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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:KTN1-CCT5 (FusionGDB2 ID:43742)

Fusion Gene Summary for KTN1-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: KTN1-CCT5
Fusion gene ID: 43742
HgeneTgene
Gene symbol

KTN1

CCT5

Gene ID

3895

22948

Gene namekinectin 1chaperonin containing TCP1 subunit 5
SynonymsCG1|KNT|MU-RMS-40.19CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

14q22.3

5p15.2

Type of geneprotein-codingprotein-coding
DescriptionkinectinCG-1 antigenkinesin receptorT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020031320200313
UniProtAcc

Q86UP2

P48643

Ensembl transtripts involved in fusion geneENST00000395311, ENST00000395314, 
ENST00000413890, ENST00000416613, 
ENST00000438792, ENST00000395308, 
ENST00000395309, ENST00000554507, 
ENST00000555573, 		ENST00000503026, 
ENST00000506600, ENST00000515390, 
ENST00000515676, ENST00000280326, 
Fusion gene scores* DoF score17 X 19 X 8=258458 X 14 X 17=13804
# samples 2061
** MAII scorelog2(20/2584*10)=-3.6915341649192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KTN1 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointKTN1(56151301)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.KTN1-CCT5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KTN1-CCT5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KTN1-CCT5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5K5-01AKTN1chr14

56151301

-CCT5chr5

10250033

+


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Fusion Gene ORF analysis for KTN1-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000395311ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395311ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395311ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395311ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395314ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395314ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395314ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000395314ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000413890ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000413890ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000413890ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000413890ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000416613ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000416613ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000416613ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000416613ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000438792ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000438792ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000438792ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
5CDS-intronENST00000438792ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
Frame-shiftENST00000395311ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
Frame-shiftENST00000395314ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
Frame-shiftENST00000416613ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
Frame-shiftENST00000438792ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
In-frameENST00000413890ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-3CDSENST00000395308ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-3CDSENST00000395309ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-3CDSENST00000554507ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-3CDSENST00000555573ENST00000280326KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395308ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395308ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395308ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395308ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395309ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395309ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395309ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000395309ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000554507ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000554507ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000554507ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000554507ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000555573ENST00000503026KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000555573ENST00000506600KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000555573ENST00000515390KTN1chr14

56151301

-CCT5chr5

10250033

+
intron-intronENST00000555573ENST00000515676KTN1chr14

56151301

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413890KTN1chr1456151301-ENST00000280326CCT5chr510250033+8254457917840981306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413890ENST00000280326KTN1chr1456151301-CCT5chr510250033+0.0003974990.9996025

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Fusion Genomic Features for KTN1-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for KTN1-CCT5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:56151301/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KTN1

Q86UP2

CCT5

P48643

FUNCTION: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKTN1chr14:56151301chr5:10250033ENST00000395311-4242330_135614651307.0Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000395314-4444330_135615161358.0Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000413890-4242330_135614671307.0Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000416613-4444330_135615361321.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000438792-4242330_135614591301.0Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000395311-42421_614651307.0Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000395311-424230_135714651307.0Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000395314-44441_615161358.0Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000395314-444430_135715161358.0Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000413890-42421_614671307.0Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000413890-424230_135714671307.0Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000416613-44441_615361321.3333333333333Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000416613-444430_135715361321.3333333333333Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000438792-42421_614591301.0Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000438792-424230_135714591301.0Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000395311-42427_2914651307.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneKTN1chr14:56151301chr5:10250033ENST00000395314-44447_2915161358.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneKTN1chr14:56151301chr5:10250033ENST00000413890-42427_2914671307.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneKTN1chr14:56151301chr5:10250033ENST00000416613-44447_2915361321.3333333333333TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneKTN1chr14:56151301chr5:10250033ENST00000438792-42427_2914591301.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKTN1chr14:56151301chr5:10250033ENST00000395308-143330_135601307.0Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000395309-144330_135601358.0Coiled coilOntology_term=ECO:0000255
HgeneKTN1chr14:56151301chr5:10250033ENST00000395308-1431_601307.0Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000395308-14330_135701307.0Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000395309-1441_601358.0Topological domainCytoplasmic
HgeneKTN1chr14:56151301chr5:10250033ENST00000395309-14430_135701358.0Topological domainLumenal
HgeneKTN1chr14:56151301chr5:10250033ENST00000395308-1437_2901307.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneKTN1chr14:56151301chr5:10250033ENST00000395309-1447_2901358.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for KTN1-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43742_43742_1_KTN1-CCT5_KTN1_chr14_56151301_ENST00000413890_CCT5_chr5_10250033_ENST00000280326_length(transcript)=8254nt_BP=4579nt
GAAGCCGCCCGTTTCCTGCCGAGCGGCGCGACGGCACCTGAGCGACTGCGGCGGCGGCGGCGGCGGCGGCGGCGCCTCGGAGCGGGCGGC
CCGGGCTGTAGTGCCGGCGCCGCCGCGTCTTCCCGGTCTCCTTTCCCGGCCGCACAGGGTTTTATAGGATCACATTGACAAAAGTACCAT
GGAGTTTTATGAGTCAGCATATTTTATTGTTCTTATTCCTTCAATAGTTATTACAGTAATTTTCCTCTTCTTCTGGCTTTTCATGAAAGA
AACATTATATGATGAAGTTCTTGCAAAACAGAAAAGAGAACAAAAGCTTATTCCTACCAAAACAGATAAAAAGAAAGCAGAAAAGAAAAA
GAATAAAAAGAAAGAAATCCAGAATGGAAACCTCCATGAATCCGACTCTGAGAGTGTACCTCGAGACTTTAAATTATCAGATGCTTTGGC
AGTAGAAGATGATCAAGTTGCACCTGTTCCATTGAATGTCGTTGAAACTTCAAGTAGTGTTAGGGAAAGAAAAAAGAAGGAAAAGAAACA
AAAGCCTGTGCTTGAAGAGCAGGTCATCAAAGAAAGTGACGCATCAAAGATTCCTGGCAAAAAAGTAGAACCTGTCCCAGTTACTAAACA
GCCCACCCCTCCCTCTGAAGCAGCTGCCTCGAAGAAGAAACCAGGGCAGAAGAAGTCTAAAAATGGAAGCGATGACCAGGATAAAAAGGT
GGAAACTCTCATGGTACCATCAAAAAGGCAAGAAGCATTGCCCCTCCACCAAGAGACTAAACAAGAAAGTGGATCAGGGAAGAAGAAAGC
TTCATCAAAGAAACAAAAGACAGAAAATGTCTTCGTAGATGAACCCCTTATTCATGCAACTACTTATATTCCTTTGATGGATAATGCTGA
CTCAAGTCCTGTGGTAGATAAGAGAGAGGTTATTGATTTGCTTAAACCTGACCAAGTAGAAGGGATCCAGAAATCTGGGACTAAAAAACT
GAAGACCGAAACTGACAAAGAAAATGCTGAAGTGAAGTTTAAAGATTTTCTTCTGTCCTTGAAGACTATGATGTTTTCTGAAGATGAGGC
TCTTTGTGTTGTAGACTTGCTAAAGGAGAAGTCTGGTGTAATACAAGATGCTTTAAAGAAGTCAAGTAAGGGAGAATTGACTACGCTTAT
ACATCAGCTTCAAGAAAAGGACAAGTTACTCGCTGCTGTGAAGGAAGATGCTGCTGCTACAAAGGATCGGTGTAAGCAGTTAACCCAGGA
AATGATGACAGAGAAAGAAAGAAGCAATGTGGTTATAACAAGGATGAAAGATCGAATTGGAACATTAGAAAAGGAACATAATGTATTTCA
AAACAAAATACATGTCAGTTATCAAGAGACTCAACAGATGCAGATGAAGTTTCAGCAAGTTCGTGAGCAGATGGAGGCAGAGATAGCTCA
CTTGAAGCAGGAAAATGGTATACTGAGAGATGCAGTCAGCAACACTACAAATCAACTGGAAAGCAAGCAGTCTGCAGAACTAAATAAACT
ACGCCAGGATTATGCTAGGTTGGTGAATGAGCTGACTGAGAAAACAGGAAAGCTACAGCAAGAGGAAGTCCAAAAGAAGAATGCTGAGCA
AGCAGCTACTCAGTTGAAGGTTCAACTACAAGAAGCTGAGAGAAGGTGGGAAGAAGTTCAGAGCTACATCAGGAAGAGAACAGCGGAACA
TGAGGCAGCACAGCAAGATTTACAGAGTAAATTTGTGGCCAAAGAAAATGAAGTACAGAGTCTGCATAGTAAGCTTACAGATACCTTGGT
ATCAAAACAACAGTTGGAGCAAAGACTAATGCAGTTAATGGAATCAGAGCAGAAAAGGGTGAACAAAGAAGAGTCTCTACAAATGCAGGT
TCAGGATATTTTGGAGCAGAATGAGGCTTTGAAAGCTCAAATTCAGCAGTTCCATTCCCAGATAGCAGCCCAGACCTCCGCTTCAGTTCT
AGCAGAAGAATTACATAAAGTGATTGCAGAAAAGGATAAGCAGATAAAACAGACTGAAGATTCTTTAGCAAGTGAACGTGATCGTTTAAC
AAGTAAAGAAGAGGAACTTAAGGATATACAGAATATGAATTTCTTATTAAAAGCTGAAGTGCAGAAATTACAGGCCCTGGCAAATGAGCA
GGCTGCTGCTGCACATGAATTGGAGAAGATGCAACAAAGTGTTTATGTTAAAGATGATAAAATAAGATTGCTGGAAGAGCAACTACAACA
TGAAATTTCAAACAAAATGGAAGAATTTAAGATTCTAAATGACCAAAACAAAGCATTAAAATCAGAAGTTCAGAAGCTACAGACTCTTGT
TTCTGAACAGCCTAATAAGGATGTTGTGGAACAAATGGAAAAATGCATTCAAGAAAAAGATGAGAAGTTAAAGACTGTGGAAGAATTACT
TGAAACTGGACTTATTCAGGTGGCAACTAAAGAAGAGGAGCTGAATGCAATAAGAACAGAAAATTCATCTCTGACAAAAGAAGTTCAAGA
CTTAAAAGCTAAGCAAAATGATCAGGTTTCTTTTGCCTCTCTAGTTGAAGAACTTAAGAAAGTGATCCATGAGAAAGATGGAAAGATCAA
GTCTGTAGAAGAGCTTCTGGAGGCAGAACTTCTCAAAGTTGCTAACAAGGAGAAAACTGTTCAGTTATCTATCACTTCCAAAGTTCAGGA
GCTTCAGAACTTATTAAAAGGAAAAGAGGAACAGATGAATACCATGAAGGCTGTTTTGGAAGAGAAAGAGAAAGACCTAGCCAATACAGG
GAAGTGGTTACAGGATCTTCAAGAAGAAAATGAATCTTTAAAAGCACATGTTCAGGAAGTAGCACAACATAACTTGAAAGAGGCCTCTTC
TGCATCACAGTTTGAAGAACTTGAGATTGTGTTGAAAGAAAAGGAAAATGAATTGAAGAGGTTAGAAGCCATGCTAAAAGAGAGGGAGAG
TGATCTTTCTAGCAAAACACAGCTGTTACAGGATGTACAAGATGAAAACAAATTGTTTAAGTCCCAAATTGAGCAGCTTAAACAACAAAA
CTACCAACAGGCATCTTCTTTTCCCCCTCATGAAGAATTATTAAAAGTAATTTCAGAAAGAGAGAAAGAAATAAGTGGTCTCTGGAATGA
GTTAGATTCTTTGAAGGATGCAGTTGAACACCAGAGGAAGAAAAACAATGACCTTCGGGAGAAAAACTGGGAAGCAATGGAAGCATTGGC
ATCAACTGAAAAAATGCTGCAGGACAAAGTGAACAAGACTTCCAAGGAAAGGCAGCAACAGGTGGAAGCTGTTGAGTTGGAGGCTAAAGA
AGTTCTCAAAAAATTATTTCCAAAGGTGTCTGTCCCTTCTAATTTGAGTTATGGTGAATGGTTGCATGGATTTGAAAAAAAGGCAAAAGA
ATGTATGGCTGGAACTTCAGGGTCAGAGGAGGTTAAGGTTCTAGAGCACAAGTTGAAAGAAGCTGATGAAATGCACACATTGTTACAGCT
AGAGTGTGAAAAATACAAATCCGTCCTTGCAGAAACAGAAGGAATTTTACAGAAGCTACAGAGAAGTGTTGAGCAAGAAGAAAATAAATG
GAAAGTTAAGGTCGATGAATCACACAAGACTATTAAACAGATGCAGTCATCATTTACATCTTCAGAACAAGAGCTAGAGCGATTAAGAAG
CGAAAATAAGGATATTGAAAATCTGAGAAGAGAACGAGAACATTTGGAAATGGAACTAGAAAAGGCAGAGATGGAACGATCTACCTATGT
TACAGAAGTCAGAGAGTTGAAGGCACAGTTAAATGAAACACTCACAAAACTTAGAACTGAACAAAATGAAAGACAGAAGGTAGCTGGTGA
TTTGCATAAGGCTCAACAGTCACTGGAGCTTATCCAGTCAAAAATAGTAAAAGCTGCTGGAGACACTACTGTTATTGAAAATAGTGATGT
TTCCCCAGAAACGGAGTCTTCTGAGAAGGAGACAATGTCTGTAAGTCTAAATCAGACTGTAACACAGTTACAGCAGTTGCTTCAGGCGGT
AAACCAACAGCTCACAAAGGAGAAAGAGCACTACCAGGTGTTAGAGTGAAGTAATTGGGAAACTGTTCATTTGAGGATAAAAAAGGCATT
GTATTATATTTTGCCAAATTAAAGCCTTATTTATGTTTTCACCCTTTCTACTTTGTCAGAAACACTGAACAGAGTTTTGTCTTTTCTAAT
CCTTGTTAGACTACTGATTTAAAGAAGGAAAAAAAAAAGCCAACTCTGTAGACACCTTCAGAGTTTAGTTTTATAATAAAAACTGTTTGA
ATAATTAGACCTTTACATTCCTGAAGATAAACATGTAATCTTTTATCTTATTTTGCTCAATAAAATTGTTCAGAAGATCAAAGTGGTAAA
GACAATGTAAAATTTAACATTTTAATACTGATGTTGTACACTGTTTTACTTAACATTTTGGGAAGTAACTGCCTCTGACTTCAACTCAAG
AAAACACTTTTTTGTTGCTAATGTAATCGGTTTTTGTAATGGCGTCAGCAAATAAAAGGATGCTTATTATTCAAACTTGAAAAAAAAAAA
AAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGA
CCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAG
TGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTA
GTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTT
CCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCG
CCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGT
AGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGG
GGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGA
TGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGC
CGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACC
CCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCT
CACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACT
GATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCC
ATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAA
ATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACT
TCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAG
GTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCAT
CGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGA
TGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAG
CCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGA
AAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTT
GCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGT
TAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTC
TGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAAT
AGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAG
AATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTG
GGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAA
TATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTT
ACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACC
CTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTC
CCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGA
CTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGA
CAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGT
AGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTT
TCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAG
AATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAA
CTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAAT
CTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTAC
AGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTC
CAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTG

>43742_43742_1_KTN1-CCT5_KTN1_chr14_56151301_ENST00000413890_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=1306AA_BP=
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN
ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK
ECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR
SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD

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Fusion Gene PPI Analysis for KTN1-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for KTN1-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for KTN1-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource