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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KRT13-TIMM22 (FusionGDB2 ID:43493)

Fusion Gene Summary for KRT13-TIMM22

Fusion gene summary

Fusion gene information	Fusion gene name: KRT13-TIMM22
	Fusion gene ID: 43493
		Hgene	Tgene
	Gene symbol	KRT13	TIMM22
	Gene ID	3860	29928
	Gene name	keratin 13	translocase of inner mitochondrial membrane 22
	Synonyms	CK13\|K13\|WSN2	TEX4\|TIM22
	Cytomap	17q21.2	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	keratin, type I cytoskeletal 13CK-13cytokeratin 13keratin 13, type I	mitochondrial import inner membrane translocase subunit Tim22testis-expressed protein 4testis-expressed sequence 4translocase of inner mitochondrial membrane 22 homolog
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000246635, ENST00000336861, ENST00000587544, ENST00000587118,	ENST00000327158,
Fusion gene scores	* DoF score	19 X 17 X 5=1615	2 X 2 X 2=8
	# samples	23	2
	** MAII score	log2(23/1615*10)=-2.81182839863691 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: KRT13 [Title/Abstract] AND TIMM22 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KRT13(39658938)-TIMM22(902751), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KRT13	GO:0007010	cytoskeleton organization	21371075
Tgene	TIMM22	GO:0045039	protein import into mitochondrial inner membrane	28712724\|28712726

Fusion gene breakpoints across KRT13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TIMM22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OF	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+

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Fusion Gene ORF analysis for KRT13-TIMM22

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000246635	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+
In-frame	ENST00000336861	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+
In-frame	ENST00000587544	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+
intron-3CDS	ENST00000587118	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336861	KRT13	chr17	39658938	-	ENST00000327158	TIMM22	chr17	902751	+	3803	1070	47	1219	390
ENST00000246635	KRT13	chr17	39658938	-	ENST00000327158	TIMM22	chr17	902751	+	3803	1070	47	1219	390
ENST00000587544	KRT13	chr17	39658938	-	ENST00000327158	TIMM22	chr17	902751	+	3819	1086	63	1235	390

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336861	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+	0.003908809	0.9960912
ENST00000246635	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+	0.003908809	0.9960912
ENST00000587544	ENST00000327158	KRT13	chr17	39658938	-	TIMM22	chr17	902751	+	0.003853831	0.9961462

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Fusion Genomic Features for KRT13-TIMM22

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KRT13	chr17	39658938	-	TIMM22	chr17	902751	+	0.7760522	0.22394784
KRT13	chr17	39658938	-	TIMM22	chr17	902751	+	0.7760522	0.22394784

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KRT13-TIMM22

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:39658938/chr17:902751)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

13_102

341

459.0

Compositional bias

Note=Gly-rich

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

13_102

341

421.0

Compositional bias

Note=Gly-rich

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

104_139

341

459.0

Region

Note=Coil 1A

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

140_158

341

459.0

Region

Note=Linker 1

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

159_250

341

459.0

Region

Note=Coil 1B

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

1_103

341

459.0

Region

Note=Head

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

251_273

341

459.0

Region

Note=Linker 12

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

104_139

341

421.0

Region

Note=Coil 1A

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

140_158

341

421.0

Region

Note=Linker 1

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

159_250

341

421.0

Region

Note=Coil 1B

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

1_103

341

421.0

Region

Note=Head

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

251_273

341

421.0

Region

Note=Linker 12

Tgene

TIMM22

chr17:39658938

chr17:902751

ENST00000327158

170_190

145

195.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

104_416

341

459.0

Domain

IF rod

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

104_416

341

421.0

Domain

IF rod

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

274_412

341

459.0

Region

Note=Coil 2

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000246635

413_458

341

459.0

Region

Note=Tail

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

274_412

341

421.0

Region

Note=Coil 2

Hgene

KRT13

chr17:39658938

chr17:902751

ENST00000336861

413_458

341

421.0

Region

Note=Tail

Tgene

TIMM22

chr17:39658938

chr17:902751

ENST00000327158

123_143

145

195.0

Transmembrane

Helical

Tgene

TIMM22

chr17:39658938

chr17:902751

ENST00000327158

74_94

145

195.0

Transmembrane

Helical

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Fusion Gene Sequence for KRT13-TIMM22

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43493_43493_1_KRT13-TIMM22_KRT13_chr17_39658938_ENST00000246635_TIMM22_chr17_902751_ENST00000327158_length(transcript)=3803nt_BP=1070nt
GGCCAAGCAAGCTTCTATCTGCACCTGCTCTCAATCCTGCTCTCACCATGAGCCTCCGCCTGCAGAGCTCCTCTGCCAGCTATGGAGGTG
GTTTCGGGGGTGGCTCTTGCCAGCTGGGAGGAGGCCGTGGTGTCTCTACCTGTTCAACTCGGTTTGTGTCCGGGGGATCAGCTGGGGGCT
ATGGAGGCGGCGTGAGCTGTGGTTTTGGTGGAGGGGCTGGTAGTGGCTTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTATGGAG
GTGGCCTTGGAGGTGGCTTTGGTGGGGGTTTTGCTGGTGGCTTTGTTGACTTTGGTGCTTGTGATGGCGGCCTCCTCACTGGCAATGAGA
AGATCACCATGCAGAACCTCAACGACCGCCTGGCTTCCTACCTGGAGAAGGTGCGCGCCCTGGAGGAGGCCAACGCTGACCTGGAGGTGA
AGATCCGTGACTGGCACCTGAAGCAGAGCCCAGCTAGCCCTGAGCGGGACTACAGCCCCTACTACAAGACCATTGAAGAGCTCCGGGACA
AGATCCTGACCGCCACCATTGAAAACAACCGGGTCATCCTGGAGATTGACAATGCCAGGCTGGCTGCGGACGACTTCAGGCTCAAGTATG
AGAATGAGCTGGCCCTGCGCCAGAGCGTGGAGGCCGACATCAACGGCCTGCGCCGGGTGCTGGATGAGCTCACTCTGTCTAAGACTGACC
TGGAGATGCAGATCGAGAGCCTGAATGAAGAGCTAGCCTACATGAAGAAGAACCATGAAGAGGAGATGAAGGAATTTAGCAACCAGGTGG
TCGGCCAGGTCAACGTGGAGATGGATGCCACCCCAGGCATTGACCTGACCCGCGTGCTGGCAGAGATGAGGGAGCAGTACGAGGCCATGG
CAGAGAGGAACCGCCGGGATGCTGAGGAATGGTTCCACACCAAGAGTGCAGAGCTGAACAAGGAGGTGTCTACCAACACTGCCATGATTC
AGACCAGCAAGACAGAGATCACGGAGCTCAGGCGCACGCTCCAAGGCCTGGAGATTGAGCTGCAGTCCCAGCTGAGCATGTACCGGGGAA
CATCAGACTGGAAGAACAGTGTCATCAGTGGCTGCATCACGGGAGGAGCTATTGGTTTCAGAGCTGGCTTAAAGGCTGGGGCCATTGGTT
GTGGAGGTTTTGCTGCTTTCTCTGCTGCGATTGATTATTACCTCCGGTGAGAGTAATTGCCTGCAGGGAAGGATGATGCCAGCCCCGGAT
CCGGGCTGCTCTCTGGAGGACAGTTTCTGTACCACACCAGGGCCTTGCTTCAGGGCCTGAAGACATTCATTTTCCCTCATGTCGTTGGTA
TTCTGAGGGAGCTGCCTGGCTTCTCTGCCTCCAGCCTTTGGGGTAGCCACACTTTGCTGCTCCTGGACTCCAGCCAGCCTTCACAGAGGA
CGTCCCGTGCCAGATTCTCTCACAGCAGATCGGGAGACAGGATGTTGACATATAGGAATTCAGCTCCACAAAGCTTCAGGCCTGACCACA
GCTGGCCCTCTAGGTTGTTTGGTGTTGTGGGCACAGAGGTGACAGTGTCTCTGCAGGCACTCAGGAAGCTGTTCTACCTTGGAACTCCAT
GCAACTATCCGTCTCGAATACCAGGGCAGGGCAAGGCGGACTGATGCCGTCCAACCAATTATCTCACTTGTTTTGTGTTCTGTCATCCTT
GTTTTTTTTTTAAAAATACACTCCCCTCCCCCACCGCCACACACCTTACAGTTCAAAAGGTTGGTTTATTTGTATTTTATTTTCAAATTC
CCTATTCCAAAAATAGTGCCGGGTGGCCCAAAGATAACATCTGAAGGGAAAGAATGAGAAAGCTCCCAGGGAAGCGGGGGATGGGGCGCT
GAGGCAGGGTTGTTAGAGGACTGTGTCATCCTCACCAAGCTCATTACATCTGCCAGGGCCTGCCTCAAGAAGCCCAGCCCAGCCTTTTCC
TGGGATGCAGTGAAATCCCATCCATGAACTCGATGGGCCCCTCCTGTGCCGGCCGAGAGGCACACACTGCCTTCACGACGTGACTGCTGG
ACCTGGCCGAGCTTGAGGCCACATGTGAAGGGTCCTGCTGTGGTCATCTTGGTGACTCGGTCACAGCAGCTACTGGCCAAGATCAGACGT
CGCTGAGGGGCTGTTCACCACCATCCTCGTTCTCCAGGGTCAAGGAAGTGTTTTAACATGTCGTGTTTTCGACTTGACCTTGTGGTATTT
TTCTTGGCCTAGTTGTGTGCCATGGATATTAAAAAAAAAAAAAAAAAAATCCGTCTACAGTTGGGCTTCAGCACTGGTGCTGCTTTACCC
TGGTGCTCTGTGGGGGGATGACACTGCTGGAGTCAGGCCTTTGCTCTTGGGTGGGGCACAGGCAGGTCGCTTGGTGGGGGCCACACAGTG
CTGGGCACCTTCAGCCAGTGGTGATGAGTCTCCTTTTTCCTATAATACGGTAATTCCTCTATCCTTTCCTTTTTTGCCTTCTTCCTCATC
TGCCCTGTCTTCTGGCCCACACACTCTTAACCAGCGTTCACACTCAGTGTACATGGCCTGGAGGCCCGAGTGTTTGTACATGAGTGATGA
TGTCAAACCCAGCTGGTAACACCTTCCTTGGGTCATGTTTGCCATTTTCTTGGAATGAATGTGAGTTCCTGCTCAGGGCTCATGTCCTTT
TACAGTGAATTCTATATAACGCCCCTCCCAGTCTCACAGCTAGGAGGCTTCATCACTGCTAGGCCAGTTGGAGCGTTCCCTAGAGCTCAG
AACAAATTGTTTCCTCTGCTGTCCCTAAATATAGGACACCTACAAGCACTCTGAAGCAAGGGCAGACATTCCCACCTGGTACCTGTCAAA
GTCCTAGGATGCCTGGGATCTTCCATCTTTCAGTCTAGCACGTGGGACCAAATACAAGAGATGCTGCCCTCACAACAGCCTTGGAAAAGA
TGAGCGCCAGGGCTGTCAGTACCCATCGGTTCAGTAAGCGAGGCATTGTCCACGCTGCCTATTCACTCGAGAGATGAATAGTTTCCTGTT
TTCGATGGCTGGGGAGCCAGTATGAGCTCATAAACCAAACAGCAATTTTCAGAGACATCTGTTCCTGATCTTCAGAATAAACTCAGTGTC
CAGTTGCTTCGGCTGGTGGGAGCCAATATTCACGCCACTGACTCTCTCAAAGGGAGGGTGGGCCCTCGGAGACCCAGCTTCTCTGACAAG
CAGATTAGACCAAAAGGCTGCCTCAAAGATATGCCACTTTGAAGGAAAGCGTAGAGAAGCGTTTACATAAAAGAAGACGCTTCCTGTTCA
GTGGACAACTTCATGCCACTTTCAAGGCACACCGATGGCCAGGTGGGACATTTGTACTGTAGCAGCACATGGCAAAGGTGAGCCAGAAGC
AGCCTGGATGCTGGCTGATCCGGAGGCCTTTGTGAAGAGCAAGGAGAGGGCTCCAGCCCACCTCCCCGCAGCTCTGCCCCAGCCCCCGTG
GGCCACAGGGAGGCTCAAGGGGAGTGAACTAGGTAAACAGATTCCTGGAAACTCACATCTGGATGCAGCTGGAAGAGTTAAATATTTACA
TTGGTGGCTTCCCTGGACCACCGCGAACACAAACATCCACACCACAGGGCTGAGTTTTGTGCAAATGATGGGGCTTTGCATTTTTTATTA
ACATTTTCCTCTCACGTGGTTTACATCAATTTATAATAATCTACATAAGTTGAAACAGAACATAGACAAAAAAATATATCCTTACCAACT

>43493_43493_1_KRT13-TIMM22_KRT13_chr17_39658938_ENST00000246635_TIMM22_chr17_902751_ENST00000327158_length(amino acids)=390AA_BP=341
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFV
DFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEI
DNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL
TRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMYRGTSDWKNSVISGCITGG

--------------------------------------------------------------
>43493_43493_2_KRT13-TIMM22_KRT13_chr17_39658938_ENST00000336861_TIMM22_chr17_902751_ENST00000327158_length(transcript)=3803nt_BP=1070nt
GGCCAAGCAAGCTTCTATCTGCACCTGCTCTCAATCCTGCTCTCACCATGAGCCTCCGCCTGCAGAGCTCCTCTGCCAGCTATGGAGGTG
GTTTCGGGGGTGGCTCTTGCCAGCTGGGAGGAGGCCGTGGTGTCTCTACCTGTTCAACTCGGTTTGTGTCCGGGGGATCAGCTGGGGGCT
ATGGAGGCGGCGTGAGCTGTGGTTTTGGTGGAGGGGCTGGTAGTGGCTTTGGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTATGGAG
GTGGCCTTGGAGGTGGCTTTGGTGGGGGTTTTGCTGGTGGCTTTGTTGACTTTGGTGCTTGTGATGGCGGCCTCCTCACTGGCAATGAGA
AGATCACCATGCAGAACCTCAACGACCGCCTGGCTTCCTACCTGGAGAAGGTGCGCGCCCTGGAGGAGGCCAACGCTGACCTGGAGGTGA
AGATCCGTGACTGGCACCTGAAGCAGAGCCCAGCTAGCCCTGAGCGGGACTACAGCCCCTACTACAAGACCATTGAAGAGCTCCGGGACA
AGATCCTGACCGCCACCATTGAAAACAACCGGGTCATCCTGGAGATTGACAATGCCAGGCTGGCTGCGGACGACTTCAGGCTCAAGTATG
AGAATGAGCTGGCCCTGCGCCAGAGCGTGGAGGCCGACATCAACGGCCTGCGCCGGGTGCTGGATGAGCTCACTCTGTCTAAGACTGACC
TGGAGATGCAGATCGAGAGCCTGAATGAAGAGCTAGCCTACATGAAGAAGAACCATGAAGAGGAGATGAAGGAATTTAGCAACCAGGTGG
TCGGCCAGGTCAACGTGGAGATGGATGCCACCCCAGGCATTGACCTGACCCGCGTGCTGGCAGAGATGAGGGAGCAGTACGAGGCCATGG
CAGAGAGGAACCGCCGGGATGCTGAGGAATGGTTCCACACCAAGAGTGCAGAGCTGAACAAGGAGGTGTCTACCAACACTGCCATGATTC
AGACCAGCAAGACAGAGATCACGGAGCTCAGGCGCACGCTCCAAGGCCTGGAGATTGAGCTGCAGTCCCAGCTGAGCATGTACCGGGGAA
CATCAGACTGGAAGAACAGTGTCATCAGTGGCTGCATCACGGGAGGAGCTATTGGTTTCAGAGCTGGCTTAAAGGCTGGGGCCATTGGTT
GTGGAGGTTTTGCTGCTTTCTCTGCTGCGATTGATTATTACCTCCGGTGAGAGTAATTGCCTGCAGGGAAGGATGATGCCAGCCCCGGAT
CCGGGCTGCTCTCTGGAGGACAGTTTCTGTACCACACCAGGGCCTTGCTTCAGGGCCTGAAGACATTCATTTTCCCTCATGTCGTTGGTA
TTCTGAGGGAGCTGCCTGGCTTCTCTGCCTCCAGCCTTTGGGGTAGCCACACTTTGCTGCTCCTGGACTCCAGCCAGCCTTCACAGAGGA
CGTCCCGTGCCAGATTCTCTCACAGCAGATCGGGAGACAGGATGTTGACATATAGGAATTCAGCTCCACAAAGCTTCAGGCCTGACCACA
GCTGGCCCTCTAGGTTGTTTGGTGTTGTGGGCACAGAGGTGACAGTGTCTCTGCAGGCACTCAGGAAGCTGTTCTACCTTGGAACTCCAT
GCAACTATCCGTCTCGAATACCAGGGCAGGGCAAGGCGGACTGATGCCGTCCAACCAATTATCTCACTTGTTTTGTGTTCTGTCATCCTT
GTTTTTTTTTTAAAAATACACTCCCCTCCCCCACCGCCACACACCTTACAGTTCAAAAGGTTGGTTTATTTGTATTTTATTTTCAAATTC
CCTATTCCAAAAATAGTGCCGGGTGGCCCAAAGATAACATCTGAAGGGAAAGAATGAGAAAGCTCCCAGGGAAGCGGGGGATGGGGCGCT
GAGGCAGGGTTGTTAGAGGACTGTGTCATCCTCACCAAGCTCATTACATCTGCCAGGGCCTGCCTCAAGAAGCCCAGCCCAGCCTTTTCC
TGGGATGCAGTGAAATCCCATCCATGAACTCGATGGGCCCCTCCTGTGCCGGCCGAGAGGCACACACTGCCTTCACGACGTGACTGCTGG
ACCTGGCCGAGCTTGAGGCCACATGTGAAGGGTCCTGCTGTGGTCATCTTGGTGACTCGGTCACAGCAGCTACTGGCCAAGATCAGACGT
CGCTGAGGGGCTGTTCACCACCATCCTCGTTCTCCAGGGTCAAGGAAGTGTTTTAACATGTCGTGTTTTCGACTTGACCTTGTGGTATTT
TTCTTGGCCTAGTTGTGTGCCATGGATATTAAAAAAAAAAAAAAAAAAATCCGTCTACAGTTGGGCTTCAGCACTGGTGCTGCTTTACCC
TGGTGCTCTGTGGGGGGATGACACTGCTGGAGTCAGGCCTTTGCTCTTGGGTGGGGCACAGGCAGGTCGCTTGGTGGGGGCCACACAGTG
CTGGGCACCTTCAGCCAGTGGTGATGAGTCTCCTTTTTCCTATAATACGGTAATTCCTCTATCCTTTCCTTTTTTGCCTTCTTCCTCATC
TGCCCTGTCTTCTGGCCCACACACTCTTAACCAGCGTTCACACTCAGTGTACATGGCCTGGAGGCCCGAGTGTTTGTACATGAGTGATGA
TGTCAAACCCAGCTGGTAACACCTTCCTTGGGTCATGTTTGCCATTTTCTTGGAATGAATGTGAGTTCCTGCTCAGGGCTCATGTCCTTT
TACAGTGAATTCTATATAACGCCCCTCCCAGTCTCACAGCTAGGAGGCTTCATCACTGCTAGGCCAGTTGGAGCGTTCCCTAGAGCTCAG
AACAAATTGTTTCCTCTGCTGTCCCTAAATATAGGACACCTACAAGCACTCTGAAGCAAGGGCAGACATTCCCACCTGGTACCTGTCAAA
GTCCTAGGATGCCTGGGATCTTCCATCTTTCAGTCTAGCACGTGGGACCAAATACAAGAGATGCTGCCCTCACAACAGCCTTGGAAAAGA
TGAGCGCCAGGGCTGTCAGTACCCATCGGTTCAGTAAGCGAGGCATTGTCCACGCTGCCTATTCACTCGAGAGATGAATAGTTTCCTGTT
TTCGATGGCTGGGGAGCCAGTATGAGCTCATAAACCAAACAGCAATTTTCAGAGACATCTGTTCCTGATCTTCAGAATAAACTCAGTGTC
CAGTTGCTTCGGCTGGTGGGAGCCAATATTCACGCCACTGACTCTCTCAAAGGGAGGGTGGGCCCTCGGAGACCCAGCTTCTCTGACAAG
CAGATTAGACCAAAAGGCTGCCTCAAAGATATGCCACTTTGAAGGAAAGCGTAGAGAAGCGTTTACATAAAAGAAGACGCTTCCTGTTCA
GTGGACAACTTCATGCCACTTTCAAGGCACACCGATGGCCAGGTGGGACATTTGTACTGTAGCAGCACATGGCAAAGGTGAGCCAGAAGC
AGCCTGGATGCTGGCTGATCCGGAGGCCTTTGTGAAGAGCAAGGAGAGGGCTCCAGCCCACCTCCCCGCAGCTCTGCCCCAGCCCCCGTG
GGCCACAGGGAGGCTCAAGGGGAGTGAACTAGGTAAACAGATTCCTGGAAACTCACATCTGGATGCAGCTGGAAGAGTTAAATATTTACA
TTGGTGGCTTCCCTGGACCACCGCGAACACAAACATCCACACCACAGGGCTGAGTTTTGTGCAAATGATGGGGCTTTGCATTTTTTATTA
ACATTTTCCTCTCACGTGGTTTACATCAATTTATAATAATCTACATAAGTTGAAACAGAACATAGACAAAAAAATATATCCTTACCAACT

>43493_43493_2_KRT13-TIMM22_KRT13_chr17_39658938_ENST00000336861_TIMM22_chr17_902751_ENST00000327158_length(amino acids)=390AA_BP=341
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFV
DFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEI
DNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL
TRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMYRGTSDWKNSVISGCITGG

--------------------------------------------------------------
>43493_43493_3_KRT13-TIMM22_KRT13_chr17_39658938_ENST00000587544_TIMM22_chr17_902751_ENST00000327158_length(transcript)=3819nt_BP=1086nt
CACAGTCCTCGGCCCAGGCCAAGCAAGCTTCTATCTGCACCTGCTCTCAATCCTGCTCTCACCATGAGCCTCCGCCTGCAGAGCTCCTCT
GCCAGCTATGGAGGTGGTTTCGGGGGTGGCTCTTGCCAGCTGGGAGGAGGCCGTGGTGTCTCTACCTGTTCAACTCGGTTTGTGTCCGGG
GGATCAGCTGGGGGCTATGGAGGCGGCGTGAGCTGTGGTTTTGGTGGAGGGGCTGGTAGTGGCTTTGGAGGTGGCTATGGAGGTGGCCTT
GGAGGTGGCTATGGAGGTGGCCTTGGAGGTGGCTTTGGTGGGGGTTTTGCTGGTGGCTTTGTTGACTTTGGTGCTTGTGATGGCGGCCTC
CTCACTGGCAATGAGAAGATCACCATGCAGAACCTCAACGACCGCCTGGCTTCCTACCTGGAGAAGGTGCGCGCCCTGGAGGAGGCCAAC
GCTGACCTGGAGGTGAAGATCCGTGACTGGCACCTGAAGCAGAGCCCAGCTAGCCCTGAGCGGGACTACAGCCCCTACTACAAGACCATT
GAAGAGCTCCGGGACAAGATCCTGACCGCCACCATTGAAAACAACCGGGTCATCCTGGAGATTGACAATGCCAGGCTGGCTGCGGACGAC
TTCAGGCTCAAGTATGAGAATGAGCTGGCCCTGCGCCAGAGCGTGGAGGCCGACATCAACGGCCTGCGCCGGGTGCTGGATGAGCTCACT
CTGTCTAAGACTGACCTGGAGATGCAGATCGAGAGCCTGAATGAAGAGCTAGCCTACATGAAGAAGAACCATGAAGAGGAGATGAAGGAA
TTTAGCAACCAGGTGGTCGGCCAGGTCAACGTGGAGATGGATGCCACCCCAGGCATTGACCTGACCCGCGTGCTGGCAGAGATGAGGGAG
CAGTACGAGGCCATGGCAGAGAGGAACCGCCGGGATGCTGAGGAATGGTTCCACACCAAGAGTGCAGAGCTGAACAAGGAGGTGTCTACC
AACACTGCCATGATTCAGACCAGCAAGACAGAGATCACGGAGCTCAGGCGCACGCTCCAAGGCCTGGAGATTGAGCTGCAGTCCCAGCTG
AGCATGTACCGGGGAACATCAGACTGGAAGAACAGTGTCATCAGTGGCTGCATCACGGGAGGAGCTATTGGTTTCAGAGCTGGCTTAAAG
GCTGGGGCCATTGGTTGTGGAGGTTTTGCTGCTTTCTCTGCTGCGATTGATTATTACCTCCGGTGAGAGTAATTGCCTGCAGGGAAGGAT
GATGCCAGCCCCGGATCCGGGCTGCTCTCTGGAGGACAGTTTCTGTACCACACCAGGGCCTTGCTTCAGGGCCTGAAGACATTCATTTTC
CCTCATGTCGTTGGTATTCTGAGGGAGCTGCCTGGCTTCTCTGCCTCCAGCCTTTGGGGTAGCCACACTTTGCTGCTCCTGGACTCCAGC
CAGCCTTCACAGAGGACGTCCCGTGCCAGATTCTCTCACAGCAGATCGGGAGACAGGATGTTGACATATAGGAATTCAGCTCCACAAAGC
TTCAGGCCTGACCACAGCTGGCCCTCTAGGTTGTTTGGTGTTGTGGGCACAGAGGTGACAGTGTCTCTGCAGGCACTCAGGAAGCTGTTC
TACCTTGGAACTCCATGCAACTATCCGTCTCGAATACCAGGGCAGGGCAAGGCGGACTGATGCCGTCCAACCAATTATCTCACTTGTTTT
GTGTTCTGTCATCCTTGTTTTTTTTTTAAAAATACACTCCCCTCCCCCACCGCCACACACCTTACAGTTCAAAAGGTTGGTTTATTTGTA
TTTTATTTTCAAATTCCCTATTCCAAAAATAGTGCCGGGTGGCCCAAAGATAACATCTGAAGGGAAAGAATGAGAAAGCTCCCAGGGAAG
CGGGGGATGGGGCGCTGAGGCAGGGTTGTTAGAGGACTGTGTCATCCTCACCAAGCTCATTACATCTGCCAGGGCCTGCCTCAAGAAGCC
CAGCCCAGCCTTTTCCTGGGATGCAGTGAAATCCCATCCATGAACTCGATGGGCCCCTCCTGTGCCGGCCGAGAGGCACACACTGCCTTC
ACGACGTGACTGCTGGACCTGGCCGAGCTTGAGGCCACATGTGAAGGGTCCTGCTGTGGTCATCTTGGTGACTCGGTCACAGCAGCTACT
GGCCAAGATCAGACGTCGCTGAGGGGCTGTTCACCACCATCCTCGTTCTCCAGGGTCAAGGAAGTGTTTTAACATGTCGTGTTTTCGACT
TGACCTTGTGGTATTTTTCTTGGCCTAGTTGTGTGCCATGGATATTAAAAAAAAAAAAAAAAAAATCCGTCTACAGTTGGGCTTCAGCAC
TGGTGCTGCTTTACCCTGGTGCTCTGTGGGGGGATGACACTGCTGGAGTCAGGCCTTTGCTCTTGGGTGGGGCACAGGCAGGTCGCTTGG
TGGGGGCCACACAGTGCTGGGCACCTTCAGCCAGTGGTGATGAGTCTCCTTTTTCCTATAATACGGTAATTCCTCTATCCTTTCCTTTTT
TGCCTTCTTCCTCATCTGCCCTGTCTTCTGGCCCACACACTCTTAACCAGCGTTCACACTCAGTGTACATGGCCTGGAGGCCCGAGTGTT
TGTACATGAGTGATGATGTCAAACCCAGCTGGTAACACCTTCCTTGGGTCATGTTTGCCATTTTCTTGGAATGAATGTGAGTTCCTGCTC
AGGGCTCATGTCCTTTTACAGTGAATTCTATATAACGCCCCTCCCAGTCTCACAGCTAGGAGGCTTCATCACTGCTAGGCCAGTTGGAGC
GTTCCCTAGAGCTCAGAACAAATTGTTTCCTCTGCTGTCCCTAAATATAGGACACCTACAAGCACTCTGAAGCAAGGGCAGACATTCCCA
CCTGGTACCTGTCAAAGTCCTAGGATGCCTGGGATCTTCCATCTTTCAGTCTAGCACGTGGGACCAAATACAAGAGATGCTGCCCTCACA
ACAGCCTTGGAAAAGATGAGCGCCAGGGCTGTCAGTACCCATCGGTTCAGTAAGCGAGGCATTGTCCACGCTGCCTATTCACTCGAGAGA
TGAATAGTTTCCTGTTTTCGATGGCTGGGGAGCCAGTATGAGCTCATAAACCAAACAGCAATTTTCAGAGACATCTGTTCCTGATCTTCA
GAATAAACTCAGTGTCCAGTTGCTTCGGCTGGTGGGAGCCAATATTCACGCCACTGACTCTCTCAAAGGGAGGGTGGGCCCTCGGAGACC
CAGCTTCTCTGACAAGCAGATTAGACCAAAAGGCTGCCTCAAAGATATGCCACTTTGAAGGAAAGCGTAGAGAAGCGTTTACATAAAAGA
AGACGCTTCCTGTTCAGTGGACAACTTCATGCCACTTTCAAGGCACACCGATGGCCAGGTGGGACATTTGTACTGTAGCAGCACATGGCA
AAGGTGAGCCAGAAGCAGCCTGGATGCTGGCTGATCCGGAGGCCTTTGTGAAGAGCAAGGAGAGGGCTCCAGCCCACCTCCCCGCAGCTC
TGCCCCAGCCCCCGTGGGCCACAGGGAGGCTCAAGGGGAGTGAACTAGGTAAACAGATTCCTGGAAACTCACATCTGGATGCAGCTGGAA
GAGTTAAATATTTACATTGGTGGCTTCCCTGGACCACCGCGAACACAAACATCCACACCACAGGGCTGAGTTTTGTGCAAATGATGGGGC
TTTGCATTTTTTATTAACATTTTCCTCTCACGTGGTTTACATCAATTTATAATAATCTACATAAGTTGAAACAGAACATAGACAAAAAAA

>43493_43493_3_KRT13-TIMM22_KRT13_chr17_39658938_ENST00000587544_TIMM22_chr17_902751_ENST00000327158_length(amino acids)=390AA_BP=341
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSGFGGGYGGGLGGGYGGGLGGGFGGGFAGGFV
DFGACDGGLLTGNEKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEI
DNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMKKNHEEEMKEFSNQVVGQVNVEMDATPGIDL
TRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMYRGTSDWKNSVISGCITGG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KRT13-TIMM22

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KRT13-TIMM22

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KRT13-TIMM22

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source