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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:KRT6A-SPINK5 (FusionGDB2 ID:43640)

Fusion Gene Summary for KRT6A-SPINK5

Fusion gene summary

Fusion gene information	Fusion gene name: KRT6A-SPINK5
	Fusion gene ID: 43640
		Hgene	Tgene
	Gene symbol	KRT6A	SPINK5
	Gene ID	3853	11005
	Gene name	keratin 6A	serine peptidase inhibitor Kazal type 5
	Synonyms	CK-6C\|CK-6E\|CK6A\|CK6C\|CK6D\|K6A\|K6C\|K6D\|KRT6C\|KRT6D\|PC3	LEKTI\|LETKI\|NETS\|NS\|VAKTI
	Cytomap	12q13.13	5q32
	Type of gene	protein-coding	protein-coding
	Description	keratin, type II cytoskeletal 6Acytokeratin 6Acytokeratin 6Ccytokeratin 6Dkeratin 6A, , type IIkeratin 6A, type IIkeratin, epidermal type II, K6Atype-II keratin Kb6	serine protease inhibitor Kazal-type 5lympho-epithelial Kazal-type-related inhibitorlymphoepithelial Kazal-type-related inhibitor
	Modification date	20200327	20200313
	UniProtAcc	P02538	.
	Ensembl transtripts involved in fusion gene	ENST00000330722,	ENST00000476608, ENST00000256084, ENST00000359874, ENST00000398454,
Fusion gene scores	* DoF score	17 X 15 X 4=1020	5 X 5 X 3=75
	# samples	18	5
	** MAII score	log2(18/1020*10)=-2.50250034052918 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KRT6A [Title/Abstract] AND SPINK5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	KRT6A(52884641)-SPINK5(147465967), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KRT6A	GO:0001899	negative regulation of cytolysis by symbiont of host cells	23006328
Hgene	KRT6A	GO:0050830	defense response to Gram-positive bacterium	23006328
Hgene	KRT6A	GO:0051838	cytolysis by host of symbiont cells	23006328
Hgene	KRT6A	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	23006328
Hgene	KRT6A	GO:2000536	negative regulation of entry of bacterium into host cell	23006328
Tgene	SPINK5	GO:0009913	epidermal cell differentiation	12915442

Fusion gene breakpoints across KRT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPINK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-IG-A3YC	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+

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Fusion Gene ORF analysis for KRT6A-SPINK5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000330722	ENST00000476608	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+
In-frame	ENST00000330722	ENST00000256084	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+
In-frame	ENST00000330722	ENST00000359874	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+
In-frame	ENST00000330722	ENST00000398454	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000330722	KRT6A	chr12	52884641	-	ENST00000398454	SPINK5	chr5	147465967	+	3541	981	69	3449	1126
ENST00000330722	KRT6A	chr12	52884641	-	ENST00000359874	SPINK5	chr5	147465967	+	4282	981	69	3983	1304
ENST00000330722	KRT6A	chr12	52884641	-	ENST00000256084	SPINK5	chr5	147465967	+	4192	981	69	3893	1274

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000330722	ENST00000398454	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+	0.001953566	0.9980464
ENST00000330722	ENST00000359874	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+	0.001462551	0.9985374
ENST00000330722	ENST00000256084	KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+	0.002323369	0.9976767

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Fusion Genomic Features for KRT6A-SPINK5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+	0.4232469	0.5767531
KRT6A	chr12	52884641	-	SPINK5	chr5	147465967	+	0.4232469	0.5767531

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KRT6A-SPINK5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:52884641/chr5:147465967)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KRT6A P02538	.
FUNCTION: Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. {ECO:0000250\|UniProtKB:P50446}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

163_198

304

565.0

Region

Note=Coil 1A

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

199_217

304

565.0

Region

Note=Linker 1

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

2_162

304

565.0

Region

Note=Head

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

155_216

1065.0

Domain

Kazal-like 3

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

219_285

1065.0

Domain

Kazal-like 4

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

291_352

1065.0

Domain

Kazal-like 5

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

361_423

1065.0

Domain

Kazal-like 6

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

431_489

1065.0

Domain

Kazal-like 7

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

490_551

1065.0

Domain

Kazal-like 8

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

561_622

1065.0

Domain

Kazal-like 9

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

626_688

1065.0

Domain

Kazal-like 10

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

701_757

1065.0

Domain

Kazal-like 11

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

768_830

1065.0

Domain

Kazal-like 12

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

843_905

1065.0

Domain

Kazal-like 13

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

910_971

1065.0

Domain

Kazal-like 14

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

91_153

1065.0

Domain

Kazal-like 2

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

987_1048

1065.0

Domain

Kazal-like 15

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

155_216

1095.0

Domain

Kazal-like 3

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

219_285

1095.0

Domain

Kazal-like 4

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

291_352

1095.0

Domain

Kazal-like 5

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

361_423

1095.0

Domain

Kazal-like 6

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

431_489

1095.0

Domain

Kazal-like 7

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

490_551

1095.0

Domain

Kazal-like 8

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

561_622

1095.0

Domain

Kazal-like 9

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

626_688

1095.0

Domain

Kazal-like 10

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

701_757

1095.0

Domain

Kazal-like 11

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

768_830

1095.0

Domain

Kazal-like 12

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

843_905

1095.0

Domain

Kazal-like 13

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

910_971

1095.0

Domain

Kazal-like 14

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

91_153

1095.0

Domain

Kazal-like 2

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

987_1048

1095.0

Domain

Kazal-like 15

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

155_216

917.0

Domain

Kazal-like 3

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

219_285

917.0

Domain

Kazal-like 4

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

291_352

917.0

Domain

Kazal-like 5

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

361_423

917.0

Domain

Kazal-like 6

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

431_489

917.0

Domain

Kazal-like 7

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

490_551

917.0

Domain

Kazal-like 8

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

561_622

917.0

Domain

Kazal-like 9

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

626_688

917.0

Domain

Kazal-like 10

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

701_757

917.0

Domain

Kazal-like 11

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

768_830

917.0

Domain

Kazal-like 12

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

843_905

917.0

Domain

Kazal-like 13

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

910_971

917.0

Domain

Kazal-like 14

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

91_153

917.0

Domain

Kazal-like 2

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

987_1048

917.0

Domain

Kazal-like 15

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

163_476

304

565.0

Domain

IF rod

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

218_309

304

565.0

Region

Note=Coil 1B

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

310_333

304

565.0

Region

Note=Linker 12

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

334_472

304

565.0

Region

Note=Coil 2

Hgene

KRT6A

chr12:52884641

chr5:147465967

ENST00000330722

473_564

304

565.0

Region

Note=Tail

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000256084

28_66

1065.0

Domain

Kazal-like 1%3B atypical

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000359874

28_66

1095.0

Domain

Kazal-like 1%3B atypical

Tgene

SPINK5

chr12:52884641

chr5:147465967

ENST00000398454

28_66

917.0

Domain

Kazal-like 1%3B atypical

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Fusion Gene Sequence for KRT6A-SPINK5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43640_43640_1_KRT6A-SPINK5_KRT6A_chr12_52884641_ENST00000330722_SPINK5_chr5_147465967_ENST00000256084_length(transcript)=4192nt_BP=981nt
AGTCCTGCTTCTCTTCCCTCTCTCCTCCAGCCTCTCACACTCTCCTCAGCTCTCTCATCTCCTGGAACCATGGCCAGCACATCCACCACC
ATCAGGAGCCACAGCAGCAGCCGCCGGGGTTTCAGTGCCAACTCAGCCAGGCTCCCTGGGGTCAGCCGCTCTGGCTTCAGCAGCGTCTCC
GTGTCCCGCTCCAGGGGCAGTGGTGGCCTGGGTGGTGCATGTGGAGGAGCTGGCTTTGGCAGCCGCAGTCTGTATGGCCTGGGGGGCTCC
AAGAGGATCTCCATTGGAGGGGGCAGCTGTGCCATCAGTGGCGGCTATGGCAGCAGAGCCGGAGGCAGCTATGGCTTTGGTGGCGCCGGG
AGTGGATTTGGTTTCGGTGGTGGAGCCGGCATTGGCTTTGGTCTGGGTGGTGGAGCCGGCCTTGCTGGTGGCTTTGGGGGCCCTGGCTTC
CCTGTGTGCCCCCCTGGAGGCATCCAAGAGGTCACCGTCAACCAGAGTCTCCTGACTCCCCTCAACCTGCAAATCGATCCCACCATCCAG
CGGGTGCGGGCTGAGGAGCGTGAACAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATCGACAAGGTGCGGTTCCTGGAGCAGCAG
AACAAGGTTCTGGAAACAAAGTGGACCCTGCTGCAGGAGCAGGGCACCAAGACTGTGAGGCAGAACCTGGAGCCGTTGTTCGAGCAGTAC
ATCAACAACCTCAGGAGGCAGCTGGACAGCATTGTCGGGGAACGGGGCCGCCTGGACTCAGAGCTCAGAGGCATGCAGGACCTGGTGGAG
GACTTCAAGAACAAATATGAGGATGAAATCAACAAGCGCACAGCAGCAGAGAATGAATTTGTGACTCTGAAGAAGGATGTGGATGCTGCC
TACATGAACAAGGTTGAACTGCAAGCCAAGGCAGACACTCTCACAGACGAGATCAACTTCCTGAGAGCCTTGTATGATGCACTGAATTGT
GATGATTTTAAAAAAGGAGAAAGAGATGGGGATTTTATCTGTCCTGATTATTATGAAGCTGTTTGTGGCACAGATGGGAAAACATATGAC
AACAGATGTGCACTGTGTGCTGAGAATGCGAAAACCGGGTCCCAAATTGGTGTAAAAAGTGAAGGGGAATGTAAGAGCAGTAATCCAGAG
CAGGATGTATGCAGTGCTTTTCGGCCCTTTGTTAGAGATGGAAGACTTGGATGCACAAGGGAAAATGATCCTGTTCTTGGTCCTGATGGG
AAGACGCATGGCAATAAGTGTGCAATGTGTGCTGAGCTGTTTTTAAAAGAAGCTGAAAATGCCAAGCGAGAGGGTGAAACTAGAATTCGA
CGAAATGCTGAAAAGGATTTTTGCAAGGAATATGAAAAACAAGTGAGAAATGGAAGGCTTTTTTGTACACGGGAGAGTGATCCAGTCCGT
GGCCCTGACGGCAGGATGCATGGCAACAAATGTGCCCTGTGTGCTGAAATTTTCAAGCAGCGTTTTTCAGAGGAAAACAGTAAAACAGAT
CAAAATTTGGGAAAAGCTGAAGAAAAAACTAAAGTTAAAAGAGAAATTGTGAAACTCTGCAGTCAATATCAAAATCAGGCAAAGAATGGA
ATACTTTTCTGTACCAGAGAAAATGACCCTATTCGTGGTCCAGATGGGAAAATGCATGGCAACTTGTGTTCCATGTGTCAAGCCTACTTC
CAAGCAGAAAATGAAGAAAAGAAAAAGGCTGAAGCACGAGCTAGAAACAAAAGAGAATCTGGAAAAGCAACCTCATATGCAGAGCTTTGC
AGTGAATATCGAAAGCTTGTGAGGAACGGAAAACTTGCTTGCACCAGAGAGAACGATCCTATCCAGGGCCCAGATGGGAAAGTGCATGGC
AACACCTGCTCCATGTGTGAGGTCTTCTTCCAAGCAGAAGAAGAAGAAAAGAAAAAGAAGGAAGGTAAATCAAGAAACAAAAGACAATCT
AAGAGTACAGCTTCCTTTGAGGAGTTGTGTAGTGAATACCGCAAATCCAGGAAAAACGGACGGCTTTTTTGCACCAGAGAGAATGACCCC
ATCCAGGGCCCAGATGGAAAAATGCATGGCAACACCTGCTCCATGTGTGAGGCCTTCTTTCAACAAGAAGAAAGAGCAAGAGCAAAGGCT
AAAAGAGAAGCTGCAAAGGAAATCTGCAGTGAATTTCGGGACCAAGTGAGGAATGGAACACTTATATGCACCAGGGAGCATAATCCTGTC
CGTGGCCCAGATGGCAAAATGCATGGAAACAAGTGTGCCATGTGTGCCAGTGTGTTCAAACTTGAAGAAGAAGAGAAGAAAAATGATAAA
GAAGAAAAAGGGAAAGTCGAGGCTGAAAAAGTTAAGAGAGAAGCAGTTCAGGAGCTGTGCAGTGAATATCGTCATTATGTGAGGAATGGA
CGACTCCCCTGTACCAGAGAGAATGATCCTATTGAGGGTCTAGATGGGAAAATCCACGGCAACACCTGCTCCATGTGTGAAGCCTTCTTC
CAGCAAGAAGCAAAAGAAAAAGAAAGAGCTGAACCCAGAGCAAAAGTCAAAAGAGAAGCTGAAAAGGAGACATGCGATGAATTTCGGAGA
CTTTTGCAAAATGGAAAACTTTTCTGCACAAGAGAAAATGATCCTGTGCGTGGCCCAGATGGCAAGACCCATGGCAACAAGTGTGCCATG
TGTAAGGCAGTCTTCCAGAAAGAAAATGAGGAAAGAAAGAGGAAAGAAGAGGAAGATCAGAGAAATGCTGCAGGACATGGTTCCAGTGGT
GGTGGAGGAGGAAACACTCAGGACGAATGTGCTGAGTATCGGGAACAAATGAAAAATGGAAGACTCAGCTGTACTCGGGAGAGTGATCCT
GTACGTGATGCTGATGGCAAATCGTACAACAATCAGTGTACCATGTGTAAAGCAAAATTGGAAAGAGAAGCAGAGAGAAAAAATGAGTAT
TCTCGCTCCAGATCAAATGGGACTGGATCAGAATCAGGGAAGGATACATGTGATGAGTTTAGAAGCCAAATGAAAAATGGAAAACTCATC
TGCACTCGAGAAAGTGACCCTGTCCGGGGTCCAGATGGCAAGACACATGGCAATAAGTGTACTATGTGTAAGGAAAAACTGGAAAGGGAA
GCAGCTGAAAAAAAAAAGAAAGAGGATGAAGACAGGAGCAATACAGGAGAAAGGAGCAATACAGGAGAAAGGAGCAATGACAAAGAGGAT
CTGTGTCGTGAATTTCGAAGCATGCAGAGAAATGGAAAGCTTATCTGCACCAGAGAAAATAACCCTGTTCGAGGCCCATATGGCAAGATG
CACATCAATAAATGTGCTATGTGTCAGAGCATCTTTGATCGAGAAGCTAATGAAAGAAAAAAGAAAGATGAAGAGAAATCAAGTAGCAAG
CCCTCAAATAATGCAAAGGATGAGTGCAGTGAATTTCGAAACTATATAAGGAACAATGAACTCATCTGCCCTAGAGAGAATGACCCAGTG
CACGGTGCTGATGGAAAGTTCTATACAAACAAGTGCTACATGTGCAGAGCTGTCTTTCTAACAGAAGCTTTGGAAAGGGCAAAGCTTCAA
GAAAAGCCATCCCATGTTAGAGCTTCTCAAGAGGAAGACAGCCCAGACTCTTTCAGTTCTCTGGATTCTGAGATGTGCAAAGACTACCGA
GTATTGCCCAGGATAGGTTATCTTTGTCCAAAGGATTTAAAGCCTGTCTGTGGTGACGATGGCCAAACCTACAACAATCCTTGCATGCTC
TGTCATGAAAACCTGATACGCCAAACAAATACACACATCCGCAGTACAGGGAAGTGTGAGGAGAGCAGCACCCCAGGAACCACCGCAGCC
AGCATGCCCCCGTCTGACGAATGACAGGAAGATTGTTGAAAGCCATGAGGGAAAAAATAAACCCCAGTTCTGAATCACCTACCTTCACCA
TCTGTATATACAAAGAATTCTTCGGAGCTTGTCTTATTTGCTATAGAAAACAATACAGAGCTTTTGGGAATGGACTCACTGATTTTCAGT
CTTTTCCATCTCTTTCCTCCTAGACTCTGTGATCTGAGGGTATAAAGACATCTCCACCAAGTCTGAGCCCTCAAAATGTCCTGATTACAA

>43640_43640_1_KRT6A-SPINK5_KRT6A_chr12_52884641_ENST00000330722_SPINK5_chr5_147465967_ENST00000256084_length(amino acids)=1274AA_BP=983
MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGS
YGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDK
VRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTL
KKDVDAAYMNKVELQAKADTLTDEINFLRALYDALNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGE
CKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT
RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLC
SMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK
SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLIC
TREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNA
AGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ
MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPV
RGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEA
LERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS

--------------------------------------------------------------
>43640_43640_2_KRT6A-SPINK5_KRT6A_chr12_52884641_ENST00000330722_SPINK5_chr5_147465967_ENST00000359874_length(transcript)=4282nt_BP=981nt
AGTCCTGCTTCTCTTCCCTCTCTCCTCCAGCCTCTCACACTCTCCTCAGCTCTCTCATCTCCTGGAACCATGGCCAGCACATCCACCACC
ATCAGGAGCCACAGCAGCAGCCGCCGGGGTTTCAGTGCCAACTCAGCCAGGCTCCCTGGGGTCAGCCGCTCTGGCTTCAGCAGCGTCTCC
GTGTCCCGCTCCAGGGGCAGTGGTGGCCTGGGTGGTGCATGTGGAGGAGCTGGCTTTGGCAGCCGCAGTCTGTATGGCCTGGGGGGCTCC
AAGAGGATCTCCATTGGAGGGGGCAGCTGTGCCATCAGTGGCGGCTATGGCAGCAGAGCCGGAGGCAGCTATGGCTTTGGTGGCGCCGGG
AGTGGATTTGGTTTCGGTGGTGGAGCCGGCATTGGCTTTGGTCTGGGTGGTGGAGCCGGCCTTGCTGGTGGCTTTGGGGGCCCTGGCTTC
CCTGTGTGCCCCCCTGGAGGCATCCAAGAGGTCACCGTCAACCAGAGTCTCCTGACTCCCCTCAACCTGCAAATCGATCCCACCATCCAG
CGGGTGCGGGCTGAGGAGCGTGAACAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATCGACAAGGTGCGGTTCCTGGAGCAGCAG
AACAAGGTTCTGGAAACAAAGTGGACCCTGCTGCAGGAGCAGGGCACCAAGACTGTGAGGCAGAACCTGGAGCCGTTGTTCGAGCAGTAC
ATCAACAACCTCAGGAGGCAGCTGGACAGCATTGTCGGGGAACGGGGCCGCCTGGACTCAGAGCTCAGAGGCATGCAGGACCTGGTGGAG
GACTTCAAGAACAAATATGAGGATGAAATCAACAAGCGCACAGCAGCAGAGAATGAATTTGTGACTCTGAAGAAGGATGTGGATGCTGCC
TACATGAACAAGGTTGAACTGCAAGCCAAGGCAGACACTCTCACAGACGAGATCAACTTCCTGAGAGCCTTGTATGATGCACTGAATTGT
GATGATTTTAAAAAAGGAGAAAGAGATGGGGATTTTATCTGTCCTGATTATTATGAAGCTGTTTGTGGCACAGATGGGAAAACATATGAC
AACAGATGTGCACTGTGTGCTGAGAATGCGAAAACCGGGTCCCAAATTGGTGTAAAAAGTGAAGGGGAATGTAAGAGCAGTAATCCAGAG
CAGGATGTATGCAGTGCTTTTCGGCCCTTTGTTAGAGATGGAAGACTTGGATGCACAAGGGAAAATGATCCTGTTCTTGGTCCTGATGGG
AAGACGCATGGCAATAAGTGTGCAATGTGTGCTGAGCTGTTTTTAAAAGAAGCTGAAAATGCCAAGCGAGAGGGTGAAACTAGAATTCGA
CGAAATGCTGAAAAGGATTTTTGCAAGGAATATGAAAAACAAGTGAGAAATGGAAGGCTTTTTTGTACACGGGAGAGTGATCCAGTCCGT
GGCCCTGACGGCAGGATGCATGGCAACAAATGTGCCCTGTGTGCTGAAATTTTCAAGCAGCGTTTTTCAGAGGAAAACAGTAAAACAGAT
CAAAATTTGGGAAAAGCTGAAGAAAAAACTAAAGTTAAAAGAGAAATTGTGAAACTCTGCAGTCAATATCAAAATCAGGCAAAGAATGGA
ATACTTTTCTGTACCAGAGAAAATGACCCTATTCGTGGTCCAGATGGGAAAATGCATGGCAACTTGTGTTCCATGTGTCAAGCCTACTTC
CAAGCAGAAAATGAAGAAAAGAAAAAGGCTGAAGCACGAGCTAGAAACAAAAGAGAATCTGGAAAAGCAACCTCATATGCAGAGCTTTGC
AGTGAATATCGAAAGCTTGTGAGGAACGGAAAACTTGCTTGCACCAGAGAGAACGATCCTATCCAGGGCCCAGATGGGAAAGTGCATGGC
AACACCTGCTCCATGTGTGAGGTCTTCTTCCAAGCAGAAGAAGAAGAAAAGAAAAAGAAGGAAGGTAAATCAAGAAACAAAAGACAATCT
AAGAGTACAGCTTCCTTTGAGGAGTTGTGTAGTGAATACCGCAAATCCAGGAAAAACGGACGGCTTTTTTGCACCAGAGAGAATGACCCC
ATCCAGGGCCCAGATGGAAAAATGCATGGCAACACCTGCTCCATGTGTGAGGCCTTCTTTCAACAAGAAGAAAGAGCAAGAGCAAAGGCT
AAAAGAGAAGCTGCAAAGGAAATCTGCAGTGAATTTCGGGACCAAGTGAGGAATGGAACACTTATATGCACCAGGGAGCATAATCCTGTC
CGTGGCCCAGATGGCAAAATGCATGGAAACAAGTGTGCCATGTGTGCCAGTGTGTTCAAACTTGAAGAAGAAGAGAAGAAAAATGATAAA
GAAGAAAAAGGGAAAGTCGAGGCTGAAAAAGTTAAGAGAGAAGCAGTTCAGGAGCTGTGCAGTGAATATCGTCATTATGTGAGGAATGGA
CGACTCCCCTGTACCAGAGAGAATGATCCTATTGAGGGTCTAGATGGGAAAATCCACGGCAACACCTGCTCCATGTGTGAAGCCTTCTTC
CAGCAAGAAGCAAAAGAAAAAGAAAGAGCTGAACCCAGAGCAAAAGTCAAAAGAGAAGCTGAAAAGGAGACATGCGATGAATTTCGGAGA
CTTTTGCAAAATGGAAAACTTTTCTGCACAAGAGAAAATGATCCTGTGCGTGGCCCAGATGGCAAGACCCATGGCAACAAGTGTGCCATG
TGTAAGGCAGTCTTCCAGAAAGAAAATGAGGAAAGAAAGAGGAAAGAAGAGGAAGATCAGAGAAATGCTGCAGGACATGGTTCCAGTGGT
GGTGGAGGAGGAAACACTCAGGACGAATGTGCTGAGTATCGGGAACAAATGAAAAATGGAAGACTCAGCTGTACTCGGGAGAGTGATCCT
GTACGTGATGCTGATGGCAAATCGTACAACAATCAGTGTACCATGTGTAAAGCAAAATTGGAAAGAGAAGCAGAGAGAAAAAATGAGTAT
TCTCGCTCCAGATCAAATGGGACTGGATCAGAATCAGGGAAGGATACATGTGATGAGTTTAGAAGCCAAATGAAAAATGGAAAACTCATC
TGCACTCGAGAAAGTGACCCTGTCCGGGGTCCAGATGGCAAGACACATGGCAATAAGTGTACTATGTGTAAGGAAAAACTGGAAAGGGAA
GCAGCTGAAAAAAAAAAGAAAGAGGATGAAGACAGGAGCAATACAGGAGAAAGGAGCAATACAGGAGAAAGGAGCAATGACAAAGAGGAT
CTGTGTCGTGAATTTCGAAGCATGCAGAGAAATGGAAAGCTTATCTGCACCAGAGAAAATAACCCTGTTCGAGGCCCATATGGCAAGATG
CACATCAATAAATGTGCTATGTGTCAGAGCATCTTTGATCGAGAAGCTAATGAAAGAAAAAAGAAAGATGAAGAGAAATCAAGTAGCAAG
CCCTCAAATAATGCAAAGGACCAGTGCAGACAGGTTCAGAATGAAGCGGAGGATGCAAAATTTAGACAACCTGGGCGTTCCTTGGCCTCT
GTTGCCAGGATGAGTACAGATGAGTGCAGTGAATTTCGAAACTATATAAGGAACAATGAACTCATCTGCCCTAGAGAGAATGACCCAGTG
CACGGTGCTGATGGAAAGTTCTATACAAACAAGTGCTACATGTGCAGAGCTGTCTTTCTAACAGAAGCTTTGGAAAGGGCAAAGCTTCAA
GAAAAGCCATCCCATGTTAGAGCTTCTCAAGAGGAAGACAGCCCAGACTCTTTCAGTTCTCTGGATTCTGAGATGTGCAAAGACTACCGA
GTATTGCCCAGGATAGGTTATCTTTGTCCAAAGGATTTAAAGCCTGTCTGTGGTGACGATGGCCAAACCTACAACAATCCTTGCATGCTC
TGTCATGAAAACCTGATACGCCAAACAAATACACACATCCGCAGTACAGGGAAGTGTGAGGAGAGCAGCACCCCAGGAACCACCGCAGCC
AGCATGCCCCCGTCTGACGAATGACAGGAAGATTGTTGAAAGCCATGAGGGAAAAAATAAACCCCAGTTCTGAATCACCTACCTTCACCA
TCTGTATATACAAAGAATTCTTCGGAGCTTGTCTTATTTGCTATAGAAAACAATACAGAGCTTTTGGGAATGGACTCACTGATTTTCAGT
CTTTTCCATCTCTTTCCTCCTAGACTCTGTGATCTGAGGGTATAAAGACATCTCCACCAAGTCTGAGCCCTCAAAATGTCCTGATTACAA

>43640_43640_2_KRT6A-SPINK5_KRT6A_chr12_52884641_ENST00000330722_SPINK5_chr5_147465967_ENST00000359874_length(amino acids)=1304AA_BP=983
MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGS
YGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDK
VRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTL
KKDVDAAYMNKVELQAKADTLTDEINFLRALYDALNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGE
CKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT
RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLC
SMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK
SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLIC
TREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNA
AGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ
MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPV
RGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELIC
PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQT

--------------------------------------------------------------
>43640_43640_3_KRT6A-SPINK5_KRT6A_chr12_52884641_ENST00000330722_SPINK5_chr5_147465967_ENST00000398454_length(transcript)=3541nt_BP=981nt
AGTCCTGCTTCTCTTCCCTCTCTCCTCCAGCCTCTCACACTCTCCTCAGCTCTCTCATCTCCTGGAACCATGGCCAGCACATCCACCACC
ATCAGGAGCCACAGCAGCAGCCGCCGGGGTTTCAGTGCCAACTCAGCCAGGCTCCCTGGGGTCAGCCGCTCTGGCTTCAGCAGCGTCTCC
GTGTCCCGCTCCAGGGGCAGTGGTGGCCTGGGTGGTGCATGTGGAGGAGCTGGCTTTGGCAGCCGCAGTCTGTATGGCCTGGGGGGCTCC
AAGAGGATCTCCATTGGAGGGGGCAGCTGTGCCATCAGTGGCGGCTATGGCAGCAGAGCCGGAGGCAGCTATGGCTTTGGTGGCGCCGGG
AGTGGATTTGGTTTCGGTGGTGGAGCCGGCATTGGCTTTGGTCTGGGTGGTGGAGCCGGCCTTGCTGGTGGCTTTGGGGGCCCTGGCTTC
CCTGTGTGCCCCCCTGGAGGCATCCAAGAGGTCACCGTCAACCAGAGTCTCCTGACTCCCCTCAACCTGCAAATCGATCCCACCATCCAG
CGGGTGCGGGCTGAGGAGCGTGAACAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATCGACAAGGTGCGGTTCCTGGAGCAGCAG
AACAAGGTTCTGGAAACAAAGTGGACCCTGCTGCAGGAGCAGGGCACCAAGACTGTGAGGCAGAACCTGGAGCCGTTGTTCGAGCAGTAC
ATCAACAACCTCAGGAGGCAGCTGGACAGCATTGTCGGGGAACGGGGCCGCCTGGACTCAGAGCTCAGAGGCATGCAGGACCTGGTGGAG
GACTTCAAGAACAAATATGAGGATGAAATCAACAAGCGCACAGCAGCAGAGAATGAATTTGTGACTCTGAAGAAGGATGTGGATGCTGCC
TACATGAACAAGGTTGAACTGCAAGCCAAGGCAGACACTCTCACAGACGAGATCAACTTCCTGAGAGCCTTGTATGATGCACTGAATTGT
GATGATTTTAAAAAAGGAGAAAGAGATGGGGATTTTATCTGTCCTGATTATTATGAAGCTGTTTGTGGCACAGATGGGAAAACATATGAC
AACAGATGTGCACTGTGTGCTGAGAATGCGAAAACCGGGTCCCAAATTGGTGTAAAAAGTGAAGGGGAATGTAAGAGCAGTAATCCAGAG
CAGGATGTATGCAGTGCTTTTCGGCCCTTTGTTAGAGATGGAAGACTTGGATGCACAAGGGAAAATGATCCTGTTCTTGGTCCTGATGGG
AAGACGCATGGCAATAAGTGTGCAATGTGTGCTGAGCTGTTTTTAAAAGAAGCTGAAAATGCCAAGCGAGAGGGTGAAACTAGAATTCGA
CGAAATGCTGAAAAGGATTTTTGCAAGGAATATGAAAAACAAGTGAGAAATGGAAGGCTTTTTTGTACACGGGAGAGTGATCCAGTCCGT
GGCCCTGACGGCAGGATGCATGGCAACAAATGTGCCCTGTGTGCTGAAATTTTCAAGCAGCGTTTTTCAGAGGAAAACAGTAAAACAGAT
CAAAATTTGGGAAAAGCTGAAGAAAAAACTAAAGTTAAAAGAGAAATTGTGAAACTCTGCAGTCAATATCAAAATCAGGCAAAGAATGGA
ATACTTTTCTGTACCAGAGAAAATGACCCTATTCGTGGTCCAGATGGGAAAATGCATGGCAACTTGTGTTCCATGTGTCAAGCCTACTTC
CAAGCAGAAAATGAAGAAAAGAAAAAGGCTGAAGCACGAGCTAGAAACAAAAGAGAATCTGGAAAAGCAACCTCATATGCAGAGCTTTGC
AGTGAATATCGAAAGCTTGTGAGGAACGGAAAACTTGCTTGCACCAGAGAGAACGATCCTATCCAGGGCCCAGATGGGAAAGTGCATGGC
AACACCTGCTCCATGTGTGAGGTCTTCTTCCAAGCAGAAGAAGAAGAAAAGAAAAAGAAGGAAGGTAAATCAAGAAACAAAAGACAATCT
AAGAGTACAGCTTCCTTTGAGGAGTTGTGTAGTGAATACCGCAAATCCAGGAAAAACGGACGGCTTTTTTGCACCAGAGAGAATGACCCC
ATCCAGGGCCCAGATGGAAAAATGCATGGCAACACCTGCTCCATGTGTGAGGCCTTCTTTCAACAAGAAGAAAGAGCAAGAGCAAAGGCT
AAAAGAGAAGCTGCAAAGGAAATCTGCAGTGAATTTCGGGACCAAGTGAGGAATGGAACACTTATATGCACCAGGGAGCATAATCCTGTC
CGTGGCCCAGATGGCAAAATGCATGGAAACAAGTGTGCCATGTGTGCCAGTGTGTTCAAACTTGAAGAAGAAGAGAAGAAAAATGATAAA
GAAGAAAAAGGGAAAGTCGAGGCTGAAAAAGTTAAGAGAGAAGCAGTTCAGGAGCTGTGCAGTGAATATCGTCATTATGTGAGGAATGGA
CGACTCCCCTGTACCAGAGAGAATGATCCTATTGAGGGTCTAGATGGGAAAATCCACGGCAACACCTGCTCCATGTGTGAAGCCTTCTTC
CAGCAAGAAGCAAAAGAAAAAGAAAGAGCTGAACCCAGAGCAAAAGTCAAAAGAGAAGCTGAAAAGGAGACATGCGATGAATTTCGGAGA
CTTTTGCAAAATGGAAAACTTTTCTGCACAAGAGAAAATGATCCTGTGCGTGGCCCAGATGGCAAGACCCATGGCAACAAGTGTGCCATG
TGTAAGGCAGTCTTCCAGAAAGAAAATGAGGAAAGAAAGAGGAAAGAAGAGGAAGATCAGAGAAATGCTGCAGGACATGGTTCCAGTGGT
GGTGGAGGAGGAAACACTCAGGACGAATGTGCTGAGTATCGGGAACAAATGAAAAATGGAAGACTCAGCTGTACTCGGGAGAGTGATCCT
GTACGTGATGCTGATGGCAAATCGTACAACAATCAGTGTACCATGTGTAAAGCAAAATTGGAAAGAGAAGCAGAGAGAAAAAATGAGTAT
TCTCGCTCCAGATCAAATGGGACTGGATCAGAATCAGGGAAGGATACATGTGATGAGTTTAGAAGCCAAATGAAAAATGGAAAACTCATC
TGCACTCGAGAAAGTGACCCTGTCCGGGGTCCAGATGGCAAGACACATGGCAATAAGTGTACTATGTGTAAGGAAAAACTGGAAAGGGAA
GCAGCTGAAAAAAAAAAGAAAGAGGATGAAGACAGGAGCAATACAGGAGAAAGGAGCAATACAGGAGAAAGGAGCAATGACAAAGAGGAT
CTGTGTCGTGAATTTCGAAGCATGCAGAGAAATGGAAAGCTTATCTGCACCAGAGAAAATAACCCTGTTCGAGGCCCATATGGCAAGATG
CACATCAATAAATGTGCTATGTGTCAGAGCATCTTTGATCGAGAAGCTAATGAAAGAAAAAAGAAAGATGAAGAGAAATCAAGTAGCAAG
CCCTCAAATAATGCAAAGGTTATTTATTAAAGGATACCAAAATAACCATTTTACTTTTCACCTTCAGAATTTTGCATTCTTCTCCAGCTT

>43640_43640_3_KRT6A-SPINK5_KRT6A_chr12_52884641_ENST00000330722_SPINK5_chr5_147465967_ENST00000398454_length(amino acids)=1126AA_BP=983
MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGS
YGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDK
VRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTL
KKDVDAAYMNKVELQAKADTLTDEINFLRALYDALNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGE
CKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT
RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLC
SMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK
SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLIC
TREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNA
AGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ
MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for KRT6A-SPINK5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for KRT6A-SPINK5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for KRT6A-SPINK5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source