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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KMT2E-SRSF7 (FusionGDB2 ID:43293)

Fusion Gene Summary for KMT2E-SRSF7

check button Fusion gene summary
Fusion gene informationFusion gene name: KMT2E-SRSF7
Fusion gene ID: 43293
HgeneTgene
Gene symbol

KMT2E

SRSF7

Gene ID

55904

6432

Gene namelysine methyltransferase 2E (inactive)serine and arginine rich splicing factor 7
SynonymsHDCMC04P|MLL5|NKp44L|ODLURO9G8|AAG3|SFRS7
Cytomap

7q22.3

2p22.1

Type of geneprotein-codingprotein-coding
Descriptioninactive histone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase 2Ehistone-lysine N-methyltransferase MLL5inactive lysine N-methyltransferase 2Elysine (K)-specific methyltransferase 2Emyeloid/lymphoid or mixed-lineage leukemia 5 (tritserine/arginine-rich splicing factor 7SR splicing factor 7aging-associated protein 3splicing factor 9G8splicing factor, arginine/serine-rich 7, 35kDa
Modification date2020031420200313
UniProtAcc

Q8IZD2

.
Ensembl transtripts involved in fusion geneENST00000334914, ENST00000257745, 
ENST00000311117, ENST00000334877, 
ENST00000476671, ENST00000480368, 
ENST00000313117, ENST00000409276, 
ENST00000446327, 
Fusion gene scores* DoF score18 X 21 X 9=340210 X 5 X 7=350
# samples 2810
** MAII scorelog2(28/3402*10)=-3.60288440871842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/350*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KMT2E [Title/Abstract] AND SRSF7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKMT2E(104704027)-SRSF7(38975795), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSRSF7

GO:0008380

RNA splicing

8013463

TgeneSRSF7

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664


check buttonFusion gene breakpoints across KMT2E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRSF7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315487KMT2Echr7

104704027

+SRSF7chr2

38975795

-


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Fusion Gene ORF analysis for KMT2E-SRSF7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000334914ENST00000313117KMT2Echr7

104704027

+SRSF7chr2

38975795

-
5UTR-3CDSENST00000334914ENST00000409276KMT2Echr7

104704027

+SRSF7chr2

38975795

-
5UTR-3CDSENST00000334914ENST00000446327KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000257745ENST00000313117KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000257745ENST00000409276KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000257745ENST00000446327KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000311117ENST00000313117KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000311117ENST00000409276KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000311117ENST00000446327KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000334877ENST00000313117KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000334877ENST00000409276KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000334877ENST00000446327KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000476671ENST00000313117KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000476671ENST00000409276KMT2Echr7

104704027

+SRSF7chr2

38975795

-
In-frameENST00000476671ENST00000446327KMT2Echr7

104704027

+SRSF7chr2

38975795

-
intron-3CDSENST00000480368ENST00000313117KMT2Echr7

104704027

+SRSF7chr2

38975795

-
intron-3CDSENST00000480368ENST00000409276KMT2Echr7

104704027

+SRSF7chr2

38975795

-
intron-3CDSENST00000480368ENST00000446327KMT2Echr7

104704027

+SRSF7chr2

38975795

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311117KMT2Echr7104704027+ENST00000313117SRSF7chr238975795-28269615451291248
ENST00000311117KMT2Echr7104704027+ENST00000446327SRSF7chr238975795-16399615451255236
ENST00000311117KMT2Echr7104704027+ENST00000409276SRSF7chr238975795-15239615451282245
ENST00000257745KMT2Echr7104704027+ENST00000313117SRSF7chr238975795-26678023861132248
ENST00000257745KMT2Echr7104704027+ENST00000446327SRSF7chr238975795-14808023861096236
ENST00000257745KMT2Echr7104704027+ENST00000409276SRSF7chr238975795-13648023861123245
ENST00000334877KMT2Echr7104704027+ENST00000313117SRSF7chr238975795-28159505341280248
ENST00000334877KMT2Echr7104704027+ENST00000446327SRSF7chr238975795-16289505341244236
ENST00000334877KMT2Echr7104704027+ENST00000409276SRSF7chr238975795-15129505341271245
ENST00000476671KMT2Echr7104704027+ENST00000313117SRSF7chr238975795-27879225061252248
ENST00000476671KMT2Echr7104704027+ENST00000446327SRSF7chr238975795-16009225061216236
ENST00000476671KMT2Echr7104704027+ENST00000409276SRSF7chr238975795-14849225061243245

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311117ENST00000313117KMT2Echr7104704027+SRSF7chr238975795-0.114109330.8858907
ENST00000311117ENST00000446327KMT2Echr7104704027+SRSF7chr238975795-0.0328267780.9671733
ENST00000311117ENST00000409276KMT2Echr7104704027+SRSF7chr238975795-0.0382813440.9617186
ENST00000257745ENST00000313117KMT2Echr7104704027+SRSF7chr238975795-0.133783240.8662168
ENST00000257745ENST00000446327KMT2Echr7104704027+SRSF7chr238975795-0.0396199520.9603801
ENST00000257745ENST00000409276KMT2Echr7104704027+SRSF7chr238975795-0.0452643970.95473564
ENST00000334877ENST00000313117KMT2Echr7104704027+SRSF7chr238975795-0.133099750.86690027
ENST00000334877ENST00000446327KMT2Echr7104704027+SRSF7chr238975795-0.0446935330.9553065
ENST00000334877ENST00000409276KMT2Echr7104704027+SRSF7chr238975795-0.0524768940.9475231
ENST00000476671ENST00000313117KMT2Echr7104704027+SRSF7chr238975795-0.109742060.89025795
ENST00000476671ENST00000446327KMT2Echr7104704027+SRSF7chr238975795-0.0383771550.96162283
ENST00000476671ENST00000409276KMT2Echr7104704027+SRSF7chr238975795-0.046904930.9530951

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Fusion Genomic Features for KMT2E-SRSF7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KMT2E-SRSF7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:104704027/chr2:38975795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2E

Q8IZD2

.
FUNCTION: Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (PubMed:23629655, PubMed:24130829, PubMed:23798402). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (PubMed:24130829, PubMed:23798402). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry (PubMed:14718661, PubMed:18573682, PubMed:19264965, PubMed:23629655). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity). {ECO:0000250|UniProtKB:Q3UG20, ECO:0000269|PubMed:14718661, ECO:0000269|PubMed:18573682, ECO:0000269|PubMed:23629655, ECO:0000269|PubMed:23798402, ECO:0000269|PubMed:24130829}.; FUNCTION: [Isoform NKp44L]: Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity. {ECO:0000269|PubMed:23958951}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728153_226128239.0RegionNote=6 X 8 AA repeats of R-R-S-R-S-X-S-X
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727153_226128227.0RegionNote=6 X 8 AA repeats of R-R-S-R-S-X-S-X
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728153_160128239.0RepeatNote=1
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728161_168128239.0RepeatNote=2
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728169_176128239.0RepeatNote=3
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728177_184128239.0RepeatNote=4
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728211_218128239.0RepeatNote=5%3B approximate
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728219_226128239.0RepeatNote=6%3B approximate
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727153_160128227.0RepeatNote=1
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727161_168128227.0RepeatNote=2
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727169_176128227.0RepeatNote=3
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727177_184128227.0RepeatNote=4
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727211_218128227.0RepeatNote=5%3B approximate
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727219_226128227.0RepeatNote=6%3B approximate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Echr7:104704027chr2:38975795ENST00000257745+426559_6151381859.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Echr7:104704027chr2:38975795ENST00000311117+527559_6151381859.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Echr7:104704027chr2:38975795ENST00000334877+526559_6151381817.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Echr7:104704027chr2:38975795ENST00000476671+515559_615138610.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Echr7:104704027chr2:38975795ENST00000257745+4261433_18461381859.0Compositional biasPro-rich
HgeneKMT2Echr7:104704027chr2:38975795ENST00000311117+5271433_18461381859.0Compositional biasPro-rich
HgeneKMT2Echr7:104704027chr2:38975795ENST00000334877+5261433_18461381817.0Compositional biasPro-rich
HgeneKMT2Echr7:104704027chr2:38975795ENST00000476671+5151433_1846138610.0Compositional biasPro-rich
HgeneKMT2Echr7:104704027chr2:38975795ENST00000257745+426330_4471381859.0DomainSET
HgeneKMT2Echr7:104704027chr2:38975795ENST00000311117+527330_4471381859.0DomainSET
HgeneKMT2Echr7:104704027chr2:38975795ENST00000334877+526330_4471381817.0DomainSET
HgeneKMT2Echr7:104704027chr2:38975795ENST00000476671+515330_447138610.0DomainSET
HgeneKMT2Echr7:104704027chr2:38975795ENST00000257745+426118_1661381859.0Zinc fingerPHD-type
HgeneKMT2Echr7:104704027chr2:38975795ENST00000311117+527118_1661381859.0Zinc fingerPHD-type
HgeneKMT2Echr7:104704027chr2:38975795ENST00000334877+526118_1661381817.0Zinc fingerPHD-type
HgeneKMT2Echr7:104704027chr2:38975795ENST00000476671+515118_166138610.0Zinc fingerPHD-type
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728121_238128239.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727121_238128227.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneSRSF7chr7:104704027chr2:38975795ENST000003131172811_84128239.0DomainRRM
TgeneSRSF7chr7:104704027chr2:38975795ENST000004463272711_84128227.0DomainRRM
TgeneSRSF7chr7:104704027chr2:38975795ENST0000031311728104_120128239.0Zinc fingerCCHC-type
TgeneSRSF7chr7:104704027chr2:38975795ENST0000044632727104_120128227.0Zinc fingerCCHC-type


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Fusion Gene Sequence for KMT2E-SRSF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43293_43293_1_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000257745_SRSF7_chr2_38975795_ENST00000313117_length(transcript)=2667nt_BP=802nt
CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAAC
AGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCC
TGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGT
TCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGT
AATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAG
GTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATC
ATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAG
TCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATG
GAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGT
CTAGATCACATTCTCGATCCAGAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGAC
GATCAAGATCTATCTCTCTTCGTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTATTTCCAAT
CCCCGTCGAGGTCAAGATCAAGATCCAGGTCTATTTCACGACCAAGAAGCAGCCGATCAAAGTCCAGATCTCCATCTCCAAAAAGAAGTC
GTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTG
TTTACATTATTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACT
ATGTAAATTCACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAATGTGGGTTTTTATTTGGCACATT
TAAATAAAATGTTTCTAACTAGATTTTTGATTTGTGTTCAATATTAACACTTCTTAATTTGATATATTTGAGAGTCAGACATTATAATTG
TTAACCTTATTCATACATACCTACATTCAGAATTGAAAGGTGTTGGTTAAGTCTTGAACATCACTATTCTATGCATAAAACTTGGCCAGG
ATCTTAAGGGACTTTGAAAATTCCATCTTACCCTTGTAGCTCTGGGTAAGATGACCTGAGTCCCTTATGATACAGCCTGAATGCATCATG
ACAGATCCTTAAGTTAGCTAATCCGTTTGAAGTTGGTGTTAGTAGGTATTGTATGATCAGTGGTGAAGCAAGTAGGACCACTGATGTGTC
TAAATGAGCATGACAGGAACTAAACGAAACTGATTAAATGTATGAGAAATAGAAACATTTCTGGATGATCTTTATACTAATTGCAGCTTT
CAGGCTACTAGGTGGCATAGTGTTAATTAGGACTCCCCAAGATATGGGGAGTTCTACTCTCAATGGTCTTGTTTCTTTGCTTTCTACATT
AGTTAACCAGTTTTATACCAAAAAATGCATGTTTGAGGAATTGTCTGAAATTGGGACAAAACACCTTCATGTAAACCAGCTTTGCAAAAT
TTTCCAGCCCAGATACTCTTCATCTATTCAAATGGATTGTCTTATTCTGAGCAAAGACCTGTTGTTAATCTTCAAGCTAGGTTTTGCAGT
TCCCAACCACAACATTCTTCTATTTTGCCAGGCTGGTGCAAAGTAATTAAAGATGTCAATCAGAAATGTCAATGAGACTAAAGTGGTTTT
GTAAATCTCAGCTATATTTAGCAACACTCCATGTAGCTAATATTTTTTGGTAGCATCTGGTAGACCTTAGAATGTTACATAGCCAGTAGG
TTCTTTATTCAAATTTTAAGTATCTTAAGAATAGTAGGGCAGTAACAGTTACTTTTGAGAGTTTTCTGGTCAAGCTTTTACCAGGCATTC
TCTAGCCTTGGTACAAAAAAAAAAAAACCTGCTGGTTGCGCAGATACCTAGGCTTGTCCATTTTATGCATTTCAGCAAAGTCATTGGATA
CTATTGCAACTTGGGAATACTGGTCTGCATCAAGTTTATTCGGTAGTTTGACCGCTAGTATGTTGGAAGTTATTTGGATTGTTTTTGGAA
TTTTGACTGGCTGAATTATGGTTGGTATAAAGTTATGTGTATAACTGGCAGGCTTATTTATCTGTTGCACTTGGTTAGCTTTAATTGTTC

>43293_43293_1_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000257745_SRSF7_chr2_38975795_ENST00000313117_length(amino acids)=248AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_2_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000257745_SRSF7_chr2_38975795_ENST00000409276_length(transcript)=1364nt_BP=802nt
CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAAC
AGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCC
TGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGT
TCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGT
AATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAG
GTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATC
ATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAG
TCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATG
GAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGT
CTAGATCACATTCTCGATCCAGAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGAC
GATCAAGATCTATCTCTCTTCGTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGATCCCCGTCGA
GGTCAAGATCAAGATCCAGGTCTATTTCACGACCAAGAAGCAGCCGATCAAAGTCCAGATCTCCATCTCCAAAAAGAAGTCGTTCCCCAT
CAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTA
TTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATT
CACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAATGTGGGTTTTTATTTGGCACATTTAAATAAAA

>43293_43293_2_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000257745_SRSF7_chr2_38975795_ENST00000409276_length(amino acids)=245AA_BP=170
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_3_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000257745_SRSF7_chr2_38975795_ENST00000446327_length(transcript)=1480nt_BP=802nt
CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAAC
AGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCC
TGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGT
TCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGT
AATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAG
GTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATC
ATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAG
TCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATG
GAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGT
CTAGATCACATTCTCGATCCAGAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGAC
GATCAAGATCTATCTCTCTTCGTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTATTTCCAAT
CCCCGTCGAGGTCAAGATCAAGATCCAGGTCTATTTCACGACCAAGAAGCAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTC
CTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTGTAAA
GTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAATTTTG
TTGAATGTATTAACATCATATGGTCTGAAAATGTGGGTTTTTATTTGGCACATTTAAATAAAATGTTTCTAACTAGATTTTTGATTTGTG
TTCAATATTAACACTTCTTAATTTGATATATTTGAGAGTCAGACATTATAATTGTTAACCTTATTCATACATACCTACATTCAGAATTGA

>43293_43293_3_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000257745_SRSF7_chr2_38975795_ENST00000446327_length(amino acids)=236AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_4_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000311117_SRSF7_chr2_38975795_ENST00000313117_length(transcript)=2826nt_BP=961nt
GCCGCCGCCGCCGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCG
GGAGCGGCAACAGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTAC
TCCTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGG
GGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTC
TATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAG
ATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGA
ACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAG
AAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTT
TGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAG
TAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAA
CCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCA
GAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTC
GTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTATTTCCAATCCCCGTCGAGGTCAAGATCAA
GATCCAGGTCTATTTCACGACCAAGAAGCAGCCGATCAAAGTCCAGATCTCCATCTCCAAAAAGAAGTCGTTCCCCATCAGGAAGTCCTC
GCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATT
TGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAG
ATAATATAAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAATGTGGGTTTTTATTTGGCACATTTAAATAAAATGTTTCTAACTA
GATTTTTGATTTGTGTTCAATATTAACACTTCTTAATTTGATATATTTGAGAGTCAGACATTATAATTGTTAACCTTATTCATACATACC
TACATTCAGAATTGAAAGGTGTTGGTTAAGTCTTGAACATCACTATTCTATGCATAAAACTTGGCCAGGATCTTAAGGGACTTTGAAAAT
TCCATCTTACCCTTGTAGCTCTGGGTAAGATGACCTGAGTCCCTTATGATACAGCCTGAATGCATCATGACAGATCCTTAAGTTAGCTAA
TCCGTTTGAAGTTGGTGTTAGTAGGTATTGTATGATCAGTGGTGAAGCAAGTAGGACCACTGATGTGTCTAAATGAGCATGACAGGAACT
AAACGAAACTGATTAAATGTATGAGAAATAGAAACATTTCTGGATGATCTTTATACTAATTGCAGCTTTCAGGCTACTAGGTGGCATAGT
GTTAATTAGGACTCCCCAAGATATGGGGAGTTCTACTCTCAATGGTCTTGTTTCTTTGCTTTCTACATTAGTTAACCAGTTTTATACCAA
AAAATGCATGTTTGAGGAATTGTCTGAAATTGGGACAAAACACCTTCATGTAAACCAGCTTTGCAAAATTTTCCAGCCCAGATACTCTTC
ATCTATTCAAATGGATTGTCTTATTCTGAGCAAAGACCTGTTGTTAATCTTCAAGCTAGGTTTTGCAGTTCCCAACCACAACATTCTTCT
ATTTTGCCAGGCTGGTGCAAAGTAATTAAAGATGTCAATCAGAAATGTCAATGAGACTAAAGTGGTTTTGTAAATCTCAGCTATATTTAG
CAACACTCCATGTAGCTAATATTTTTTGGTAGCATCTGGTAGACCTTAGAATGTTACATAGCCAGTAGGTTCTTTATTCAAATTTTAAGT
ATCTTAAGAATAGTAGGGCAGTAACAGTTACTTTTGAGAGTTTTCTGGTCAAGCTTTTACCAGGCATTCTCTAGCCTTGGTACAAAAAAA
AAAAAACCTGCTGGTTGCGCAGATACCTAGGCTTGTCCATTTTATGCATTTCAGCAAAGTCATTGGATACTATTGCAACTTGGGAATACT
GGTCTGCATCAAGTTTATTCGGTAGTTTGACCGCTAGTATGTTGGAAGTTATTTGGATTGTTTTTGGAATTTTGACTGGCTGAATTATGG
TTGGTATAAAGTTATGTGTATAACTGGCAGGCTTATTTATCTGTTGCACTTGGTTAGCTTTAATTGTTCTGTATTATTTAAAGATAAGTT

>43293_43293_4_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000311117_SRSF7_chr2_38975795_ENST00000313117_length(amino acids)=248AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_5_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000311117_SRSF7_chr2_38975795_ENST00000409276_length(transcript)=1523nt_BP=961nt
GCCGCCGCCGCCGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCG
GGAGCGGCAACAGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTAC
TCCTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGG
GGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTC
TATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAG
ATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGA
ACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAG
AAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTT
TGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAG
TAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAA
CCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCA
GAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTC
GTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGATCCCCGTCGAGGTCAAGATCAAGATCCAGGT
CTATTTCACGACCAAGAAGCAGCCGATCAAAGTCCAGATCTCCATCTCCAAAAAGAAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTG
CAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTC
TGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAA

>43293_43293_5_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000311117_SRSF7_chr2_38975795_ENST00000409276_length(amino acids)=245AA_BP=170
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_6_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000311117_SRSF7_chr2_38975795_ENST00000446327_length(transcript)=1639nt_BP=961nt
GCCGCCGCCGCCGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCG
GGAGCGGCAACAGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTAC
TCCTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGG
GGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTC
TATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAG
ATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGA
ACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAG
AAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTT
TGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAG
TAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAA
CCAGGTGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCA
GAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTC
GTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTATTTCCAATCCCCGTCGAGGTCAAGATCAA
GATCCAGGTCTATTTCACGACCAAGAAGCAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCT
CTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAAT
TCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATAT
GGTCTGAAAATGTGGGTTTTTATTTGGCACATTTAAATAAAATGTTTCTAACTAGATTTTTGATTTGTGTTCAATATTAACACTTCTTAA
TTTGATATATTTGAGAGTCAGACATTATAATTGTTAACCTTATTCATACATACCTACATTCAGAATTGAAAGGTGTTGGTTAAGTCTTGA

>43293_43293_6_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000311117_SRSF7_chr2_38975795_ENST00000446327_length(amino acids)=236AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_7_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000334877_SRSF7_chr2_38975795_ENST00000313117_length(transcript)=2815nt_BP=950nt
CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAAC
AGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCC
TGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGT
TCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATA
AGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAAT
GAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGC
ATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCT
GTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCG
GACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTT
ACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATA
TGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGA
TACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTCGTAGATCAAGA
TCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTATTTCCAATCCCCGTCGAGGTCAAGATCAAGATCCAGGTCT
ATTTCACGACCAAGAAGCAGCCGATCAAAGTCCAGATCTCCATCTCCAAAAAGAAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCA
AGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTG
TAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAAT
TTTGTTGAATGTATTAACATCATATGGTCTGAAAATGTGGGTTTTTATTTGGCACATTTAAATAAAATGTTTCTAACTAGATTTTTGATT
TGTGTTCAATATTAACACTTCTTAATTTGATATATTTGAGAGTCAGACATTATAATTGTTAACCTTATTCATACATACCTACATTCAGAA
TTGAAAGGTGTTGGTTAAGTCTTGAACATCACTATTCTATGCATAAAACTTGGCCAGGATCTTAAGGGACTTTGAAAATTCCATCTTACC
CTTGTAGCTCTGGGTAAGATGACCTGAGTCCCTTATGATACAGCCTGAATGCATCATGACAGATCCTTAAGTTAGCTAATCCGTTTGAAG
TTGGTGTTAGTAGGTATTGTATGATCAGTGGTGAAGCAAGTAGGACCACTGATGTGTCTAAATGAGCATGACAGGAACTAAACGAAACTG
ATTAAATGTATGAGAAATAGAAACATTTCTGGATGATCTTTATACTAATTGCAGCTTTCAGGCTACTAGGTGGCATAGTGTTAATTAGGA
CTCCCCAAGATATGGGGAGTTCTACTCTCAATGGTCTTGTTTCTTTGCTTTCTACATTAGTTAACCAGTTTTATACCAAAAAATGCATGT
TTGAGGAATTGTCTGAAATTGGGACAAAACACCTTCATGTAAACCAGCTTTGCAAAATTTTCCAGCCCAGATACTCTTCATCTATTCAAA
TGGATTGTCTTATTCTGAGCAAAGACCTGTTGTTAATCTTCAAGCTAGGTTTTGCAGTTCCCAACCACAACATTCTTCTATTTTGCCAGG
CTGGTGCAAAGTAATTAAAGATGTCAATCAGAAATGTCAATGAGACTAAAGTGGTTTTGTAAATCTCAGCTATATTTAGCAACACTCCAT
GTAGCTAATATTTTTTGGTAGCATCTGGTAGACCTTAGAATGTTACATAGCCAGTAGGTTCTTTATTCAAATTTTAAGTATCTTAAGAAT
AGTAGGGCAGTAACAGTTACTTTTGAGAGTTTTCTGGTCAAGCTTTTACCAGGCATTCTCTAGCCTTGGTACAAAAAAAAAAAAACCTGC
TGGTTGCGCAGATACCTAGGCTTGTCCATTTTATGCATTTCAGCAAAGTCATTGGATACTATTGCAACTTGGGAATACTGGTCTGCATCA
AGTTTATTCGGTAGTTTGACCGCTAGTATGTTGGAAGTTATTTGGATTGTTTTTGGAATTTTGACTGGCTGAATTATGGTTGGTATAAAG
TTATGTGTATAACTGGCAGGCTTATTTATCTGTTGCACTTGGTTAGCTTTAATTGTTCTGTATTATTTAAAGATAAGTTTACTCAACAAT

>43293_43293_7_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000334877_SRSF7_chr2_38975795_ENST00000313117_length(amino acids)=248AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_8_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000334877_SRSF7_chr2_38975795_ENST00000409276_length(transcript)=1512nt_BP=950nt
CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAAC
AGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCC
TGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGT
TCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATA
AGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAAT
GAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGC
ATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCT
GTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCG
GACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTT
ACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATA
TGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGA
TACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTCGTAGATCAAGA
TCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGATCCCCGTCGAGGTCAAGATCAAGATCCAGGTCTATTTCACGA
CCAAGAAGCAGCCGATCAAAGTCCAGATCTCCATCTCCAAAAAGAAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAA
AGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTGTAAAGTGTA
ACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAATTTTGTTGAA

>43293_43293_8_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000334877_SRSF7_chr2_38975795_ENST00000409276_length(amino acids)=245AA_BP=170
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_9_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000334877_SRSF7_chr2_38975795_ENST00000446327_length(transcript)=1628nt_BP=950nt
CGCCGCCATTTTCCCAGAGCGAGAGGCAGTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAAC
AGAGTGGGCATAGACACTCCGAGCAGCCTCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCC
TGGTGAAGAGGCTGCGCGCTGCTGTTTGGGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGT
TCGCGGAGGTGCGGAGAGACTCCTTGGGGGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATA
AGCAGGTTTTGTGAAGACATTTATTCTTTCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAAT
GAGCACTGTGGCTGGCATGCCCCAGTGTTTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGC
ATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCT
GTGGTAGTTGAGAAATCCAACAGTTATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCG
GACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTT
ACCACTCCTAATTTTGATGAAACTTCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATA
TGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGA
TACTCTCGCTCACGCAGCAGGAGCAGGGGACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTCGTAGATCAAGA
TCAGCTTCACTCAGAAGATCTAGGTCTGGTTCTATAAAAGGATCGAGGTATTTCCAATCCCCGTCGAGGTCAAGATCAAGATCCAGGTCT
ATTTCACGACCAAGAAGCAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCAC
CCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTA
ATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAAT
GTGGGTTTTTATTTGGCACATTTAAATAAAATGTTTCTAACTAGATTTTTGATTTGTGTTCAATATTAACACTTCTTAATTTGATATATT
TGAGAGTCAGACATTATAATTGTTAACCTTATTCATACATACCTACATTCAGAATTGAAAGGTGTTGGTTAAGTCTTGAACATCACTATT

>43293_43293_9_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000334877_SRSF7_chr2_38975795_ENST00000446327_length(amino acids)=236AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_10_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000476671_SRSF7_chr2_38975795_ENST00000313117_length(transcript)=2787nt_BP=922nt
GTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAACAGAGTGGGCATAGACACTCCGAGCAGCC
TCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTG
GGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGG
GGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTT
TCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGT
TTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAG
CAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATC
CCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTC
CGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCA
GTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACA
TGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGG
GACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTCGTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTG
GTTCTATAAAAGGATCGAGGTATTTCCAATCCCCGTCGAGGTCAAGATCAAGATCCAGGTCTATTTCACGACCAAGAAGCAGCCGATCAA
AGTCCAGATCTCCATCTCCAAAAAGAAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTC
AAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCA
ACCATCTAATCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATATGGT
CTGAAAATGTGGGTTTTTATTTGGCACATTTAAATAAAATGTTTCTAACTAGATTTTTGATTTGTGTTCAATATTAACACTTCTTAATTT
GATATATTTGAGAGTCAGACATTATAATTGTTAACCTTATTCATACATACCTACATTCAGAATTGAAAGGTGTTGGTTAAGTCTTGAACA
TCACTATTCTATGCATAAAACTTGGCCAGGATCTTAAGGGACTTTGAAAATTCCATCTTACCCTTGTAGCTCTGGGTAAGATGACCTGAG
TCCCTTATGATACAGCCTGAATGCATCATGACAGATCCTTAAGTTAGCTAATCCGTTTGAAGTTGGTGTTAGTAGGTATTGTATGATCAG
TGGTGAAGCAAGTAGGACCACTGATGTGTCTAAATGAGCATGACAGGAACTAAACGAAACTGATTAAATGTATGAGAAATAGAAACATTT
CTGGATGATCTTTATACTAATTGCAGCTTTCAGGCTACTAGGTGGCATAGTGTTAATTAGGACTCCCCAAGATATGGGGAGTTCTACTCT
CAATGGTCTTGTTTCTTTGCTTTCTACATTAGTTAACCAGTTTTATACCAAAAAATGCATGTTTGAGGAATTGTCTGAAATTGGGACAAA
ACACCTTCATGTAAACCAGCTTTGCAAAATTTTCCAGCCCAGATACTCTTCATCTATTCAAATGGATTGTCTTATTCTGAGCAAAGACCT
GTTGTTAATCTTCAAGCTAGGTTTTGCAGTTCCCAACCACAACATTCTTCTATTTTGCCAGGCTGGTGCAAAGTAATTAAAGATGTCAAT
CAGAAATGTCAATGAGACTAAAGTGGTTTTGTAAATCTCAGCTATATTTAGCAACACTCCATGTAGCTAATATTTTTTGGTAGCATCTGG
TAGACCTTAGAATGTTACATAGCCAGTAGGTTCTTTATTCAAATTTTAAGTATCTTAAGAATAGTAGGGCAGTAACAGTTACTTTTGAGA
GTTTTCTGGTCAAGCTTTTACCAGGCATTCTCTAGCCTTGGTACAAAAAAAAAAAAACCTGCTGGTTGCGCAGATACCTAGGCTTGTCCA
TTTTATGCATTTCAGCAAAGTCATTGGATACTATTGCAACTTGGGAATACTGGTCTGCATCAAGTTTATTCGGTAGTTTGACCGCTAGTA
TGTTGGAAGTTATTTGGATTGTTTTTGGAATTTTGACTGGCTGAATTATGGTTGGTATAAAGTTATGTGTATAACTGGCAGGCTTATTTA

>43293_43293_10_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000476671_SRSF7_chr2_38975795_ENST00000313117_length(amino acids)=248AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_11_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000476671_SRSF7_chr2_38975795_ENST00000409276_length(transcript)=1484nt_BP=922nt
GTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAACAGAGTGGGCATAGACACTCCGAGCAGCC
TCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTG
GGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGG
GGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTT
TCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGT
TTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAG
CAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATC
CCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTC
CGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCA
GTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACA
TGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGG
GACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTCGTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTG
GTTCTATAAAAGGATCGAGATCCCCGTCGAGGTCAAGATCAAGATCCAGGTCTATTTCACGACCAAGAAGCAGCCGATCAAAGTCCAGAT
CTCCATCTCCAAAAAGAAGTCGTTCCCCATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACC
CTTTAGGGAAAAGTTATTTTGTTTACATTATTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAA
TCAAAATGGATCTGGATTACTATGTAAATTCACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAATG

>43293_43293_11_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000476671_SRSF7_chr2_38975795_ENST00000409276_length(amino acids)=245AA_BP=170
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------
>43293_43293_12_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000476671_SRSF7_chr2_38975795_ENST00000446327_length(transcript)=1600nt_BP=922nt
GTGACACTGAGCGGGCGCAGGGGGCCGAGTCGGAGACCGTGCCGGAGTTCGGGAGCGGCAACAGAGTGGGCATAGACACTCCGAGCAGCC
TCGCCGTCGTCTCTGCGTTCCTGTTGACTGCCTGGCTGCCCCCTCCCCTACTCCTCGGTTCCTGGTGAAGAGGCTGCGCGCTGCTGTTTG
GGGAGGGGGTGTGTGGAGCCGGGTCCTGTGTCCGCAGTGGCTGCTGTCGGGGGGTCGCCTGTTCGCGGAGGTGCGGAGAGACTCCTTGGG
GGTCGAGCACATAACGGGGTTCGGGTGTCTCGTGTGTGAACATCACAGGTCTATTCTGGATAAGCAGGTTTTGTGAAGACATTTATTCTT
TCTTGGACCTCAGATTTACCAGACATCTCATGGGTTTGTGGATGCACTTAGATGTTTGCAATGAGCACTGTGGCTGGCATGCCCCAGTGT
TTTGGATACCAATGCATAGGACTCCATAGTAATCGAATTTACCAGAGGCGAACGTCATGAGCATAGTGATCCCATTGGGGGTTGATACAG
CAGAGACGTCATACTTGGAAATGGCTGCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGTTATC
CCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCCTATGCGGACCATAATTATGGTGCTCGTCCTCCTC
CGACACCTCCGGCTTCCCCTCCTCCATCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACTTCCA
GTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGGTGCATATGTGGTTTTACACATGATGATGGATACA
TGATCTGTTGTGACAAATGCAGGTCACGGTCTAGATCACATTCTCGATCCAGAGGAAGGCGATACTCTCGCTCACGCAGCAGGAGCAGGG
GACGAAGGTCAAGGTCAGCATCTCCTCGACGATCAAGATCTATCTCTCTTCGTAGATCAAGATCAGCTTCACTCAGAAGATCTAGGTCTG
GTTCTATAAAAGGATCGAGGTATTTCCAATCCCCGTCGAGGTCAAGATCAAGATCCAGGTCTATTTCACGACCAAGAAGCAGTCGTTCCC
CATCAGGAAGTCCTCGCAGAAGTGCAAGTCCTGAAAGAATGGACTGAAGCTCTCAAGTTCACCCTTTAGGGAAAAGTTATTTTGTTTACA
TTATTATAAGGGATTTGTGATGTCTGTAAAGTGTAACCTAGGAAAGATAATTCAACCATCTAATCAAAATGGATCTGGATTACTATGTAA
ATTCACAGCAGTAAGATAATATAAATTTTGTTGAATGTATTAACATCATATGGTCTGAAAATGTGGGTTTTTATTTGGCACATTTAAATA
AAATGTTTCTAACTAGATTTTTGATTTGTGTTCAATATTAACACTTCTTAATTTGATATATTTGAGAGTCAGACATTATAATTGTTAACC

>43293_43293_12_KMT2E-SRSF7_KMT2E_chr7_104704027_ENST00000476671_SRSF7_chr2_38975795_ENST00000446327_length(amino acids)=236AA_BP=136
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVG
IFTTPNFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KMT2E-SRSF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KMT2E-SRSF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KMT2E-SRSF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource