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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KMT2E-KANSL1 (FusionGDB2 ID:43283) |
Fusion Gene Summary for KMT2E-KANSL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KMT2E-KANSL1 | Fusion gene ID: 43283 | Hgene | Tgene | Gene symbol | KMT2E | KANSL1 | Gene ID | 55904 | 284058 |
| Gene name | lysine methyltransferase 2E (inactive) | KAT8 regulatory NSL complex subunit 1 | |
| Synonyms | HDCMC04P|MLL5|NKp44L|ODLURO | CENP-36|KDVS|KIAA1267|MSL1v1|NSL1|hMSL1v1 | |
| Cytomap | 7q22.3 | 17q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inactive histone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase MLL5inactive lysine N-methyltransferase 2Elysine (K)-specific methyltransferase 2Emyeloid/lymphoid or mixed-lineage leukemia 5 (trit | KAT8 regulatory NSL complex subunit 1MLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1centromere protein 36male-specific lethal 1 homolognon-specific lethal 1 homolog | |
| Modification date | 20200314 | 20200327 | |
| UniProtAcc | Q8IZD2 | A0AUZ9 | |
| Ensembl transtripts involved in fusion gene | ENST00000257745, ENST00000311117, ENST00000334877, ENST00000476671, ENST00000334914, ENST00000480368, | ENST00000262419, ENST00000393476, ENST00000432791, ENST00000572904, ENST00000574590, ENST00000575318, ENST00000576248, | |
| Fusion gene scores | * DoF score | 18 X 21 X 9=3402 | 17 X 18 X 11=3366 |
| # samples | 28 | 28 | |
| ** MAII score | log2(28/3402*10)=-3.60288440871842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/3366*10)=-3.58753644438498 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KMT2E [Title/Abstract] AND KANSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KMT2E(104681470)-KANSL1(44249598), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KANSL1 | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Tgene | KANSL1 | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Tgene | KANSL1 | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Fusion gene breakpoints across KMT2E (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across KANSL1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-8535-01A | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
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Fusion Gene ORF analysis for KMT2E-KANSL1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000257745 | ENST00000262419 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000257745 | ENST00000393476 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000257745 | ENST00000432791 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000257745 | ENST00000572904 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000257745 | ENST00000574590 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000311117 | ENST00000262419 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000311117 | ENST00000393476 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000311117 | ENST00000432791 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000311117 | ENST00000572904 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000311117 | ENST00000574590 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000334877 | ENST00000262419 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000334877 | ENST00000393476 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000334877 | ENST00000432791 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000334877 | ENST00000572904 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000334877 | ENST00000574590 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000476671 | ENST00000262419 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000476671 | ENST00000393476 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000476671 | ENST00000432791 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000476671 | ENST00000572904 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-5UTR | ENST00000476671 | ENST00000574590 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000257745 | ENST00000575318 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000257745 | ENST00000576248 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000311117 | ENST00000575318 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000311117 | ENST00000576248 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000334877 | ENST00000575318 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000334877 | ENST00000576248 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000476671 | ENST00000575318 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5CDS-intron | ENST00000476671 | ENST00000576248 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-5UTR | ENST00000334914 | ENST00000262419 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-5UTR | ENST00000334914 | ENST00000393476 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-5UTR | ENST00000334914 | ENST00000432791 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-5UTR | ENST00000334914 | ENST00000572904 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-5UTR | ENST00000334914 | ENST00000574590 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-intron | ENST00000334914 | ENST00000575318 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| 5UTR-intron | ENST00000334914 | ENST00000576248 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-5UTR | ENST00000480368 | ENST00000262419 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-5UTR | ENST00000480368 | ENST00000393476 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-5UTR | ENST00000480368 | ENST00000432791 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-5UTR | ENST00000480368 | ENST00000572904 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-5UTR | ENST00000480368 | ENST00000574590 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-intron | ENST00000480368 | ENST00000575318 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| intron-intron | ENST00000480368 | ENST00000576248 | KMT2E | chr7 | 104681470 | + | KANSL1 | chr17 | 44249598 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KMT2E-KANSL1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KMT2E-KANSL1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:104681470/:44249598) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KMT2E | KANSL1 |
| FUNCTION: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KMT2E-KANSL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for KMT2E-KANSL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KMT2E-KANSL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KMT2E-KANSL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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