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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANAPC7-UBE2D3 (FusionGDB2 ID:4324)

Fusion Gene Summary for ANAPC7-UBE2D3

check button Fusion gene summary
Fusion gene informationFusion gene name: ANAPC7-UBE2D3
Fusion gene ID: 4324
HgeneTgene
Gene symbol

ANAPC7

UBE2D3

Gene ID

51434

7323

Gene nameanaphase promoting complex subunit 7ubiquitin conjugating enzyme E2 D3
SynonymsAPC7E2(17)KB3|UBC4/5|UBCH5C
Cytomap

12q24.11

4q24

Type of geneprotein-codingprotein-coding
Descriptionanaphase-promoting complex subunit 7cyclosome subunit 7ubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme
Modification date2020031320200313
UniProtAcc

Q9UJX3

.
Ensembl transtripts involved in fusion geneENST00000450008, ENST00000455511, 
ENST00000481473, 		ENST00000321805, 
ENST00000338145, ENST00000343106, 
ENST00000349311, ENST00000350435, 
ENST00000394801, ENST00000394803, 
ENST00000394804, ENST00000453744, 
ENST00000357194, ENST00000502404, 
ENST00000504211, ENST00000505207, 
ENST00000507845, ENST00000513098, 
Fusion gene scores* DoF score20 X 12 X 4=9608 X 5 X 7=280
# samples 219
** MAII scorelog2(21/960*10)=-2.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANAPC7 [Title/Abstract] AND UBE2D3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANAPC7(110825269)-UBE2D3(103718438), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANAPC7

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneUBE2D3

GO:0000209

protein polyubiquitination

14765125|16522193

TgeneUBE2D3

GO:0006513

protein monoubiquitination

20347421

TgeneUBE2D3

GO:0016567

protein ubiquitination

9990509|21532592

TgeneUBE2D3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneUBE2D3

GO:0051865

protein autoubiquitination

21068390

TgeneUBE2D3

GO:0070936

protein K48-linked ubiquitination

20061386

TgeneUBE2D3

GO:0070979

protein K11-linked ubiquitination

20061386


check buttonFusion gene breakpoints across ANAPC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBE2D3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA169456ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-


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Fusion Gene ORF analysis for ANAPC7-UBE2D3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000450008ENST00000321805ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000338145ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000343106ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000349311ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000350435ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000394801ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000394803ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000394804ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000450008ENST00000453744ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000321805ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000338145ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000343106ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000349311ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000350435ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000394801ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000394803ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000394804ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000455511ENST00000453744ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000321805ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000338145ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000343106ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000349311ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000350435ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000394801ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000394803ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000394804ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-3UTRENST00000481473ENST00000453744ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000450008ENST00000357194ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000450008ENST00000502404ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000450008ENST00000504211ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000450008ENST00000505207ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000450008ENST00000507845ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000450008ENST00000513098ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000455511ENST00000357194ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000455511ENST00000502404ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000455511ENST00000504211ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000455511ENST00000505207ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000455511ENST00000507845ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000455511ENST00000513098ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000481473ENST00000357194ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000481473ENST00000502404ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000481473ENST00000504211ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000481473ENST00000505207ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000481473ENST00000507845ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-
intron-intronENST00000481473ENST00000513098ANAPC7chr12

110825269

+UBE2D3chr4

103718438

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANAPC7-UBE2D3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANAPC7-UBE2D3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:110825269/:103718438)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANAPC7

Q9UJX3

.
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANAPC7-UBE2D3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANAPC7-UBE2D3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANAPC7-UBE2D3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANAPC7-UBE2D3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource