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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2C-PDE8A (FusionGDB2 ID:43257)

Fusion Gene Summary for KMT2C-PDE8A

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2C-PDE8A
Fusion gene ID: 43257
HgeneTgene
Gene symbol

KMT2C

PDE8A

Gene ID

58508

5151

Gene namelysine methyltransferase 2Cphosphodiesterase 8A
SynonymsHALR|KLEFS2|MLL3HsT19550
Cytomap

7q36.1

15q25.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage lehigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AcAMP-specific cyclic nucleotide phosphodiesterase 8A
Modification date2020032020200313
UniProtAcc

Q8NEZ4

.
Ensembl transtripts involved in fusion geneENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000339708, ENST00000394553, 
ENST00000557957, ENST00000557819, 
ENST00000310298, 
Fusion gene scores* DoF score26 X 23 X 12=717610 X 10 X 4=400
# samples 3211
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2C [Title/Abstract] AND PDE8A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2C(151900019)-PDE8A(85607601), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDE8A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AKMT2Cchr7

151900019

-PDE8Achr15

85607601

+


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Fusion Gene ORF analysis for KMT2C-PDE8A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262189ENST00000339708KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-5UTRENST00000262189ENST00000394553KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-5UTRENST00000262189ENST00000557957KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-5UTRENST00000355193ENST00000339708KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-5UTRENST00000355193ENST00000394553KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-5UTRENST00000355193ENST00000557957KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-intronENST00000262189ENST00000557819KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
5CDS-intronENST00000355193ENST00000557819KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
In-frameENST00000262189ENST00000310298KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
In-frameENST00000355193ENST00000310298KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-3CDSENST00000485241ENST00000310298KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-3CDSENST00000485655ENST00000310298KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-5UTRENST00000485241ENST00000339708KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-5UTRENST00000485241ENST00000394553KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-5UTRENST00000485241ENST00000557957KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-5UTRENST00000485655ENST00000339708KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-5UTRENST00000485655ENST00000394553KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-5UTRENST00000485655ENST00000557957KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-intronENST00000485241ENST00000557819KMT2Cchr7

151900019

-PDE8Achr15

85607601

+
intron-intronENST00000485655ENST00000557819KMT2Cchr7

151900019

-PDE8Achr15

85607601

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262189KMT2Cchr7151900019-ENST00000310298PDE8Achr1585607601+7857431120766142135
ENST00000355193KMT2Cchr7151900019-ENST00000310298PDE8Achr1585607601+7857431120766142135

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000310298KMT2Cchr7151900019-PDE8Achr1585607601+0.0005156020.9994844
ENST00000355193ENST00000310298KMT2Cchr7151900019-PDE8Achr1585607601+0.0005156020.9994844

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Fusion Genomic Features for KMT2C-PDE8A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KMT2Cchr7151900018-PDE8Achr1585607600+0.0003208450.9996792
KMT2Cchr7151900018-PDE8Achr1585607600+0.0003208450.9996792

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KMT2C-PDE8A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151900019/chr15:85607601)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

.
FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26591338_136613644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659644_67213644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-265992_11213644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26601338_136613644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660644_67213644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-266092_11213644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-265934_4613644912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-266034_4613644969.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659436_48913644912.0DomainDHHC
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660436_48913644969.0DomainDHHC
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26591007_105713644912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26591084_113913644912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659227_26213644912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659283_33113644912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659341_39113644912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659344_38913644912.0Zinc fingerRING-type
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659388_43813644912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659464_52013644912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-2659957_101013644912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26601007_105713644969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26601084_113913644969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660227_26213644969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660283_33113644969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660341_39113644969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660344_38913644969.0Zinc fingerRING-type
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660388_43813644969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660464_52013644969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-2660957_101013644969.0Zinc fingerPHD-type 5
TgenePDE8Achr7:151900019chr15:85607601ENST00000310298123213_28362830.0DomainPAS
TgenePDE8Achr7:151900019chr15:85607601ENST00000310298123287_32962830.0DomainNote=PAC
TgenePDE8Achr7:151900019chr15:85607601ENST00000310298123480_82062830.0DomainPDEase
TgenePDE8Achr7:151900019chr15:85607601ENST00000339708021213_28362784.0DomainPAS
TgenePDE8Achr7:151900019chr15:85607601ENST00000339708021287_32962784.0DomainNote=PAC
TgenePDE8Achr7:151900019chr15:85607601ENST00000339708021480_82062784.0DomainPDEase
TgenePDE8Achr7:151900019chr15:85607601ENST00000394553022213_28362830.0DomainPAS
TgenePDE8Achr7:151900019chr15:85607601ENST00000394553022287_32962830.0DomainNote=PAC
TgenePDE8Achr7:151900019chr15:85607601ENST00000394553022480_82062830.0DomainPDEase
TgenePDE8Achr7:151900019chr15:85607601ENST00000557957022213_2830758.0DomainPAS
TgenePDE8Achr7:151900019chr15:85607601ENST00000557957022287_3290758.0DomainNote=PAC
TgenePDE8Achr7:151900019chr15:85607601ENST00000557957022480_8200758.0DomainPDEase
TgenePDE8Achr7:151900019chr15:85607601ENST00000310298123454_46162830.0RegionInvolved in RAF1-binding
TgenePDE8Achr7:151900019chr15:85607601ENST00000339708021454_46162784.0RegionInvolved in RAF1-binding
TgenePDE8Achr7:151900019chr15:85607601ENST00000394553022454_46162830.0RegionInvolved in RAF1-binding
TgenePDE8Achr7:151900019chr15:85607601ENST00000557957022454_4610758.0RegionInvolved in RAF1-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26591754_178713644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26593054_308113644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26593173_327213644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26593391_343313644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26601754_178713644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26603054_308113644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26603173_327213644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26603391_343313644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26591719_179613644912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26591834_228113644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26592412_263013644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26592690_278613644912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26593012_350913644912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26593277_338113644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26601719_179613644969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26601834_228113644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26602412_263013644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26602690_278613644969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26603012_350913644969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26603277_338113644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594545_460513644912.0DomainFYR N-terminal
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594606_469113644912.0DomainFYR C-terminal
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594771_488713644912.0DomainSET
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594895_491113644912.0DomainPost-SET
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604545_460513644969.0DomainFYR N-terminal
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604606_469113644969.0DomainFYR C-terminal
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604771_488713644969.0DomainSET
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604895_491113644969.0DomainPost-SET
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594848_484913644912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604848_484913644969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594399_443913644912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000262189-26594460_450713644912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604399_443913644969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151900019chr15:85607601ENST00000355193-26604460_450713644969.0Zinc fingerPHD-type 8


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Fusion Gene Sequence for KMT2C-PDE8A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43257_43257_1_KMT2C-PDE8A_KMT2C_chr7_151900019_ENST00000262189_PDE8A_chr15_85607601_ENST00000310298_length(transcript)=7857nt_BP=4311nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGGCTGGAGTGAGCAGTTACCAGATACTTTAGTTGATGAATCTGTTTCTGTT
ACTGAAAGCACTGAAAAAATAAAGAAGAGATACCGAAAAAGGAAAAATAAGCTTGAAGAAACTTTCCCTGCCTATTTACAAGTAGCAGTA
GCTGATGTGCAGTTTGGCCCCATGAGATTTCATCAAGATCAACTTCAGGTACTTTTAGTGTTTACCAAAGAAGATAACCAATGTAATGGA
TTCTGCAGGGCATGTGAAAAAGCAGGGTTTAAGTGTACAGTTACCAAGGAGGCTCAGGCTGTCCTTGCCTGTTTCCTGGACAAACATCAT
GACATTATCATCATAGACCACAGAAATCCTCGACAGCTGGATGCAGAGGCACTGTGCAGGTCTATCAGATCATCAAAACTCTCAGAAAAC
ACAGTTATTGTTGGTGTAGTACGCAGGGTGGATAGAGAAGAGTTGTCCGTAATGCCTTTCATTTCTGCTGGATTTACAAGGAGGTATGTA
GAAAACCCCAACATCATGGCCTGCTACAATGAACTGCTCCAGCTGGAGTTTGGAGAGGTGCGATCACAACTGAAACTCAGGGCTTGTAAC
TCAGTATTCACTGCATTAGAAAACAGTGAAGATGCAATTGAAATTACAAGCGAAGACCGTTTTATACAGTATGCAAATCCTGCATTTGAA
ACAACAATGGGCTATCAGTCAGGTGAATTAATAGGGAAGGAGTTAGGAGAAGTGCCTATAAATGAAAAAAAGGCTGACTTGCTCGATACT
ATAAATTCATGCATCAGGATAGGCAAGGAGTGGCAAGGAATTTACTATGCCAAAAAGAAAAACGGAGATAATATACAACAAAATGTGAAG
ATAATACCTGTCATTGGACAGGGAGGAAAAATTAGACACTATGTGTCCATTATCAGAGTGTGCAATGGCAACAATAAGGCTGAGAAAATA
TCCGAATGTGTTCAGTCTGACACTCATACAGATAATCAGACAGGCAAACATAAAGACAGGAGAAAAGGCTCACTAGACGTCAAAGCTGTT
GCCTCCCGTGCAACTGAAGTTTCCAGCCAGAGACGACACTCTTCCATGGCCCGGATACATTCCATGACAATTGAGGCGCCCATCACCAAG
GTAATCAATATTATCAATGCTGCCCAGGAAAGTAGTCCCATGCCTGTGACAGAAGCCCTAGACCGTGTGCTGGAAATTCTAAGAACCACT
GAGTTATATTCACCACAGTTTGGTGCTAAAGATGATGATCCCCATGCCAATGACCTTGTTGGGGGCTTAATGTCTGATGGTTTGCGAAGA
CTATCAGGGAATGAATATGTTCTTTCAACAAAAAACACTCAAATGGTTTCAAGCAATATAATCACTCCCATCTCCCTTGATGATGTCCCA
CCACGGATAGCTCGGGCCATGGAAAATGAGGAATACTGGGACTTTGATATTTTTGAACTGGAGGCTGCCACCCACAATAGGCCTTTGATT
TATCTTGGTCTCAAAATGTTTGCTCGCTTTGGAATCTGTGAATTCTTACACTGCTCCGAGTCAACGCTAAGATCATGGTTACAAATTATC
GAAGCCAATTATCATTCCTCCAATCCCTACCACAATTCTACACATTCTGCTGATGTGCTTCATGCCACTGCCTATTTTCTCTCCAAGGAG
AGGATAAAGGAAACTTTAGATCCAATTGATGAGGTCGCTGCACTCATCGCAGCCACCATTCATGATGTGGATCACCCTGGGAGAACCAAC
TCCTTCCTGTGTAATGCTGGAAGTGAGCTGGCCATTTTGTACAATGACACTGCTGTGCTGGAGAGCCACCATGCGGCCTTGGCCTTCCAG
CTGACCACTGGAGATGATAAATGCAATATATTTAAAAACATGGAGAGGAATGATTATCGGACACTGCGCCAGGGGATTATCGACATGGTC
TTAGCCACAGAAATGACAAAGCACTTTGAGCATGTCAACAAATTTGTCAACAGCATCAACAAACCCTTGGCAACACTAGAAGAAAATGGG
GAAACTGATAAAAACCAGGAAGTGATAAACACTATGCTTAGGACTCCAGAGAACCGGACCCTAATCAAACGAATGCTGATTAAATGTGCT
GATGTGTCCAATCCCTGCCGACCCCTGCAGTACTGCATCGAGTGGGCTGCACGCATTTCGGAAGAATATTTTTCTCAGACTGATGAAGAG
AAGCAGCAGGGCTTACCTGTGGTGATGCCAGTGTTTGACAGAAATACCTGCAGCATCCCCAAATCCCAAATCTCTTTCATTGATTACTTC
ATCACAGACATGTTTGATGCTTGGGATGCCTTTGTAGACCTGCCTGATTTAATGCAGCATCTTGACAACAACTTTAAATACTGGAAAGGA
CTGGACGAAATGAAGCTGCGGAACCTCCGACCACCTCCTGAATAGTGGGAGACACCACCCAGAGCCCTGAAGCTTTGTTCCTTCGGTCAT
TTGGAATTCCTGAGGGCAGCCAGAGCTCCTTGGTCCTTTCAGTACTAGGCAGAACAGCCCCCGATCTGCATAGCCTGTGAAAGCCCACGG
GGACATCAGTAACCTTCTGCAGCCACCATCCAATGCCATTACTGTCAAGTGAGACTTGGCCACTGTAGCCTGGGCCTGCTGCAGGAGCTC
TTCAGAAAGGCACATGAGGACCACGGTTTGCCTCAGTTTCTGGTAAAACACAAGGTCTGGAGTGCCCCTGCAAAGGGTATTGATGGACTT
CCTGCCAGTGACAGAGCATGTCTATTGCAAACAATTCTCTCAGTTACGTTCAGCACTTAAGAACGGCTAATGGCAATAGGATCTTTAGCA
ACTTTTTCACATCATAGAAGGTGCAATCGCTCACTTGGGAACACTACTGAGAGTGACTTCTCTTTTAAAATTGAGTAGCAGATGAAAAAT
TAAAATTTGAACTTGATTATTAATATCAATTAAAATGTTTTATTTATTTTATTAAAAGCTCAATATTTTCTATGAATTCAAAAATACTTC
AGAGCCAAAGCCAACTTCAAATACCGTGACCAAATTTACATGATTCATATTCATTATGCATTACTTGGTATACAGACTTATTTTCATAAT
GCAAATTAATAAAATGACACTTTTACTGCACTATAGAAATATTCATGTATGTTAAACTTTTCTGATTGAGGCTAACTGGAAAAAGCTGGG
GTCGTATTCTAAGTGCTAAAGAAGGCTGCTTCTACTGTATAGAACCCAGGGCTCTGAAACAGCTCTAGCCGCCTAATGCACTTCACAGGT
AACTCCCCAAGGTAAAACTAGACTCTCTTGTTGGTTCGCAAAGAAAAGTTAGGACTTAACACTTTTTTCTAAAATTTTATAATTCAATTT
CCAAAAGTCTACTCTATTTTATACTGTTTCTACAAAATATTCCTTATAAAAACAAAGAACAAAAATTGAATATTTAATGAATTGACATTT
TATAACCAACCTGTTTTTATCTACGGTGGGAATCTTTGATGCCAGAAATTTATAAAGAGGTTCTGTATCTTCACACCTTGAATAAGCATA
ATACCATAAAAAATGACACTTGACATGTCAATGTATTTGTCATTTCATTTTAAACTCGTATTTGTGGTTTTTTTCCCAGATAAAAATGAA

>43257_43257_1_KMT2C-PDE8A_KMT2C_chr7_151900019_ENST00000262189_PDE8A_chr15_85607601_ENST00000310298_length(amino acids)=2135AA_BP=1366
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKK
RYRKRKNKLEETFPAYLQVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRN
PRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENS
EDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGG
KIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQ
ESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMEN
EEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPI
DEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHF
EHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVM

--------------------------------------------------------------
>43257_43257_2_KMT2C-PDE8A_KMT2C_chr7_151900019_ENST00000355193_PDE8A_chr15_85607601_ENST00000310298_length(transcript)=7857nt_BP=4311nt
GAGGTGCGCGCGCCCGCGCCGATGTGTGTGAGTGCGTGTCCTGCTCGCTCCATGTTGCCGCCTCTCCCGGTACCTGCTGCTGCTCCCGGG
GCTGCGGGAAATGCGAGAGGCTGAGCCGGGGAGGAGGAACCCGAGCAGCAGCGGCGGCGGCGGCGGCCGCGGCGGCGGGAGCCCCCCAGG
AGGAGGACCGGGATCCATGTGTCTTTCCTGGTGACTAGGATGTCGTCGGAGGAGGACAAGAGCGTGGAGCAGCCGCAGCCGCCGCCACCA
CCCCCCGAGGAGCCTGGAGCCCCGGCCCCGAGCCCCGCAGCCGCAGACAAAAGACCTCGGGGCCGGCCTCGCAAAGATGGCGCTTCCCCT
TTCCAGAGAGCCAGAAAGAAACCTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGGCTGGAGACAACAGAAACA
GAAACGATTGTGGAAACAGAAATCAAAGAACAATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAATTCCAACT
CTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTCTGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGT
TACTGTGGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAACGCCTGGATTTATCTTGCCATGGAGAAACCAACCT
TCTAACAAGAAGGACATTGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCACGAAAACAAAGAGGACAGAGAAAA
GAACGATCTCCTCAGCAGAATATAGTATCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAACTGTGGGATGAA
CTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAAGCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAG
TGGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACAAAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTT
TGTAAGCACCTTGGAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATCCTTGTGCTGCAGGAGCCGGCACCTTT
CAGGATTTCAGTCACATCTTCCTGCTTTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAACTGTGCAGTGTGC
GACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACTACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCA
TTAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCAAACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGAT
ACGTGTGACAAAGGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATGGCTGGAAATGCAAAAATTGCAGAATA
TGTATAGAGTGTGGCACACGGTCTAGTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGCAGGATAACTTATGT
CCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGAAAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTGAC
AAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCTGCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTA
CAGCCAGGTGAGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAAGTTGAAGGCCCTGAAGATCAAATGGTATTC
TCAGAGCAGGCAGCTAATAAAGATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAAGTCCACACTGAAGAGCAA
CAGAAGAGTCATCCCTCAGAAAGTCTTGACACAGATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGGAAAAA
CAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTGAAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATG
GAAGTGACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACAACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTA
TCCAGAGAAGAATCAAGGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGTGTCCCCACATGAGGAAAGTATT
TCATTATGTCCTGAGGAACAGTTGGTTATAGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTACTGGATTGATG
GACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAGATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAG
TCATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCCAACACCTTCTTCAGACTTGCCTTCGCATGACATGCTG
CATAATTACCCTTCAGCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCACTCCAAAAATTGGCATGGGTAAA
CCAGCTATTACTAAGAGAAAATTTTCTCCTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGAGCCCACCTTCC
TGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACCCAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGG
TCTGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAGGTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGA
GCTGTTGTATTACCTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACTCTATGCACAATACAGTTGTGTTGTTT
TCTAGCAGTGACAAGTTCACTTTGAATCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAGATTACTTGCCTGT
TCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGTATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC
ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTGTGTGATGACTGTGACATAAGTTATCACACCTACTGCCTA
GACCCTCCATTGCAGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGACACTGTGGAGCAACATCTGCAGGTCTA
AGATGTGAATGGCAGAACAATTACACACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAACTATAGAGAAGAA
GATCTTATTCTGCAATGTAGACAATGTGATAGATGGATGCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGCA
GACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAATGTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCA
CAAATTGTCACAAAAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTTTGACTGAATCAGGGATGACTCAGTTA
CAGAGCCTCACAGTTACAGTTCCAAGAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAATAGCGTGGCCGTCCTT
CAGACCCCTCCAGACATCCAATCAGAGCATTCAAGGGATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGGAAAA
TCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGGGAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCA
TACAGACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGGGAAAACCAAAAGATCTGTGATCAGAAAAGATTCC
TCAGGCTCTATTTCCGAGCAGTTACCTTGCAGAGATGATGGCTGGAGTGAGCAGTTACCAGATACTTTAGTTGATGAATCTGTTTCTGTT
ACTGAAAGCACTGAAAAAATAAAGAAGAGATACCGAAAAAGGAAAAATAAGCTTGAAGAAACTTTCCCTGCCTATTTACAAGTAGCAGTA
GCTGATGTGCAGTTTGGCCCCATGAGATTTCATCAAGATCAACTTCAGGTACTTTTAGTGTTTACCAAAGAAGATAACCAATGTAATGGA
TTCTGCAGGGCATGTGAAAAAGCAGGGTTTAAGTGTACAGTTACCAAGGAGGCTCAGGCTGTCCTTGCCTGTTTCCTGGACAAACATCAT
GACATTATCATCATAGACCACAGAAATCCTCGACAGCTGGATGCAGAGGCACTGTGCAGGTCTATCAGATCATCAAAACTCTCAGAAAAC
ACAGTTATTGTTGGTGTAGTACGCAGGGTGGATAGAGAAGAGTTGTCCGTAATGCCTTTCATTTCTGCTGGATTTACAAGGAGGTATGTA
GAAAACCCCAACATCATGGCCTGCTACAATGAACTGCTCCAGCTGGAGTTTGGAGAGGTGCGATCACAACTGAAACTCAGGGCTTGTAAC
TCAGTATTCACTGCATTAGAAAACAGTGAAGATGCAATTGAAATTACAAGCGAAGACCGTTTTATACAGTATGCAAATCCTGCATTTGAA
ACAACAATGGGCTATCAGTCAGGTGAATTAATAGGGAAGGAGTTAGGAGAAGTGCCTATAAATGAAAAAAAGGCTGACTTGCTCGATACT
ATAAATTCATGCATCAGGATAGGCAAGGAGTGGCAAGGAATTTACTATGCCAAAAAGAAAAACGGAGATAATATACAACAAAATGTGAAG
ATAATACCTGTCATTGGACAGGGAGGAAAAATTAGACACTATGTGTCCATTATCAGAGTGTGCAATGGCAACAATAAGGCTGAGAAAATA
TCCGAATGTGTTCAGTCTGACACTCATACAGATAATCAGACAGGCAAACATAAAGACAGGAGAAAAGGCTCACTAGACGTCAAAGCTGTT
GCCTCCCGTGCAACTGAAGTTTCCAGCCAGAGACGACACTCTTCCATGGCCCGGATACATTCCATGACAATTGAGGCGCCCATCACCAAG
GTAATCAATATTATCAATGCTGCCCAGGAAAGTAGTCCCATGCCTGTGACAGAAGCCCTAGACCGTGTGCTGGAAATTCTAAGAACCACT
GAGTTATATTCACCACAGTTTGGTGCTAAAGATGATGATCCCCATGCCAATGACCTTGTTGGGGGCTTAATGTCTGATGGTTTGCGAAGA
CTATCAGGGAATGAATATGTTCTTTCAACAAAAAACACTCAAATGGTTTCAAGCAATATAATCACTCCCATCTCCCTTGATGATGTCCCA
CCACGGATAGCTCGGGCCATGGAAAATGAGGAATACTGGGACTTTGATATTTTTGAACTGGAGGCTGCCACCCACAATAGGCCTTTGATT
TATCTTGGTCTCAAAATGTTTGCTCGCTTTGGAATCTGTGAATTCTTACACTGCTCCGAGTCAACGCTAAGATCATGGTTACAAATTATC
GAAGCCAATTATCATTCCTCCAATCCCTACCACAATTCTACACATTCTGCTGATGTGCTTCATGCCACTGCCTATTTTCTCTCCAAGGAG
AGGATAAAGGAAACTTTAGATCCAATTGATGAGGTCGCTGCACTCATCGCAGCCACCATTCATGATGTGGATCACCCTGGGAGAACCAAC
TCCTTCCTGTGTAATGCTGGAAGTGAGCTGGCCATTTTGTACAATGACACTGCTGTGCTGGAGAGCCACCATGCGGCCTTGGCCTTCCAG
CTGACCACTGGAGATGATAAATGCAATATATTTAAAAACATGGAGAGGAATGATTATCGGACACTGCGCCAGGGGATTATCGACATGGTC
TTAGCCACAGAAATGACAAAGCACTTTGAGCATGTCAACAAATTTGTCAACAGCATCAACAAACCCTTGGCAACACTAGAAGAAAATGGG
GAAACTGATAAAAACCAGGAAGTGATAAACACTATGCTTAGGACTCCAGAGAACCGGACCCTAATCAAACGAATGCTGATTAAATGTGCT
GATGTGTCCAATCCCTGCCGACCCCTGCAGTACTGCATCGAGTGGGCTGCACGCATTTCGGAAGAATATTTTTCTCAGACTGATGAAGAG
AAGCAGCAGGGCTTACCTGTGGTGATGCCAGTGTTTGACAGAAATACCTGCAGCATCCCCAAATCCCAAATCTCTTTCATTGATTACTTC
ATCACAGACATGTTTGATGCTTGGGATGCCTTTGTAGACCTGCCTGATTTAATGCAGCATCTTGACAACAACTTTAAATACTGGAAAGGA
CTGGACGAAATGAAGCTGCGGAACCTCCGACCACCTCCTGAATAGTGGGAGACACCACCCAGAGCCCTGAAGCTTTGTTCCTTCGGTCAT
TTGGAATTCCTGAGGGCAGCCAGAGCTCCTTGGTCCTTTCAGTACTAGGCAGAACAGCCCCCGATCTGCATAGCCTGTGAAAGCCCACGG
GGACATCAGTAACCTTCTGCAGCCACCATCCAATGCCATTACTGTCAAGTGAGACTTGGCCACTGTAGCCTGGGCCTGCTGCAGGAGCTC
TTCAGAAAGGCACATGAGGACCACGGTTTGCCTCAGTTTCTGGTAAAACACAAGGTCTGGAGTGCCCCTGCAAAGGGTATTGATGGACTT
CCTGCCAGTGACAGAGCATGTCTATTGCAAACAATTCTCTCAGTTACGTTCAGCACTTAAGAACGGCTAATGGCAATAGGATCTTTAGCA
ACTTTTTCACATCATAGAAGGTGCAATCGCTCACTTGGGAACACTACTGAGAGTGACTTCTCTTTTAAAATTGAGTAGCAGATGAAAAAT
TAAAATTTGAACTTGATTATTAATATCAATTAAAATGTTTTATTTATTTTATTAAAAGCTCAATATTTTCTATGAATTCAAAAATACTTC
AGAGCCAAAGCCAACTTCAAATACCGTGACCAAATTTACATGATTCATATTCATTATGCATTACTTGGTATACAGACTTATTTTCATAAT
GCAAATTAATAAAATGACACTTTTACTGCACTATAGAAATATTCATGTATGTTAAACTTTTCTGATTGAGGCTAACTGGAAAAAGCTGGG
GTCGTATTCTAAGTGCTAAAGAAGGCTGCTTCTACTGTATAGAACCCAGGGCTCTGAAACAGCTCTAGCCGCCTAATGCACTTCACAGGT
AACTCCCCAAGGTAAAACTAGACTCTCTTGTTGGTTCGCAAAGAAAAGTTAGGACTTAACACTTTTTTCTAAAATTTTATAATTCAATTT
CCAAAAGTCTACTCTATTTTATACTGTTTCTACAAAATATTCCTTATAAAAACAAAGAACAAAAATTGAATATTTAATGAATTGACATTT
TATAACCAACCTGTTTTTATCTACGGTGGGAATCTTTGATGCCAGAAATTTATAAAGAGGTTCTGTATCTTCACACCTTGAATAAGCATA
ATACCATAAAAAATGACACTTGACATGTCAATGTATTTGTCATTTCATTTTAAACTCGTATTTGTGGTTTTTTTCCCAGATAAAAATGAA

>43257_43257_2_KMT2C-PDE8A_KMT2C_chr7_151900019_ENST00000355193_PDE8A_chr15_85607601_ENST00000310298_length(amino acids)=2135AA_BP=1366
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKK
RYRKRKNKLEETFPAYLQVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRN
PRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENS
EDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGG
KIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQ
ESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMEN
EEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPI
DEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHF
EHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVM

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Fusion Gene PPI Analysis for KMT2C-PDE8A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2C-PDE8A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2C-PDE8A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource