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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:L2HGDH-SOS2 (FusionGDB2 ID:43792)

Fusion Gene Summary for L2HGDH-SOS2

Fusion gene summary

Fusion gene information	Fusion gene name: L2HGDH-SOS2
	Fusion gene ID: 43792
		Hgene	Tgene
	Gene symbol	L2HGDH	SOS2
	Gene ID	79944	6655
	Gene name	L-2-hydroxyglutarate dehydrogenase	SOS Ras/Rho guanine nucleotide exchange factor 2
	Synonyms	C14orf160\|L2HGA	NS9\|SOS-2
	Cytomap	14q21.3	14q21.3
	Type of gene	protein-coding	protein-coding
	Description	L-2-hydroxyglutarate dehydrogenase, mitochondrial2-hydroxyglutarate dehydrogenaseL-alpha-hydroxyglutarate dehydrogenasealpha-hydroxyglutarate oxidoreductasealpha-ketoglutarate reductaseduranin	son of sevenless homolog 2guanine nucleotide releasing factor
	Modification date	20200313	20200327
	UniProtAcc	Q9H9P8	.
	Ensembl transtripts involved in fusion gene	ENST00000261699, ENST00000267436, ENST00000421284, ENST00000555423, ENST00000555610, ENST00000556393,	ENST00000555794, ENST00000543680, ENST00000216373,
Fusion gene scores	* DoF score	10 X 9 X 5=450	13 X 13 X 9=1521
	# samples	10	17
	** MAII score	log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1521*10)=-3.16141350158679 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: L2HGDH [Title/Abstract] AND SOS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	L2HGDH(50778729)-SOS2(50641270), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	L2HGDH	GO:0044267	cellular protein metabolic process	16005139

Fusion gene breakpoints across L2HGDH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SOS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-A8PE-01A	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-

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Fusion Gene ORF analysis for L2HGDH-SOS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000261699	ENST00000555794	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-5UTR	ENST00000267436	ENST00000555794	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-5UTR	ENST00000421284	ENST00000555794	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-5UTR	ENST00000555423	ENST00000555794	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-5UTR	ENST00000555610	ENST00000555794	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-intron	ENST00000261699	ENST00000543680	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-intron	ENST00000267436	ENST00000543680	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-intron	ENST00000421284	ENST00000543680	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-intron	ENST00000555423	ENST00000543680	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5CDS-intron	ENST00000555610	ENST00000543680	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5UTR-3CDS	ENST00000556393	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5UTR-5UTR	ENST00000556393	ENST00000555794	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
5UTR-intron	ENST00000556393	ENST00000543680	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
In-frame	ENST00000261699	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
In-frame	ENST00000267436	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
In-frame	ENST00000421284	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
In-frame	ENST00000555423	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-
In-frame	ENST00000555610	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261699	L2HGDH	chr14	50778729	-	ENST00000216373	SOS2	chr14	50641270	-	4403	158	209	3187	992
ENST00000267436	L2HGDH	chr14	50778729	-	ENST00000216373	SOS2	chr14	50641270	-	4783	538	589	3567	992
ENST00000421284	L2HGDH	chr14	50778729	-	ENST00000216373	SOS2	chr14	50641270	-	4464	219	270	3248	992
ENST00000555423	L2HGDH	chr14	50778729	-	ENST00000216373	SOS2	chr14	50641270	-	4461	216	267	3245	992
ENST00000555610	L2HGDH	chr14	50778729	-	ENST00000216373	SOS2	chr14	50641270	-	4389	144	195	3173	992

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261699	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-	4.21E-05	0.9999578
ENST00000267436	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-	6.49E-05	0.99993503
ENST00000421284	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-	4.35E-05	0.9999565
ENST00000555423	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-	4.36E-05	0.99995637
ENST00000555610	ENST00000216373	L2HGDH	chr14	50778729	-	SOS2	chr14	50641270	-	4.15E-05	0.9999585

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Fusion Genomic Features for L2HGDH-SOS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for L2HGDH-SOS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:50778729/chr14:50641270)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
L2HGDH Q9H9P8	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

1180_1183

323

1333.0

Compositional bias

Note=Poly-Pro

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

1203_1208

323

1333.0

Compositional bias

Note=Poly-Pro

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

755_758

323

1333.0

Compositional bias

Note=Poly-Pro

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

442_546

323

1333.0

Domain

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

595_739

323

1333.0

Domain

N-terminal Ras-GEF

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

778_1017

323

1333.0

Domain

Ras-GEF

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SOS2

chr14:50778729

chr14:50641270

ENST00000216373

198_388

323

1333.0

Domain

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Fusion Gene Sequence for L2HGDH-SOS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43792_43792_1_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000261699_SOS2_chr14_50641270_ENST00000216373_length(transcript)=4403nt_BP=158nt
GGGGAGCGTGCGTAGGGGATGGTGCCAGCGCTGCGTTATTTGGTTGGTGCCTGCGGACGGGCCCGCGGGCTTTTCGCCGGTGGCTCCCCT
GGGGCGTGCGGGTTCGCGTCTGGGAGGCCAAGACCGCTGTGTGGAGGTAGCCGCAGCGCCAGCACCAGTCCATTGCTGATGGTTTTAAAG
AGGCAGTTCGTTATGTCCTTCCACGTCTTATGCTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTTACTAAAGCAATTGAAAGCAT
GTAGTGAAGAACAAGAAGACAGAGAATGTTTGAACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAGCATGGACCGAATTTACAAGC
AGTATTCACCTAGACGTCGACCTGGAGATCCTGTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACACCTGGCTATCAAAAAAATGA
ATGAAATTCAGAAAAATATCGATGGATGGGAAGGCAAAGATATTGGACAGTGTTGTAATGAATTCATTATGGAGGGACCATTGACAAGAA
TCGGTGCCAAACATGAACGGCATATTTTTCTGTTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGGCCAGACTCGGCTTCCAGGTT
ACAGTAGTGCAGAATACAGGTTAAAAGAAAAATTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGATACTTGTGAGCACAAGCATG
CATTTGAATTAGTATCCAAAGATGAGAACAGCATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAACTGGATGGCAGCCCTTATTT
CTCTTCATTATCGTAGTACTCTAGATCGAATGTTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACCACTGAGATTACCAAGTCCTG
AAGTATATCGTTTTGTAGTAAAAGACTCTGAGGAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAGTGGCATCCCCATTATTAAAG
GAGGAACTGTAGTGAAATTAATTGAAAGGTTAACATATCATATGTATGCAGATCCCAATTTTGTTCGTACTTTTCTTACCACATATCGTT
CATTTTGTAAACCACAGGAATTGCTGAGCTTACTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTACTGACGCAGACAAATTGGCAA
TAGAGAAAGGCGAGCAGCCAATCAGTGCAGACCTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACAACTTAGGATCTTAAATGTAT
TTCGGCATTGGGTTGAACATCATTTTTATGACTTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATCCTTCATTTCAAGTGTAAGAG
GGAAAGCTATGAAAAAATGGGTAGAGTCAATTGCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAACGGAGTAAGCCATAATATTA
CCTTTGAAAGTCCACCTCCACCAATTGAATGGCATATCAGCAAACCAGGACAGTTTGAAACATTTGATCTCATGACACTTCATCCAATAG
AAATTGCACGTCAGCTGACACTTTTGGAGTCTGATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGGGAGTGTGTGGACCAAAGAAG
ATAAAGAAATAAATTCTCCAAATTTATTAAAAATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGAAAAATGCATTGTGGAAGCAG
AAAATTTTGAAGAACGGGTGGCAGTACTAAGTAGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAATAATTTCAATGGCGTATTGG
AGATAGTCAGTGCAGTAAATTCAGTGTCAGTATACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAGGAAAAGGAAAATTTTGGACG
AAGCTGTGGAATTAAGTCAAGATCACTTTAAAAAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTGTGTGCCTTTTTTTGGAATAT
ATTTAACAAATATTCTGAAGACCGAAGAAGGGAATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAATCAATTTCAGTAAGAGGAGGA
AAGTAGCTGAAATTACTGGAGAAATTCAGCAGTATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGATATGAGGAGATTCTTTGAAA
ACCTTAACCCCATGGGAAGTGCATCTGAAAAAGAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAATTGAACCTCGAAACTGCAAAC
AGCCACCTCGATTTCCTAGGAAATCAACTTTTTCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCGACATGGCTCTACCTCAGGTA
CTTTACGAGGTCACCCAACACCATTAGAAAGAGAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAACTGAGCTGGAATCAACAGTGT
CAGCACCAACCTCTCCAAATACACCATCTACTCCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTTAGATGTGGATCTCAACAGCT
CCTGTGGCAGCAATAGCATCTTTGCTCCAGTGCTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTG
AAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATG
ATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGC
ATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTC
CATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCA
CTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCC
CTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACA
GACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTT
TTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAG
AATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAA
AGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTT
TTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTT
TTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTA
ATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTA
TTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCA
GACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATT
TAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAA
ATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATAT
ATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCC
ATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATT

>43792_43792_1_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000261699_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=992AA_BP=
MLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGW
EGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDEN
SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIER
LTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFY
DFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLE
SDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVS
VYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQ
QYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLE
REPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLP
PRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLG
HLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAET

--------------------------------------------------------------
>43792_43792_2_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000267436_SOS2_chr14_50641270_ENST00000216373_length(transcript)=4783nt_BP=538nt
AGTTTCTCCCACGGCCCCATGTCCGCATGGCGGTGAAGGTCGAAGACGCGCGACCCAAAGGGCCAGGTTTTCAGTCAGCCCAGCGTTGGC
GACGGGCGAGGGCAGAACACAACCACCACCCTAGTCCCGCCCGGCTCGGGGCCTAGCTTCTCTACTCACAGCGTCGGAGGGAGGGAGGGA
GGGAGCGAGCCAGCGTCCCCGCGTCTGCGGCACCCTGGCCGGCCCTTCGCCCTCCGACGCGCGCGCCTATTGGCCACCGCAGCCTCTCCC
ACATGGGGCGAAGGCGCGCCACTTCATTGGCCCCCGCGTGAGGGGCGGGGCTAAAGAGCGCGGGTCCTCGGCCGTGGAGGGTCAAGTGGC
TTCTTCTGAGCGCTGAGGGAGGGGAGCGTGCGTAGGGGATGGTGCCAGCGCTGCGTTATTTGGTTGGTGCCTGCGGACGGGCCCGCGGGC
TTTTCGCCGGTGGCTCCCCTGGGGCGTGCGGGTTCGCGTCTGGGAGGCCAAGACCGCTGTGTGGAGGTAGCCGCAGCGCCAGCACCAGTC
CATTGCTGATGGTTTTAAAGAGGCAGTTCGTTATGTCCTTCCACGTCTTATGCTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTT
ACTAAAGCAATTGAAAGCATGTAGTGAAGAACAAGAAGACAGAGAATGTTTGAACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAG
CATGGACCGAATTTACAAGCAGTATTCACCTAGACGTCGACCTGGAGATCCTGTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACA
CCTGGCTATCAAAAAAATGAATGAAATTCAGAAAAATATCGATGGATGGGAAGGCAAAGATATTGGACAGTGTTGTAATGAATTCATTAT
GGAGGGACCATTGACAAGAATCGGTGCCAAACATGAACGGCATATTTTTCTGTTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGG
CCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAATACAGGTTAAAAGAAAAATTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGA
TACTTGTGAGCACAAGCATGCATTTGAATTAGTATCCAAAGATGAGAACAGCATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAA
CTGGATGGCAGCCCTTATTTCTCTTCATTATCGTAGTACTCTAGATCGAATGTTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACC
ACTGAGATTACCAAGTCCTGAAGTATATCGTTTTGTAGTAAAAGACTCTGAGGAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAG
TGGCATCCCCATTATTAAAGGAGGAACTGTAGTGAAATTAATTGAAAGGTTAACATATCATATGTATGCAGATCCCAATTTTGTTCGTAC
TTTTCTTACCACATATCGTTCATTTTGTAAACCACAGGAATTGCTGAGCTTACTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTAC
TGACGCAGACAAATTGGCAATAGAGAAAGGCGAGCAGCCAATCAGTGCAGACCTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACA
ACTTAGGATCTTAAATGTATTTCGGCATTGGGTTGAACATCATTTTTATGACTTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATC
CTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAAAAATGGGTAGAGTCAATTGCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAA
CGGAGTAAGCCATAATATTACCTTTGAAAGTCCACCTCCACCAATTGAATGGCATATCAGCAAACCAGGACAGTTTGAAACATTTGATCT
CATGACACTTCATCCAATAGAAATTGCACGTCAGCTGACACTTTTGGAGTCTGATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGG
GAGTGTGTGGACCAAAGAAGATAAAGAAATAAATTCTCCAAATTTATTAAAAATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGA
AAAATGCATTGTGGAAGCAGAAAATTTTGAAGAACGGGTGGCAGTACTAAGTAGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAA
TAATTTCAATGGCGTATTGGAGATAGTCAGTGCAGTAAATTCAGTGTCAGTATACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAG
GAAAAGGAAAATTTTGGACGAAGCTGTGGAATTAAGTCAAGATCACTTTAAAAAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTG
TGTGCCTTTTTTTGGAATATATTTAACAAATATTCTGAAGACCGAAGAAGGGAATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAAT
CAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATTACTGGAGAAATTCAGCAGTATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGA
TATGAGGAGATTCTTTGAAAACCTTAACCCCATGGGAAGTGCATCTGAAAAAGAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAAT
TGAACCTCGAAACTGCAAACAGCCACCTCGATTTCCTAGGAAATCAACTTTTTCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCG
ACATGGCTCTACCTCAGGTACTTTACGAGGTCACCCAACACCATTAGAAAGAGAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAAC
TGAGCTGGAATCAACAGTGTCAGCACCAACCTCTCCAAATACACCATCTACTCCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTT
AGATGTGGATCTCAACAGCTCCTGTGGCAGCAATAGCATCTTTGCTCCAGTGCTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGG
TAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGG
AAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGG
TGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCC
AGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTAC
GTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCT
TGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCT
TTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAAT
GGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTAC
TGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTT
GGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGC
ACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGG
GTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACC
AACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAAT
GGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAG
ATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAG
TTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACT
AATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAA
CTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGT
GAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGC
CAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTATCAGAGTTCTTAACAAGATTAATAAATCACCCCAGTCT

>43792_43792_2_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000267436_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=992AA_BP=
MLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGW
EGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDEN
SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIER
LTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFY
DFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLE
SDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVS
VYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQ
QYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLE
REPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLP
PRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLG
HLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAET

--------------------------------------------------------------
>43792_43792_3_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000421284_SOS2_chr14_50641270_ENST00000216373_length(transcript)=4464nt_BP=219nt
GCTAAAGAGCGCGGGTCCTCGGCCGTGGAGGGTCAAGTGGCTTCTTCTGAGCGCTGAGGGAGGGGAGCGTGCGTAGGGGATGGTGCCAGC
GCTGCGTTATTTGGTTGGTGCCTGCGGACGGGCCCGCGGGCTTTTCGCCGGTGGCTCCCCTGGGGCGTGCGGGTTCGCGTCTGGGAGGCC
AAGACCGCTGTGTGGAGGTAGCCGCAGCGCCAGCACCAGTCCATTGCTGATGGTTTTAAAGAGGCAGTTCGTTATGTCCTTCCACGTCTT
ATGCTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTTACTAAAGCAATTGAAAGCATGTAGTGAAGAACAAGAAGACAGAGAATGT
TTGAACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAGCATGGACCGAATTTACAAGCAGTATTCACCTAGACGTCGACCTGGAGAT
CCTGTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACACCTGGCTATCAAAAAAATGAATGAAATTCAGAAAAATATCGATGGATGG
GAAGGCAAAGATATTGGACAGTGTTGTAATGAATTCATTATGGAGGGACCATTGACAAGAATCGGTGCCAAACATGAACGGCATATTTTT
CTGTTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGGCCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAATACAGGTTAAAAGAA
AAATTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGATACTTGTGAGCACAAGCATGCATTTGAATTAGTATCCAAAGATGAGAAC
AGCATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAACTGGATGGCAGCCCTTATTTCTCTTCATTATCGTAGTACTCTAGATCGA
ATGTTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACCACTGAGATTACCAAGTCCTGAAGTATATCGTTTTGTAGTAAAAGACTCT
GAGGAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAGTGGCATCCCCATTATTAAAGGAGGAACTGTAGTGAAATTAATTGAAAGG
TTAACATATCATATGTATGCAGATCCCAATTTTGTTCGTACTTTTCTTACCACATATCGTTCATTTTGTAAACCACAGGAATTGCTGAGC
TTACTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTACTGACGCAGACAAATTGGCAATAGAGAAAGGCGAGCAGCCAATCAGTGCA
GACCTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACAACTTAGGATCTTAAATGTATTTCGGCATTGGGTTGAACATCATTTTTAT
GACTTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATCCTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAAAAATGGGTAGAGTCA
ATTGCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAACGGAGTAAGCCATAATATTACCTTTGAAAGTCCACCTCCACCAATTGAA
TGGCATATCAGCAAACCAGGACAGTTTGAAACATTTGATCTCATGACACTTCATCCAATAGAAATTGCACGTCAGCTGACACTTTTGGAG
TCTGATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGGGAGTGTGTGGACCAAAGAAGATAAAGAAATAAATTCTCCAAATTTATTA
AAAATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGAAAAATGCATTGTGGAAGCAGAAAATTTTGAAGAACGGGTGGCAGTACTA
AGTAGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAATAATTTCAATGGCGTATTGGAGATAGTCAGTGCAGTAAATTCAGTGTCA
GTATACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAGGAAAAGGAAAATTTTGGACGAAGCTGTGGAATTAAGTCAAGATCACTTT
AAAAAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTGTGTGCCTTTTTTTGGAATATATTTAACAAATATTCTGAAGACCGAAGAA
GGGAATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAATCAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATTACTGGAGAAATTCAG
CAGTATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGATATGAGGAGATTCTTTGAAAACCTTAACCCCATGGGAAGTGCATCTGAA
AAAGAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAATTGAACCTCGAAACTGCAAACAGCCACCTCGATTTCCTAGGAAATCAACT
TTTTCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCGACATGGCTCTACCTCAGGTACTTTACGAGGTCACCCAACACCATTAGAA
AGAGAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAACTGAGCTGGAATCAACAGTGTCAGCACCAACCTCTCCAAATACACCATCT
ACTCCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTTAGATGTGGATCTCAACAGCTCCTGTGGCAGCAATAGCATCTTTGCTCCA
GTGCTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCT
CCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCT
CCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGAT
CCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGG
CATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTA
CCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCT
CATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACT
CCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTAT
TTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCT
TCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCAC
TGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAG
ATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTT
TACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCT
GCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACAT
AACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGC
CTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAAT
TTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTG
CCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAG
CAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGA
GTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTT

>43792_43792_3_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000421284_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=992AA_BP=
MLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGW
EGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDEN
SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIER
LTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFY
DFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLE
SDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVS
VYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQ
QYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLE
REPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLP
PRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLG
HLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAET

--------------------------------------------------------------
>43792_43792_4_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000555423_SOS2_chr14_50641270_ENST00000216373_length(transcript)=4461nt_BP=216nt
AAAGAGCGCGGGTCCTCGGCCGTGGAGGGTCAAGTGGCTTCTTCTGAGCGCTGAGGGAGGGGAGCGTGCGTAGGGGATGGTGCCAGCGCT
GCGTTATTTGGTTGGTGCCTGCGGACGGGCCCGCGGGCTTTTCGCCGGTGGCTCCCCTGGGGCGTGCGGGTTCGCGTCTGGGAGGCCAAG
ACCGCTGTGTGGAGGTAGCCGCAGCGCCAGCACCAGTCCATTGCTGATGGTTTTAAAGAGGCAGTTCGTTATGTCCTTCCACGTCTTATG
CTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTTACTAAAGCAATTGAAAGCATGTAGTGAAGAACAAGAAGACAGAGAATGTTTG
AACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAGCATGGACCGAATTTACAAGCAGTATTCACCTAGACGTCGACCTGGAGATCCT
GTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACACCTGGCTATCAAAAAAATGAATGAAATTCAGAAAAATATCGATGGATGGGAA
GGCAAAGATATTGGACAGTGTTGTAATGAATTCATTATGGAGGGACCATTGACAAGAATCGGTGCCAAACATGAACGGCATATTTTTCTG
TTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGGCCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAATACAGGTTAAAAGAAAAA
TTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGATACTTGTGAGCACAAGCATGCATTTGAATTAGTATCCAAAGATGAGAACAGC
ATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAACTGGATGGCAGCCCTTATTTCTCTTCATTATCGTAGTACTCTAGATCGAATG
TTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACCACTGAGATTACCAAGTCCTGAAGTATATCGTTTTGTAGTAAAAGACTCTGAG
GAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAGTGGCATCCCCATTATTAAAGGAGGAACTGTAGTGAAATTAATTGAAAGGTTA
ACATATCATATGTATGCAGATCCCAATTTTGTTCGTACTTTTCTTACCACATATCGTTCATTTTGTAAACCACAGGAATTGCTGAGCTTA
CTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTACTGACGCAGACAAATTGGCAATAGAGAAAGGCGAGCAGCCAATCAGTGCAGAC
CTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACAACTTAGGATCTTAAATGTATTTCGGCATTGGGTTGAACATCATTTTTATGAC
TTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATCCTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAAAAATGGGTAGAGTCAATT
GCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAACGGAGTAAGCCATAATATTACCTTTGAAAGTCCACCTCCACCAATTGAATGG
CATATCAGCAAACCAGGACAGTTTGAAACATTTGATCTCATGACACTTCATCCAATAGAAATTGCACGTCAGCTGACACTTTTGGAGTCT
GATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGGGAGTGTGTGGACCAAAGAAGATAAAGAAATAAATTCTCCAAATTTATTAAAA
ATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGAAAAATGCATTGTGGAAGCAGAAAATTTTGAAGAACGGGTGGCAGTACTAAGT
AGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAATAATTTCAATGGCGTATTGGAGATAGTCAGTGCAGTAAATTCAGTGTCAGTA
TACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAGGAAAAGGAAAATTTTGGACGAAGCTGTGGAATTAAGTCAAGATCACTTTAAA
AAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTGTGTGCCTTTTTTTGGAATATATTTAACAAATATTCTGAAGACCGAAGAAGGG
AATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAATCAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATTACTGGAGAAATTCAGCAG
TATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGATATGAGGAGATTCTTTGAAAACCTTAACCCCATGGGAAGTGCATCTGAAAAA
GAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAATTGAACCTCGAAACTGCAAACAGCCACCTCGATTTCCTAGGAAATCAACTTTT
TCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCGACATGGCTCTACCTCAGGTACTTTACGAGGTCACCCAACACCATTAGAAAGA
GAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAACTGAGCTGGAATCAACAGTGTCAGCACCAACCTCTCCAAATACACCATCTACT
CCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTTAGATGTGGATCTCAACAGCTCCTGTGGCAGCAATAGCATCTTTGCTCCAGTG
CTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATTCCTCCTCCTCTTCCTCCT
CGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATTCCACCGAGACAGCCTCCT
CCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCGCCACCACCAAGAGATCCT
CTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAGCCACCTCCACTGGGGCAT
CTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACACCCTCTCCAAGGGTACCG
CGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGGCAGAATTCAAGCCCTCAT
CTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTAGAAAATGCAGAAACTCCC
CAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAAAAAAAGACATAGTATTTT
AGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAAAAATACAAAAGTCCTTCA
CCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAGAATTTATATTTGCACTGT
AAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTCAAATTTGAGTAATAGATG
CCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGACCATCTTCTAGTTTTTAC
TTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAAATGCCGGTATTTGCTGCT
GAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGTAAACAAAGACTACATAAC
CCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTTTAGCTAATGAATTGCCTA
TTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTAATAACCTATATAAATTTA
AGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAGGAACCAACTGCCTTGCCT
TCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGGTAATATTTAAACCAGCAA
ATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTCGTTCAAAGTGATAGAGTG
TTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGCCTTTTACTGTGCTTTGTA

>43792_43792_4_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000555423_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=992AA_BP=
MLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGW
EGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDEN
SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIER
LTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFY
DFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLE
SDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVS
VYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQ
QYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLE
REPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLP
PRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLG
HLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAET

--------------------------------------------------------------
>43792_43792_5_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000555610_SOS2_chr14_50641270_ENST00000216373_length(transcript)=4389nt_BP=144nt
GGGGATGGTGCCAGCGCTGCGTTATTTGGTTGGTGCCTGCGGACGGGCCCGCGGGCTTTTCGCCGGTGGCTCCCCTGGGGCGTGCGGGTT
CGCGTCTGGGAGGCCAAGACCGCTGTGTGGAGGTAGCCGCAGCGCCAGCACCAGTCCATTGCTGATGGTTTTAAAGAGGCAGTTCGTTAT
GTCCTTCCACGTCTTATGCTGGTGCCAGTGTATCACTGTTGGCACTACTTTGAGTTACTAAAGCAATTGAAAGCATGTAGTGAAGAACAA
GAAGACAGAGAATGTTTGAACCAAGCTATTACTGCTCTCATGAATCTCCAAGGTAGCATGGACCGAATTTACAAGCAGTATTCACCTAGA
CGTCGACCTGGAGATCCTGTTTGCCCTTTTTATAGTCACCAATTAAGAAGCAAACACCTGGCTATCAAAAAAATGAATGAAATTCAGAAA
AATATCGATGGATGGGAAGGCAAAGATATTGGACAGTGTTGTAATGAATTCATTATGGAGGGACCATTGACAAGAATCGGTGCCAAACAT
GAACGGCATATTTTTCTGTTTGATGGCTTAATGATCAGTTGTAAACCTAATCATGGCCAGACTCGGCTTCCAGGTTACAGTAGTGCAGAA
TACAGGTTAAAAGAAAAATTTGTCATGAGGAAAATACAAATTTGTGATAAAGAAGATACTTGTGAGCACAAGCATGCATTTGAATTAGTA
TCCAAAGATGAGAACAGCATAATATTTGCTGCTAAGTCTGCTGAAGAAAAAAACAACTGGATGGCAGCCCTTATTTCTCTTCATTATCGT
AGTACTCTAGATCGAATGTTAGATTCAGTATTATTGAAAGAAGAAAATGAGCAACCACTGAGATTACCAAGTCCTGAAGTATATCGTTTT
GTAGTAAAAGACTCTGAGGAAAACATTGTTTTTGAAGACAACTTGCAAAGTAGAAGTGGCATCCCCATTATTAAAGGAGGAACTGTAGTG
AAATTAATTGAAAGGTTAACATATCATATGTATGCAGATCCCAATTTTGTTCGTACTTTTCTTACCACATATCGTTCATTTTGTAAACCA
CAGGAATTGCTGAGCTTACTGATTGAACGGTTTGAAATTCCAGAGCCAGAACCTACTGACGCAGACAAATTGGCAATAGAGAAAGGCGAG
CAGCCAATCAGTGCAGACCTTAAAAGATTTCGCAAGGAATATGTCCAACCAGTACAACTTAGGATCTTAAATGTATTTCGGCATTGGGTT
GAACATCATTTTTATGACTTTGAAAGAGACTTGGAATTGCTTGAAAGACTAGAATCCTTCATTTCAAGTGTAAGAGGGAAAGCTATGAAA
AAATGGGTAGAGTCAATTGCTAAGATCATCAGGAGGAAGAAGCAAGCTCAGGCAAACGGAGTAAGCCATAATATTACCTTTGAAAGTCCA
CCTCCACCAATTGAATGGCATATCAGCAAACCAGGACAGTTTGAAACATTTGATCTCATGACACTTCATCCAATAGAAATTGCACGTCAG
CTGACACTTTTGGAGTCTGATCTTTACAGGAAAGTTCAACCGTCTGAACTTGTAGGGAGTGTGTGGACCAAAGAAGATAAAGAAATAAAT
TCTCCAAATTTATTAAAAATGATTCGCCATACCACAAATCTCACCCTCTGGTTTGAAAAATGCATTGTGGAAGCAGAAAATTTTGAAGAA
CGGGTGGCAGTACTAAGTAGAATTATAGAAATTCTGCAAGTTTTTCAAGATTTGAATAATTTCAATGGCGTATTGGAGATAGTCAGTGCA
GTAAATTCAGTGTCAGTATACAGACTAGACCATACCTTTGAGGCACTGCAGGAAAGGAAAAGGAAAATTTTGGACGAAGCTGTGGAATTA
AGTCAAGATCACTTTAAAAAATACCTAGTAAAACTTAAGTCAATCAATCCACCTTGTGTGCCTTTTTTTGGAATATATTTAACAAATATT
CTGAAGACCGAAGAAGGGAATAATGATTTTTTAAAAAAGAAAGGGAAAGATTTAATCAATTTCAGTAAGAGGAGGAAAGTAGCTGAAATT
ACTGGAGAAATTCAGCAGTATCAGAATCAGCCTTACTGTTTACGGATAGAACCAGATATGAGGAGATTCTTTGAAAACCTTAACCCCATG
GGAAGTGCATCTGAAAAAGAGTTTACAGATTATTTGTTCAACAAGTCACTAGAAATTGAACCTCGAAACTGCAAACAGCCACCTCGATTT
CCTAGGAAATCAACTTTTTCCTTAAAATCTCCTGGAATAAGGCCTAACACAGGCCGACATGGCTCTACCTCAGGTACTTTACGAGGTCAC
CCAACACCATTAGAAAGAGAACCATGTAAAATAAGCTTTAGTCGGATTGCTGAAACTGAGCTGGAATCAACAGTGTCAGCACCAACCTCT
CCAAATACACCATCTACTCCACCAGTATCTGCTTCTTCAGACCTTAGTGTATTTTTAGATGTGGATCTCAACAGCTCCTGTGGCAGCAAT
AGCATCTTTGCTCCAGTGCTTTTGCCACATTCAAAGTCTTTCTTTAGTTCATGTGGTAGTTTACATAAACTAAGTGAAGAGCCCCTGATT
CCTCCTCCTCTTCCTCCTCGAAAAAAGTTTGATCATGATGCTTCAAATTCCAAGGGAAATATGAAATCTGATGATGATCCTCCTGCTATT
CCACCGAGACAGCCTCCTCCTCCAAAGGTAAAACCCAGAGTTCCTGTTCCTACTGGTGCATTTGATGGGCCTCTGCATAGTCCACCTCCG
CCACCACCAAGAGATCCTCTTCCTGATACCCCTCCACCAGTTCCCCTTCGGCCTCCAGAACACTTTATAAACTGTCCATTTAATCTTCAG
CCACCTCCACTGGGGCATCTTCACAGAGATTCAGACTGGCTCAGAGACATTAGTACGTGTCCAAATTCGCCAAGCACTCCTCCTAGCACA
CCCTCTCCAAGGGTACCGCGTCGATGCTATGTGCTCAGTTCTAGTCAGAATAATCTTGCTCATCCTCCAGCTCCCCCTGTTCCACCAAGG
CAGAATTCAAGCCCTCATCTGCCAAAACTGCCACCAAAGACTTACAAACGGGAGCTTTCGCACCCCCCATTGTACAGACTGCCTTTGCTA
GAAAATGCAGAAACTCCCCAATGACCTTAGCCATATGTAGTCATTGACACTGGAATGGTATTTGTAAAGTTTTTTTTTTAATTTATTCAA
AAAAAGACATAGTATTTTAGTACTTTTTACAAATAATGCTCTTACAAAAATGCTACTGATCAAATAAGCTTTTAAGAATTGGAAAAATAA
AAATACAAAAGTCCTTCACCATTATCCTCAGGTGATCAGTAGCATTGCCTTGTCTTGGATCCTCAGTGCTGCCAAAAGGCCAGTATAAAG
AATTTATATTTGCACTGTAAACTCTGCAAAAATATGGTTTAAAGTGACATGATTGCACTGAAAAGGGATAGTGCTTTTGTGAAATTTTTC
AAATTTGAGTAATAGATGCCTTTTTAAGGCAGTGAATTTACACAAATATGGGAGGGGTATATGGTGTTACTGATTTTTAAACCTCTTTGA
CCATCTTCTAGTTTTTACTTCTAGTTTTTACATCTAGGAGAATTGTGAATAACACCAACTGTTCTTAAACTCTTTAATGCCATGTCTTAA
ATGCCGGTATTTGCTGCTGAAGACAAAAATGAAAAGTAGGATGAAAATAATAGAATGGCACTGTAAGTGTTTATTATTTTGTCAAAATGT
AAACAAAGACTACATAACCCAATGATGGAGGGAAAAAGGGCATGTATCTCATTCAGATGTGCCTTTTGTTTTTGCAGACTATGACGTCTT
TAGCTAATGAATTGCCTATTGTTATGGAAAACAGTTAATATGCCATGTATGTACAGTTTTGTTTATATTGTATATTTAAAGATACTGCTA
ATAACCTATATAAATTTAAGTGACTTGAGGCCTATAATACAATCTGCTACTTTACTAATTCATAAATTCAAAAAAAATTCTATGGCATAG
GAACCAACTGCCTTGCCTTCAAGACCTAGTAACTTTCTCTATAAATCTCGTGTTAACTGAAATTTTTTTTAAATATATTTTTTAGATTGG
TAATATTTAAACCAGCAAATACTTAAAGCTTTATTAAACATTTTAATCAGATAAGTGAGTAAAGCTTTTATTTGCCATTTGGATGCCTTC
GTTCAAAGTGATAGAGTGTTTTGCTGATAGTGCTGTAGCAGCAGTTGTAAAGTAGCCAAAAGCCACGTTGTTTATTTACTGGTTTGTGGC

>43792_43792_5_L2HGDH-SOS2_L2HGDH_chr14_50778729_ENST00000555610_SOS2_chr14_50641270_ENST00000216373_length(amino acids)=992AA_BP=
MLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGW
EGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSKDEN
SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIER
LTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFY
DFERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLE
SDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVS
VYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQ
QYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLE
REPCKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLSEEPLIPPPLP
PRKKFDHDASNSKGNMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPLHSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLG
HLHRDSDWLRDISTCPNSPSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLLENAET

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for L2HGDH-SOS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for L2HGDH-SOS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for L2HGDH-SOS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source