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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ANK1-ANK1 (FusionGDB2 ID:4343)

Fusion Gene Summary for ANK1-ANK1

Fusion gene summary

Fusion gene information	Fusion gene name: ANK1-ANK1
	Fusion gene ID: 4343
		Hgene	Tgene
	Gene symbol	ANK1	ANK1
	Gene ID	286	286
	Gene name	ankyrin 1	ankyrin 1
	Synonyms	ANK\|SPH1\|SPH2	ANK\|SPH1\|SPH2
	Cytomap	8p11.21	8p11.21
	Type of gene	protein-coding	protein-coding
	Description	ankyrin-1ANK-1ankyrin 1, erythrocyticankyrin-Rerythrocyte ankyrin	ankyrin-1ANK-1ankyrin 1, erythrocyticankyrin-Rerythrocyte ankyrin
	Modification date	20200313	20200313
	UniProtAcc	P16157	P16157
	Ensembl transtripts involved in fusion gene	ENST00000265709, ENST00000289734, ENST00000314214, ENST00000347528, ENST00000352337, ENST00000379758, ENST00000396942, ENST00000396945, ENST00000457297, ENST00000521407, ENST00000522231, ENST00000522543,	ENST00000265709, ENST00000289734, ENST00000347528, ENST00000352337, ENST00000379758, ENST00000396942, ENST00000396945, ENST00000314214, ENST00000457297, ENST00000521407, ENST00000522231, ENST00000522543,
Fusion gene scores	* DoF score	8 X 10 X 4=320	15 X 9 X 9=1215
	# samples	9	18
	** MAII score	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1215*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANK1 [Title/Abstract] AND ANK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANK1(41530409)-ANK1(41542160), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ANK1	GO:0006888	ER to Golgi vesicle-mediated transport	18768923
Tgene	ANK1	GO:0006888	ER to Golgi vesicle-mediated transport	18768923

Fusion gene breakpoints across ANK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BI030456	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+

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Fusion Gene ORF analysis for ANK1-ANK1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000265709	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000265709	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000265709	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000265709	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000265709	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000265709	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000265709	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000289734	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000314214	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000347528	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000352337	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000379758	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396942	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000396945	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000457297	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000521407	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522231	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000265709	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000289734	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000347528	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000352337	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000379758	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000396942	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-3CDS	ENST00000522543	ENST00000396945	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000265709	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000265709	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000265709	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000265709	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000265709	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000289734	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000289734	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000289734	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000289734	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000289734	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000314214	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000314214	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000314214	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000314214	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000314214	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000347528	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000347528	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000347528	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000347528	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000347528	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000352337	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000352337	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000352337	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000352337	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000352337	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000379758	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000379758	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000379758	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000379758	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000379758	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396942	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396942	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396942	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396942	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396942	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396945	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396945	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396945	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396945	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000396945	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000457297	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000457297	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000457297	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000457297	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000457297	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000521407	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000521407	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000521407	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000521407	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000521407	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522231	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522231	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522231	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522231	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522231	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522543	ENST00000314214	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522543	ENST00000457297	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522543	ENST00000521407	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522543	ENST00000522231	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+
intron-intron	ENST00000522543	ENST00000522543	ANK1	chr8	41530409	-	ANK1	chr8	41542160	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ANK1-ANK1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ANK1-ANK1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41530409/:41542160)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANK1 P16157	ANK1 P16157
FUNCTION: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269\|PubMed:12456646}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269\|PubMed:12527750}.	FUNCTION: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269\|PubMed:12456646}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269\|PubMed:12527750}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ANK1-ANK1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANK1-ANK1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ANK1-ANK1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ANK1-ANK1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source