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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KRIT1-CDK6 (FusionGDB2 ID:43461) |
Fusion Gene Summary for KRIT1-CDK6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KRIT1-CDK6 | Fusion gene ID: 43461 | Hgene | Tgene | Gene symbol | KRIT1 | CDK6 | Gene ID | 889 | 1021 |
| Gene name | KRIT1 ankyrin repeat containing | cyclin dependent kinase 6 | |
| Synonyms | CAM|CCM1 | MCPH12|PLSTIRE | |
| Cytomap | 7q21.2 | 7q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | krev interaction trapped protein 1ankyrin repeat-containing protein Krit1cerebral cavernous malformations 1 proteinkrev interaction trapped 1 | cyclin-dependent kinase 6cell division protein kinase 6serine/threonine-protein kinase PLSTIRE | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | O00522 | Q00534 | |
| Ensembl transtripts involved in fusion gene | ENST00000340022, ENST00000394503, ENST00000394505, ENST00000394507, ENST00000412043, ENST00000466166, | ENST00000491250, ENST00000265734, ENST00000424848, | |
| Fusion gene scores | * DoF score | 2 X 4 X 2=16 | 10 X 11 X 5=550 |
| # samples | 4 | 11 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/550*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KRIT1 [Title/Abstract] AND CDK6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KRIT1(91871348)-CDK6(92247521), # samples:2 KRIT1(91871347)-CDK6(92247521), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | KRIT1-CDK6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. KRIT1-CDK6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KRIT1-CDK6 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KRIT1-CDK6 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. KRIT1-CDK6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDK6 | GO:0001954 | positive regulation of cell-matrix adhesion | 10205165 |
| Tgene | CDK6 | GO:0003323 | type B pancreatic cell development | 20668294 |
| Tgene | CDK6 | GO:0006468 | protein phosphorylation | 8114739 |
| Tgene | CDK6 | GO:0010468 | regulation of gene expression | 15254224 |
| Tgene | CDK6 | GO:0045638 | negative regulation of myeloid cell differentiation | 17431401 |
| Tgene | CDK6 | GO:0045656 | negative regulation of monocyte differentiation | 26542173 |
| Tgene | CDK6 | GO:0045668 | negative regulation of osteoblast differentiation | 15254224 |
| Tgene | CDK6 | GO:0045786 | negative regulation of cell cycle | 14985467 |
| Tgene | CDK6 | GO:2000773 | negative regulation of cellular senescence | 17420273 |
| Fusion gene breakpoints across KRIT1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CDK6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-L5-A4OW-01A | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| ChimerDB4 | ESCA | TCGA-L5-A4OW | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
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Fusion Gene ORF analysis for KRIT1-CDK6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000340022 | ENST00000491250 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000340022 | ENST00000491250 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000394503 | ENST00000491250 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000394503 | ENST00000491250 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000394505 | ENST00000491250 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000394505 | ENST00000491250 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000394507 | ENST00000491250 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000394507 | ENST00000491250 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000412043 | ENST00000491250 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| 5CDS-intron | ENST00000412043 | ENST00000491250 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000340022 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000340022 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000340022 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000340022 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000394505 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000394505 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000394505 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000394505 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000412043 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000412043 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000412043 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| Frame-shift | ENST00000412043 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394503 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394503 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394503 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394503 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394507 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394507 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394507 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| In-frame | ENST00000394507 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| intron-3CDS | ENST00000466166 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| intron-3CDS | ENST00000466166 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| intron-3CDS | ENST00000466166 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| intron-3CDS | ENST00000466166 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| intron-intron | ENST00000466166 | ENST00000491250 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - |
| intron-intron | ENST00000466166 | ENST00000491250 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000394507 | KRIT1 | chr7 | 91871348 | - | ENST00000265734 | CDK6 | chr7 | 92247521 | - | 11388 | 886 | 7201 | 7668 | 155 |
| ENST00000394507 | KRIT1 | chr7 | 91871348 | - | ENST00000424848 | CDK6 | chr7 | 92247521 | - | 1169 | 886 | 809 | 1168 | 120 |
| ENST00000394503 | KRIT1 | chr7 | 91871348 | - | ENST00000265734 | CDK6 | chr7 | 92247521 | - | 11001 | 499 | 6814 | 7281 | 155 |
| ENST00000394503 | KRIT1 | chr7 | 91871348 | - | ENST00000424848 | CDK6 | chr7 | 92247521 | - | 782 | 499 | 422 | 781 | 120 |
| ENST00000394507 | KRIT1 | chr7 | 91871347 | - | ENST00000265734 | CDK6 | chr7 | 92247521 | - | 11388 | 886 | 7201 | 7668 | 155 |
| ENST00000394507 | KRIT1 | chr7 | 91871347 | - | ENST00000424848 | CDK6 | chr7 | 92247521 | - | 1169 | 886 | 809 | 1168 | 120 |
| ENST00000394503 | KRIT1 | chr7 | 91871347 | - | ENST00000265734 | CDK6 | chr7 | 92247521 | - | 11001 | 499 | 6814 | 7281 | 155 |
| ENST00000394503 | KRIT1 | chr7 | 91871347 | - | ENST00000424848 | CDK6 | chr7 | 92247521 | - | 782 | 499 | 422 | 781 | 120 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000394507 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - | 0.022356322 | 0.97764367 |
| ENST00000394507 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - | 0.013711154 | 0.9862889 |
| ENST00000394503 | ENST00000265734 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - | 0.02303743 | 0.97696257 |
| ENST00000394503 | ENST00000424848 | KRIT1 | chr7 | 91871348 | - | CDK6 | chr7 | 92247521 | - | 0.023126315 | 0.9768737 |
| ENST00000394507 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - | 0.022356322 | 0.97764367 |
| ENST00000394507 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - | 0.013711154 | 0.9862889 |
| ENST00000394503 | ENST00000265734 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - | 0.02303743 | 0.97696257 |
| ENST00000394503 | ENST00000424848 | KRIT1 | chr7 | 91871347 | - | CDK6 | chr7 | 92247521 | - | 0.023126315 | 0.9768737 |
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Fusion Genomic Features for KRIT1-CDK6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KRIT1-CDK6 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:91871348/chr7:92247521) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KRIT1 | CDK6 |
| FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels. {ECO:0000250|UniProtKB:Q6S5J6, ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:20616044, ECO:0000269|PubMed:20668652, ECO:0000269|PubMed:21633110, ECO:0000269|PubMed:23317506}. | FUNCTION: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663). {ECO:0000269|PubMed:12833137, ECO:0000269|PubMed:14985467, ECO:0000269|PubMed:15254224, ECO:0000269|PubMed:15809340, ECO:0000269|PubMed:17420273, ECO:0000269|PubMed:17431401, ECO:0000269|PubMed:20333249, ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:23918663, ECO:0000269|PubMed:8114739}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 420_734 | 34 | 689.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 420_734 | 34 | 689.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 420_734 | 34 | 737.0 | Domain | FERM |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 1_170 | 34 | 689.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 1_170 | 34 | 689.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 1_170 | 34 | 737.0 | Region | Note=N-terminal domain similar to Nudix hydrolase domain |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 287_316 | 34 | 689.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 320_350 | 34 | 689.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 354_383 | 34 | 689.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 388_419 | 34 | 689.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 287_316 | 34 | 689.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 320_350 | 34 | 689.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 354_383 | 34 | 689.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 388_419 | 34 | 689.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 287_316 | 34 | 737.0 | Repeat | ANK 1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 320_350 | 34 | 737.0 | Repeat | ANK 2 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 354_383 | 34 | 737.0 | Repeat | ANK 3 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 388_419 | 34 | 737.0 | Repeat | ANK 4 |
| Tgene | CDK6 | chr7:91871347 | chr7:92247521 | ENST00000265734 | 5 | 8 | 13_300 | 232 | 327.0 | Domain | Protein kinase | |
| Tgene | CDK6 | chr7:91871347 | chr7:92247521 | ENST00000424848 | 5 | 8 | 13_300 | 232 | 327.0 | Domain | Protein kinase | |
| Tgene | CDK6 | chr7:91871348 | chr7:92247521 | ENST00000265734 | 5 | 8 | 13_300 | 232 | 327.0 | Domain | Protein kinase | |
| Tgene | CDK6 | chr7:91871348 | chr7:92247521 | ENST00000424848 | 5 | 8 | 13_300 | 232 | 327.0 | Domain | Protein kinase | |
| Tgene | CDK6 | chr7:91871347 | chr7:92247521 | ENST00000265734 | 5 | 8 | 19_27 | 232 | 327.0 | Nucleotide binding | ATP | |
| Tgene | CDK6 | chr7:91871347 | chr7:92247521 | ENST00000424848 | 5 | 8 | 19_27 | 232 | 327.0 | Nucleotide binding | ATP | |
| Tgene | CDK6 | chr7:91871348 | chr7:92247521 | ENST00000265734 | 5 | 8 | 19_27 | 232 | 327.0 | Nucleotide binding | ATP | |
| Tgene | CDK6 | chr7:91871348 | chr7:92247521 | ENST00000424848 | 5 | 8 | 19_27 | 232 | 327.0 | Nucleotide binding | ATP |
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Fusion Gene Sequence for KRIT1-CDK6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >43461_43461_1_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394503_CDK6_chr7_92247521_ENST00000265734_length(transcript)=11001nt_BP=499nt ATAGCCACGGTAACGGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCT GAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTC ATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACG CTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAA CCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAA GAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATG TTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTAC TTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCA AAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGAGGCCTCAGCAGCCGCCTTAAGCTGATCC TGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCAAGCCCTACAGAGCTGTGGAGGATTGCTATCTGGAGGCCTTCCAGCTGCT GTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAGTTTACTGTTTTGAAATCAATGCAAGAGTGATTGCAGCTTTATGTTCATT TGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAATTCCAGAAGAAGAGAAGCTGCTGACCAATTGTGCTGCCATTTGATTTTT CTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGCACAGCTGAGTTATGATGTAATCTCTCTGCAGCTGCCGGGCCTGATTTGG TACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGAGATTCTGTGATCTTTTAAAGTGTTACT TTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAGGTGGTCAGTAAATAACAGGCATTTGTTCACTGAAGGTGATTCACCAAAA TAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCATTTCTTTTCTGGCCAAAAGCAGTAAATTTGCTAGCAGTAAAAGATGAAG TTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATATTTTAAGAGATGTGCATGCATTCTATTTAGTCTTCAGAATGCTGAATTTA CTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGCTTTATCATTTCTTTTGGAAAATAGCCTGTAAGCTTTTTATTACTTGCTA TAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAGAATAGAAAGCCTTTATTTCCTGGTTTGAAATTCCTTTCTTCCCTTTTTT TGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTGTTTTTAGGAATTTGTCAGAAACTCTTTCCTGTTTTGGTTTGGAGAGTAG TTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCTCATCTATTACACTGTACTTTCTGCCACACACTGCCTTGTTGGCAAAGTA TCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCTACCATTGTATAACTAATAACAGATTGCTTAAGCTGTTCCCATGCACCAC CTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGTCTCAGCTTATGGTTTATGGCCTCGATTCTGCAAACCTAACAGGGTCACA TATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTTGTTACCTAAATAATGAGTAGGATCTTGTTTTGTTTTATCACCAGCACAC AGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATAGAAGATATTTTCAGTGTCTTTACCTGAGGGTATGTCTTTAGCTATGTTT TAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCATCCCCCAGGCTGTGCTTATTTCTAGTGCCTTGTGCTCACTCCTGCTCTCT ACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCTTTTTCTCTTACTGTTTTCTCTACAGTCCTTTATATTTCATACCATCTCT GCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCAGAGGACACAGAAAGTATCTTTTGGAAAGTTTAGCCACCTGTGCTTTCTG ACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGATTATGTTTAGGGTTAGGATTTTCAAAGAATGGAGGTTGCTGCACTCAGA AAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTGAATTCTTTGCAGCTTAATGTGATATATGACTATCTTGAACAAGAGAAAA AACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGAACTATTCTTTTTTAATTGCTGTACTACTTAACATTGTTCTAATTCAGTA GCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATAAAGGAGATGGGCCATACAAATGTTTTCTACTTTCGTTGTGACAACATTG ATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGAATCCACAGCATTCAAGGTCAGGTCTACTCAAAGTCTCACATGGAAAAGT GAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGACATTTTTGCTAGGGCCTACAAATTGAATTTAAAAACTCACTGCACTGAT TCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAACATAGCTTTAGTTTTTGCTGTTGTAAAAGTGTTTTCATAAGTTCACTCAA GAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCTTTAGAATTTTAAATGAGTAGAGAGCTCAACTTTTATTCCTAGCATCTGC TTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAAAGCACAAACATTCTGGCATTCAATCGTTGGCAGATTATCTTCTGATGAC ACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAAAATCTGTCCCCAGTTCTTCCATCGGTGTAGTTGTTGCATTTGAGTGAAT ACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTTCTGAAATCCAGATCCAACACAAGCAGTCTTGCCGTTAGGGCATTTTGAA GCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCTTCTGTAACATATGGTTTCAAACATCTTTGCCAAAAGCTAAGCAGTGGTG AACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAGCTCATAGCAAGTTAAAATATTGTGACAGATTTGAAATCATGTTTGAATT TCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTGTTTGATGTTTGGTTCTGGCGGCTCAGGCATTTTGGGAACTGTTGCACAG GGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAGAAACTTGTCCATTTAGCTTTCATAAGAAATCCCATGGCAAAGGGTAATA AAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGTAAGAACCCAGTGGGTTGGAGCCTCCCACTTTGTCCCTCCTTTGAAGTGG ATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGCTTGGGGCCATTTCAGCCCCCTGTATTCTCATGATTTTCTCTCAGGAAGC ACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGACTTACTAAAAATAGTTGAAAATTATTCACCTAAGAATAGAATCTCAGCA TTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATGTTCCTATCTTAAATAAAGCATGTTTCTTTTCTATAGAGAAATGTATAGT TTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACTCTTAAATAGTACCAAACATTTTGAACTTTAAATTATGTATTTAAAGTGA GTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCCTATTAAAGTCAGTAATGGCCATTATTGTTCCATTGTGGAAATTAAATTA TGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTAAAATATTGCTTTTCTTTTAAGTGACAATTTGACTATTCTTATGATAAGC ACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATTGCATAGTTGAGTCTAGGAAAAAATAATGTTAAAAGTGAATATGCCACCA TAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTTACCCTGGAAAGAAAATATTGGAATGTTATTATAAACTCTTAGATATTTA TATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAAAGATGTATGATTTCTAAGGCTTTAAAAATTATTCATAAAACAGTGGGCA ATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAGGGTAGTTTCAAAGCTATATATATTTTGAAGGATATATTCTTTATGAACA AATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTGTGGGATTAATATGGTCGAAAACAAATGTTATGGAGAAGCTGTCCCAAGC AAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGAGGCAACCACATGAAGCAATACTTCTTACACATGCCTAAGAACGTTCATT GAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCACCAATACTTTTGAAAAATTGTGAACCTTACCCAAAACCATTTATCATGTC CATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACATGTTCCATCTCCACAGTGGAAAAACTTATTGAGGCTACCAAAGTGTGCC AAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTCCTCAAAAGCATGAGAAACTAGCATTTTCATTTCTTATTTACTCCCTTTC TATATCAATGCAATTCACAACCCAATTTTAATACATCCCTATATCTCAAGCATTTCTATCTTGTACTTTTTCAGAAAATAAACCAAAAAT AATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACAGAAATGTAAAAACAGAAGGGGTCCAATTTTTACACGTTTTTTTCTCAAG TAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAATCAGCTTTTCAAAATGTTTTCTATTTCTCAGCATTTCCAGGAAGTGATA ACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATATTGTTACCTTGTCTAGCCTTAGGAAGAAAACAAGAGCCACCTGAAAATA AATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACAGCAATTTGAAGTTGATGTGGTAGGAAAGGAAGGTGACTTTTCTTGCAAA AGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTTCTTGTTTTATTCCGGTATATTCCACAAGGTGGCACTTTTAGAGAAAAAC AAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTTCATTCTAACTTTATTTTTCTGCGCATATTTAACTCTTTCCTAGCACTTG TTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACTTCAATATTTTACTTGTTACCTAGGTTCTGAACAATTGTCTGCAAATAAA TTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTAAGTAAAGAAAGCCTAGTCATTCATTCAGTCAAGAAAAAATTTTTGAAGT ACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTTACTAAAAAGGCAGTCCTCATCTGTGAACAGGATAGTTTCGTTAGAAGTA TAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCTCTCTGCTGCTTTCAAATTCCCTAGCATGGTGGCCTTTCAACATTGATTA AATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGAGTAGCACATCAGTAATTCAGTAGACAAAACTTTTGTCTGAAAAATTGCT GTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAATTTTAACATTTGTGGAATCACAAATGTAAATTCATAAGAAGCTCTAATTA AAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGAGTGTGTCTACATACTTAACTTTTGAAGTTTTTTGGCAACTTTATATACT TTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCCCAAATGATTAAGTTAATTTTAGAGGTCACCTTTCTCACAGCAGTGTCAC TTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTTTCCTTAGCACAGCACCACAGAAAGCAGCTTATTCCTTTTGAGTGGCAGA CACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAGCAGATGAGTCTCAGTAATTCATACTGAACCAAAATGCCACATACACTAG GGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCGCCCCTCTGCTCCCAGGAACTAGAGTCCAGTTAAAGCCCCTATGCGAAAG GCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTCTGAACCCCATTTGCTCGTGCTCAAAACTTGATTCCCACTTGAAAGCCTT CCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGAGAGGCAGTGGGCGAGGCCGGGCTGGGGCCCCGCCTCCCACTCACCTGCC GGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGAGGTCAGAGTGCCCTGCTGCTGTCTCAGAGGCATCTGTTCTGCAAATCTT AGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGTGCATAAATAAGTACAACACAATTCTCCGAAAGTTCGGGTAAAAAGAGAT GCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATCTCTCAGGCGCTAAGCTCAGTTTTTGTTTTTGTTTTTGTTTTTTTAAAGA AAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATTTTCCATCATTCTATATATGTGATGGTGAAAGATATGCCTGGAAAAGTTT TGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCAAAAGCTCTCAATTCTTTAGCTTCCAGTTTCTTTTCTCTCTTTTTCTTTG TTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGCAGGGGATTTTCATGTTGAGAGGAATCTTCCGTGTGAGTTGTTTGGTCAC ACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAAATGTAGGTTTTTCTCAAAGGGGGCATATAACTACATATTGACTGCCAAG AACTATGACTGTAGCACTAATCAGCACACATAGAGCCACACAATTATTTAATTTCTAACTCTCTGTGGTCCCTAGAAAAATTCCGTTGAT GTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTACTTGAAAGTTTCTAATCTTAAGTTTTATGAAATGCAATAATATGTATCA GCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGATCTTAAAGTCTGAATAATAAAACAAATCCCAGCAGTAATACATTTCTTA AACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGTGTTTGCAAAAATATACACATGTATATCATAGTTCCTCACTTTTTATTCA TTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTACATGGAATTTATAGCATCAGCTACCCCCAGGAACAGCACCTGACAGGCGG GGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATTTCTATTATTATTCATGTATGTTATTTATTTCTGAATCACACTAGTCCTG TGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCATCTAATGTTCATTATCATGGTATTGATGGACCTAAGAAAATAAAAATTAG ACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATTAGTAGATTTGAATATATAGATGTAGTATTTTGGGTATCTAGGTGTTTTA TCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGTTTTTATTAAATATGCATATAGTAGAGTGCAAAAATATAGCAAAAATAAA AACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAGAAACTGTGCCAGGTGGCCCTCGGAATAGATGCCAGGCAGAGACCAGTGC CTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTTCCCTCACGTGATGTAGTGCCCTCGTAGGTGTCATGTGGAGTAGTGGGAA CAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTCTGTAGAAGCAGAACTGTCAGCTTGTGCCTTGAGGCTTCCAGAACGTGTC AGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGCTGTGTACAGAAGCAATCCAGTGTGGTAATAAAAAGCAAGGATTGCCTGT ATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAATTCCCAACACCTCAAAAGCTTGTTGCATTTTTTGGTATTTGAGGTTTTT ATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAGTATGTGTTAAGAAAAGAAAAATATTGGTTCACGTAGAGTGCAAATTAGA ACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAAAGTAGGTTTTCACTGTAAAATGTATTAGTGTTTCTGCATTGCCATAGGG CCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCACATACAGTAAGCTTTTTTCCTTCTGACTTATAATAGAAAATGTTTTGAAA GTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGTTTCTGTGTTTGAAATCATGGTTCTAGAAATGTAGAAATTGTGTATATCA GATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAACATCCCCACACCTCTACATCTCTGTCCCCTGTATCTCTTCCTTTCTACC ACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGGTGCTCTCCATCTTCCTCCACATCATGGACCACAGGTGTGCCTGTCTAGG CCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTAGAGATGGTTCCTGATGCTGGGCACAGACTGTGCTCATGGCACCCATTAG AAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAACCAAGTCATTGTACAGAGCATTCAGTTTTGGCTGTGGTACCAAGAGAAAA ACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTCTCTCCATCTACAGGCCACACTTTTACTGTATTTCTTCATACTTGAAATT CATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGTGCATGTTCCTTAAAGGTGCATAATTATTCTTATTCCGTTTGCTTATATT GCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGACCCAAGAAGCAGTGTGGAAATTCACTGCCTGGGACACAGTCTTATAAGAA TGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTCTCTGTACACAGATTGAGAGTTACCACAGTGGCCTGTCGGGTCCACCCTG TGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACCTATTCTAACGTTTTTGCCCTCTAAGAAAAATGGCCTCAGGTATGGTATA GACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCATCCCTCCATTACACACAGAAAGCCCTCTTGAAGCAAAAGAAGAAGAAAG AAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTCTGAGCTGAATGCTCTTGCTCCTTTCCCAAGAGGCAGATGAAAATATAGC CAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAAAAGTAGGGTAAATATGTAACGTAAAATATGTCATTCAAGGACCACCAAA ACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTAGCTCAAGTAAGGGATGCTTTGTGACCCAGGGTTTCTGAAGTCAGATAGC CATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGAGAACTGCAGTGGTGTTTCTGTTGCAGTGGCAAAGGTAACATGTCAGAAA ATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGATGTCTTACTGGGTGCTAGAATGAAAATGTAGGTATTTATTGTCAGATGAT GAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCACTGTCCAATGTGTTCACTTATGTGAAAGCTAAATTGAATGAGGCAAAAAG AGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTTACAATAAAAATATTGGTAGCAAATAAAAATAATAAAAACAATAACTTTA AACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCTTTTTTACTTTAATGTAAAATGAGTATAACTGTAGTGAGTAAAATTCATT >43461_43461_1_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394503_CDK6_chr7_92247521_ENST00000265734_length(amino acids)=155AA_BP= MNQNATYTRGSQKLAEKSPASFAPLLPGTRVQLKPLCERPNSTPGFVITVASLNPICSCSKLDSHLKAFRARCLVAPPLWQERGSGRGRA -------------------------------------------------------------- >43461_43461_2_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394503_CDK6_chr7_92247521_ENST00000424848_length(transcript)=782nt_BP=499nt ATAGCCACGGTAACGGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCT GAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTC ATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACG CTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAA CCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAA GAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATG TTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTAC TTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCA >43461_43461_2_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394503_CDK6_chr7_92247521_ENST00000424848_length(amino acids)=120AA_BP=26 MHMLLLFVQRILPVSILGNTELSHMNVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH -------------------------------------------------------------- >43461_43461_3_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394507_CDK6_chr7_92247521_ENST00000265734_length(transcript)=11388nt_BP=886nt GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGA AAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGC GATTTCATAGCCACGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCT CGGTGTCCTTCGGGAAACAGGAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCC CCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCT CATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAA CCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATC CCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAG AAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGA TGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCC CAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAG ATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACC CATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGAG GCCTCAGCAGCCGCCTTAAGCTGATCCTGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCAAGCCCTACAGAGCTGTGGAGGA TTGCTATCTGGAGGCCTTCCAGCTGCTGTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAGTTTACTGTTTTGAAATCAATGC AAGAGTGATTGCAGCTTTATGTTCATTTGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAATTCCAGAAGAAGAGAAGCTGCT GACCAATTGTGCTGCCATTTGATTTTTCTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGCACAGCTGAGTTATGATGTAATC TCTCTGCAGCTGCCGGGCCTGATTTGGTACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGA GATTCTGTGATCTTTTAAAGTGTTACTTTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAGGTGGTCAGTAAATAACAGGCAT TTGTTCACTGAAGGTGATTCACCAAAATAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCATTTCTTTTCTGGCCAAAAGCAG TAAATTTGCTAGCAGTAAAAGATGAAGTTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATATTTTAAGAGATGTGCATGCATTC TATTTAGTCTTCAGAATGCTGAATTTACTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGCTTTATCATTTCTTTTGGAAAAT AGCCTGTAAGCTTTTTATTACTTGCTATAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAGAATAGAAAGCCTTTATTTCCTG GTTTGAAATTCCTTTCTTCCCTTTTTTTGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTGTTTTTAGGAATTTGTCAGAAAC TCTTTCCTGTTTTGGTTTGGAGAGTAGTTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCTCATCTATTACACTGTACTTTCT GCCACACACTGCCTTGTTGGCAAAGTATCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCTACCATTGTATAACTAATAACAG ATTGCTTAAGCTGTTCCCATGCACCACCTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGTCTCAGCTTATGGTTTATGGCCT CGATTCTGCAAACCTAACAGGGTCACATATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTTGTTACCTAAATAATGAGTAGGA TCTTGTTTTGTTTTATCACCAGCACACAGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATAGAAGATATTTTCAGTGTCTTTA CCTGAGGGTATGTCTTTAGCTATGTTTTAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCATCCCCCAGGCTGTGCTTATTTCT AGTGCCTTGTGCTCACTCCTGCTCTCTACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCTTTTTCTCTTACTGTTTTCTCTA CAGTCCTTTATATTTCATACCATCTCTGCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCAGAGGACACAGAAAGTATCTTTT GGAAAGTTTAGCCACCTGTGCTTTCTGACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGATTATGTTTAGGGTTAGGATTTT CAAAGAATGGAGGTTGCTGCACTCAGAAAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTGAATTCTTTGCAGCTTAATGTGA TATATGACTATCTTGAACAAGAGAAAAAACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGAACTATTCTTTTTTAATTGCTGT ACTACTTAACATTGTTCTAATTCAGTAGCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATAAAGGAGATGGGCCATACAAATG TTTTCTACTTTCGTTGTGACAACATTGATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGAATCCACAGCATTCAAGGTCAGG TCTACTCAAAGTCTCACATGGAAAAGTGAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGACATTTTTGCTAGGGCCTACAAA TTGAATTTAAAAACTCACTGCACTGATTCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAACATAGCTTTAGTTTTTGCTGTTG TAAAAGTGTTTTCATAAGTTCACTCAAGAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCTTTAGAATTTTAAATGAGTAGAG AGCTCAACTTTTATTCCTAGCATCTGCTTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAAAGCACAAACATTCTGGCATTCA ATCGTTGGCAGATTATCTTCTGATGACACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAAAATCTGTCCCCAGTTCTTCCAT CGGTGTAGTTGTTGCATTTGAGTGAATACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTTCTGAAATCCAGATCCAACACAA GCAGTCTTGCCGTTAGGGCATTTTGAAGCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCTTCTGTAACATATGGTTTCAAAC ATCTTTGCCAAAAGCTAAGCAGTGGTGAACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAGCTCATAGCAAGTTAAAATATTG TGACAGATTTGAAATCATGTTTGAATTTCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTGTTTGATGTTTGGTTCTGGCGGC TCAGGCATTTTGGGAACTGTTGCACAGGGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAGAAACTTGTCCATTTAGCTTTCA TAAGAAATCCCATGGCAAAGGGTAATAAAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGTAAGAACCCAGTGGGTTGGAGCC TCCCACTTTGTCCCTCCTTTGAAGTGGATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGCTTGGGGCCATTTCAGCCCCCTG TATTCTCATGATTTTCTCTCAGGAAGCACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGACTTACTAAAAATAGTTGAAAAT TATTCACCTAAGAATAGAATCTCAGCATTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATGTTCCTATCTTAAATAAAGCATG TTTCTTTTCTATAGAGAAATGTATAGTTTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACTCTTAAATAGTACCAAACATTTT GAACTTTAAATTATGTATTTAAAGTGAGTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCCTATTAAAGTCAGTAATGGCCAT TATTGTTCCATTGTGGAAATTAAATTATGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTAAAATATTGCTTTTCTTTTAAGT GACAATTTGACTATTCTTATGATAAGCACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATTGCATAGTTGAGTCTAGGAAAAA ATAATGTTAAAAGTGAATATGCCACCATAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTTACCCTGGAAAGAAAATATTGGA ATGTTATTATAAACTCTTAGATATTTATATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAAAGATGTATGATTTCTAAGGCTT TAAAAATTATTCATAAAACAGTGGGCAATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAGGGTAGTTTCAAAGCTATATATA TTTTGAAGGATATATTCTTTATGAACAAATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTGTGGGATTAATATGGTCGAAAAC AAATGTTATGGAGAAGCTGTCCCAAGCAAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGAGGCAACCACATGAAGCAATACT TCTTACACATGCCTAAGAACGTTCATTGAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCACCAATACTTTTGAAAAATTGTGA ACCTTACCCAAAACCATTTATCATGTCCATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACATGTTCCATCTCCACAGTGGAAA AACTTATTGAGGCTACCAAAGTGTGCCAAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTCCTCAAAAGCATGAGAAACTAGC ATTTTCATTTCTTATTTACTCCCTTTCTATATCAATGCAATTCACAACCCAATTTTAATACATCCCTATATCTCAAGCATTTCTATCTTG TACTTTTTCAGAAAATAAACCAAAAATAATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACAGAAATGTAAAAACAGAAGGGGT CCAATTTTTACACGTTTTTTTCTCAAGTAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAATCAGCTTTTCAAAATGTTTTCT ATTTCTCAGCATTTCCAGGAAGTGATAACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATATTGTTACCTTGTCTAGCCTTAG GAAGAAAACAAGAGCCACCTGAAAATAAATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACAGCAATTTGAAGTTGATGTGGTA GGAAAGGAAGGTGACTTTTCTTGCAAAAGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTTCTTGTTTTATTCCGGTATATTC CACAAGGTGGCACTTTTAGAGAAAAACAAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTTCATTCTAACTTTATTTTTCTGC GCATATTTAACTCTTTCCTAGCACTTGTTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACTTCAATATTTTACTTGTTACCTA GGTTCTGAACAATTGTCTGCAAATAAATTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTAAGTAAAGAAAGCCTAGTCATTC ATTCAGTCAAGAAAAAATTTTTGAAGTACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTTACTAAAAAGGCAGTCCTCATCT GTGAACAGGATAGTTTCGTTAGAAGTATAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCTCTCTGCTGCTTTCAAATTCCCT AGCATGGTGGCCTTTCAACATTGATTAAATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGAGTAGCACATCAGTAATTCAGTA GACAAAACTTTTGTCTGAAAAATTGCTGTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAATTTTAACATTTGTGGAATCACAA ATGTAAATTCATAAGAAGCTCTAATTAAAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGAGTGTGTCTACATACTTAACTTT TGAAGTTTTTTGGCAACTTTATATACTTTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCCCAAATGATTAAGTTAATTTTAG AGGTCACCTTTCTCACAGCAGTGTCACTTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTTTCCTTAGCACAGCACCACAGAA AGCAGCTTATTCCTTTTGAGTGGCAGACACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAGCAGATGAGTCTCAGTAATTCAT ACTGAACCAAAATGCCACATACACTAGGGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCGCCCCTCTGCTCCCAGGAACTAG AGTCCAGTTAAAGCCCCTATGCGAAAGGCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTCTGAACCCCATTTGCTCGTGCTC AAAACTTGATTCCCACTTGAAAGCCTTCCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGAGAGGCAGTGGGCGAGGCCGGGC TGGGGCCCCGCCTCCCACTCACCTGCCGGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGAGGTCAGAGTGCCCTGCTGCTGT CTCAGAGGCATCTGTTCTGCAAATCTTAGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGTGCATAAATAAGTACAACACAAT TCTCCGAAAGTTCGGGTAAAAAGAGATGCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATCTCTCAGGCGCTAAGCTCAGTTT TTGTTTTTGTTTTTGTTTTTTTAAAGAAAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATTTTCCATCATTCTATATATGTGA TGGTGAAAGATATGCCTGGAAAAGTTTTGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCAAAAGCTCTCAATTCTTTAGCTT CCAGTTTCTTTTCTCTCTTTTTCTTTGTTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGCAGGGGATTTTCATGTTGAGAGG AATCTTCCGTGTGAGTTGTTTGGTCACACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAAATGTAGGTTTTTCTCAAAGGGG GCATATAACTACATATTGACTGCCAAGAACTATGACTGTAGCACTAATCAGCACACATAGAGCCACACAATTATTTAATTTCTAACTCTC TGTGGTCCCTAGAAAAATTCCGTTGATGTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTACTTGAAAGTTTCTAATCTTAAG TTTTATGAAATGCAATAATATGTATCAGCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGATCTTAAAGTCTGAATAATAAAA CAAATCCCAGCAGTAATACATTTCTTAAACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGTGTTTGCAAAAATATACACATGT ATATCATAGTTCCTCACTTTTTATTCATTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTACATGGAATTTATAGCATCAGCTA CCCCCAGGAACAGCACCTGACAGGCGGGGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATTTCTATTATTATTCATGTATGTT ATTTATTTCTGAATCACACTAGTCCTGTGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCATCTAATGTTCATTATCATGGTAT TGATGGACCTAAGAAAATAAAAATTAGACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATTAGTAGATTTGAATATATAGATG TAGTATTTTGGGTATCTAGGTGTTTTATCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGTTTTTATTAAATATGCATATAGT AGAGTGCAAAAATATAGCAAAAATAAAAACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAGAAACTGTGCCAGGTGGCCCTCG GAATAGATGCCAGGCAGAGACCAGTGCCTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTTCCCTCACGTGATGTAGTGCCCT CGTAGGTGTCATGTGGAGTAGTGGGAACAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTCTGTAGAAGCAGAACTGTCAGCT TGTGCCTTGAGGCTTCCAGAACGTGTCAGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGCTGTGTACAGAAGCAATCCAGTG TGGTAATAAAAAGCAAGGATTGCCTGTATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAATTCCCAACACCTCAAAAGCTTG TTGCATTTTTTGGTATTTGAGGTTTTTATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAGTATGTGTTAAGAAAAGAAAAAT ATTGGTTCACGTAGAGTGCAAATTAGAACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAAAGTAGGTTTTCACTGTAAAATG TATTAGTGTTTCTGCATTGCCATAGGGCCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCACATACAGTAAGCTTTTTTCCTTC TGACTTATAATAGAAAATGTTTTGAAAGTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGTTTCTGTGTTTGAAATCATGGTT CTAGAAATGTAGAAATTGTGTATATCAGATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAACATCCCCACACCTCTACATCTC TGTCCCCTGTATCTCTTCCTTTCTACCACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGGTGCTCTCCATCTTCCTCCACAT CATGGACCACAGGTGTGCCTGTCTAGGCCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTAGAGATGGTTCCTGATGCTGGGC ACAGACTGTGCTCATGGCACCCATTAGAAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAACCAAGTCATTGTACAGAGCATTC AGTTTTGGCTGTGGTACCAAGAGAAAAACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTCTCTCCATCTACAGGCCACACTT TTACTGTATTTCTTCATACTTGAAATTCATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGTGCATGTTCCTTAAAGGTGCATA ATTATTCTTATTCCGTTTGCTTATATTGCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGACCCAAGAAGCAGTGTGGAAATTC ACTGCCTGGGACACAGTCTTATAAGAATGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTCTCTGTACACAGATTGAGAGTTA CCACAGTGGCCTGTCGGGTCCACCCTGTGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACCTATTCTAACGTTTTTGCCCTCT AAGAAAAATGGCCTCAGGTATGGTATAGACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCATCCCTCCATTACACACAGAAAG CCCTCTTGAAGCAAAAGAAGAAGAAAGAAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTCTGAGCTGAATGCTCTTGCTCCT TTCCCAAGAGGCAGATGAAAATATAGCCAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAAAAGTAGGGTAAATATGTAACGT AAAATATGTCATTCAAGGACCACCAAAACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTAGCTCAAGTAAGGGATGCTTTGT GACCCAGGGTTTCTGAAGTCAGATAGCCATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGAGAACTGCAGTGGTGTTTCTGTT GCAGTGGCAAAGGTAACATGTCAGAAAATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGATGTCTTACTGGGTGCTAGAATGA AAATGTAGGTATTTATTGTCAGATGATGAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCACTGTCCAATGTGTTCACTTATGT GAAAGCTAAATTGAATGAGGCAAAAAGAGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTTACAATAAAAATATTGGTAGCAA ATAAAAATAATAAAAACAATAACTTTAAACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCTTTTTTACTTTAATGTAAAATGA >43461_43461_3_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394507_CDK6_chr7_92247521_ENST00000265734_length(amino acids)=155AA_BP= MNQNATYTRGSQKLAEKSPASFAPLLPGTRVQLKPLCERPNSTPGFVITVASLNPICSCSKLDSHLKAFRARCLVAPPLWQERGSGRGRA -------------------------------------------------------------- >43461_43461_4_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394507_CDK6_chr7_92247521_ENST00000424848_length(transcript)=1169nt_BP=886nt GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGA AAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGC GATTTCATAGCCACGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCT CGGTGTCCTTCGGGAAACAGGAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCC CCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCT CATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAA CCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATC CCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAG AAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGA TGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCC CAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAG ATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACC >43461_43461_4_KRIT1-CDK6_KRIT1_chr7_91871347_ENST00000394507_CDK6_chr7_92247521_ENST00000424848_length(amino acids)=120AA_BP=26 MHMLLLFVQRILPVSILGNTELSHMNVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH -------------------------------------------------------------- >43461_43461_5_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394503_CDK6_chr7_92247521_ENST00000265734_length(transcript)=11001nt_BP=499nt ATAGCCACGGTAACGGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCT GAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTC ATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACG CTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAA CCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAA GAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATG TTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTAC TTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCA AAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGAGGCCTCAGCAGCCGCCTTAAGCTGATCC TGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCAAGCCCTACAGAGCTGTGGAGGATTGCTATCTGGAGGCCTTCCAGCTGCT GTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAGTTTACTGTTTTGAAATCAATGCAAGAGTGATTGCAGCTTTATGTTCATT TGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAATTCCAGAAGAAGAGAAGCTGCTGACCAATTGTGCTGCCATTTGATTTTT CTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGCACAGCTGAGTTATGATGTAATCTCTCTGCAGCTGCCGGGCCTGATTTGG TACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGAGATTCTGTGATCTTTTAAAGTGTTACT TTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAGGTGGTCAGTAAATAACAGGCATTTGTTCACTGAAGGTGATTCACCAAAA TAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCATTTCTTTTCTGGCCAAAAGCAGTAAATTTGCTAGCAGTAAAAGATGAAG TTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATATTTTAAGAGATGTGCATGCATTCTATTTAGTCTTCAGAATGCTGAATTTA CTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGCTTTATCATTTCTTTTGGAAAATAGCCTGTAAGCTTTTTATTACTTGCTA TAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAGAATAGAAAGCCTTTATTTCCTGGTTTGAAATTCCTTTCTTCCCTTTTTT TGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTGTTTTTAGGAATTTGTCAGAAACTCTTTCCTGTTTTGGTTTGGAGAGTAG TTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCTCATCTATTACACTGTACTTTCTGCCACACACTGCCTTGTTGGCAAAGTA TCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCTACCATTGTATAACTAATAACAGATTGCTTAAGCTGTTCCCATGCACCAC CTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGTCTCAGCTTATGGTTTATGGCCTCGATTCTGCAAACCTAACAGGGTCACA TATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTTGTTACCTAAATAATGAGTAGGATCTTGTTTTGTTTTATCACCAGCACAC AGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATAGAAGATATTTTCAGTGTCTTTACCTGAGGGTATGTCTTTAGCTATGTTT TAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCATCCCCCAGGCTGTGCTTATTTCTAGTGCCTTGTGCTCACTCCTGCTCTCT ACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCTTTTTCTCTTACTGTTTTCTCTACAGTCCTTTATATTTCATACCATCTCT GCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCAGAGGACACAGAAAGTATCTTTTGGAAAGTTTAGCCACCTGTGCTTTCTG ACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGATTATGTTTAGGGTTAGGATTTTCAAAGAATGGAGGTTGCTGCACTCAGA AAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTGAATTCTTTGCAGCTTAATGTGATATATGACTATCTTGAACAAGAGAAAA AACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGAACTATTCTTTTTTAATTGCTGTACTACTTAACATTGTTCTAATTCAGTA GCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATAAAGGAGATGGGCCATACAAATGTTTTCTACTTTCGTTGTGACAACATTG ATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGAATCCACAGCATTCAAGGTCAGGTCTACTCAAAGTCTCACATGGAAAAGT GAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGACATTTTTGCTAGGGCCTACAAATTGAATTTAAAAACTCACTGCACTGAT TCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAACATAGCTTTAGTTTTTGCTGTTGTAAAAGTGTTTTCATAAGTTCACTCAA GAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCTTTAGAATTTTAAATGAGTAGAGAGCTCAACTTTTATTCCTAGCATCTGC TTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAAAGCACAAACATTCTGGCATTCAATCGTTGGCAGATTATCTTCTGATGAC ACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAAAATCTGTCCCCAGTTCTTCCATCGGTGTAGTTGTTGCATTTGAGTGAAT ACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTTCTGAAATCCAGATCCAACACAAGCAGTCTTGCCGTTAGGGCATTTTGAA GCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCTTCTGTAACATATGGTTTCAAACATCTTTGCCAAAAGCTAAGCAGTGGTG AACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAGCTCATAGCAAGTTAAAATATTGTGACAGATTTGAAATCATGTTTGAATT TCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTGTTTGATGTTTGGTTCTGGCGGCTCAGGCATTTTGGGAACTGTTGCACAG GGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAGAAACTTGTCCATTTAGCTTTCATAAGAAATCCCATGGCAAAGGGTAATA AAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGTAAGAACCCAGTGGGTTGGAGCCTCCCACTTTGTCCCTCCTTTGAAGTGG ATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGCTTGGGGCCATTTCAGCCCCCTGTATTCTCATGATTTTCTCTCAGGAAGC ACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGACTTACTAAAAATAGTTGAAAATTATTCACCTAAGAATAGAATCTCAGCA TTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATGTTCCTATCTTAAATAAAGCATGTTTCTTTTCTATAGAGAAATGTATAGT TTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACTCTTAAATAGTACCAAACATTTTGAACTTTAAATTATGTATTTAAAGTGA GTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCCTATTAAAGTCAGTAATGGCCATTATTGTTCCATTGTGGAAATTAAATTA TGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTAAAATATTGCTTTTCTTTTAAGTGACAATTTGACTATTCTTATGATAAGC ACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATTGCATAGTTGAGTCTAGGAAAAAATAATGTTAAAAGTGAATATGCCACCA TAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTTACCCTGGAAAGAAAATATTGGAATGTTATTATAAACTCTTAGATATTTA TATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAAAGATGTATGATTTCTAAGGCTTTAAAAATTATTCATAAAACAGTGGGCA ATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAGGGTAGTTTCAAAGCTATATATATTTTGAAGGATATATTCTTTATGAACA AATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTGTGGGATTAATATGGTCGAAAACAAATGTTATGGAGAAGCTGTCCCAAGC AAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGAGGCAACCACATGAAGCAATACTTCTTACACATGCCTAAGAACGTTCATT GAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCACCAATACTTTTGAAAAATTGTGAACCTTACCCAAAACCATTTATCATGTC CATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACATGTTCCATCTCCACAGTGGAAAAACTTATTGAGGCTACCAAAGTGTGCC AAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTCCTCAAAAGCATGAGAAACTAGCATTTTCATTTCTTATTTACTCCCTTTC TATATCAATGCAATTCACAACCCAATTTTAATACATCCCTATATCTCAAGCATTTCTATCTTGTACTTTTTCAGAAAATAAACCAAAAAT AATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACAGAAATGTAAAAACAGAAGGGGTCCAATTTTTACACGTTTTTTTCTCAAG TAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAATCAGCTTTTCAAAATGTTTTCTATTTCTCAGCATTTCCAGGAAGTGATA ACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATATTGTTACCTTGTCTAGCCTTAGGAAGAAAACAAGAGCCACCTGAAAATA AATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACAGCAATTTGAAGTTGATGTGGTAGGAAAGGAAGGTGACTTTTCTTGCAAA AGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTTCTTGTTTTATTCCGGTATATTCCACAAGGTGGCACTTTTAGAGAAAAAC AAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTTCATTCTAACTTTATTTTTCTGCGCATATTTAACTCTTTCCTAGCACTTG TTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACTTCAATATTTTACTTGTTACCTAGGTTCTGAACAATTGTCTGCAAATAAA TTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTAAGTAAAGAAAGCCTAGTCATTCATTCAGTCAAGAAAAAATTTTTGAAGT ACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTTACTAAAAAGGCAGTCCTCATCTGTGAACAGGATAGTTTCGTTAGAAGTA TAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCTCTCTGCTGCTTTCAAATTCCCTAGCATGGTGGCCTTTCAACATTGATTA AATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGAGTAGCACATCAGTAATTCAGTAGACAAAACTTTTGTCTGAAAAATTGCT GTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAATTTTAACATTTGTGGAATCACAAATGTAAATTCATAAGAAGCTCTAATTA AAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGAGTGTGTCTACATACTTAACTTTTGAAGTTTTTTGGCAACTTTATATACT TTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCCCAAATGATTAAGTTAATTTTAGAGGTCACCTTTCTCACAGCAGTGTCAC TTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTTTCCTTAGCACAGCACCACAGAAAGCAGCTTATTCCTTTTGAGTGGCAGA CACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAGCAGATGAGTCTCAGTAATTCATACTGAACCAAAATGCCACATACACTAG GGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCGCCCCTCTGCTCCCAGGAACTAGAGTCCAGTTAAAGCCCCTATGCGAAAG GCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTCTGAACCCCATTTGCTCGTGCTCAAAACTTGATTCCCACTTGAAAGCCTT CCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGAGAGGCAGTGGGCGAGGCCGGGCTGGGGCCCCGCCTCCCACTCACCTGCC GGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGAGGTCAGAGTGCCCTGCTGCTGTCTCAGAGGCATCTGTTCTGCAAATCTT AGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGTGCATAAATAAGTACAACACAATTCTCCGAAAGTTCGGGTAAAAAGAGAT GCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATCTCTCAGGCGCTAAGCTCAGTTTTTGTTTTTGTTTTTGTTTTTTTAAAGA AAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATTTTCCATCATTCTATATATGTGATGGTGAAAGATATGCCTGGAAAAGTTT TGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCAAAAGCTCTCAATTCTTTAGCTTCCAGTTTCTTTTCTCTCTTTTTCTTTG TTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGCAGGGGATTTTCATGTTGAGAGGAATCTTCCGTGTGAGTTGTTTGGTCAC ACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAAATGTAGGTTTTTCTCAAAGGGGGCATATAACTACATATTGACTGCCAAG AACTATGACTGTAGCACTAATCAGCACACATAGAGCCACACAATTATTTAATTTCTAACTCTCTGTGGTCCCTAGAAAAATTCCGTTGAT GTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTACTTGAAAGTTTCTAATCTTAAGTTTTATGAAATGCAATAATATGTATCA GCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGATCTTAAAGTCTGAATAATAAAACAAATCCCAGCAGTAATACATTTCTTA AACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGTGTTTGCAAAAATATACACATGTATATCATAGTTCCTCACTTTTTATTCA TTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTACATGGAATTTATAGCATCAGCTACCCCCAGGAACAGCACCTGACAGGCGG GGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATTTCTATTATTATTCATGTATGTTATTTATTTCTGAATCACACTAGTCCTG TGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCATCTAATGTTCATTATCATGGTATTGATGGACCTAAGAAAATAAAAATTAG ACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATTAGTAGATTTGAATATATAGATGTAGTATTTTGGGTATCTAGGTGTTTTA TCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGTTTTTATTAAATATGCATATAGTAGAGTGCAAAAATATAGCAAAAATAAA AACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAGAAACTGTGCCAGGTGGCCCTCGGAATAGATGCCAGGCAGAGACCAGTGC CTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTTCCCTCACGTGATGTAGTGCCCTCGTAGGTGTCATGTGGAGTAGTGGGAA CAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTCTGTAGAAGCAGAACTGTCAGCTTGTGCCTTGAGGCTTCCAGAACGTGTC AGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGCTGTGTACAGAAGCAATCCAGTGTGGTAATAAAAAGCAAGGATTGCCTGT ATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAATTCCCAACACCTCAAAAGCTTGTTGCATTTTTTGGTATTTGAGGTTTTT ATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAGTATGTGTTAAGAAAAGAAAAATATTGGTTCACGTAGAGTGCAAATTAGA ACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAAAGTAGGTTTTCACTGTAAAATGTATTAGTGTTTCTGCATTGCCATAGGG CCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCACATACAGTAAGCTTTTTTCCTTCTGACTTATAATAGAAAATGTTTTGAAA GTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGTTTCTGTGTTTGAAATCATGGTTCTAGAAATGTAGAAATTGTGTATATCA GATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAACATCCCCACACCTCTACATCTCTGTCCCCTGTATCTCTTCCTTTCTACC ACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGGTGCTCTCCATCTTCCTCCACATCATGGACCACAGGTGTGCCTGTCTAGG CCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTAGAGATGGTTCCTGATGCTGGGCACAGACTGTGCTCATGGCACCCATTAG AAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAACCAAGTCATTGTACAGAGCATTCAGTTTTGGCTGTGGTACCAAGAGAAAA ACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTCTCTCCATCTACAGGCCACACTTTTACTGTATTTCTTCATACTTGAAATT CATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGTGCATGTTCCTTAAAGGTGCATAATTATTCTTATTCCGTTTGCTTATATT GCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGACCCAAGAAGCAGTGTGGAAATTCACTGCCTGGGACACAGTCTTATAAGAA TGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTCTCTGTACACAGATTGAGAGTTACCACAGTGGCCTGTCGGGTCCACCCTG TGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACCTATTCTAACGTTTTTGCCCTCTAAGAAAAATGGCCTCAGGTATGGTATA GACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCATCCCTCCATTACACACAGAAAGCCCTCTTGAAGCAAAAGAAGAAGAAAG AAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTCTGAGCTGAATGCTCTTGCTCCTTTCCCAAGAGGCAGATGAAAATATAGC CAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAAAAGTAGGGTAAATATGTAACGTAAAATATGTCATTCAAGGACCACCAAA ACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTAGCTCAAGTAAGGGATGCTTTGTGACCCAGGGTTTCTGAAGTCAGATAGC CATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGAGAACTGCAGTGGTGTTTCTGTTGCAGTGGCAAAGGTAACATGTCAGAAA ATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGATGTCTTACTGGGTGCTAGAATGAAAATGTAGGTATTTATTGTCAGATGAT GAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCACTGTCCAATGTGTTCACTTATGTGAAAGCTAAATTGAATGAGGCAAAAAG AGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTTACAATAAAAATATTGGTAGCAAATAAAAATAATAAAAACAATAACTTTA AACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCTTTTTTACTTTAATGTAAAATGAGTATAACTGTAGTGAGTAAAATTCATT >43461_43461_5_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394503_CDK6_chr7_92247521_ENST00000265734_length(amino acids)=155AA_BP= MNQNATYTRGSQKLAEKSPASFAPLLPGTRVQLKPLCERPNSTPGFVITVASLNPICSCSKLDSHLKAFRARCLVAPPLWQERGSGRGRA -------------------------------------------------------------- >43461_43461_6_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394503_CDK6_chr7_92247521_ENST00000424848_length(transcript)=782nt_BP=499nt ATAGCCACGGTAACGGCGGGGTGGAAAGCTAAGGCCTTTGAAGACCTGGGACCCCGTAGTTTCGGGAGAGGGTGAGGGGTGAATGGTGCT GAGGTGCGAGGAGAGGGAAGGACAGTAAAGAGCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTC ATCTCGGTGGTCCAACTCAGGATCTCAGCCTCATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACG CTGTCTAGCATACTAAGAGGATGTTAGCAAACCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAA CCAGAAATGCCCTCCATATTTTCCAGTGATCCCAGCAATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAA GAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCCCAGGAGAAGAAGACTGGCCTAGAGATG TTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTAC TTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTCCAGGACCTGGAAAGGTGCA >43461_43461_6_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394503_CDK6_chr7_92247521_ENST00000424848_length(amino acids)=120AA_BP=26 MHMLLLFVQRILPVSILGNTELSHMNVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH -------------------------------------------------------------- >43461_43461_7_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394507_CDK6_chr7_92247521_ENST00000265734_length(transcript)=11388nt_BP=886nt GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGA AAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGC GATTTCATAGCCACGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCT CGGTGTCCTTCGGGAAACAGGAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCC CCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCT CATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAA CCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATC CCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAG AAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGA TGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCC CAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAG ATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACC CATACTTCCAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACCTCGGAGCTGAATACAGCCTGAG GCCTCAGCAGCCGCCTTAAGCTGATCCTGCGGAGAACACCCTTGGTGGCTTATGGGTCCCCCTCAGCAAGCCCTACAGAGCTGTGGAGGA TTGCTATCTGGAGGCCTTCCAGCTGCTGTCTTCTGGACAGGCTCTGCTTCTCCAAGGAAACCGCCTAGTTTACTGTTTTGAAATCAATGC AAGAGTGATTGCAGCTTTATGTTCATTTGTTTGTTTGTTTGTCTGTTTGTTTCAAGAACCTGGAAAAATTCCAGAAGAAGAGAAGCTGCT GACCAATTGTGCTGCCATTTGATTTTTCTAACCTTGAATGCTGCCAGTGTGGAGTGGGTAATCCAGGCACAGCTGAGTTATGATGTAATC TCTCTGCAGCTGCCGGGCCTGATTTGGTACTTTTGAGTGTGTGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGAGA GATTCTGTGATCTTTTAAAGTGTTACTTTTTGTAAACGACAAGAATAATTCAATTTTAAAGACTCAAGGTGGTCAGTAAATAACAGGCAT TTGTTCACTGAAGGTGATTCACCAAAATAGTCTTCTCAAATTAGAAAGTTAACCCCATGTCCTCAGCATTTCTTTTCTGGCCAAAAGCAG TAAATTTGCTAGCAGTAAAAGATGAAGTTTTATACACACAGCAAAAAGGAGAAAAAATTCTAGTATATTTTAAGAGATGTGCATGCATTC TATTTAGTCTTCAGAATGCTGAATTTACTTGTTGTAAGTCTATTTTAACCTTCTGTATGACATCATGCTTTATCATTTCTTTTGGAAAAT AGCCTGTAAGCTTTTTATTACTTGCTATAGGTTTAGGGAGTGTACCTCAGATAGATTTTAAAAAAAAGAATAGAAAGCCTTTATTTCCTG GTTTGAAATTCCTTTCTTCCCTTTTTTTGTTGTTGTTATTGTTGTTTGTTGTTGTTATTTTGTTTTTGTTTTTAGGAATTTGTCAGAAAC TCTTTCCTGTTTTGGTTTGGAGAGTAGTTCTCTCTAACTAGAGACAGGAGTGGCCTTGAAATTTTCCTCATCTATTACACTGTACTTTCT GCCACACACTGCCTTGTTGGCAAAGTATCCATCTTGTCTATCTCCCGGCACTTCTGAAATATATTGCTACCATTGTATAACTAATAACAG ATTGCTTAAGCTGTTCCCATGCACCACCTGTTTGCTTGCTTTCAATGAACCTTTCATAAATTCGCAGTCTCAGCTTATGGTTTATGGCCT CGATTCTGCAAACCTAACAGGGTCACATATGTTCTCTAATGCAGTCCTTCTACCTGGTGTTTACTTTTGTTACCTAAATAATGAGTAGGA TCTTGTTTTGTTTTATCACCAGCACACAGATTGCTATAAACTGTTACTTTGTGAATTACATTTTTATAGAAGATATTTTCAGTGTCTTTA CCTGAGGGTATGTCTTTAGCTATGTTTTAGGGCCATACATTTACTCTATCAAATGATCTTTTCTCCATCCCCCAGGCTGTGCTTATTTCT AGTGCCTTGTGCTCACTCCTGCTCTCTACAGAGCCAGCCTGGCCTGGGCATTGTAAACAGCTTTTCCTTTTTCTCTTACTGTTTTCTCTA CAGTCCTTTATATTTCATACCATCTCTGCCTTATAAGTGGTTTAGTGCTCAGTTGGCTCTAGTAACCAGAGGACACAGAAAGTATCTTTT GGAAAGTTTAGCCACCTGTGCTTTCTGACTCAGAGTGCATGCAACAGTTAGATCATGCAACAGTTAGATTATGTTTAGGGTTAGGATTTT CAAAGAATGGAGGTTGCTGCACTCAGAAAATAATTCAGATCATGTTTATGCATTATTAAGTTGTACTGAATTCTTTGCAGCTTAATGTGA TATATGACTATCTTGAACAAGAGAAAAAACTAGGAGATGTTTCTCCTGAAGAGCTTTTGGGGTTGGGAACTATTCTTTTTTAATTGCTGT ACTACTTAACATTGTTCTAATTCAGTAGCTTGAGGAACAGGAACATTGTTTTCTAGAGCAAGATAATAAAGGAGATGGGCCATACAAATG TTTTCTACTTTCGTTGTGACAACATTGATTAGGTGTTGTCAGTACTATAAATGCTTGAGATATAATGAATCCACAGCATTCAAGGTCAGG TCTACTCAAAGTCTCACATGGAAAAGTGAGTTCTGCCTTTCCTTTGATCGAGGGTCAAAATACAAAGACATTTTTGCTAGGGCCTACAAA TTGAATTTAAAAACTCACTGCACTGATTCATCTGAGCTTTTTGGTTAGTATTCATGGCTAGAGTGAACATAGCTTTAGTTTTTGCTGTTG TAAAAGTGTTTTCATAAGTTCACTCAAGAAAAATGCAGCTGTTCTGAACTGGAATTTTTCAGCATTCTTTAGAATTTTAAATGAGTAGAG AGCTCAACTTTTATTCCTAGCATCTGCTTTTGACTCATTTCTAGGCAGTGCTTATGAAGAAAAATTAAAGCACAAACATTCTGGCATTCA ATCGTTGGCAGATTATCTTCTGATGACACAGAATGAAAGGGCATCTCAGCCTCTCTGAACTTTGTAAAAATCTGTCCCCAGTTCTTCCAT CGGTGTAGTTGTTGCATTTGAGTGAATACTCTCTTGATTTATGTATTTTATGTCCAGATTCGCCATTTCTGAAATCCAGATCCAACACAA GCAGTCTTGCCGTTAGGGCATTTTGAAGCAGATAGTAGAGTAAGAACTTAGTGACTACAGCTTATTCTTCTGTAACATATGGTTTCAAAC ATCTTTGCCAAAAGCTAAGCAGTGGTGAACTGAAAAGGGCATATTGCCCCAAGGTTACACTGAAGCAGCTCATAGCAAGTTAAAATATTG TGACAGATTTGAAATCATGTTTGAATTTCATAGTAGGACCAGTACAAGAATGTCCCTGCTAGTTTCTGTTTGATGTTTGGTTCTGGCGGC TCAGGCATTTTGGGAACTGTTGCACAGGGTGGAGTCAAAACAACCTACATATAAAAAGAGAAAAAGAGAAACTTGTCCATTTAGCTTTCA TAAGAAATCCCATGGCAAAGGGTAATAAAAAGGACCTAATCTTAAAAATACAATTTCTAAGCACTTGTAAGAACCCAGTGGGTTGGAGCC TCCCACTTTGTCCCTCCTTTGAAGTGGATGGGAACTCAAGGTGCAAAGAACCTGTTTTGGAAGAAAGCTTGGGGCCATTTCAGCCCCCTG TATTCTCATGATTTTCTCTCAGGAAGCACACACTGTGAATGGCAGACTTTTCATTTAGCCCCAGGTGACTTACTAAAAATAGTTGAAAAT TATTCACCTAAGAATAGAATCTCAGCATTGTGTTAAATAAAAATGAAAGCTTTAGAAGGCATGAGATGTTCCTATCTTAAATAAAGCATG TTTCTTTTCTATAGAGAAATGTATAGTTTGACTCTCCAGAATGTACTATCCATCTTGATGAGAAAACTCTTAAATAGTACCAAACATTTT GAACTTTAAATTATGTATTTAAAGTGAGTGTTTAAGAAACTGTAGCTGCTTCTTTTACAAGTGGTGCCTATTAAAGTCAGTAATGGCCAT TATTGTTCCATTGTGGAAATTAAATTATGTAAGCTTCCTAATATCATAAACATATTAAAATTCTTCTAAAATATTGCTTTTCTTTTAAGT GACAATTTGACTATTCTTATGATAAGCACATGAGAGTGTCTTACATTTTCCAAAAGCAGGCTTTAATTGCATAGTTGAGTCTAGGAAAAA ATAATGTTAAAAGTGAATATGCCACCATAATTACTTAATTATGTTAGTATAGAAACTACAGAATATTTACCCTGGAAAGAAAATATTGGA ATGTTATTATAAACTCTTAGATATTTATATAATTCAAAAGAATGCATGTTTCACATTGTGACAGATAAAGATGTATGATTTCTAAGGCTT TAAAAATTATTCATAAAACAGTGGGCAATAGATAAAGGAAATTCTGGAGAAAATGAAGGTATTTAAAGGGTAGTTTCAAAGCTATATATA TTTTGAAGGATATATTCTTTATGAACAAATATATTGTAAAAATTTATACTAAGGTCATCTGGTAACTGTGGGATTAATATGGTCGAAAAC AAATGTTATGGAGAAGCTGTCCCAAGCAAACTAAATTACCTGTACTTTTTTCCCATTTCAAGGGAAGAGGCAACCACATGAAGCAATACT TCTTACACATGCCTAAGAACGTTCATTGAAAAAATAAATTTTTAAAAGGCATGTGTTTCCTATGCCACCAATACTTTTGAAAAATTGTGA ACCTTACCCAAAACCATTTATCATGTCCATTAAGTATATTTGGGTATATAATTAGGAAGATATTTACATGTTCCATCTCCACAGTGGAAA AACTTATTGAGGCTACCAAAGTGTGCCAAGAAATGTAAGTCCTTAGAGTAATTAGAAATGCTGTTTTCCTCAAAAGCATGAGAAACTAGC ATTTTCATTTCTTATTTACTCCCTTTCTATATCAATGCAATTCACAACCCAATTTTAATACATCCCTATATCTCAAGCATTTCTATCTTG TACTTTTTCAGAAAATAAACCAAAAATAATCCTTTGGTCTCTCTATCTTCTGACCTTTGTAAGCAACAGAAATGTAAAAACAGAAGGGGT CCAATTTTTACACGTTTTTTTCTCAAGTAGCCTTTCTGGGGATTTTTATTTTCTTAATGAAGTGCCAATCAGCTTTTCAAAATGTTTTCT ATTTCTCAGCATTTCCAGGAAGTGATAACGTTTAGCTAAATGAGTAGAAGTGGACTTCCTTCAACATATTGTTACCTTGTCTAGCCTTAG GAAGAAAACAAGAGCCACCTGAAAATAAATACAGGCTCTTTTCGAGCATCTGCTGAAATACTGTTACAGCAATTTGAAGTTGATGTGGTA GGAAAGGAAGGTGACTTTTCTTGCAAAAGTCTTTCTAAACATTCACACTGTCCTAAGAGATGAGCTTTCTTGTTTTATTCCGGTATATTC CACAAGGTGGCACTTTTAGAGAAAAACAAATCTGATGAAGACTAAAGAGGTACTTCTAAAAGAGATTTCATTCTAACTTTATTTTTCTGC GCATATTTAACTCTTTCCTAGCACTTGTTTTTTGGGATGATTAATAGTCTCTATAATGTTCTGTAACTTCAATATTTTACTTGTTACCTA GGTTCTGAACAATTGTCTGCAAATAAATTGTTCTTAAGGATGGATAATACACCCATTTTGATCATTTAAGTAAAGAAAGCCTAGTCATTC ATTCAGTCAAGAAAAAATTTTTGAAGTACCCAGTTACCTTACTTTTCTAGATTAAAACAGGCTTAGTTACTAAAAAGGCAGTCCTCATCT GTGAACAGGATAGTTTCGTTAGAAGTATAAAACTCCTTTAGTGGCCCCAGTTAAAACACACATACCCTCTCTGCTGCTTTCAAATTCCCT AGCATGGTGGCCTTTCAACATTGATTAAATTTTAAAATCCTAATTTAAAGATCAGGTGAGCAAAATGAGTAGCACATCAGTAATTCAGTA GACAAAACTTTTGTCTGAAAAATTGCTGTATTGAAACAGAGCCCTAAAATACCAAAAGACCAGGTAATTTTAACATTTGTGGAATCACAA ATGTAAATTCATAAGAAGCTCTAATTAAAAAAAAAAAGTCTGAAGTATATGAGCATAACAACTTAGGAGTGTGTCTACATACTTAACTTT TGAAGTTTTTTGGCAACTTTATATACTTTTTTTAAATTTACAAGTCTACTTAAAGACTTCTTATACCCCAAATGATTAAGTTAATTTTAG AGGTCACCTTTCTCACAGCAGTGTCACTTGAAATTTAGTAGGGAAGGATATTGCAGTATTTTTCAGTTTCCTTAGCACAGCACCACAGAA AGCAGCTTATTCCTTTTGAGTGGCAGACACTCGACGGTGCCTGCCCAACTTTCCTCCTGAGTGGCAAGCAGATGAGTCTCAGTAATTCAT ACTGAACCAAAATGCCACATACACTAGGGGCAGTCAGAAACTGGCTGAGAAATCCCCCGCCTCATTCGCCCCTCTGCTCCCAGGAACTAG AGTCCAGTTAAAGCCCCTATGCGAAAGGCCGAATTCCACCCCAGGGTTTGTTATAACAGTGGCCAGTCTGAACCCCATTTGCTCGTGCTC AAAACTTGATTCCCACTTGAAAGCCTTCCGGGCGCGCTGCCTCGTTGCCCCGCCCCTTTGGCAGGAGAGAGGCAGTGGGCGAGGCCGGGC TGGGGCCCCGCCTCCCACTCACCTGCCGGTGCCTGAAATTATGTGCGGCCCCGCGGGCTGCTTTCCGAGGTCAGAGTGCCCTGCTGCTGT CTCAGAGGCATCTGTTCTGCAAATCTTAGGAAGAAAAATGTCCCTAGTAGCAAACGGGTGTCTTCTGTGCATAAATAAGTACAACACAAT TCTCCGAAAGTTCGGGTAAAAAGAGATGCGGTAGCAGCTGCCCTGTGTGAAGCTGTCTACCCCGCATCTCTCAGGCGCTAAGCTCAGTTT TTGTTTTTGTTTTTGTTTTTTTAAAGAAAAGATGTATAATTGCAGGAATTTTTTTTTATTTTTTTATTTTCCATCATTCTATATATGTGA TGGTGAAAGATATGCCTGGAAAAGTTTTGTTTTGAAAAGTTTATTTTCTGCTTCGTCTTCAGTTGGCAAAAGCTCTCAATTCTTTAGCTT CCAGTTTCTTTTCTCTCTTTTTCTTTGTTAGGTAATTAAAGGTATGTAAACAAATTATCTCATGTAGCAGGGGATTTTCATGTTGAGAGG AATCTTCCGTGTGAGTTGTTTGGTCACACAAATAACCCTTTCTCAATTTTAGGAGTTTGGATTGTCAAATGTAGGTTTTTCTCAAAGGGG GCATATAACTACATATTGACTGCCAAGAACTATGACTGTAGCACTAATCAGCACACATAGAGCCACACAATTATTTAATTTCTAACTCTC TGTGGTCCCTAGAAAAATTCCGTTGATGTGCTTAGGTTAAAGTTCTGAAGATACCCGTTGTACCCTTACTTGAAAGTTTCTAATCTTAAG TTTTATGAAATGCAATAATATGTATCAGCTAGCAATATTTCTGTGATCACCAACAACTCTCAGTTTGATCTTAAAGTCTGAATAATAAAA CAAATCCCAGCAGTAATACATTTCTTAAACCTCACAGTGCATGATATATCTTTTCATTCTGATCCTGTGTTTGCAAAAATATACACATGT ATATCATAGTTCCTCACTTTTTATTCATTTGTTTTCCTATTACCTGTAGTAAATATATTAGTTAGTACATGGAATTTATAGCATCAGCTA CCCCCAGGAACAGCACCTGACAGGCGGGGGATTTTTTTTCAAGTTGTTCTACATTTGCATAAATTATTTCTATTATTATTCATGTATGTT ATTTATTTCTGAATCACACTAGTCCTGTGAAAGTACAACTGAAGGCAGAAAGTGTTAGGATTTTGCATCTAATGTTCATTATCATGGTAT TGATGGACCTAAGAAAATAAAAATTAGACTAAGCCCCCAAATAAGCTGCATGCATTTGTAACATGATTAGTAGATTTGAATATATAGATG TAGTATTTTGGGTATCTAGGTGTTTTATCATTATGTAAAGGAATTAAAGTAAAGGACTTTGTAGTTGTTTTTATTAAATATGCATATAGT AGAGTGCAAAAATATAGCAAAAATAAAAACTAAAGGTAGAAAAGCATTTTAGATATGCCTTAATTTAGAAACTGTGCCAGGTGGCCCTCG GAATAGATGCCAGGCAGAGACCAGTGCCTGGGTGGTGCCTCCTCTTGTCTGCCCTCATGAAGAAGCTTCCCTCACGTGATGTAGTGCCCT CGTAGGTGTCATGTGGAGTAGTGGGAACAGGCAGTACTGTTGAGAGGAGAGCAGTGTGAGAGTTTTTCTGTAGAAGCAGAACTGTCAGCT TGTGCCTTGAGGCTTCCAGAACGTGTCAGATGGAGAAGTCCAAGTTTCCATGCTTCAGGCAACTTAGCTGTGTACAGAAGCAATCCAGTG TGGTAATAAAAAGCAAGGATTGCCTGTATAATTTATTATAAAATAAAAGGGATTTTAACAACCAACAATTCCCAACACCTCAAAAGCTTG TTGCATTTTTTGGTATTTGAGGTTTTTATCTGAAGGTTAAAGGGCAAGTGTTTGGTATAGAAGAGCAGTATGTGTTAAGAAAAGAAAAAT ATTGGTTCACGTAGAGTGCAAATTAGAACTAGAAAGTTTTATACGATTATCATTTTGAGATGTGTTAAAGTAGGTTTTCACTGTAAAATG TATTAGTGTTTCTGCATTGCCATAGGGCCTGGTTAAAACTTTCTCTTAGGTTTCAGGAAGACTGTCACATACAGTAAGCTTTTTTCCTTC TGACTTATAATAGAAAATGTTTTGAAAGTAAAAAAAAAAAATCTAATTTGGAAATTTGACTTGTTAGTTTCTGTGTTTGAAATCATGGTT CTAGAAATGTAGAAATTGTGTATATCAGATACTCATCTAGGCTGTGTGAACCAGCCCAAGATGACCAACATCCCCACACCTCTACATCTC TGTCCCCTGTATCTCTTCCTTTCTACCACTAAAGTGTTCCCTGCTACCATCCTGGCTTGTCCACATGGTGCTCTCCATCTTCCTCCACAT CATGGACCACAGGTGTGCCTGTCTAGGCCTGGCCACCACTCCCAACTTGACCTAGCCACATTCATCTAGAGATGGTTCCTGATGCTGGGC ACAGACTGTGCTCATGGCACCCATTAGAAATGCCTCTAGCATCTTTGTATGCATCTTGATTTTTAAACCAAGTCATTGTACAGAGCATTC AGTTTTGGCTGTGGTACCAAGAGAAAAACTAATCAAGAATATAAACCACATTCCAGGCTGCTGTTTTCTCTCCATCTACAGGCCACACTT TTACTGTATTTCTTCATACTTGAAATTCATTCTGCTATTTTCATATCAGGGTACAGACTTATAAGGGTGCATGTTCCTTAAAGGTGCATA ATTATTCTTATTCCGTTTGCTTATATTGCTACAGAATGCTCTGTTTTGGTGCTTTGAGTTCTGCAGACCCAAGAAGCAGTGTGGAAATTC ACTGCCTGGGACACAGTCTTATAAGAATGTTGGCAGGTGACTTTGTATCAGATGTTGCTTCTCTTTTCTCTGTACACAGATTGAGAGTTA CCACAGTGGCCTGTCGGGTCCACCCTGTGGGTGCAGCACAGCTCTCTGAAAGCAAGAACCTTCCTACCTATTCTAACGTTTTTGCCCTCT AAGAAAAATGGCCTCAGGTATGGTATAGACATAGCAAGAGGGGAAGGGCTGTCTCACTCTAGCAACCATCCCTCCATTACACACAGAAAG CCCTCTTGAAGCAAAAGAAGAAGAAAGAAAGAAAGCTTATCTCTAAGGCTACTGTCTTCAGAATGCTCTGAGCTGAATGCTCTTGCTCCT TTCCCAAGAGGCAGATGAAAATATAGCCAGTTTATCTATACCCTTCCTATCTGAGGAGGAGAATAGAAAAGTAGGGTAAATATGTAACGT AAAATATGTCATTCAAGGACCACCAAAACTTTAAGTACCCTATCATTAAAAATCTGGTTTTAAAAGTAGCTCAAGTAAGGGATGCTTTGT GACCCAGGGTTTCTGAAGTCAGATAGCCATTCTTACCTGCCCCTTACTCTGACTTATTGGGAAAGGGAGAACTGCAGTGGTGTTTCTGTT GCAGTGGCAAAGGTAACATGTCAGAAAATTCAGAGGGTTGCATACCAATAATCCTTTGGAAACTGGATGTCTTACTGGGTGCTAGAATGA AAATGTAGGTATTTATTGTCAGATGATGAAGTTCATTGTTTTTTTCAAAATTGGTGTTGAAATATCACTGTCCAATGTGTTCACTTATGT GAAAGCTAAATTGAATGAGGCAAAAAGAGCAAATAGTTTGTATATTTGTAATACCTTTTGTATTTCTTACAATAAAAATATTGGTAGCAA ATAAAAATAATAAAAACAATAACTTTAAACTGCTTTCTGGAGATGAATTACTCTCCTGGCTATTTTCTTTTTTACTTTAATGTAAAATGA >43461_43461_7_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394507_CDK6_chr7_92247521_ENST00000265734_length(amino acids)=155AA_BP= MNQNATYTRGSQKLAEKSPASFAPLLPGTRVQLKPLCERPNSTPGFVITVASLNPICSCSKLDSHLKAFRARCLVAPPLWQERGSGRGRA -------------------------------------------------------------- >43461_43461_8_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394507_CDK6_chr7_92247521_ENST00000424848_length(transcript)=1169nt_BP=886nt GCTCCGGCTCAGCCGCTGGCACCCCCACCGCCACCACCCTAGTCTCCTAGTCGCCTGCCACCAGCCCCTGAGAGACTGCAGGTCCAGTGA AAAGGAGCAGGAACGGCAGCAGCCCGGCCGCCGACCCGGAAGCTCTTTCACCGCCAACCGCGAGGCTGCAAAGGGTGTGAACCCGGAAGC GATTTCATAGCCACGGTGACTGTCCCACCCATTTAGTTGAATGTAGCGGCCAGAGAGGCACTCGCGGCAGCCCGTACGGGTGGGACCTCT CGGTGTCCTTCGGGAAACAGGAGGAGCAAGTTCGACTCCAGCGAGGGAAAACGGAGGTGGGAGACTGAACCATCTCCACATCTAGTTGCC CCAGGTTTTTGGCTTTCATCGCTTTTTCTACATGTTTTTAGCCTCACCAGAAGTCTTTCATCTCGGTGGTCCAACTCAGGATCTCAGCCT CATTATTTTCTTACCCTTCTGGAGTGCATATGTGCCTTTACAGTTTCTGTTTGCAAACGCTGTCTAGCATACTAAGAGGATGTTAGCAAA CCTGTTCCATGGACACTAAATGGCAGTTGTACATCTCCCCTCATCAGTCATAGTGACAACCAGAAATGCCCTCCATATTTTCCAGTGATC CCAGTCTTCAATGCGTCTGTCTCATAATTTGTAAACGTTTATTATCTTGAAGTCATTGTTAATCTGTGGTGAAAAGTAATTGCTAAATAG AAATTCTGAGAAGAAAAAGGCCTCATCCTTTTCACATGATGTAGGAAGGTCTGTTGCATGAGCAATGGGAAATCCAGAAAACATAGAAGA TGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCAATTCTCGGGAATACAGAGCTAAGTCATATGAACGTGATTGGACTCC CAGGAGAAGAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAACCAATTGAGAAGTTTGTAACAG ATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGTTTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACC >43461_43461_8_KRIT1-CDK6_KRIT1_chr7_91871348_ENST00000394507_CDK6_chr7_92247521_ENST00000424848_length(amino acids)=120AA_BP=26 MHMLLLFVQRILPVSILGNTELSHMNVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KRIT1-CDK6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 172_195 | 34.0 | 689.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 172_195 | 34.0 | 689.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 172_195 | 34.0 | 737.0 | ITGB1BP1 |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 430_452 | 34.0 | 689.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871347 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000340022 | - | 4 | 19 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394503 | - | 3 | 17 | 430_452 | 34.0 | 689.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394505 | - | 4 | 19 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000394507 | - | 5 | 20 | 430_452 | 34.0 | 737.0 | RAP1B |
| Hgene | KRIT1 | chr7:91871348 | chr7:92247521 | ENST00000412043 | - | 4 | 19 | 430_452 | 34.0 | 737.0 | RAP1B |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KRIT1-CDK6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KRIT1-CDK6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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