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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:KRT14-CYP2C18 (FusionGDB2 ID:43497) |
Fusion Gene Summary for KRT14-CYP2C18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KRT14-CYP2C18 | Fusion gene ID: 43497 | Hgene | Tgene | Gene symbol | KRT14 | CYP2C18 | Gene ID | 3861 | 1562 |
| Gene name | keratin 14 | cytochrome P450 family 2 subfamily C member 18 | |
| Synonyms | CK14|EBS3|EBS4|K14|NFJ | CPCI|CYP2C|CYP2C17|P450-6B/29C|P450IIC17 | |
| Cytomap | 17q21.2 | 10q23.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | keratin, type I cytoskeletal 14cytokeratin 14keratin 14, type I | cytochrome P450 2C18(S)-mephenytoin hydroxylase associated cytochrome P450CYPIIC18cytochrome P450, family 2, subfamily C, polypeptide 18cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17cytochrome P450, subfamily IIC (mephenyt | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | P33260 | |
| Ensembl transtripts involved in fusion gene | ENST00000167586, | ENST00000285979, ENST00000339022, | |
| Fusion gene scores | * DoF score | 20 X 16 X 4=1280 | 4 X 3 X 3=36 |
| # samples | 21 | 6 | |
| ** MAII score | log2(21/1280*10)=-2.60768257722124 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: KRT14 [Title/Abstract] AND CYP2C18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | KRT14(39738531)-CYP2C18(96447527), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KRT14 | GO:0007568 | aging | 21916889 |
| Hgene | KRT14 | GO:0042633 | hair cycle | 21916889 |
| Tgene | CYP2C18 | GO:0042573 | retinoic acid metabolic process | 11093772 |
| Fusion gene breakpoints across KRT14 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CYP2C18 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CQ-6229-01A | KRT14 | chr17 | 39738531 | - | CYP2C18 | chr10 | 96447527 | + |
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Fusion Gene ORF analysis for KRT14-CYP2C18 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000167586 | ENST00000285979 | KRT14 | chr17 | 39738531 | - | CYP2C18 | chr10 | 96447527 | + |
| In-frame | ENST00000167586 | ENST00000339022 | KRT14 | chr17 | 39738531 | - | CYP2C18 | chr10 | 96447527 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000167586 | KRT14 | chr17 | 39738531 | - | ENST00000339022 | CYP2C18 | chr10 | 96447527 | + | 3534 | 1662 | 87 | 1505 | 472 |
| ENST00000167586 | KRT14 | chr17 | 39738531 | - | ENST00000285979 | CYP2C18 | chr10 | 96447527 | + | 3713 | 1662 | 87 | 1505 | 472 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000167586 | ENST00000339022 | KRT14 | chr17 | 39738531 | - | CYP2C18 | chr10 | 96447527 | + | 0.005156142 | 0.99484384 |
| ENST00000167586 | ENST00000285979 | KRT14 | chr17 | 39738531 | - | CYP2C18 | chr10 | 96447527 | + | 0.004363868 | 0.99563617 |
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Fusion Genomic Features for KRT14-CYP2C18 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| KRT14 | chr17 | 39738530 | - | CYP2C18 | chr10 | 96447526 | + | 0.001456374 | 0.9985436 |
| KRT14 | chr17 | 39738530 | - | CYP2C18 | chr10 | 96447526 | + | 0.001456374 | 0.9985436 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for KRT14-CYP2C18 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:39738531/chr10:96447527) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CYP2C18 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000269|PubMed:11093772}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 115_426 | 525 | 473.0 | Domain | IF rod |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 115_150 | 525 | 473.0 | Region | Note=Coil 1A |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 151_168 | 525 | 473.0 | Region | Note=Linker 1 |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 169_260 | 525 | 473.0 | Region | Note=Coil 1B |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 1_114 | 525 | 473.0 | Region | Note=Head |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 261_283 | 525 | 473.0 | Region | Note=Linker 12 |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 284_422 | 525 | 473.0 | Region | Note=Coil 2 |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 423_472 | 525 | 473.0 | Region | Note=Tail |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for KRT14-CYP2C18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >43497_43497_1_KRT14-CYP2C18_KRT14_chr17_39738531_ENST00000167586_CYP2C18_chr10_96447527_ENST00000285979_length(transcript)=3713nt_BP=1662nt AAAGCACTCGCATCCCTTTCCAATTTACCCGAGCACCTTCTCTTCACTCAGCCAACTGCTCGCTCGCTCACCTCCCTCCTCTGCACCATG ACCACCTGCAGCCGCCAGTTCACCTCCTCCAGCTCCATGAAGGGCTCCTGCGGCATCGGGGGCGGCATCGGGGGCGGCTCCAGCCGCATC TCCTCCGTCCTGGCCGGAGGGTCCTGCCGCGCCCCCAGCACCTACGGGGGCGGCCTGTCTGTCTCATCCTCCCGCTTCTCCTCTGGGGGA GCCTGCGGGCTGGGGGGCGGCTATGGCGGTGGCTTCAGCAGCAGCAGCAGCAGCTTTGGTAGTGGCTTTGGGGGAGGATATGGTGGTGGC CTTGGTGCTGGCTTGGGTGGTGGCTTTGGTGGTGGCTTTGCTGGTGGTGATGGGCTTCTGGTGGGCAGTGAGAAGGTGACCATGCAGAAC CTCAATGACCGCCTGGCCTCCTACCTGGACAAGGTGCGTGCTCTGGAGGAGGCCAACGCCGACCTGGAAGTGAAGATCCGTGACTGGTAC CAGAGGCAGCGGCCTGCTGAGATCAAAGACTACAGTCCCTACTTCAAGACCATTGAGGACCTGAGGAACAAGATTCTCACAGCCACAGTG GACAATGCCAATGTCCTTCTGCAGATTGACAATGCCCGTCTGGCCGCGGATGACTTCCGCACCAAGTATGAGACAGAGTTGAACCTGCGC ATGAGTGTGGAAGCCGACATCAATGGCCTGCGCAGGGTGCTGGACGAACTGACCCTGGCCAGAGCTGACCTGGAGATGCAGATTGAGAGC CTGAAGGAGGAGCTGGCCTACCTGAAGAAGAACCACGAGGAGGAGATGAATGCCCTGAGAGGCCAGGTGGGTGGAGATGTCAATGTGGAG ATGGACGCTGCACCTGGCGTGGACCTGAGCCGCATTCTGAACGAGATGCGTGACCAGTATGAGAAGATGGCAGAGAAGAACCGCAAGGAT GCCGAGGAATGGTTCTTCACCAAGACAGAGGAGCTGAACCGCGAGGTGGCCACCAACAGCGAGCTGGTGCAGAGCGGCAAGAGCGAGATC TCGGAGCTCCGGCGCACCATGCAGAACCTGGAGATTGAGCTGCAGTCCCAGCTCAGCATGAAAGCATCCCTGGAGAACAGCCTGGAGGAG ACCAAAGGTCGCTACTGCATGCAGCTGGCCCAGATCCAGGAGATGATTGGCAGCGTGGAGGAGCAGCTGGCCCAGCTCCGCTGCGAGATG GAGCAGCAGAACCAGGAGTACAAGATCCTGCTGGACGTGAAGACGCGGCTGGAGCAGGAGATCGCCACCTACCGCCGCCTGCTGGAGGGC GAGGACGCCCACCTCTCCTCCTCCCAGTTCTCCTCTGGATCGCAGTCATCCAGAGATGTGACCTCCTCCAGCCGCCAAATCCGCACCAAG GTCATGGATGTGCACGATGGCAAGGTGGTGTCCACCCACGAGCAGGTCCTTCGCACCAAGAACTGAGGCTGCCCAGCCCCGCTCAGGCCT AGGAGGCCCCCCGTGTGGACACAGATCCCACTGGAAGATCCCCTCTCCTGCCCAAGCACTTCACAGCTGGACCCTGCTTCACCCTCACCC CCTCCTGGCAATCAATACAGCTTCATTATCTGAGTTGCATAATTCTCAAAAGTCTATGGCCCTGTGTTCACTGTGTATTTTGGCCTGAAG CCCATTGTGGTGTTGCATGGATATGAAGCAGTGAAGGAGGCCCTGATTGATCATGGAGAGGAGTTTTCTGGAAGAGGAAGTTTTCCAGTG GCTGAAAAAGTTAACAAAGGACTTGGAATCCTTTTCAGCAATGGAAAGAGATGGAAGGAGATCCGGCGTTTCTGCCTCATGACTCTGCGG AATTTTGGGATGGGGAAGAGGAGCATCGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAATGCCTCA CCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCTGTTATTTTCCATGATCGATTTGATTATAAAGATCAG AGGTTTCTTAACTTGATGGAAAAATTCAATGAAAACCTCAGGATTCTGAGCTCTCCATGGATCCAGGTCTGCAATAATTTCCCTGCTCTC ATCGATTATCTCCCAGGAAGTCATAATAAAATAGCTGAAAATTTTGCTTACATTAAAAGTTATGTATTGGAGAGAATAAAAGAACATCAA GAATCCCTGGACATGAACAGTGCTCGGGACTTTATTGATTGTTTCCTGATCAAAATGGAACAGGAAAAGCACAATCAACAGTCTGAATTT ACTGTTGAAAGCTTGATAGCCACTGTAACTGATATGTTTGGGGCTGGAACAGAGACAACGAGCACCACTCTGAGATATGGACTCCTGCTC CTGCTGAAGTACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGAATGTGTAGTTGGCAGAAACCGGAGCCCCTGTATGCAGGACAGG AGTCACATGCCCTACACAGATGCTGTGGTGCACGAGATCCAGAGATACATTGACCTCCTCCCCACCAACCTGCCCCATGCAGTGACCTGT GATGTTAAATTCAAAAACTACCTCATCCCCAAGGGCACGACCATAATAACATCCCTGACTTCTGTGCTGCACAATGACAAAGAATTCCCC AACCCAGAGATGTTTGACCCTGGCCACTTTCTGGATAAGAGTGGCAACTTTAAGAAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAA CGGATGTGTATGGGAGAGGGCCTGGCCCGCATGGAGCTGTTTTTATTCCTGACCACCATTTTGCAGAACTTTAACCTGAAATCTCAGGTT GACCCAAAGGATATTGACATCACCCCCATTGCCAATGCATTTGGTCGTGTGCCACCCTTGTACCAGCTCTGCTTCATTCCTGTCTGAAGA AGGGCAGATAGTTTGGCTGCTCCTGTGCTGTCACCTGCAATTCTCCCTTATCAGGGCCATTGGCCTCTCCCTTCTCTCTGTGAGGGATAT TTTCTCTGACTTGTCAATCCACATCTTCCCATTCCCTCAAGATCCAATGAACATCCAACCTCCATTAAAGAGAGTTTCTTGGGTCACTTC CTAAATATATCTGCTATTCTCCATACTCTGTATCACTTGTATTGACCACCACATATGCTAATACCTATCTACTGCTGAGTTGTCAGTATG TTATCACTAGAAAACAAAGAAAAATGATTAATAAATGACAATTCAGAGCCATTTATTCTCTGCATGCTCTAGATAAAAATGATTATTATT TACTGGGTCAGTTCTTAGATTTCTTTCTTTTGAGTAAAATGAAAGTAAGAAATGAAAGAAAATAGAATGTGAAGAGGCTGTGCTGGCCCT CATAGTGTTAAGCACAAAAAGGGAGAAAGGTAAGAGGGTAGGAAAGCTGTTTTAGCTAAATGCCACCTAGAGTTATTGGAGGTCTGAATT TGGAAAAAAAAACTATGTCCAGGAGCAGCTGTAACCTGTAGGGAAATACTGGAACAATCATCCATAAGAGGGATGAACATTAAGTGTTTG AATTCATGCTCTGCTTTTGTGTTACTGTAAACACAAGATCAAGATTTGGATAATCTTTTTCCTTTGTGTTTCCAACTTAGATCATGTCTA >43497_43497_1_KRT14-CYP2C18_KRT14_chr17_39738531_ENST00000167586_CYP2C18_chr10_96447527_ENST00000285979_length(amino acids)=472AA_BP= MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGLGGGYGGGFSSSSSSFGSGFGGGYGG GLGAGLGGGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTAT VDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNV EMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLE ETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRT -------------------------------------------------------------- >43497_43497_2_KRT14-CYP2C18_KRT14_chr17_39738531_ENST00000167586_CYP2C18_chr10_96447527_ENST00000339022_length(transcript)=3534nt_BP=1662nt AAAGCACTCGCATCCCTTTCCAATTTACCCGAGCACCTTCTCTTCACTCAGCCAACTGCTCGCTCGCTCACCTCCCTCCTCTGCACCATG ACCACCTGCAGCCGCCAGTTCACCTCCTCCAGCTCCATGAAGGGCTCCTGCGGCATCGGGGGCGGCATCGGGGGCGGCTCCAGCCGCATC TCCTCCGTCCTGGCCGGAGGGTCCTGCCGCGCCCCCAGCACCTACGGGGGCGGCCTGTCTGTCTCATCCTCCCGCTTCTCCTCTGGGGGA GCCTGCGGGCTGGGGGGCGGCTATGGCGGTGGCTTCAGCAGCAGCAGCAGCAGCTTTGGTAGTGGCTTTGGGGGAGGATATGGTGGTGGC CTTGGTGCTGGCTTGGGTGGTGGCTTTGGTGGTGGCTTTGCTGGTGGTGATGGGCTTCTGGTGGGCAGTGAGAAGGTGACCATGCAGAAC CTCAATGACCGCCTGGCCTCCTACCTGGACAAGGTGCGTGCTCTGGAGGAGGCCAACGCCGACCTGGAAGTGAAGATCCGTGACTGGTAC CAGAGGCAGCGGCCTGCTGAGATCAAAGACTACAGTCCCTACTTCAAGACCATTGAGGACCTGAGGAACAAGATTCTCACAGCCACAGTG GACAATGCCAATGTCCTTCTGCAGATTGACAATGCCCGTCTGGCCGCGGATGACTTCCGCACCAAGTATGAGACAGAGTTGAACCTGCGC ATGAGTGTGGAAGCCGACATCAATGGCCTGCGCAGGGTGCTGGACGAACTGACCCTGGCCAGAGCTGACCTGGAGATGCAGATTGAGAGC CTGAAGGAGGAGCTGGCCTACCTGAAGAAGAACCACGAGGAGGAGATGAATGCCCTGAGAGGCCAGGTGGGTGGAGATGTCAATGTGGAG ATGGACGCTGCACCTGGCGTGGACCTGAGCCGCATTCTGAACGAGATGCGTGACCAGTATGAGAAGATGGCAGAGAAGAACCGCAAGGAT GCCGAGGAATGGTTCTTCACCAAGACAGAGGAGCTGAACCGCGAGGTGGCCACCAACAGCGAGCTGGTGCAGAGCGGCAAGAGCGAGATC TCGGAGCTCCGGCGCACCATGCAGAACCTGGAGATTGAGCTGCAGTCCCAGCTCAGCATGAAAGCATCCCTGGAGAACAGCCTGGAGGAG ACCAAAGGTCGCTACTGCATGCAGCTGGCCCAGATCCAGGAGATGATTGGCAGCGTGGAGGAGCAGCTGGCCCAGCTCCGCTGCGAGATG GAGCAGCAGAACCAGGAGTACAAGATCCTGCTGGACGTGAAGACGCGGCTGGAGCAGGAGATCGCCACCTACCGCCGCCTGCTGGAGGGC GAGGACGCCCACCTCTCCTCCTCCCAGTTCTCCTCTGGATCGCAGTCATCCAGAGATGTGACCTCCTCCAGCCGCCAAATCCGCACCAAG GTCATGGATGTGCACGATGGCAAGGTGGTGTCCACCCACGAGCAGGTCCTTCGCACCAAGAACTGAGGCTGCCCAGCCCCGCTCAGGCCT AGGAGGCCCCCCGTGTGGACACAGATCCCACTGGAAGATCCCCTCTCCTGCCCAAGCACTTCACAGCTGGACCCTGCTTCACCCTCACCC CCTCCTGGCAATCAATACAGCTTCATTATCTGAGTTGCATAATTCTCAAAAGTCTATGGCCCTGTGTTCACTGTGTATTTTGGCCTGAAG CCCATTGTGGTGTTGCATGGATATGAAGCAGTGAAGGAGGCCCTGATTGATCATGGAGAGGAGTTTTCTGGAAGAGGAAGTTTTCCAGTG GCTGAAAAAGTTAACAAAGGACTTGGAATCCTTTTCAGCAATGGAAAGAGATGGAAGGAGATCCGGCGTTTCTGCCTCATGACTCTGCGG AATTTTGGGATGGGGAAGAGGAGCATCGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAATGCCTCA CCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCTGTTATTTTCCATGATCGATTTGATTATAAAGATCAG AGGTTTCTTAACTTGATGGAAAAATTCAATGAAAACCTCAGGATTCTGAGCTCTCCATGGATCCAGGAAAAGCACAATCAACAGTCTGAA TTTACTGTTGAAAGCTTGATAGCCACTGTAACTGATATGTTTGGGGCTGGAACAGAGACAACGAGCACCACTCTGAGATATGGACTCCTG CTCCTGCTGAAGTACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGAATGTGTAGTTGGCAGAAACCGGAGCCCCTGTATGCAGGAC AGGAGTCACATGCCCTACACAGATGCTGTGGTGCACGAGATCCAGAGATACATTGACCTCCTCCCCACCAACCTGCCCCATGCAGTGACC TGTGATGTTAAATTCAAAAACTACCTCATCCCCAAGGGCACGACCATAATAACATCCCTGACTTCTGTGCTGCACAATGACAAAGAATTC CCCAACCCAGAGATGTTTGACCCTGGCCACTTTCTGGATAAGAGTGGCAACTTTAAGAAAAGTGACTACTTCATGCCTTTCTCAGCAGGA AAACGGATGTGTATGGGAGAGGGCCTGGCCCGCATGGAGCTGTTTTTATTCCTGACCACCATTTTGCAGAACTTTAACCTGAAATCTCAG GTTGACCCAAAGGATATTGACATCACCCCCATTGCCAATGCATTTGGTCGTGTGCCACCCTTGTACCAGCTCTGCTTCATTCCTGTCTGA AGAAGGGCAGATAGTTTGGCTGCTCCTGTGCTGTCACCTGCAATTCTCCCTTATCAGGGCCATTGGCCTCTCCCTTCTCTCTGTGAGGGA TATTTTCTCTGACTTGTCAATCCACATCTTCCCATTCCCTCAAGATCCAATGAACATCCAACCTCCATTAAAGAGAGTTTCTTGGGTCAC TTCCTAAATATATCTGCTATTCTCCATACTCTGTATCACTTGTATTGACCACCACATATGCTAATACCTATCTACTGCTGAGTTGTCAGT ATGTTATCACTAGAAAACAAAGAAAAATGATTAATAAATGACAATTCAGAGCCATTTATTCTCTGCATGCTCTAGATAAAAATGATTATT ATTTACTGGGTCAGTTCTTAGATTTCTTTCTTTTGAGTAAAATGAAAGTAAGAAATGAAAGAAAATAGAATGTGAAGAGGCTGTGCTGGC CCTCATAGTGTTAAGCACAAAAAGGGAGAAAGGTAAGAGGGTAGGAAAGCTGTTTTAGCTAAATGCCACCTAGAGTTATTGGAGGTCTGA ATTTGGAAAAAAAAACTATGTCCAGGAGCAGCTGTAACCTGTAGGGAAATACTGGAACAATCATCCATAAGAGGGATGAACATTAAGTGT TTGAATTCATGCTCTGCTTTTGTGTTACTGTAAACACAAGATCAAGATTTGGATAATCTTTTTCCTTTGTGTTTCCAACTTAGATCATGT >43497_43497_2_KRT14-CYP2C18_KRT14_chr17_39738531_ENST00000167586_CYP2C18_chr10_96447527_ENST00000339022_length(amino acids)=472AA_BP= MTTCSRQFTSSSSMKGSCGIGGGIGGGSSRISSVLAGGSCRAPSTYGGGLSVSSSRFSSGGACGLGGGYGGGFSSSSSSFGSGFGGGYGG GLGAGLGGGFGGGFAGGDGLLVGSEKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKTIEDLRNKILTAT VDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQVGGDVNV EMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENSLE ETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQSSRDVTSSSRQIRT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for KRT14-CYP2C18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | KRT14 | chr17:39738531 | chr10:96447527 | ENST00000167586 | - | 8 | 8 | 425_472 | 525.0 | 473.0 | Type I keratins and keratin filaments |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for KRT14-CYP2C18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for KRT14-CYP2C18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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