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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KNG1-HRG (FusionGDB2 ID:43327) |
Fusion Gene Summary for KNG1-HRG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KNG1-HRG | Fusion gene ID: 43327 | Hgene | Tgene | Gene symbol | KNG1 | HRG | Gene ID | 3827 | 3273 |
| Gene name | kininogen 1 | histidine rich glycoprotein | |
| Synonyms | BDK|BK|HMWK|KNG | HPRG|HRGP|THPH11 | |
| Cytomap | 3q27.3 | 3q27.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | kininogen-1alpha-2-thiol proteinase inhibitorbradykininfitzgerald factorhigh molecular weight kininogenwilliams-Fitzgerald-Flaujeac factor | histidine-rich glycoproteinhistidine-proline-rich glycoprotein | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | P01042 | P04196 | |
| Ensembl transtripts involved in fusion gene | ENST00000265023, ENST00000287611, ENST00000447445, | ENST00000232003, ENST00000468154, | |
| Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: KNG1 [Title/Abstract] AND HRG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KNG1(186461328)-HRG(186395361), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KNG1 | GO:0007162 | negative regulation of cell adhesion | 11970955 |
| Hgene | KNG1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 16014619 |
| Hgene | KNG1 | GO:0030195 | negative regulation of blood coagulation | 11970955 |
| Hgene | KNG1 | GO:0045861 | negative regulation of proteolysis | 3488317 |
| Tgene | HRG | GO:0002839 | positive regulation of immune response to tumor cell | 21215706 |
| Tgene | HRG | GO:0007162 | negative regulation of cell adhesion | 14744774 |
| Tgene | HRG | GO:0008285 | negative regulation of cell proliferation | 14744774 |
| Tgene | HRG | GO:0010468 | regulation of gene expression | 21215706 |
| Tgene | HRG | GO:0010593 | negative regulation of lamellipodium assembly | 16489009 |
| Tgene | HRG | GO:0016525 | negative regulation of angiogenesis | 14744774|16436387|16489009|19903770 |
| Tgene | HRG | GO:0030168 | platelet activation | 19903770 |
| Tgene | HRG | GO:0030193 | regulation of blood coagulation | 6740558|21304106 |
| Tgene | HRG | GO:0030308 | negative regulation of cell growth | 21215706 |
| Tgene | HRG | GO:0032956 | regulation of actin cytoskeleton organization | 16489009 |
| Tgene | HRG | GO:0033629 | negative regulation of cell adhesion mediated by integrin | 16489009 |
| Tgene | HRG | GO:0043065 | positive regulation of apoptotic process | 14744774 |
| Tgene | HRG | GO:0043254 | regulation of protein complex assembly | 16489009 |
| Tgene | HRG | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 16489009 |
| Tgene | HRG | GO:0050832 | defense response to fungus | 18797515 |
| Tgene | HRG | GO:0051838 | cytolysis by host of symbiont cells | 18797515 |
| Tgene | HRG | GO:0051894 | positive regulation of focal adhesion assembly | 14744774|16436387 |
| Tgene | HRG | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 18797515 |
| Tgene | HRG | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | 16489009 |
| Tgene | HRG | GO:2000504 | positive regulation of blood vessel remodeling | 21215706 |
| Tgene | HRG | GO:2001027 | negative regulation of endothelial cell chemotaxis | 14744774|16436387|16489009 |
| Fusion gene breakpoints across KNG1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across HRG (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-ZS-A9CF-01A | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| ChimerDB4 | LIHC | TCGA-ZS-A9CF-02A | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
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Fusion Gene ORF analysis for KNG1-HRG |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000265023 | ENST00000232003 | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| 3UTR-intron | ENST00000265023 | ENST00000468154 | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| intron-3CDS | ENST00000287611 | ENST00000232003 | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| intron-3CDS | ENST00000447445 | ENST00000232003 | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| intron-intron | ENST00000287611 | ENST00000468154 | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| intron-intron | ENST00000447445 | ENST00000468154 | KNG1 | chr3 | 186461328 | + | HRG | chr3 | 186395361 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for KNG1-HRG |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KNG1-HRG |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:186461328/:186395361) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KNG1 | HRG |
| FUNCTION: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. | FUNCTION: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. {ECO:0000269|PubMed:11134179, ECO:0000269|PubMed:12235005, ECO:0000269|PubMed:14744774, ECO:0000269|PubMed:15220341, ECO:0000269|PubMed:15313924, ECO:0000269|PubMed:16436387, ECO:0000269|PubMed:16489009, ECO:0000269|PubMed:19285951, ECO:0000269|PubMed:19535045, ECO:0000269|PubMed:19712047, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:20573803, ECO:0000269|PubMed:21215706, ECO:0000269|PubMed:21304106}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KNG1-HRG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for KNG1-HRG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KNG1-HRG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KNG1-HRG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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