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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KPNA1-GMPS (FusionGDB2 ID:43360)

Fusion Gene Summary for KPNA1-GMPS

check button Fusion gene summary
Fusion gene informationFusion gene name: KPNA1-GMPS
Fusion gene ID: 43360
HgeneTgene
Gene symbol

KPNA1

GMPS

Gene ID

3836

8833

Gene namekaryopherin subunit alpha 1guanine monophosphate synthase
SynonymsIPOA5|NPI-1|RCH2|SRP1GATD7
Cytomap

3q21.1

3q25.31

Type of geneprotein-codingprotein-coding
Descriptionimportin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2GMP synthase [glutamine-hydrolyzing]GMP synthaseGMP synthetaseMLL/GMPS fusion proteinglutamine amidotransferaseguanine monophosphate synthetaseguanosine 5'-monophosphate synthasetesticular tissue protein Li 82
Modification date2020031320200313
UniProtAcc

P52294

P49915

Ensembl transtripts involved in fusion geneENST00000344337, ENST00000466923, 
ENST00000476145, ENST00000295920, 
ENST00000496455, 
Fusion gene scores* DoF score19 X 10 X 13=24708 X 7 X 6=336
# samples 2611
** MAII scorelog2(26/2470*10)=-3.24792751344359
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/336*10)=-1.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KPNA1 [Title/Abstract] AND GMPS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKPNA1(122215284)-GMPS(155637022), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGMPS

GO:0006177

GMP biosynthetic process

8089153


check buttonFusion gene breakpoints across KPNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GMPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7147-01AKPNA1chr3

122215283

-GMPSchr3

155637021

+
ChimerDB4LUADTCGA-78-7147-01AKPNA1chr3

122215284

-GMPSchr3

155637022

+
ChimerDB4LUADTCGA-78-7147KPNA1chr3

122215283

-GMPSchr3

155637021

+


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Fusion Gene ORF analysis for KPNA1-GMPS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344337ENST00000476145KPNA1chr3

122215284

-GMPSchr3

155637022

+
5CDS-intronENST00000344337ENST00000476145KPNA1chr3

122215283

-GMPSchr3

155637021

+
In-frameENST00000344337ENST00000295920KPNA1chr3

122215284

-GMPSchr3

155637022

+
In-frameENST00000344337ENST00000295920KPNA1chr3

122215283

-GMPSchr3

155637021

+
In-frameENST00000344337ENST00000496455KPNA1chr3

122215284

-GMPSchr3

155637022

+
In-frameENST00000344337ENST00000496455KPNA1chr3

122215283

-GMPSchr3

155637021

+
intron-3CDSENST00000466923ENST00000295920KPNA1chr3

122215284

-GMPSchr3

155637022

+
intron-3CDSENST00000466923ENST00000295920KPNA1chr3

122215283

-GMPSchr3

155637021

+
intron-3CDSENST00000466923ENST00000496455KPNA1chr3

122215284

-GMPSchr3

155637022

+
intron-3CDSENST00000466923ENST00000496455KPNA1chr3

122215283

-GMPSchr3

155637021

+
intron-intronENST00000466923ENST00000476145KPNA1chr3

122215284

-GMPSchr3

155637022

+
intron-intronENST00000466923ENST00000476145KPNA1chr3

122215283

-GMPSchr3

155637021

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344337KPNA1chr3122215284-ENST00000496455GMPSchr3155637022+7510306511175374
ENST00000344337KPNA1chr3122215284-ENST00000295920GMPSchr3155637022+1194306511175374
ENST00000344337KPNA1chr3122215283-ENST00000496455GMPSchr3155637021+7510306511175374
ENST00000344337KPNA1chr3122215283-ENST00000295920GMPSchr3155637021+1194306511175374

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344337ENST00000496455KPNA1chr3122215284-GMPSchr3155637022+0.0012906140.99870944
ENST00000344337ENST00000295920KPNA1chr3122215284-GMPSchr3155637022+0.0039523540.9960477
ENST00000344337ENST00000496455KPNA1chr3122215283-GMPSchr3155637021+0.0012906140.99870944
ENST00000344337ENST00000295920KPNA1chr3122215283-GMPSchr3155637021+0.0039523540.9960477

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Fusion Genomic Features for KPNA1-GMPS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KPNA1chr3122215283-GMPSchr3155637021+1.84E-060.9999982
KPNA1chr3122215283-GMPSchr3155637021+1.84E-060.9999982
KPNA1chr3122215283-GMPSchr3155637021+1.84E-060.9999982
KPNA1chr3122215283-GMPSchr3155637021+1.84E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KPNA1-GMPS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:122215284/chr3:155637022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KPNA1

P52294

GMPS

P49915

FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.FUNCTION: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-21425_2843539.0Compositional biasNote=Poly-Arg
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-21425_2843539.0Compositional biasNote=Poly-Arg

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-2141_5743539.0DomainIBB
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-2141_5743539.0DomainIBB
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-21442_5143539.0MotifNuclear localization signal
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-21442_5143539.0MotifNuclear localization signal
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214149_24143539.0RegionNLS binding site (major)
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214245_43743539.0RegionNote=Binding to RAG1
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214318_40643539.0RegionNLS binding site (minor)
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214149_24143539.0RegionNLS binding site (major)
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214245_43743539.0RegionNote=Binding to RAG1
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214318_40643539.0RegionNLS binding site (minor)
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214118_16143539.0RepeatNote=ARM 2
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214162_20643539.0RepeatNote=ARM 3
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214207_24543539.0RepeatNote=ARM 4
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214246_29043539.0RepeatNote=ARM 5
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214291_33043539.0RepeatNote=ARM 6
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214331_37243539.0RepeatNote=ARM 7
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214373_41243539.0RepeatNote=ARM 8
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214413_45743539.0RepeatNote=ARM 9
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-214460_50443539.0RepeatNote=ARM 10%3B atypical
HgeneKPNA1chr3:122215283chr3:155637021ENST00000344337-21477_11743539.0RepeatNote=ARM 1%3B truncated
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214118_16143539.0RepeatNote=ARM 2
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214162_20643539.0RepeatNote=ARM 3
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214207_24543539.0RepeatNote=ARM 4
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214246_29043539.0RepeatNote=ARM 5
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214291_33043539.0RepeatNote=ARM 6
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214331_37243539.0RepeatNote=ARM 7
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214373_41243539.0RepeatNote=ARM 8
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214413_45743539.0RepeatNote=ARM 9
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-214460_50443539.0RepeatNote=ARM 10%3B atypical
HgeneKPNA1chr3:122215284chr3:155637022ENST00000344337-21477_11743539.0RepeatNote=ARM 1%3B truncated
TgeneGMPSchr3:122215283chr3:155637021ENST00000496455816217_435404694.0DomainGMPS ATP-PPase
TgeneGMPSchr3:122215283chr3:155637021ENST0000049645581627_216404694.0DomainGlutamine amidotransferase type-1
TgeneGMPSchr3:122215284chr3:155637022ENST00000496455816217_435404694.0DomainGMPS ATP-PPase
TgeneGMPSchr3:122215284chr3:155637022ENST0000049645581627_216404694.0DomainGlutamine amidotransferase type-1
TgeneGMPSchr3:122215283chr3:155637021ENST00000496455816244_250404694.0Nucleotide bindingATP
TgeneGMPSchr3:122215284chr3:155637022ENST00000496455816244_250404694.0Nucleotide bindingATP


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Fusion Gene Sequence for KPNA1-GMPS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43360_43360_1_KPNA1-GMPS_KPNA1_chr3_122215283_ENST00000344337_GMPS_chr3_155637021_ENST00000295920_length(transcript)=1194nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTG
GGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAA
CCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTA
TTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTG
CCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCA
CTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCT
ACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCT
GGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAG
AGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTA
TTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGG

>43360_43360_1_KPNA1-GMPS_KPNA1_chr3_122215283_ENST00000344337_GMPS_chr3_155637021_ENST00000295920_length(amino acids)=374AA_BP=85
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQGKVIE
PLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM
QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLR
QADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM

--------------------------------------------------------------
>43360_43360_2_KPNA1-GMPS_KPNA1_chr3_122215283_ENST00000344337_GMPS_chr3_155637021_ENST00000496455_length(transcript)=7510nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTG
GGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAA
CCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTA
TTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTG
CCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCA
CTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCT
ACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCT
GGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAG
AGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTA
TTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGG
GAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAATCATTCCCATTATTGACATGCAGTACTGTGAAA
AGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTTAAGAGCTGAGTTGGGGATAACCAAAAGGGACT
GAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGATACTGCTTTTGCCTTTGCCTCACTTATTCTTTA
TGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGGGTAATTATGGGCTTCTGTCTCCTTACCAGTTT
CTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACTTTTTGGAGAATCAGTTTTCTTATAAGTAATCT
TATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTATTCCAGCCACTTTTGAAGGACACTGAGGGTAT
AAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAATTTTATTTCACAGCCTTGGGAGGAAGAAACTA
TGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACATAGATGCCATGTTATTCAATGTCAGCTTGTTTA
TTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTG
GCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGAT
CACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATATCATCTAGTAAACAGTTGTAAAATGAGCTTTTA
AATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACATGCAAGATGTTTGCCAAACTTTGTAATCCTTT
CTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCACCAGTTTCTAACAGATCTTTTATAACATTCACATA
AGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGAATGTTACCATATTTTTCTCTTAACAATTCCAT
CTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAATTTTATTTGGGATTCAGTGTTAGACAAACAAC
AAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTG
TCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTTAAAGGGTACATTCTCTATCTGATGAGGAGGTA
CTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGAGTCATGTTATTTGAAAGCTAGAATAGACAACC
TATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTTCTAGCCACAGTGTCTTATGATTTTGTATTGAA
GCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACACTGCTCCACTGAGAAGGTCCATGTAAAAAGGATT
AGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCATGGTATATAATATTCAAAGCTCTGAGAAATTCTG
AAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTTTTTGAACACCTTTTATATAATCCCTTCTAATATA
TACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGACATGACATAGTTTCTTAAAAATCCAAATTTTC
TGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTTGCTTTGTGCCATATAGCATTACTCTGTACCTT
CACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGTTAAGAAAACAAGCTCACCTTAGGCATGGTTAC
TTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTATTCTGACACCTAAAATTATATAAACATTTATG
GGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATTGGTTATTCTGGGCATATCATGACTTTATTCCC
GTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTTGTACTTTTTAGGTAGACAGAGAATGTAGATCA
TTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAATACCCAGTCCTGCCTTAAAGGCCACATCTATG
ATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGATATATCCAGGAGATAGGGTTACACTGTTTTCT
AACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCATCATAAAATTTGTTTCCTCACTGTTTGGGCTT
AACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAGAGCATTCAAATTAGGAAGGCAGGACTATCCATCT
TTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTTCTTTATCTGTGACATGAGGTAACTGTATTAAATT
TTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGGAGACAGAATGGAGAAGCTGGATAGTGTTTTTT
TTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAATGCACCGTAAAGTTAAATCCTAGTTACCTTTTT
TTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTTGAAAAACACCCATCAAAGTTTTCCTGGTAGGA
ATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGACACTAATGAAGTCACCCATCATCAATTACATA
CAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGAAGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATC
TTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGATCAGGA
GATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACAAATTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATAGTGCCACTGCACTCCGGC
CTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTGTGTAATTGACCATCAGGGATAAATGGGCTTCAAA
AGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAAATTCTCTGACATCTGCTTGCGCAATGTTATAA
CCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCCTTAGCTATCACCCCAATGGATGCTTCTTTCAT
TGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTGGAAAGCACATCTTTTGTTCTTACTGAAGTAGT
TTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACTGAAGGACTTTGACAGCAGTAATGGTGGCATTG
TTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCCCCAAAGAGTGTCAAGATGCTAACTTCCAACCC
TATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCAGTGTTCCTCAACACTGGATGCGTATTATTACATA
ACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAAATTAGAATCTGGAGGAGGTAGAACTCAAGCATTTACAGTTTTG
TTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCTTCGTGGGTTCA
CGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTTTTTTGTACTTTTTAGTAGAG
ACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCCGCCTCGGCCTCTCAGAGTGCTGGGATTACAGG
CGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAAATTCTTATTGAGGGCCATACCTAGCCTGTCTTCA
TCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGATGGTCTTGCTGAAGGTCTTATAGCTAAATTAG
TTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAGACACTCCCAGGACCTGTTTGGTAATAATTAGG
ACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTCTTTCAACCTCTTTCTTCTTACTTCTTTACTTT
TCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCTAGCTAGGTCATGAAACAGACTGAGCTATTATT
GCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACCTAGCTGCAACCTAAGTTTCCTGAATTAGAATC
ATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTGGCGCATGCCTGTAATCCCAGCACTTTGGGAGGCC
GAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTGAAACCCCATTTCTACTAAAAATGTAAAAATTAGC
TGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGAATCACTTAAACCCGGGAGATGGAGGTTGCAGTGA
GCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTAAAACAAAAACAACATATTTGTTCACTTTTGAACC
CTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAGGAAATTTGGCTATTGAGTATATTAAGTACAAC
TACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGTGGAGTATATATCTTCAAGAATACAGATTTTTA
AGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATTAAACGAAGAAGTGAATGTAAACCTCCTTTTGA
ACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAATCACTGTGTAATTGTTAATTGTAAACTGCAATG
TCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACTTTAATCCCTTTTGTCTTCAATATACTTCATAA
AGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTCCAAGAAGTAAGAGCCAAGAGGACAGATATTAT
CAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTAATTTATTTCCCTTGCATATATAGTAGGGGTTA
ACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTTATTTAAATGAGCTAAAGGTGTGCGTATACACA

>43360_43360_2_KPNA1-GMPS_KPNA1_chr3_122215283_ENST00000344337_GMPS_chr3_155637021_ENST00000496455_length(amino acids)=374AA_BP=85
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQGKVIE
PLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM
QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLR
QADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM

--------------------------------------------------------------
>43360_43360_3_KPNA1-GMPS_KPNA1_chr3_122215284_ENST00000344337_GMPS_chr3_155637022_ENST00000295920_length(transcript)=1194nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTG
GGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAA
CCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTA
TTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTG
CCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCA
CTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCT
ACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCT
GGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAG
AGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTA
TTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGG

>43360_43360_3_KPNA1-GMPS_KPNA1_chr3_122215284_ENST00000344337_GMPS_chr3_155637022_ENST00000295920_length(amino acids)=374AA_BP=85
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQGKVIE
PLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM
QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLR
QADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM

--------------------------------------------------------------
>43360_43360_4_KPNA1-GMPS_KPNA1_chr3_122215284_ENST00000344337_GMPS_chr3_155637022_ENST00000496455_length(transcript)=7510nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGGGAAAAGTAATAGAACCTCTGAAAGATTTTCATAAAGATGAAGTGAGAATTTTG
GGCAGAGAACTTGGACTTCCAGAAGAGTTAGTTTCCAGGCATCCATTTCCAGGTCCTGGCCTGGCAATCAGAGTAATATGTGCTGAAGAA
CCTTATATTTGTAAGGACTTTCCTGAAACCAACAATATTTTGAAAATAGTAGCTGATTTTTCTGCAAGTGTTAAAAAGCCACATACCCTA
TTACAGAGAGTCAAAGCCTGCACAACAGAAGAGGATCAGGAGAAGCTGATGCAAATTACCAGTCTGCATTCACTGAATGCCTTCTTGCTG
CCAATTAAAACTGTAGGTGTGCAGGGTGACTGTCGTTCCTACAGTTACGTGTGTGGAATCTCCAGTAAAGATGAACCTGACTGGGAATCA
CTTATTTTTCTGGCTAGGCTTATACCTCGCATGTGTCACAACGTTAACAGAGTTGTTTATATATTTGGCCCACCAGTTAAAGAACCTCCT
ACAGATGTTACTCCCACTTTCTTGACAACAGGGGTGCTCAGTACTTTACGCCAAGCTGATTTTGAGGCCCATAACATTCTCAGGGAGTCT
GGGTATGCTGGGAAAATCAGCCAGATGCCGGTGATTTTGACACCATTACATTTTGATCGGGACCCACTTCAAAAGCAGCCTTCATGCCAG
AGATCTGTGGTTATTCGAACCTTTATTACTAGTGACTTCATGACTGGTATACCTGCAACACCTGGCAATGAGATCCCTGTAGAGGTGGTA
TTAAAGATGGTCACTGAGATTAAGAAGATTCCTGGTATTTCTCGAATTATGTATGACTTAACATCAAAGCCCCCAGGAACTACTGAGTGG
GAGTAATAAACTTCTTGTTCTATTAAAGTACCGTGTGCAGTTTAAATTGATTAGAAATCATTCCCATTATTGACATGCAGTACTGTGAAA
AGAGTTACTGGAGCAGCTACATCACATCTGAGTTCTCCACAGCAAAAATCTACGGCTTAAGAGCTGAGTTGGGGATAACCAAAAGGGACT
GAAGAGTTTGTACGGGTAAATAATCAAAGCACCATTGCCTACACTCAGACAGATTGATACTGCTTTTGCCTTTGCCTCACTTATTCTTTA
TGTATAAATTCACTGTTGATGTCTCTGTGAATATGTATGAAGGTGGGTGAATTTGGGGGTAATTATGGGCTTCTGTCTCCTTACCAGTTT
CTAAGAACTGTTAGAAACGCCCATTATTTACCAGTGTTACTTACTACTTATATATACTTTTTGGAGAATCAGTTTTCTTATAAGTAATCT
TATTTCTCCAAAGGGTGAAAAAGAGATGAACATATCAGATAAAGGTATAGGTGGGCTATTCCAGCCACTTTTGAAGGACACTGAGGGTAT
AAAATGTAAGCTACCATAAGATGGAAAAGCACCAGGAATTTGTTGATGTACTTTTGAATTTTATTTCACAGCCTTGGGAGGAAGAAACTA
TGAGTGGTCTCAGATGTCTATGAATGGTCTTAAAATGTTTTCAAACCATGTTCCACATAGATGCCATGTTATTCAATGTCAGCTTGTTTA
TTAGTAAGGAGCTTTATCCTCCTAGCCTTATATTACCAGCCCCCCACAGCCTTGCATAGAAAGTTTCTGTTATCTCCTTAGAAGAAACTG
GCTCAATGACGTTTCTGGTGTAGTGCAGATAGAGGTCAAGAGGAGCATTTTCATCTCTTCTTTTGCTGGTCAGAGAAACGGTTCTGAGAT
CACAGAAGCTATGATGCATACCTACAGCTTACAAAAGGGAGAGGAAAAATGTTTATATCATCTAGTAAACAGTTGTAAAATGAGCTTTTA
AATCTAATCTATAGACATATTATTCATTGCTCAGACACCTGTGAACAGTCTTGATACATGCAAGATGTTTGCCAAACTTTGTAATCCTTT
CTACTAGCTATAAGAGAGGATTTAAGAACTGGTGTAGGACTTGTTGCCATCACCACCAGTTTCTAACAGATCTTTTATAACATTCACATA
AGTACTGTAGACAGTAGTAGACTTAAACTCTCCGTTTCTCTCAGTATTTTAGCTAAGAATGTTACCATATTTTTCTCTTAACAATTCCAT
CTCAGGTTGCTGCTGCTTGTCTAGTTTAAAAGGTCAGATCTATTAATCAGGAATGAAATTTTATTTGGGATTCAGTGTTAGACAAACAAC
AAAATGATGCGTGGCAGAAGTCATCTTTTTATTCTGGCTGGTCCAGGGAACAAGAAAACTGCTGCTGGACCAGCAAGGGAAGAGTTTCTG
TCTGTCTTAACAGAAATCTGTCCCCAAGACAAAGGGGTACTTGACTCCTACAAAACTTAAAGGGTACATTCTCTATCTGATGAGGAGGTA
CTCATTATGGCCTTCTGGAAAGAGGCTATGTTAGTGATCTGGTCTTTACAGATTTAGAGTCATGTTATTTGAAAGCTAGAATAGACAACC
TATAAAATGCTTACCAACATGTGTCAGTACACGTTTATGTTTATATGAAAAAAAATTTCTAGCCACAGTGTCTTATGATTTTGTATTGAA
GCAAACAGTAGGAATTTTGGAAAAATAGAGAGTAAGAATGTGTGTTCTATGGAACACTGCTCCACTGAGAAGGTCCATGTAAAAAGGATT
AGGTGGTCATATAAGTTTGGGGAACATAAGCTCACTTGTCCTTTCCTGGAGATTCATGGTATATAATATTCAAAGCTCTGAGAAATTCTG
AAGTTAAAAACAATTGTTAAATTCTGCTTAAATTAGTGTTTTCCTGATATTTGTTTTTTGAACACCTTTTATATAATCCCTTCTAATATA
TACTTAGTATATACTTAATATAATATTGGGAAAATTGTTACTCCAAAGCACATCTTGACATGACATAGTTTCTTAAAAATCCAAATTTTC
TGGAACTCAGAAATTTCCTAATATTTAGCACACTGTCTTCTTTTGCACAGCACTTTTTGCTTTGTGCCATATAGCATTACTCTGTACCTT
CACAGTATTTCATCTGAGCCACTGAGGAAAGTTAAAGGTTGCACTTCCATTTTACAGTTAAGAAAACAAGCTCACCTTAGGCATGGTTAC
TTAATTAATTTCAGAATTAAATTTCAGGTTTCCTTAGTCCAGATTGTCCTGATGTGTATTCTGACACCTAAAATTATATAAACATTTATG
GGATGCTTATTTTACTAAGACTAGAATGGTGGCTACCTGGCTAATAACATTCATCATTGGTTATTCTGGGCATATCATGACTTTATTCCC
GTTGCTTACCATCTACCTGGGACACATCTCTCTTTGATTAAATATATTCTTTTTCTTTGTACTTTTTAGGTAGACAGAGAATGTAGATCA
TTGAAAGCATTATTTATTCCTAAGATTGGCAGGCACAGAATCATTTTTAAGAACCAAATACCCAGTCCTGCCTTAAAGGCCACATCTATG
ATCATCAGCTCTGTTAGAAATAACAGCCTGGCATAATTCCTAAATACAAGTCTGTAGATATATCCAGGAGATAGGGTTACACTGTTTTCT
AACCTTTTTTAAATCCCTTAATCTTGAGGTAAACTGCATGCATTTAGTCAAACAAGCATCATAAAATTTGTTTCCTCACTGTTTGGGCTT
AACCTCCTGATAGCCTGTTTTACTGAATAACTTGACCCTAACCTGTAGAGAATAAGAGCATTCAAATTAGGAAGGCAGGACTATCCATCT
TTAGTGCTTTTCCTGCCGTTAAACAACAATGTGAACTTGGTCAAGTCATTTCTGTTCTTTATCTGTGACATGAGGTAACTGTATTAAATT
TTCAGCATCAAATCCAGCTATAAATTTGTATTTTGTAAACAAGAGAAAGTAAAGCAGGAGACAGAATGGAGAAGCTGGATAGTGTTTTTT
TTTTTTTTTTTTAAGGTTCTTTTATCATCAGATATGACACAAAGGGAAACATCAAAATGCACCGTAAAGTTAAATCCTAGTTACCTTTTT
TTGAAGCTGTTGGCAAGGTTTGACCACTTGGGGCATCTTCTGCTGTGAGATGACACTTGAAAAACACCCATCAAAGTTTTCCTGGTAGGA
ATCTCTCTTTACTGCGTGTTTTTTTGAAAAGCTGACAGAGAATATGCTTTGGCTTTGACACTAATGAAGTCACCCATCATCAATTACATA
CAGCTAATTGTTGGGAGCTAGAGCTAGAATCCAAGCTTTCTGATTCTCTGCATGGAAGAGGAAATGCTCTAGGGCCCTTCAGGGCAAATC
TTAAAAGGAAGTTCTTGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACGAGATCAGGA
GATCGAGACCATCTTGGCTAACACGGTGAAACCCCATCTCTACTAAAAATACAACAAATTAGCTGGGCGCGGTGGCGGGTGCCTGTAGTC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATAGTGCCACTGCACTCCGGC
CTGGTGAAAGAGCGAGACTCAGTCTCAAAAAAAAAAAAAAAAGGAAGTTCTTAGTGTGTAATTGACCATCAGGGATAAATGGGCTTCAAA
AGTGTTAATTGTCTCCTTACTTACAGTGAGTTTCTAGAGATAGCCCTGTCTTTCAGAAATTCTCTGACATCTGCTTGCGCAATGTTATAA
CCACTTTCCCACACTACTCCCCTCCAGAAATCTCATTGATATGTGGCGAGGACACGCCTTAGCTATCACCCCAATGGATGCTTCTTTCAT
TGACCCAAATCCAGAATGTAATGGGGAACTGAATACAAGTTGGATGTCTCCACCCTTGGAAAGCACATCTTTTGTTCTTACTGAAGTAGT
TTAACACCACCAGATGATCAAGGGATCAGGGTATCTTTCTGGTATCTTTTTAATCACTGAAGGACTTTGACAGCAGTAATGGTGGCATTG
TTGACTCTTAAATTTCTGAACGTTTCACTTAATGGCAAGTGAAGAGATATAGAATCCCCCAAAGAGTGTCAAGATGCTAACTTCCAACCC
TATTTTTATGTACTGAAGAGGCCTCAGTGTCTCACTGAACTCTAACCTTTTTGTCAGTGTTCCTCAACACTGGATGCGTATTATTACATA
ACCTGAGGAGTTAAAAAATACAATAACCAGATGTCCAATTAAATAAAATTAGAATCTGGAGGAGGTAGAACTCAAGCATTTACAGTTTTG
TTTTGTTTTTTTTTTAAGACAGAGTCTCGCTCTGTCCCCAAGTGCAGTGGCACAATCTCGGCTCACTGCAAGCTCCGCTTCGTGGGTTCA
CGCCATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTTTTTTGTACTTTTTAGTAGAG
ACAGGGTTTCACTGTGTTATACAGGATGGTCTCGATCTCCCGACCTCATGATCCGCCCGCCTCGGCCTCTCAGAGTGCTGGGATTACAGG
CGTGAGCCACCACGCCCGGCAAGCATTTACAGTTTTAAATCTCCCAGTCAGAATAAATTCTTATTGAGGGCCATACCTAGCCTGTCTTCA
TCAAACTCATAGGTGAATCTTTGTCAAACCTATAGGAGAGAGATGCAGGCCATAGAGATGGTCTTGCTGAAGGTCTTATAGCTAAATTAG
TTCAGATCCAGGAACCAGATTCTGGAACTGATTGCACCTATATTATGTTGTGTGTCAGACACTCCCAGGACCTGTTTGGTAATAATTAGG
ACAGCTGACATACTTGTTGCTAATTTTGAGATCTGGGCAACAACTGTGTAGGCTGTTCTTTCAACCTCTTTCTTCTTACTTCTTTACTTT
TCCTTCAGAGAGGAGAAAGCCACCCCTGTGCTATAGCCACCGCTCCAATTCTGACTCTAGCTAGGTCATGAAACAGACTGAGCTATTATT
GCATCAACACATAAATCCTGTCATTTGGGTATTATTCTTTAGAGAACTAGAGATTACCTAGCTGCAACCTAAGTTTCCTGAATTAGAATC
ATTTGAGCAGCACCATCTTAATTGGCTCATTAACATATTTGTGACCAGGCACAGTGGCGCATGCCTGTAATCCCAGCACTTTGGGAGGCC
GAGGCGGGCGGATCTCTTGAGGTCAGGAGTTTGAGACCAGCGTGGCCAACATGGTGAAACCCCATTTCTACTAAAAATGTAAAAATTAGC
TGGGCTTGGTGGCGCGCGCCTGTAATCCCAGCTACTCGGAAGGCTGAGGTGTGAGAATCACTTAAACCCGGGAGATGGAGGTTGCAGTGA
GCAGAGATTGCGCCACTGCACTCCAGCCTAGGTGACAAGAATGAGACTCCGTCTTAAAACAAAAACAACATATTTGTTCACTTTTGAACC
CTGTGGTGTCTTTTAACTTTGTTAAGGGCCCTTGGTTAGCAAAATTATGAAAGTTTAGGAAATTTGGCTATTGAGTATATTAAGTACAAC
TACAAAATCCTCTGAGTTCTCCAGGAAGCCTAAACCTTGAGCAGTATCTTATTCAAGTGGAGTATATATCTTCAAGAATACAGATTTTTA
AGGTAAGTAGTTTTTCGTCTTTGCATCTCCTAAGACCATTGTTAACAACCTTGATATTAAACGAAGAAGTGAATGTAAACCTCCTTTTGA
ACATATTTTTTATAAAGAAATATTTTGTTAATTGGAGTAAGTAGTATTGTTATGAAATCACTGTGTAATTGTTAATTGTAAACTGCAATG
TCTATTTTGTGTTGTAACAATGTTGCCATAAAATAGCTTTGCTAAATGTGAAATGACTTTAATCCCTTTTGTCTTCAATATACTTCATAA
AGGAGGAAATGATGATTTACACAATTTGTCATGAAGCTTCCGTGTTTATGAGAAATTCCAAGAAGTAAGAGCCAAGAGGACAGATATTAT
CAGAATATGGGACATAAGAAATTGCATATAGTGTCAAGGGTTTCTATATAACAACTTAATTTATTTCCCTTGCATATATAGTAGGGGTTA
ACATTTTGCTCAATGTTAACGGGGGACATAATGGACATAAAACATTGGATAGCTTTTTATTTAAATGAGCTAAAGGTGTGCGTATACACA

>43360_43360_4_KPNA1-GMPS_KPNA1_chr3_122215284_ENST00000344337_GMPS_chr3_155637022_ENST00000496455_length(amino acids)=374AA_BP=85
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQGKVIE
PLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM
QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLR
QADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KPNA1-GMPS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KPNA1-GMPS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KPNA1-GMPS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource