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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KRTCAP3-AVIL (FusionGDB2 ID:43712)

Fusion Gene Summary for KRTCAP3-AVIL

check button Fusion gene summary
Fusion gene informationFusion gene name: KRTCAP3-AVIL
Fusion gene ID: 43712
HgeneTgene
Gene symbol

KRTCAP3

AVIL

Gene ID

200634

10677

Gene namekeratinocyte associated protein 3advillin
SynonymsKCP3ADVIL|DOC6|NPHS21|p92
Cytomap

2p23.3

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionkeratinocyte-associated protein 3keratinocytes associated protein 3advillin
Modification date2020031320200313
UniProtAcc

Q53RY4

O75366

Ensembl transtripts involved in fusion geneENST00000288873, ENST00000407293, 
ENST00000543753, 		ENST00000550083, 
ENST00000257861, ENST00000537081, 
Fusion gene scores* DoF score2 X 1 X 2=420 X 12 X 9=2160
# samples 220
** MAII scorelog2(2/4*10)=2.32192809488736log2(20/2160*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KRTCAP3 [Title/Abstract] AND AVIL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKRTCAP3(27666399)-AVIL(58194995), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KRTCAP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AVIL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-A47BKRTCAP3chr2

27666399

+AVILchr12

58194995

-


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Fusion Gene ORF analysis for KRTCAP3-AVIL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000288873ENST00000550083KRTCAP3chr2

27666399

+AVILchr12

58194995

-
5CDS-intronENST00000407293ENST00000550083KRTCAP3chr2

27666399

+AVILchr12

58194995

-
5CDS-intronENST00000543753ENST00000550083KRTCAP3chr2

27666399

+AVILchr12

58194995

-
In-frameENST00000288873ENST00000257861KRTCAP3chr2

27666399

+AVILchr12

58194995

-
In-frameENST00000288873ENST00000537081KRTCAP3chr2

27666399

+AVILchr12

58194995

-
In-frameENST00000407293ENST00000257861KRTCAP3chr2

27666399

+AVILchr12

58194995

-
In-frameENST00000407293ENST00000537081KRTCAP3chr2

27666399

+AVILchr12

58194995

-
In-frameENST00000543753ENST00000257861KRTCAP3chr2

27666399

+AVILchr12

58194995

-
In-frameENST00000543753ENST00000537081KRTCAP3chr2

27666399

+AVILchr12

58194995

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000543753KRTCAP3chr227666399+ENST00000537081AVILchr1258194995-147166247970307
ENST00000543753KRTCAP3chr227666399+ENST00000257861AVILchr1258194995-97166247970308
ENST00000288873KRTCAP3chr227666399+ENST00000537081AVILchr1258194995-145664732955307
ENST00000288873KRTCAP3chr227666399+ENST00000257861AVILchr1258194995-95664732955308
ENST00000407293KRTCAP3chr227666399+ENST00000537081AVILchr1258194995-15297201561028290
ENST00000407293KRTCAP3chr227666399+ENST00000257861AVILchr1258194995-10297201561028290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000543753ENST00000537081KRTCAP3chr227666399+AVILchr1258194995-0.0033968720.99660313
ENST00000543753ENST00000257861KRTCAP3chr227666399+AVILchr1258194995-0.0056716910.9943283
ENST00000288873ENST00000537081KRTCAP3chr227666399+AVILchr1258194995-0.0037972780.99620277
ENST00000288873ENST00000257861KRTCAP3chr227666399+AVILchr1258194995-0.0060000970.99399996
ENST00000407293ENST00000537081KRTCAP3chr227666399+AVILchr1258194995-0.0017922020.9982078
ENST00000407293ENST00000257861KRTCAP3chr227666399+AVILchr1258194995-0.003707040.9962929

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Fusion Genomic Features for KRTCAP3-AVIL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KRTCAP3-AVIL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:27666399/chr12:58194995)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRTCAP3

Q53RY4

AVIL

O75366

FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling (PubMed:29058690). May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (PubMed:29058690). {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000288873+57163_183205258.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000288873+5721_41205258.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000288873+5763_83205258.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000288873+5794_114205258.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000407293+46163_183187153.33333333333334TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000407293+4621_41187153.33333333333334TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000407293+4663_83187153.33333333333334TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000407293+4694_114187153.33333333333334TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000543753+57163_183205276.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000543753+5721_41205276.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000543753+5763_83205276.3333333333333TransmembraneHelical
HgeneKRTCAP3chr2:27666399chr12:58194995ENST00000543753+5794_114205276.3333333333333TransmembraneHelical
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519753_819717820.0DomainHP
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519753_819710813.0DomainHP
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519731_819717820.0RegionHeadpiece
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519731_819710813.0RegionHeadpiece

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519109_116717820.0RegionPolyphosphoinositide binding
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519135_143717820.0RegionPolyphosphoinositide binding
TgeneAVILchr2:27666399chr12:58194995ENST0000025786115191_731717820.0RegionCore
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519109_116710813.0RegionPolyphosphoinositide binding
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519135_143710813.0RegionPolyphosphoinositide binding
TgeneAVILchr2:27666399chr12:58194995ENST0000053708115191_731710813.0RegionCore
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519145_185717820.0RepeatNote=Gelsolin-like 2
TgeneAVILchr2:27666399chr12:58194995ENST00000257861151924_73717820.0RepeatNote=Gelsolin-like 1
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519262_306717820.0RepeatNote=Gelsolin-like 3
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519403_454717820.0RepeatNote=Gelsolin-like 4
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519525_565717820.0RepeatNote=Gelsolin-like 5
TgeneAVILchr2:27666399chr12:58194995ENST000002578611519628_669717820.0RepeatNote=Gelsolin-like 6
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519145_185710813.0RepeatNote=Gelsolin-like 2
TgeneAVILchr2:27666399chr12:58194995ENST00000537081151924_73710813.0RepeatNote=Gelsolin-like 1
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519262_306710813.0RepeatNote=Gelsolin-like 3
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519403_454710813.0RepeatNote=Gelsolin-like 4
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519525_565710813.0RepeatNote=Gelsolin-like 5
TgeneAVILchr2:27666399chr12:58194995ENST000005370811519628_669710813.0RepeatNote=Gelsolin-like 6


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Fusion Gene Sequence for KRTCAP3-AVIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43712_43712_1_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000288873_AVIL_chr12_58194995_ENST00000257861_length(transcript)=956nt_BP=647nt
ACAGCGGCCCTGCGGCTGGCGCGGCGGACGGGATGAGGCGCTGCAGTCTCTGCGCTTTCGACGCCGCCCGGGGGCCCAGGCGGCTGATGC
GTGTGGGCCTCGCGCTGATCTTGGTGGGCCACGTGAACCTGCTGCTGGGGGCCGTGCTGCATGGCACCGTCCTGCGGCACGTGGCCAATC
CCCGCGGCGCTGTCACGCCGGAGTACACCGTAGCCAATGTCATCTCTGTCGGCTCGGGGCTGCTGAGCGTTTCCGTGGGACTTGTGGCCC
TCCTGGCGTCCAGGAACCTTCTTCGCCCTCCACTGCACTGGGTCCTGCTGGCACTAGCTCTGGTGAACCTGCTCTTGTCCGTTGCCTGCT
CCCTGGGCCTCCTTCTTGCTGTGTCACTCACTGTGGCCAACGGTGGCCGCCGCCTTATTGCTGACTGCCACCCAGGACTGCTGGATCCTC
TGGTACCACTGGATGAGGGGCCGGGACATACTGACTGCCCCTTTGACCCCACAAGAATCTATGATACAGCCTTGGCTCTCTGGATCCCTT
CTTTGCTCATGTCTGCAGGGGAGGCTGCTCTATCTGGTTACTGCTGTGTGGCTGCACTCACTCTACGTGGAGTTGGGCCCTGCAGGAAGG
ACGGACTTCAGGGGCAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACA
TGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGC
TGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTG

>43712_43712_1_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000288873_AVIL_chr12_58194995_ENST00000257861_length(amino acids)=308AA_BP=204
MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPP
LHWVLLALALVNLLLSVACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAAL
SGYCCVAALTLRGVGPCRKDGLQGQAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKE

--------------------------------------------------------------
>43712_43712_2_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000288873_AVIL_chr12_58194995_ENST00000537081_length(transcript)=1456nt_BP=647nt
ACAGCGGCCCTGCGGCTGGCGCGGCGGACGGGATGAGGCGCTGCAGTCTCTGCGCTTTCGACGCCGCCCGGGGGCCCAGGCGGCTGATGC
GTGTGGGCCTCGCGCTGATCTTGGTGGGCCACGTGAACCTGCTGCTGGGGGCCGTGCTGCATGGCACCGTCCTGCGGCACGTGGCCAATC
CCCGCGGCGCTGTCACGCCGGAGTACACCGTAGCCAATGTCATCTCTGTCGGCTCGGGGCTGCTGAGCGTTTCCGTGGGACTTGTGGCCC
TCCTGGCGTCCAGGAACCTTCTTCGCCCTCCACTGCACTGGGTCCTGCTGGCACTAGCTCTGGTGAACCTGCTCTTGTCCGTTGCCTGCT
CCCTGGGCCTCCTTCTTGCTGTGTCACTCACTGTGGCCAACGGTGGCCGCCGCCTTATTGCTGACTGCCACCCAGGACTGCTGGATCCTC
TGGTACCACTGGATGAGGGGCCGGGACATACTGACTGCCCCTTTGACCCCACAAGAATCTATGATACAGCCTTGGCTCTCTGGATCCCTT
CTTTGCTCATGTCTGCAGGGGAGGCTGCTCTATCTGGTTACTGCTGTGTGGCTGCACTCACTCTACGTGGAGTTGGGCCCTGCAGGAAGG
ACGGACTTCAGGGGCAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACA
TGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGC
TGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTG
CAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAG
AAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCT
GCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTT
TGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTT
AAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCC
TGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAAGCATTTTTCACTTTTCAAAT

>43712_43712_2_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000288873_AVIL_chr12_58194995_ENST00000537081_length(amino acids)=307AA_BP=204
MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPP
LHWVLLALALVNLLLSVACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAAL
SGYCCVAALTLRGVGPCRKDGLQGQAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKE

--------------------------------------------------------------
>43712_43712_3_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000407293_AVIL_chr12_58194995_ENST00000257861_length(transcript)=1029nt_BP=720nt
TTCCGGGCCCTGGCGTCTCGTCTCCTTACCCTGGGGCTACCCTTGCCCCGTCCTACTGCCCGCGGTTAACCCGCCGCGAGCCGCCTCTCC
CCTCCCCGCCCGACTCAACCCTGCCCTCCCCCGTGCTTTGCAGACGCCGCCCGGGGGCCCAGGCGGCTGATGCGTGTGGGCCTCGCGCTG
ATCTTGGTGGGCCACGTGAACCTGCTGCTGGGGGCCGTGCTGCATGGCACCGTCCTGCGGCACGTGGCCAATCCCCGCGGCGCTGTCACG
CCGGAGTACACCGTAGCCAATGTCATCTCTGTCGGCTCGGGGCTGCTGAGCGTTTCCGTGGGACTTGTGGCCCTCCTGGCGTCCAGGAAC
CTTCTTCGCCCTCCACTGCACTGGGTCCTGCTGGCACTAGCTCTGGTGAACCTGCTCTTGTCCGTTGCCTGCTCCCTGGGCCTCCTTCTT
GCTGTGTCACTCACTGTGGCCAACGGTGGCCGCCGCCTTATTGCTGACTGCCACCCAGGACTGCTGGATCCTCTGGTACCACTGGATGAG
GGGCCGGGACATACTGACTGCCCCTTTGACCCCACAAGAATCTATGATACAGCCTTGGCTCTCTGGATCCCTTCTTTGCTCATGTCTGCA
GGGGAGGCTGCTCTATCTGGTTACTGCTGTGTGGCTGCACTCACTCTACGTGGAGTTGGGCCCTGCAGGAAGGACGGACTTCAGGGGCAG
GCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTC
TCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAAC
CCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGG

>43712_43712_3_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000407293_AVIL_chr12_58194995_ENST00000257861_length(amino acids)=290AA_BP=187
MMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPPLHWVLLALALVNLLLSV
ACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAALSGYCCVAALTLRGVGPC
RKDGLQGQAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

--------------------------------------------------------------
>43712_43712_4_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000407293_AVIL_chr12_58194995_ENST00000537081_length(transcript)=1529nt_BP=720nt
TTCCGGGCCCTGGCGTCTCGTCTCCTTACCCTGGGGCTACCCTTGCCCCGTCCTACTGCCCGCGGTTAACCCGCCGCGAGCCGCCTCTCC
CCTCCCCGCCCGACTCAACCCTGCCCTCCCCCGTGCTTTGCAGACGCCGCCCGGGGGCCCAGGCGGCTGATGCGTGTGGGCCTCGCGCTG
ATCTTGGTGGGCCACGTGAACCTGCTGCTGGGGGCCGTGCTGCATGGCACCGTCCTGCGGCACGTGGCCAATCCCCGCGGCGCTGTCACG
CCGGAGTACACCGTAGCCAATGTCATCTCTGTCGGCTCGGGGCTGCTGAGCGTTTCCGTGGGACTTGTGGCCCTCCTGGCGTCCAGGAAC
CTTCTTCGCCCTCCACTGCACTGGGTCCTGCTGGCACTAGCTCTGGTGAACCTGCTCTTGTCCGTTGCCTGCTCCCTGGGCCTCCTTCTT
GCTGTGTCACTCACTGTGGCCAACGGTGGCCGCCGCCTTATTGCTGACTGCCACCCAGGACTGCTGGATCCTCTGGTACCACTGGATGAG
GGGCCGGGACATACTGACTGCCCCTTTGACCCCACAAGAATCTATGATACAGCCTTGGCTCTCTGGATCCCTTCTTTGCTCATGTCTGCA
GGGGAGGCTGCTCTATCTGGTTACTGCTGTGTGGCTGCACTCACTCTACGTGGAGTTGGGCCCTGCAGGAAGGACGGACTTCAGGGGCAG
GCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGCGAATCACTGCTGACATGAAGAATGCAACCCTC
TCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAAC
CCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGG
AAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGC
CAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTT
CTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAA
AGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTT
TATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATC

>43712_43712_4_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000407293_AVIL_chr12_58194995_ENST00000537081_length(amino acids)=290AA_BP=187
MMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPPLHWVLLALALVNLLLSV
ACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAALSGYCCVAALTLRGVGPC
RKDGLQGQAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

--------------------------------------------------------------
>43712_43712_5_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000543753_AVIL_chr12_58194995_ENST00000257861_length(transcript)=971nt_BP=662nt
GGGCCGGGCCCAGGTACAGCGGCCCTGCGGCTGGCGCGGCGGACGGGATGAGGCGCTGCAGTCTCTGCGCTTTCGACGCCGCCCGGGGGC
CCAGGCGGCTGATGCGTGTGGGCCTCGCGCTGATCTTGGTGGGCCACGTGAACCTGCTGCTGGGGGCCGTGCTGCATGGCACCGTCCTGC
GGCACGTGGCCAATCCCCGCGGCGCTGTCACGCCGGAGTACACCGTAGCCAATGTCATCTCTGTCGGCTCGGGGCTGCTGAGCGTTTCCG
TGGGACTTGTGGCCCTCCTGGCGTCCAGGAACCTTCTTCGCCCTCCACTGCACTGGGTCCTGCTGGCACTAGCTCTGGTGAACCTGCTCT
TGTCCGTTGCCTGCTCCCTGGGCCTCCTTCTTGCTGTGTCACTCACTGTGGCCAACGGTGGCCGCCGCCTTATTGCTGACTGCCACCCAG
GACTGCTGGATCCTCTGGTACCACTGGATGAGGGGCCGGGACATACTGACTGCCCCTTTGACCCCACAAGAATCTATGATACAGCCTTGG
CTCTCTGGATCCCTTCTTTGCTCATGTCTGCAGGGGAGGCTGCTCTATCTGGTTACTGCTGTGTGGCTGCACTCACTCTACGTGGAGTTG
GGCCCTGCAGGAAGGACGGACTTCAGGGGCAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGC
GAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAA
ACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCA

>43712_43712_5_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000543753_AVIL_chr12_58194995_ENST00000257861_length(amino acids)=308AA_BP=204
MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPP
LHWVLLALALVNLLLSVACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAAL
SGYCCVAALTLRGVGPCRKDGLQGQAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKE

--------------------------------------------------------------
>43712_43712_6_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000543753_AVIL_chr12_58194995_ENST00000537081_length(transcript)=1471nt_BP=662nt
GGGCCGGGCCCAGGTACAGCGGCCCTGCGGCTGGCGCGGCGGACGGGATGAGGCGCTGCAGTCTCTGCGCTTTCGACGCCGCCCGGGGGC
CCAGGCGGCTGATGCGTGTGGGCCTCGCGCTGATCTTGGTGGGCCACGTGAACCTGCTGCTGGGGGCCGTGCTGCATGGCACCGTCCTGC
GGCACGTGGCCAATCCCCGCGGCGCTGTCACGCCGGAGTACACCGTAGCCAATGTCATCTCTGTCGGCTCGGGGCTGCTGAGCGTTTCCG
TGGGACTTGTGGCCCTCCTGGCGTCCAGGAACCTTCTTCGCCCTCCACTGCACTGGGTCCTGCTGGCACTAGCTCTGGTGAACCTGCTCT
TGTCCGTTGCCTGCTCCCTGGGCCTCCTTCTTGCTGTGTCACTCACTGTGGCCAACGGTGGCCGCCGCCTTATTGCTGACTGCCACCCAG
GACTGCTGGATCCTCTGGTACCACTGGATGAGGGGCCGGGACATACTGACTGCCCCTTTGACCCCACAAGAATCTATGATACAGCCTTGG
CTCTCTGGATCCCTTCTTTGCTCATGTCTGCAGGGGAGGCTGCTCTATCTGGTTACTGCTGTGTGGCTGCACTCACTCTACGTGGAGTTG
GGCCCTGCAGGAAGGACGGACTTCAGGGGCAGGCAGGAAAAACATATGAACAATTAAAAGAAGAGCTGGGAGATGCTGCTGCTATCATGC
GAATCACTGCTGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAA
ACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCA
CAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAGAAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCT
ATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATCCACCAATTTCTGCCTGACATTCAGCTACTTAATTTA
GATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGCATTCCTTGCTTGTTATATACCTAAAATGTTAACCAT
ATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAAACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAAC
CAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGACCTACCTTTGTTTTCAATTTTAAGATGATTATTTCT
AAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAAATCCAAATACCCAGATCTGTAATGTGTCAAAGCATT

>43712_43712_6_KRTCAP3-AVIL_KRTCAP3_chr2_27666399_ENST00000543753_AVIL_chr12_58194995_ENST00000537081_length(amino acids)=307AA_BP=204
MRRCSLCAFDAARGPRRLMRVGLALILVGHVNLLLGAVLHGTVLRHVANPRGAVTPEYTVANVISVGSGLLSVSVGLVALLASRNLLRPP
LHWVLLALALVNLLLSVACSLGLLLAVSLTVANGGRRLIADCHPGLLDPLVPLDEGPGHTDCPFDPTRIYDTALALWIPSLLMSAGEAAL
SGYCCVAALTLRGVGPCRKDGLQGQAGKTYEQLKEELGDAAAIMRITADMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for KRTCAP3-AVIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KRTCAP3-AVIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KRTCAP3-AVIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource