FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:KPNA1-GOLGB1 (FusionGDB2 ID:43361)

Fusion Gene Summary for KPNA1-GOLGB1

check button Fusion gene summary
Fusion gene informationFusion gene name: KPNA1-GOLGB1
Fusion gene ID: 43361
HgeneTgene
Gene symbol

KPNA1

GOLGB1

Gene ID

3836

2804

Gene namekaryopherin subunit alpha 1golgin B1
SynonymsIPOA5|NPI-1|RCH2|SRP1GCP|GCP372|GOLIM1
Cytomap

3q21.1

3q13.33

Type of geneprotein-codingprotein-coding
Descriptionimportin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2golgin subfamily B member 1372 kDa Golgi complex-associated proteingiantingolgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1golgi integral membrane protein 1golgin B1, golgi integral membrane protein
Modification date2020031320200313
UniProtAcc

P52294

Q14789

Ensembl transtripts involved in fusion geneENST00000344337, ENST00000466923, 
ENST00000472829, ENST00000340645, 
ENST00000393667, 
Fusion gene scores* DoF score19 X 10 X 13=247012 X 11 X 4=528
# samples 2613
** MAII scorelog2(26/2470*10)=-3.24792751344359
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KPNA1 [Title/Abstract] AND GOLGB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKPNA1(122215283)-GOLGB1(121388202), # samples:1
KPNA1(122215284)-GOLGB1(121388202), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KPNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLGB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04U-01AKPNA1chr3

122215284

-GOLGB1chr3

121388202

-
ChimerDB4BRCATCGA-A2-A04UKPNA1chr3

122215283

-GOLGB1chr3

121388202

-


Top

Fusion Gene ORF analysis for KPNA1-GOLGB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344337ENST00000472829KPNA1chr3

122215284

-GOLGB1chr3

121388202

-
5CDS-intronENST00000344337ENST00000472829KPNA1chr3

122215283

-GOLGB1chr3

121388202

-
In-frameENST00000344337ENST00000340645KPNA1chr3

122215284

-GOLGB1chr3

121388202

-
In-frameENST00000344337ENST00000340645KPNA1chr3

122215283

-GOLGB1chr3

121388202

-
In-frameENST00000344337ENST00000393667KPNA1chr3

122215284

-GOLGB1chr3

121388202

-
In-frameENST00000344337ENST00000393667KPNA1chr3

122215283

-GOLGB1chr3

121388202

-
intron-3CDSENST00000466923ENST00000340645KPNA1chr3

122215284

-GOLGB1chr3

121388202

-
intron-3CDSENST00000466923ENST00000340645KPNA1chr3

122215283

-GOLGB1chr3

121388202

-
intron-3CDSENST00000466923ENST00000393667KPNA1chr3

122215284

-GOLGB1chr3

121388202

-
intron-3CDSENST00000466923ENST00000393667KPNA1chr3

122215283

-GOLGB1chr3

121388202

-
intron-intronENST00000466923ENST00000472829KPNA1chr3

122215284

-GOLGB1chr3

121388202

-
intron-intronENST00000466923ENST00000472829KPNA1chr3

122215283

-GOLGB1chr3

121388202

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344337KPNA1chr3122215283-ENST00000340645GOLGB1chr3121388202-220530651923290
ENST00000344337KPNA1chr3122215283-ENST00000393667GOLGB1chr3121388202-221630651938295
ENST00000344337KPNA1chr3122215284-ENST00000340645GOLGB1chr3121388202-220530651923290
ENST00000344337KPNA1chr3122215284-ENST00000393667GOLGB1chr3121388202-221630651938295

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344337ENST00000340645KPNA1chr3122215283-GOLGB1chr3121388202-0.0139916020.98600835
ENST00000344337ENST00000393667KPNA1chr3122215283-GOLGB1chr3121388202-0.0145916820.98540837
ENST00000344337ENST00000340645KPNA1chr3122215284-GOLGB1chr3121388202-0.0139916020.98600835
ENST00000344337ENST00000393667KPNA1chr3122215284-GOLGB1chr3121388202-0.0145916820.98540837

Top

Fusion Genomic Features for KPNA1-GOLGB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for KPNA1-GOLGB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:122215283/chr3:121388202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KPNA1

P52294

GOLGB1

Q14789

FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.FUNCTION: May participate in forming intercisternal cross-bridges of the Golgi complex.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-21425_2843539.0Compositional biasNote=Poly-Arg
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-21425_2843539.0Compositional biasNote=Poly-Arg
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516223257_325930543260.0Topological domainLumenal
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716223257_325930593270.0Topological domainLumenal
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516223257_325930543260.0Topological domainLumenal
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716223257_325930593270.0Topological domainLumenal
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516223236_325630543260.0TransmembraneHelical
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716223236_325630593270.0TransmembraneHelical
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516223236_325630543260.0TransmembraneHelical
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716223236_325630593270.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-2141_5743539.0DomainIBB
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-2141_5743539.0DomainIBB
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-21442_5143539.0MotifNuclear localization signal
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-21442_5143539.0MotifNuclear localization signal
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214149_24143539.0RegionNLS binding site (major)
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214245_43743539.0RegionNote=Binding to RAG1
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214318_40643539.0RegionNLS binding site (minor)
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214149_24143539.0RegionNLS binding site (major)
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214245_43743539.0RegionNote=Binding to RAG1
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214318_40643539.0RegionNLS binding site (minor)
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214118_16143539.0RepeatNote=ARM 2
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214162_20643539.0RepeatNote=ARM 3
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214207_24543539.0RepeatNote=ARM 4
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214246_29043539.0RepeatNote=ARM 5
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214291_33043539.0RepeatNote=ARM 6
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214331_37243539.0RepeatNote=ARM 7
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214373_41243539.0RepeatNote=ARM 8
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214413_45743539.0RepeatNote=ARM 9
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-214460_50443539.0RepeatNote=ARM 10%3B atypical
HgeneKPNA1chr3:122215283chr3:121388202ENST00000344337-21477_11743539.0RepeatNote=ARM 1%3B truncated
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214118_16143539.0RepeatNote=ARM 2
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214162_20643539.0RepeatNote=ARM 3
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214207_24543539.0RepeatNote=ARM 4
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214246_29043539.0RepeatNote=ARM 5
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214291_33043539.0RepeatNote=ARM 6
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214331_37243539.0RepeatNote=ARM 7
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214373_41243539.0RepeatNote=ARM 8
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214413_45743539.0RepeatNote=ARM 9
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-214460_50443539.0RepeatNote=ARM 10%3B atypical
HgeneKPNA1chr3:122215284chr3:121388202ENST00000344337-21477_11743539.0RepeatNote=ARM 1%3B truncated
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516221062_124530543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516221301_177930543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516221828_318530543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST00000340645162248_59330543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST000003406451622677_102830543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716221062_124530593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716221301_177930593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716221828_318530593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST00000393667162248_59330593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST000003936671622677_102830593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516221062_124530543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516221301_177930543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516221828_318530543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST00000340645162248_59330543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST000003406451622677_102830543260.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716221062_124530593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716221301_177930593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716221828_318530593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST00000393667162248_59330593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215284chr3:121388202ENST000003936671622677_102830593270.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516222420_242330543260.0Compositional biasNote=Poly-Glu
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516222993_299630543260.0Compositional biasNote=Poly-Ser
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716222420_242330593270.0Compositional biasNote=Poly-Glu
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716222993_299630593270.0Compositional biasNote=Poly-Ser
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516222420_242330543260.0Compositional biasNote=Poly-Glu
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516222993_299630543260.0Compositional biasNote=Poly-Ser
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716222420_242330593270.0Compositional biasNote=Poly-Glu
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716222993_299630593270.0Compositional biasNote=Poly-Ser
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000034064516221_323530543260.0Topological domainCytoplasmic
TgeneGOLGB1chr3:122215283chr3:121388202ENST0000039366716221_323530593270.0Topological domainCytoplasmic
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000034064516221_323530543260.0Topological domainCytoplasmic
TgeneGOLGB1chr3:122215284chr3:121388202ENST0000039366716221_323530593270.0Topological domainCytoplasmic


Top

Fusion Gene Sequence for KPNA1-GOLGB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43361_43361_1_KPNA1-GOLGB1_KPNA1_chr3_122215283_ENST00000344337_GOLGB1_chr3_121388202_ENST00000340645_length(transcript)=2205nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACC
AGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCG
GGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCG
CAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGAC
CAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCT
ATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGG
AAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATT
CTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCTTTGGACCACTCCCCTCAAAACTTGGAATTCTCTCACCTCTAACATCAGAA
CATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTTCTCTCCAACTCTTCACGGAAAGTGCCTGCAAAAACAGAGGTGGATACGAG
GACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTTCTACTGCCCTGAGCCTGAACGCTTCTGCTTAATCTGAGAATCACATTTGG
TTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCTGATCTTTTGTGGTCCTGTAAAAGATACTGAGGAATGTCTTTCAGCCAAGC
CAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCAGTATCATTTTGATTGATAACTTTCTTTGCCTTGTTTGCCTGTATTTTCTC
CTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTCAGGGAAATGAACATGTCACCTCATAGGACATCTGATTTAGGTCTCTTGCA
GAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTTTAGCTGTTAGATCACATGGGAGGACAGCATCTTCTTCCCTGCCAATTTCA
GATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAGGATAGAATCCCTTTGCTTTTGCCCTTGATCACATGTATACTAAGGTATTA
AGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAAGTGTCTATGGACAGCAGGGTTCCAATTCTTGTCATTCCAGGAATATCTGA
ATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGCCACTGGGAGCCAATATTAGGCATTGACTCTCAGCCAGGAGTCTGACTGGT
CTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAAGCTACTTTGCTGTTAGTGACAGTTATTACAGTTTCTCAGCCCCATTGTCT
CTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACAAAATTAAATATAGATAGACCTGAGAAGGACAGCCAGGATAGAATTCCATT
TGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTACCAGTTGGTTATTTTCTCATTGCATACGTGATGTGTTCACTGCCTAGCCTC
TCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTGCTCTAAATCTACTGTGGTGATTAAATCTTGGTTACAACATCCTGGGAAGT

>43361_43361_1_KPNA1-GOLGB1_KPNA1_chr3_122215283_ENST00000344337_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=290AA_BP=84
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQFSQLL
EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQE
VNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLL

--------------------------------------------------------------
>43361_43361_2_KPNA1-GOLGB1_KPNA1_chr3_122215283_ENST00000344337_GOLGB1_chr3_121388202_ENST00000393667_length(transcript)=2216nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACC
AGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCG
GTGAGTAAAGAGAAGGGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAG
GAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTG
GAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGAC
TCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGG
AGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATT
CATGTCCTGCTCATTCTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCTTTGGACCACTCCCCTCAAAACTTGGAATTCTCTCA
CCTCTAACATCAGAACATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTTCTCTCCAACTCTTCACGGAAAGTGCCTGCAAAAAC
AGAGGTGGATACGAGGACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTTCTACTGCCCTGAGCCTGAACGCTTCTGCTTAATCT
GAGAATCACATTTGGTTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCTGATCTTTTGTGGTCCTGTAAAAGATACTGAGGAAT
GTCTTTCAGCCAAGCCAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCAGTATCATTTTGATTGATAACTTTCTTTGCCTTGTT
TGCCTGTATTTTCTCCTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTCAGGGAAATGAACATGTCACCTCATAGGACATCTGA
TTTAGGTCTCTTGCAGAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTTTAGCTGTTAGATCACATGGGAGGACAGCATCTTCT
TCCCTGCCAATTTCAGATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAGGATAGAATCCCTTTGCTTTTGCCCTTGATCACATG
TATACTAAGGTATTAAGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAAGTGTCTATGGACAGCAGGGTTCCAATTCTTGTCAT
TCCAGGAATATCTGAATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGCCACTGGGAGCCAATATTAGGCATTGACTCTCAGCC
AGGAGTCTGACTGGTCTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAAGCTACTTTGCTGTTAGTGACAGTTATTACAGTTTC
TCAGCCCCATTGTCTCTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACAAAATTAAATATAGATAGACCTGAGAAGGACAGCCA
GGATAGAATTCCATTTGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTACCAGTTGGTTATTTTCTCATTGCATACGTGATGTGT
TCACTGCCTAGCCTCTCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTGCTCTAAATCTACTGTGGTGATTAAATCTTGGTTAC

>43361_43361_2_KPNA1-GOLGB1_KPNA1_chr3_122215283_ENST00000344337_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=295AA_BP=84
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQFSQLL
EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLC
NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRT

--------------------------------------------------------------
>43361_43361_3_KPNA1-GOLGB1_KPNA1_chr3_122215284_ENST00000344337_GOLGB1_chr3_121388202_ENST00000340645_length(transcript)=2205nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACC
AGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCG
GGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAGGAACTAAGGGAACCG
CAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTGGAAGAAGAACGAGAC
CAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGACTCTTCCCGGACTCCT
ATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGGAGTGGCGTTGGATGG
AAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATTCATGTCCTGCTCATT
CTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCTTTGGACCACTCCCCTCAAAACTTGGAATTCTCTCACCTCTAACATCAGAA
CATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTTCTCTCCAACTCTTCACGGAAAGTGCCTGCAAAAACAGAGGTGGATACGAG
GACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTTCTACTGCCCTGAGCCTGAACGCTTCTGCTTAATCTGAGAATCACATTTGG
TTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCTGATCTTTTGTGGTCCTGTAAAAGATACTGAGGAATGTCTTTCAGCCAAGC
CAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCAGTATCATTTTGATTGATAACTTTCTTTGCCTTGTTTGCCTGTATTTTCTC
CTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTCAGGGAAATGAACATGTCACCTCATAGGACATCTGATTTAGGTCTCTTGCA
GAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTTTAGCTGTTAGATCACATGGGAGGACAGCATCTTCTTCCCTGCCAATTTCA
GATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAGGATAGAATCCCTTTGCTTTTGCCCTTGATCACATGTATACTAAGGTATTA
AGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAAGTGTCTATGGACAGCAGGGTTCCAATTCTTGTCATTCCAGGAATATCTGA
ATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGCCACTGGGAGCCAATATTAGGCATTGACTCTCAGCCAGGAGTCTGACTGGT
CTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAAGCTACTTTGCTGTTAGTGACAGTTATTACAGTTTCTCAGCCCCATTGTCT
CTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACAAAATTAAATATAGATAGACCTGAGAAGGACAGCCAGGATAGAATTCCATT
TGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTACCAGTTGGTTATTTTCTCATTGCATACGTGATGTGTTCACTGCCTAGCCTC
TCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTGCTCTAAATCTACTGTGGTGATTAAATCTTGGTTACAACATCCTGGGAAGT

>43361_43361_3_KPNA1-GOLGB1_KPNA1_chr3_122215284_ENST00000344337_GOLGB1_chr3_121388202_ENST00000340645_length(amino acids)=290AA_BP=84
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQFSQLL
EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQE
VNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLL

--------------------------------------------------------------
>43361_43361_4_KPNA1-GOLGB1_KPNA1_chr3_122215284_ENST00000344337_GOLGB1_chr3_121388202_ENST00000393667_length(transcript)=2216nt_BP=306nt
GCCGGCTGAGCTGAGTCTCGCTGCTCGGTGCGAGGCGGCGGAGAGCGAGGCCTGGTGAGCACCGCCGAGGCGCGGGCCAGCTCTTCGAGG
TTGTGCGCGGGAGTGGCACGGCGGGCGGGCGAGCGAGGGGCTAACTTCAGCGGTGGCACCGGGATCGGTTGCCTTGAGCCTGAAATCATG
ACCACCCCAGGAAAAGAGAACTTTCGCCTGAAAAGTTACAAGAACAAATCTCTGAATCCCGATGAGATGCGCAGGAGGAGGGAGGAAGAA
GGACTGCAGTTACGAAAGCAGAAAAGAGAAGAGCAGTTCTCTCAGCTACTGGAAGAGAAAAACACCCTTTCCATTCAGCTCTGCGATACC
AGTCAGAGTCTTCGTGAGAACCAGCAGCACTATGGTGACCTTTTAAATCACTGTGCAGTCTTGGAGAAGCAGGTTCAAGAGCTGCAGGCG
GTGAGTAAAGAGAAGGGGCCACTAAATATAGATGTTGCTCCAGGAGCTCCCCAGGAAAAGAATGGAGTTCACAGAAAGAGTGACCCTGAG
GAACTAAGGGAACCGCAGCAAAGCTTTTCTGAAGCTCAGCAGCAGCTATGCAACACCAGACAGGAAGTGAATGAATTAAGGAAGCTGCTG
GAAGAAGAACGAGACCAAAGAGTGGCTGCTGAGAATGCTCTCTCTGTGGCCGAGGAGCAGATCAGACGGTTAGAGCACAGTGAATGGGAC
TCTTCCCGGACTCCTATCATTGGCTCCTGTGGCACTCAGGAGCAGGCACTGTTAATAGATCTTACAAGCAACAGTTGTCGAAGGACCCGG
AGTGGCGTTGGATGGAAGCGAGTCCTGCGTTCACTCTGTCATTCACGGACCCGAGTGCCACTTCTAGCAGCCATCTACTTTCTAATGATT
CATGTCCTGCTCATTCTGTGTTTTACGGGCCATCTATAGACTTAGTTGTTACTCTTTGGACCACTCCCCTCAAAACTTGGAATTCTCTCA
CCTCTAACATCAGAACATCAATTCCAGTGGAACAGTCTTCCCATTTACAGGTCTTCTCTCCAACTCTTCACGGAAAGTGCCTGCAAAAAC
AGAGGTGGATACGAGGACAGGTTGGAGCTGCAGGGACTGGCGAGTCTGCTTTCTTCTACTGCCCTGAGCCTGAACGCTTCTGCTTAATCT
GAGAATCACATTTGGTTTGTTGAGCCTAATATTTGTTGAGATTTTGCAGGACCCTGATCTTTTGTGGTCCTGTAAAAGATACTGAGGAAT
GTCTTTCAGCCAAGCCAAGAGGATGGTTTCAATAAACCTAATAATCTGAAGTTCAGTATCATTTTGATTGATAACTTTCTTTGCCTTGTT
TGCCTGTATTTTCTCCTGTTTCAGGGGGAAGGTGGCTCTGCCATAAACAGAGTTCAGGGAAATGAACATGTCACCTCATAGGACATCTGA
TTTAGGTCTCTTGCAGAATAGGGTGGTGAAAGCTGAAGGAACTCCCTAGGGGTTTTAGCTGTTAGATCACATGGGAGGACAGCATCTTCT
TCCCTGCCAATTTCAGATATAATTGGAGGGAGAATTTCAGGTCTTAGACTATAAGGATAGAATCCCTTTGCTTTTGCCCTTGATCACATG
TATACTAAGGTATTAAGTGGCCCAAGTCTTTCCTTTCACCAAAGGGCAGGGAGAAGTGTCTATGGACAGCAGGGTTCCAATTCTTGTCAT
TCCAGGAATATCTGAATATTCCTGGAATGTGGACCCTGAGACAGTGCTCAGGGGCCACTGGGAGCCAATATTAGGCATTGACTCTCAGCC
AGGAGTCTGACTGGTCTAACACCACACTGCAACTCCTGACCTCTTGAAGTACTAAGCTACTTTGCTGTTAGTGACAGTTATTACAGTTTC
TCAGCCCCATTGTCTCTGCCCTCTGTGGCAATGGAAGGAGAATATAGAGAAGACAAAATTAAATATAGATAGACCTGAGAAGGACAGCCA
GGATAGAATTCCATTTGTGCCTATTCCCTGCCTCCCCTCCCCTCCCCCATCCTACCAGTTGGTTATTTTCTCATTGCATACGTGATGTGT
TCACTGCCTAGCCTCTCCCTAAAGAAGAGAGAAGACAAGTGGGCTGACTGATCTGCTCTAAATCTACTGTGGTGATTAAATCTTGGTTAC

>43361_43361_4_KPNA1-GOLGB1_KPNA1_chr3_122215284_ENST00000344337_GOLGB1_chr3_121388202_ENST00000393667_length(amino acids)=295AA_BP=84
MVSTAEARASSSRLCAGVARRAGERGANFSGGTGIGCLEPEIMTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQFSQLL
EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAVSKEKGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLC
NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KPNA1-GOLGB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for KPNA1-GOLGB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for KPNA1-GOLGB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource