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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KNG1-FETUB (FusionGDB2 ID:43326)

Fusion Gene Summary for KNG1-FETUB

check button Fusion gene summary
Fusion gene informationFusion gene name: KNG1-FETUB
Fusion gene ID: 43326
HgeneTgene
Gene symbol

KNG1

FETUB

Gene ID

3827

26998

Gene namekininogen 1fetuin B
SynonymsBDK|BK|HMWK|KNG16G2|Gugu|IRL685
Cytomap

3q27.3

3q27.3

Type of geneprotein-codingprotein-coding
Descriptionkininogen-1alpha-2-thiol proteinase inhibitorbradykininfitzgerald factorhigh molecular weight kininogenwilliams-Fitzgerald-Flaujeac factorfetuin-Bfetuin-like protein IRL685
Modification date2020031520200313
UniProtAcc

P01042

.
Ensembl transtripts involved in fusion geneENST00000265023, ENST00000287611, 
ENST00000447445, 		ENST00000382136, 
ENST00000488561, ENST00000265029, 
ENST00000382134, ENST00000450521, 
ENST00000539949, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 2 X 2=8
# samples 42
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: KNG1 [Title/Abstract] AND FETUB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKNG1(186435526)-FETUB(186364037), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKNG1

GO:0007162

negative regulation of cell adhesion

11970955

HgeneKNG1

GO:0007204

positive regulation of cytosolic calcium ion concentration

16014619

HgeneKNG1

GO:0030195

negative regulation of blood coagulation

11970955

HgeneKNG1

GO:0045861

negative regulation of proteolysis

3488317


check buttonFusion gene breakpoints across KNG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FETUB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A3A5-01AKNG1chr3

186435526

+FETUBchr3

186364037

+


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Fusion Gene ORF analysis for KNG1-FETUB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265023ENST00000382136KNG1chr3

186435526

+FETUBchr3

186364037

+
5CDS-intronENST00000265023ENST00000488561KNG1chr3

186435526

+FETUBchr3

186364037

+
5CDS-intronENST00000287611ENST00000382136KNG1chr3

186435526

+FETUBchr3

186364037

+
5CDS-intronENST00000287611ENST00000488561KNG1chr3

186435526

+FETUBchr3

186364037

+
5CDS-intronENST00000447445ENST00000382136KNG1chr3

186435526

+FETUBchr3

186364037

+
5CDS-intronENST00000447445ENST00000488561KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000265023ENST00000265029KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000265023ENST00000382134KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000265023ENST00000450521KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000265023ENST00000539949KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000287611ENST00000265029KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000287611ENST00000382134KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000287611ENST00000450521KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000287611ENST00000539949KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000447445ENST00000265029KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000447445ENST00000382134KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000447445ENST00000450521KNG1chr3

186435526

+FETUBchr3

186364037

+
In-frameENST00000447445ENST00000539949KNG1chr3

186435526

+FETUBchr3

186364037

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KNG1-FETUB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KNG1chr3186435526+FETUBchr3186364036+11.03E-08
KNG1chr3186435526+FETUBchr3186364036+11.03E-08

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KNG1-FETUB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:186435526/chr3:186364037)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KNG1

P01042

.
FUNCTION: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110420_51065645.0Compositional biasNote=His-rich
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111420_51065428.0Compositional biasNote=His-rich
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110420_51065392.0Compositional biasNote=His-rich
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110151_25465645.0DomainCystatin kininogen-type 2
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110273_37665645.0DomainCystatin kininogen-type 3
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+11028_13265645.0DomainCystatin kininogen-type 1
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111151_25465428.0DomainCystatin kininogen-type 2
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111273_37665428.0DomainCystatin kininogen-type 3
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+11128_13265428.0DomainCystatin kininogen-type 1
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110151_25465392.0DomainCystatin kininogen-type 2
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110273_37665392.0DomainCystatin kininogen-type 3
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+11028_13265392.0DomainCystatin kininogen-type 1
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110120_15365645.0RegionNote=O-glycosylated at one site only
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111120_15365428.0RegionNote=O-glycosylated at one site only
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110120_15365392.0RegionNote=O-glycosylated at one site only
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110420_44965645.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110450_47965645.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000265023+110480_51065645.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111420_44965428.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111450_47965428.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000287611+111480_51065428.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110420_44965392.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110450_47965392.0Repeat.
HgeneKNG1chr3:186435526chr3:186364037ENST00000447445+110480_51065392.0Repeat.
TgeneFETUBchr3:186435526chr3:186364037ENST0000026502937149_255198383.0DomainCystatin fetuin-B-type 2
TgeneFETUBchr3:186435526chr3:186364037ENST000002650293725_138198383.0DomainCystatin fetuin-B-type 1
TgeneFETUBchr3:186435526chr3:186364037ENST0000038213626149_255161346.0DomainCystatin fetuin-B-type 2
TgeneFETUBchr3:186435526chr3:186364037ENST000003821362625_138161346.0DomainCystatin fetuin-B-type 1
TgeneFETUBchr3:186435526chr3:186364037ENST0000045052148149_255198383.0DomainCystatin fetuin-B-type 2
TgeneFETUBchr3:186435526chr3:186364037ENST000004505214825_138198383.0DomainCystatin fetuin-B-type 1


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Fusion Gene Sequence for KNG1-FETUB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KNG1-FETUB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KNG1-FETUB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KNG1-FETUB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource