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	Fusion Gene Summary
	Fusion Gene ORF analysis
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	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:L3MBTL4-TRDMT1 (FusionGDB2 ID:43810)

Fusion Gene Summary for L3MBTL4-TRDMT1

Fusion gene summary

Fusion gene information	Fusion gene name: L3MBTL4-TRDMT1
	Fusion gene ID: 43810
		Hgene	Tgene
	Gene symbol	L3MBTL4	TRDMT1
	Gene ID	91133	1787
	Gene name	L3MBTL histone methyl-lysine binding protein 4	tRNA aspartic acid methyltransferase 1
	Synonyms	HsT1031	DMNT2\|DNMT2\|MHSAIIP\|PUMET\|RNMT1
	Cytomap	18p11.31	10p13
	Type of gene	protein-coding	protein-coding
	Description	lethal(3)malignant brain tumor-like protein 4H-l(3)mbt-like protein 4L3MBTL4, histone methyl-lysine binding protein	tRNA (cytosine(38)-C(5))-methyltransferaseDNA (cytosine-5)-methyltransferase-like protein 2DNA MTase homolog HsaIIPDNA cytosine-5 methyltransferase 2DNA methyltransferase-2tRNA (cytosine-5-)-methyltransferase
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000284898, ENST00000317931, ENST00000400104, ENST00000400105, ENST00000535782, ENST00000578677,	ENST00000457442, ENST00000452380, ENST00000488990, ENST00000351358, ENST00000358282, ENST00000377766, ENST00000377799, ENST00000412821,
Fusion gene scores	* DoF score	8 X 8 X 4=256	3 X 3 X 2=18
	# samples	8	3
	** MAII score	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: L3MBTL4 [Title/Abstract] AND TRDMT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	L3MBTL4(6237963)-TRDMT1(17216659), # samples:2
Anticipated loss of major functional domain due to fusion event.	L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. L3MBTL4-TRDMT1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TRDMT1	GO:0030488	tRNA methylation	16424344

Fusion gene breakpoints across L3MBTL4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRDMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-ZF-AA4T-01A	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-

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Fusion Gene ORF analysis for L3MBTL4-TRDMT1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000284898	ENST00000457442	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-5UTR	ENST00000317931	ENST00000457442	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-5UTR	ENST00000400104	ENST00000457442	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-5UTR	ENST00000400105	ENST00000457442	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-5UTR	ENST00000535782	ENST00000457442	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000284898	ENST00000452380	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000284898	ENST00000488990	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000317931	ENST00000452380	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000317931	ENST00000488990	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000400104	ENST00000452380	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000400104	ENST00000488990	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000400105	ENST00000452380	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000400105	ENST00000488990	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000535782	ENST00000452380	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
5CDS-intron	ENST00000535782	ENST00000488990	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000284898	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000284898	ENST00000358282	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000284898	ENST00000377766	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000284898	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000284898	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000317931	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000317931	ENST00000358282	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000317931	ENST00000377766	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000317931	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000317931	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400104	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400104	ENST00000358282	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400104	ENST00000377766	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400104	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400104	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400105	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400105	ENST00000358282	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400105	ENST00000377766	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400105	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000400105	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000535782	ENST00000358282	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
Frame-shift	ENST00000535782	ENST00000377766	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
In-frame	ENST00000535782	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
In-frame	ENST00000535782	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
In-frame	ENST00000535782	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-3CDS	ENST00000578677	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-3CDS	ENST00000578677	ENST00000358282	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-3CDS	ENST00000578677	ENST00000377766	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-3CDS	ENST00000578677	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-3CDS	ENST00000578677	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-5UTR	ENST00000578677	ENST00000457442	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-intron	ENST00000578677	ENST00000452380	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-
intron-intron	ENST00000578677	ENST00000488990	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000535782	L3MBTL4	chr18	6237963	-	ENST00000377799	TRDMT1	chr10	17216659	-	3689	274	0	1385	461
ENST00000535782	L3MBTL4	chr18	6237963	-	ENST00000412821	TRDMT1	chr10	17216659	-	1477	274	0	1313	437
ENST00000535782	L3MBTL4	chr18	6237963	-	ENST00000351358	TRDMT1	chr10	17216659	-	1411	274	0	1247	415

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000535782	ENST00000377799	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-	0.000152685	0.9998473
ENST00000535782	ENST00000412821	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-	0.000352308	0.99964774
ENST00000535782	ENST00000351358	L3MBTL4	chr18	6237963	-	TRDMT1	chr10	17216659	-	0.000227811	0.99977225

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Fusion Genomic Features for L3MBTL4-TRDMT1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for L3MBTL4-TRDMT1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:6237963/chr10:17216659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000284898

160_260

261

624.0

Repeat

Note=MBT 2

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000284898

52_152

261

624.0

Repeat

Note=MBT 1

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400104

160_260

261

535.0

Repeat

Note=MBT 2

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400104

52_152

261

535.0

Repeat

Note=MBT 1

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400105

160_260

261

624.0

Repeat

Note=MBT 2

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400105

52_152

261

624.0

Repeat

Note=MBT 1

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000351358

57_58

346.0

Region

S-adenosyl-L-methionine binding

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000358282

57_58

143.0

Region

S-adenosyl-L-methionine binding

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000377799

57_58

392.0

Region

S-adenosyl-L-methionine binding

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000412821

57_58

368.0

Region

S-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000284898

543_607

261

624.0

Domain

SAM

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400104

543_607

261

535.0

Domain

SAM

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400105

543_607

261

624.0

Domain

SAM

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000284898

269_364

261

624.0

Repeat

Note=MBT 3

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400104

269_364

261

535.0

Repeat

Note=MBT 3

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400105

269_364

261

624.0

Repeat

Note=MBT 3

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000284898

370_414

261

624.0

Zinc finger

CCHHC-type

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400104

370_414

261

535.0

Zinc finger

CCHHC-type

Hgene

L3MBTL4

chr18:6237963

chr10:17216659

ENST00000400105

370_414

261

624.0

Zinc finger

CCHHC-type

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000351358

4_391

346.0

Domain

SAM-dependent MTase C5-type

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000358282

4_391

143.0

Domain

SAM-dependent MTase C5-type

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000377799

4_391

392.0

Domain

SAM-dependent MTase C5-type

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000412821

4_391

368.0

Domain

SAM-dependent MTase C5-type

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000351358

13_15

346.0

Region

S-adenosyl-L-methionine binding

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000358282

13_15

143.0

Region

S-adenosyl-L-methionine binding

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000377799

13_15

392.0

Region

S-adenosyl-L-methionine binding

Tgene

TRDMT1

chr18:6237963

chr10:17216659

ENST00000412821

13_15

368.0

Region

S-adenosyl-L-methionine binding

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Fusion Gene Sequence for L3MBTL4-TRDMT1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>43810_43810_1_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000351358_length(transcript)=1411nt_BP=274nt
TTGCAAAATGCTCCAAAGAAATTATTCAGAAACAGAAGTCCTAATGGGCCAATGTCTAAAGAATTTCAGGTTGGAATGAAGCTGGAGGCC
GTGGACAGGAAGAACCCTTCCTTGGTGTGTGTGGCGACCATAGCAGATATTGTTGAAGATCGCTTACTAGTGCATTTTGACAACTGGGAT
GATAGTTACGATTACTGGTGCGATGTTAATAGCCCTTATGTCCAGCCAGTTGGTTGGTGTCAGGAGAATGGAAGAACTCTGATAGCACCC
CAAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAATGAAGTATACAAGTATAATTTTCCTCACACA
CAGTTACTTGCCAAGACGATTGAAGGCATTACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGAGACCTCTTGATACAAACAATAGAAAATTGTGGCTTTCAGTACCAAGAGTTTCTATTATCTCCAACCTCTCTTGGCATT
CCAAATTCAAGGCTACGATATTTTCTTATTGCAAAGCTTCAGTCAGAGCCATTACCCTTTCAAGCCCCTGGTCAGGTACTGATGGAGTTC
CCCAAAATTGAATCTGTACATCCACAAAAATATGCAATGGATGTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTT
GATGGCAGCATACAGTGTTCTGGAAAAGATGCCATTCTTTTTAAGCTTGAAACTGCAGAAGAAATTCACAGGAAAAATCAACAAGATAGT
GATCTCTCTGTGAAAATGCTAAAAGATTTTCTTGAAGATGACACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATAT
GCTCTTCTGTTAGACATTGTTCAGCCCACTTGTAGAAGGTCCGTGTGCTTTACCAAAGGATATGGAAGCTACATAGAAGGGACAGGGTCT
GTGTTACAGACTGCAGAGGATGTGCAGGTTGAGAATATCTACAAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTA
ATACTTAAACTGCGATATTTCACTCCTAAAGAAATAGCAAATCTCCTTGGATTTCCTCCAGAGTTCGGATTTCCTGAGAAGATAACAGTG
AAACAGCGTTATCGCCTACTTGGAAATAGTCTCAACGTGCATGTAGTAGCTAAACTAATCAAAATCTTATATGAATAATTTTGAAATAAC
TCTGAAAGATGGTCATATGATATTCCTTCATTTTCAGAGAGTAATTCTGAAATTCTGTTTTGAACTAATTCTGGTGAAATTTAACTAAAT

>43810_43810_1_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000351358_length(amino acids)=415AA_BP=91
LQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAP
QESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRDLLIQTIENCGFQYQEFLLSPTSLGI
PNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDS
DLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLL

--------------------------------------------------------------
>43810_43810_2_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000377799_length(transcript)=3689nt_BP=274nt
TTGCAAAATGCTCCAAAGAAATTATTCAGAAACAGAAGTCCTAATGGGCCAATGTCTAAAGAATTTCAGGTTGGAATGAAGCTGGAGGCC
GTGGACAGGAAGAACCCTTCCTTGGTGTGTGTGGCGACCATAGCAGATATTGTTGAAGATCGCTTACTAGTGCATTTTGACAACTGGGAT
GATAGTTACGATTACTGGTGCGATGTTAATAGCCCTTATGTCCAGCCAGTTGGTTGGTGTCAGGAGAATGGAAGAACTCTGATAGCACCC
CAAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAATGAAGTATACAAGTATAATTTTCCTCACACA
CAGTTACTTGCCAAGACGATTGAAGGCATTACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGGATTGGCCGGCAGGGTGATATGACTGATTCAAGGACGAATAGCTTCTTACATATTCTAGATATTCTCCCAAGATTACAA
AAATTACCAAAGTATATTCTTTTGGAAAATGTTAAAGGTTTTGAAGTATCTTCTACAAGAGACCTCTTGATACAAACAATAGAAAATTGT
GGCTTTCAGTACCAAGAGTTTCTATTATCTCCAACCTCTCTTGGCATTCCAAATTCAAGGCTACGATATTTTCTTATTGCAAAGCTTCAG
TCAGAGCCATTACCCTTTCAAGCCCCTGGTCAGGTACTGATGGAGTTCCCCAAAATTGAATCTGTACATCCACAAAAATATGCAATGGAT
GTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTTGATGGCAGCATACAGTGTTCTGGAAAAGATGCCATTCTTTTT
AAGCTTGAAACTGCAGAAGAAATTCACAGGAAAAATCAACAAGATAGTGATCTCTCTGTGAAAATGCTAAAAGATTTTCTTGAAGATGAC
ACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATATGCTCTTCTGTTAGACATTGTTCAGCCCACTTGTAGAAGGTCC
GTGTGCTTTACCAAAGGATATGGAAGCTACATAGAAGGGACAGGGTCTGTGTTACAGACTGCAGAGGATGTGCAGGTTGAGAATATCTAC
AAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTAATACTTAAACTGCGATATTTCACTCCTAAAGAAATAGCAAAT
CTCCTTGGATTTCCTCCAGAGTTCGGATTTCCTGAGAAGATAACAGTGAAACAGCGTTATCGCCTACTTGGAAATAGTCTCAACGTGCAT
GTAGTAGCTAAACTAATCAAAATCTTATATGAATAATTTTGAAATAACTCTGAAAGATGGTCATATGATATTCCTTCATTTTCAGAGAGT
AATTCTGAAATTCTGTTTTGAACTAATTCTGGTGAAATTTAACTAAATTATTTTAATCTGTCCTTATTAAGAAATTTGGATTTTATTAAA
AAAATCCATGTGTTTCATCAAATTTATATTACTGTATTTTATAAAATACGAACTATTGTTATGCTTTATGGAGAGTATATTTTCATATGA
AACTGATAAATATATATGTGGAATATTCTTTTTAAAAACAATTTTATAAACAAATCAAGGAGCACTAGAGCTTTAGTGTCTACATGAGTA
TCTTGTGAAGTGTCATAACAGGCATAACATATTTTTATGTTAATTAAAGAAGTTTTTTATTTCTAATTTTAAAATAATGATTCTAATTCT
AGCCCATTGAATGTTTTACTTAATTTCCAATCCTGTAAATATTTCTTTATTTCATCTAAACAAATGCATATGATATGTAAACCAAATTAT
CATCATTCAGTTTATACAGCAGACTGAAGAATATGTCAGGAAAAATAATCCTAAATGTTTGATTACCTCTCCATGAAGCGGCCACAGAAA
CTGTTGGTGCACATTATCTACATTTTCCTCAGCCTCTATCTGAAGGACAAAACTCATTTTTCCTTCTTCATTTTGTATGTACTTTCCTTT
AGTTGACTATTATCAAAGCTTGTTTTTGTCTTCTCAGCTTCTGAGTTGAATTTGCCTTTGCACGCTGAGGAATGTAGCATGACGTTAAGA
TTTCAGGGAGGAAGCTGCCCTCTGATCCCATGTCATATGACAGTACTCCCCTCCCCCCAGTTGTTCTTTATTGTAGCAACATACACTCTC
AATGAACTTTTATGACTTTTAACTTTCTCTGTCTCTCTTCCTCAGCAGACCTCTTGGAATTAGGGTTTCTAATCAAACTAAGTCTTGCAT
CATAAATTCTATGGTTTGTGATAAAAGCAAGTGACAAAGAGAAGAGAGATGAAAAGAAACAAGTCCAGAAATCATATTACAAGATTTTAA
TTCAAATTTTTCTTCTTAAAAATCAGCTATTTAGAGGTGGATAAATTGGAAGTTTGTGCATTGCTTGTGGGAACGTAAAATGGTTCAGCT
GCTGTTGGAAAACGCTATGGAGGTTCGTCACAAAATTCAACATAGAATTACCCTATGATTCAGCGATTCCACCTCTGGCTATAGATCCAA
AAGAATTGAAAGCAGGGACTTGAACAGATATTTGTACACCAGCGTTTATAACACCATTATTTACAGTAGCCAAAAGGTAGAAGCAGCCCA
AGTGTCATCCCATTCACCCATGAATGGATGCAGGAATTGTGTTCCGTGCATGCAGTGGAATAGTACCAGCCTTCCGCAGGAAGGAAATTC
TGACATATGCGGTGACATGGATGAACCTTGAGTACATTATGCGAAGTGAAATAAGCCACCCTGTGGGGATGGAGAATGGGTAGTTAGTGC
ATAATGGATACAAAGTTTCTGATTGGGGTGATGAGAAAGTTCTGGAGGTGGATGGGGAGGATGGTTGCACAACAGTGTGAGTGTACTTAA
TGCCACTGCAACTGTATATTTAAAAATAGTTAAAATGATAAATTTTACATTATGTATATTTTACTGCAATTGAAAAAATCATACTCTATT
ACCAATTTTTCAGAACTCATAGATAAATATGAATGTAGGGAAGCTGTAAGCCAGCCCATATACAGAAACTATCACTATCTACATTTTTCA
TATGTGTTCAGACAGAGCCTATTACAAGTCTCATAAATTTCAGTAAACAATCACAAATTATTTTGGCACACTTTCATGTAGGTTCTGTTC
ACTGCTGAAATATTCTAAATAAAATGGTTTAGAGTTTTACTGTAACTATGAATAATTATGCTATAATTATAGTATCCCACATTCGGTTGA
GCAACATTATACAAAATAAGTGTCGAGTTACTGTGCACCAACTATAAATACTTGAAAGGTCTGTAGAGACATTTGCTTACAAACTGGTAG
ACAGAATGTAGCTTAGTGGAATTCTTAAATTATGGGAATGTATTCACAGGAAGACGGTGATTCTTGCCCTTAATTCATAATTGAAAATAT
GCAGTAACAAGCATAAAACTCACATCTTAATGAAGATGTATCTACCAGTGTCATTCAATTAGCAGATGTATATGTATGCATAATTAATTT

>43810_43810_2_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000377799_length(amino acids)=461AA_BP=91
LQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAP
QESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQ
KLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMD
VENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRS
VCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVH

--------------------------------------------------------------
>43810_43810_3_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000412821_length(transcript)=1477nt_BP=274nt
TTGCAAAATGCTCCAAAGAAATTATTCAGAAACAGAAGTCCTAATGGGCCAATGTCTAAAGAATTTCAGGTTGGAATGAAGCTGGAGGCC
GTGGACAGGAAGAACCCTTCCTTGGTGTGTGTGGCGACCATAGCAGATATTGTTGAAGATCGCTTACTAGTGCATTTTGACAACTGGGAT
GATAGTTACGATTACTGGTGCGATGTTAATAGCCCTTATGTCCAGCCAGTTGGTTGGTGTCAGGAGAATGGAAGAACTCTGATAGCACCC
CAAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAATGAAGTATACAAGTATAATTTTCCTCACACA
CAGTTACTTGCCAAGACGATTGAAGGCATTACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGATTACAAAAATTACCAAAGTATATTCTTTTGGAAAATGTTAAAGGTTTTGAAGTATCTTCTACAAGAGACCTCTTGATA
CAAACAATAGAAAATTGTGGCTTTCAGTACCAAGAGTTTCTATTATCTCCAACCTCTCTTGGCATTCCAAATTCAAGGCTACGATATTTT
CTTATTGCAAAGCTTCAGTCAGAGCCATTACCCTTTCAAGCCCCTGGTCAGGTACTGATGGAGTTCCCCAAAATTGAATCTGTACATCCA
CAAAAATATGCAATGGATGTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTTGATGGCAGCATACAGTGTTCTGGA
AAAGATGCCATTCTTTTTAAGCTTGAAACTGCAGAAGAAATTCACAGGAAAAATCAACAAGATAGTGATCTCTCTGTGAAAATGCTAAAA
GATTTTCTTGAAGATGACACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATATGCTCTTCTGTTAGACATTGTTCAG
CCCACTTGTAGAAGGTCCGTGTGCTTTACCAAAGGATATGGAAGCTACATAGAAGGGACAGGGTCTGTGTTACAGACTGCAGAGGATGTG
CAGGTTGAGAATATCTACAAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTAATACTTAAACTGCGATATTTCACT
CCTAAAGAAATAGCAAATCTCCTTGGATTTCCTCCAGAGTTCGGATTTCCTGAGAAGATAACAGTGAAACAGCGTTATCGCCTACTTGGA
AATAGTCTCAACGTGCATGTAGTAGCTAAACTAATCAAAATCTTATATGAATAATTTTGAAATAACTCTGAAAGATGGTCATATGATATT
CCTTCATTTTCAGAGAGTAATTCTGAAATTCTGTTTTGAACTAATTCTGGTGAAATTTAACTAAATTATTTTAATCTGTCCTTATTAAGA

>43810_43810_3_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000412821_length(amino acids)=437AA_BP=91
LQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAP
QESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRLQKLPKYILLENVKGFEVSSTRDLLI
QTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSG
KDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for L3MBTL4-TRDMT1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for L3MBTL4-TRDMT1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for L3MBTL4-TRDMT1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source