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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2C-DPP6 (FusionGDB2 ID:43243)

Fusion Gene Summary for KMT2C-DPP6

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C-DPP6
Fusion gene ID: 43243
HgeneTgene
Gene symbol

KMT2C

DPP6

Gene ID

58508

1804

Gene namelysine methyltransferase 2Cdipeptidyl peptidase like 6
SynonymsHALR|KLEFS2|MLL3DPL1|DPPX|MRD33|VF2
Cytomap

7q36.1

7q36.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage ledipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6
Modification date2020032020200313
UniProtAcc

Q8NEZ4

P42658

Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000332007, ENST00000377770, 
ENST00000406326, ENST00000427557, 
ENST00000496611, ENST00000404039, 
Fusion gene scores* DoF score26 X 23 X 12=717617 X 17 X 7=2023
# samples 3219
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/2023*10)=-3.41242499622733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2C [Title/Abstract] AND DPP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2C(151962123)-DPP6(154667616), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722

TgeneDPP6

GO:1901379

regulation of potassium ion transmembrane transport

18364354


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FW-A3I3-06AKMT2Cchr7

151962123

-DPP6chr7

154667616

+


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Fusion Gene ORF analysis for KMT2C-DPP6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262189ENST00000332007KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000262189ENST00000377770KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000262189ENST00000406326KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000262189ENST00000427557KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000262189ENST00000496611KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000355193ENST00000332007KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000355193ENST00000377770KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000355193ENST00000406326KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000355193ENST00000427557KMT2Cchr7

151962123

-DPP6chr7

154667616

+
5CDS-intronENST00000355193ENST00000496611KMT2Cchr7

151962123

-DPP6chr7

154667616

+
In-frameENST00000262189ENST00000404039KMT2Cchr7

151962123

-DPP6chr7

154667616

+
In-frameENST00000355193ENST00000404039KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-3CDSENST00000485241ENST00000404039KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-3CDSENST00000485655ENST00000404039KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485241ENST00000332007KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485241ENST00000377770KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485241ENST00000406326KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485241ENST00000427557KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485241ENST00000496611KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485655ENST00000332007KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485655ENST00000377770KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485655ENST00000406326KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485655ENST00000427557KMT2Cchr7

151962123

-DPP6chr7

154667616

+
intron-intronENST00000485655ENST00000496611KMT2Cchr7

151962123

-DPP6chr7

154667616

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262189KMT2Cchr7151962123-ENST00000404039DPP6chr7154667616+392314032072117636
ENST00000355193KMT2Cchr7151962123-ENST00000404039DPP6chr7154667616+392314032072117636

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000404039KMT2Cchr7151962123-DPP6chr7154667616+0.0011555220.9988445
ENST00000355193ENST00000404039KMT2Cchr7151962123-DPP6chr7154667616+0.0011555220.9988445

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Fusion Genomic Features for KMT2C-DPP6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KMT2Cchr7151962122-DPP6chr7154667615+0.000463350.99953663
KMT2Cchr7151962122-DPP6chr7154667615+0.000463350.99953663

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KMT2C-DPP6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151962123/chr7:154667616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

DPP6

P42658

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-85992_1123944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-86092_1123944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-85934_463944912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-86034_463944969.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859227_2623944912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859283_3313944912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859341_3913944912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859344_3893944912.0Zinc fingerRING-type
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860227_2623944969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860283_3313944969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860341_3913944969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860344_3893944969.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8591338_13663944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8591754_17873944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8593054_30813944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8593173_32723944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8593391_34333944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859644_6723944912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8601338_13663944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8601754_17873944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8603054_30813944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8603173_32723944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8603391_34333944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860644_6723944969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8591719_17963944912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8591834_22813944912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8592412_26303944912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8592690_27863944912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8593012_35093944912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8593277_33813944912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8601719_17963944969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8601834_22813944969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8602412_26303944969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8602690_27863944969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8603012_35093944969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8603277_33813944969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859436_4893944912.0DomainDHHC
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594545_46053944912.0DomainFYR N-terminal
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594606_46913944912.0DomainFYR C-terminal
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594771_48873944912.0DomainSET
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594895_49113944912.0DomainPost-SET
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860436_4893944969.0DomainDHHC
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604545_46053944969.0DomainFYR N-terminal
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604606_46913944969.0DomainFYR C-terminal
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604771_48873944969.0DomainSET
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604895_49113944969.0DomainPost-SET
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594848_48493944912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604848_48493944969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8591007_10573944912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8591084_11393944912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859388_4383944912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594399_44393944912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-8594460_45073944912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859464_5203944912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000262189-859957_10103944912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8601007_10573944969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8601084_11393944969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860388_4383944969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604399_44393944969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-8604460_45073944969.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860464_5203944969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151962123chr7:154667616ENST00000355193-860957_10103944969.0Zinc fingerPHD-type 5
TgeneDPP6chr7:151962123chr7:154667616ENST000003320071826117_865565804.0Topological domainExtracellular
TgeneDPP6chr7:151962123chr7:154667616ENST0000033200718261_95565804.0Topological domainCytoplasmic
TgeneDPP6chr7:151962123chr7:154667616ENST000003777701826117_865627866.0Topological domainExtracellular
TgeneDPP6chr7:151962123chr7:154667616ENST0000037777018261_95627866.0Topological domainCytoplasmic
TgeneDPP6chr7:151962123chr7:154667616ENST00000332007182696_116565804.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP6chr7:151962123chr7:154667616ENST00000377770182696_116627866.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for KMT2C-DPP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43243_43243_1_KMT2C-DPP6_KMT2C_chr7_151962123_ENST00000262189_DPP6_chr7_154667616_ENST00000404039_length(transcript)=3923nt_BP=1403nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAGGATGGCACCCCAGGCAGCCAGAGTGTGGCTGAGAAG
TTCGAGGTGAGCTGGGAGACGGTGATGGTGAGCAGCCACGGCGCGGTGGTGGTAAAGTGTGACGGCCGTGGCAGCGGCTTCCAAGGGACC
AAGCTCCTGCACGAAGTGAGGCGGCGGCTGGGCTTGCTGGAGGAGAAGGACCAGATGGAGGCCGTGCGGACGATGCTGAAGGAGCAGTAC
ATTGACAGGACGCGCGTGGCCGTGTTTGGGAAGGATTACGGTGGCTACCTGAGCACCTACATCCTCCCAGCAAAGGGAGAAAATCAAGGC
CAGACATTCACCTGCGGCTCTGCTCTCTCTCCAATAACAGACTTCAAACTCTATGCCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCAT
GGACTTGACAACAGAGCATACGAGATGACCAAGGTAGCCCATCGAGTCTCCGCGCTGGAAGAACAGCAGTTCCTGATCATTCATCCCACT
GCCGATGAAAAAATTCATTTCCAGCACACAGCAGAACTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAGATTTACCCG
GACGAAAGCCATTACTTTACCAGCTCCAGCCTCAAACAGCATCTGTACCGGTCCATCATCAACTTCTTCGTGGAATGCTTCAGGATCCAG
GACAAACTGCTGACAGTCACAGCGAAAGAGGACGAGGAGGAGGACTAAGCTCAGGTCGCTCTAAGCACAAACGTGGCTCTTTCTACAACC
AGATGCAACCGAGGGATTTCCCTGCCCTCCCTCTTCCCTCGGAGGGGCGGGGCGGGGCGGGGCCGGGTGTTCCATAGCATGTGTGTCTCG
GATGCGGAAGGCAGTTTTGCTTGGGAAACAAGCTCCTTCCCCGGGGTCATCACTCACGGCCTCCATGGCACCAGGGACAACGCTGTCCCC
GCAGCAGCGCCTCCTCCCGGCGCCCGAGAGACCGGCACGCCACGGCCCCTCCCCCAAGGAACAGAGCAAAGGATGGTGGCCGCAGGCCCC
ACGCGAGCCCACAGGACACCGGCCCCTAGATTCCAGCCACCAAGCGGAAGCATGAGACCCGCCCACACTAGCCTCTGTGTTCCCGTTAGG
GACATCACACCCTGTCTCACGTCGCAGTGCCATGGACGCAGCAGTTACAGCACCATTGTTTTAGCAGTGCGTGTTCATATATGGGCTTGC
TACTTCCTGTAATGAGGACGTTCAACATGGTGAGGGGCTACAAGAAAACGCTTTTCTGTACAGAGTCTTACTGTAGCTACGCTAATGGTT
AACCTGATAGAATTAACTCGTATTTTTCTATGGTTTTAACCTGATGCTCCACTGTCTCCGTCATGGGGTTGTTTTGCTGTTTGGGGTTGG
GCCTTGTTTCCCTTTCCTTTCTCCAGTCCACGTGTAGACTTTGCGCTTGATGAAGAAGCAGATCGGAAGTAACTGCTCCCTCCTCAAGGT
TGTCTTCAGACGTCTTGGGGACGTTCCTAAACACTGAGGGGGAAGACAGCCAATAGCACCCATTAAAAGAAATACCTAAATAAAACCTCT
CTCCCACTCAGCTATGCTAGGGCTTGGCTGTAGGTGTGCACTGTCTATTTACATCCGTCCTTACAACCATCCTTGTCCTCCTTGGTACCG
TATCAAGCTCTTTCCCATGACATTTGGTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGAAAAAAGACAAAGCGTCAACTCCACCCAC
AGGCCCGCTGTGTGTGCTCGGGCCACGGGAGTCCTGAGGGTTCTGTGGGCCTGCGCGCATCCCTCTCCCATCGTGGGGGTGGCTCCGTGA
CCTTCCTGCCACGAGCAGGAGGTTGATGATGTGCTACGTTAGCCTTGTAAGATACACCCCCACCAAATGTGCAGCCGGTGTTCCCAGTGT
ATATTTCATTCTCTTGTATATAAAGGAAGCAATGTGTGTCAGGCCTCTGTGCAGTCAACCCAGCCTCCTCCCGCCAGTGCTAACCCCGTG
TTGAGCCTGCATGCTGACACTGTGGCCGATCTGGACTCTAGAAGTGCTAGTTTGAAATATATCCATTACTGTCATTTCCTTTTGAGCTTG
TGGACAAGCTGAATGTCAGGACTGACTTCGCCAGCTCCCAGCCCTGCGGGGGTGTCCTTGGCATCCCATCAGCAGAGGAGATGCGTCCCT
GTTGCATTTTGGCGTTTGGGGCTTTGGGTTTATCCACATGAGCTCTGAACGTCCGTTATAGTTAGGGTGATTGGAAGGTCTCCATCACTG
GGTGTTTTAAAGGTGATTCACCACCATTTGTGAAAGGACCAACGTGCTGATAAACAGGACCGATCCGAGTGCTACATGACTGTGCGTTTG
CTATTTCAATGGGCCTGAACGACTACAAAGCCAGCTAGGTCTGGAAGGGGAAGCCAGCTCTGGCCACGACATCTGGTCGGAGGGAAGTGG

>43243_43243_1_KMT2C-DPP6_KMT2C_chr7_151962123_ENST00000262189_DPP6_chr7_154667616_ENST00000404039_length(amino acids)=636AA_BP=399
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRR
LGLLEEKDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEM
TKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTVTAK

--------------------------------------------------------------
>43243_43243_2_KMT2C-DPP6_KMT2C_chr7_151962123_ENST00000355193_DPP6_chr7_154667616_ENST00000404039_length(transcript)=3923nt_BP=1403nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAGGATGGCACCCCAGGCAGCCAGAGTGTGGCTGAGAAG
TTCGAGGTGAGCTGGGAGACGGTGATGGTGAGCAGCCACGGCGCGGTGGTGGTAAAGTGTGACGGCCGTGGCAGCGGCTTCCAAGGGACC
AAGCTCCTGCACGAAGTGAGGCGGCGGCTGGGCTTGCTGGAGGAGAAGGACCAGATGGAGGCCGTGCGGACGATGCTGAAGGAGCAGTAC
ATTGACAGGACGCGCGTGGCCGTGTTTGGGAAGGATTACGGTGGCTACCTGAGCACCTACATCCTCCCAGCAAAGGGAGAAAATCAAGGC
CAGACATTCACCTGCGGCTCTGCTCTCTCTCCAATAACAGACTTCAAACTCTATGCCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCAT
GGACTTGACAACAGAGCATACGAGATGACCAAGGTAGCCCATCGAGTCTCCGCGCTGGAAGAACAGCAGTTCCTGATCATTCATCCCACT
GCCGATGAAAAAATTCATTTCCAGCACACAGCAGAACTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAGATTTACCCG
GACGAAAGCCATTACTTTACCAGCTCCAGCCTCAAACAGCATCTGTACCGGTCCATCATCAACTTCTTCGTGGAATGCTTCAGGATCCAG
GACAAACTGCTGACAGTCACAGCGAAAGAGGACGAGGAGGAGGACTAAGCTCAGGTCGCTCTAAGCACAAACGTGGCTCTTTCTACAACC
AGATGCAACCGAGGGATTTCCCTGCCCTCCCTCTTCCCTCGGAGGGGCGGGGCGGGGCGGGGCCGGGTGTTCCATAGCATGTGTGTCTCG
GATGCGGAAGGCAGTTTTGCTTGGGAAACAAGCTCCTTCCCCGGGGTCATCACTCACGGCCTCCATGGCACCAGGGACAACGCTGTCCCC
GCAGCAGCGCCTCCTCCCGGCGCCCGAGAGACCGGCACGCCACGGCCCCTCCCCCAAGGAACAGAGCAAAGGATGGTGGCCGCAGGCCCC
ACGCGAGCCCACAGGACACCGGCCCCTAGATTCCAGCCACCAAGCGGAAGCATGAGACCCGCCCACACTAGCCTCTGTGTTCCCGTTAGG
GACATCACACCCTGTCTCACGTCGCAGTGCCATGGACGCAGCAGTTACAGCACCATTGTTTTAGCAGTGCGTGTTCATATATGGGCTTGC
TACTTCCTGTAATGAGGACGTTCAACATGGTGAGGGGCTACAAGAAAACGCTTTTCTGTACAGAGTCTTACTGTAGCTACGCTAATGGTT
AACCTGATAGAATTAACTCGTATTTTTCTATGGTTTTAACCTGATGCTCCACTGTCTCCGTCATGGGGTTGTTTTGCTGTTTGGGGTTGG
GCCTTGTTTCCCTTTCCTTTCTCCAGTCCACGTGTAGACTTTGCGCTTGATGAAGAAGCAGATCGGAAGTAACTGCTCCCTCCTCAAGGT
TGTCTTCAGACGTCTTGGGGACGTTCCTAAACACTGAGGGGGAAGACAGCCAATAGCACCCATTAAAAGAAATACCTAAATAAAACCTCT
CTCCCACTCAGCTATGCTAGGGCTTGGCTGTAGGTGTGCACTGTCTATTTACATCCGTCCTTACAACCATCCTTGTCCTCCTTGGTACCG
TATCAAGCTCTTTCCCATGACATTTGGTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGAAAAAAGACAAAGCGTCAACTCCACCCAC
AGGCCCGCTGTGTGTGCTCGGGCCACGGGAGTCCTGAGGGTTCTGTGGGCCTGCGCGCATCCCTCTCCCATCGTGGGGGTGGCTCCGTGA
CCTTCCTGCCACGAGCAGGAGGTTGATGATGTGCTACGTTAGCCTTGTAAGATACACCCCCACCAAATGTGCAGCCGGTGTTCCCAGTGT
ATATTTCATTCTCTTGTATATAAAGGAAGCAATGTGTGTCAGGCCTCTGTGCAGTCAACCCAGCCTCCTCCCGCCAGTGCTAACCCCGTG
TTGAGCCTGCATGCTGACACTGTGGCCGATCTGGACTCTAGAAGTGCTAGTTTGAAATATATCCATTACTGTCATTTCCTTTTGAGCTTG
TGGACAAGCTGAATGTCAGGACTGACTTCGCCAGCTCCCAGCCCTGCGGGGGTGTCCTTGGCATCCCATCAGCAGAGGAGATGCGTCCCT
GTTGCATTTTGGCGTTTGGGGCTTTGGGTTTATCCACATGAGCTCTGAACGTCCGTTATAGTTAGGGTGATTGGAAGGTCTCCATCACTG
GGTGTTTTAAAGGTGATTCACCACCATTTGTGAAAGGACCAACGTGCTGATAAACAGGACCGATCCGAGTGCTACATGACTGTGCGTTTG
CTATTTCAATGGGCCTGAACGACTACAAAGCCAGCTAGGTCTGGAAGGGGAAGCCAGCTCTGGCCACGACATCTGGTCGGAGGGAAGTGG

>43243_43243_2_KMT2C-DPP6_KMT2C_chr7_151962123_ENST00000355193_DPP6_chr7_154667616_ENST00000404039_length(amino acids)=636AA_BP=399
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRR
LGLLEEKDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEM
TKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTVTAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KMT2C-DPP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2C-DPP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2C-DPP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource