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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KNDC1-CRIP1 (FusionGDB2 ID:43321)

Fusion Gene Summary for KNDC1-CRIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: KNDC1-CRIP1
Fusion gene ID: 43321
HgeneTgene
Gene symbol

KNDC1

CRIP1

Gene ID

85442

25927

Gene namekinase non-catalytic C-lobe domain containing 1cannabinoid receptor interacting protein 1
SynonymsC10orf23|RASGEF2|Very-KIND|bB439H18.3|v-KINDC2orf32|CRIP-1|CRIP1
Cytomap

10q26.3

2p14

Type of geneprotein-codingprotein-coding
Descriptionkinase non-catalytic C-lobe domain-containing protein 1KIND domain-containing protein 1RasGEF domain family, member 2cerebral protein 9kinase non-catalytic C-lobe domain (KIND) containing 1protein very KINDras-GEF domain-containing family member 2CB1 cannabinoid receptor-interacting protein 1cannabinoid receptor CB1-interacting protein 1
Modification date2020031320200313
UniProtAcc

Q76NI1

P50238

Ensembl transtripts involved in fusion geneENST00000304613, ENST00000368571, 
ENST00000368572, ENST00000530127, 
ENST00000330233, ENST00000392531, 
ENST00000409393, ENST00000551180, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: KNDC1 [Title/Abstract] AND CRIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKNDC1(134996878)-CRIP1(105954667), # samples:6
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KNDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A004-01AKNDC1chr10

134996878

+CRIP1chr14

105954667

+
ChimerDB4COADTCGA-AZ-4681-01AKNDC1chr10

134996878

+CRIP1chr14

105954667

+
ChimerDB4UCECTCGA-AX-A06J-01AKNDC1chr10

134996878

+CRIP1chr14

105954667

+
ChimerDB4UCECTCGA-B5-A0KB-01BKNDC1chr10

134996878

+CRIP1chr14

105954667

+
ChimerDB4UCECTCGA-D1-A16E-01AKNDC1chr10

134996878

+CRIP1chr14

105954667

+
ChimerDB4UCECTCGA-D1-A177-01AKNDC1chr10

134996878

+CRIP1chr14

105954667

+


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Fusion Gene ORF analysis for KNDC1-CRIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000304613ENST00000330233KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000304613ENST00000392531KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000304613ENST00000409393KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000304613ENST00000551180KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368571ENST00000330233KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368571ENST00000392531KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368571ENST00000409393KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368571ENST00000551180KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368572ENST00000330233KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368572ENST00000392531KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368572ENST00000409393KNDC1chr10

134996878

+CRIP1chr14

105954667

+
In-frameENST00000368572ENST00000551180KNDC1chr10

134996878

+CRIP1chr14

105954667

+
intron-3CDSENST00000530127ENST00000330233KNDC1chr10

134996878

+CRIP1chr14

105954667

+
intron-3CDSENST00000530127ENST00000392531KNDC1chr10

134996878

+CRIP1chr14

105954667

+
intron-3CDSENST00000530127ENST00000409393KNDC1chr10

134996878

+CRIP1chr14

105954667

+
intron-3CDSENST00000530127ENST00000551180KNDC1chr10

134996878

+CRIP1chr14

105954667

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304613KNDC1chr10134996878+ENST00000330233CRIP1chr14105954667+7304975360179
ENST00000304613KNDC1chr10134996878+ENST00000409393CRIP1chr14105954667+8864975360179
ENST00000304613KNDC1chr10134996878+ENST00000392531CRIP1chr14105954667+7304975360179
ENST00000304613KNDC1chr10134996878+ENST00000551180CRIP1chr14105954667+143749777883231
ENST00000368572KNDC1chr10134996878+ENST00000330233CRIP1chr14105954667+7104775161172
ENST00000368572KNDC1chr10134996878+ENST00000409393CRIP1chr14105954667+8664775161172
ENST00000368572KNDC1chr10134996878+ENST00000392531CRIP1chr14105954667+7104775161172
ENST00000368572KNDC1chr10134996878+ENST00000551180CRIP1chr14105954667+141747775863231
ENST00000368571KNDC1chr10134996878+ENST00000330233CRIP1chr14105954667+80457161062182
ENST00000368571KNDC1chr10134996878+ENST00000409393CRIP1chr14105954667+96057161062182
ENST00000368571KNDC1chr10134996878+ENST00000392531CRIP1chr14105954667+80457161062182
ENST00000368571KNDC1chr10134996878+ENST00000551180CRIP1chr14105954667+1511571852172226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304613ENST00000330233KNDC1chr10134996878+CRIP1chr14105954667+0.0211773780.97882265
ENST00000304613ENST00000409393KNDC1chr10134996878+CRIP1chr14105954667+0.019531270.98046875
ENST00000304613ENST00000392531KNDC1chr10134996878+CRIP1chr14105954667+0.0211773780.97882265
ENST00000304613ENST00000551180KNDC1chr10134996878+CRIP1chr14105954667+0.0465529040.9534471
ENST00000368572ENST00000330233KNDC1chr10134996878+CRIP1chr14105954667+0.0238660180.97613394
ENST00000368572ENST00000409393KNDC1chr10134996878+CRIP1chr14105954667+0.0234954580.97650456
ENST00000368572ENST00000392531KNDC1chr10134996878+CRIP1chr14105954667+0.0238660180.97613394
ENST00000368572ENST00000551180KNDC1chr10134996878+CRIP1chr14105954667+0.0420202840.95797974
ENST00000368571ENST00000330233KNDC1chr10134996878+CRIP1chr14105954667+0.57760290.4223971
ENST00000368571ENST00000409393KNDC1chr10134996878+CRIP1chr14105954667+0.63276180.36723816
ENST00000368571ENST00000392531KNDC1chr10134996878+CRIP1chr14105954667+0.57760290.4223971
ENST00000368571ENST00000551180KNDC1chr10134996878+CRIP1chr14105954667+0.83214750.16785255

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Fusion Genomic Features for KNDC1-CRIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KNDC1-CRIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:134996878/chr14:105954667)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KNDC1

Q76NI1

CRIP1

P50238

FUNCTION: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}.FUNCTION: Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCRIP1chr10:134996878chr14:105954667ENST000003302331562_7045-206.66666666666666Compositional biasNote=Gly-rich
TgeneCRIP1chr10:134996878chr14:105954667ENST000003925312662_7045102.33333333333333Compositional biasNote=Gly-rich
TgeneCRIP1chr10:134996878chr14:105954667ENST000004093932662_7045137.66666666666666Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKNDC1chr10:134996878chr14:105954667ENST00000304613+1301133_119001750.0Coiled coilOntology_term=ECO:0000255
HgeneKNDC1chr10:134996878chr14:105954667ENST00000368571+1181133_119001142.0Coiled coilOntology_term=ECO:0000255
HgeneKNDC1chr10:134996878chr14:105954667ENST00000304613+130724_88501750.0Compositional biasNote=Pro-rich
HgeneKNDC1chr10:134996878chr14:105954667ENST00000368571+118724_88501142.0Compositional biasNote=Pro-rich
HgeneKNDC1chr10:134996878chr14:105954667ENST00000304613+1301246_137101750.0DomainN-terminal Ras-GEF
HgeneKNDC1chr10:134996878chr14:105954667ENST00000304613+1301468_171901750.0DomainRas-GEF
HgeneKNDC1chr10:134996878chr14:105954667ENST00000304613+13037_21701750.0DomainKIND 1
HgeneKNDC1chr10:134996878chr14:105954667ENST00000304613+130444_60801750.0DomainKIND 2
HgeneKNDC1chr10:134996878chr14:105954667ENST00000368571+1181246_137101142.0DomainN-terminal Ras-GEF
HgeneKNDC1chr10:134996878chr14:105954667ENST00000368571+1181468_171901142.0DomainRas-GEF
HgeneKNDC1chr10:134996878chr14:105954667ENST00000368571+11837_21701142.0DomainKIND 1
HgeneKNDC1chr10:134996878chr14:105954667ENST00000368571+118444_60801142.0DomainKIND 2
TgeneCRIP1chr10:134996878chr14:105954667ENST00000330233152_6345-206.66666666666666DomainLIM zinc-binding
TgeneCRIP1chr10:134996878chr14:105954667ENST00000392531262_6345102.33333333333333DomainLIM zinc-binding
TgeneCRIP1chr10:134996878chr14:105954667ENST00000409393262_6345137.66666666666666DomainLIM zinc-binding


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Fusion Gene Sequence for KNDC1-CRIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43321_43321_1_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000330233_length(transcript)=730nt_BP=497nt
GGTGCGCGGCGCGGCCGCAGGATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGAC
TTCGAGCCGCTGCCCACCCTCCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAG
GAAGCCTGGGCCGTGTGCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGAC
ACCCTGGCCTTCAACACCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGAC
GTGACCGGGAACACCTTTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGC
TGAGCCGGATGCAGGCGGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCA
TGTTTGGGCCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTG
CAGGGCCACTGTCCAGGCAAATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC

>43321_43321_1_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000330233_length(amino acids)=179AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV

--------------------------------------------------------------
>43321_43321_2_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000392531_length(transcript)=730nt_BP=497nt
GGTGCGCGGCGCGGCCGCAGGATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGAC
TTCGAGCCGCTGCCCACCCTCCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAG
GAAGCCTGGGCCGTGTGCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGAC
ACCCTGGCCTTCAACACCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGAC
GTGACCGGGAACACCTTTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGC
TGAGCCGGATGCAGGCGGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCA
TGTTTGGGCCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTG
CAGGGCCACTGTCCAGGCAAATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC

>43321_43321_2_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000392531_length(amino acids)=179AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV

--------------------------------------------------------------
>43321_43321_3_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000409393_length(transcript)=886nt_BP=497nt
GGTGCGCGGCGCGGCCGCAGGATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGAC
TTCGAGCCGCTGCCCACCCTCCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAG
GAAGCCTGGGCCGTGTGCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGAC
ACCCTGGCCTTCAACACCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGAC
GTGACCGGGAACACCTTTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGC
TGAGCCGGATGCAGGCGGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCA
TGTTTGGGCCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTG
CAGGGCCACTGTCCAGGCAAATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC
TTGGAAAACCTGTGTGTGTACATGCGCGTGTGTGCTGGGGAGTGCCAAGGGAGCTGCAGTGGGGTCCTGGCAGCAGGCTCTGCCACCGGC

>43321_43321_3_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000409393_length(amino acids)=179AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV

--------------------------------------------------------------
>43321_43321_4_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000551180_length(transcript)=1437nt_BP=497nt
GGTGCGCGGCGCGGCCGCAGGATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGAC
TTCGAGCCGCTGCCCACCCTCCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAG
GAAGCCTGGGCCGTGTGCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGAC
ACCCTGGCCTTCAACACCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGAC
GTGACCGGGAACACCTTTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGC
TGAGCCGGATGCAGGCGGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCA
TGTTTGGGCCTAAAGGCTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTG
CAGGGCCACTGTCCAGGCAAATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACAC
TTGGAAAACCTGTGTGTGTACATGCGCGTGTGTGCTGGGGAGTGCCAAGGGAGCTGCAGTGGGGTCCTGGCAGCAGGCTCTGCCACCGGC
GCCTGCTCTTCTGCTGCCCATTGCCCTCCCCAGGGGGCCGTTCCAGGGTCTCATAGGCGAGGGCTCCCTGTGCAGGGCCAGGCCCAGCTT
CTGCAAGGGCCTGATGAGGCTGCTCTGCCCCTGACCCAGGCACCACTGCCCCATGTGCGTCCTCATCTGCCATCTACCCTGTGCCCAGGG
ACTTACCCAGTGGCCCGGCGTCCAGTGGGGAACTTGAGTACCGGCCGTGCACAGGGGCTGGGGGGCCTTCTGGAAACTCCCTTGTCAACT
CAGCCAGCCGCTGCTGACTGGCCACCTTCAGAGACCCTCTTCCCCACACTGGCTACTTAGATACCGGCCTTGGCAGAAGGCCACCCCTCC
GGACACCCACTGGTTTAAAAGAGCCCAGGGGTCTGGCCCTGCCTTAGGGCTGTGGTGGGTGTGCTGCAGGCTCAGCTCGACAGCCCTGCC
AGGAGCCCGGAAGTGGGTCCGCACGAGACAGAATAGACTACACTCAAACTCCAGGGGAACCGTTCATTGGGCTTGGACACGAAGGCGGGA

>43321_43321_4_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000304613_CRIP1_chr14_105954667_ENST00000551180_length(amino acids)=231AA_BP=1
MQLPWHSPAHTRMYTHRFSKCSGLLRALGATREPWASGDKAWHLPGQWPCKQPRMGSPPPGLLESVALGSAPPKAFRPKHGCVAGVVAVG
FAFVLKVRPVPGVLRLHPAQQRLEVLAQPGFQCGLCHVLEGGLSKVFPVTSNSGGTKAPSGSSLSCSMKHTFPLVLKARVSGVMHRLWKM

--------------------------------------------------------------
>43321_43321_5_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000330233_length(transcript)=804nt_BP=571nt
GTTCCGTGGCTCTGACGTCCAGGGAACAGCAGGACGACTCTTGAAACAAAATGAGACGTGGTCTAAAGCCCTTTCCCTGACCCACGCGTT
GAAACGCTGCCACGAGTCGTCCGTTTCCCCAGGGAATCGTCTCGGTGGGGGTGCCGGGGCCTGGCTGGGGGTCCTGCCGGGCTCACGGCC
AGGGCCGGTCTTGGCAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGT
GCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACA
CCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCT
TTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGC
GGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGG
CTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAG

>43321_43321_5_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000330233_length(amino acids)=182AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV
GRDAQALEDGGVGHAPHGQAALQAHGPGFLLAEAAVPQGEDVSQRHVLLPRPALAVSPAGPPARPRHPHRDDSLGKRTTRGSVSTRGSGK

--------------------------------------------------------------
>43321_43321_6_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000392531_length(transcript)=804nt_BP=571nt
GTTCCGTGGCTCTGACGTCCAGGGAACAGCAGGACGACTCTTGAAACAAAATGAGACGTGGTCTAAAGCCCTTTCCCTGACCCACGCGTT
GAAACGCTGCCACGAGTCGTCCGTTTCCCCAGGGAATCGTCTCGGTGGGGGTGCCGGGGCCTGGCTGGGGGTCCTGCCGGGCTCACGGCC
AGGGCCGGTCTTGGCAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGT
GCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACA
CCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCT
TTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGC
GGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGG
CTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAG

>43321_43321_6_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000392531_length(amino acids)=182AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV
GRDAQALEDGGVGHAPHGQAALQAHGPGFLLAEAAVPQGEDVSQRHVLLPRPALAVSPAGPPARPRHPHRDDSLGKRTTRGSVSTRGSGK

--------------------------------------------------------------
>43321_43321_7_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000409393_length(transcript)=960nt_BP=571nt
GTTCCGTGGCTCTGACGTCCAGGGAACAGCAGGACGACTCTTGAAACAAAATGAGACGTGGTCTAAAGCCCTTTCCCTGACCCACGCGTT
GAAACGCTGCCACGAGTCGTCCGTTTCCCCAGGGAATCGTCTCGGTGGGGGTGCCGGGGCCTGGCTGGGGGTCCTGCCGGGCTCACGGCC
AGGGCCGGTCTTGGCAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGT
GCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACA
CCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCT
TTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGC
GGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGG
CTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAG
GCAAATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACACTTGGAAAACCTGTGTG
TGTACATGCGCGTGTGTGCTGGGGAGTGCCAAGGGAGCTGCAGTGGGGTCCTGGCAGCAGGCTCTGCCACCGGCGCCTGCTCTTCTGCTG

>43321_43321_7_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000409393_length(amino acids)=182AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV
GRDAQALEDGGVGHAPHGQAALQAHGPGFLLAEAAVPQGEDVSQRHVLLPRPALAVSPAGPPARPRHPHRDDSLGKRTTRGSVSTRGSGK

--------------------------------------------------------------
>43321_43321_8_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000551180_length(transcript)=1511nt_BP=571nt
GTTCCGTGGCTCTGACGTCCAGGGAACAGCAGGACGACTCTTGAAACAAAATGAGACGTGGTCTAAAGCCCTTTCCCTGACCCACGCGTT
GAAACGCTGCCACGAGTCGTCCGTTTCCCCAGGGAATCGTCTCGGTGGGGGTGCCGGGGCCTGGCTGGGGGTCCTGCCGGGCTCACGGCC
AGGGCCGGTCTTGGCAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGT
GCCTGGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACA
CCAGCGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCT
TTGAGAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGC
GGAGGACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGG
CTTTGGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAG
GCAAATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACACTTGGAAAACCTGTGTG
TGTACATGCGCGTGTGTGCTGGGGAGTGCCAAGGGAGCTGCAGTGGGGTCCTGGCAGCAGGCTCTGCCACCGGCGCCTGCTCTTCTGCTG
CCCATTGCCCTCCCCAGGGGGCCGTTCCAGGGTCTCATAGGCGAGGGCTCCCTGTGCAGGGCCAGGCCCAGCTTCTGCAAGGGCCTGATG
AGGCTGCTCTGCCCCTGACCCAGGCACCACTGCCCCATGTGCGTCCTCATCTGCCATCTACCCTGTGCCCAGGGACTTACCCAGTGGCCC
GGCGTCCAGTGGGGAACTTGAGTACCGGCCGTGCACAGGGGCTGGGGGGCCTTCTGGAAACTCCCTTGTCAACTCAGCCAGCCGCTGCTG
ACTGGCCACCTTCAGAGACCCTCTTCCCCACACTGGCTACTTAGATACCGGCCTTGGCAGAAGGCCACCCCTCCGGACACCCACTGGTTT
AAAAGAGCCCAGGGGTCTGGCCCTGCCTTAGGGCTGTGGTGGGTGTGCTGCAGGCTCAGCTCGACAGCCCTGCCAGGAGCCCGGAAGTGG
GTCCGCACGAGACAGAATAGACTACACTCAAACTCCAGGGGAACCGTTCATTGGGCTTGGACACGAAGGCGGGACCCTGCCGACGCAGTG

>43321_43321_8_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368571_CRIP1_chr14_105954667_ENST00000551180_length(amino acids)=226AA_BP=1
MQLPWHSPAHTRMYTHRFSKCSGLLRALGATREPWASGDKAWHLPGQWPCKQPRMGSPPPGLLESVALGSAPPKAFRPKHGCVAGVVAVG
FAFVLKVRPVPGVLRLHPAQQRLEVLAQPGFQCGLCHVLEGGLSKVFPVTSNSGGTKAPSGSSLSCSMKHTFPLVLKARVSGVMHRLWKM

--------------------------------------------------------------
>43321_43321_9_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000330233_length(transcript)=710nt_BP=477nt
GATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGACTTCGAGCCGCTGCCCACCCT
CCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGTGCCT
GGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACACCAG
CGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCTTTGA
GAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGCGGAG
GACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGGCTTT
GGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAA

>43321_43321_9_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000330233_length(amino acids)=172AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV

--------------------------------------------------------------
>43321_43321_10_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000392531_length(transcript)=710nt_BP=477nt
GATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGACTTCGAGCCGCTGCCCACCCT
CCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGTGCCT
GGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACACCAG
CGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCTTTGA
GAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGCGGAG
GACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGGCTTT
GGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAA

>43321_43321_10_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000392531_length(amino acids)=172AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV

--------------------------------------------------------------
>43321_43321_11_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000409393_length(transcript)=866nt_BP=477nt
GATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGACTTCGAGCCGCTGCCCACCCT
CCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGTGCCT
GGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACACCAG
CGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCTTTGA
GAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGCGGAG
GACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGGCTTT
GGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAA
ATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACACTTGGAAAACCTGTGTGTGTA
CATGCGCGTGTGTGCTGGGGAGTGCCAAGGGAGCTGCAGTGGGGTCCTGGCAGCAGGCTCTGCCACCGGCGCCTGCTCTTCTGCTGCCCA

>43321_43321_11_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000409393_length(amino acids)=172AA_BP=1
MRSRGGCSRVCLRAQGPAGPRGPPPASGSAAPRGLGSAWVPVWALPRTRGRPLKGVPGHVELGGNEGTLRVVAELLHETHVPAGVEGQGV

--------------------------------------------------------------
>43321_43321_12_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000551180_length(transcript)=1417nt_BP=477nt
GATGCAGGCCATGGACCCGGCCGCGGCGGATCTTTACGAGGAGGACGGCAAAGACCTGGACTTCTACGACTTCGAGCCGCTGCCCACCCT
CCCCGAGGACGAGGAGAACGTGTCTCTGGCTGACATCCTCTCCCTGCGGGACCGCGGCCTCAGCGAGCAGGAAGCCTGGGCCGTGTGCCT
GGAGTGCAGCCTGTCCATGCGGAGCGTGGCCCACGCCGCCATCTTCCAGAGCCTGTGCATCACGCCCGACACCCTGGCCTTCAACACCAG
CGGGAACGTGTGTTTCATGGAGCAGCTCAGCGACGACCCTGAGGGTGCCTTCGTTCCCCCCGAGTTCGACGTGACCGGGAACACCTTTGA
GAGGCCGCCCTCGAGTACGTGGCAGAGCCCACACTGGAACCCAGGCTGAGCCAAGACCTCGAGGCGCTGCTGAGCCGGATGCAGGCGGAG
GACCCCGGGGACCGGCCGGACCTTGAGCACGAAGGCAAACCCTACTGCAACCACCCCTGCTACGCAGCCATGTTTGGGCCTAAAGGCTTT
GGGCGGGGCGGAGCCGAGAGCCACACTTTCAAGTAAACCAGGTGGTGGAGACCCCATCCTTGGCTGCTTGCAGGGCCACTGTCCAGGCAA
ATGCCAGGCCTTGTCCCCAGATGCCCAGGGCTCCCTTGTTGCCCCTAATGCTCTCAGTAAACCTGAACACTTGGAAAACCTGTGTGTGTA
CATGCGCGTGTGTGCTGGGGAGTGCCAAGGGAGCTGCAGTGGGGTCCTGGCAGCAGGCTCTGCCACCGGCGCCTGCTCTTCTGCTGCCCA
TTGCCCTCCCCAGGGGGCCGTTCCAGGGTCTCATAGGCGAGGGCTCCCTGTGCAGGGCCAGGCCCAGCTTCTGCAAGGGCCTGATGAGGC
TGCTCTGCCCCTGACCCAGGCACCACTGCCCCATGTGCGTCCTCATCTGCCATCTACCCTGTGCCCAGGGACTTACCCAGTGGCCCGGCG
TCCAGTGGGGAACTTGAGTACCGGCCGTGCACAGGGGCTGGGGGGCCTTCTGGAAACTCCCTTGTCAACTCAGCCAGCCGCTGCTGACTG
GCCACCTTCAGAGACCCTCTTCCCCACACTGGCTACTTAGATACCGGCCTTGGCAGAAGGCCACCCCTCCGGACACCCACTGGTTTAAAA
GAGCCCAGGGGTCTGGCCCTGCCTTAGGGCTGTGGTGGGTGTGCTGCAGGCTCAGCTCGACAGCCCTGCCAGGAGCCCGGAAGTGGGTCC
GCACGAGACAGAATAGACTACACTCAAACTCCAGGGGAACCGTTCATTGGGCTTGGACACGAAGGCGGGACCCTGCCGACGCAGTGATTG

>43321_43321_12_KNDC1-CRIP1_KNDC1_chr10_134996878_ENST00000368572_CRIP1_chr14_105954667_ENST00000551180_length(amino acids)=231AA_BP=1
MQLPWHSPAHTRMYTHRFSKCSGLLRALGATREPWASGDKAWHLPGQWPCKQPRMGSPPPGLLESVALGSAPPKAFRPKHGCVAGVVAVG
FAFVLKVRPVPGVLRLHPAQQRLEVLAQPGFQCGLCHVLEGGLSKVFPVTSNSGGTKAPSGSSLSCSMKHTFPLVLKARVSGVMHRLWKM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KNDC1-CRIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KNDC1-CRIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KNDC1-CRIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource