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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KREMEN1-ZNRF3 (FusionGDB2 ID:43455)

Fusion Gene Summary for KREMEN1-ZNRF3

check button Fusion gene summary
Fusion gene informationFusion gene name: KREMEN1-ZNRF3
Fusion gene ID: 43455
HgeneTgene
Gene symbol

KREMEN1

ZNRF3

Gene ID

83999

84133

Gene namekringle containing transmembrane protein 1zinc and ring finger 3
SynonymsECTD13|KREMEN|KRM1BK747E2.3|RNF203
Cytomap

22q12.1

22q12.1

Type of geneprotein-codingprotein-coding
Descriptionkremen protein 1dickkopf receptorkringle domain-containing transmembrane protein 1kringle-coding gene marking the eye and the nosekringle-containing protein marking the eye and the noseE3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3
Modification date2020031320200313
UniProtAcc

Q96MU8

.
Ensembl transtripts involved in fusion geneENST00000479755, ENST00000327813, 
ENST00000400335, ENST00000400338, 
ENST00000407188, 		ENST00000332811, 
ENST00000402174, ENST00000406323, 
ENST00000544604, 
Fusion gene scores* DoF score9 X 8 X 7=50416 X 21 X 8=2688
# samples 1121
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2688*10)=-3.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KREMEN1 [Title/Abstract] AND ZNRF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKREMEN1(29517469)-ZNRF3(29449566), # samples:2
ZNRF3(29383189)-KREMEN1(29490245), # samples:2
Anticipated loss of major functional domain due to fusion event.KREMEN1-ZNRF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KREMEN1-ZNRF3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KREMEN1-ZNRF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ZNRF3-KREMEN1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ZNRF3-KREMEN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZNRF3-KREMEN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNRF3

GO:0016567

protein ubiquitination

22575959


check buttonFusion gene breakpoints across KREMEN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNRF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EUKREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
ChimerDB4ESCATCGA-VR-A8EUKREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
ChimerDB4LUSCTCGA-L3-A524KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+


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Fusion Gene ORF analysis for KREMEN1-ZNRF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000479755ENST00000332811KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
3UTR-3CDSENST00000479755ENST00000402174KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
3UTR-3CDSENST00000479755ENST00000406323KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
3UTR-3CDSENST00000479755ENST00000544604KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
Frame-shiftENST00000327813ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000327813ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000327813ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000327813ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000327813ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000327813ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000400335ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000400335ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000400335ENST00000332811KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
Frame-shiftENST00000400335ENST00000402174KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
Frame-shiftENST00000400335ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000400335ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000400335ENST00000406323KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
Frame-shiftENST00000400335ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000400335ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000400335ENST00000544604KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
Frame-shiftENST00000400338ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000400338ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000400338ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000400338ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000400338ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000400338ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000407188ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000407188ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000407188ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000407188ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
Frame-shiftENST00000407188ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
Frame-shiftENST00000407188ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
In-frameENST00000327813ENST00000332811KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000327813ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
In-frameENST00000327813ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
In-frameENST00000327813ENST00000402174KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000327813ENST00000406323KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000327813ENST00000544604KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000400335ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
In-frameENST00000400335ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
In-frameENST00000400338ENST00000332811KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000400338ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
In-frameENST00000400338ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
In-frameENST00000400338ENST00000402174KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000400338ENST00000406323KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000400338ENST00000544604KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000407188ENST00000332811KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000407188ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
In-frameENST00000407188ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
In-frameENST00000407188ENST00000402174KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000407188ENST00000406323KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
In-frameENST00000407188ENST00000544604KREMEN1chr22

29538088

+ZNRF3chr22

29438482

+
intron-3CDSENST00000479755ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
intron-3CDSENST00000479755ENST00000332811KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
intron-3CDSENST00000479755ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
intron-3CDSENST00000479755ENST00000402174KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
intron-3CDSENST00000479755ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
intron-3CDSENST00000479755ENST00000406323KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+
intron-3CDSENST00000479755ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449566

+
intron-3CDSENST00000479755ENST00000544604KREMEN1chr22

29517469

+ZNRF3chr22

29449567

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for KREMEN1-ZNRF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
KREMEN1chr2229517469+ZNRF3chr2229449566+0.027252080.97274786
KREMEN1chr2229538088+ZNRF3chr2229438482+4.40E-050.999956
KREMEN1chr2229517469+ZNRF3chr2229449566+0.027252080.97274786
KREMEN1chr2229538088+ZNRF3chr2229438482+4.40E-050.999956

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for KREMEN1-ZNRF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29517469/chr22:29449566)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KREMEN1

Q96MU8

.
FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification. {ECO:0000250|UniProtKB:Q90Y90, ECO:0000250|UniProtKB:Q99N43}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000327813+41031_114159493.0DomainKringle
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000400335+4931_114159459.0DomainKringle
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000407188+4931_114157474.0DomainKringle
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000327813+41031_114159493.0DomainKringle
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000400335+4931_114159459.0DomainKringle
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000407188+4931_114157474.0DomainKringle
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000327813+910116_210472493.0DomainWSC
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000327813+910214_321472493.0DomainCUB
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000327813+91031_114472493.0DomainKringle
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000327813+910414_473472493.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000327813+91021_392472493.0Topological domainExtracellular
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000327813+910393_413472493.0TransmembraneHelical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000033281119241_93642837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29538088chr22:29438482ENST000003328111956_21942837.0Topological domainExtracellular
TgeneZNRF3chr22:29538088chr22:29438482ENST0000040217419241_93642837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29538088chr22:29438482ENST000004021741956_21942837.0Topological domainExtracellular
TgeneZNRF3chr22:29538088chr22:29438482ENST0000040632308241_93642837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29538088chr22:29438482ENST000004063230856_21942837.0Topological domainExtracellular
TgeneZNRF3chr22:29538088chr22:29438482ENST0000054460419241_936142937.0Topological domainCytoplasmic
TgeneZNRF3chr22:29538088chr22:29438482ENST0000033281119220_24042837.0TransmembraneHelical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000040217419220_24042837.0TransmembraneHelical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000040632308220_24042837.0TransmembraneHelical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000054460419220_240142937.0TransmembraneHelical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000033281119293_33442837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000040217419293_33442837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000040632308293_33442837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29538088chr22:29438482ENST0000054460419293_334142937.0Zinc fingerRING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000327813+410116_210159493.0DomainWSC
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000327813+410214_321159493.0DomainCUB
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000400335+49116_210159459.0DomainWSC
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000400335+49214_321159459.0DomainCUB
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000407188+49116_210157474.0DomainWSC
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000407188+49214_321157474.0DomainCUB
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000327813+410116_210159493.0DomainWSC
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000327813+410214_321159493.0DomainCUB
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000400335+49116_210159459.0DomainWSC
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000400335+49214_321159459.0DomainCUB
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000407188+49116_210157474.0DomainWSC
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000407188+49214_321157474.0DomainCUB
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000400335+19116_2100459.0DomainWSC
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000400335+19214_3210459.0DomainCUB
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000400335+1931_1140459.0DomainKringle
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000407188+19116_2100474.0DomainWSC
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000407188+19214_3210474.0DomainCUB
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000407188+1931_1140474.0DomainKringle
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000327813+410414_473159493.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000400335+49414_473159459.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000407188+49414_473157474.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000327813+410414_473159493.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000400335+49414_473159459.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000407188+49414_473157474.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000400335+19414_4730459.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000407188+19414_4730474.0RegionEssential for apoptotic activity
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000327813+41021_392159493.0Topological domainExtracellular
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000400335+4921_392159459.0Topological domainExtracellular
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000407188+4921_392157474.0Topological domainExtracellular
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000327813+41021_392159493.0Topological domainExtracellular
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000400335+4921_392159459.0Topological domainExtracellular
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000407188+4921_392157474.0Topological domainExtracellular
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000400335+1921_3920459.0Topological domainExtracellular
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000407188+1921_3920474.0Topological domainExtracellular
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000327813+410393_413159493.0TransmembraneHelical
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000400335+49393_413159459.0TransmembraneHelical
HgeneKREMEN1chr22:29517469chr22:29449566ENST00000407188+49393_413157474.0TransmembraneHelical
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000327813+410393_413159493.0TransmembraneHelical
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000400335+49393_413159459.0TransmembraneHelical
HgeneKREMEN1chr22:29517469chr22:29449567ENST00000407188+49393_413157474.0TransmembraneHelical
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000400335+19393_4130459.0TransmembraneHelical
HgeneKREMEN1chr22:29538088chr22:29438482ENST00000407188+19393_4130474.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000033281179241_936822837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449566ENST000003328117956_219822837.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449566ENST0000040217479241_936822837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449566ENST000004021747956_219822837.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449566ENST0000040632368241_936822837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449566ENST000004063236856_219822837.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449566ENST0000054460479241_936922937.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449566ENST000005446047956_219922937.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449567ENST0000033281179241_936822837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449567ENST000003328117956_219822837.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449567ENST0000040217479241_936822837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449567ENST000004021747956_219822837.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449567ENST0000040632368241_936822837.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449567ENST000004063236856_219822837.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449567ENST0000054460479241_936922937.0Topological domainCytoplasmic
TgeneZNRF3chr22:29517469chr22:29449567ENST000005446047956_219922937.0Topological domainExtracellular
TgeneZNRF3chr22:29538088chr22:29438482ENST000005446041956_219142937.0Topological domainExtracellular
TgeneZNRF3chr22:29517469chr22:29449566ENST0000033281179220_240822837.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000040217479220_240822837.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000040632368220_240822837.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000054460479220_240922937.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000033281179220_240822837.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000040217479220_240822837.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000040632368220_240822837.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000054460479220_240922937.0TransmembraneHelical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000033281179293_334822837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000040217479293_334822837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000040632368293_334822837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449566ENST0000054460479293_334922937.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000033281179293_334822837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000040217479293_334822837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000040632368293_334822837.0Zinc fingerRING-type%3B atypical
TgeneZNRF3chr22:29517469chr22:29449567ENST0000054460479293_334922937.0Zinc fingerRING-type%3B atypical


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Fusion Gene Sequence for KREMEN1-ZNRF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for KREMEN1-ZNRF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KREMEN1-ZNRF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KREMEN1-ZNRF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource