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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KRAS-ETNK1 (FusionGDB2 ID:43430) |
Fusion Gene Summary for KRAS-ETNK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KRAS-ETNK1 | Fusion gene ID: 43430 | Hgene | Tgene | Gene symbol | KRAS | ETNK1 | Gene ID | 3845 | 55500 |
| Gene name | KRAS proto-oncogene, GTPase | ethanolamine kinase 1 | |
| Synonyms | 'C-K-RAS|C-K-RAS|CFC2|K-RAS2A|K-RAS2B|K-RAS4A|K-RAS4B|K-Ras|K-Ras 2|KI-RAS|KRAS1|KRAS2|NS|NS3|OES|RALD|RASK2|c-Ki-ras|c-Ki-ras2 | EKI|EKI 1|EKI1|Nbla10396 | |
| Cytomap | 12p12.1 | 12p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GTPase KRasK-ras p21 proteinKirsten rat sarcoma viral oncogene homologKirsten rat sarcoma viral proto-oncogenePR310 c-K-ras oncogenec-Kirsten-ras proteincellular c-Ki-ras2 proto-oncogenecellular transforming proto-oncogeneoncogene KRAS2transformi | ethanolamine kinase 1putative protein product of Nbla10396 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P01116 | Q9HBU6 | |
| Ensembl transtripts involved in fusion gene | ENST00000556131, ENST00000256078, ENST00000311936, ENST00000557334, | ENST00000266517, ENST00000335148, | |
| Fusion gene scores | * DoF score | 6 X 2 X 5=60 | 7 X 8 X 3=168 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/60*10)=0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KRAS [Title/Abstract] AND ETNK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KRAS(25398207)-ETNK1(22796696), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | KRAS-ETNK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KRAS-ETNK1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KRAS-ETNK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. KRAS-ETNK1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KRAS-ETNK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ETNK1 | GO:0006646 | phosphatidylethanolamine biosynthetic process | 11044454 |
| Fusion gene breakpoints across KRAS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ETNK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-L5-A4ON | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
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Fusion Gene ORF analysis for KRAS-ETNK1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000556131 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| Frame-shift | ENST00000556131 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| In-frame | ENST00000256078 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| In-frame | ENST00000256078 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| In-frame | ENST00000311936 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| In-frame | ENST00000311936 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| In-frame | ENST00000557334 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| In-frame | ENST00000557334 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000311936 | KRAS | chr12 | 25398207 | - | ENST00000266517 | ETNK1 | chr12 | 22796696 | + | 6950 | 303 | 183 | 1238 | 351 |
| ENST00000311936 | KRAS | chr12 | 25398207 | - | ENST00000335148 | ETNK1 | chr12 | 22796696 | + | 940 | 303 | 183 | 656 | 157 |
| ENST00000557334 | KRAS | chr12 | 25398207 | - | ENST00000266517 | ETNK1 | chr12 | 22796696 | + | 6955 | 308 | 188 | 1243 | 351 |
| ENST00000557334 | KRAS | chr12 | 25398207 | - | ENST00000335148 | ETNK1 | chr12 | 22796696 | + | 945 | 308 | 188 | 661 | 157 |
| ENST00000256078 | KRAS | chr12 | 25398207 | - | ENST00000266517 | ETNK1 | chr12 | 22796696 | + | 6822 | 175 | 55 | 1110 | 351 |
| ENST00000256078 | KRAS | chr12 | 25398207 | - | ENST00000335148 | ETNK1 | chr12 | 22796696 | + | 812 | 175 | 55 | 528 | 157 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000311936 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 3.90E-05 | 0.999961 |
| ENST00000311936 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 0.003838934 | 0.9961611 |
| ENST00000557334 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 3.90E-05 | 0.999961 |
| ENST00000557334 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 0.002918022 | 0.99708194 |
| ENST00000256078 | ENST00000266517 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 3.60E-05 | 0.999964 |
| ENST00000256078 | ENST00000335148 | KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 0.003462653 | 0.9965373 |
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Fusion Genomic Features for KRAS-ETNK1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 1.43E-06 | 0.99999857 |
| KRAS | chr12 | 25398207 | - | ETNK1 | chr12 | 22796696 | + | 1.43E-06 | 0.99999857 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KRAS-ETNK1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:25398207/chr12:22796696) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KRAS | ETNK1 |
| FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269|PubMed:20949621, ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:24623306, ECO:0000305}. | FUNCTION: Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. {ECO:0000269|PubMed:11044454}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000256078 | - | 2 | 6 | 32_40 | 37 | 333.3333333333333 | Motif | Note=Effector region |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000311936 | - | 2 | 5 | 32_40 | 37 | 189.0 | Motif | Note=Effector region |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000256078 | - | 2 | 6 | 10_18 | 37 | 333.3333333333333 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000256078 | - | 2 | 6 | 29_35 | 37 | 333.3333333333333 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000311936 | - | 2 | 5 | 10_18 | 37 | 189.0 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000311936 | - | 2 | 5 | 29_35 | 37 | 189.0 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000256078 | - | 2 | 6 | 116_119 | 37 | 333.3333333333333 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000256078 | - | 2 | 6 | 59_60 | 37 | 333.3333333333333 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000311936 | - | 2 | 5 | 116_119 | 37 | 189.0 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000311936 | - | 2 | 5 | 59_60 | 37 | 189.0 | Nucleotide binding | GTP |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000256078 | - | 2 | 6 | 166_185 | 37 | 333.3333333333333 | Region | Note=Hypervariable region |
| Hgene | KRAS | chr12:25398207 | chr12:22796696 | ENST00000311936 | - | 2 | 5 | 166_185 | 37 | 189.0 | Region | Note=Hypervariable region |
| Tgene | ETNK1 | chr12:25398207 | chr12:22796696 | ENST00000266517 | 0 | 8 | 73_83 | 141 | 453.0 | Compositional bias | Note=Poly-Val | |
| Tgene | ETNK1 | chr12:25398207 | chr12:22796696 | ENST00000335148 | 0 | 3 | 73_83 | 141 | 259.0 | Compositional bias | Note=Poly-Val |
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Fusion Gene Sequence for KRAS-ETNK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >43430_43430_1_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000256078_ETNK1_chr12_22796696_ENST00000266517_length(transcript)=6822nt_BP=175nt CTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGT TGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAATATGATCCAACAATAGAGCTCTT CACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACACCATGGAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGAC TGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGTTGCAGGCTCATGGGTGTGCACCACAACTCTACTGTACCTTCAA TAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAAAGCATGTCTGCAACCCAGCCATTTTCAGGCTAATAGCTCGTCA GCTTGCTAAAATCCATGCTATTCATGCACACAATGGCTGGATCCCCAAATCTAATCTTTGGCTAAAGATGGGAAAGTATTTCTCTCTCAT TCCCACAGGATTTGCAGATGAAGACATTAATAAAAGGTTCCTAAGTGATATCCCAAGCTCTCAGATTCTCCAGGAAGAGATGACTTGGAT GAAGGAGATTCTTTCCAACCTGGGCTCACCTGTTGTGCTTTGCCATAATGACCTATTGTGTAAGAATATAATCTACAATGAGAAACAAGG TGATGTACAGTTCATTGATTATGAATATTCTGGATACAACTACCTGGCATATGATATTGGAAATCATTTCAATGAATTTGCAGGTGTGAG TGATGTAGACTATAGTCTGTATCCAGATAGAGAACTACAGAGTCAGTGGCTGCGTGCTTACCTTGAAGCCTACAAAGAATTTAAGGGCTT TGGGACTGAAGTTACTGAAAAGGAGGTAGAAATACTCTTCATTCAAGTCAATCAGTTTGCATTGGCTTCTCATTTCTTTTGGGGATTGTG GGCTTTGATTCAAGCCAAATACTCCACTATTGAGTTTGATTTCCTTGGGTATGCAATTGTTCGTTTTAACCAGTACTTTAAAATGAAGCC TGAGGTTACTGCATTAAAAGTGCCTGAGTAAAGAAGAGATTTAATTATTCTCCAGTAGCTGAGCAATGCTTGTGAATCTTTTCTTAAGAA ATCCCAAAAAGCCAATATTAGTTAAAATTCTGTTGTTTAATTTGGTTATCTTGCTTTATAAATTATGCCTCTAAACAATCAAATCTATTT TTGAAATAGACTGAATGATGTCAAGAAATATACCTACTGCTATCCGTATGTGGTGGATTAGAAATGTGTTAAATCTGCAAAAGGTATAAA GATGTCAGTTTAATTTCTTTGATAATTTAACCTATGTTGTATGTGAATTATTTATTATAAACTTAGCACGATTCTGTGACTGTTTTTCTC TGTTTCACGTTCGTTGAGTGTAAGCAATGAAAATGTCCCAAATAAGTTTTTTAAGTTTTACTTTAATAAGATTAATTTCAGTAAACATTC TAGTTGTTCAGTGTAACCTTTTTATCTTGATGCATTGTAAGTAAAATGAATCATTTACTCTTGAAATGCCAGTCATTGACTGATGTAGAT AATTTAGGATTTTCATATAAAAATAGCTGTTTAGGAAGGTGAAATACATTCACTGTCTCTGTTGGTGGTACATCTTGTTGAATTCAATAT TAGAAAGTATTTCTTTTTGGGGTAATATAACTTAGAATTAAATCCCTGTTTCTCTATGTAGTCTGGCAGTATAAATATAAATATTTACCA TATAATCTTGGAATAAGTATTAGTTAATGTTACCAAAATCTGTATTAAATAATGTTTTCAAATGCTAAATATGGTCGTTACTATTTTCAG TTTTAAAAATTTTATAGTATCAAATTGTTTCTAACCAAAAATTTCCTTTTACTTCTAGAGATGCTTTATGTTTTTGATTATTAAATAGTC ACTAGTATTGCTAATTTTTGAAACAAATACACAAAATTTATCATATGTAGAAATAAGAAAATATTGTTTAGGTTAATTATTTTTTACCTA TCCAGAGTCATTCCTTACATTTCAGTTTCATGTTTCATTCCTCACATTTTAGTTTCATGTTTTAGTTTGATTCTATGTTTTTAGACTGAT AGCAAATGATTACTTGATACATGTAAGTTCAGCGTTATATGTTGAGGCAGTTATATAATTAAATAAGGAACACTTAGGGCATTGATCTTG TACACTTAAAATCTGACAAATGACAAAATGTGAATTAAGCATAAATAGTCATGGCAGGAGGGCTTTTGTTTATTTCTCTTGTTTTTGTTT AACTGTATTTTTAATTTTGTCTGGTGGTAAGAGGGAGGTAATTATTGTATGGAAAGAAGTTAGATCTTTCAGATAGATAAATAGGCTTCA GGTTTTGAAGTCTGCTCTGTGTAGTTGAGCAGTCATGGTTAACTTTACTTAGAAAATTAGTCTGACAAGCTTTGCACTTCGGTCACATAA GTGCCCATGTACAAAGTTGGCTTACTGGATCTGCATATTCAAAATATGCAACTACAAATTTATCCTCTGAGAAATCTTCTGAGGAGTCTA ATGTATTCCAAATGACTTAATATTCTCAGACAAATGCTTTAAAATACTTGGATTATCTCAAGATTTTTGAAGCTAATAAAGTAAATAGAA ACACAGGCCATTTTAAATGGTAAATTCTAGTTACATAAATATAATCTTAAAGTATGTTTGTATCTGTAACAGTGTTAGACCAGATTTGGT TTCTACCTCCCCAATGTTATAAATGTTCACTTTTGTTTTTATAAACCATATTACTGTAAGATCAATAGAACTTTGCCTAGTTAAGTGAAT GGAACCAATTAAACAACTAGTAGCTTTTTATAATGTTAGTGTGAACTTGAAAAATTGTTTTTGGTGGAATTTTTGTCTGTGGTTAGAACA TTTTCATAAAACAGATAAAGAATGTGTAATACTCTTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTGCTTTCTGCCTTCTAAAGTGCAAC AGTATATATCTTGTAGAACTGTGGGAGGAGAGAAGATAATTTTTCTACCTTACTCCATATTCTTACTTCAAACTATTTTGAATAGAGGTT CACTGAGCCATTGCTGATAGACTGTGCATAGCTACTAGCTGTCACACTATTGTAGGTTTTTTGGAGAGATTCATAGGGAAGTGAATGTAA CCAGGAATAAAGGCTCTCACTTTAGCTCTGGGACTATGCAGTGGATCTTGGGAACAAAATAAGATATCTAATCTATTTTCCCCATTCTGG CTAGATTTTGGTTGTTGTGATGCTCCTACTTCCTGTATAGGTTTTTGGGATCATGGTGCAGGCTAGTAATAGGATTCAGAATTGCTTCCC TTTTATATCGACCATGTAAGGGATTCTAAAGGAGGGTAAATCTCAAAGTGCTCTGAAATCATCCCTCTAAAATCTGTCCTGTGGTGTGCT AAGATGTCTGTTGCCTTTTTATGTTAAGCTAAGGAACTTGAATGCCTTACCTAATAACTCAACTAGTAGTAAGCTCATTTTGTAAATATG AAAATGGCTGTAAGAAGTGGCATTCATGTATATTCAATGTTAGTCAATAGACCATAGTGGCCTGGATGCTTTAACAAGCCAAATTCCGCA ATTTTTTTTCCTTTTTTCCCCTTCATACTTGTATGATCTCACCTGACCAGTGATTTCTTTTCCTCCTAACCCCATGCTACCACCATTTTC TGGAAATCAAAGAGATGTGGTAGTAAATCATACAGTACACACGATCATCTGAGATCAATATGAGCACAAAACTCATCAAGTAGGTCTGCC TGGAATGTATATAAAAAATGTAAATAAAAATTTGTAAATTAGTGTGAACTGTATCTTGCATATGAGACTGTGTATTGTTTTGCATTCTCT TCCCTTTTGTAGAAATTTTTCTGTAAGGAAATGATTCAGCTTGTTGGTTTTAGAGTAAAAATAGCCAACAGTTGTGGCTACACAGTGAGA TCACAGGAACTGGAAATAGGGTTTGTCGGCTTTGGTTAATGTCAGTACTCATTTATTTAGCCTCTCAGTGCTTAATAAGACTTTTCTTTA TTTTTTAGTTAGCCGTTAGGTTTTGTGAGGTTAGATTCCTGGAAGCAGTGAATTTATACACTGTTATATTAATAGAGCTCCGTTCTTTGA GTCATGATTCCAAGCTAAAGGAAATTAAAAATGTAATTTAATAATTTCCTATTTTTAGGGTTGTTAATTTTTTTCTACAAAAAAACCTTG AAATTTTAGATATCCCAATGTGAATCTAATTTCCATATATACAGAAATTAGACAAATAATAAGTCTTTAGTTCAACTTAAGCATATCTCA AATGACTTCTCTAAATTTAAAGTTGATCATGATAGGATCATAAAAGACAGAAAAGACTTAAGTAATCTTGTAATGACAATTATTTCCATT TTTGCTGAACTAAAAATATTTAACTTCATAAATATGTTACTACAGCTTCCAGATTTAAAGAAAAAAAGTTTCCCCCACTCTCAATTAAAA GTTAGAACCCTCCACTTTTAAAATTATACAAATATTTCTTTTTTACATTACACAGAAGCCTTCTGTACCATTTTACGAATTTCTGTCTTC ATAATATAAGTGAAAATACTGTCATTTCAATTTTCTGCTTTAAATTGTTTTTAATAAGCATTCCAAAGTGATACAGACTTAAGCTTTTAA TCAATCAGTCATTCAGTTGATAGACAAAGTTAGCGATGCTTTATGCTAGGAAACTTGTTGACAGTAACCTGTGCGACTTTATGCAGAAGA CAAATGCTAGTAATTATTATGCACAGAGGAAAAATCATTTTAAGTATGTGGTAAAGCAGCTTCATCTTTCAAAATTGATTTGCTCTGGTT TTTCTTTAGTCCATTAGATTCCAGAATGTCCTTTTACTGGGAATTTAGTTATGTATTAAGATAACCTGTTTTCAGTTCTTTTTGAAAAGA AGACATTATTTATATTGAACCACCTTATTTTAAAATTTTTAACTTTTATATACCACTTGTGTGATTCCAGTGTCATGTCTTGGGTTTGAT GTCGTTGGACAGAAAAGTGTATCAATTATTTTAAATGAATTTTTCCCCATGTTTGAGGCTTAGTCTGTAAATGTGTTGCTGTAACAGAAA ATACTTGGGTATGCATTACTTGAATACTTGAAAACTGAAATTAATAAGATGTATTACATAATGAATTAGATTTCTCTGAACAGTTTTTAC ACTGAAAATCTTCATTTCTGGATTGCAGTTTGAAATGGAATGAAGACCTGAATTATTTGGGTAGAAAAAATTATGATAGTGCTTATAAGA ACTGTAAACTGTTTTAAACTATTTTGTGTTTGACGCATCAAACTTCAAGTTTTTTGTAAGTTTCTCTCCTGAAATTTTCTTTCTCTTCTA TACTTTATGCACTTACTATACTACTGATGTAATAAAAGAGCAGGGTTAAAAATATTGTATCTGTATTCATTGTGAATCCTGTAGCTTTTC TAGTTAACAAAAAATCGCTTTCTAAAATACTCTTAATCCCATTGTTTTGGTTAACATCTTACCCATTTGTTGTATTTCAAATGCCATTAA TCATTTTAGTACAACACCTATGTTTATAAAAATTTGAAAACATTACATATTGTATTTAAAACTAATTAGTGAAGAGTAAGAAAAAAACTA GCCAACAGAATTGTAGGTGATGCATTAGTTAAATTTCAAAACTCATAATAAAGGAACTTTCAGAGATTGGTTGAAACCCAGTGGTATCCC TGTAAATTAGCTCCTGTGACTGGAAAAGACCCCAAAAAGGCAGTAGAGGAGATTAGTGTTTACTTGCTGTGGTTGTGGTGTGCTGCTACT TAATTATAGGTAGTGACACACTGAAATTCTTATTTGTCCAATAATCTGAAGTAGTTTCCTATATTTATCTGTACTAAATTGACTATAAAT TGAGTCTGCAAAGAGGAAACTTTTTGACTGTACTGTATTTAGGAGCCTTTGTACAGCTTGGTCAAATTTCCATGATATGAAGTATTTGAG TTTTAAAATATACTGTTATTAAAAGGAAAAAGACATGGCCATTATTCCATGTGCTTAAATGATAATTTCCTTATTCAGTTTCAGAAGAAA AAGAATGAAATTGGGTAACTGTCATTGCGTTAGCTTTATGTTGAATTGGGAAATTGTGGCATAAAGCTTAAATTCGTGTTTATCAAATGT GAACCATAGTAGTATAATGCTGCTTTGTATATAATGTAAGTGCTACAAATAGTCTCAGCACTGAAAATGTATTGATACCTCTTAAATGAA TGCAACTTTTGATGTAGGTGTTTTGCTATGCCTCAGAAAATATCTGTCTGAGAATTTGTTAATCTGTTTGATAATGAAGATACTTCCTGT TTTCTTGTTTCATATTTTCATGTTCAAAATTTAAGTTTTACATTTTTACTACTGTTAATTTAAATAAAATTTGTTCTGTGGATAAAATGA GGTTGGCAGTGAAGAAAATTAAAAACAGCCTCATTCATGTAACTGGTTAAGTAAAAATACATTTTCACTATGTGTTCATAAACTTTTAAT GAAGCTGTTTGTCTTTCAGTTCAAATATAAGTGATGTTTAGGCTTTATTTCTGTTAATAAGGCTTTTTACCATTGATTAAATGAAGGAAT >43430_43430_1_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000256078_ETNK1_chr12_22796696_ENST00000266517_length(amino acids)=351AA_BP=40 MLKMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIELFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQA HGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIP SSQILQEEMTWMKEILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQSQWLR -------------------------------------------------------------- >43430_43430_2_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000256078_ETNK1_chr12_22796696_ENST00000335148_length(transcript)=812nt_BP=175nt CTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGT TGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAATATGATCCAACAATAGAGCTCTT CACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACACCATGGAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGAC TGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGTTGCAGGCTCATGGGTGTGCACCACAACTCTACTGTACCTTCAA TAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAAAGCATGTCTGCAACCCAGCCATTTTCAGTTTATCATCGTTGAC TCTTTGCAAAGGAAAAACTACAAGATGTTTTGGATTAACCGGCTGCAGAGGGTCAAGGCTTCTGCTTAGTTTTTTCTAGTTAGTGTTTGA GTTGAAGTGTTATACATTTCTTACTGCCGATTGCTTATTACTTAATTGTTCATGTTTTCAGAGTTCTTGCCTATTAAAATTTTATTAATT TGGTTAACAATTCTTTGTTCTTTACGTTGTTCATTATTTAATTTAATATATTATGTTTTCTATAAAGAATAATGTCATATATGCTTGATC ATTTTTCCAAAATTGCCAGCTTTAAAAATTCTCTTTCTGCTCTTGAAAACTCTAGAAAATGGTCTGGATTTGAAAACAGCATTCATAGGT >43430_43430_2_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000256078_ETNK1_chr12_22796696_ENST00000335148_length(amino acids)=157AA_BP=40 MLKMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIELFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQA -------------------------------------------------------------- >43430_43430_3_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000311936_ETNK1_chr12_22796696_ENST00000266517_length(transcript)=6950nt_BP=303nt TCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCC CCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGA GGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAAT CATTTTGTGGACGAATATGATCCAACAATAGAGCTCTTCACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACACCATG GAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGACTGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGTTGCAG GCTCATGGGTGTGCACCACAACTCTACTGTACCTTCAATAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAAAGCAT GTCTGCAACCCAGCCATTTTCAGGCTAATAGCTCGTCAGCTTGCTAAAATCCATGCTATTCATGCACACAATGGCTGGATCCCCAAATCT AATCTTTGGCTAAAGATGGGAAAGTATTTCTCTCTCATTCCCACAGGATTTGCAGATGAAGACATTAATAAAAGGTTCCTAAGTGATATC CCAAGCTCTCAGATTCTCCAGGAAGAGATGACTTGGATGAAGGAGATTCTTTCCAACCTGGGCTCACCTGTTGTGCTTTGCCATAATGAC CTATTGTGTAAGAATATAATCTACAATGAGAAACAAGGTGATGTACAGTTCATTGATTATGAATATTCTGGATACAACTACCTGGCATAT GATATTGGAAATCATTTCAATGAATTTGCAGGTGTGAGTGATGTAGACTATAGTCTGTATCCAGATAGAGAACTACAGAGTCAGTGGCTG CGTGCTTACCTTGAAGCCTACAAAGAATTTAAGGGCTTTGGGACTGAAGTTACTGAAAAGGAGGTAGAAATACTCTTCATTCAAGTCAAT CAGTTTGCATTGGCTTCTCATTTCTTTTGGGGATTGTGGGCTTTGATTCAAGCCAAATACTCCACTATTGAGTTTGATTTCCTTGGGTAT GCAATTGTTCGTTTTAACCAGTACTTTAAAATGAAGCCTGAGGTTACTGCATTAAAAGTGCCTGAGTAAAGAAGAGATTTAATTATTCTC CAGTAGCTGAGCAATGCTTGTGAATCTTTTCTTAAGAAATCCCAAAAAGCCAATATTAGTTAAAATTCTGTTGTTTAATTTGGTTATCTT GCTTTATAAATTATGCCTCTAAACAATCAAATCTATTTTTGAAATAGACTGAATGATGTCAAGAAATATACCTACTGCTATCCGTATGTG GTGGATTAGAAATGTGTTAAATCTGCAAAAGGTATAAAGATGTCAGTTTAATTTCTTTGATAATTTAACCTATGTTGTATGTGAATTATT TATTATAAACTTAGCACGATTCTGTGACTGTTTTTCTCTGTTTCACGTTCGTTGAGTGTAAGCAATGAAAATGTCCCAAATAAGTTTTTT AAGTTTTACTTTAATAAGATTAATTTCAGTAAACATTCTAGTTGTTCAGTGTAACCTTTTTATCTTGATGCATTGTAAGTAAAATGAATC ATTTACTCTTGAAATGCCAGTCATTGACTGATGTAGATAATTTAGGATTTTCATATAAAAATAGCTGTTTAGGAAGGTGAAATACATTCA CTGTCTCTGTTGGTGGTACATCTTGTTGAATTCAATATTAGAAAGTATTTCTTTTTGGGGTAATATAACTTAGAATTAAATCCCTGTTTC TCTATGTAGTCTGGCAGTATAAATATAAATATTTACCATATAATCTTGGAATAAGTATTAGTTAATGTTACCAAAATCTGTATTAAATAA TGTTTTCAAATGCTAAATATGGTCGTTACTATTTTCAGTTTTAAAAATTTTATAGTATCAAATTGTTTCTAACCAAAAATTTCCTTTTAC TTCTAGAGATGCTTTATGTTTTTGATTATTAAATAGTCACTAGTATTGCTAATTTTTGAAACAAATACACAAAATTTATCATATGTAGAA ATAAGAAAATATTGTTTAGGTTAATTATTTTTTACCTATCCAGAGTCATTCCTTACATTTCAGTTTCATGTTTCATTCCTCACATTTTAG TTTCATGTTTTAGTTTGATTCTATGTTTTTAGACTGATAGCAAATGATTACTTGATACATGTAAGTTCAGCGTTATATGTTGAGGCAGTT ATATAATTAAATAAGGAACACTTAGGGCATTGATCTTGTACACTTAAAATCTGACAAATGACAAAATGTGAATTAAGCATAAATAGTCAT GGCAGGAGGGCTTTTGTTTATTTCTCTTGTTTTTGTTTAACTGTATTTTTAATTTTGTCTGGTGGTAAGAGGGAGGTAATTATTGTATGG AAAGAAGTTAGATCTTTCAGATAGATAAATAGGCTTCAGGTTTTGAAGTCTGCTCTGTGTAGTTGAGCAGTCATGGTTAACTTTACTTAG AAAATTAGTCTGACAAGCTTTGCACTTCGGTCACATAAGTGCCCATGTACAAAGTTGGCTTACTGGATCTGCATATTCAAAATATGCAAC TACAAATTTATCCTCTGAGAAATCTTCTGAGGAGTCTAATGTATTCCAAATGACTTAATATTCTCAGACAAATGCTTTAAAATACTTGGA TTATCTCAAGATTTTTGAAGCTAATAAAGTAAATAGAAACACAGGCCATTTTAAATGGTAAATTCTAGTTACATAAATATAATCTTAAAG TATGTTTGTATCTGTAACAGTGTTAGACCAGATTTGGTTTCTACCTCCCCAATGTTATAAATGTTCACTTTTGTTTTTATAAACCATATT ACTGTAAGATCAATAGAACTTTGCCTAGTTAAGTGAATGGAACCAATTAAACAACTAGTAGCTTTTTATAATGTTAGTGTGAACTTGAAA AATTGTTTTTGGTGGAATTTTTGTCTGTGGTTAGAACATTTTCATAAAACAGATAAAGAATGTGTAATACTCTTAATTTTTTTTTTTTTT TTTTTTTTTTTTTTGCTTTCTGCCTTCTAAAGTGCAACAGTATATATCTTGTAGAACTGTGGGAGGAGAGAAGATAATTTTTCTACCTTA CTCCATATTCTTACTTCAAACTATTTTGAATAGAGGTTCACTGAGCCATTGCTGATAGACTGTGCATAGCTACTAGCTGTCACACTATTG TAGGTTTTTTGGAGAGATTCATAGGGAAGTGAATGTAACCAGGAATAAAGGCTCTCACTTTAGCTCTGGGACTATGCAGTGGATCTTGGG AACAAAATAAGATATCTAATCTATTTTCCCCATTCTGGCTAGATTTTGGTTGTTGTGATGCTCCTACTTCCTGTATAGGTTTTTGGGATC ATGGTGCAGGCTAGTAATAGGATTCAGAATTGCTTCCCTTTTATATCGACCATGTAAGGGATTCTAAAGGAGGGTAAATCTCAAAGTGCT CTGAAATCATCCCTCTAAAATCTGTCCTGTGGTGTGCTAAGATGTCTGTTGCCTTTTTATGTTAAGCTAAGGAACTTGAATGCCTTACCT AATAACTCAACTAGTAGTAAGCTCATTTTGTAAATATGAAAATGGCTGTAAGAAGTGGCATTCATGTATATTCAATGTTAGTCAATAGAC CATAGTGGCCTGGATGCTTTAACAAGCCAAATTCCGCAATTTTTTTTCCTTTTTTCCCCTTCATACTTGTATGATCTCACCTGACCAGTG ATTTCTTTTCCTCCTAACCCCATGCTACCACCATTTTCTGGAAATCAAAGAGATGTGGTAGTAAATCATACAGTACACACGATCATCTGA GATCAATATGAGCACAAAACTCATCAAGTAGGTCTGCCTGGAATGTATATAAAAAATGTAAATAAAAATTTGTAAATTAGTGTGAACTGT ATCTTGCATATGAGACTGTGTATTGTTTTGCATTCTCTTCCCTTTTGTAGAAATTTTTCTGTAAGGAAATGATTCAGCTTGTTGGTTTTA GAGTAAAAATAGCCAACAGTTGTGGCTACACAGTGAGATCACAGGAACTGGAAATAGGGTTTGTCGGCTTTGGTTAATGTCAGTACTCAT TTATTTAGCCTCTCAGTGCTTAATAAGACTTTTCTTTATTTTTTAGTTAGCCGTTAGGTTTTGTGAGGTTAGATTCCTGGAAGCAGTGAA TTTATACACTGTTATATTAATAGAGCTCCGTTCTTTGAGTCATGATTCCAAGCTAAAGGAAATTAAAAATGTAATTTAATAATTTCCTAT TTTTAGGGTTGTTAATTTTTTTCTACAAAAAAACCTTGAAATTTTAGATATCCCAATGTGAATCTAATTTCCATATATACAGAAATTAGA CAAATAATAAGTCTTTAGTTCAACTTAAGCATATCTCAAATGACTTCTCTAAATTTAAAGTTGATCATGATAGGATCATAAAAGACAGAA AAGACTTAAGTAATCTTGTAATGACAATTATTTCCATTTTTGCTGAACTAAAAATATTTAACTTCATAAATATGTTACTACAGCTTCCAG ATTTAAAGAAAAAAAGTTTCCCCCACTCTCAATTAAAAGTTAGAACCCTCCACTTTTAAAATTATACAAATATTTCTTTTTTACATTACA CAGAAGCCTTCTGTACCATTTTACGAATTTCTGTCTTCATAATATAAGTGAAAATACTGTCATTTCAATTTTCTGCTTTAAATTGTTTTT AATAAGCATTCCAAAGTGATACAGACTTAAGCTTTTAATCAATCAGTCATTCAGTTGATAGACAAAGTTAGCGATGCTTTATGCTAGGAA ACTTGTTGACAGTAACCTGTGCGACTTTATGCAGAAGACAAATGCTAGTAATTATTATGCACAGAGGAAAAATCATTTTAAGTATGTGGT AAAGCAGCTTCATCTTTCAAAATTGATTTGCTCTGGTTTTTCTTTAGTCCATTAGATTCCAGAATGTCCTTTTACTGGGAATTTAGTTAT GTATTAAGATAACCTGTTTTCAGTTCTTTTTGAAAAGAAGACATTATTTATATTGAACCACCTTATTTTAAAATTTTTAACTTTTATATA CCACTTGTGTGATTCCAGTGTCATGTCTTGGGTTTGATGTCGTTGGACAGAAAAGTGTATCAATTATTTTAAATGAATTTTTCCCCATGT TTGAGGCTTAGTCTGTAAATGTGTTGCTGTAACAGAAAATACTTGGGTATGCATTACTTGAATACTTGAAAACTGAAATTAATAAGATGT ATTACATAATGAATTAGATTTCTCTGAACAGTTTTTACACTGAAAATCTTCATTTCTGGATTGCAGTTTGAAATGGAATGAAGACCTGAA TTATTTGGGTAGAAAAAATTATGATAGTGCTTATAAGAACTGTAAACTGTTTTAAACTATTTTGTGTTTGACGCATCAAACTTCAAGTTT TTTGTAAGTTTCTCTCCTGAAATTTTCTTTCTCTTCTATACTTTATGCACTTACTATACTACTGATGTAATAAAAGAGCAGGGTTAAAAA TATTGTATCTGTATTCATTGTGAATCCTGTAGCTTTTCTAGTTAACAAAAAATCGCTTTCTAAAATACTCTTAATCCCATTGTTTTGGTT AACATCTTACCCATTTGTTGTATTTCAAATGCCATTAATCATTTTAGTACAACACCTATGTTTATAAAAATTTGAAAACATTACATATTG TATTTAAAACTAATTAGTGAAGAGTAAGAAAAAAACTAGCCAACAGAATTGTAGGTGATGCATTAGTTAAATTTCAAAACTCATAATAAA GGAACTTTCAGAGATTGGTTGAAACCCAGTGGTATCCCTGTAAATTAGCTCCTGTGACTGGAAAAGACCCCAAAAAGGCAGTAGAGGAGA TTAGTGTTTACTTGCTGTGGTTGTGGTGTGCTGCTACTTAATTATAGGTAGTGACACACTGAAATTCTTATTTGTCCAATAATCTGAAGT AGTTTCCTATATTTATCTGTACTAAATTGACTATAAATTGAGTCTGCAAAGAGGAAACTTTTTGACTGTACTGTATTTAGGAGCCTTTGT ACAGCTTGGTCAAATTTCCATGATATGAAGTATTTGAGTTTTAAAATATACTGTTATTAAAAGGAAAAAGACATGGCCATTATTCCATGT GCTTAAATGATAATTTCCTTATTCAGTTTCAGAAGAAAAAGAATGAAATTGGGTAACTGTCATTGCGTTAGCTTTATGTTGAATTGGGAA ATTGTGGCATAAAGCTTAAATTCGTGTTTATCAAATGTGAACCATAGTAGTATAATGCTGCTTTGTATATAATGTAAGTGCTACAAATAG TCTCAGCACTGAAAATGTATTGATACCTCTTAAATGAATGCAACTTTTGATGTAGGTGTTTTGCTATGCCTCAGAAAATATCTGTCTGAG AATTTGTTAATCTGTTTGATAATGAAGATACTTCCTGTTTTCTTGTTTCATATTTTCATGTTCAAAATTTAAGTTTTACATTTTTACTAC TGTTAATTTAAATAAAATTTGTTCTGTGGATAAAATGAGGTTGGCAGTGAAGAAAATTAAAAACAGCCTCATTCATGTAACTGGTTAAGT AAAAATACATTTTCACTATGTGTTCATAAACTTTTAATGAAGCTGTTTGTCTTTCAGTTCAAATATAAGTGATGTTTAGGCTTTATTTCT GTTAATAAGGCTTTTTACCATTGATTAAATGAAGGAATGTATCTTTTTGAAGAGATTTATATTCTGTAAATAAAAATTCGTTGTAACAAT >43430_43430_3_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000311936_ETNK1_chr12_22796696_ENST00000266517_length(amino acids)=351AA_BP=40 MLKMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIELFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQA HGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIP SSQILQEEMTWMKEILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQSQWLR -------------------------------------------------------------- >43430_43430_4_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000311936_ETNK1_chr12_22796696_ENST00000335148_length(transcript)=940nt_BP=303nt TCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCC CCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGA GGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAAT CATTTTGTGGACGAATATGATCCAACAATAGAGCTCTTCACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACACCATG GAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGACTGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGTTGCAG GCTCATGGGTGTGCACCACAACTCTACTGTACCTTCAATAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAAAGCAT GTCTGCAACCCAGCCATTTTCAGTTTATCATCGTTGACTCTTTGCAAAGGAAAAACTACAAGATGTTTTGGATTAACCGGCTGCAGAGGG TCAAGGCTTCTGCTTAGTTTTTTCTAGTTAGTGTTTGAGTTGAAGTGTTATACATTTCTTACTGCCGATTGCTTATTACTTAATTGTTCA TGTTTTCAGAGTTCTTGCCTATTAAAATTTTATTAATTTGGTTAACAATTCTTTGTTCTTTACGTTGTTCATTATTTAATTTAATATATT ATGTTTTCTATAAAGAATAATGTCATATATGCTTGATCATTTTTCCAAAATTGCCAGCTTTAAAAATTCTCTTTCTGCTCTTGAAAACTC >43430_43430_4_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000311936_ETNK1_chr12_22796696_ENST00000335148_length(amino acids)=157AA_BP=40 MLKMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIELFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQA -------------------------------------------------------------- >43430_43430_5_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000557334_ETNK1_chr12_22796696_ENST00000266517_length(transcript)=6955nt_BP=308nt GATTTTCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCC CGGCCCCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGG AGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTC AGAATCATTTTGTGGACGAATATGATCCAACAATAGAGCTCTTCACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACA CCATGGAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGACTGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGT TGCAGGCTCATGGGTGTGCACCACAACTCTACTGTACCTTCAATAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAA AGCATGTCTGCAACCCAGCCATTTTCAGGCTAATAGCTCGTCAGCTTGCTAAAATCCATGCTATTCATGCACACAATGGCTGGATCCCCA AATCTAATCTTTGGCTAAAGATGGGAAAGTATTTCTCTCTCATTCCCACAGGATTTGCAGATGAAGACATTAATAAAAGGTTCCTAAGTG ATATCCCAAGCTCTCAGATTCTCCAGGAAGAGATGACTTGGATGAAGGAGATTCTTTCCAACCTGGGCTCACCTGTTGTGCTTTGCCATA ATGACCTATTGTGTAAGAATATAATCTACAATGAGAAACAAGGTGATGTACAGTTCATTGATTATGAATATTCTGGATACAACTACCTGG CATATGATATTGGAAATCATTTCAATGAATTTGCAGGTGTGAGTGATGTAGACTATAGTCTGTATCCAGATAGAGAACTACAGAGTCAGT GGCTGCGTGCTTACCTTGAAGCCTACAAAGAATTTAAGGGCTTTGGGACTGAAGTTACTGAAAAGGAGGTAGAAATACTCTTCATTCAAG TCAATCAGTTTGCATTGGCTTCTCATTTCTTTTGGGGATTGTGGGCTTTGATTCAAGCCAAATACTCCACTATTGAGTTTGATTTCCTTG GGTATGCAATTGTTCGTTTTAACCAGTACTTTAAAATGAAGCCTGAGGTTACTGCATTAAAAGTGCCTGAGTAAAGAAGAGATTTAATTA TTCTCCAGTAGCTGAGCAATGCTTGTGAATCTTTTCTTAAGAAATCCCAAAAAGCCAATATTAGTTAAAATTCTGTTGTTTAATTTGGTT ATCTTGCTTTATAAATTATGCCTCTAAACAATCAAATCTATTTTTGAAATAGACTGAATGATGTCAAGAAATATACCTACTGCTATCCGT ATGTGGTGGATTAGAAATGTGTTAAATCTGCAAAAGGTATAAAGATGTCAGTTTAATTTCTTTGATAATTTAACCTATGTTGTATGTGAA TTATTTATTATAAACTTAGCACGATTCTGTGACTGTTTTTCTCTGTTTCACGTTCGTTGAGTGTAAGCAATGAAAATGTCCCAAATAAGT TTTTTAAGTTTTACTTTAATAAGATTAATTTCAGTAAACATTCTAGTTGTTCAGTGTAACCTTTTTATCTTGATGCATTGTAAGTAAAAT GAATCATTTACTCTTGAAATGCCAGTCATTGACTGATGTAGATAATTTAGGATTTTCATATAAAAATAGCTGTTTAGGAAGGTGAAATAC ATTCACTGTCTCTGTTGGTGGTACATCTTGTTGAATTCAATATTAGAAAGTATTTCTTTTTGGGGTAATATAACTTAGAATTAAATCCCT GTTTCTCTATGTAGTCTGGCAGTATAAATATAAATATTTACCATATAATCTTGGAATAAGTATTAGTTAATGTTACCAAAATCTGTATTA AATAATGTTTTCAAATGCTAAATATGGTCGTTACTATTTTCAGTTTTAAAAATTTTATAGTATCAAATTGTTTCTAACCAAAAATTTCCT TTTACTTCTAGAGATGCTTTATGTTTTTGATTATTAAATAGTCACTAGTATTGCTAATTTTTGAAACAAATACACAAAATTTATCATATG TAGAAATAAGAAAATATTGTTTAGGTTAATTATTTTTTACCTATCCAGAGTCATTCCTTACATTTCAGTTTCATGTTTCATTCCTCACAT TTTAGTTTCATGTTTTAGTTTGATTCTATGTTTTTAGACTGATAGCAAATGATTACTTGATACATGTAAGTTCAGCGTTATATGTTGAGG CAGTTATATAATTAAATAAGGAACACTTAGGGCATTGATCTTGTACACTTAAAATCTGACAAATGACAAAATGTGAATTAAGCATAAATA GTCATGGCAGGAGGGCTTTTGTTTATTTCTCTTGTTTTTGTTTAACTGTATTTTTAATTTTGTCTGGTGGTAAGAGGGAGGTAATTATTG TATGGAAAGAAGTTAGATCTTTCAGATAGATAAATAGGCTTCAGGTTTTGAAGTCTGCTCTGTGTAGTTGAGCAGTCATGGTTAACTTTA CTTAGAAAATTAGTCTGACAAGCTTTGCACTTCGGTCACATAAGTGCCCATGTACAAAGTTGGCTTACTGGATCTGCATATTCAAAATAT GCAACTACAAATTTATCCTCTGAGAAATCTTCTGAGGAGTCTAATGTATTCCAAATGACTTAATATTCTCAGACAAATGCTTTAAAATAC TTGGATTATCTCAAGATTTTTGAAGCTAATAAAGTAAATAGAAACACAGGCCATTTTAAATGGTAAATTCTAGTTACATAAATATAATCT TAAAGTATGTTTGTATCTGTAACAGTGTTAGACCAGATTTGGTTTCTACCTCCCCAATGTTATAAATGTTCACTTTTGTTTTTATAAACC ATATTACTGTAAGATCAATAGAACTTTGCCTAGTTAAGTGAATGGAACCAATTAAACAACTAGTAGCTTTTTATAATGTTAGTGTGAACT TGAAAAATTGTTTTTGGTGGAATTTTTGTCTGTGGTTAGAACATTTTCATAAAACAGATAAAGAATGTGTAATACTCTTAATTTTTTTTT TTTTTTTTTTTTTTTTTTTGCTTTCTGCCTTCTAAAGTGCAACAGTATATATCTTGTAGAACTGTGGGAGGAGAGAAGATAATTTTTCTA CCTTACTCCATATTCTTACTTCAAACTATTTTGAATAGAGGTTCACTGAGCCATTGCTGATAGACTGTGCATAGCTACTAGCTGTCACAC TATTGTAGGTTTTTTGGAGAGATTCATAGGGAAGTGAATGTAACCAGGAATAAAGGCTCTCACTTTAGCTCTGGGACTATGCAGTGGATC TTGGGAACAAAATAAGATATCTAATCTATTTTCCCCATTCTGGCTAGATTTTGGTTGTTGTGATGCTCCTACTTCCTGTATAGGTTTTTG GGATCATGGTGCAGGCTAGTAATAGGATTCAGAATTGCTTCCCTTTTATATCGACCATGTAAGGGATTCTAAAGGAGGGTAAATCTCAAA GTGCTCTGAAATCATCCCTCTAAAATCTGTCCTGTGGTGTGCTAAGATGTCTGTTGCCTTTTTATGTTAAGCTAAGGAACTTGAATGCCT TACCTAATAACTCAACTAGTAGTAAGCTCATTTTGTAAATATGAAAATGGCTGTAAGAAGTGGCATTCATGTATATTCAATGTTAGTCAA TAGACCATAGTGGCCTGGATGCTTTAACAAGCCAAATTCCGCAATTTTTTTTCCTTTTTTCCCCTTCATACTTGTATGATCTCACCTGAC CAGTGATTTCTTTTCCTCCTAACCCCATGCTACCACCATTTTCTGGAAATCAAAGAGATGTGGTAGTAAATCATACAGTACACACGATCA TCTGAGATCAATATGAGCACAAAACTCATCAAGTAGGTCTGCCTGGAATGTATATAAAAAATGTAAATAAAAATTTGTAAATTAGTGTGA ACTGTATCTTGCATATGAGACTGTGTATTGTTTTGCATTCTCTTCCCTTTTGTAGAAATTTTTCTGTAAGGAAATGATTCAGCTTGTTGG TTTTAGAGTAAAAATAGCCAACAGTTGTGGCTACACAGTGAGATCACAGGAACTGGAAATAGGGTTTGTCGGCTTTGGTTAATGTCAGTA CTCATTTATTTAGCCTCTCAGTGCTTAATAAGACTTTTCTTTATTTTTTAGTTAGCCGTTAGGTTTTGTGAGGTTAGATTCCTGGAAGCA GTGAATTTATACACTGTTATATTAATAGAGCTCCGTTCTTTGAGTCATGATTCCAAGCTAAAGGAAATTAAAAATGTAATTTAATAATTT CCTATTTTTAGGGTTGTTAATTTTTTTCTACAAAAAAACCTTGAAATTTTAGATATCCCAATGTGAATCTAATTTCCATATATACAGAAA TTAGACAAATAATAAGTCTTTAGTTCAACTTAAGCATATCTCAAATGACTTCTCTAAATTTAAAGTTGATCATGATAGGATCATAAAAGA CAGAAAAGACTTAAGTAATCTTGTAATGACAATTATTTCCATTTTTGCTGAACTAAAAATATTTAACTTCATAAATATGTTACTACAGCT TCCAGATTTAAAGAAAAAAAGTTTCCCCCACTCTCAATTAAAAGTTAGAACCCTCCACTTTTAAAATTATACAAATATTTCTTTTTTACA TTACACAGAAGCCTTCTGTACCATTTTACGAATTTCTGTCTTCATAATATAAGTGAAAATACTGTCATTTCAATTTTCTGCTTTAAATTG TTTTTAATAAGCATTCCAAAGTGATACAGACTTAAGCTTTTAATCAATCAGTCATTCAGTTGATAGACAAAGTTAGCGATGCTTTATGCT AGGAAACTTGTTGACAGTAACCTGTGCGACTTTATGCAGAAGACAAATGCTAGTAATTATTATGCACAGAGGAAAAATCATTTTAAGTAT GTGGTAAAGCAGCTTCATCTTTCAAAATTGATTTGCTCTGGTTTTTCTTTAGTCCATTAGATTCCAGAATGTCCTTTTACTGGGAATTTA GTTATGTATTAAGATAACCTGTTTTCAGTTCTTTTTGAAAAGAAGACATTATTTATATTGAACCACCTTATTTTAAAATTTTTAACTTTT ATATACCACTTGTGTGATTCCAGTGTCATGTCTTGGGTTTGATGTCGTTGGACAGAAAAGTGTATCAATTATTTTAAATGAATTTTTCCC CATGTTTGAGGCTTAGTCTGTAAATGTGTTGCTGTAACAGAAAATACTTGGGTATGCATTACTTGAATACTTGAAAACTGAAATTAATAA GATGTATTACATAATGAATTAGATTTCTCTGAACAGTTTTTACACTGAAAATCTTCATTTCTGGATTGCAGTTTGAAATGGAATGAAGAC CTGAATTATTTGGGTAGAAAAAATTATGATAGTGCTTATAAGAACTGTAAACTGTTTTAAACTATTTTGTGTTTGACGCATCAAACTTCA AGTTTTTTGTAAGTTTCTCTCCTGAAATTTTCTTTCTCTTCTATACTTTATGCACTTACTATACTACTGATGTAATAAAAGAGCAGGGTT AAAAATATTGTATCTGTATTCATTGTGAATCCTGTAGCTTTTCTAGTTAACAAAAAATCGCTTTCTAAAATACTCTTAATCCCATTGTTT TGGTTAACATCTTACCCATTTGTTGTATTTCAAATGCCATTAATCATTTTAGTACAACACCTATGTTTATAAAAATTTGAAAACATTACA TATTGTATTTAAAACTAATTAGTGAAGAGTAAGAAAAAAACTAGCCAACAGAATTGTAGGTGATGCATTAGTTAAATTTCAAAACTCATA ATAAAGGAACTTTCAGAGATTGGTTGAAACCCAGTGGTATCCCTGTAAATTAGCTCCTGTGACTGGAAAAGACCCCAAAAAGGCAGTAGA GGAGATTAGTGTTTACTTGCTGTGGTTGTGGTGTGCTGCTACTTAATTATAGGTAGTGACACACTGAAATTCTTATTTGTCCAATAATCT GAAGTAGTTTCCTATATTTATCTGTACTAAATTGACTATAAATTGAGTCTGCAAAGAGGAAACTTTTTGACTGTACTGTATTTAGGAGCC TTTGTACAGCTTGGTCAAATTTCCATGATATGAAGTATTTGAGTTTTAAAATATACTGTTATTAAAAGGAAAAAGACATGGCCATTATTC CATGTGCTTAAATGATAATTTCCTTATTCAGTTTCAGAAGAAAAAGAATGAAATTGGGTAACTGTCATTGCGTTAGCTTTATGTTGAATT GGGAAATTGTGGCATAAAGCTTAAATTCGTGTTTATCAAATGTGAACCATAGTAGTATAATGCTGCTTTGTATATAATGTAAGTGCTACA AATAGTCTCAGCACTGAAAATGTATTGATACCTCTTAAATGAATGCAACTTTTGATGTAGGTGTTTTGCTATGCCTCAGAAAATATCTGT CTGAGAATTTGTTAATCTGTTTGATAATGAAGATACTTCCTGTTTTCTTGTTTCATATTTTCATGTTCAAAATTTAAGTTTTACATTTTT ACTACTGTTAATTTAAATAAAATTTGTTCTGTGGATAAAATGAGGTTGGCAGTGAAGAAAATTAAAAACAGCCTCATTCATGTAACTGGT TAAGTAAAAATACATTTTCACTATGTGTTCATAAACTTTTAATGAAGCTGTTTGTCTTTCAGTTCAAATATAAGTGATGTTTAGGCTTTA TTTCTGTTAATAAGGCTTTTTACCATTGATTAAATGAAGGAATGTATCTTTTTGAAGAGATTTATATTCTGTAAATAAAAATTCGTTGTA >43430_43430_5_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000557334_ETNK1_chr12_22796696_ENST00000266517_length(amino acids)=351AA_BP=40 MLKMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIELFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQA HGCAPQLYCTFNNGLCYEFIQGEALDPKHVCNPAIFRLIARQLAKIHAIHAHNGWIPKSNLWLKMGKYFSLIPTGFADEDINKRFLSDIP SSQILQEEMTWMKEILSNLGSPVVLCHNDLLCKNIIYNEKQGDVQFIDYEYSGYNYLAYDIGNHFNEFAGVSDVDYSLYPDRELQSQWLR -------------------------------------------------------------- >43430_43430_6_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000557334_ETNK1_chr12_22796696_ENST00000335148_length(transcript)=945nt_BP=308nt GATTTTCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCC CGGCCCCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGG AGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTC AGAATCATTTTGTGGACGAATATGATCCAACAATAGAGCTCTTCACAGATGGAATCACAAATAAACTTATTGGCTGTTACGTGGGAAACA CCATGGAGGATGTAGTCCTGGTGAGAATTTATGGCAATAAGACTGAGTTATTAGTCGATCGAGATGAGGAAGTAAAGAGTTTTCGAGTGT TGCAGGCTCATGGGTGTGCACCACAACTCTACTGTACCTTCAATAATGGACTATGCTATGAATTTATACAAGGAGAAGCACTGGATCCAA AGCATGTCTGCAACCCAGCCATTTTCAGTTTATCATCGTTGACTCTTTGCAAAGGAAAAACTACAAGATGTTTTGGATTAACCGGCTGCA GAGGGTCAAGGCTTCTGCTTAGTTTTTTCTAGTTAGTGTTTGAGTTGAAGTGTTATACATTTCTTACTGCCGATTGCTTATTACTTAATT GTTCATGTTTTCAGAGTTCTTGCCTATTAAAATTTTATTAATTTGGTTAACAATTCTTTGTTCTTTACGTTGTTCATTATTTAATTTAAT ATATTATGTTTTCTATAAAGAATAATGTCATATATGCTTGATCATTTTTCCAAAATTGCCAGCTTTAAAAATTCTCTTTCTGCTCTTGAA >43430_43430_6_KRAS-ETNK1_KRAS_chr12_25398207_ENST00000557334_ETNK1_chr12_22796696_ENST00000335148_length(amino acids)=157AA_BP=40 MLKMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIELFTDGITNKLIGCYVGNTMEDVVLVRIYGNKTELLVDRDEEVKSFRVLQA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KRAS-ETNK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KRAS-ETNK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KRAS-ETNK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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