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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2C-DENND2A (FusionGDB2 ID:43241)

Fusion Gene Summary for KMT2C-DENND2A

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C-DENND2A
Fusion gene ID: 43241
HgeneTgene
Gene symbol

KMT2C

DENND2A

Gene ID

58508

27147

Gene namelysine methyltransferase 2CDENN domain containing 2A
SynonymsHALR|KLEFS2|MLL3FAM31D|KIAA1277
Cytomap

7q36.1

7q34

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage leDENN domain-containing protein 2ADENN/MADD domain containing 2A
Modification date2020032020200313
UniProtAcc

Q8NEZ4

Q9ULE3

Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000275884, ENST00000492720, 
ENST00000496613, ENST00000537639, 
Fusion gene scores* DoF score26 X 23 X 12=71769 X 7 X 8=504
# samples 3211
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2C [Title/Abstract] AND DENND2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2C(152132711)-DENND2A(140255513), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A2D2-01AKMT2Cchr7

152132711

-DENND2Achr7

140255513

-


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Fusion Gene ORF analysis for KMT2C-DENND2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262189ENST00000275884KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000262189ENST00000492720KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000262189ENST00000496613KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000262189ENST00000537639KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000355193ENST00000275884KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000355193ENST00000492720KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000355193ENST00000496613KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
In-frameENST00000355193ENST00000537639KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485241ENST00000275884KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485241ENST00000492720KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485241ENST00000496613KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485241ENST00000537639KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485655ENST00000275884KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485655ENST00000492720KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485655ENST00000496613KMT2Cchr7

152132711

-DENND2Achr7

140255513

-
intron-3CDSENST00000485655ENST00000537639KMT2Cchr7

152132711

-DENND2Achr7

140255513

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262189KMT2Cchr7152132711-ENST00000275884DENND2Achr7140255513-17383804311450339
ENST00000262189KMT2Cchr7152132711-ENST00000537639DENND2Achr7140255513-17283804311450339
ENST00000262189KMT2Cchr7152132711-ENST00000496613DENND2Achr7140255513-16943804311450339
ENST00000262189KMT2Cchr7152132711-ENST00000492720DENND2Achr7140255513-17883801457744237
ENST00000355193KMT2Cchr7152132711-ENST00000275884DENND2Achr7140255513-17383804311450339
ENST00000355193KMT2Cchr7152132711-ENST00000537639DENND2Achr7140255513-17283804311450339
ENST00000355193KMT2Cchr7152132711-ENST00000496613DENND2Achr7140255513-16943804311450339
ENST00000355193KMT2Cchr7152132711-ENST00000492720DENND2Achr7140255513-17883801457744237

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000275884KMT2Cchr7152132711-DENND2Achr7140255513-0.0186056740.9813943
ENST00000262189ENST00000537639KMT2Cchr7152132711-DENND2Achr7140255513-0.018838990.98116106
ENST00000262189ENST00000496613KMT2Cchr7152132711-DENND2Achr7140255513-0.0192586690.9807413
ENST00000262189ENST00000492720KMT2Cchr7152132711-DENND2Achr7140255513-0.208997370.79100263
ENST00000355193ENST00000275884KMT2Cchr7152132711-DENND2Achr7140255513-0.0186056740.9813943
ENST00000355193ENST00000537639KMT2Cchr7152132711-DENND2Achr7140255513-0.018838990.98116106
ENST00000355193ENST00000496613KMT2Cchr7152132711-DENND2Achr7140255513-0.0192586690.9807413
ENST00000355193ENST00000492720KMT2Cchr7152132711-DENND2Achr7140255513-0.208997370.79100263

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Fusion Genomic Features for KMT2C-DENND2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KMT2C-DENND2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:152132711/chr7:140255513)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

DENND2A

Q9ULE3

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-15934_46534912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-16034_46534969.0DNA bindingNote=A.T hook
TgeneDENND2Achr7:152132711chr7:140255513ENST00000275884919737_8706531010.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000275884919872_9696531010.0DomaindDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000492720913737_870653796.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000492720913872_969653796.0DomaindDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST000004966131020737_8706531010.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST000004966131020872_9696531010.0DomaindDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000537639818737_8706531010.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000537639818872_9696531010.0DomaindDENN

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591338_1366534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591754_1787534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593054_3081534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593173_3272534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593391_3433534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159644_672534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-15992_112534912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601338_1366534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601754_1787534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603054_3081534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603173_3272534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603391_3433534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160644_672534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-16092_112534969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591719_1796534912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591834_2281534912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1592412_2630534912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1592690_2786534912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593012_3509534912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593277_3381534912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601719_1796534969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601834_2281534969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1602412_2630534969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1602690_2786534969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603012_3509534969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603277_3381534969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159436_489534912.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594545_4605534912.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594606_4691534912.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594771_4887534912.0DomainSET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594895_4911534912.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160436_489534969.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604545_4605534969.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604606_4691534969.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604771_4887534969.0DomainSET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604895_4911534969.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594848_4849534912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604848_4849534969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591007_1057534912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591084_1139534912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159227_262534912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159283_331534912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159341_391534912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159344_389534912.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159388_438534912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594399_4439534912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594460_4507534912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159464_520534912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159957_1010534912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601007_1057534969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601084_1139534969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160227_262534969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160283_331534969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160341_391534969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160344_389534969.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160388_438534969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604399_4439534969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604460_4507534969.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160464_520534969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160957_1010534969.0Zinc fingerPHD-type 5
TgeneDENND2Achr7:152132711chr7:140255513ENST00000275884919566_7156531010.0DomainuDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000492720913566_715653796.0DomainuDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST000004966131020566_7156531010.0DomainuDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000537639818566_7156531010.0DomainuDENN


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Fusion Gene Sequence for KMT2C-DENND2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43241_43241_1_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000275884_length(transcript)=1738nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGCATCCTGTCCAAGTGCTGCCACGCGATGGTGGCGCTGATCTACCCCTTCGCCTGGCAGCACA
CCTACATCCCGGTGCTGCCACCCGCCATGGTCGACATCGTGTGCTCGCCGACGCCCTTCCTCATCGGGCTGCTCTCCAGCTCGCTGCCAC
TGCTCAGGGAGCTGCCGCTGGAAGAGGTCCTTGTGGTTGACCTCGTCAACAGCCGGTTCCTCAGACAGATGGACGATGAGGACTCCATCC
TGCCCCGGAAGCTTCAGGTGGCCCTGGAACACATTCTGGAACAGAGGAACGAGCTGGCTTGTGAGCAGGACGAAGGGCCCCTAGACGGCA
GGCACGGTCCAGAGTCCAGCCCCTTGAACGAGGTGGTGTCTGAAGCCTTTGTCCGCTTCTTCGTGGAGATTGTGGGACACTACTCTTTGT
TCCTGACGTCGGGCGAGCGTGAGGAGAGAACCCTGCAGCGGGAGGCCTTCCGCAAAGCTGTCTCCTCCAAGAGCCTCCGCCACTTCCTGG
AGGTCTTCATGGAGACTCAGATGTTTCGGGGCTTCATCCAGGAGCGGGAGCTGCGCCGGCAGGATGCCAAAGGTCTGTTTGAGGTCCGAG
CCCAAGAGTATCTGGAAACACTCCCCAGTGGAGAGCACAGCGGTGTCAATAAGTTCCTGAAGGGACTAGGCAATAAAATGAAATTTCTCC
ACAAGAAATAACTCTCAGCCTCAAGGGAAAACTTCCTCCTAGTGCAGCCCTATGCTTTAAAAACAGTTCCTGGTGGCCTTTCTGAAAGGC
TGGGTCCCAGGTTGTCACGGTGCGGAACTGGAGGCCGCGGTGGCTTCTGGCCGAGGCTGGGCTCTTCCCTGGATGAGGACCTGGGAGCCG
CCTGGGAGGACAGCCCCAGAAAGGGAGCCCGAGACCAGGCGTGTCGCCGACATGCAAATGGGTTGTTTTGGTGGTTGGGTTTTTTTTTTT

>43241_43241_1_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000275884_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------
>43241_43241_2_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000492720_length(transcript)=1788nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGGTACCCGCCTTGGCTACTTCTGCTAAAGCGTTTGAATGACAGTCGCTCTTGGACCCTCTAGT
CTGTAGAGCAGGTGACCGCCTAGCATTGAAGAGTAAGCCCTTCTGAGATAAGGATGGAATAGGCTGGGCGCGGTGACTCACACCTGTAAT
CTCAGCACTTTGAGAGGCTGAGGTGGGTGGATCACTTGAGACCAGGAGTTCGAGGCCAGCCTGTGCAACATGGTGAAACTCCGTCTCTAC
TAAAAATAGAAAAATTAGCCAGCCATGGTGGCCCACGCTTGTTATCCCAGCTACTTGGGAGGCTGAGGCACGGGAATCGATTGAACCTGG
GAGGTGGACATTGCAGTGAGCTGAGATCTCACCACTGCACTCCAGCTTGGGCAACAGAGGGAGACCTTCCCTCCTGCCCCCACAAATAAA
GGATGGCCAGGCACGGTGGCTCATGCCTGTAATCCTAGCACTTCGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACC
AGCCTGGCCAACATGATGAAACTCAGTCTCTACTAAAGATACAAAAATCAGCCAGTCATGGTGGCTCGTGCTTGTAACACCAGCTACTTG
AGAGGCTGAGGTACAAGAATCGCTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCTGAGATCGCACCATTGCACTCCAGCCTGAGCAACAG
AATGACATTCCATCTCAAAAATAAAAATAAAATAGGCCAGGCGCAGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGG
TGGATCACAAGGTCAAGAGATTGAGACCATCCTGGCCAACATGGTGAAACTCCGTCTCTGCTAAAAATACAAAAATTAGCTGGGCATGGT
GGCGTGTGCCTGTAGTCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCA

>43241_43241_2_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000492720_length(amino acids)=237AA_BP=
MRWNVILLLRLECNGAISAHCSLCLLGSSDSCTSASQVAGVTSTSHHDWLIFVSLVETEFHHVGQAGLELLTSGDPPASASRSARITGMS
HRAWPSFICGGRREGLPLLPKLECSGEISAHCNVHLPGSIDSRASASQVAGITSVGHHGWLIFLFLVETEFHHVAQAGLELLVSSDPPTS

--------------------------------------------------------------
>43241_43241_3_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000496613_length(transcript)=1694nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGCATCCTGTCCAAGTGCTGCCACGCGATGGTGGCGCTGATCTACCCCTTCGCCTGGCAGCACA
CCTACATCCCGGTGCTGCCACCCGCCATGGTCGACATCGTGTGCTCGCCGACGCCCTTCCTCATCGGGCTGCTCTCCAGCTCGCTGCCAC
TGCTCAGGGAGCTGCCGCTGGAAGAGGTCCTTGTGGTTGACCTCGTCAACAGCCGGTTCCTCAGACAGATGGACGATGAGGACTCCATCC
TGCCCCGGAAGCTTCAGGTGGCCCTGGAACACATTCTGGAACAGAGGAACGAGCTGGCTTGTGAGCAGGACGAAGGGCCCCTAGACGGCA
GGCACGGTCCAGAGTCCAGCCCCTTGAACGAGGTGGTGTCTGAAGCCTTTGTCCGCTTCTTCGTGGAGATTGTGGGACACTACTCTTTGT
TCCTGACGTCGGGCGAGCGTGAGGAGAGAACCCTGCAGCGGGAGGCCTTCCGCAAAGCTGTCTCCTCCAAGAGCCTCCGCCACTTCCTGG
AGGTCTTCATGGAGACTCAGATGTTTCGGGGCTTCATCCAGGAGCGGGAGCTGCGCCGGCAGGATGCCAAAGGTCTGTTTGAGGTCCGAG
CCCAAGAGTATCTGGAAACACTCCCCAGTGGAGAGCACAGCGGTGTCAATAAGTTCCTGAAGGGACTAGGCAATAAAATGAAATTTCTCC
ACAAGAAATAACTCTCAGCCTCAAGGGAAAACTTCCTCCTAGTGCAGCCCTATGCTTTAAAAACAGTTCCTGGTGGCCTTTCTGAAAGGC
TGGGTCCCAGGTTGTCACGGTGCGGAACTGGAGGCCGCGGTGGCTTCTGGCCGAGGCTGGGCTCTTCCCTGGATGAGGACCTGGGAGCCG

>43241_43241_3_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000496613_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------
>43241_43241_4_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000537639_length(transcript)=1728nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGCATCCTGTCCAAGTGCTGCCACGCGATGGTGGCGCTGATCTACCCCTTCGCCTGGCAGCACA
CCTACATCCCGGTGCTGCCACCCGCCATGGTCGACATCGTGTGCTCGCCGACGCCCTTCCTCATCGGGCTGCTCTCCAGCTCGCTGCCAC
TGCTCAGGGAGCTGCCGCTGGAAGAGGTCCTTGTGGTTGACCTCGTCAACAGCCGGTTCCTCAGACAGATGGACGATGAGGACTCCATCC
TGCCCCGGAAGCTTCAGGTGGCCCTGGAACACATTCTGGAACAGAGGAACGAGCTGGCTTGTGAGCAGGACGAAGGGCCCCTAGACGGCA
GGCACGGTCCAGAGTCCAGCCCCTTGAACGAGGTGGTGTCTGAAGCCTTTGTCCGCTTCTTCGTGGAGATTGTGGGACACTACTCTTTGT
TCCTGACGTCGGGCGAGCGTGAGGAGAGAACCCTGCAGCGGGAGGCCTTCCGCAAAGCTGTCTCCTCCAAGAGCCTCCGCCACTTCCTGG
AGGTCTTCATGGAGACTCAGATGTTTCGGGGCTTCATCCAGGAGCGGGAGCTGCGCCGGCAGGATGCCAAAGGTCTGTTTGAGGTCCGAG
CCCAAGAGTATCTGGAAACACTCCCCAGTGGAGAGCACAGCGGTGTCAATAAGTTCCTGAAGGGACTAGGCAATAAAATGAAATTTCTCC
ACAAGAAATAACTCTCAGCCTCAAGGGAAAACTTCCTCCTAGTGCAGCCCTATGCTTTAAAAACAGTTCCTGGTGGCCTTTCTGAAAGGC
TGGGTCCCAGGTTGTCACGGTGCGGAACTGGAGGCCGCGGTGGCTTCTGGCCGAGGCTGGGCTCTTCCCTGGATGAGGACCTGGGAGCCG
CCTGGGAGGACAGCCCCAGAAAGGGAGCCCGAGACCAGGCGTGTCGCCGACATGCAAATGGGTTGTTTTGGTGGTTGGGTTTTTTTTTTT

>43241_43241_4_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000537639_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------
>43241_43241_5_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000275884_length(transcript)=1738nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGCATCCTGTCCAAGTGCTGCCACGCGATGGTGGCGCTGATCTACCCCTTCGCCTGGCAGCACA
CCTACATCCCGGTGCTGCCACCCGCCATGGTCGACATCGTGTGCTCGCCGACGCCCTTCCTCATCGGGCTGCTCTCCAGCTCGCTGCCAC
TGCTCAGGGAGCTGCCGCTGGAAGAGGTCCTTGTGGTTGACCTCGTCAACAGCCGGTTCCTCAGACAGATGGACGATGAGGACTCCATCC
TGCCCCGGAAGCTTCAGGTGGCCCTGGAACACATTCTGGAACAGAGGAACGAGCTGGCTTGTGAGCAGGACGAAGGGCCCCTAGACGGCA
GGCACGGTCCAGAGTCCAGCCCCTTGAACGAGGTGGTGTCTGAAGCCTTTGTCCGCTTCTTCGTGGAGATTGTGGGACACTACTCTTTGT
TCCTGACGTCGGGCGAGCGTGAGGAGAGAACCCTGCAGCGGGAGGCCTTCCGCAAAGCTGTCTCCTCCAAGAGCCTCCGCCACTTCCTGG
AGGTCTTCATGGAGACTCAGATGTTTCGGGGCTTCATCCAGGAGCGGGAGCTGCGCCGGCAGGATGCCAAAGGTCTGTTTGAGGTCCGAG
CCCAAGAGTATCTGGAAACACTCCCCAGTGGAGAGCACAGCGGTGTCAATAAGTTCCTGAAGGGACTAGGCAATAAAATGAAATTTCTCC
ACAAGAAATAACTCTCAGCCTCAAGGGAAAACTTCCTCCTAGTGCAGCCCTATGCTTTAAAAACAGTTCCTGGTGGCCTTTCTGAAAGGC
TGGGTCCCAGGTTGTCACGGTGCGGAACTGGAGGCCGCGGTGGCTTCTGGCCGAGGCTGGGCTCTTCCCTGGATGAGGACCTGGGAGCCG
CCTGGGAGGACAGCCCCAGAAAGGGAGCCCGAGACCAGGCGTGTCGCCGACATGCAAATGGGTTGTTTTGGTGGTTGGGTTTTTTTTTTT

>43241_43241_5_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000275884_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------
>43241_43241_6_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000492720_length(transcript)=1788nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGGTACCCGCCTTGGCTACTTCTGCTAAAGCGTTTGAATGACAGTCGCTCTTGGACCCTCTAGT
CTGTAGAGCAGGTGACCGCCTAGCATTGAAGAGTAAGCCCTTCTGAGATAAGGATGGAATAGGCTGGGCGCGGTGACTCACACCTGTAAT
CTCAGCACTTTGAGAGGCTGAGGTGGGTGGATCACTTGAGACCAGGAGTTCGAGGCCAGCCTGTGCAACATGGTGAAACTCCGTCTCTAC
TAAAAATAGAAAAATTAGCCAGCCATGGTGGCCCACGCTTGTTATCCCAGCTACTTGGGAGGCTGAGGCACGGGAATCGATTGAACCTGG
GAGGTGGACATTGCAGTGAGCTGAGATCTCACCACTGCACTCCAGCTTGGGCAACAGAGGGAGACCTTCCCTCCTGCCCCCACAAATAAA
GGATGGCCAGGCACGGTGGCTCATGCCTGTAATCCTAGCACTTCGGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACC
AGCCTGGCCAACATGATGAAACTCAGTCTCTACTAAAGATACAAAAATCAGCCAGTCATGGTGGCTCGTGCTTGTAACACCAGCTACTTG
AGAGGCTGAGGTACAAGAATCGCTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCTGAGATCGCACCATTGCACTCCAGCCTGAGCAACAG
AATGACATTCCATCTCAAAAATAAAAATAAAATAGGCCAGGCGCAGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGG
TGGATCACAAGGTCAAGAGATTGAGACCATCCTGGCCAACATGGTGAAACTCCGTCTCTGCTAAAAATACAAAAATTAGCTGGGCATGGT
GGCGTGTGCCTGTAGTCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCA

>43241_43241_6_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000492720_length(amino acids)=237AA_BP=
MRWNVILLLRLECNGAISAHCSLCLLGSSDSCTSASQVAGVTSTSHHDWLIFVSLVETEFHHVGQAGLELLTSGDPPASASRSARITGMS
HRAWPSFICGGRREGLPLLPKLECSGEISAHCNVHLPGSIDSRASASQVAGITSVGHHGWLIFLFLVETEFHHVAQAGLELLVSSDPPTS

--------------------------------------------------------------
>43241_43241_7_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000496613_length(transcript)=1694nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGCATCCTGTCCAAGTGCTGCCACGCGATGGTGGCGCTGATCTACCCCTTCGCCTGGCAGCACA
CCTACATCCCGGTGCTGCCACCCGCCATGGTCGACATCGTGTGCTCGCCGACGCCCTTCCTCATCGGGCTGCTCTCCAGCTCGCTGCCAC
TGCTCAGGGAGCTGCCGCTGGAAGAGGTCCTTGTGGTTGACCTCGTCAACAGCCGGTTCCTCAGACAGATGGACGATGAGGACTCCATCC
TGCCCCGGAAGCTTCAGGTGGCCCTGGAACACATTCTGGAACAGAGGAACGAGCTGGCTTGTGAGCAGGACGAAGGGCCCCTAGACGGCA
GGCACGGTCCAGAGTCCAGCCCCTTGAACGAGGTGGTGTCTGAAGCCTTTGTCCGCTTCTTCGTGGAGATTGTGGGACACTACTCTTTGT
TCCTGACGTCGGGCGAGCGTGAGGAGAGAACCCTGCAGCGGGAGGCCTTCCGCAAAGCTGTCTCCTCCAAGAGCCTCCGCCACTTCCTGG
AGGTCTTCATGGAGACTCAGATGTTTCGGGGCTTCATCCAGGAGCGGGAGCTGCGCCGGCAGGATGCCAAAGGTCTGTTTGAGGTCCGAG
CCCAAGAGTATCTGGAAACACTCCCCAGTGGAGAGCACAGCGGTGTCAATAAGTTCCTGAAGGGACTAGGCAATAAAATGAAATTTCTCC
ACAAGAAATAACTCTCAGCCTCAAGGGAAAACTTCCTCCTAGTGCAGCCCTATGCTTTAAAAACAGTTCCTGGTGGCCTTTCTGAAAGGC
TGGGTCCCAGGTTGTCACGGTGCGGAACTGGAGGCCGCGGTGGCTTCTGGCCGAGGCTGGGCTCTTCCCTGGATGAGGACCTGGGAGCCG

>43241_43241_7_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000496613_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------
>43241_43241_8_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000537639_length(transcript)=1728nt_BP=380nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAACCTGGAGGCAAAGGGAAGCGCCTTCCTGAAGTTTACTGCATTGTGAGCCGCCTGGGATGCTTCAGCCTCT
TTTCAAGGATCTTGGATGAGGTGGAAAAAAGACGAGGCATCTCTCCTGCCCTGGTTCAGCCACTCATGAGAAGTGTCATGGAAGCCCCTT
TCCCAGCCCTGGGCAAAACCATCCTTGTCAAGAACTTCCTGCCAGGTTCAGGAACTGAGGTGATCGAACTGTGCCGCCCGCTGGACTCCC
GGCTCGAGCACGTGGACTTTGAGTCTCTCTTCTCCTCCCTCAGCGTCCGCCACCTGGTCTGTGTGTTTGCCTCCCTGCTTCTGGAGAGGA
GGGTCATCTTCATTGCAGACAAGCTCAGCATCCTGTCCAAGTGCTGCCACGCGATGGTGGCGCTGATCTACCCCTTCGCCTGGCAGCACA
CCTACATCCCGGTGCTGCCACCCGCCATGGTCGACATCGTGTGCTCGCCGACGCCCTTCCTCATCGGGCTGCTCTCCAGCTCGCTGCCAC
TGCTCAGGGAGCTGCCGCTGGAAGAGGTCCTTGTGGTTGACCTCGTCAACAGCCGGTTCCTCAGACAGATGGACGATGAGGACTCCATCC
TGCCCCGGAAGCTTCAGGTGGCCCTGGAACACATTCTGGAACAGAGGAACGAGCTGGCTTGTGAGCAGGACGAAGGGCCCCTAGACGGCA
GGCACGGTCCAGAGTCCAGCCCCTTGAACGAGGTGGTGTCTGAAGCCTTTGTCCGCTTCTTCGTGGAGATTGTGGGACACTACTCTTTGT
TCCTGACGTCGGGCGAGCGTGAGGAGAGAACCCTGCAGCGGGAGGCCTTCCGCAAAGCTGTCTCCTCCAAGAGCCTCCGCCACTTCCTGG
AGGTCTTCATGGAGACTCAGATGTTTCGGGGCTTCATCCAGGAGCGGGAGCTGCGCCGGCAGGATGCCAAAGGTCTGTTTGAGGTCCGAG
CCCAAGAGTATCTGGAAACACTCCCCAGTGGAGAGCACAGCGGTGTCAATAAGTTCCTGAAGGGACTAGGCAATAAAATGAAATTTCTCC
ACAAGAAATAACTCTCAGCCTCAAGGGAAAACTTCCTCCTAGTGCAGCCCTATGCTTTAAAAACAGTTCCTGGTGGCCTTTCTGAAAGGC
TGGGTCCCAGGTTGTCACGGTGCGGAACTGGAGGCCGCGGTGGCTTCTGGCCGAGGCTGGGCTCTTCCCTGGATGAGGACCTGGGAGCCG
CCTGGGAGGACAGCCCCAGAAAGGGAGCCCGAGACCAGGCGTGTCGCCGACATGCAAATGGGTTGTTTTGGTGGTTGGGTTTTTTTTTTT

>43241_43241_8_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000537639_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KMT2C-DENND2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2C-DENND2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2C-DENND2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource