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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KREMEN1-ENTHD1 (FusionGDB2 ID:43448)

Fusion Gene Summary for KREMEN1-ENTHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: KREMEN1-ENTHD1
Fusion gene ID: 43448
HgeneTgene
Gene symbol

KREMEN1

ENTHD1

Gene ID

83999

150350

Gene namekringle containing transmembrane protein 1ENTH domain containing 1
SynonymsECTD13|KREMEN|KRM1CACNA1I|dJ370M22.3
Cytomap

22q12.1

22q13.1

Type of geneprotein-codingprotein-coding
Descriptionkremen protein 1dickkopf receptorkringle domain-containing transmembrane protein 1kringle-coding gene marking the eye and the nosekringle-containing protein marking the eye and the noseENTH domain-containing protein 1dJ370M22.3 (EPSIN 2B)epsin-2B
Modification date2020031320200313
UniProtAcc

Q96MU8

Q8IYW4

Ensembl transtripts involved in fusion geneENST00000327813, ENST00000400335, 
ENST00000400338, ENST00000407188, 
ENST00000479755, 		ENST00000490326, 
ENST00000325157, 
Fusion gene scores* DoF score9 X 8 X 7=5045 X 6 X 6=180
# samples 116
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KREMEN1 [Title/Abstract] AND ENTHD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKREMEN1(29494941)-ENTHD1(40231963), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KREMEN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ENTHD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-MP-A4SV-01AKREMEN1chr22

29494941

-ENTHD1chr22

40231963

-
ChimerDB4LUADTCGA-MP-A4SV-01AKREMEN1chr22

29494941

+ENTHD1chr22

40231963

-


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Fusion Gene ORF analysis for KREMEN1-ENTHD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000327813ENST00000490326KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
5CDS-intronENST00000400335ENST00000490326KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
5CDS-intronENST00000400338ENST00000490326KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
5CDS-intronENST00000407188ENST00000490326KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
In-frameENST00000327813ENST00000325157KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
In-frameENST00000400335ENST00000325157KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
In-frameENST00000400338ENST00000325157KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
In-frameENST00000407188ENST00000325157KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
intron-3CDSENST00000479755ENST00000325157KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-
intron-intronENST00000479755ENST00000490326KREMEN1chr22

29494941

+ENTHD1chr22

40231963

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400338KREMEN1chr2229494941+ENST00000325157ENTHD1chr2240231963-2272405531636527
ENST00000400335KREMEN1chr2229494941+ENST00000325157ENTHD1chr2240231963-2272405531636527
ENST00000327813KREMEN1chr2229494941+ENST00000325157ENTHD1chr2240231963-2232365131596527
ENST00000407188KREMEN1chr2229494941+ENST00000325157ENTHD1chr2240231963-221334601577525

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400338ENST00000325157KREMEN1chr2229494941+ENTHD1chr2240231963-0.0007738280.9992262
ENST00000400335ENST00000325157KREMEN1chr2229494941+ENTHD1chr2240231963-0.0007738280.9992262
ENST00000327813ENST00000325157KREMEN1chr2229494941+ENTHD1chr2240231963-0.0007955150.99920446
ENST00000407188ENST00000325157KREMEN1chr2229494941+ENTHD1chr2240231963-0.0005463820.9994536

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Fusion Genomic Features for KREMEN1-ENTHD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KREMEN1-ENTHD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29494941/chr22:40231963)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KREMEN1

Q96MU8

ENTHD1

Q8IYW4

FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. {ECO:0000250|UniProtKB:Q90Y90, ECO:0000250|UniProtKB:Q99N43}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000327813+31031_114117493.0DomainKringle
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000400335+3931_114117459.0DomainKringle
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000407188+3931_114115474.0DomainKringle
TgeneENTHD1chr22:29494941chr22:40231963ENST0000032515727543_574197608.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000327813+310116_210117493.0DomainWSC
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000327813+310214_321117493.0DomainCUB
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000400335+39116_210117459.0DomainWSC
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000400335+39214_321117459.0DomainCUB
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000407188+39116_210115474.0DomainWSC
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000407188+39214_321115474.0DomainCUB
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000327813+310414_473117493.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000400335+39414_473117459.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000407188+39414_473115474.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000327813+31021_392117493.0Topological domainExtracellular
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000400335+3921_392117459.0Topological domainExtracellular
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000407188+3921_392115474.0Topological domainExtracellular
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000327813+310393_413117493.0TransmembraneHelical
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000400335+39393_413117459.0TransmembraneHelical
HgeneKREMEN1chr22:29494941chr22:40231963ENST00000407188+39393_413115474.0TransmembraneHelical
TgeneENTHD1chr22:29494941chr22:40231963ENST00000325157279_141197608.0DomainENTH


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Fusion Gene Sequence for KREMEN1-ENTHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43448_43448_1_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000327813_ENTHD1_chr22_40231963_ENST00000325157_length(transcript)=2232nt_BP=365nt
GCACTGACGGCCCATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCGCCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCC
CGGCCTCGGCCCCGGACCCGAGTGTTTCACAGCCAATGGTGCGGATTATAGGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCC
ATGTCTGTTTTGGAACGAGACTTTCCAGCATCCATACAACACTCTGAAATACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTG
CAGAAATCCAGATGGAGACGTGAGCCCCTGGTGCTATGTGGCAGAGCACGAGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTG
CCAGAGAAATGTGTGCAAGGCAGGATTGAAACAAGAGCATTGCCAAGATGTTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACT
TCCACTCAAGATTCATGGTTGGAAATCAACAGAGGACCTGATGACATTTTTGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCC
TTCCATTGTCTCTCCAATCACTTGCTTGTCAGAAGCAGAAGAAGTTTGTAATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAA
TAGTCCTTCTGGGCAGAGAGATGTGAGTTTGGACAAGAGATCAGATGGTATCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACC
TTTAGAAAAGCAATCAGCTGCAGAAGGTCTTAAAACATTGACAATTTTACCAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGA
CTTAAGGGTATCAAAGTCAGATTCTACTTTCCATAACCAGGCCTCTGTAGAAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCG
AGTGAAGGAGATTGTAATCAACAAGGCCTACCAGAAACCAGCACAATCCAGCATTCAGATGGATGATAAAATCCTCAAGACAACCACACG
GGTTTCAACTGCTTCTGAGGGAGCATCTTCCTTTTCTCCTTTATCCATGTCATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCT
CTTATCACCAATTCTGGCCGGACCTTCCTTCTGGACTCTGTCCCATCAACAGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGC
CAAGCTGCATCACTCCTTTGCTTCTAGGGGCCCAGTGTCTTCTGATGTAGAGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAA
TAACTCTGATTCTGCTAAAAAGAATATAAGTCACATTTCTAGTAGTCACTGGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCC
TCTGTCCTGTTCTGGTTTTCAGTCAACCAAAGACTTCCCCCAGGAACCTGAAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAA
ACGTGCGATCGCTAGATTACATGAAGATCTGAGCACAGTGATCCAAGAACTTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAA
TAGTTCACAAATAAGCCAGTCTTCCCAGGTCCCCCAGTCTTCTGAGGGGAGCTCAGATCAGATCTAATCATCACAATATCTATTTTTGAT
AGAACTCGTGTGGTTCCACTTCCCCAAGACTTACGTTAGCATTGTATAAATTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTT
CCTTGTCAGGTTTATTAGCAAGTATCTTTCAAACTAATACTTTCATTTGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATA
ATTTCAGATTTAGATATTAGTTCATTTGAAACAGAAGAGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAA
ATTGTGGTAAGACCTCAAACTGCAAATGACTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGA
GCTTGTTAACAAGCCTCTGAGGTGACCTAGGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAA
CCAAGGGCCAGAAATCTTTTCTTTCTTCCAGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGT

>43448_43448_1_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000327813_ENTHD1_chr22_40231963_ENST00000325157_length(amino acids)=527AA_BP=118
MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPD
GDVSPWCYVAEHEDGVYWKYCEIPACQRNVCKAGLKQEHCQDVHLPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVS
PITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVS
KSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPI
LAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCS

--------------------------------------------------------------
>43448_43448_2_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000400335_ENTHD1_chr22_40231963_ENST00000325157_length(transcript)=2272nt_BP=405nt
CGCGCTGCCCCCTTTACCCCGGGCCGCGCCCCGGGGCCCCGCACTGACGGCCCATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCG
CCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCCCGGCCTCGGCCCCGGACCCGAGTGTTTCACAGCCAATGGTGCGGATTATA
GGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCCATGTCTGTTTTGGAACGAGACTTTCCAGCATCCATACAACACTCTGAAAT
ACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTGCAGAAATCCAGATGGAGACGTGAGCCCCTGGTGCTATGTGGCAGAGCACG
AGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTGCCAGAGAAATGTGTGCAAGGCAGGATTGAAACAAGAGCATTGCCAAGATG
TTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACTTCCACTCAAGATTCATGGTTGGAAATCAACAGAGGACCTGATGACATTTT
TGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCCTTCCATTGTCTCTCCAATCACTTGCTTGTCAGAAGCAGAAGAAGTTTGTA
ATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAATAGTCCTTCTGGGCAGAGAGATGTGAGTTTGGACAAGAGATCAGATGGTA
TCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACCTTTAGAAAAGCAATCAGCTGCAGAAGGTCTTAAAACATTGACAATTTTAC
CAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGACTTAAGGGTATCAAAGTCAGATTCTACTTTCCATAACCAGGCCTCTGTAG
AAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCGAGTGAAGGAGATTGTAATCAACAAGGCCTACCAGAAACCAGCACAATCCA
GCATTCAGATGGATGATAAAATCCTCAAGACAACCACACGGGTTTCAACTGCTTCTGAGGGAGCATCTTCCTTTTCTCCTTTATCCATGT
CATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCTCTTATCACCAATTCTGGCCGGACCTTCCTTCTGGACTCTGTCCCATCAAC
AGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGCCAAGCTGCATCACTCCTTTGCTTCTAGGGGCCCAGTGTCTTCTGATGTAG
AGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAATAACTCTGATTCTGCTAAAAAGAATATAAGTCACATTTCTAGTAGTCACT
GGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCCTCTGTCCTGTTCTGGTTTTCAGTCAACCAAAGACTTCCCCCAGGAACCTG
AAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAAACGTGCGATCGCTAGATTACATGAAGATCTGAGCACAGTGATCCAAGAAC
TTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAATAGTTCACAAATAAGCCAGTCTTCCCAGGTCCCCCAGTCTTCTGAGGGGA
GCTCAGATCAGATCTAATCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCACTTCCCCAAGACTTACGTTAGCATTGTATAAA
TTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGCAAGTATCTTTCAAACTAATACTTTCATTTGG
GTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTAGTTCATTTGAAACAGAAGAGAATTTCATTCT
TTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAACTGCAAATGACTATTCAAGAGCTTTTGGATA
AGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTCTGAGGTGACCTAGGAGGATTGAGTTTGGGGGTA
TACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGGCCAGAAATCTTTTCTTTCTTCCAGATGCTAGTGTTAGGAGTTA
AATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGTCAATGTATATTGCAAGGTGAATTCAAATGCATCCTTTTATTCTACTTCAG

>43448_43448_2_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000400335_ENTHD1_chr22_40231963_ENST00000325157_length(amino acids)=527AA_BP=118
MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPD
GDVSPWCYVAEHEDGVYWKYCEIPACQRNVCKAGLKQEHCQDVHLPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVS
PITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVS
KSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPI
LAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCS

--------------------------------------------------------------
>43448_43448_3_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000400338_ENTHD1_chr22_40231963_ENST00000325157_length(transcript)=2272nt_BP=405nt
CGCGCTGCCCCCTTTACCCCGGGCCGCGCCCCGGGGCCCCGCACTGACGGCCCATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCG
CCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCCCGGCCTCGGCCCCGGACCCGAGTGTTTCACAGCCAATGGTGCGGATTATA
GGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCCATGTCTGTTTTGGAACGAGACTTTCCAGCATCCATACAACACTCTGAAAT
ACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTGCAGAAATCCAGATGGAGACGTGAGCCCCTGGTGCTATGTGGCAGAGCACG
AGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTGCCAGAGAAATGTGTGCAAGGCAGGATTGAAACAAGAGCATTGCCAAGATG
TTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACTTCCACTCAAGATTCATGGTTGGAAATCAACAGAGGACCTGATGACATTTT
TGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCCTTCCATTGTCTCTCCAATCACTTGCTTGTCAGAAGCAGAAGAAGTTTGTA
ATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAATAGTCCTTCTGGGCAGAGAGATGTGAGTTTGGACAAGAGATCAGATGGTA
TCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACCTTTAGAAAAGCAATCAGCTGCAGAAGGTCTTAAAACATTGACAATTTTAC
CAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGACTTAAGGGTATCAAAGTCAGATTCTACTTTCCATAACCAGGCCTCTGTAG
AAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCGAGTGAAGGAGATTGTAATCAACAAGGCCTACCAGAAACCAGCACAATCCA
GCATTCAGATGGATGATAAAATCCTCAAGACAACCACACGGGTTTCAACTGCTTCTGAGGGAGCATCTTCCTTTTCTCCTTTATCCATGT
CATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCTCTTATCACCAATTCTGGCCGGACCTTCCTTCTGGACTCTGTCCCATCAAC
AGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGCCAAGCTGCATCACTCCTTTGCTTCTAGGGGCCCAGTGTCTTCTGATGTAG
AGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAATAACTCTGATTCTGCTAAAAAGAATATAAGTCACATTTCTAGTAGTCACT
GGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCCTCTGTCCTGTTCTGGTTTTCAGTCAACCAAAGACTTCCCCCAGGAACCTG
AAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAAACGTGCGATCGCTAGATTACATGAAGATCTGAGCACAGTGATCCAAGAAC
TTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAATAGTTCACAAATAAGCCAGTCTTCCCAGGTCCCCCAGTCTTCTGAGGGGA
GCTCAGATCAGATCTAATCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCACTTCCCCAAGACTTACGTTAGCATTGTATAAA
TTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGCAAGTATCTTTCAAACTAATACTTTCATTTGG
GTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTAGTTCATTTGAAACAGAAGAGAATTTCATTCT
TTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAACTGCAAATGACTATTCAAGAGCTTTTGGATA
AGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTCTGAGGTGACCTAGGAGGATTGAGTTTGGGGGTA
TACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGGCCAGAAATCTTTTCTTTCTTCCAGATGCTAGTGTTAGGAGTTA
AATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGTCAATGTATATTGCAAGGTGAATTCAAATGCATCCTTTTATTCTACTTCAG

>43448_43448_3_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000400338_ENTHD1_chr22_40231963_ENST00000325157_length(amino acids)=527AA_BP=118
MAPPAARLALLSAAALTLAARPAPSPGLGPGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPD
GDVSPWCYVAEHEDGVYWKYCEIPACQRNVCKAGLKQEHCQDVHLPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVS
PITCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVS
KSDSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPI
LAGPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCS

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>43448_43448_4_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000407188_ENTHD1_chr22_40231963_ENST00000325157_length(transcript)=2213nt_BP=346nt
ATGGCGCCGCCAGCCGCCCGCCTCGCCCTGCTCTCCGCCGCGGCGCTCACGCTGGCGGCCCGGCCCGCGCCTAGCCCCGGCCTCGGCCCC
GAGTGTTTCACAGCCAATGGTGCGGATTATAGGGGAACACAGAACTGGACAGCACTACAAGGCGGGAAGCCATGTCTGTTTTGGAACGAG
ACTTTCCAGCATCCATACAACACTCTGAAATACCCCAACGGGGAGGGGGGCCTGGGTGAGCACAACTATTGCAGAAATCCAGATGGAGAC
GTGAGCCCCTGGTGCTATGTGGCAGAGCACGAGGATGGTGTCTACTGGAAGTACTGTGAGATACCTGCTTGCCAGAGAAATGTGTGCAAG
GCAGGATTGAAACAAGAGCATTGCCAAGATGTTCATTTGCCTACAGAAACTATGTTGTCCCAGGAAACACTTCCACTCAAGATTCATGGT
TGGAAATCAACAGAGGACCTGATGACATTTTTGGATGATGATCCAGAGCTGCCTTTACTAGCAACACCTCCTTCCATTGTCTCTCCAATC
ACTTGCTTGTCAGAAGCAGAAGAAGTTTGTAATCTTTCGGGTGCAGATGCTGTGCCTACTCTCTCAGAAAATAGTCCTTCTGGGCAGAGA
GATGTGAGTTTGGACAAGAGATCAGATGGTATCTTTACAAATACTGTCACAGAAAACCTCTTGGAAACACCTTTAGAAAAGCAATCAGCT
GCAGAAGGTCTTAAAACATTGACAATTTTACCAGCATGTTGGTCAAGTAAAGAGGAGTTTATCAGCCCCGACTTAAGGGTATCAAAGTCA
GATTCTACTTTCCATAACCAGGCCTCTGTAGAAACACTCTGTCTCTCTCCCTCATTCAAAATATTTGACCGAGTGAAGGAGATTGTAATC
AACAAGGCCTACCAGAAACCAGCACAATCCAGCATTCAGATGGATGATAAAATCCTCAAGACAACCACACGGGTTTCAACTGCTTCTGAG
GGAGCATCTTCCTTTTCTCCTTTATCCATGTCATCTCCTGATTTAGCCTCTCCAGAGAAGTCAGCTCATCTCTTATCACCAATTCTGGCC
GGACCTTCCTTCTGGACTCTGTCCCATCAACAGTTGTCTTCTACCTCCTTTAAAGATGAAGATAAGACAGCCAAGCTGCATCACTCCTTT
GCTTCTAGGGGCCCAGTGTCTTCTGATGTAGAGGAAAATGATAGCCTCAATCTACTGGGAATTCTTCCAAATAACTCTGATTCTGCTAAA
AAGAATATAAGTCACATTTCTAGTAGTCACTGGGGGGAGTTTTCCACCCAAAATGTAGACCAGTTCATCCCTCTGTCCTGTTCTGGTTTT
CAGTCAACCAAAGACTTCCCCCAGGAACCTGAAGCAAAGAATTCCATTAGTGTTCTTTTAAGGGAGGTAAAACGTGCGATCGCTAGATTA
CATGAAGATCTGAGCACAGTGATCCAAGAACTTAATGTCATCAATAACATCTTGATGAGCATGAGTCTGAATAGTTCACAAATAAGCCAG
TCTTCCCAGGTCCCCCAGTCTTCTGAGGGGAGCTCAGATCAGATCTAATCATCACAATATCTATTTTTGATAGAACTCGTGTGGTTCCAC
TTCCCCAAGACTTACGTTAGCATTGTATAAATTCATATTATTATGGCAAAAAAGGGGATGGTTTAATTTTTCCTTGTCAGGTTTATTAGC
AAGTATCTTTCAAACTAATACTTTCATTTGGGTGGTTTATTTTTTAAAAGGGAAAGATGTCACCTTTGATAATTTCAGATTTAGATATTA
GTTCATTTGAAACAGAAGAGAATTTCATTCTTTCATGCTCTGTACCTCAAATGGGTTAAGCATTAGTGAAAATTGTGGTAAGACCTCAAA
CTGCAAATGACTATTCAAGAGCTTTTGGATAAGGAGGCAGGAAGAAGCTCTTTATCTTTCAACTGTATGGAGCTTGTTAACAAGCCTCTG
AGGTGACCTAGGAGGATTGAGTTTGGGGGTATACATTTCACACATTCTTTTGCAAGTTTTAGGTTCTGCAACCAAGGGCCAGAAATCTTT
TCTTTCTTCCAGATGCTAGTGTTAGGAGTTAAATGGAAACAAGAAGGACATGGGGCAAATGTTTTTACTGTCAATGTATATTGCAAGGTG

>43448_43448_4_KREMEN1-ENTHD1_KREMEN1_chr22_29494941_ENST00000407188_ENTHD1_chr22_40231963_ENST00000325157_length(amino acids)=525AA_BP=116
MAPPAARLALLSAAALTLAARPAPSPGLGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGD
VSPWCYVAEHEDGVYWKYCEIPACQRNVCKAGLKQEHCQDVHLPTETMLSQETLPLKIHGWKSTEDLMTFLDDDPELPLLATPPSIVSPI
TCLSEAEEVCNLSGADAVPTLSENSPSGQRDVSLDKRSDGIFTNTVTENLLETPLEKQSAAEGLKTLTILPACWSSKEEFISPDLRVSKS
DSTFHNQASVETLCLSPSFKIFDRVKEIVINKAYQKPAQSSIQMDDKILKTTTRVSTASEGASSFSPLSMSSPDLASPEKSAHLLSPILA
GPSFWTLSHQQLSSTSFKDEDKTAKLHHSFASRGPVSSDVEENDSLNLLGILPNNSDSAKKNISHISSSHWGEFSTQNVDQFIPLSCSGF

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Fusion Gene PPI Analysis for KREMEN1-ENTHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KREMEN1-ENTHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KREMEN1-ENTHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource