTATTTGCAAACTTACTT
AATATCAGTGAACACAGTCGGCTAAAGCTGTGTTCCCATATATTGTTATAGACAGCTAAACCCTTCAACTATGCAATGAATGTTCGGGCT
TTTCACAAAAGCCCGCCTAACTCAAAGGAGCCTTTTCAAATCCATTTACAGCATACTTAAGGTCATATTTTCCCTGAACAAGCGCTTACG
TGATATGACTCTGTTTTCCTTGCTTGTTTTTTTTCAAACGGAGAAACATCCTGTTTTGCAAATTGGACCCCAGGCTGGAACTTAGCATCT
GAAGTTGCCGCTTGTGGGCTCTGGGGGAAAGTGTAGCCCCGGAGAGGTAACTGAGGACATGAGCAACCAGTGCCAGGGAGGGTGGGATTT
GCCAGATGCCAAAATCAGGGGACGGGTGGTGGTGTCTGTCAGACACACACAGGTCGCCAGTGACTTCACACACACCTCATGTGAGAACCA
TGCCTTTTTTAGTGTGTCCTATTTCATACCTGTACACACTTCCTCGTTTTGTAATGAGATTTACTTACACCCAAACAGATCCTGAAAGAA
AGCTTCAAGTTTTCTCAGATGATGGATATGTTTTCACTGTATTCAATAACTGACGGATGTAAGGTGCACGTTTCCTGATGTGACGCACTG
TATTCCAGCTGGTGATCAAGTCTGGGAACAGCCGTAACAGGTCAACCTTGTGGAGCCATCGCGAGTTAGAGGGTGAAAGATGGCAGAAAA
AAAAGTCTTGTGTGTGAGTGTGTTTTTTGAGTTTGCATCAATCTTAATGTCTCTTCATAATACTTTTATAATACATTAAGCCTCTTGTCT
ACATATTTGGAGAGAATATGACTTTACTAGCAGAGAAATACAATATATCTTGTCTACTGGACTGTAAAATATATGTATGAAATAAAATTA

>43235_43235_4_KMT2C-AUTS2_KMT2C_chr7_152132711_ENST00000355193_AUTS2_chr7_69900738_ENST00000406775_length(amino acids)=912AA_BP=
MVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPA
KTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGSTYSEQDILRQELNTRFL
ASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPM
IPPTGPFGSLQGAFQPKLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLAR
PSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLH
RTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREK
DKPKERERDHSESRKDLAADEHKAKEGHLPEKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKGEPAYENPKKS
SEVKVKEERKEDHDLPPEAPQTHRASEPPPPNSSSSVHPGPLASMPMTVGVTGIHPMNSISSLDRTRMMTPFMGISPLPGGERFPYPSFH
WDPIRDPLRDPYRELDIHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLSVDPRREHERGGHLDERERLHM
LREDYEHTRLHSVHPASLDGHLPHPSLITPGLPSMHYPRISPTAGNQNGLLNKTPPTAALSAPPPLISTLGGRPVSPRRTTPLSAEIRER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KMT2C-AUTS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2C-AUTS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2C-AUTS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource