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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KRAS-IFLTD1 (FusionGDB2 ID:43431)

Fusion Gene Summary for KRAS-IFLTD1

Fusion gene summary

Fusion gene information	Fusion gene name: KRAS-IFLTD1
	Fusion gene ID: 43431
		Hgene	Tgene
	Gene symbol	KRAS	IFLTD1
	Gene ID	3845	160492
	Gene name	KRAS proto-oncogene, GTPase	lamin tail domain containing 1
	Synonyms	'C-K-RAS\|C-K-RAS\|CFC2\|K-RAS2A\|K-RAS2B\|K-RAS4A\|K-RAS4B\|K-Ras\|K-Ras 2\|KI-RAS\|KRAS1\|KRAS2\|NS\|NS3\|OES\|RALD\|RASK2\|c-Ki-ras\|c-Ki-ras2	IFLTD1\|LMNARS1\|PAS1C1
	Cytomap	12p12.1	12p12.1
	Type of gene	protein-coding	protein-coding
	Description	GTPase KRasK-ras p21 proteinKirsten rat sarcoma viral oncogene homologKirsten rat sarcoma viral proto-oncogenePR310 c-K-ras oncogenec-Kirsten-ras proteincellular c-Ki-ras2 proto-oncogenecellular transforming proto-oncogeneoncogene KRAS2transformi	lamin tail domain-containing protein 1intermediate filament tail domain containing 1intermediate filament tail domain-containing protein 1
	Modification date	20200329	20200313
	UniProtAcc	P01116	.
	Ensembl transtripts involved in fusion gene	ENST00000256078, ENST00000311936, ENST00000556131, ENST00000557334,	ENST00000282881, ENST00000539744, ENST00000413632, ENST00000445693, ENST00000458174,
Fusion gene scores	* DoF score	6 X 2 X 5=60	8 X 5 X 5=200
	# samples	6	8
	** MAII score	log2(6/60*10)=0	log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KRAS [Title/Abstract] AND IFLTD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KRAS(25398208)-IFLTD1(25656734), # samples:2
Anticipated loss of major functional domain due to fusion event.	KRAS-IFLTD1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KRAS-IFLTD1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across KRAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IFLTD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-1511-01A	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-

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Fusion Gene ORF analysis for KRAS-IFLTD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000256078	ENST00000282881	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000256078	ENST00000539744	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000311936	ENST00000282881	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000311936	ENST00000539744	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000556131	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000556131	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000556131	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000557334	ENST00000282881	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
Frame-shift	ENST00000557334	ENST00000539744	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000256078	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000256078	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000256078	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000311936	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000311936	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000311936	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000556131	ENST00000282881	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000556131	ENST00000539744	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000557334	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000557334	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-
In-frame	ENST00000557334	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000311936	KRAS	chr12	25398208	-	ENST00000458174	IFLTD1	chr12	25656734	-	546	303	257	0	86
ENST00000311936	KRAS	chr12	25398208	-	ENST00000445693	IFLTD1	chr12	25656734	-	648	303	379	645	89
ENST00000311936	KRAS	chr12	25398208	-	ENST00000413632	IFLTD1	chr12	25656734	-	511	303	257	0	86
ENST00000557334	KRAS	chr12	25398208	-	ENST00000458174	IFLTD1	chr12	25656734	-	551	308	262	2	87
ENST00000557334	KRAS	chr12	25398208	-	ENST00000445693	IFLTD1	chr12	25656734	-	653	308	384	650	89
ENST00000557334	KRAS	chr12	25398208	-	ENST00000413632	IFLTD1	chr12	25656734	-	516	308	262	2	87
ENST00000256078	KRAS	chr12	25398208	-	ENST00000458174	IFLTD1	chr12	25656734	-	418	175	55	240	61
ENST00000256078	KRAS	chr12	25398208	-	ENST00000445693	IFLTD1	chr12	25656734	-	520	175	251	517	89
ENST00000256078	KRAS	chr12	25398208	-	ENST00000413632	IFLTD1	chr12	25656734	-	383	175	55	297	80
ENST00000556131	KRAS	chr12	25398208	-	ENST00000282881	IFLTD1	chr12	25656734	-	730	288	336	1	112
ENST00000556131	KRAS	chr12	25398208	-	ENST00000539744	IFLTD1	chr12	25656734	-	702	288	102	353	83

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000311936	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.050670855	0.9493291
ENST00000311936	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.08312076	0.91687924
ENST00000311936	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.06515388	0.9348461
ENST00000557334	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.049300134	0.9506999
ENST00000557334	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.06323786	0.9367622
ENST00000557334	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.05455292	0.9454471
ENST00000256078	ENST00000458174	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.16573134	0.8342686
ENST00000256078	ENST00000445693	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.13299918	0.86700076
ENST00000256078	ENST00000413632	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.09296701	0.90703297
ENST00000556131	ENST00000282881	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.09514588	0.9048542
ENST00000556131	ENST00000539744	KRAS	chr12	25398208	-	IFLTD1	chr12	25656734	-	0.09331295	0.9066871

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Fusion Genomic Features for KRAS-IFLTD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KRAS-IFLTD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:25398208/chr12:25656734)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KRAS P01116	.
FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306). {ECO:0000269\|PubMed:20949621, ECO:0000269\|PubMed:22711838, ECO:0000269\|PubMed:23698361, ECO:0000269\|PubMed:24623306, ECO:0000305}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000256078

32_40

333.3333333333333

Motif

Note=Effector region

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000311936

32_40

189.0

Motif

Note=Effector region

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000256078

10_18

333.3333333333333

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000256078

29_35

333.3333333333333

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000311936

10_18

189.0

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000311936

29_35

189.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000256078

116_119

333.3333333333333

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000256078

59_60

333.3333333333333

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000311936

116_119

189.0

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000311936

59_60

189.0

Nucleotide binding

GTP

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000256078

166_185

333.3333333333333

Region

Note=Hypervariable region

Hgene

KRAS

chr12:25398208

chr12:25656734

ENST00000311936

166_185

189.0

Region

Note=Hypervariable region

Tgene

IFLTD1

chr12:25398208

chr12:25656734

ENST00000282881

136_254

375

404.0

Domain

LTD

Tgene

IFLTD1

chr12:25398208

chr12:25656734

ENST00000413632

136_254

356

328.6666666666667

Domain

LTD

Tgene

IFLTD1

chr12:25398208

chr12:25656734

ENST00000445693

136_254

312

360.3333333333333

Domain

LTD

Tgene

IFLTD1

chr12:25398208

chr12:25656734

ENST00000458174

136_254

396

379.6666666666667

Domain

LTD

Tgene

IFLTD1

chr12:25398208

chr12:25656734

ENST00000539744

136_254

278

327.0

Domain

LTD

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Fusion Gene Sequence for KRAS-IFLTD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43431_43431_1_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000256078_IFLTD1_chr12_25656734_ENST00000413632_length(transcript)=383nt_BP=175nt
CTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGT
TGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAATATGATCCAACAATAGAGGGTCT
AAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCTTTAAAGCTTTACCTTTATGGTGTCATGGTCCAGTTGTA
TGGAAGAGTAAAAAGACCTGCAATCTAGGCTCCCTGCCATGCTGGCCAAAGACATTCCACAACTTAAAGAAAATCAAATGCCTGAGCAAA

>43431_43431_1_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000256078_IFLTD1_chr12_25656734_ENST00000413632_length(amino acids)=80AA_BP=40

--------------------------------------------------------------
>43431_43431_2_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000256078_IFLTD1_chr12_25656734_ENST00000445693_length(transcript)=520nt_BP=175nt
CTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGT
TGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAATATGATCCAACAATAGAGGGTCT
AAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCTTTAAAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGT
GCAGTGGTGTGATCTCCACTAACTGCAGCCTCCGCCTCCCAGGTTCAAGTGAGTCTCCTGCGTCAGCCTCCCGAGTAGCTGGGATTACAG
GCATCCGCCACCCTGCATGGCTAATTTTTGTATTTTTAGTAGCAACGAGGTTTCACCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCT

>43431_43431_2_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000256078_IFLTD1_chr12_25656734_ENST00000445693_length(amino acids)=89AA_BP=

--------------------------------------------------------------
>43431_43431_3_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000256078_IFLTD1_chr12_25656734_ENST00000458174_length(transcript)=418nt_BP=175nt
CTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGT
TGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAATATGATCCAACAATAGAGGGTCT
AAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCTTTAAAGTAATCTAGTCCACCCTCAACCAGCTACTAGAA
AAGCAAAAGAGAACTCAAATCCCTGAGGCCTGCTCTGCAACCTCCCTGCTATTCCATGAGAGGGTGAAGACATCACATTTCTATATGGAA

>43431_43431_3_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000256078_IFLTD1_chr12_25656734_ENST00000458174_length(amino acids)=61AA_BP=40

--------------------------------------------------------------
>43431_43431_4_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000311936_IFLTD1_chr12_25656734_ENST00000413632_length(transcript)=511nt_BP=303nt
TCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCC
CCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGA
GGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAAT
CATTTTGTGGACGAATATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCT
TTAAAGCTTTACCTTTATGGTGTCATGGTCCAGTTGTATGGAAGAGTAAAAAGACCTGCAATCTAGGCTCCCTGCCATGCTGGCCAAAGA

>43431_43431_4_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000311936_IFLTD1_chr12_25656734_ENST00000413632_length(amino acids)=86AA_BP=

--------------------------------------------------------------
>43431_43431_5_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000311936_IFLTD1_chr12_25656734_ENST00000445693_length(transcript)=648nt_BP=303nt
TCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCC
CCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGA
GGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAAT
CATTTTGTGGACGAATATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCT
TTAAAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCCACTAACTGCAGCCTCCGCCTCCCAGGTTCAAGTGA
GTCTCCTGCGTCAGCCTCCCGAGTAGCTGGGATTACAGGCATCCGCCACCCTGCATGGCTAATTTTTGTATTTTTAGTAGCAACGAGGTT
TCACCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACACGCATGAG

>43431_43431_5_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000311936_IFLTD1_chr12_25656734_ENST00000445693_length(amino acids)=89AA_BP=

--------------------------------------------------------------
>43431_43431_6_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000311936_IFLTD1_chr12_25656734_ENST00000458174_length(transcript)=546nt_BP=303nt
TCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCC
CCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGGAGAGA
GGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAAT
CATTTTGTGGACGAATATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCT
TTAAAGTAATCTAGTCCACCCTCAACCAGCTACTAGAAAAGCAAAAGAGAACTCAAATCCCTGAGGCCTGCTCTGCAACCTCCCTGCTAT
TCCATGAGAGGGTGAAGACATCACATTTCTATATGGAAAAAGGATCCAAAATTTGTATTGCTGTAGAATTGGTGAATTATAGATGCTTGA

>43431_43431_6_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000311936_IFLTD1_chr12_25656734_ENST00000458174_length(amino acids)=86AA_BP=

--------------------------------------------------------------
>43431_43431_7_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000556131_IFLTD1_chr12_25656734_ENST00000282881_length(transcript)=730nt_BP=288nt
CTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCCCC
CGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGCCTGCTGAAAATG
ACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAA
TATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCTTTAAAGTAATCTAGT
CCACCCTCAACCAGCTACTAGAAAAGCAAAAGAGAACTCAAATCCCTGAGGCCTGCTCTGCAACCTCCCTGCTATTCCATGAGAGGGTGA
AGACATCACATTTCTATATGGAAAAAGGATCCAAAATTTGTATTGCTGTAGAATTGGTGAATTATAGATGCTTGATGAAATCACAAGTCC
TACCACTCCTGCCTTCCAAATCCCTGCAGAAAACAAGCAGATGGTTAGTATTATTCAATGGATAAAATTGCTATTTGCCTTAGATTTCTC
TTTTTGTAAACAAAGTTATTTTGGGTACAGAACTCACAAAAGAAGAGCACGTGCAATTGTTTAACCATTTTACATTGACTGATAAATCTC

>43431_43431_7_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000556131_IFLTD1_chr12_25656734_ENST00000282881_length(amino acids)=112AA_BP=1
MTAYCFCDSDVFFFLDPLLLDHIRPQNDSELAVSSRHSCLRHQLQLPQVYIQSFSAGLGAAEPLAPPPPSVPAPRSLPVRNGGGREYWPS

--------------------------------------------------------------
>43431_43431_8_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000556131_IFLTD1_chr12_25656734_ENST00000539744_length(transcript)=702nt_BP=288nt
CTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCCCGGCCCC
CGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGCCTGCTGAAAATG
ACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTCAGAATCATTTTGTGGACGAA
TATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTCAACCTTTAAAGTAATCTAGT
CCACCCTCAACCAGCTACTAGAAAAGCAAAAGAGAACTCAAATCCCTGAGGCCTGCTCTGCAACCTCCCTGCTATTCCATGAGAGGGTGA
AGACATCACATTTCTATATGGAAAAAGGATCCAAAATTTGTATTGCTGTAGAATTGGTGAATTATAGATGCTTGATGAAATCACAAGTCC
TACCACTCCTGCCTTCCAAATCCCTGCAGAAAACAAGCAGATGGTTAGTATTATTCAATGGATAAAATTGCTATTTGCCTTAGATTTCTC

>43431_43431_8_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000556131_IFLTD1_chr12_25656734_ENST00000539744_length(amino acids)=83AA_BP=62

--------------------------------------------------------------
>43431_43431_9_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000557334_IFLTD1_chr12_25656734_ENST00000413632_length(transcript)=516nt_BP=308nt
GATTTTCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCC
CGGCCCCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGG
AGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTC
AGAATCATTTTGTGGACGAATATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTC
AACCTTTAAAGCTTTACCTTTATGGTGTCATGGTCCAGTTGTATGGAAGAGTAAAAAGACCTGCAATCTAGGCTCCCTGCCATGCTGGCC

>43431_43431_9_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000557334_IFLTD1_chr12_25656734_ENST00000413632_length(amino acids)=87AA_BP=

--------------------------------------------------------------
>43431_43431_10_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000557334_IFLTD1_chr12_25656734_ENST00000445693_length(transcript)=653nt_BP=308nt
GATTTTCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCC
CGGCCCCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGG
AGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTC
AGAATCATTTTGTGGACGAATATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTC
AACCTTTAAAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCCACTAACTGCAGCCTCCGCCTCCCAGGTTCA
AGTGAGTCTCCTGCGTCAGCCTCCCGAGTAGCTGGGATTACAGGCATCCGCCACCCTGCATGGCTAATTTTTGTATTTTTAGTAGCAACG
AGGTTTCACCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACACGC

>43431_43431_10_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000557334_IFLTD1_chr12_25656734_ENST00000445693_length(amino acids)=89AA_BP=

--------------------------------------------------------------
>43431_43431_11_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000557334_IFLTD1_chr12_25656734_ENST00000458174_length(transcript)=551nt_BP=308nt
GATTTTCCTAGGCGGCGGCCGCGGCGGCGGAGGCAGCAGCGGCGGCGGCAGTGGCGGCGGCGAAGGTGGCGGCGGCTCGGCCAGTACTCC
CGGCCCCCGCCATTTCGGACTGGGAGCGAGCGCGGCGCAGGCACTGAAGGCGGCGGCGGGGCCAGAGGCTCAGCGGCTCCCAGGTGCGGG
AGAGAGGCCTGCTGAAAATGACTGAATATAAACTTGTGGTAGTTGGAGCTGGTGGCGTAGGCAAGAGTGCCTTGACGATACAGCTAATTC
AGAATCATTTTGTGGACGAATATGATCCAACAATAGAGGGTCTAAGAAAAAGAAGACATCTGAGTCACAAAAGCAATAAGCAGTCAACTC
AACCTTTAAAGTAATCTAGTCCACCCTCAACCAGCTACTAGAAAAGCAAAAGAGAACTCAAATCCCTGAGGCCTGCTCTGCAACCTCCCT
GCTATTCCATGAGAGGGTGAAGACATCACATTTCTATATGGAAAAAGGATCCAAAATTTGTATTGCTGTAGAATTGGTGAATTATAGATG

>43431_43431_11_KRAS-IFLTD1_KRAS_chr12_25398208_ENST00000557334_IFLTD1_chr12_25656734_ENST00000458174_length(amino acids)=87AA_BP=

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KRAS-IFLTD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KRAS-IFLTD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KRAS-IFLTD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source